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The (over) promise of the mindfulness revolution – San Francisco Chronicle

Posted: February 7, 2020 at 2:41 pm

The phones screen turns a serene blue, and Calm, the leading mindfulness application, opens. At the very center, without capitalization or punctuation, small and faint, are the words take a deep breath.

That gives way to a menu. What brings you to Calm?

The app offers options to reduce anxiety, develop gratitude, build self esteem, even increase happiness.

The next screen offers a seven-day free trial. Once the trial has ended, the annual rate is $69.99, a small price for happiness.

Somewhere around 2010, according to experts and Google search data, the practice of mindfulness began an upward swing. In less than a decade, it has become the fastest-growing health trend in the United States, according to the federal Centers for Disease Control and Prevention. Mindfulness rules the online app store. The San Francisco-based Calm is valued at $1 billion, and its competitor Headspace at $350 million. (The industry as a whole has been estimated to be worth as much as $4 billion.) Meditation retreats are en vogue. Corporations offer access to mindfulness in the same way they do for gyms. Even the military uses mindfulness breathing techniques to boost soldiers performance.

But as with any Next Big Thing, there are reasons to be cautious. Some say this rush into mindfulness has outpaced the science and stripped it of its cultural context. All of this threatens to turn a tool for well-being, for situating oneself in the current moment, into a tool for standard American commercialism.

Around the same time mindfulness began its upward trajectory, Ronald Purser, a management professor at San Francisco State University, started to feel the familiar weight of doubt. Hed been doing a fair amount of corporate management training and consulting redesigning the workplace to work better, at least in theory, for everybody. I became somewhat disillusioned and disenchanted, he says. Even when we were making progress, trying to redesign work so employees would have more autonomy and decision-making, the management sort of pulled the plug on some of those experiments.

It was around this time, too, that Chade-Meng Tan, a software engineer at Google, gained notoriety for integrating mindfulness into Googles corporate culture through a series of in-house mindfulness seminars. In 2012, Tan turned those courses into a blockbuster book, Search Inside Yourself: The Unexpected Path to Achieving Success, Happiness (and World Peace), and Purser found himself attending Tans very first public offering.

I became very disappointed by what I saw, just in terms of what the program was and how superficial it was, Purser says. I just saw this as part of the interest in behavioral science techniques as a way of yoking the interest or subjectivity of employees to corporate goals.

A year later, Purser published an essay with the Huffington Post. It was titled Beyond McMindfulness. Mindfulness meditation, he wrote, was making its way into schools, corporations, prisons, and government agencies including the U.S. military. Purser, a student of mindfulness for 40 years, wasnt knocking the practice but was wary of its growing reputation as a universal panacea for resolving almost every area of daily concern. Last year, Purser expanded on the essay and published a book titled McMindfulness: How Mindfulness Became the New Capitalist Spirituality.

Early on in his book, he writes this: I do not question the value of adapting mindfulness for therapeutic use, nor do I deny that it can help people. What bothers me is how its promoters want things both ways: one minute, mindfulness is science, since thats what sells; the next, it stands for everything in Buddhism, since thats what makes it sound deep.

The issues Purser called out eight years ago have only grown with time. Rhetoric, he says, still outpaces results. The practice becomes increasingly decontextualized, meme-ified and gamified. Mindfulness becomes a cure for more and more our happiness, our anxiety, our pain, even world peace.

Its worth pausing a moment to define or at least try to define mindfulness.

At its very core, its deepest and truest roots, mindfulness is a Buddhist meditation technique. There are hundreds, probably thousands of different meditative techniques. This is only one of them, says Mushim Ikeda, a Buddhist meditation teacher. Traditionally, in the Buddhist scriptures, it is said that what we call mindfulness meditation was one of 40 different techniques that the historical Buddha, the one we call the Buddha, talked about. So it wasnt even his one and only meditation technique according to those scriptures.

She knows those scriptures well. Ikeda, who primarily teaches at the East Bay Meditation Center, describes herself as a socially engaged teacher a social justice activist, author, and diversity and inclusion facilitator.

She describes mindfulness meditation as a secular term in Buddhism, one thats also called insight meditation. This is a sort of awareness, she says, that is different from the awareness that we might call everyday awareness the sort we need to drive a car, or maintain a conversation, or use an ATM. She and others describe mindful awareness as spacious and nonjudgmental. Ikeda says, Its been said mindfulness only sees. It does not judge.

The most common technique involves closing the eyes and focusing on the breath and only the breath, moving other thoughts, and the thoughts that come with those thoughts, away and out.

Mindfulness as a secular, western therapeutic intervention did not begin in Silicon Valley. Rather, youd have to go back to 1979 and a man named Jon Kabat-Zinn and the founding of the Stress Reduction Clinic at the University of Massachusetts Medical School. Kabat-Zinn has studied the effects of what he dubbed mindfulness-based stress reduction (MBSR for short), on everything from brain function to skin disease.

Still, its hard to ignore Silicon Valleys latest role in spreading and expanding mindfulness in the pursuit of a different tech culture value, peak performance. There is Search Inside Yourself, the book that coincided with the movements growth spurt. There are Twitter co-founder Jack Dorseys much-publicized meditation retreats. (Black Mirror, the dystopian science fiction show, seemed to parody both him and the now-ubiquitous apps.) Recently, there was the dopamine fast, a pseudo-scientific dopamine reset by way of doing nothing. (One originator said he drew directly from Buddhist Vipassana meditation when he crafted the fast.)

The voices are soothing and smooth soft, but not quite a whisper. The cadence and diction perfect, gently pulling you along. Birds chatter in the background. Waves move gently to meet a beach. Or maybe a brook babbles as it pushes over and under and between river rocks.

Breathing in ... I am calm.

Breathing out ... I am at peace.

A chime rings, a signal that this 90-second meditation to calm anger has ended. Calm offers its congratulations.

The danger in this rapid evolution is that it threatens to turn a very old practice into a fad that overpromises and underdelivers.

