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World’s First Cloned Cat Dies – Texas A&M University Today

Posted: March 7, 2020 at 3:47 pm

Copy Cat was born Dec. 22, 2001.

Texas A&M College of Veterinary Medicine & Biological Sciences

CC, the worlds first cloned cat, has passed away at the age of 18 after being diagnosed with kidney failure.

CC, short for Copy Cat, passed away on March 3 in College Station, the same place where her life began as a result of groundbreaking cloning work done by Texas A&M University College of Veterinary Medicine & Biomedical Sciences (CVM) researchers.

CC was born Dec. 22, 2001, and was adopted by Dr. Duane Kraemer, a senior professor in the colleges Reproduction Sciences Laboratory, and his wife, Shirley, six months after her birth.

We in the CVM are saddened by the passing of CC. As the first cloned cat, CC advanced science by helping all in the scientific community understand that cloning can be effective in producing a healthy animal, said Dr. Eleanor M. Green, the Carl B. King dean of veterinary medicine at Texas A&M.

While she lived a long, normal, and happy life, CC was extraordinary in what she represented to the Kraemers, the CVM, and science as a whole, Green said. The entire CVM community mourns her loss, as all at Texas A&M cared deeply about her as a member of the Aggie family, and especially for the Kraemers, for whom CC was a beloved pet for 18 years.

CCs story began with Dr. Mark Westhusin, a CVM professor and the principal investigator of the Missyplicity Project, a $3.7 million effort to clone a mixed-breed dog named Missy that was owned by John Sperling, founder of the University of Phoenix.

When the news of the project spread, people around the country became interested in saving pets tissues that could possibly be used for cloning in the future. This demand resulted in the establishment of Genetic Savings and Clone (GSC), Inc., led by Sperlings colleagues Lou Hawthorne and Dr. Charles Long.

While GSC became a bank for these tissues, Westhusin and his team at Texas A&M began to explore the cloning of other pet species, specifically cats.

CC was produced using nuclear transfer of DNA from cells that were derived from a female domestic shorthair named Rainbow.

Copy Cat was adopted at six months old by Dr. Duane Kraemer, a senior professor in Reproduction Sciences Laboratory, and his wife, Shirley, six months after her birth.

Texas A&M College of Veterinary Medicine & Biological Sciences

Once it was clear the nuclear transfer was successful, Kraemer and other scientists transferred the embryos into a surrogate mother, who gave birth to a healthy kitten about two months later.

Though the cats were identical on a genetic level, developmental factors led them to have slightly different coat patterns and color distributions.

CCs passing makes me reflect on my own life as much as hers, Westhusin said. Cloning now is becoming so common, but it was incredible when it was beginning. Our work with CC was an important seed to plant to keep the science and the ideas and imagination moving forward.

CC also became one of the first cloned cats to become a mother. When CC was five years old, she gave birth to three kittens that lived with her for the rest of her life in a custom, two-story cat house in the Kraemers backyard.

CC was the biggest story out of A&M ever and still is, as far as international reach is concerned, Kraemer said. Every paper and magazine had pictures of her in it. She was one of the biggest accomplishments of my career.

While CC represented a great advancement in genetic research, to the Kraemers, she was also a beloved pet. She will be missed by them especially, but also by those at the CVM, Texas A&M and beyond who have followed her story since birth.

CC was a great cat and a real joy, Kraemer said. She was part of the family and very special to us. We will miss her every day.

Throughout her lifetime, CC regularly made news for her birth, pregnancy and each birthday. She proved to the world that cloned animals can live the same full, healthy lives as non-cloned animals, including being able to produce healthy offspring.

Before CC, no pet had ever been successfully cloned with 100 percent genetic identity.

The research that led to CCs birth kickstarted a global pet cloning industry led by ViaGen Pets, which today clones cats for $35,000 and dogs for $50,000.

Though CC was the first successfully cloned pet, Texas A&M has gone on to clone more species than any other institution in the world, including horses, pigs, goats, cattle and deer.

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Hey, Paul Davies Your ID is Showing – Discovery Institute

Posted: March 6, 2020 at 2:58 pm

Editors note:Dr. Shedingeris a Professor of Religion at Luther College in Decorah, Iowa. He is the author of a recent book critiquing Darwinian triumphalism,The Mystery of Evolutionary Mechanisms.

No better advertisements for intelligent design exist than works written by establishment scientists that unintentionally make design arguments. I can think of few better examples than well-known cosmologist Paul Daviess recently published book The Demon in the Machine: How Hidden Webs of Information Are Solving the Mystery of Life (2019).

With a nod toward James Clerk Maxwells entropy-defying demon, Davies argues that the gulf between physics and biology is completely unbridgeable without some fundamentally new concept. Since living organisms consistently resist the ravages of entropy that all forms of inanimate matter are subject to, there must be some non-physical principle allowing living matter to consistently defy the Second Law of Thermodynamics. And for Davies there is; the demon in the machine turns out to be information.

Throughout the book, Davies marvels at the stunning complexity of life, especially at the cellular and molecular levels. He wonders at the existence of molecular machines like motors, pumps, tubes, shears, and rotors paraphernalia familiar to human engineers and their ability to manipulate information in clear and super-efficient ways, in Daviess words conjuring order out of chaos. In fact, he calls the cell a vast web of information management, observing that while molecules are physical structures, information is an abstract concept deriving from the world of human communication.

