Image caption Matthew Wood hopes the gene therapy will help him keep his remaining vision

A new gene therapy has been used to treat patients with a rare inherited eye disorder which causes blindness.

It's hoped the NHS treatment will halt sight loss and even improve vision.

Matthew Wood, 48, one of the first patients to receive the injection, told the BBC: "I value the remaining sight I have so if I can hold on to that it would be a big thing for me."

The treatment costs around 600,000 but NHS England has agreed a discounted price with the manufacturer Novartis.

Luxturna (voretigene neparvovec), has been approved by The National Institute for Health and Care Excellence (NICE), which estimates that just under 90 people in England will be eligible for the treatment.

The gene therapy is for patients who have retinal dystrophy as a result of inheriting a faulty copy of the RPE65 gene from both parents. The gene is important for providing the pigment that light sensitive cells need to absorb light. Initially this affects night vision but eventually, as the cells die, it can lead to complete blindness.

An injection is made into the back of the eye - this delivers working copies of the RPE65 gene. These are contained inside a harmless virus, which enables them to penetrate the retinal cells. Once inside the nucleus, the gene provides the instructions to make the RPE65 protein, which is essential for healthy vision.

Matthew Wood started losing his sight as a child, and is now registered blind. However, he does have some peripheral vision and can detect large objects and bright lights. He told the BBC: "Since I was a child I was continually told there was no treatment for this condition, so it's amazing to receive this gene therapy."

Mr Wood, from London, had his right eye treated during an hour-long operation at the John Radcliffe Hospital in Oxford.

His left eye will be injected in a few weeks. The surgery was carried out by Prof Robert MacLaren, who has pioneered research into gene therapies for preventing blindness.

He told the BBC: "This is very exciting - this is the first approved NHS gene therapy for an eye disease, but there are opportunities to use gene therapy to treat other diseases in future, not only in the eye."

The treatment is only suitable for patients who have some remaining vision. It should bring the biggest benefits to children with RPE65 retinal dystrophy, as it could halt sight loss before permanent damage is done.

It is not known how long the benefits of the treatment will last, but it's thought it could be several decades.

Jake Ternent, 23, from Durham, had his gene therapy at Moorfields Eye Hospital in London.

Like Matthew Wood, he is registered blind, but has some limited sight. He told the BBC: "I hope the treatment could improve my night vision, and possibly even my day vision, which would be incredible. I feel lucky and privileged to get this on the NHS."

Prof James Bainbridge - from Moorfields Eye Hospital - who treated Jake, told the BBC: "To be at the point now where we are able to offer this treatment on the NHS, is truly remarkable. This is the first example of what's anticipated to be a whole new generation of treatments."

It will take a month or two before Matthew and Jake know what changes the gene therapy has made to their vision. But even if it simply prevents further sight loss, both say they will be delighted.

Professor Stephen Powis, NHS medical director, said: "Loss of vision can have a devastating effect, particularly for children and young people, but this truly life-changing treatment offers hope to people with this rare and distressing condition."

Follow Fergus on Twitter.

Link:
Gene therapy to halt rare form of sight loss - BBC News

Bill Gates

Microsoft founder Bill Gates thinks artificial intelligence and gene therapy are the two technologies with the greatest power to change lives. In a speech Friday at the American Association for the Advancement of Science, Gates said AI can "make sense of complex biological systems," while gene-based tools have the potential to cure AIDS.

The potential of AI is only just being realized now, the billionaire philanthropistsaid, with computational power doubling every three and a half months. Along with improvements in handling data, Gates said it's enabling "the ability to synthesize, analyze, see patterns, gain insights and make predictions across many, many more dimensions than a human can comprehend."

Gates said the most exciting part of AI "is how it can help us make sense of complex biological systems and accelerate the discovery of therapeutics to improve health in the poorest countries."

Gene-editing technologies will meanwhile help with vaccines, diagnostics and therapeutics, Gates said. "[It] has the potential to improve health -- not only for rare genetic disorders, but also for diseases that predominately afflict people in poor countries."

Gates also addressed the deadly coronavirus, saying these two technologies could help with diagnostic tests, treatment and vaccine development.

"Our foundation has committed up to $100 million to address this new coronavirus because we believe it poses a serious threat to global health," Gates said. "This money will support efforts to detect, isolate and treat confirmed cases, help countries in sub-Saharan Africa and South Asia take steps to prepare for the epidemic and protect their most vulnerable citizens, and accelerate the development of vaccines, treatments and diagnostics."