Helen Weng has practiced Buddhist meditation for more than two decades. I was reading a lot of books about psychology because I was unhappy because high school is horrible, she says. And her father, who, along with her mother, had immigrated to the United States from Taiwan, could offer her books about Buddhist philosophy. The two came together. The Dalai Lamas teachings offered her an opportunity to cultivate her own well-being. I dont like the word happiness anymore, but you can use mental exercises to become more aware of your feeling states and your thoughts.

Now Weng works as a clinical psychologist with the psychiatry department at UCSF and a neuroscientist with the Osher Center for Integrative Medicine and the Neuroscape Center, both at UCSF as well. Her scientific work uses magnetic resonance imaging to measure the amount of oxygen in the blood that flows to the brain as people meditate. Essentially, she can track whether the meditator is actually focused on their breath or if their attention has wandered. And in her clinical work, she offers meditation as one of many possible therapeutic interventions.

Still, she calls the recent spread of mindfulness very freaky.

Im very proud that practices from eastern cultures and religions generate so much interest, she says. At the same time, mindfulness and its results are super hard to study. So much so that I just thought I was a bad scientist for a long time. Whats more, she says, meditation isnt always the right sort of behavioral therapy.

Im very disturbed by these messages that meditation basically cures everything or its good for everyone or theres universally very good positive effects. The effects are really moderate and subtle. Its not any better than any other kind of psychotherapy, she says. Part of it is cultural appropriation where its this magical, mystical thing that then people can say does all these things, and I think were still in the height of that and its going to take some time for things to settle down.

Medical students, she says, inevitably ask her how much time they have to commit to mindfulness to make it work. There are studies that show clear benefits to mindfulness. Weng points to one that indicated 30 minutes a day of compassion meditation for two weeks increased altruistic giving to strangers and brain responses to pictures of people suffering.

But the key here is consistency. What happens if you work out for 30 minutes just once? she asks. It benefits you a little bit. Thats good. But if you just do it once, its not going to have a long-term effect.

After the chime and the congratulations, the waves keep moving in and out, and a quote appears onscreen. Insanity is doing the same thing over and over again expecting different results. (A quote sometimes attributed to Albert Einstein, but probably more correctly attributed to Narcotics Anonymous.) And in that moment, Calm reminds you that you really should turn on push notifications, in order to fully experience Calm. Decline and itll ask one more time about its mindfulness reminders.

Are you sure? Its hard to set aside time for yourself in our busy world without a little help.

Farrah Fawcett and Lee Majors are jogging. Theyre tan, of course. Their shorts are short. Her blond hair is fanned out, so are his brown curls. She has a broad, blindingly white smile and a red handkerchief tied around her neck. His jacket is zipped down almost to his navel; his chest is hairy. And right beside them, a headline: Farrah & Lee & Everybodys Doing It: Stars Join The Jogging Craze.

This is the cover of the July 4, 1977, issue of People magazine. Alex Will, the chief strategy officer for Calm, the industry-leading mindfulness meditation app, likes to reference this cover when he talks about mindfulness. (Theres even a copy of the issue at the office.) To understand the future of mindfulness, just look to the past.

Mindfulness is becoming mainstream, Will says. People are starting to understand that taking care of the mind is just as important as taking care of the body. Meditation and mindfulness is one way to do that.

In some respects, Calm isnt doing anything that hasnt already been done. Before smartphones, one could buy a meditation CD, slip it into a home stereo and start counting breaths. The app just makes it more portable and more accessible than ever before. I think one of the reasons Ive been so successful is that it is a very low bar for someone to try and get into, Will says. There are short, two-minute long meditations, narrations to help with sleep, even a beginners guide to mindfulness. Similarly, if you want to go deeper, we have a 30-minute master class where you can learn how to break bad habits.

All of the content, Will says, is vetted by mindfulness instructors, and, now that the app is available in more than 100 countries, the programming is also run by people to make sure translations work. This is very nuanced, he says. Language really matters. The Calm app has also been part of various clinical studies in an attempt to back up the applications rhetoric.

Mindfulness, by the way, has already had its magazine-cover moment. Not quite 37 years after the jogging craze, Time magazine featured the Mindfulness Revolution on its Feb. 3, 2014, issue. A blond, fair-skinned model stands straight, hands at her sides, eyes closed, face slightly upward. And the headline: The science of finding focus in a stressed-out multitasking culture.

Mindfulness began to trend in large part because corporations embraced the practice as a way to help employees relieve stress. This is one of the cruxes of Pursers concerns that mindfulness is just a way to wring more productivity from employees, a sleight of hand that shifts the onus from the company to the worker.

In 2012, the year Chade-Meng Tan published Search Inside Yourself, the idea of offering mindfulness courses to employees still felt novel. The New York Times featured Tan and the course hed developed for Google employees a course that involved meditation, Tibetan brass bowls, stream-of-consciousness journaling and lots of emotional openness. Even then the course was framed as a way to help employees deal with their intense workplace no mention of toning down the intensity.

Eight years later, mindfulness courses are the rule, not the exception. Apple, Nike, HBO and Target have all offered some form of mindfulness training to employees. Aetna, the insurance provider, decided to offer mindfulness and other stress-relief activities (including dog petting) after an internal study found that the most stressed-out employees spent $1,500 more a year on health care. And if a company cant bring a trained expert on board, well, they can always give employees memberships to Calm or Headspace.

The Buddha taught that almost everything comes and goes, says Muslim Ikeda, the East Bay Meditation Center instructor. Its called impermanence or change. And health trends famously come and go. Its a product of our capitalist system.

One year, its a certain kind of berry thats going to cure everything. Another year, its mindfulness meditation thats going to cure everything. Five years from now, heaven only knows, itll be something else. Burnt toast who knows?

Ikeda offers a path forward, a path separate from capitalism, a path that encourages students to cultivate a practice in which they care for themselves so that they may, in turn, care for their communities. Its an approach based in social justice and altruism. And yet, she isnt dogmatic.

Mindfulness, Ikeda says, does not judge.

A person might use mindfulness to lower their blood pressure or achieve peak performance. A corporation might use mindfulness to paper over an inherently unjust and healthy system. All this, she says, is like using a Swiss Army knife for just one thing. Its not what the tool was intended to do, and its not all it can do.

Mindfulness is always mindful awareness of something, Ikeda says. Who knows what a given individual is going to do with it? Or what it will do for them?