Yet despite all these analogies between the nanotechnology of life and the world of human engineering, Davies deftly ignores the obvious conclusion the nanotechnology of life must have been designed, just like human-engineered machinery. Though he tries valiantly to ignore this obvious conclusion, Davies cannot completely run and hide, for he explicitly says, It is hard not to be struck by how ingenious all this machinery is, and how astonishing that it remains intact and unchanged over billions of years. (Emphasis in the original.) Indeed! Anything so ingenious must, almost by definition, be the product of intelligence if we are not to drain the word ingenious of its meaning.

But trying to ignore the implications of his own work, Davies soldiers on with more unintentional ID statements:

Lifes ability to construct an internal representation of the world and itself to act as an agent, manipulate its environment and harness energy reflects its foundation in the rules of logic. It is also the logic of life that permits biology to explore a boundless universe of novelty.

Logic, of course, is a product of mental activity. So is Davies implying an active intelligence working at the cellular and molecular level? It appears so even if he would never admit it. Yet he does practically admit it when he throws up his hands and declares, Indeed, lifes complexity is so daunting that it is tempting to give up trying to understand it in physical terms.

If the molecular machinery of the cell has overwhelmed Davies with its sublime complexity, he is equally astounded by the field of epigenetics: In the magic puzzle box of life, epigenetic inheritance is one of the more puzzling bits of magic. He discusses the research on directed mutation by John Cairns in the 1980s, more recent work on epigenetics by Eva Jablonka, and the early work on transposition by Barbara McClintock and its flourishing in James Shapiros Natural Genetic Engineering and concludes: its tempting to imagine that biologists are glimpsing an entire shadow information-processing system at work at the epigenetic level. Tempting indeed! And lest we forget, information processing derives from and is a property of intelligence.

Finally, Davies turns to the origin of life question which he brands as almost a miracle. He agrees that chemistry alone cannot explain the origin of life because one also needs to account for the origin of information. For Davies:

Semantic information is a higher-level concept that is simply meaningless at the level of molecules. Chemistry alone, however complex, can never produce the genetic code or contextual instructions. Asking chemistry to explain coded information is like expecting computer hardware to write its own software.

The origin of coded information is, according to Davies, the toughest problem in evolutionary biology. But, of course, it is only a tough problem for those who have excluded intelligence from the equation a priori. From an ID perspective, the origin of information is no mystery at all. It is always the creation of intelligent minds, a point made consistently by Stephen Meyer.

To explain all this, Davies can do no better than to speculate that somehow new laws and principles emerge from information processing systems of sufficiently great complexity. But he entirely ignores the question of the origin of the information processing system itself, which he has already pronounced as beyond the ability of chemistry alone to explain.

It is likely that Davies would never want to align himself with the ID community. He might believe that the professional cost is just too great. But if I didnt know any better, I would swear that The Demon in the Machine had rolled right off the presses of Discovery Institute. If abstract information is truly at the root of life, then intelligence has to be factored into the equation. Davies has made a compelling case for the former, so by extension and much to his chagrin he seems to be making a compelling case for the latter.

Photo: Paul Davies, by Cmichel67 / CC BY-SA.

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Hey, Paul Davies Your ID is Showing - Discovery Institute

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TARE May Be the Future of Genome Editing, Improving on CRISPR Gene Drive – Clinical OMICs News

Posted: March 6, 2020 at 2:58 pm

CRISPR technology has led to innumerable advances in our understanding of the human genome and genetically inherited diseases, however it is not without imperfections. A newer technology, TARE (Toxin-Antidote Recessive Embryo), is being tested out in animal studies, which have thus far been very promising. TARE genomic modification technology improves on CRISPR in two aspects: genetic expression of the modified gene and the ability to pass on the mutation to future generations.

TARE was developed for modifying the epigenetics of non-human species, but as it is a genomic editing technology, can be used to test and modify any genome through the same mechanisms, including human.

CRISPR uses gene drives from genetic engineering to create a desired mutation in a few individuals. To spread this mutation, these individuals mates with a larger population, thus modifying the epigenetics of that species by passing on their DNA. In humans, it could remove and replace an allele that causes a disease.

In theory, such a mechanism could be used to prevent malarial mosquitoes from transmitting disease, or possibly wipe out an invasive species by disabling its ability to reproduce.

Though scientists have had success proving the concept in the lab, they have found that wild populations invariably adapt and develop resistance to the scheme. And when gene drives work, they are and all or nothing, meaning either the gene is modified or not.

A new Cornell study titled, A toxin-antidote CRISPR gene drive system for regional population modification, published Feb. 27 in the journalNature Communications, describes a new type of gene drive with the potential to delay this resistance.

In a classic gene drive, called a homing drive, an offspring inherits one set of genes, or genome, from the mother and another from the father. If an offspring inherits a gene with a drive from one parent and not the other, the drive copies itself into the genome from the parent without the drive.

Those are two things that this new drive that we developed here addresses to some extent, said Philipp Messer, an assistant professor of computational biology, and the papers senior author. Jackson Champer, a postdoctoral researcher in Messers lab, is the first author.

Now that individual has that drive in both of its genomes and it will pass it on to every offspring, Messer said.

The drives are engineered with CRISPR-Cas9 gene-editing technology, so when the drive are copied into a new genome, the CRISPR machinery will cut into the chromosome without the drive, and paste in the new code. However, occasionally cells will repair the incision and, in doing so, randomly delete DNA letters. When this happens, the CRISPR gene drive can no longer find a genetic sequence it recognizes in order to make the incision, which creates resistance to the gene insertion and stops the gene drive from spreading.

