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2020 Emerging Scholars: Dr. Cathy Wong – Diverse: Issues in Higher Education

Posted: February 6, 2020 at 6:42 am

January 30, 2020 | :

As Dr. Cathy Wong tells it, she stumbled into her career in academia after she walked into a lab and saw how colorful the lasers were.

I thought this could be really fun, says Wong, who uses lasers to study how material interacts with light and solar cells. Her research, which uses physical chemistry to research material synthesis, has longstanding implications, including responding to the worlds energy crisis.

Dr. Cathy Wong

As an assistant professor in the Department of Chemistry and Biochemistry at the University of Oregon, Wong spends much of her time helping undergraduate juniors and seniors as well as graduate students develop passion for scientific research.

I kind of always knew I wanted teaching to be part of my work, says Wong, who earned her bachelors degree in biological chemistry from McMaster University in Toronto and her Ph.D. in 2011 from the University of Toronto. She later completed a postdoctoral degree from the University of California, Berkeley.

Having grown up in Toronto where ethnic differences are often celebrated, embracing diversity has been a hallmark of Wongs career. Unlike her hometown, the city of Eugene, where the University of Oregon is situated, is less racially diverse, meaning that Wong who hopes to come up for tenure in a little less than two years has made it her priority to help students develop a sense of belonging and connection to the university.

In the classroom, Wongs work largely focuses on helping design physical chemistry labs and teaching students how to build microscopes and write lab reports skills she says will prove useful in their future careers.

Though she works with science majors, she teaches a section of physical chemistry that requires heavy math skills that often create anxiety among her students.

Some are apprehensive, she says. I reassure them, you can do it even if it is complicated and overwhelming.

Clarity, Wong says, is essential to teaching in the sciences.

My philosophy of teaching and communication about science in general is not just to sound smart but to be as clear as possible, even if that means simplifying sometimes, she says. This way you bring everyone along and everyone can be engaged.

In this regard, Wong has been lauded for her teaching and research. Last year, she was named the recipient of a Career Award by the National Science Foundation. These awards are given to support early career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization.

Those who know her say that Wong has been a leader in working tirelessly to increase the diversity of the graduate student population within a state that is itself not racially diverse.

Wong currently serves as the faculty sponsor for a student group, Community for Minorities in STEM (CMiS), that aims to retain students in racial minority groups. This group organizes social and professional development activities that aim to foster community among underrepresented graduate students, battle imposter syndrome and improve retention rates.

Wong also founded a program called Peer Recruitment In Science & Math (PRISM) that enables underrepresented graduate students to give research seminars at colleges that serve a large percentage of minority students.

By giving the undergraduate students an example of a near-peer who has succeeded in graduate school, the program aims to inspire more underrepresented minority undergraduates to pursue graduate studies, says Dr. Naomi Ginsberg, an associate professor of chemistry at the UC Berkeley and one of Wongs career mentors. The program has been highly effective in increasing the number of applicants to the graduate program at UO from underrepresented groups.

Wong says that she has enjoyed her time in the classroom and that her understanding of the academy has evolved over time.

When I started out, I had no idea how universities really worked, she says with a laugh. Now that Ive been here, I see that there are great opportunities to have a voice and help to effect change.

Dr. Cathy Wong

Title: Assistant Professor in the Department of Chemistry and Biochemistry at the University of Oregon

Education: Bachelors degree, McMaster University, Biological Chemistry; Ph.D., University of Toronto, Physical Chemistry

Age: 38

Career mentors: Dr. Greg Scholes, University of Toronto; Dr. Naomi Ginsberg, UC Berkeley

Words of wisdom/advice for new faculty members: Youre going to be asked to do a lot of things and its important to say no to some and reserve the time for those things that you really care about and that matters most to you and your department. Also, seek out career mentors who can help guide you along the way.

This article appeared in the January 23, 2020 edition of Diverse.

This is one in a series of profiles about this years 2020 Emerging Scholars. Read about all of them here.

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Genuine HCG Regimen – Along the Boards

Posted: February 6, 2020 at 6:41 am

HCG (Human Chorionic Gonadotropin) has become a significant questionable sign mark because, among other dietary plans, it has some rigorous nutritional principles which have both advantages as well as the side effects. According to many experts, HCG combines a deficient daily calorie intake with ingestion of the hormone genuine HCG as an effective way to lose weight. According to some other experts, the HCG diet program has become a significant question mark is it safe to continue the HCG diet plan? Sports scientist for Renaissance Periodization like MIKE ISRAETEL SAYS The HCG diet is almost the quintessential fad diet. Another interesting fact about this peculiar diet plan is that no clinical studies suggesting that this dietary plan, namely HCG, helps in weight loss. However, this parlance might lookalike a vague statement, especially for the HCG diet disciples.