An individual might, for instance, become mindfully aware of a broken system.

Ryan Kost is a San Francisco Chronicle staff writer. Email: rkost@sfchronicle.com. Twitter: @RyanKost

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Continuing to work while going through cancer treatment? These tips can help – telegraphherald.com

Posted: February 7, 2020 at 2:41 pm

The diagnosis of cancer can turn your life upside down in a matter of minutes.

It is a life-altering experience that can be a cause for a lot of stress on the individual who received the diagnosis, as well as family members and caretakers. There are many things to think about when the diagnosis is made, including whether or not youll need to continue working throughout your treatment.

Holistic therapies can aid in the reduction of stress and ease the side effects of treatment if having to work while going through cancer.

Having cancer does not necessarily mean that you will have to stop working. Most likely you will need time off for appointments, treatments or extra rest. You might decide to work as much as possible or take a leave of absence and return when you feel up to it. Or you might have to continue to work for financial reasons and/or health insurance benefits.

One benefit of working while going through cancer is that going to work can help you feel more normal.

If you decide to continue working, it could take some adjusting. Your body might respond differently to normal activities when you have cancer or are going through treatment. You might feel tired, more stressed, have pain or difficulty thinking or remembering things.

Something to consider during this trying time are the benefits of integrative health. Integrative health is the unity of conventional and holistic medicine. It is a healing-oriented model that considers the whole person body, mind, spirit and lifestyle. It uses all appropriate therapies, both conventional and alternative, and focuses on the needs, values and well-being of the person.

Here are some holistic measures to help reduce stress and side effects of treatment:

Conserve energy. Take short breaks as needed throughout your workday to keep your energy up.

Be mindful of your innermost desires and acclimate optimism into your daily thoughts. Take time for yourself to reflect, soul search and nourish the soul. A positive mental attitude during this trying time can help heal the body and reduce stress.

Consider meditation practices. Meditation clears space in your head. Apps such as Insight Timer and Headspace are great places to start.

Use reminder lists and alarms to remember your meetings or tasks. Write a list of tasks that need to be completed for the day. A daily planner, Post-it Notes or use of a smartphone might be helpful tools. Set alarms to help remind you of the tasks that need to be accomplished.

Be open and honest about your situation. Talk with your manager about any concerns. Share your feelings and concerns with your family members and health care team.

Fuel your body with good nutrition. This will help to provide optimal energy throughout the day. A dietitian with experience in oncology nutrition can help you develop a plan.

Consider using essential oils. Aromatherapy can help ease anxiety, pain and nausea symptoms. A clinical aromatherapist can help guide you on which essential oils would be beneficial.

It is important to know your rights. Side effects of cancer treatment are considered disabilities under the American Disabilities Act. Your employer must provide reasonable accommodations according to the American Society of Clinical Oncology. These can include:

Giving you breaks to take medication, see a doctor or rest.

Having you do a job that fits your new hours or abilities better.

Giving you access to counseling through an employee assistance program.

Please remember, you are not in this alone. We live in a wonderful community where people care and want to help in any way they can. Seek out services offered by the community. There are many support groups and valuable resources available to help you and your loved ones through this healing journey.

Jessica Kennedy, BSN, RN, CHC, CMSRN, Jessica is a nurse at MercyOne Dubuque Medical Center.

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Melissa Smith: 5 Fast Facts You Need to Know – Heavy.com

Posted: February 7, 2020 at 2:41 pm

Facebook/PoliceMelissa Smith is accused of murder in the fatal shooting of her husband, Red Bank Police Officer James "Chip" Smith, in Tennessee.

Melissa Smith is a 37-year-old Tennessee woman who has been charged with first-degree murder after police say she shot and killed her husband, Red Bank Police Officer James Smith, during an argument in a parking lot in the Kodak community of Sevierville, Tennessee. James Smith, 41, who went by Chip Smith, was shot in the abdomen about 7:20 p.m. on Saturday, February 2, 2020, and later died at a nearby hospital, the Sevierville Police Department said.

The Red Bank Police Department said in a statement, Our thoughts and prayers go out to Officer Smiths family during this difficult time. Officer Smith has many years of law enforcement service. He honorably and faithfully served this agency and community. We want to take this opportunity to ask for everyones support during this very difficult time. Please keep his family, friends and fellow law enforcement family in your thoughts and prayers.

The Sevierville Police Department said officers responded to a shooting at 3099 Winfield Dunn Parkway, a highway rest stop and visitors center, at 7:23 p.m. on Saturday. The officers found an adult male suffering from a gunshot wound to the abdomen. He was taken to University of Tennessee Medical Center by the Sevier County Ambulance Service and was pronounced dead, police said. Police said a handgun was recovered at the scene and Melissa Smith was taken into custody.

Heres what you need to know about Melissa Smith and the fatal shooting of Red Bank Police Officer James Chip Smith:

Melissa Smith and James Smith.

Melissa Smith told police she was with her husband at the Old Tennessee Distillery Company for about two hours before the argument and shooting occurred and they had been drinking, according to court documents obtained by the Chattanooga Times Free Press. The newspaper reports that officers found Melissa Smith kneeling next to her husband with her hand on his abdomen after the shooting.

Melissa Smith told police she and her husband began arguing in the car after they left the distillery, and James Smith pulled into a parking lot as it escalated, the Times Free Press reported.

The two exited the vehicle and continued to argue until Melissa Smith went back to the vehicle, grabbed a pistol and shot James Smith, the newspaper wrote, citing court documents. Melissa Smith admitted to shooting James Smith with the pistol, according to court records. A .380 semi-automatic pistol was found at the scene.

Melissa Smith and James Chip Smith had been married since August 17, 2002, according to Melissas Facebook page.

The couple has a 14-year-old son together, according to Melissa Smiths Facebook page. They live in Soddy-Daisy.

FacebookMelissa and James Smith.

Chip Smith was arrested on domestic violence charges in 2007 while he was a detective with the Soddy-Daisy Police Department, according to an article in The Chattanoogan from the time.

According to a complaint obtained by The Chattanoogan, James Smith and his wife got into an argument that led to a physical confrontation. Police said Melissa Smith confronted her husband on a marital issue and he grabbed her and threw her across a bed onto their child, the news site reported.