Natural genetic variationanother source of changes in DNA sequencescan also create resistance to editing technology, since CRISPR gene drives must recognize short genetic sequences in order to make the genomic incision.

We were among the first labs to show that this is a tremendous problem, Messer said.

The paper describes a new gene drive, called TARE (Toxin-Antidote Recessive Embryo), which works by targeting a gene that is essential for an organism to function. Because the organism can survive with only one intact copy of this essential gene, instead of cutting and pasting DNA as homing drives do, the TARE drive simply cuts the other parents gene, disabling it.

Meanwhile, the engineered TARE drive gene has a DNA sequence that has been recoded; the gene works but it wont be recognized or cut in future generations. This way, if an offspring inherits two disabled genes, those individuals wont survive, thereby removing those copies from the population. Meanwhile, as viable individuals mate, more and more surviving offspring will carry TARE drive genes.

This technology allows for a more smooth genetic modification, and one that can last for several generations without worries of the gene being lost after insertion.

Because TARE drives do not cut and paste a drive into a target gene, instead they destroy one of the target gene copies in the offspring, the drive requires a higher frequency of engineered individuals in the population to spread. For this reason, TARE drives are less likely to transfer from one distinct population to another.

A CRISPR gene drive that carries a red fluorescent protein as payload is spread through a population of fruit flies in laboratory experiments. [Jackson Champer/Cornell University]In lab experiments, when fruit flies with TARE gene drives were released in cages of wild-type fruit flies, all the flies in the cage had the TARE drive in just six generations.

The researchers pointed out that resistance can indeed evolve with a TARE drive in the wild, especially in very large populations, but they believe it will take longer and evolve at a much lower rate, Messer said. The implications of using this technology to study human disease remain to be seen.

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TARE May Be the Future of Genome Editing, Improving on CRISPR Gene Drive - Clinical OMICs News

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NIH-funded i3 Center formed to advance cancer immunotherapy – Harvard Gazette

Posted: March 6, 2020 at 2:56 pm

Steven Hodi Jr., the i3 Centers other PI, and director of Melanoma Center and the Center for Immuno-Oncology at Dana-Farber, and professor of medicine at Harvard Medical School (HMS), is leading the clinical cancer vaccine trial. He has been at the forefront of developing cancer immunotherapies using immune checkpoint inhibitors, a class of drugs able to re-activate tumor-destroying T cells that are muted in the tumor microenvironment. The funding for this center provides a unique opportunity to unite key investigators for translating fundamental advancements in immunology and biomedical engineering into highly synergistic approaches to improve the treatments for cancer patients, said Hod

Using both in vivo and ex vivo biomaterials-based approaches, the i3 Center aims to boost tumor-specific activities of cytotoxic T cells, by boosting different stages of the normal process by which T cells develop, and acquire anti-cancer activity. T cells normal development starts in the bone marrow where hematopoietic stem cells generate T cell progenitor cells. These migrate to the thymus to differentiate into nave T cells, which then travel further to lymph nodes. There, they encounter cancer-derived antigens presented to them by specialized antigen-presenting cells (APCs) that can activate T cells to recognize and eliminate cancer cells.

In relation to adoptive T cell therapies in which T cells are given to patients to fight their cancers, one team at the i3 Center will be led by Dana-Farber researchers Catherine J. Wu and Jerome Ritz, who along with Mooney, will develop and test biomaterials that can better mimic normal APCs in activating and directing the function of patient-derived T cells outside the human body, prior to their transplantation. Wu is chief of the Division of Stem Cell Transplantation and Cellular Therapies, and Ritz is executive director of the Connell and OReilly Families Cell Manipulation Core Facility at Dana-Farber.

We need to make efforts to enhance the ability of theimmune systemto recognizetumor cells. One directionmylaboratoryis taking makes use of innovative biomaterialsto help us to efficiently expandpolyclonaltumor-specificfunctionally-effectiveT cellsex vivoin a way that can be readily translated to theclinical setting. In our studies, we are currently focusing on melanoma and acute myeloid leukemia, said Wu, whose research interests include understanding the basis of effective human anti-tumor responses, including the identification and targeting of the tumor-specific antigens.

A second project explores the use of DNA origami, biocompatible nanostructures composed of DNA, to create cancer vaccines. DNA origami could provide significant advantages in presenting tumor-specific antigens and immune-enhancing adjuvants to APCs because the concentrations, ratios, and geometries of all components can be modulated with nano-scale precision to determine configurations that are more effective than other vaccination strategies. The project will be run by Wyss Institute Core Faculty member William Shih, Derin Keskin, lead immunologist at Dana-Farbers Translational Immunogenomics Lab, and Mooney.

In a third project, David Scadden, professor at Harvards Department of Stem Cell and Regenerative Biology, will collaborate with Mooney to build on their previous work. They will engineer biomaterials that recreate key features of the normal hematopoietic stem cell niche in the bone marrow. Such implantable biomaterials could help rapidly amplify T cell progenitor cells, and enhance T cell-mediated anti-cancer immunity. Scadden also is the Gerald and Darlene Jordan Professor of Medicine at Harvard University, and co-director of the Harvard Stem Cell Institute.

The i3 Centers investigators anticipate that it will stimulate additional cross-disciplinary concepts and research, due to the culture of continuous interactions, sharing of findings, data and samples between all investigators, as well strong biostatistical expertise provided by Donna Neuberg, a senior biostatistician broadly involved with exploring immune-modulating cancer interventions at the Dana-Farber.