The peculiarity of this dietary routine lies in its two chief components. The first component is limiting us from 500 to 800 calories intake per day. The HCG diet program immensely emphasizes the usage of protein from lean meats, poultry, and fish. However, the other component is injecting (getting an injection of) HCG, typically into your thigh, or taking it as an oral drop either in spray form as a pellet or tablet.

HCG triumph is one of the very well-known and recognized brands in the world. It has numerous positive reviews from its customers as well as the best results. People who have used genuine HCG triumph much time are immensely satisfied with the supreme quality of this product.

HCG plus drops are the next product in this list. They provide the best possible genuine HCG drops, and the customers could not stop trust them. However, some customers became worried while using this product. In the end, it all ended well for them due to the high ratio of positive reviews from other customers.

The real HCG hormone drop is undoubtedly a very trusted and highly recommended product available in the market. That is a well-known brand, especially in terms of high quality.

Under the strict Genuine HCG dietary plan, the disciples of this diet are allowed to consume a variety of vegetables, including cauliflower, celery, spinach, fennel, radishes, shallots, asparagus, tomatoes and broccoli, mixed greens and beet greens. One low-calorie vegetable for both lunch and dinner is another strict diet under this plan. The natural HCG diet is not easy, and it raises multiple questions like this one is the HCG diet praiseworthy or not? There are a variety of HCG approved fruits that can be taken under this plan, namely lemons, apple, oranges, raspberries, blueberries, grapefruits, and strawberries.

The genuine HCG is not that easy to follow; it has a variety of food restrictions. It would help if you were peculiar abstinent, especially of fat-free protein. Most of every calorie sources primarily come from protein. The lunch and dinner consisted of low-calorie protein sources that help energize the body. The genuine HCG has a strict schedule dietary plan which compels its followers to eat as low as 3.5 ounces(approx) of lean, fat-free protein at each meal. Seasonings that are taken regularly as a backup diet source such as parsley, pepper, sweet basil, parsley, and mustard powder are acceptable. Oil (even healthy cooking oils), butter, kromesky, cheese, and other healthy cooking oils are not allowed under the diet.

According to the Federal government from 1600 to 2400 calories for adult women and 2000 to 3000 calories for adult men. According to the dietitians and other food regimen experts, eating only 500 to 800 calories a day could be massively risky for your health as it lowers down the energy level both the adolescent men and women. It deprives the body of the many vital compulsory vitamins which are immensely important for a healthy human body. One of the most challenging reasons why the HCG has been considered a risky dietary routine is the lack of calorie intake. As discussed earlier in the article, an adult man requires about 2000 to 3000 calories a day, and the calorie intake for a healthy woman should be 1600 to 2400 calories a day, which is highly contrary to the ratio available under this diet regimen. Other protein sources that are allowed under this strict diet regimen are scallops, white fishes, buffalo, shrimps, lobsters, extra-lean beef, and chicken. Fattier fish choices like the herring, tuna, and salmon are off-limits. For more information about the HCG diet.

Dr. David Friedman says in conjunction with a meager and feeble calorie count, the genuine HCG regimen also suggests us to take daily drops (injections of the pregnancy hormone hCG, or human chorionic gonadotropin. During the imprimis stages of the first trimester, it immensely helps with the secretion of progesterone. This hormone is made in cells and formed up in the placenta, which nourishes the egg after its been fertilized and becomes attached to the uterine wall.

Some experts and dieticians highly recommend to consult the expert dietician before following the genuine HCG dietary plan because, according to many food experts, the low-calorie intake could drastically harm your health. Under this nutritional plan, you can take tea or coffee with no sugar. However, calorie-free sweeteners are allowed. The market is filled up with numerous standardized HCG Real HCG Drops, and its suppliers are lingering in the vicinity. Still, it would be best if you took care of yourself before practicing any diet plan for your healths betterment and safety. Lastly, it can be said that The natural HCG diet is a rigorous routine that can be followed for the sake of abstinence, but you have to scrutinize your health issues to maintain your health.

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Global Radiation Therapy Market to Reach US$ 8.6 bn by 2026, Product Approvals to Drive Growth: Transparency Market Research – PRNewswire

Posted: February 4, 2020 at 7:49 pm

ALBANY, New York, Feb. 4, 2020 /PRNewswire/ -- Amid technological advancement, and notable research and development activities, the global radiation therapy marketis set to chart a sturdy growth curve, owing to a steady growth rate of 5.2% from 2018 to 2026. As per Transparency Market Research (TMR), the growth is attributable to surge in product approvals, increase in expenditure on healthcare, high incidence of cancer, and a growing preference for non-invasive treatment procedures.

TMR states that, "From bench to clinic, there is a wave of therapeutic and diagnostic technologies, paving way for higher growth in oncology. And, this will aid radiation therapy witness better times to come. Over the forecast period external beam radiation therapy will dominate the market landscape."