Mrs. Smith said her husband was on top of her and began strangling her with his hands around her neck. She said they began screaming and hitting each other, the news site wrote. Mrs. Smith said she ran into another room and called 911 on her cell phone. She said her husband grabbed the phone from her and hung it up. She said he pushed her down on a couch, but she was able to get away. Officers said they saw injuries to the right side of Mrs. Smiths neck as well as injuries on her left arm.

The case was dismissed in January 2008.

Melissa Marlow Smith works at CHI Memorial Integrative Medicine Associates, a family medical practice in Chattanooga, according to her Facebook profile. It is not clear what her job at the medical practice is.

According to her Facebook page, she was born and raised in Soddy-Daisy, Tennessee, and graduated from Soddy-Daisy High School in 2000, two years before she and Chip Smith married.

Chip Smith is also from Soddy-Daisy, Tennessee, and graduated from Chattanooga State Community College, according to his Facebook page.

The Red Bank Police Department said in a statement posted to Facebook about the death of James Smith that they, lost an outstanding officer and friend yesterday.

James Chip Smith and his son.

The department said, He also served several other law enforcement agencies and communities including the Soddy-Daisy Police Department and Chattanooga Police Department. As a law enforcement officer, he devoted himself to protecting the citizens of these communities. For those that ever met him or know him, they know that he was kind and always willing to do anything to help you. His loss will leave a void at our agency and the law enforcement community.

Chattanooga Police told the Times Free Press, they are ready to provide any patrol or special coverage needed by Red Bank Police Department as they grieve the loss of their officer and friend.

The Hamilton County Sheriffs Office said in a statement, We are saddened by the loss of a fellow officer in such tragic circumstances. Our hearts go out to Chief Seymour and our brothers in blue at the Red Bank Police Department during this very difficult time. Chip has served his community for many years as both a volunteer fireman and law enforcement officer. He will be greatly missed by all who knew him.

On Facebook, the Hamilton County Emergency Medical Service wrote, Chip was both an on duty and off duty friend to many of us here at HCEMS, and we are devastated by the news of his death. Chip was also a well known individual in the Soddy Daisy community, and he will be mourned by many. Godspeed Brother.

Melissa Smith is being held at the Sevier County Jail, according to police. Smith was booked into the jail at 1 a.m. on February 2. She was charged with first-degree murder and carrying a weapon while under the influence, according to online jail records.

She is being held in $1 million bail and has a March 2 court date scheduled on the weapon charge and a March 20 court date on the murder charge. It is not clear if she has appeared before a judge already.

Smith could not be reached for comment by Heavy and it is not known if she has hired an attorney who could speak on her behalf.

The Sevierville Police Department said in a statement, The investigation is ongoing and no additional information is available at this time.

READ NEXT: Recent College Grad Shot Dead While Driving with Boyfriend

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Dawn of the Customized Cure – Clinical OMICs News

Posted: February 7, 2020 at 2:41 pm

Personalized medicine has taken a big step forward with the launch of non-profit n-Lorem Foundation, which will create patient-tailored antisense oligonucleotide (ASO) therapeutics for people with rare diseases at no cost to the patients. This comes at the same time as custom gene therapies for rare disease patients are being developed, including some combined with CRISPR. As a result, more peopleeven those with ultra-rare diseasescould finally have access to treatments.

The process of developing these treatments is still burdensome and expensive. Only a few patients will benefit at first. But this concept has only been a dream until now, with most of these patients being completely shut out of the typical drug development process. Whats more, the scientists and sponsors pioneering these approaches are hoping to create blueprints for the treatment of ultra-rare diseases in general.

One of the goals is to create a replicable protocol, said Simon Frost, the father of Annabel Frost, a child who suffers from the ultra-rare disease alternating hemiplegia of childhood (AHC). We want to do it for our disease, and then take that process and give it to more patients across many more diseases. Frost, who is CEO of Tiber Capital Group, has been in discussions with multiple labs and investigating several approaches, including ASOs, gene editing, and gene therapy.

The blueprint for the ASO-based approach was a made-to-order treatment for a child with Battens disease, a rare neurodegenerative disorder. In 2018, Timothy Yu, a doctor at Boston Childrens Hospital, sequenced the genome in then six-year-old Mila to diagnose the condition. It turned out Mila had a retrotransposon which had inserted into her CLN7 gene. That aberration was blocking normal protein production by that gene.

Yus team then created a tailor-made ASO, which they called milasen, to mask the mutation in Milas genome, as detailed last year in the New England Journal of Medicine. It took about one year from sequencing to delivery of the therapy. Then, nine months after her treatment began, Milas doctors reported being hopeful about her prognosis, although they noted that she may already have experienced substantial effects from the disease. Hundreds of people, including parents and researchers, have since reached out to Yu to try and have this process replicated. Yus lab is reportedly developing several more personalized oligos, including ones for a rare form of epilepsy and ataxia-telangiectasia, which is a neurological disease.

Addressing the challenges

The demand for more custom ASOs is intense. But there are many issues standing in the way of such therapies.

ASOs are at the point where the investment in the technology has paid off commercially, said Art Krieg, an expert in oligonucleotide therapeutics as well as founder and chief scientific officer of Checkmate Pharmaceuticals. And now Tim Yu has shown the process for making customized ASOs. The questions is whether you can standardize that and could companies find it profitable to develop those therapies. Further, ASOs only block mutations and need to be given for life.

n-Lorem is funded with $1.5 million from Ionis (formerly Isis) Pharmaceuticals, another $1.5 million from Ioniss founder and former CEO Stanley Crooke and his wife Rosanne Crooke (a researcher at Ionis), $1 million from Biogen, and additional funds from other donors. Crooke started Ionis in 1989, as a pioneer in RNA-targeted therapeutics. Today, the company has three drugs on the market and more than 30 in development for a wide range of conditions. Biogen is partnered with Ionis on several of these.

Biogen declined to comment for this article, but sent this statement: Antisense oligonucleotides have been a game changer in the treatment of spinal muscular atrophy (SMA) and we believe they could hold promise in tackling other diseases. So, we are pleased to help support the establishment of n-Lorem Foundation and their mission to provide advanced, experimental RNA-targeted medicines free of charge to patients with ultra-rare diseases.