This new i3 Center for cancer immunotherapy innovation really embodies how the Wyss Institute with its unparalleled capabilities in bioengineering and serving as a site for multidisciplinary collaboration, and can liaise with clinicians and researchers at our collaborating institutions to confront major medical problems and bring about transformative change, said Wyss Founding Director Donald Ingber. He is also theJudah Folkman Professor of Vascular Biologyat HMS and the Vascular Biology Program at Boston Childrens Hospital, and Professor of Bioengineering at SEAS.

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NIH-funded i3 Center formed to advance cancer immunotherapy - Harvard Gazette

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51% #1597: Gen X Women Can’t Sleep; Music Conveys The Science Of Climate Change – WAMC

Posted: March 6, 2020 at 2:53 pm

On this weeks 51%, why is there so much angst among Gen X women? A female Army recruit talks about her choice, and well hear from a woman who is part of a climate music project.

At age 43, author Ada Calhoun had achieved many of the outward marks of success and personal fulfillment, however, she still felt lousy. In her new book, Why We Cant Sleep: Womens New Midlife Crisis, Calhoun consulted with generational research/ data experts and interviewed hundreds of Generation X women (defined by Calhoun as those born between 1965-1980) in a quest for answers. What she found was that many pervasive struggles expressed by women around her age were unique to Gen X women. By the way, there is a reference during the interview to HRT, which stands for Hormone Replacement Therapy. Calhoun spoke with 51%s Elizabeth Hill about her new book and Gen X women.

The Army has been trying some new methods to recruit more soldiers. A new marketing campaign, called Whats Your Warrior launched in November. Its short on crawling in the mud and long on high tech. Dan Boyce reports for the American Homefront Project.

This story was produced by the American Homefront Project, a public media collaboration that reports on American military life and veterans. Funding comes from the Corporation for Public Broadcasting.

Next, 51%s Elizabeth LoGiudice brings us a story about a woman who has embraced music as a tool for communicating the science of climate change.

Thats our show for this week. Thanks to Tina Renick for production assistance. Our executive producer is Dr. Alan Chartock. Our theme music is Glow in the Dark by Kevin Bartlett. This show is a national production of Northeast Public Radio. If youd like to hear this show again, sign up for our podcast, or visit the 51% archives on our web site at wamc.org. And follow us on Twitter @51PercentRadio

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51% #1597: Gen X Women Can't Sleep; Music Conveys The Science Of Climate Change - WAMC

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Non Surgical Aesthetics Are in High Demand, So Thread Lifts Are a New Way to Achieve Instant Skin Tightening – Yahoo Finance

Posted: March 6, 2020 at 2:53 pm

Painless non surgical skin tightening procedures are now available and very popular for people who don't want to go through surgery in order to look better. Call LifeGaines in Boca Raton for more information about "Thread Lifts."

Boca Raton, Florida--(Newsfile Corp. - March 5, 2020) - Thread Lifts are a simple, painless procedure used for skin tightening on the face, neck, or anywhere else on the body. As popular and effective as Botox is, it simply doesn't have the ability to lift the skin. In the past, there hasn't been a great way to produce lifting results without surgery.

Call LifeGaines to inquire about this new method of skin tightening in the South Florida area. Call 561-295-9007.

To view an enhanced version of this image, please visit:https://orders.newsfilecorp.com/files/6848/53186_lifegaines_orig.jpg

Non-surgical aesthetics are in high demand and ThreadLifts, new to the United States, have the ability to produce skin that is instantly lifted and tightened.

This procedure uses no cuts or incisions, only injections. Threads are needles that are pre-loaded with PDO thread. The whole needle is inserted in the tissue at the sub-dermal level, along the surface of the skin and then the needle is pulled out. Threads can be used nearly anywhere on the body, but they are especially effective on the neck and jawline.

What is PDO?

Polydioxanone (PDO) sutures have been used for surgical procedures for many decades. It is one of the safest materials to implant in the body. PDO is completely dissolvable and your skin fully absorbs it within 4 to 6 months, leaving no scar tissue behind. This is especially effective when it's used together with chemical peels, Botox, and fillers to effect a patient's entire facial structure, remove sunspots and other conditions.

It is a great way to rejuvenate and restore youthful contours to brows, cheeks, jowls and the neck area. They are also effective on the breasts, buttocks and upper arms, areas that are prone to sagging due to weight loss, aging, pregnancy and childbirth or poor muscle tone.

Thread Lifts are a great way to rejuvenate and restore youthful contours to brows, cheeks, jowls and the neck area. Results from threads generally last between 12 months to several years depending on the area that has been treated, how many threads are used and what kinds of threads are used in each needle.

Amy Steffey, is a Licensed Nurse Practitioner with LifeGaines Medical and Aesthetics, and with Thread Liftsprocedure, she helps Boca Raton residents regain their confidence with rejuvenating procedures and body contouring.

Amy Steffey works at LifeGaines, which is one of the most highly respected Age Management Medical teams in South Florida. Age Management Medicine pioneer Dr. Richard Gaines is the founder of LifeGaines, and he has years of experience specializing in Hormone Replacement Therapy, Sexual Wellness, Platelet-rich Plasma, Stem Cells, Aesthetics, and Advanced Age Management protocols.

LifeGaines is located at 3785 N Federal Hwy #150, Boca Raton, FL 33431.