Key Findings of the Radiation Therapy Market Study

Explore 183 pages of top-notch research, incisive insights, and detailed country-level projections. Gain business intelligence on radiation therapy market by Type - External Beam Radiation Therapy (Conformal Radiation Therapy, Proton Beam Therapy, Image Guided Radiation Therapy, Stereotactic Radiation Therapy), Internal Radiation Therapy (Brachytherapy, Systemic Radiation Therapy); End user - Hospitals, Specialty Clinics. https://www.transparencymarketresearch.com/sample/sample.php?flag=S&rep_id=36080

Radiation Therapy Market: Key Driving Factors

The market report, based on extensive research, by Transparency Market Research, is leading to growth in the landscape. And, a wave of innovation is keeping the statistics buoyant over the period. Some of the factors that will sustain growth over the forecast period in the global radiation therapy market include the following:

View Detailed Table of Contents athttps://www.transparencymarketresearch.com/report-toc/36080

Key Impediments for Radiation Therapy Market Players

While the overall outlook of the global radiation therapy market is positive, TMR speaks of certain restraints that will hamper growth to some extent. According to the study, the key restraints impeding market growth include,

Radiation Therapy Market: Region-wise Analysis

Analyze radiation therapy market growth in 30+ countries including US, Canada, Germany, United Kingdom, France, Italy, Russia, Poland, Benelux, Nordic, China, Japan, India, and South Korea. Request a sampleof the study,

Competition Landscape

Strategic alliances and a keen focus on technological advancement is the key to growth for players operating in the global radiation therapy market over the forecast period. One of the most notable agreement that took place in the recent past November 2018 is that between Chengdu Xingcheng and Mevion. The aim behind the move is to lead center for proton therapy in China's sub-provincial city Chengdu.

Besides, players are focused on product development and launch. For instance, in the year 2018, ProBeam 360 a system of single room proton therapy - was launched by Varian Medical Systems. In the same year Hitachi Ltd. received approval for commercialization of RGPT.

Key players include Varian Medical Systems, Inc. (US), Elekta (Sweden), Accuray Incorporated (US), Ion Beam Applications SA (Belgium), ViewRay, Inc. (US), IsoRay Medical, Inc. (US), Hitachi Ltd. (Japan), Panacea Medical Technologies Pvt. Ltd. (India), Provision Healthcare (US), and Mevion Medical Systems, Inc. (US)

Transparency Market Research has segmented the radiation therapy market report based on type, end-use and region.

By Type:

External beam Radiation Therapy

Internal Radiation Therapy

By End user:

Explore Transparency Market Research's award-winning coverage of the global Pharmaceutical industry:

External Beam Radiation Therapy Market- External beam radiation therapy is the most common type of radiation therapy used in cancer treatments around the world. During the therapy, high-intensity radiation beams form a linear accelerator are focused on the tumor. Major drivers of the global external beam radiation therapy market are increase in patient population, new product approvals, technological advancements, favorable reimbursement policies, and rise in health care expenditure in developing economies such as India and others.

Proton Therapy Market- Rise in prevalence of cancer patients, growing awareness among people, improvement in insurance coverage for proton therapy, increase in consumption of tobacco, and surge in demand for proton therapy are factors driving the global proton therapy market. Tobacco use is associated with increased risk of several cancers including lung, oral cavity, pharynx, bladder, esophagus, kidney, liver, stomach, larynx, pancreas, bowel, cervix, leukemia, and ovarian.

Cancer Biomarkers Market- The global cancer biomarkers market is expected to exhibit a splendid CAGR of 11.8% during the forecast period from 2017 to 2025. In this timeframe, the market is anticipated to gain revenue worth US$27.63 bn by the end of 2025. Increasing incidences of various types of cancers all over the globe has caused a rise in the need for cancer biomarkers, thereby providing a healthy impetus to the associated market.

Cancer Cachexia Market- The cancer cachexia market stood at US$1.63 bn and is projected to garner a CAGR of 4.90% from 2017 to 2025. By the end of this assessment period, opportunities in the market will climb to US$2.51 bn. The growth of the global cancer cachexia market is fueled by vast research on using multiple agents for treating metabolic abnormalities in cachexia. Development of these multiple pharmacologic agents will further gather steam on the back of regulatory landscape.

Stem Cells Market- the global market for stem cells is projected to reach a value of US$270.5 bn by the end of 2025. The market is likely to exhibit a strong 13.80% CAGR between 2017 and 2025. The rapid development of the infrastructure that is required for the stem cell banking and processing, especially in developing economies is predicted to encourage the growth of the global stem cells market in the coming years.