Read more from the original source:
Bill Gates: AI and gene therapy have the power to save lives - CNET

The incidence of cancer has increased tremendously in the past few years. With advancements in science and technology, the treatment for cancer has become efficient and affordable. However, there are some rare and complicated forms of cancer that require better treatments to increase success rates. Recently, cancer gene therapy has showed promising results in preclinical trials. This is a promising trend for the global cancer gene therapy market.

Gene therapy is a method of adding or replacing a gene in an organisms DNA. In some forms of cancer, there is a defective or malfunctioning gene. Nucleic acid is administered to an individual like a drug to correct the gene sequence. Globally, there is a huge thrust on gene therapy research, and it is boosting the growth in the cancer gene therapy market.

Key driving factors of the global cancer gene therapy market

Chemotherapy and radiation, along with surgery are some of the prominent treatments available for cancer today. In cases of early detection, doctors recommend surgery along with chemotherapy or radiation. But, if the cancer has metastasized (spread to other organs), then surgery is difficult. This calls for advanced treatments, a positive factor for the global cancer gene therapy market

While chemotherapy has its own advantages, it has several side effects on the patients. It causes weight loss, vomiting, hair loss, nausea, and other complications in the body. That is the reason why doctors are better treatment options. This is a boost for the global cancer gene therapy market

Radiation also has severe impact on the body. It may cause hair loss, nausea, vomiting, fatigue and skin problems depending on the area of radiation. It also results in lung and heart problems. These factors are favorable for the global cancer gene therapy market

The survival rate of some cancers like lung, pancreatic, and liver is very less. Their chemotherapy treatments have severe side effects. Researchers feel that cancer gene therapy can improve the quality of the treatment. These findings are pushing the demand in the global cancer gene therapy market

With promising in vivo (laboratory) results, many pharmaceutical companies have embarked upon research to develop cancer gene therapy. Investments in R&D have soared in the past few years, a welcoming trend for the global cancer gene therapy market

Cancer has become more prevalent than ever today. With rising number of people seeking treatment for this disease, the demand for quality treatment is expected to grow in the coming years. This is a prime growth factor for the global cancer gene therapy market

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Global Cancer Gene Therapy Market: Key Segments

Based on type, the cancer gene therapy market is segmented into gene transfer immunotherapy and oncolytic virotherapy. Immunotherapy uses genetically modified cells and viral particles to stimulate the immune system to destroy cancer cells. Immunotherapy include treatment with either cytokine gene delivery or tumor antigen gene delivery.

Oncolytic virotherapy uses viral particles, which replicate within the cancer cell causing the death of the cell. It is an emerging treatment modality that is expected to shows great promise, particularly in metastatic cancer treatment. It includes treatment with adenovirus, retrovirus, lentivirus, herpes simplex virus, adeno-associated virus, simian virus, alphavirus, and vaccinia virus.

Gene transfer is the newest treatment modality that is expected to introduce new modified genes into cancerous cell or associated tissue for destruction of cell or to slow down cancer growth. This technique is flexible as a wide variety of vectors and genes are used for clinical trials with positive outcomes. As gene therapy advance, they could be used alone or in combination with other treatments to control the disease. Gene transfer or gene replacement is performed using naked/plasmid vectors, electroporation, sonoporation, magnetofection, and gene gun.

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Global Cancer Gene Therapy Market: Regional Analysis

Based on region, the global cancer gene therapy market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa. North America is anticipated to hold the largest market share. The U.S. dominates the cancer gene therapy market owing to its increase in funding for research & development and other government initiatives.

Key players in the biotech industry are engaging in research & development of gene therapy products. Moreover, rising demand for DNA vaccines and growing interest of venture capitalists to investment in commercialization of gene-based cancer therapies are likely to propel the market. The cancer gene therapy market in Asia Pacific is anticipated to expand at a rapid pace as in China cancer gene therapy is anticipated to attribute for largest revenue, due to the recent launch of Gendicine and rising healthcare expenditure with strong R&D facilities.

Global Cancer Gene Therapy Market: Key Players

Key players operating in the global cancer gene therapy market are Adaptimmune, ZioPharm Oncology Altor Bioscience, MolMed, bluebird bio, Shanghai Sunway Biotech Company limited, MultiVir, Shenzhen SiBiono GeneTech, and Corporation.