Call 561-295-9007 Today to Schedule a Consultation with Amy Steffey at LifeGaines Medical & Aesthetics Center in Boca Raton.

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people-who-dont-want-to-do-surgery.jpg People who don't want to do surgery could consider a non-surgical way of tightening skin. Call LifeGaines to inquire about this new method of skin tightening in the South Florida area. Call 561-295-9007.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/53186

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Non Surgical Aesthetics Are in High Demand, So Thread Lifts Are a New Way to Achieve Instant Skin Tightening - Yahoo Finance

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I was forced to go through the menopause aged 19 after crippling endometriosis battle – The Scottish Sun

Posted: March 6, 2020 at 2:53 pm

AT just 19-years-old, the last thing Kia Morne expected was that she would have to go through the menopause while she was still a teenager.

The student nurse, now 21, had been plagued by crippling endometriosis - which caused agonising abdominal pain, nausea, bowel problems and low blood pressure.

And doctors decided that the only way to alleviate her agony was to give her a course of Zoladex - a man-made hormone that induces the menopause.

Kia was instantly catapulted into the full force of side effects - including hot sweats, mood changes and hair loss.

The teen, who has since found some relief from her endometriosis, is now sharing her story to raise awareness for the debilitating condition which affects one in ten women.

She is also trying to raise money to freeze her eggs - in the hopes she can still have children in the future.

Speaking of her condition, Kia said: "Suffering with endometriosis is a continual struggle.

"You feel embarrassed the condition is to do with your periods, then you have to be believed and then you have to be diagnosed.

"To top all this off, the condition and treatment means you may not be able to have children.

Suffering with endometriosis is a continual struggle

"It is odd to be thinking of children when it is something that I'd think about so far in the future.

"So then to be told I have to raise 5,000 for this is awful. Nothing about having endometriosis is win-win.

"It would be good if, somewhere along the way, this condition would be considered sensitively."

Endometriosis is where tissue such as that in the lining of the womb grows elsewhere in the body - often around the reproductive organs, bowel and bladder.

As well as extremely heavy periods,endometriosis can cause agonising pain and sometimes infertility.

Kia first feared she had the condition when she was 14 - even before her periods came at 15 - when she suffered with abdominal pain, nausea, bowel problems and low blood pressure.

Her health took a more serious turn when she began fainting a year later, due to heavy bleeding during her period.

Over time doctors diagnosed Kia with food poisoning, allergies and irritable bowel syndrome.

However, she finally got her diagnosis when she was 19 after switching to a female GP and undergoing an exploratory operation of her abdomen - called a laparoscopy.

"There are many misdiagnoses, so I felt a sigh of relief that my illness finally had a name," said Kia.

"But there is no cure."

In a trial and error treatment routine Kia was first put on the contraceptive pill but that did not work.

But after suffering from excruciating cramps for five years, doctors decided to give Kiaa course of Zoladex, a man-made hormone that induces the menopause.

It reduces the growth of endometriosis by stopping her periods altogether throughshutting down her ovaries to stop the production of oestrogen, which aggravates the condition.

It is a risky treatment, as Kia's ovaries could struggle to re-stimulate if she is in chemical menopause for too long.

She said: "Coming to terms with my reproductive organs and fertility being compromised has been overwhelming and devastating."

She felt the treatment's full force of side effects - hot sweats, dizziness, headaches, mood changes, hair loss, bone and joint pain, skin reactions, sleep issues, fatigue, nausea, memory issues, blurred vision, bloating and swelling.

And Kia still experiences these symptoms more often associated with middle-aged women.

Symptoms of endometriosis

Endometriosis is where cells like the ones in the lining of the womb (uterus) are found elsewhere in the body.

Each month, these cells react in the same way to those in the womb - building up and then breaking down and bleeding. Unlike the cells in the womb that leave the bodyas a period, this blood has no way to escape.

That can lead to infertility, fatigue, bowel and bladder problems, as well as really heavy, painful periods.

It affects one in ten women in the UK.

Symptoms include:

The cause of endometriosis is unknown and there is no definite cure.

According to Endometriosis UK, it takes over seven years on average for women to finally receive a diagnosis.

It's estimated that up to 50 per cent of infertile women has the condition.

Source:Endometriosis UK

Kia now has hormone replacement therapy to help alleviate some of the side effects.

Sadly, the worst side-effect of the early menopause and endometriosis for Kia is she has to think about her fertility and the fact she may not be able to have children.

In a bitter twist, freezing her eggs is only available to cancer patients on the NHS so she has to raise an astronomical sum herself.

In the UK, egg freezing costs on average between 3,500 and 4,500 for one cycle of treatment.

In addition to this price, there is an annual fee to keep eggs stored - from 200 to 360.

SELF-TAUGHTTeacher fainted in school from endo pains but had to diagnose herself on Google

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LACK OF KNOWLEDGEOver half of UK population doesn't know know what endometriosis is

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SHARE SUPPORTWhat is Endometriosis Awareness Month and how can I show my support?

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TRIAL PERIODEndo sufferer, 25, urges Scots to make switch to reusable menstrual products

Kia decided to have surgery and a hormone-releasing coil fitted, so she can freeze her eggs, giving her a better shot of having children in the future.

Her mum, Fay Morne, has set up a Go Fund Me page and is running the London Marathon in April and the Fylde Cost Tri-olgy triathlon series (in April, May and September), to help Kia raise money to freeze her eggs.

Kia added: "What would be better would be to make this treatment free for endometriosis sufferers on the NHS, but that would be too late for me."