Gain access to Market Ngage, an AI-powered, real-time business intelligence that goes beyond the archaic research solutions to solve the complex strategy challenges that organizations face today. With over 15,000+ global and country-wise reports across 50,000+ application areas, Market Ngage is your tool for research on-the-go. From tracking new investment avenues to keeping a track of your competitor's moves, Market Ngage provides you with all the essential information to up your strategic game. Power your business with Market Ngage's actionable insights and remove the guesswork in making colossal decisions.

About Us

Transparency Market Research is a next-generation market intelligence provider, offering fact-based solutions to business leaders, consultants, and strategy professionals.

Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. The detailed and proprietary statistical models used by our analysts offer insights for making right decision in the shortest span of time. For organizations that require specific but comprehensive information we offer customized solutions through adhoc reports. These requests are delivered with the perfect combination of right sense of fact-oriented problem solving methodologies and leveraging existing data repositories.

TMR believes that unison of solutions for clients-specific problems with right methodology of research is the key tohelp enterprises reach right decision.

ContactTransparency Market ResearchState Tower,90 State Street,Suite 700,Albany NY - 12207United StatesUSA - Canada Toll Free: 866-552-3453Email: sales@transparencymarketresearch.comWebsite: http://www.transparencymarketresearch.com

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Stem Cell Pain Relief No Surgery Regenerative Therapy Webinar Released – Newswire

Posted: February 4, 2020 at 7:49 pm

Gilbert, Arizona based alternative medicine specialist Dr. Farid Rooh launched a new webinar on stem cell therapy, exosome injections, and other regenerative medicine therapies for chronic pain.

(Newswire.net -- February 3, 2020) -- Gilbert, AZ -- Gilbert, Arizona based alternative medicine specialist Dr. Farid Rooh launched a new webinar on stem cell therapy, exosome injections, and other regenerative medicine therapies for chronic pain.

Dr. Farid Rooh-Parvar DPSc, BCIM of Wellness 1st Integrative Medical Center in Gilbert, Arizona, announced a new webinar on the most effective regenerative medicine therapies for chronic and acute pain, arthritis, sciatica and other conditions.

More details can be found at http://bit.ly/2L8DNxY.

The newly released webinar aims to answer a series of important questions related to the most effective ways to address pain resulting form a variety of musculoskeletal conditions.

Dr. Rooh discusses the numerous applications of research-based regenerative medicine on countless patients who have seen important improvements in terms of pain relief, improved function and mobility.

The new webinar includes a detailed look at therapeutic approaches including stem cell therapy, exosome injections, amniotic tissue, adipose tissue and bone marrow therapies and more.

The focus is on helping viewers get a basic understanding on how the latest innovations in alternative, holistic and regenerative medicine can help patients suffering from a diverse range of health issues.

The webinar provides essential insights into the applications of regenerative medicine for the treatment and management of neck, back, shoulder and join pain, sciatica, arthritis, tennis elbow, loss of feeling in feet and other conditions.

All approaches are based on identifying and addressing the root cause of the patients health issues, rather than simply alleviating the symptoms.

With the latest announcement, Dr. Rooh continues to expand his range of high-quality alternative and regenerative medicine resources for patients in Arizona and beyond.

An experienced practitioner specializing in holistic and alternative medicine, Dr. Rooh offers personalized treatments for patients in Gilbert, Chandler and the surrounding areas of Arizona.

A satisfied patient said: As a new patient I was beyond impressed with this medical facility. During my consultation the kind and approachable Dr. Rooh met with me then his outstanding case manager Casi spent time with me exploring my options for a treatment plan that best suits my needs and situation. I can't express what a wonderful experience this was and I am so excited to be a new patient of theirs.

Interested parties can find more information by visiting the above-mentioned website.

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AskBio Announces First Patient Dosed in Phase 1 Trial Using AAV Gene Therapy for Congestive Heart Failure | DNA RNA and Cells | News Channels -…

Posted: February 4, 2020 at 7:49 pm

DetailsCategory: DNA RNA and CellsPublished on Tuesday, 04 February 2020 18:08Hits: 145

RESEARCH TRIANGLE PARK, NC, USA I February 04, 2020 IAsklepios BioPharmaceutical (AskBio), a clinical-stage adeno-associated virus (AAV) gene therapy company, and its NanoCor Therapeutics subsidiary today announced that the first patient has been dosed in a Phase 1 clinical trial of NAN-101. NAN-101 is a gene therapy that aims to activate protein phosphatase inhibitor 1 (I-1c) to inhibit the activity of protein phosphatase 1 (PP1), a substance that plays an important role in the development of heart failure.

Congestive heart failure (CHF) is a condition in which the heart is unable to supply sufficient blood and oxygen to the body and can result from conditions that weaken the heart muscle, cause stiffening of the heart muscles, or increase oxygen demand by the body tissues beyond the hearts capability.