I knew we could do this and I knew there was a need, said Crooke, who started working on n-Lorem two years ago. But he also realized it was going to be challenging. The patients need a full genomic workup, and you need an investigator who can submit the IND and oversee it, he said. One major development that convinced Crooke the concept was feasible was the 2014 establishment of the Undiagnosed Diseases Network (UDN), a research study funded by the National Institutes of Health Common Fund. The UDN comprises clinical and research experts from across the U.S. who work to solve medical mysteries. As of 2019, 12 UDN clinical sites were open.

While UDN will be a key source of qualified patients, Crooke says n-Lorem will not be restricted to those. We announced the launch last week, and we already have six proposals for patients to treat. But patients need a confirmed genetic diagnosis and treating physicians. Then they must submit a proposal to treat to n-Lorems Access to Treatment Committee.

Another critical issue is the FDAs response. Crooke said he has already approached regulators and they are supportive. But n-of-1 trials like these raise special issues. In an editorial that accompanied the Yu teams report in NEJM, FDA regulators point out the many challenges to evaluating n-of-1 drugs what are the differences between treating one, ten, or thousands of patients? they asked.

But they also acknowledge that the field is moving ahead rapidly. Academic clinicianinvestigators now have the capacity to rapidly uncover specific mutations and pinpoint the putative mechanisms leading to certain rare disease phenotypes. Various ASOs or other compounds can be produced by third parties, and investigators can evaluate them using in vitro assays or animal models, the regulators wrote. FDA is holding a workshop in March on individualized therapies to try and advance thinking around this topic.

Ioniss long experience with ASOs should help in this regard. There are several generations, or classes, of ASOs that the company has developed over the last 30 years. Many years ago I began putting together integrative safety databases about the different classes of ASOs we have developed, Crooke says. Each class has generally similar properties, but they also have important differences such has ligands that work in different organs. Ionis has published on these databases and the properties they reveal, as well as providing the FDA access to the databases. That doesnt mean, however, that researchers will be able to predict all the effects of any ASO in any patient.

Finally, there is the question of cost, which is a particular boondoggle for rare diseases. We know this is feasible but we want to reduce the costs as far as we can, Crooke says. n-Lorem and Biogen are both already working on processes to further cut costs, But we will need to raise even more money to help more patients, he added. Patients shouldnt have to be on the internet raising funds for this.

While hes aware of the challenges, Crooke said hes feeling optimistic. Ive been overwhelmingly impressed with the commitment and advice weve gotten from physicians, experts on antisense and clinical trials,and others. He also hopes more modalities, besides ASOs will be able to work with n-Lorem and start similar endeavors. Im hopeful a gene therapy company can join us or do the same thing, he noted.

Gene therapy too

While there is nothing equal to n-Lorem yet, other researchers are already pursuing customized gene therapies, even for patients who have mutations that are very rare or that are not correctable with standardized gene therapy.

Monkol Lek, for example, is a geneticist at Yale who has been working on a gene therapy for a single patient with an ultra-rare mutation in a muscular dystrophy gene. There are more than 30 types of muscular dystrophy, and some are caused by mutations that affect different genes or varying sections within those genes. Lek himself has limb-girdle muscular dystrophy (MD). When he was first diagnosed, he remembers hearing over and over again that there were no treatments for his condition.

That was enough to inspire Lek to leave a career in IT while in his 20s and obtain degrees in physiology, bioinformatics, and genetics. Soon after he arrived at Yale in 2018, Lek met Rich Horgan, founder of the non-profit Cure Rare Disease, and whose younger brother Terry has a type of MD. Lek analyzed Terrys genomic data, and found he is missing the dystrophin genes promoter region, which needs to be activated in order for that protein to be made. Terry is also missing part of exon 1, which is also necessary to generate the production of dystrophin.

While they originally considered using ASOs, Rich Horgan and Lek realized that wasnt feasible because rather than needing to turn off a gene, they needed to turn on a gene, or at least its promoter.

One twist in this particular case is that people have two alternative versions, or isoforms, of this promoter and exon 1one set in muscle cells and another in brain cells. With that in mind, Lek is using a modified version of CRISPR called no-cut CRISPR to introduce a transcription activator attached to the Cas9 enzyme to turn on the brain-specific set, and thus make up for the deficit in muscle. He uses an AAV and CRISPR activation construct as well as guide RNA to direct the CRISPR to the right spot in the DNA.

Lek has already tested his putative therapy on Terrys cells and successfully corrected the mutated gene in the lab. Next, the treatment will be tested in mice. However, Lek is also exploring the possibility of an n-of-1 clinical trial in which the therapy would only be tested in Terry or anyone with his specific mutation.

Rich Horgans Cure Rare Disease group is now leading new projects for two boys with different forms of Duchenne MD as well as a patient with the limb girdle form of the disease.

Frost, meanwhile, is still investigating the best options for treating his daughter Annabel. His family has spent $250,000 so far and he expects it will cost another $250,000 to $500,000 to reach proof of concept. Annabels mutation is in ATP1A3, a gene that is associated with at least 12 different rare diseases (See table). However, Annabels specific mutation is very rare. Were not sure yet how many of these other conditions would be treated by the same transgene, but it could be a large proportion, Frost said.

Krieg noted that we are not yet at the point where any for profit company will want to develop n-of-1 therapies. It doesnt cost that much to manufacture DNA, and its a fully automated process, he said. It has taken billions of dollars already to get the technology this far and develop applications for some more common diseases. But the overall cost of lifetime treatment is still prohibitive. Right now, I dont know why any company would want to do this, he added. But there will come a time when there are the right incentives and someone will try it.

For families such as Annabel Frosts, these developments are still encouraging, and give them hope that they can help shape the future of the new field of n-of-1 therapeutics. This also supports the idea that more children should undergo whole genome sequencing as soon after birth as possible. With many rare diseases, the damage is compounded the longer the child is untreated. Further, greater understanding of how the full range of possible mutations in any gene impact health, and how that can be treated, will press the field forward.