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Read the original:
Promising In Vitro Results to Fillip Global Cancer Gene Therapy Market - BioSpace

Researchers at the University of Pennsylvania and Childrens National Hospital in Washington, DC utilized a hybrid approach that combined gene therapy with gene editing to treat a rare genetic disease in animal models, making it convert into a milder, more treatable form of the disease. The disease was ornithine transcarbamylase deficiency (OTCD), which is the most common type of a family of illnesses called urea cycle disorders.

Urea cycle disorders affect about 1 in 30,000 individuals. It causes problems in how the body metabolizes proteins in food. Normally, proteins are broken into individual amino acids. The body then recycles those amino acids to create new proteins for the body to use. Extra proteins are metabolized for energy, which requires a chemical category called amines to be removed, which are converted into ammonia. Ammonia is toxic to cells. In healthy people, urea cycle enzymes from the liver convert ammonia into urea, which is harmlessly excreted in urine.

When people have urea cycle disorders, ammonia builds up, causing vomiting and lethargy. If untreated, it can cause coma and death.

The various urea cycle disorders are caused by various genetic mutations. The researchers, led by James M. Wilson at the University of Pennsylvania and Mark L. Batshaw at Childrens National, originally attempted a typical form of gene therapy in animal models, inserting a properly functioning version of the OTC gene into a virus that carries the code for the missing enzyme, ornithine transcarbamylase.

This approach worked in older animals but did not last long in newborn animals because of rapid liver growth. CRISPR/Cas9 gene editing, on the other hand, can be used to modify the genes. Alone, this is a problem for OTCD because there are more than 400 different known mutations that cause it.

For their new approach, which they described in the journal Science Advances, they developed a viral vector that carried an enzyme that creates a targeted break in DNA. This step is typical in standard gene editing. But, instead of correcting the mistake, a second vector that carried a copy of the correct OTC gene sequence was used simultaneously.

In their experimental animal models of newborn animals, the gene integrated into cells and spread in patches in the animals livers as they grew. They produced more and more of the necessary detoxifying enzyme as they grew. They then tested nitrogen loads on the animals, and the ones who had been treated with the combined strategy had approximately 60% lower ammonia levels in their blood compared to untreated animals. All of the treated animals survived a seven-day test, while only a quarter of the untreated animals survived.

Theoretically, this could be a curative approach for OTCD, Batshaw said. And if it worked for that, we could create similar templates to treat other related disorders.

Currently, treatment for the disease includes a very low protein diet, drugs that scavenge nitrogen from the blood or a liver transplant in the most serious cases. Through these therapies, weve turned this fatal disease into a chronic one for most patients, Batshaw said. But theres still no curative approach other than liver transplantation.

The research isnt quite ready for human studies, but it is promising.

Read the original post:
Hybrid Gene Therapy Approach Shows Promise in Treating Metabolic Diseases - BioSpace

A University of Delaware professor is receiving grant funding to develop a new therapy for people with low blood platelet counts and other blood disorders.

When patients dont have enough blood platelets, they cant form clots and this can sometimes be a lethal condition. These patients rely on platelet donations as a treatment, but those are often in short supply since they cannot be frozen and are only good for a few days.

A few years ago, UDs professor of Chemical and Biomolecular Engineering Terry Papoutsakis discovered a way to get patients to produce more blood platelets in their own bloodstream by introducing microparticles made from cultured stem cells.

These microparticles can be frozen to be used on a large scale. And Papoutsakis says they could also be used to treat genetic blood disorders like primary immune deficiencies.

To be able to use those particles for applications in gene therapy for a variety of blood diseasesa lot of genetic diseases or acquired diseases for patients, said Papoutsakis. So thats a difficult problem to deal with and we think this has great promise.

Papoutsakis is being awarded $250,000 through a partnership between University City Science Center and CSL Behring meant to find new biotherapies. He says the award took a few years to secure as a result of contract negotiations around intellectual property rights.

It took a little while to do it, but that is to be understood that it would, because of the potential that this might develop into something quite bigger than we currently see, he said.

Papoutsakis says he has already had some success testing his discovery on mice. He says the award will fund a continuation of those tests, moving the therapy closer to clinical trials on human patients.

Read the original:
UD professor working to use gene therapy to treat blood disorders - Delaware First Media

In 2018, Pfizer initiated a Phase Ib clinical trial of its gene therapy treatment for Duchenne muscular dystrophy (DMD). The AAV9 gene therapy, PF-06939926, is designed to provide DMD patients with a form of the dystrophin gene at the root of the condition, thereby countering the progressive muscle degeneration and weakness that characterizes the disease.