"Dosing the first patient using gene therapy to target I-1c to improve heart function is a tremendous milestone not only for the AskBio and NanoCor teams but, more importantly, for patients whose quality of life is negatively affected by CHF, said Jude Samulski, PhD, Chief Scientific Officer and co-founder of AskBio. We initially developed this gene therapy as treatment for late-stage Duchenne muscular dystrophy patients who typically die from cardiomyopathy. Following preclinical studies, we observed that heart function improved, which led us to investigate treatment for all types of heart failure.

Were excited to be involved in this novel approach for patients with Class III heart failure, said Timothy Henry, MD, FACC, MSCAI, Lindner Family Distinguished Chair in Clinical Research and Medical Director of The Carl and Edyth Lindner Center for Research at The Christ Hospital in Cincinnati, Ohio, and principal investigator for the study. These patients currently have no other options besides transplant and left ventricular assist devices (LVAD). Today, we started to explore the potential of gene therapy to change their outcomes.

Heart disease is the leading cause of death worldwide, with CHF affecting an estimated 1% of the Western world, including over six million Americans. There is no cure, and medications and surgical treatments only seek to relieve symptoms and slow further damage.

Research by many investigators around the world has been trying to understand what exactly goes wrong in the heart and weakens its pumping activity until it finally fails, said Evangelia (Litsa) Kranias, PhD, FAHA, Hanna Professor, Distinguished University Research Professor and Director of Cardiovascular Biology at the University of Cincinnati College of Medicine. The aim has been to identify potential therapeutic targets to restore function or prevent further deterioration of the failing heart. Along these lines, research on the role of I-1c started over two decades ago, and it moved from the lab bench to small and large animal models of heart failure. The therapeutic benefits at all levels were impressive. It is thrilling to see I-1c moving into clinical trials with the hope that it also improves heart function in patients with CHF.

About the NAN-101 Clinical Trial NAN-CS101 is a Phase 1 open-label, dose-escalation trial of NAN-101 in subjects with NYHA Class III heart failure. NAN-101 is administered directly to the heart via an intracoronary infusion by cardiac catheterization in a process similar to coronary angioplasty, commonly used to deliver treatments such as stem cells to patients with heart disease. The primary objective of the study is to assess the safety of NAN-101 for the treatment of NYHA Class III heart failure, as well as assess the impact of this treatment on patient health as measured by changes in exercise capacity, heart function and other factors including quality of life.

AskBio is actively enrolling patients with NYHA Class III heart failure to assess three doses of NAN-101. Please refer to clinicaltrials.gov for additional clinical trial information.

Would you like to receive our AskFirst patient engagement program newsletter? Sign up at https://www.askbio.com/patient-advocacy.

About The Christ Hospital Health Network The Christ Hospital Health Network is an acute care hospital located in Mt. Auburn with six ambulatory centers and dozens of offices conveniently located throughout the region. More than 1,200 talented physicians and 6,100 dedicated employees support the Network. Its mission is to improve the health of the community and to create patient value by providing exceptional outcomes, the finest experiences, all in an affordable way. The Network has been recognized by Forbes Magazine as the 24th best large employer in the nation in the magazines Americas 500 Best Large Employers listing and by National Consumer Research as the regions Most Preferred Hospital for more than 22 consecutive years. The Network is dedicated to transforming care by delivering integrated, personalized healthcare through its comprehensive, multi-specialty physician network. The Christ Hospital is among only eight percent of hospitals in the nation to be awarded Magnet recognition for nursing excellence and among the top five percent of hospitals in the country for patient satisfaction. For more than 125 years, The Christ Hospital has provided compassionate care to those it serves.

About AskBioFounded in 2001, Asklepios BioPharmaceutical, Inc. (AskBio) is a privately held, clinical-stage gene therapy company dedicated to improving the lives of children and adults with genetic disorders. AskBios gene therapy platform includes an industry-leading proprietary cell line manufacturing process called Pro10 and an extensive AAV capsid and promoter library. Based in Research Triangle Park, North Carolina, the company has generated hundreds of proprietary third-generation AAV capsids and promoters, several of which have entered clinical testing. An early innovator in the space, the company holds more than 500 patents in areas such as AAV production and chimeric and self-complementary capsids. AskBio maintains a portfolio of clinical programs across a range of neurodegenerative and neuromuscular indications with a current clinical pipeline that includes therapeutics for Pompe disease, limb-girdle muscular dystrophy type 2i/R9 and congestive heart failure, as well as out-licensed clinical indications for hemophilia (Chatham Therapeutics acquired by Takeda) and Duchenne muscular dystrophy (Bamboo Therapeutics acquired by Pfizer). For more information, visit https://www.askbio.com or follow us on LinkedIn.