You can donate to Kia's cause here.

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I was forced to go through the menopause aged 19 after crippling endometriosis battle - The Scottish Sun

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Embarrassing health complaints women shouldnt be ashamed of – Yahoo Lifestyle

Posted: March 6, 2020 at 2:53 pm

From leaking urine after childbirth to the joys of menopause, women are subject to many embarrassing health complaints.

Hot flushes may leave you red faced (literally), but experts insist these ailments happen to the best of us and are nothing to be ashamed of.

Failing to confide in a doctor could leave you suffering in silence for years, if not decades.

Read more: Menopausal delay surgery that costs at least 6,000 has no evidence

"Many conditions that cause embarrassment are often ignored but this just results in symptoms continuing and, in some cases, getting worse, Dr Sarah Brewer, medical director of Healthspan, told Yahoo UK.

Dont ignore any symptom that is bothersome or which worries you, even if you are embarrassed.

Seek medical advice so you can start the correct treatment, regain your self-confidence and get back to normal life.

With International Womens Day on Sunday, doctors told Yahoo UK its time women let go of the shame.

Many women unintentionally pass urine after giving birth, often when they laugh or cough.

According to Dr Daniel Atkinson clinical lead at Treated.com as many as a third of new mothers suffer.

Carrying a child and giving birth is hard on your body and postpartum urinary incontinence is nothing to be ashamed of, he told Yahoo UK.

Speak to other mothers about the issue if its getting you down.

Natural births cause the vaginal canal to stretch.

It stretches and causes damage to the collagen, elastin and pelvic floor; a widening happens and affects the vaginal walls, causing them to weaken, Dr Tania Adib, consultant gynaecologist at The Medical Chambers Kensington told Yahoo UK.

The damage is done post childbirth, but some women dont get symptoms for a long time after.

Pelvic floor exercises, both during pregnancy and after labour, can be key to keeping those muscles strong.

While it may be distressing, Dr Atkinson claims urinary incontinence tends to pass within six months of labour.

It may sound counter-intuitive, but drinking water could help, with dehydration irritating the bladder.

Dr Atkinson also recommends avoiding coffee and spicy foods, as well as wearing sanitary-style pads to mop up any leaks.

Some menopausal women find fans enough of a relief during a hot flush, while others opt for hormonal treatment. (Getty Images)

As if mood swings and insomnia were not enough to contend with, hot flushes are often a tell-tale sign a woman is going through the change.

Most women start the menopause at 51, leaving them unable to become pregnant naturally.

Falling oestrogen levels can make them hot and bothered, leading to sweat patches and a flushed face.

This feeling can last for several minutes and can be unpleasant for women, said Dr Atkinson.

It is, however, a very common part of the menopause and is nothing to be embarrassed about.

Read more: Vaginal dryness causes menopausal women to give up on a sex life

Some manage with light clothing, cool showers and fans, however, others turn to hormone replacement therapy (HRT) gels, patches or implants.

Although extremely effective at relieving menopausal symptoms, HRT has been linked to blood clots and breast cancer in some women.

For most, however, the benefits of HRT are generally believed to outweigh the risks.

Irritable bowel syndrome (IBS) is a generic term for conditions that affect the digestive system.

IBS has proven notoriously difficult to treat and is recognised as not just a problem of bowel function, but results from faulty communication between the gut and brain, said Dr Brewer.

Normally, the brain filters out all the sensations involved with digestion, such as the bowel contractions that propel solid wastes downwards, so these do not reach the level of conscious thought.

When you have IBS, however, these sensations are not filtered out as well as normal and the signals produced by over-sensitive stretch receptors in the gut lining get through to the brain where they are perceived as pain.

The poorly-understood disorder can trigger everything from bloating and diarrhoea to constipation and smelly wind.

Twice as many women are affected by IBS than men, so you are not alone, said Dr Atkinson.

A 2015 American Physiological Society study found the nerves in the brains of female rats received more signals that suppress the intestinal movement of food, offering one explanation of why digestion problems are more common in women.

Some have also suggested women may be more likely to seek help, leading to a diagnosis, while bashful men stick it out.

Read more: How to enjoy sex during the menopause

Unfortunately, IBS is likely to affect you throughout your life and there is not a cure for it, said Dr Atkinson.

When it comes to treating the syndrome, doctors often recommend patients get to know their triggers, eat slowly and find ways to relax.

Common triggers include wheat, gluten, dairy, yeast, excess sugar and artificial sweeteners.

The National Institute for Health and Care Excellence (NICE) recognises the benefits of probiotics, good bacteria, if taken for at least four weeks.

It also advocates a low-FODMAP fermentable oligosaccharides, disaccharides, monosaccharides and polyols diet.

Basically, these are a group of fermentable (gas-producing) sugars and fibres, said Dr Brewer.

Eating foods high in FODMAPs increases the volume of liquid and gas in the small intestine which can trigger IBS symptoms.

A low-FODMAP diet is made up of minimal fructose the sugar in fruit, lactose the sugar in dairy, and sweeteners.

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Embarrassing health complaints women shouldnt be ashamed of - Yahoo Lifestyle

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International Women’s Day 8 March: LKF conducts research on women’s health with women leading the way – marketscreener.com

Posted: March 6, 2020 at 2:53 pm

DGAP-News: ABF Pharmaceutical Services GmbH / Key word(s): MiscellaneousInternational Women's Day 8 March: LKF conducts research on women's health with women leading the way

06.03.2020 / 09:45 The issuer is solely responsible for the content of this announcement.