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Want To Be Disease-Free? This One Lifestyle Change Is All You Need! – Doctor NDTV

Posted: February 7, 2020 at 2:41 pm

Your thoughts make up your feelings. So, the amount of time you spend on a thought, be it happy or unhappy, is going to affect your feeling and mood. Feeding unhappy thoughts can make you unhappy. Unhappiness causes discomfort, which in the long run leads to diseases.

Staying happy is important to stay stress-free and disease-free

Some of the most common diseases like obesity, diabetes, PCOD and thyroid are related to poor lifestyle. A poor lifestyle is a combination of poor eating habits, lack of exercise, smoking, drinking alcohol regularly and irresponsibly, chronic stress, anxiety and lack of sleep. According to lifestyle coach Luke Coutinho, one thing which is common in people with lifestyle is unhappiness. Unhappiness, he says, is the major cause of most lifestyle-related diseases. It is important to understand that happiness is something which you cannot seek from outside or from someone else and should come from within.

As part of a live session on Facebook, Luke says that unhappiness causes discomfort. Too much of discomfort ultimately leads to development of a disease. "Unhappiness comes from unhappy thoughts. Your thoughts are everything," says Luke.

Do not unnecessarily feed unhappy thoughts as they can make you feel stressed and uncomfortablePhoto Credit: iStock

The idea is to understand that even one happy unhappy or negative thought can make you feel uncomfortable and stressed, and ultimately affect your health negatively.

Also read:Can Stress And Anxiety Cause Hair Loss? Know Types And Ways To Hair Fall

Your thoughts make up your feelings. So, the amount of time you spend on a thought, be it happy or unhappy, is going to affect your feeling and mood.

"You are going to experience both happy and unhappy, jealous or angry, positive or negative thoughts. What matters is how much attention you pay to each of these thoughts," Luke explains.

Happiness exists independently of circumstances and conditions. As mentioned above, it comes from within and is not dependent on anything or anyone. So, a boss' feedback, an increment letter or a perfect life partner are not factors that are going to make you happy.

Happiness cannot have conditions. Conditioning it with a certain amount of money or any other kind of gain is going to make you miserable and prone to diseases.

Do not seek happiness from something or someone else. Happiness comes from withinPhoto Credit: iStock

Also read:5 Worst Inflammation Causing Foods: Avoid Them To Prevent Diseases

Thus, it is important to decide that you need to be happy by thinking of the things that are going well for you at the moment. It is important for both your physical and mental health.

Pay less attention to unhappy thoughts. Stop feeding them as unhappy thoughts lead to unhappy feelings. Do not expect your happiness from someone else. It is your responsibility and once you decide it, there is nothing that can stop you from being happy, stress-free and disease-free.

Also read:5 Lifestyle Habits That Can Help You Live Longer, Be Disease-Free

(Luke Coutinho, Holistic Lifestyle Coach - Integrative Medicine)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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World Cancer Day 2020: 6 Cancer-Causing Foods And Drinks That You Need To Quit Now – NDTV News

Posted: February 7, 2020 at 2:41 pm

World Cancer Day: Processed food, junk food and aerated drinks can increase risk of cancer

World Cancer Day is observed on February 4. Every year, the Union for International Cancer Control organises Cancer Day to raise awareness about cancer, tips for prevention and how to ease suffering for cancer patients. The theme for World Cancer 2020 is "I am and I will". World Cancer Day 2020 theme acknowledges that everyone has the capacity to act in the face of cancer. Cancer is referred to uncontrolled growth of abnormal cells in the body. Cancer develops when the body's normal control mechanism stops working. Old cells are unable to diet and they instead grow out of control, forming new and abnormal cells.

A poor lifestyle with lack of exercise, poor diet and sedentary lifestyle is one of the many reasons why more and more people are getting cancer, believes lifestyle coach Luke Coutinho. Following is a list of cancer-causing foods and drinks that you must avoid:

Research has found that the more alcohol you drink, the higher is your risk of developing cancer. Excessive alcohol intake puts you at risk of liver, breast, oesophageal and colorectal cancer. When the body metabolises alcohol, it produces acetaldehyde, which is a chemical compound that may damage DNA, leading to cancer. This World Cancer Day, pledge to limit your alcohol intake and try to get off it in full entirety. Note that no amount of alcohol (not even two drinks in a day) is healthy for your body.

Reduce your alcohol intake in order to prevent cancerPhoto Credit: iStock

Also read:Is Alcohol Consumption Linked To Heart Disease: Let's Find Out

Processed food is one of the unhealthiest foods you can include in your diet. Processed and packaged food are devoid of any nutrition. They contain high amounts of unhealthy carbs, leading to weight gain and obesity-which is a known risk factor for cancer. Processed meat like sausage, bacon, hot dogs, pepperoni and salami are even more harmful. They are made with chemical preservatives, salting and smoking to increase their shelf life. Studies have found that processed meat can increase risk of colorectal cancer. Celeb nutritionist Rujuta Diwekar says that you should avoid everything that comes in a packet, and this includes everything from soya and kale chips to tomato ketchup, condiments and dips, etc.

Switch to fresh fruits, vegetables, homemade spices and food instead of processed food to reduce your risk of cancer.

Sugary drinks like diet soda and aerated drinks are the ones that cause weight gain and provide you with zero nutrition. These drinks contain artificial sweeteners that have been found to increase risk of cancer. Instead of aerated drinks, have lemon water, coconut water, sugarcane juice or unsweetened fresh fruit juice to reduce your risk of developing cancer.

Avoid aerated drinks to reduce your risk of cancerPhoto Credit: iStock

Also read:Nmami Agarwal Decodes Health Risks Associated With Sugary Drinks: You Will Be Surprised To Know These

No matter how quick and convenient microwave popcorn are, they are doing more harm to your health than you can imagine. Microwave popcorn bag linings contain perfluorooctanoic acid (PFOA), which can be carcinogenic. The better alternative is to get fresh corn and prepare popcorn at home. It might take a few extra minutes but can reduce your risk of developing cancer.