Pfizer planned to dose 15 patients with the gene therapy, which must be stored at -70C. In light of those factors, Pfizer opted for a patient-led supply model that would only ship product once a subject was enrolled and ready for treatment.

The model made the lag between a site requesting and receiving product critical, as during that time patients with a progressive disease would be waiting for a potentially beneficial treatment. Pfizers goal was to package and ship the gene therapy to patients within two weeks.

That goal created challenges. Typically, the lag between the ordering and shipment of trial materials is six to eight weeks. Almac had already reduced that lead time by applying LEAN packaging and labelling principles but needed to shave a further two weeks off to meet Pfizers demands.

To do so, Almacs clinical services unit developed a dedicated packaging and labelling process. The process, which Almac executed at its US facility in Souderton, Pennsylvania, resulted in a 12-day lead time for the first patient enrolled in the trial.

Almac provided the packaging specification within two business days. Pfizer granted approval in one working day. Packaging and labelling took place four to five days after receipt of the initial request.

The case study presented by Almac covers the shipment of a gene therapy to a single patient. Yet, the process it describes has broader relevance for drug developers and contract packagers in an era defined by therapies targeting small patient populations.

In the four years preceding late 2019, the number of clinical trials of advanced therapy medicinal products (ATMP), such as cell and gene therapies, increased by two thirds, according to data tracked by the Alliance for Regenerative Medicine. Many ATMPs place new pressures on supply chains, which are adapting to quickly get medicines to patients.

See the rest here:
Almac and Pfizer slash gene therapy labeling times - OutSourcing-Pharma.com

The lottery that began [recently] was not about money, or about choosing a school, or about obtaining a visa. It was about a childs life. In this case, the children selected would receive a drug that otherwise was not available.

The treatment, a gene therapy calledZolgensma, is designed for children like Wynter who have a neuromuscular disease called spinal muscular atrophy, or SMA.

The lotterywas devised by the drugs manufacturer, Novartis, to give families in those places a chance to get it through a novel form of compassionate use a way to get medications that have not been approved while they wait. Fifty doses are slotted to be given away for free in the first half of the year, with up to 100 total.

Ethicists and advocates have debated the merits and the design of the unusual arrangement. Parents said that it was uncomfortable to cast their childs fate into what felt like a sweepstakes a kind of bizarre Willy Wonka contest in which, as Maura Blair, a Canadian mother of a child with SMA put it, were talking about lives.

Zolgensma costs $2.1 million in the United States the worlds most expensive drug.

Read the original post

More here:
Unconventional drug 'lottery' will hand out 50 doses of Zolgensma, world's most expensive gene therapy - Genetic Literacy Project

IRVINE, Calif., Feb. 14, 2020 (GLOBE NEWSWIRE) -- ClearPoint Neuro, Inc. (Nasdaq: CLPT) (the Company), a leading platform neurosurgery company, today announced a strategic agreement with PTC Therapeutics, Inc. (PTC). The scope of the agreement includes hardware, software, clinical case and market development services for gene therapy cases in the United States and Europe to support PTCs potential commercialization in gene therapy globally upon regulatory approval. In addition to the announcement of this agreement, ClearPoint Neuro today announces the following 2020 Outlook for the companys performance:

We have put a tremendous amount of thought and effort into redefining our Company over the past two years, commented Joe Burnett, President and CEO of ClearPoint Neuro, Inc. This has included the vision, the team, the partnerships, and even the name of our company which officially changed this week to ClearPoint Neuro from MRI Interventions. We are thrilled by the evolution our Company has already undergone and believe we have only scratched the surface of the significant potential ahead.

We have evolved to become two companies in one, continued Burnett. On one side, we are a platform medical device company, consistently delivering double digit growth, and continuing to expand our installed base of neurosurgery centers in the U.S. Every year more surgeons and more patients gain access to the ClearPoint system and compatible disposable devices. On the other side of the business, we are a gene therapy and biologics enabling company, providing navigation, drug delivery, and case support to more than 20 companies in this exciting and growing space. Here we currently support pre-clinical and clinical efforts, but we believe that we are on the precipice of potentially explosive growth as these therapies progress through the regulatory process toward commercial launch. We feel that our company represents both scale and purpose through a unique combination of predictable device growth and a potential biologics opportunity, all supported under a common team dedicated to treating the most debilitating neurological disorders.