SOURCE: Asklepios BioPharmaceutical

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What is Diabetes? | NIDDK

Posted: February 4, 2020 at 7:48 pm

In this section:

Diabetes is a disease that occurs when your blood glucose, also called blood sugar, is too high. Blood glucose is your main source of energy and comes from the food you eat. Insulin, a hormone made by the pancreas, helps glucose from food get into your cells to be used for energy. Sometimes your body doesnt make enoughor anyinsulin or doesnt use insulin well. Glucose then stays in your blood and doesnt reach your cells.

Over time, having too much glucose in your blood can cause health problems. Although diabetes has no cure, you can take steps to manage your diabetes and stay healthy.

Sometimes people call diabetes a touch of sugar or borderline diabetes. These terms suggest that someone doesnt really have diabetes or has a less serious case, but every case of diabetes is serious.

The most common types of diabetes are type 1, type 2, and gestational diabetes.

If you have type 1 diabetes, your body does not make insulin. Your immune system attacks and destroys the cells in your pancreas that make insulin. Type 1 diabetes is usually diagnosed in children and young adults, although it can appear at any age. People with type 1 diabetes need to take insulin every day to stay alive.

If you have type 2 diabetes, your body does not make or use insulin well. You can develop type 2 diabetes at any age, even during childhood. However, this type of diabetes occurs most often in middle-aged and older people. Type 2 is the most common type of diabetes.

Gestational diabetes develops in some women when they are pregnant. Most of the time, this type of diabetes goes away after the baby is born. However, if youve had gestational diabetes, you have a greater chance of developing type 2 diabetes later in life. Sometimes diabetes diagnosed during pregnancy is actually type 2 diabetes.

Less common types include monogenic diabetes, which is an inherited form of diabetes, and cystic fibrosis-related diabetes.

As of 2015, 30.3 million people in the United States, or 9.4 percent of the population, had diabetes. More than 1 in 4 of them didnt know they had the disease. Diabetes affects 1 in 4 people over the age of 65. About 90-95 percent of cases in adults are type 2 diabetes.1

You are more likely to develop type 2 diabetes if you are age 45 or older, have a family history of diabetes, or are overweight. Physical inactivity, race, and certain health problems such as high blood pressure also affect your chance of developing type 2 diabetes. You are also more likely to develop type 2 diabetes if you have prediabetes or had gestational diabetes when you were pregnant. Learn more about risk factors for type 2 diabetes.

Over time, high blood glucose leads to problems such as

You can take steps to lower your chances of developing these diabetes-related health problems.

[1] Centers for Disease Control and Prevention. National diabetes statistics report, 2017. Centers for Disease Control and Prevention website. http://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf (PDF, 1.3 MB) . Updated July, 18 2017. Accessed August 1, 2017.

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Evaluating the Impact of Diabetes on the Performance of Algorithms for the Detection of AMI Without ST-Elevation – The Cardiology Advisor

Posted: February 4, 2020 at 7:48 pm

The performance of the European Society of Cardiology (ESC) algorithm, ESC 0/1-h, in ruling out acute myocardial infarction (AMI) without ST-elevation was comparable in patients with and without diabetes mellitus (DM), according to a study published in Diabetes Care.

The ESC 0/1-h and 0/3-h algorithms are used to diagnose patients with suspected acute non-ST-elevation myocardial infarction (NSTEMI). The levels of high-sensitivity cardiac troponin (hs-cTn) are often chronically elevated in individuals with DM, rendering it difficult to identify NSTEMI in this patient population. Investigators sought to assess whether the presence of DM affects the diagnostic abilities of 2 ESC algorithms in patients presenting to the emergency department with symptoms indicative of AMI.

In this secondary analysis of 2 studies, the Biomarkers in Acute Cardiac Care (BACC) and stenoCardia trials (ClinicalTrials.gov identifiers NCT02355457 and NCT03227159, respectively), 3,681 patients (mean age, 64.0 years; 64.2% men) with prospectively evaluated suspected acute NSTEMI with (n=563) and without DM, were enrolled. Data from the Advantageous Predictors of Acute Coronary Syndromes study (APACE; n=2895; ClinicalTrials.gov identifier NCT00470587) were used to calculate and externally validate alternative cutoffs for the algorithms.

The levels of hs-cTn were measured at admission, 1 hour (only in the BACC study), and 3 hours (in both studies). Negative and positive predictive values (NPV and PPV, respectively) for NSTEMI were calculated for both algorithms. The studys primary safety outcome was the NPV for NSTEMI (ie, for ruling out the condition), and the primary efficacy outcome was the PPV for ruling in NSTEMI. The sensitivity and specificity of both algorithms were the studys secondary endpoints.

Of 563 participants with DM, 137 (24.3%) had comorbid acute NSTEMI, compared with 15.9% of patients without DM (P <.001). Participants with DM were older and had more cardiovascular risk factors and comorbidities.