Smoking is a lifestyle habit and is cancerous, as you all know. The top most cause of lung cancer in the world is smoking. Apart from cancer, smoking can cause coughing, breathing problems, asthma and a lot of other ailments that can affect your day-to-day functioning and reduce your lifespan. Take professional help if you are unable to quit smoking. Start with reducing one cigarette at a time. There is no tomorrow for quitting smoking.

Hydrogenated oil are commonly used for preserving processed foods and increasing their shelf life. Hydrogenated oils have the capability to alter structure and flexibility of cell membranes throughout the body, increasing your risk of cancer. Avoid foods with trans fats and saturated fats in order to reduce your cancer risk.

Along with avoiding these foods and drinks, you also need to be physically active and exercise regularly. Regular exercise can reduce your risk of cancer, high blood pressure, high cholesterol, heart disease, obesity and weight gain. This World Cancer Day, make more and more people aware of these cancerous foods, drinks and lifestyle habits and do your part in making the world cancer-free.

Also read:World Cancer Day: Follow These Expert Guidelines To Reduce The Risk Of Breast Cancer

(Luke Coutinho, Holistic Lifestyle Coach - Integrative Medicine)

(Rujuta Diwekar is a nutritionist based in Mumbai)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Nano Medicine: Meaning, Advantages and Disadvantages

Posted: February 6, 2020 at 6:45 am

In this article we will discuss about Nano Medicine:- 1. Meaning of Nano Medicine 2. Advantages of Nano Medicine 3. Disadvantages.

The application of nanotechnology in medicine is often referred to as Nano medicine. Nano medicine is the preservation and improvement of human health using molecular tools and molecular knowledge of the human body. It covers areas such as nanoparticle drug delivery and possible future applications of molecular nanotechnology (MNT) and Nano-vaccinology.

The human body is comprised of molecules. Hence, the availability of molecular nanotechnology will permit dramatic progress in human medical services. More than just an extension of molecular medicine, Nano medicine will help us understand how the biological machinery inside living cells operates at the Nano scale so that it can be employed in molecular machine systems to address complicated medical conditions such as cancer, AIDS, ageing and thereby bring about significant improvement and extension of natural human biological structure and function at the molecular scale.

Nano medical approaches to drug delivery centre on developing Nano scale particles or molecules to improve drug bioavailability that refers to the presence of drug molecules in the body part where they are actually needed and will probably do the most good. It is all about targeting the molecules and delivering drugs with cell precision.

The use of Nano robots in medicine would totally change the world of medicine once it is realized. For instance, by introducing these Nano robots into the body damages and infections can be detected and repaired. In short it holds that capability to change the traditional approach of treating diseases and naturally occurring conditions in the human beings.

1. Advanced therapies with reduced degree of invasiveness.

2. Reduced negative effects of drugs and surgical procedures.

3. Faster, smaller and highly sensitive diagnostic tools.

4. Cost effectiveness of medicines and disease management procedures as a whole.

5. Unsolved medical problems such as cancer, benefiting from the Nano medical approach.

6. Reduced mortality and morbidity rates and increased longevity in return.

1. Lack of proper knowledge about the effect of nanoparticles on biochemical pathways and processes of human body.

2. Scientists are primarily concerned about the toxicity, characterization and exposure pathways associated with Nano medicine that might pose a serious threat to the human beings and environment.

3. The societys ethical use of Nano medicine beyond the concerned safety issues, poses a serious question to the researchers.

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The Future Of Nano Medicine

Posted: February 6, 2020 at 6:45 am

Nanomedicine, refers to highly specific medical intervention at the molecular level for curing disease or repairing damaged tissues. Though in its infancy, could we be looking at the future of medicine? Early clinical trials certainly look promising.How Nanomedicine Works

- Nanomedicine works by injecting nanoparticles into the body- Can be used to:- Deliver medicine- Find and treat disease- Repair damaged cells

One human hair is approximately 80,000 nanometers wideApplications of Nanomedicine

- Drug Delivery- Using nanotechnology to deliver medicine, diabetic rats kept stable blood sugar levels for 10 days after injection- Cancer Diagnosis and Treatment- Using microRNA from a patient's blood plasma and nanotechnology:- Medical professionals can determine if lung cancer is present- Begin treatment the same day- Using Nano-Therm therapy to overheat brain cancer cells helps to destroy them- In clinical trials, those with recurrent glioblastoma survived a median of 13 months- More than double the survival rate of those not receiving Nano-Therm therapyNanotechnology is already commonly used in sunscreen and to make tennis balls more bouncy

- Flu Testing- Today's flu tests are:- Time consuming- Inaccurate- Nanomedicine gold flu testing provides:- Instant results- Immediate treatment cycle to avoid spreading to others- commercial nanotech testing no more than 5 years away- Cell Feedback- Nanomedicine can be used to test cell's response to drugs offering new drug testing methods- Provides instant feedback to how cells respond to medicine- Can save years and millions of dollars on testing and clinical trials- Can improve current medications

In a 1956, Arthur C. Clarke first envisioned the concept of nanotechnology in a short story, The Next TenantsAdvantages of Nanomedicine

- Faster diagnosis of many ailments- More precise treatments of conditions such as cancer- Repair tissue deep within the body- Target only diseased organs, lessening the need for drugsSources

- https://commonfund.nih.gov/nanomedicine/overview.aspx- http://www.understandingnano.com/medicine.html- http://pubs.acs.org/doi/abs/10.1021/nn400630x- http://www.nature.com/nnano/journal/v6/n10/full/nnano.2011.147.html- http://www.dana.org/news/features/detail_bw.aspx?id=35592- http://pubs.rsc.org/en/Content/ArticleLanding/2011/AN/C1AN15303J- http://onlinelibrary.wiley.com/doi/10.1002/smll.201001642/abstract- http://www.clinam.org/benefits.html

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Is the Lieber Arrest Linked to Military Brain Research and China? – Bryen’s Blog

Posted: February 6, 2020 at 6:45 am

Originally Published in Asia Times in different format

by Stephen Bryen

Harvard scientist Charles Lieber was arrested last week and charged with one count of giving materially false, fictitious and fraudulent statements to the U.S. government and the FBI.