International Women's Day 8 March: LKF conducts research on women's health with women leading the way

Kiel and Hamburg, Germany, and Vienna, Austria, 06 March 2020 - LKF - Laboratorium fr Klinische Forschung GmbH, a subsidiary of GBA Group Pharma, is honouring International Women's Day on 8 March 2020 by highlighting the company's female success factors.

"Every day is Women's Day at LKF," says Brbel Wilke, co-founder and CEO of LKF, with 80 percent of its 150 employees being women. Many of the 120 female employees working in the three-storey laboratory are highly qualified specialists and scientists from the fields of chemistry, biology, molecular biology et al.

When the medical-technical assistant Brbel Wilke started analysing blood counts together with Prof. Dr. Wolfgang Junge in 1991, she benefited from the fact that, as the mother of a three-year-old son, she was able to work mostly at night. "Flexibility is not only essential for working mothers, it is also what our customers value most about us. It's in our DNA," says Wilke. For example, LKF not only offers 30 different family-friendly working time models, but also the highest degree of flexibility towards the customer. A recipe for success that has paid off. Since its founding in 1991, LKF has recorded continuous revenue growth of 10-15 percent per year.

Numerous studies in the field of women's healthFrom planning to execution, the broad range of services offered by LFK today covers all aspects of the laboratory part of clinical studies. One of the focal points is the area of Women's Health. "The improvement of women's health is a central research field of the pharmaceutical industry, which we have successfully supported for many years," says Brbel Wilke. In addition to contraception and hormone replacement therapy, this includes in-vitro fertilisation (unfulfilled desire to have children) and osteoporosis therapy.

"Due to the extensive hormone studies, we offer a very large list of specific coagulation parameters. The background here is the potential risk of thrombosis," said Wilke. In the field of menstrual blood quantification, LKF offers a comprehensive solution worldwide.

LFK also has many years of experience in endometriosis studies, a disease in which tissue similar to the lining of the uterus is grows outside the uterus. In Germany alone, for example, about 7-15 percent of all women of reproductive age are affected every month. In other countries, the disease rate is up to 20 percent.

Women in the lead"Thanks to their expertise, women play an extremely important role in the success of LKF as well as of other companies in our group," explains Dr. Elisabeth Lackner, CEO of the parent company GBA Group Pharma. "It is no surprise that three of our subsidiaries, Pharmacelsus, GBA Pharma Labs and LKF, are managed by female CEOs."

About LKFLKF - Laboratorium fr Klinische Forschung GmbH, based in Kiel, is part of GBA Group Pharma and supports Phase I - IV clinical trials. Within its global network of partner laboratories in North and Latin America, India, China and Australia, LKF offers worldwide laboratory services for clinical trials. All data is gathered in a central database in Kiel, from where it is sent to doctors worldwide.

LKF has established a strict quality management system based on the international guidelines GCP and ISO 17025. Sustainability also plays an important role. LKF has been EcoVadis certified since 2016.

About GBA Group PharmaGBA Group Pharma, as part of GBA, is a unique service provider for the international pharmaceutical and biotech industry with 6 sites in Austria and Germany. GBA Group Pharma offers preclinical (Pharmacelsus) and analytical laboratory services (GBA Pharma Labs), and with its central clinical laboratory (LKF) in combination with ABF, a full service provider for clinical trial products (IMP), comprehensive services and expertise for development and approved drugs.GBA Group Pharma employs around 500 people in Austria, Germany and the UK.GBA Group Pharma is part of the GBA Group (Hamburg, Germany).

For further information please contact:

GBA Group Pharma Natalie Eiffe-KuhnMobile: +43 676 897115513Email: Natalie.Eiffe@abf-pharma.com

Media and Investor RelationsMC Services AGJulia HofmannT +49 89 210 228 0Email: gba-abf@mc-services.eu

06.03.2020 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG.The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Archive at http://www.dgap.de

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International Women's Day 8 March: LKF conducts research on women's health with women leading the way - marketscreener.com

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CO2 Incubators Market Update: Uncover the Business Strategies of Leaders & Laggards of the Market – 3rd Watch News

Posted: March 6, 2020 at 12:46 am

CO2 Incubator is a device which is used to grow and maintain the tissue culture cell under a CO2 atmosphere. These incubators also maintain the natural environment with optimal humidity, temperature, and other conditions. Typical temperature settings range is from 4C to 50C, CO2 concentrations run from 0.3 to 19.9% and relative humidity of about 95 percent in these CO2 incubators and have a PH of 7.2 to 7.5. These incubators are most commonly used in biology labs to perform tissue culture or cell development and are used in any process where both bacterial, as well as eukaryotic cells, need to be cultured for a few hours or many weeks or where cells need to be expanded or maintained. These are one of the most widely used incubators in any cell culturing laboratory environment. The global carbon dioxide incubator market is expected to witness significant growth during the forecast period by increasing the number of applications of carbon dioxide incubators such as cancer research, embryonic cell research, stem cell research, neuroscience, tissue engineering and cultivation of mammalian cells.

A new business intelligence report released by Advance Market Analytics with title Global CO2 Incubators Market Insights, Forecast to 2025 has abilities to raise as the most significant market worldwide as it has remained playing a remarkable role in establishing progressive impacts on the universal economy. The Global CO2 Incubators Market Report offers energetic visions to conclude and study market size, market hopes, and competitive surroundings. The research is derived through primary and secondary statistics sources and it comprises both qualitative and quantitative detailing.