The ESC 0/1-h algorithm had a comparable NPV for NSTEMI in patients with and without DM (absolute difference [AD], -1.50; 95% CI, -5.95 to 2.96; P =.54), but the ESC 0/3-h algorithm had a lower NPV in patients with vs without DM (AD, -2.27; 95% CI, -4.47 to -0.07; P =.004). The diagnostic performance to rule-in NSTEMI was comparable for patients with vs without DM with both algorithms: ESC 0/1-h (AD, -6.59; 95% CI, -19.53 to 6.35; P =.34) and ESC 0/3-h (AD, 1.03; 95% CI, -7.63 to 9.7; P =.88).

The sensitivity for ruling out NSTEMI was comparable in patients with vs without DM with both ESC0/1-h (AD, -0.9; 95% CI, -5.1 to 3.3; P =1.00) and ESC 0/3-h (AD, -4.0; 95% CI, -10.4 to 2.4; P =.19) algorithms. The specificity for ruling in NSTEMI was higher for patients without vs with DM when using both the ESC 0/1-h (AD, -6.9; 95% CI -12.5 to -1.2; P =.0035) and ESC 0/3-h (AD, -4.4; 95% CI, -8.2 to 0.6; P =.01) algorithms. The use of alternative cutoffs improved the PPV of both algorithms.

Study strengths include large sample sizes and external validation of proposed alternative cutoffs. Study limitations include the sole use of data from the BACC study to evaluate the 0/1-h algorithm, possible misclassification of AMI and DM, and a lack of accounting for disease duration.

Although alternative cutoffs might be helpful, patients with DM remain a high-risk population in whom identification of AMI is challenging and who require careful clinical evaluation, noted the authors.

Reference

Haller PM, Boeddinghaus J, Neumann JT, et al. Performance of the ESC 0/1-h and 0/3-h algorithm for the rapid identification of myocardial infarction without ST-elevation in patients with diabetes. Diabetes Care. 2019;43(2):460-467. doi: 10.2337/dc19-1327

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Evaluating the Impact of Diabetes on the Performance of Algorithms for the Detection of AMI Without ST-Elevation - The Cardiology Advisor

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Local diabetes advocate to be guest at State of the Union – WFLA

Posted: February 4, 2020 at 7:48 pm

TAMPA, Fla. (WFLA) A young activist from Tampa Bay has been invited to sit with Rep. Charlie Crist (D-FL 13th District) during President Donald Trumps State of the Union address in Washington D.C. Tuesday.

Taylor McKenny, 19, was diagnosed with type 1 diabetes at a young age and has been an advocate for affordable access to insulin and other diabetes treatment.

McKenny says her family has struggled to pay for her medication and nearly went bankrupt.

On Monday, she joined Crist to talk about how lawmakers can help lower prescription drug prices for diabetes patients and hold drug companies accountable.

Last year, Crist supported Elijah E. Cummings Lower Drug Costs Now Act, which passed 230-192.

The bill allows the Secretary of Health and Human Services to negotiate lower drug prices, and caps annual out-of-pocket costs for people in Medicare Part D.

For too long, Americans have been squeezed by high drug prices, while drug companies make record profits, said Rep. Crist. For too long, too many Americans have had to ration their medications, risking illness, injury, and death because their life saving drugs cost too much. But with passage of the Elijah Cummings Lower Drug Costs Now Act, a new day is dawning, one in which the playing field is leveled, and the buying power of the American people is brought to bear on the pharmaceutical industry, resulting in lower prices for all.

Now Crist is planning to push legislation that would lower the price of insulin down to Medicaid levels.

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Type 2 Diabetes Apps Help With Modest Weight Loss, Review Finds – Everyday Health

Posted: February 4, 2020 at 7:48 pm

Mobile apps might help some obese or overweight people with type 2 diabetes shed excess pounds (lbs), but a recent review also suggests that results may be modest at best.

For thepaper, published in January 2020 in Obesity, researchers looked at changes in waist circumference, weight, and body mass index (BMI) in 2,129 people with type 2 diabetes who participated in one of 14 different clinical trials testing a variety of mobile apps for diabetes self-management. These trials randomly assigned some participants to use apps, while others did not, and interventions lasted between 3 and 12 months.

By the end of the trials, people who used diabetes apps lost an average of 0.84 kilograms (about 1.9 lbs) more than participants who didnt. With mobile apps, people also reduced their waist circumference by 1.35 centimeters (about inch) more on average.

BMI appeared lower with apps than without these tools, but the difference was too small to rule out the possibility that it was due to chance.

Reductions in weight, waist circumference, and BMI appeared more pronounced when people were obese and when participants used apps in combination with other interventions designed to promote healthy eating and exercise habits. Some of the trials in the analysis allowed participants to pursue other approaches to weight loss with or without also using a mobile app to manage diabetes.

Mobile application interventions combined with other behavior components lead to a larger magnitude of weight loss, says senior study author Mingzi Li, PhD, of Peking University in Beijing. However, the mobile application functionalities do not moderate weight loss significantly.