ClearPoint Neuros revenue outlook for 2020 includes an expectation that approximately 33% of total revenue will be derived from biologics and drug delivery products and services, up from approximately 20% in 2019, and reflecting the growth of this part of the business.

When planning for the development and potential commercialization of gene therapy globally, safety, consistency and predictability are crucial constructs that all must be included, commented Marcio Souza, Chief Operating Officer of PTC Therapeutics and ClearPoint Neuro Board Member. Our agreement with ClearPoint Neuro is designed to provide standardization across all of our centers of excellence as we can maintain consistency in navigation, delivery and clinical support. The more variables we can control, the more successful we believe the outcomes for patients will be.

As part of our Companys duality in devices and biologics, we are thrilled to deepen our partnership with PTC, commented Jacqueline Keller, Vice President and Program Manager at ClearPoint Neuro for the PTC Partnership. This new agreement with PTC highlights a turn-key solution for our gene therapy partners, whereby our commercial organization, with deep relationships in the neurosurgery community, can take on the burden of sales and clinical activities in the surgical suite, and allow our partners who are commonly small-molecule focused companies to continue to prioritize their efforts with neurologists, patients and reimbursement administrators. With the capacity to support thousands of cases each year, our team plans to provide this service across multiple companies and indications in neuro.

About the Company

The Companys mission is to improve and restore quality of life to patients and their families by enabling therapies for the most complex neurological disorders with pinpoint accuracy. Applications of the Companys current product portfolio include deep-brain stimulation, laser ablation, biopsy, neuro-aspiration, and delivery of drugs, biologics and gene therapy to the brain. The ClearPoint Neuro Navigation System has FDA clearance, is CE-marked, and installed in 60 active clinical sites in the United States. The Companys SmartFlow cannula is being used in partnership or evaluation with more than 20 individual biologics and drug delivery companies in various stages from preclinical research to late stage regulatory trials. To date, more than 3,500 cases have been performed and supported by the Companys field-based clinical specialist team which offers support and services for our partners. For more information, please visit http://www.clearpointneuro.com.

Note on Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 regarding the planned offering. Additionally, all statements relating to any closing(s) of, and the amount or use of any proceeds from, the transactions described in this press release are considered to be forward-looking statements. Other forward-looking statements may be identified by the words guidance, plan, anticipate, believe, estimate, expect, intend, may, target, potential, will, would, could, should, continue, and similar expressions. Forward-looking statements are subject to risks and uncertainties, and the Companys actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of such risks and uncertainties, which include, without limitation, risks and uncertainties associated with market conditions and the satisfaction of closing conditions related to the transactions described in this press release. There can be no assurance that the parties will be able to complete the transactions described in this press release on the terms described herein or in a timely manner, if at all. More detailed information on these and additional factors that could affect the Companys actual results are described in the Risk Factors section of the Companys Annual Report on Form 10-K for the year ended December 31, 2018, and the Companys Quarterly Reports on Form 10-Q for the periods ended March 31, 2019, June 30, 2019 and September 30, 2019, all of which have been filed with the SEC, as well as the Companys Annual Report on Form 10-K for the year ended December 31, 2019, which the Company intends to file with the Securities and Exchange Commission on or before March 30, 2020. You are urged to carefully consider all such factors. Copies of these and other documents are available from the Company. The forward-looking statements contained herein represent the Companys views only as of the date of this press release the Company does not undertake or plan to update or revise any such forward-looking statements to reflect actual results or changes in plans, prospects, assumptions, estimates or projections, or other circumstances occurring after the date of this press release except as required by law.

For More Information

ClearPoint Neuro, Inc.Matt KrepsDarrow Associates Investor Relations(214) 597-8200mkreps@darrowir.com

Read more:
ClearPoint Neuro, Inc. Announces 2020 Revenue Outlook Ahead of Nasdaq Investor Presentation TodayNew US and European Partnership Agreement with PTC...

Dianomi Therapeutics is expanding the use of its patented drug delivery system to include gene therapies.

This comes after licensing a second set of intellectual property from WARF.

The Madison-based startup is developing a technology known as mineral-coated microparticles, which can stabilize and control the release of therapeutic drugs and improve their effect. A release shows the MCM technology shares a capacity for biological molecule storage with human bones and teeth.