What marks the case as unusual is that a prestigious specialist at one of Americas top universities was criminally charged for what appears to be a less-than-candid response to questions about government contracts.Typically, paperwork problems would be dealt with administratively, as the US would be reluctant to lose the services of a distinguished scientist.Instead, Liebers case is lumped together with two China-related cases of spying and smuggling.

[Also charged were two Chinese citizens, one allegedly secretly a member of the Peoples Liberation Army (PLA), charged with visa fraud, making false statements, acting as a foreign agent in the United States, and with conspiracy; and a second person charged with smuggling biological material to China.]

Lieber is a specialist in nanotechnologies, a field that is getting billions of investment dollars from the United States government, including the Defense Department (DOD), and from the private sector.The U.S. sees itself in a tense competition with China in this field for both commercial and national security reasons.

This competition, and specificallythe potential military applications, are creating considerable anxiety in the U.S. military as China becomes more deeply involved in investment and the possible theft of Americanknow-howand technology. Criminal, rather than administrative, charges against Lieber suggest U.S. authorities were deeply alarmed by his activities in China and were aimed at ending his professional association with that country.

The specific specialty developed by Lieber and of possible strategic interest to DOD is mesh technology at nano-scale.A nano-scale mesh device offers considerable opportunitiesover rigid electrodes implanted in the human brain. Lieber, wrote one medical professional, has made a huge difference with ultra-flexible mesh electronics, which promise to deliver what he calls precision electronic medicine. These hardly activate an immune response, but remain very close to the cells they are intended to spy on.

Lieber is one of the top scientists involved withElon Muskin a rather secretive startup company calledNeuralink. Musk has invested $100 million of his own money and raised another $58 million for Neuralink, which now has a staff of 90.The company isexploring brain machine interfaces, using what Musk calls flexible threads thathave the potential of transferring a higher volume of data, according to a White Paper credited to Musk & Neuralink. The abstract notes that the system could include as many as 3,072 electrodes per array distributed across 96 threads.The threads are 4 to 6 m in width, which makes them considerably thinner than a human hair. In addition to developing the threads, Neuralinks other big advance is a machine that automatically embeds them.

There are many applications of this futuristic technology including improved medical therapies for brain-related disorders and bridging connections between man and machines.

Why would this be of interest to the U.S. military or to China?

Robotics, artificial intelligence (AI), and nanotechnology are at the forefront of weapons-building programs, with China the main current competitor to the U.S. LTG Robert P. Ashley, Director of the Defense Intelligence Agency (DIA) addressed the subject before the Association of the US Army. He focused directly on China, warning that China is mergingartificial intelligence with humans using nanotechnology as the connectivebridge.DIA, he said, sees this as a major concern for the future of warfare.

Using nanotechnology to link the brain to machines and sensors, and AI to arbitrate the linkage, has roots that go back decades and involve the use of drugs and psychological techniques to manipulate the human brain.Horrid experiments were carried out by Nazi Germany on concentration camp inmates. Japan did the same through its infamous chemical and biological weapons operation called Unit 731, which conducted experiments on prisoners.The Nazis and Japanese shared information on the results.

At the end of WWII, underOperation Paperclip, the CIA and Defense Department brought Nazi scientists back to the United States, including many who were engaged in using concentrationcamp inmates as subjects. One, BG (Generalarzt)Walter Paul Emil Schreiber served in the Nazi Wehrmachtand the SS, where hewas involved in assessing results of human testing at Dachau. Once in the U.S., he worked at theAir Force School of Medicine atRandolph Air Force BaseinTexas. When his background was exposed by news reporters, the US Air Force slipped him and his family out of the country on a military plane to Argentina, where there were many other former Nazis operating including the killer-doctor Josef Mengele.

Meanwhile, the CIA continued experimenting with humans, using both psychological techniques and psychotropic drugs for another twenty-two years (1953-1975) when brain research activity was apparently discontinued after Congressional hearings by the Church Committee (formally theSenate SelectCommitteeto Study Governmental Operations with Respect to Intelligence Activities).

Have the man-machine interface, nano-technology, robotics, and AI taken the place of earlier experimentation with drugs for mind control? It is impossible to say, but it is clear the U.S. believes China is in pursuit of this technology for military use. Charles Liebers work with the Chinese, and his alleged failure to fully disclose the fact, certainly triggered the Defense Department and intelligence communitys concerns and more than likely they pushed the FBI and the Department of Justice to bring about Liebers indictment, using what appear to be numerous email and communications intercepts to build their case, many of which are in the unsealed indictment.

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VVUS Stock Jumps 70% on FDA Nod for New Formulation of Pancreaze – MicroSmallCap

Posted: February 6, 2020 at 6:45 am

When biotech or pharmaceutical companies win approvals from the United States Food and Drug Administration, the stock prices almost always go up, and that is what happened with VVUS stock this morning. VVUS is normally a thinly traded nano-cap stock, but this morning, the stock soared after it emerged that the FDA has granted the approval of VIVUS, Incs (NASDAQ:VVUS) new product.

The product in question is a new formulation of Pancreaze (pancrelipase), and there is a 36-month shelf life for it across the range of different dosages.

The approval granted by the FDA is actually a supplemental New Drug Application (sNDA), which is granted to products that are an improvement on an existing formulation. VIVUS got the sNDA approval for its improved formulation of Pancreaze (pancrelipase). The company collaborated with its manufacturing partner Nordmark Arzneimittel GmbH & Co. KG on this project.

>> Penny Stocks to Watch: Trillium Therapeutics and Callon Petroleum

This is a hugely significant development for the company, and the reaction from the market is not a surprise at all. VVUS stock soared by as much as 70% to $3.89 in morning trade as investors piled onto the stock, and it is likely that VVUS is going to be in sharp focus for the rest of the trading session.

The medicine in question is meant for treating exocrine pancreatic insufficiency (EPI) that is brought about by cystic fibrosis or other conditions. The Chief Executive Officer of the company, John Amos, stated that approval is an important milestone for the company and also for patients who suffer from EPI. He went on to state, It highlights our ability to derive additional value from our marketed products and allows patients to store PANCREAZE for longer periods of time, which may help to reduce their out-of-pocket expenses.

The developments today have been a landmark for VIVUS, and market watchers will, no doubt, be following VVUS stock closely over the coming weeks.

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