Face-to-face or supervised lifestyle modification programs have long been considered a cornerstone of diabetes care, Dr. Li and colleagues wrote. Obesity is a risk factor for developing diabetes and for experiencing potentially serious complications, like blindness, amputations, kidney failure, heart attacks, and strokes.

People who lose at least 5 percent of their body weight in the first year after a diabetes diagnosis may cut their 10-year risk of events like heart attacks and strokes roughly in half, according to a study published in May 2019 in Diabetologia.

And people who lose less weight may still see benefits. Patients with diabetes who lost no more than 2.5 percent of their body weight, for example, were able to lower their blood sugar, cholesterol, and blood pressure, according to a review and meta-analysis published in June 2016 in Obesity Reviews.

RELATED: The Best Apps for Managing Diabetes

In the current study, people typically lost less than 2.5 percent of their body weight. This doesnt seem like much, but it might be enough for them to see improvements in blood sugar, cholesterol, and blood pressure, Li and colleagues wrote.

Weight loss didnt appear to be influenced by whether apps had certain features, like tracking physical activity, logging food, counting calories, monitoring weight, or monitoring or recording blood sugar levels.

This might be because all studied mobile apps had four to five functionalities on average, and it is therefore difficult to distinguish between individual effects, Li said.

At the start of the trials, participants were 58 years old on average and had an average BMI of 30, meaning they typically had obesity.

People who started out with a higher BMI appeared to benefit more from using apps. For each additional unit in BMI as measured at the start of the trials, people using apps achieved of 0.15 kilograms (about 0.3 lbs) more weight loss on average.

RELATED: Most Type 2 Diabetes Apps Fall Short in Helping Users Manage Blood Sugar

Even though the current study pooled results from randomized controlled clinical trials considered the gold standard for medical research there are still some limitations.

One big drawback is that the studies didnt provide long-term weight loss outcomes, particularly because so many people who lose weight struggle to keep it off.

Another limitation is that the results dont show what types of apps or features within apps might help the most with weight loss.

More research is needed to determine whether apps might help people who dont have time or money to do face-to-face appointments with psychologists, nutritionists, or other clinicians who might help them develop and stick to a weight loss plan, Li and colleagues pointed out.

Its possible, they argue, that apps might help some busy people stick with weight loss efforts because its easier and more convenient to use a smartphone every day to monitor progress than it is to go to checkups.

People with diabetes who try and fail to lose substantial amounts of weight using only an app shouldnt be discouraged that they dont get results, says Susan Roberts, PhD, a professor of nutrition at Tufts University in Boston and founder of iDiet.

Dont feel guilty if an app isnt helping you, Dr. Roberts says. They dont help the average person much based on these results, and there are other ways to lose weight.

Whether or not people use apps, regular monitoring of progress with lifestyle changes and weight loss efforts is one key to success, according to the Centers for Disease Control and Prevention.

Besides mobile app interventions, there has been a growing evidence that interventions like step counters could be effective in weight loss as well, Li said. If combined with additional behavior change components, including multidisciplinary diabetes care management or health coaching, they will be more effective.

RELATED: Smart Health: I Tried Noom for Weight Loss and It Worked

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How These Diabetes Experts Stabilized Their Blood Sugar With Food Alone – mindbodygreen.com

Posted: February 4, 2020 at 7:48 pm

"I was doing the exact opposite of a traditional diabetes modelI was eating more carbohydrate energy than I'd ever eaten before," Khambatta explains. "I was eating 600 grams of carbohydrate energy per day, and my insulin use got cut by 35 to 40%."

"I started eating lots of fruits and vegetables," Barbaro adds. "I increased my carbohydrate content and had a 22-to-1 carbohydrate-insulin ratio." In case you aren't familiar with the technical language, that means his insulin sensitivity changed by 600%.

It's important to note the distinction between whole carbs and processed, refined carbs here (it's always good to have a reminder!). Barbaro and Khambatta are partial to the four main carbohydrate categories: fruits,starchy vegetables, beans and legumes, and whole grains.

"The type of carbohydrate you eat absolutely matters," Khambatta says. That said, these experts are encouraging you to eat sweet potatoes, not french fries.

There is some nuance (Khambatta is partial to chickpeas and lacinato kale, while Barbaro loves his sweet potatoes), but the two agree that carbs are essential for long-term health. In terms of their favorite carbs to have on their plates, they agree on fruit as the No. 1 option. "Bananas, mangoes, papayas, pears, jackfruit, you name it. That's our personal favorite, no question."

Even if you don't necessarily suffer from type 1 diabetes, these whole carbohydrate-rich foods are packed with vitamins, fiber, and phytochemicals that increase your overall nutrient densitysomething we all ultimately want, no?

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