The MCM technology was developed by UW-Madisons William Murphy, a professor of biomedical engineering and co-founder of Dianomi. He created the technology in hopes of improving upon artificial polymer-based drug delivery systems, which have more limited function.

Dianomi has demonstrated success in developing and optimizing MCM delivery for biologics and other small molecules, Murphy said in a release. I look forward to Dianomis expansion into the area of nucleic acid therapy, building upon the early results of our nucleic acid delivery in regenerative medicine applications.

Researchers have demonstrated favorable results with the MCM technology combined with nucleic acids, the release shows. Early animal studies have shown improvement in the delivery of these genetic materials, promising a potentially potent and sustained therapeutic effect.

The new gene therapy application builds on the companys first product, which delivers therapeutic drugs over time to patients with osteoarthritis. According to the release, company leaders plan to continue developing other applications for the companys drug delivery method. Targets include heart health, cancer treatment, vaccines, regenerative medicine, neuromuscular and spinal degeneration, and more.

This new suite of intellectual property expands the capability of Dianomis core technology into new indications and markets having significant commercial and clinical interest, said Martin Ostrowski, chief operations officer and general counsel of Dianomi.

The newly licensed IP from the Wisconsin Alumni Research Foundation includes issued U.S. patents and pending U.S. and international patent applications.

Dianomi Therapeutics is based in FORWARD Biolabs, part of UW-Madisons Forward BIO Institute. Murphy, Dianomis chief science officer, is the institutes director.

See an earlier story on the company: http://www.wisbusiness.com/2018/forward-bio-institute-awarded-5-million-nih-grant/

By Alex Moe

WisBusiness.com

More:
Dianomi Therapeutics expanding drug delivery system - Wisbusiness.com

PharmaSphere: Emerging Biotechnologies-Gene Therapy Market research now available at Brand Essence Research encompasses an exhaustive Study of this business space with regards to pivotal industry drivers, market share analysis, and the latest trends characterizing the PharmaSphere: Emerging Biotechnologies-Gene Therapy industry landscape. This report also covers details of market size, growth spectrum, and the competitive scenario of PharmaSphere: Emerging Biotechnologies-Gene Therapy market in the forecast timeline.

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The well-established players in the market are:

Advantagene, Amarna Therapeutics, AnGes MG, Inc., Applied Genetic Technologies Corporation, AskBio, Avalanche, Bluebird bio, Celladon Corporation, Dimension Therapeutics, American Gene Technologies International Inc,

This report for PharmaSphere: Emerging Biotechnologies-Gene Therapy Market discovers diverse topics such as regional market scope, product market various applications, market size according to specific product, sales and revenue by region, manufacturing cost analysis, Industrial Chain, Market Effect Factors Analysis, market size forecast, and more.

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The report segments the PharmaSphere: Emerging Biotechnologies-Gene Therapy market into USA, Europe, Japan, China, India, South East Asia depending on the regional scope of this business

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There are 15 Chapters to deeply display in the GlobalPharmaSphere: Emerging Biotechnologies-Gene Therapy market.

Chapter 1, to describePharmaSphere: Emerging Biotechnologies-Gene Therapy Introduction, product scope, market overview, market opportunities, market risk, market driving force;

Chapter 2, to analyze the top manufacturers ofPharmaSphere: Emerging Biotechnologies-Gene Therapy , with sales, revenue and price ofPharmaSphere: Emerging Biotechnologies-Gene Therapy , in 2017 and 2018;

Chapter 3, to display the competitive situation among the top manufacturers, with sales, revenue and market share in 2017 and 2018;

Chapter 4, to show the Global market by regions, with sales, revenue and market share ofPharmaSphere: Emerging Biotechnologies-Gene Therapy , for each region, from 2013 to 2018;

Chapter 5, 6, 7, 8 and 9, to analyze the key regions, with sales, revenue and market share by key countries in these regions;

Chapter 10 and 11, to show the market by type and application, with sales market share and growth rate by type, application, from 2013 to 2018;

Chapter 12,PharmaSphere: Emerging Biotechnologies-Gene Therapy market forecast, by regions, type and application, with sales and revenue, from 2019 to 2024;

Chapter 13, 14 and 15, to describePharmaSphere: Emerging Biotechnologies-Gene Therapy sales channel, distributors, traders, dealers, Research Findings and Conclusion, appendix and data source.

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Research report explores the PharmaSphere: Emerging Biotechnologies-Gene Therapy Market Size 2019 to 2025 - Instant Tech News