Some of the key players profiled in the study are Thermo Scientific, Eppendorf (Germany), Panasonic Healthcare Co (Japan), Binder, NuAire, LEEC (United Kingdom), ESCO, Memmert (India), Caron and Sheldon Manufacturing.

Free Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/3431-global-co2-incubators-market-2

Market Overview of Global CO2 IncubatorsIf you are involved in the Global CO2 Incubators industry or aim to be, then this study will provide you inclusive point of view. Its vital you keep your market knowledge up to date segmented by major players. If you have a different set of players/manufacturers according to geography or needs regional or country segmented reports we can provide customization according to your requirement.

This study mainly helps understand which market segments or Region or Country they should focus in coming years to channelize their efforts and investments to maximize growth and profitability. The report presents the market competitive landscape and a consistent in depth analysis of the major vendor/key players in the market.

Market Trend

Market Drivers

Opportunities

Restraints

Challenges

Key Target Audience

CO2 Incubators Manufacturers, CO2 Incubators Potential Investors, Traders, Distributors, Wholesalers, Retailers, Importers, and Exporters., Association and government bodies. and Others

For Early Buyers | Get Up to 20% Discount on This Premium Report: https://www.advancemarketanalytics.com/request-discount/3431-global-co2-incubators-market-2The Global CO2 Incubators Market segments and Market Data Break Down are illuminated below:by Type (Water Jacketed CO2 Incubators, Air-Jacketed CO2 Incubators, Direct Heat CO2 Incubators), Application (Industrial, Biotechnology, Agriculture, Others), Capacity Type (Below 100L, Above 100L & Below 200L, Above 200L)Furthermore, the years considered for the study are as follows:Historical year 2014-2018Base year 2019Forecast period** 2020 to 2025 [** unless otherwise stated]

**Moreover, it will also include the opportunities available in micro markets for stakeholders to invest, detailed analysis of competitive landscape and product services of key players.

Region Included are: North America, Europe, Asia Pacific, Oceania, South America, Middle East & Africa

Country Level Break-Up: United States, Canada, Mexico, Brazil, Argentina, Colombia, Chile, South Africa, Nigeria, Tunisia, Morocco, Germany, United Kingdom (UK), the Netherlands, Spain, Italy, Belgium, Austria, Turkey, Russia, France, Poland, Israel, United Arab Emirates, Qatar, Saudi Arabia, China, Japan, Taiwan, South Korea, Singapore, India, Australia and New Zealand etc.

Get More Information & Customization:https://www.advancemarketanalytics.com/enquiry-before-buy/3431-global-co2-incubators-market-2Important Features that are under offering & key highlights of the report: Market Data Segmentation with production, consumption, revenue (million USD), and Price Analysis Detailed overview of CO2 Incubators market Changing market dynamics of the industry In-depth market segmentation by Type, Application etc Historical, current and projected market size in terms of volume and value Recent industry trends and developments Competitive landscape of CO2 Incubators market Strategies of key players and product offerings Potential and niche segments/regions exhibiting promising growth A neutral perspective towards CO2 Incubators market performance Must-have information for market players to sustain and enhance their market footprint

Major Highlights of TOC:

Chapter One: Market Overview

1.1. Introduction

1.2. Scope/Objective of the Study

Chapter Two: Executive Summary

2.1. Introduction

Chapter Three: Market Dynamics

3.1. Introduction

3.2. Market Driverss

Chapter Four: Market Factor Analysis

4.1. Porters Five Forces

4.2. Supply/Value Chain

4.3. PESTEL analysis

4.4. Market Entropy

4.5. Patent & Trademark Analysis

Chapter Nine: Methodology and Data Source

9.1. Methodology/Research Approach

9.2. Data Source

9.3. Disclaimer

Key questions answered Who are the Leading key players and what are their Key Business plans in the Global CO2 Incubators market? What are the key concerns of the five forces analysis of the Global CO2 Incubators market? What are different prospects and threats faced by the dealers in the Global CO2 Incubators market? What are the strengths and weaknesses of the key vendors?

Read Detailed Index of full Research Study at @ https://www.advancemarketanalytics.com/reports/3431-global-co2-incubators-market-2 Customization Service of the Report:-AMA Research provides customization of reports as per your need. This report can be personalized to meet your requirements. Get in touch with our sales team, who will guarantee you to get a report that suits your necessities.

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

About Author:

Advance Market Analytics is Global leaders of Market Research Industry provides the quantified B2B research to Fortune 500 companies on high growth emerging opportunities which will impact more than 80% of worldwide companies revenues.

Our Analyst is tracking high growth study with detailed statistical and in-depth analysis of market trends & dynamics that provide a complete overview of the industry. We follow an extensive research methodology coupled with critical insights related industry factors and market forces to generate the best value for our clients. We Provides reliable primary and secondary data sources, our analysts and consultants derive informative and usable data suited for our clients business needs. The research study enable clients to meet varied market objectives a from global footprint expansion to supply chain optimization and from competitor profiling to M&As.

Craig Francis (PR & Marketing Manager)AMA Research & Media LLPUnit No. 429, Parsonage Road Edison, NJNew Jersey USA 08837Phone: +1 (206) 317 1218[emailprotected]

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International Women’s Day 8 March: LKF conducts research on women’s health with women leading the way – marketscreener.com

CO2 Incubators Market Update: Uncover the Business Strategies of Leaders & Laggards of the Market – 3rd Watch News

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