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All of the Sci-Fi Stories We Published This Year – Slate

Posted: January 2, 2020 at 12:53 am

Illustrations by Lisa Larson Walker, Franco Zacharzewski, Natalie Matthews-Ramo, and Sarula Bao.

Future Tense started experimenting with publishing science fiction in 2016 and 2017, but we really invested in it in 2018, publishing one story each month. That year was capped off by Annalee Newitzs quirky and urgent When Robot and Crow Saved East St. Louis, which won the Theodore Sturgeon Memorial Award for the best short science fiction of the year. Our hope was that these glimpses into possible futures could provide a thought-provoking parallel to our coverage of emerging technology, policy, and society today, inviting us to imagine how the decisions were making today might shape the way we live tomorrow, illuminating key decision points and issues that we might not be giving enough attention.

In 2019, buoyed by the enthusiastic reactions of our readers, we published 12 stories by a diverse array of talented authors. Every story is paired with a response essay by an expert who provides additional context and delves into themes and challenges raised by the fictionand each story comes with arresting original illustrations in a plethora of styles, from bracing realism to mind-bending abstraction and surrealism. Each quarter is organized around a broad theme, giving us the chance to create a dialogue among the pieces and underlining our conviction that the future is a spectrum of possibilities, shaped by our collective decisionsnot a fait accompli or a foregone conclusion.

This October, we celebrated another milestone, publishing our first anthology, Future Tense Fiction: Stories of Tomorrow, with Unnamed Press. The book, which collects our short stories from 2016 through 2018, received starred reviews from Publishers Weekly and Kirkus. We launched the anthology with scintillating public conversations with fiction authors, experts, and others in Washington, San Francisco, New York, and Phoenix.

Were more convinced than ever of the power of science fiction to expand our sense of empathy for people whose identities and day-to-day experiences are vastly different from our owneven beyond the bounds of what we currently consider human. This year, many of our authors grappled with issues of difference, exclusion, and inequality; with bullying and abusive behavior, from the schoolyard to the space station; with the dangers of alienation in digital spaces, and the opacity of technologies designed solely for profit; and with radical possibility and hope, from giant nutritious plants grown in space to entirely new forms of music and self-expression enabled by technological change. In a moment where the future seems impossibly turbulent, leaving us feeling powerless, science fiction can help us get our heads around the complexity, reminding us of the human minds, relationships, and problems buried under branding, hype, and jargon.

Future Tense Fiction will continue in 2020, with a new story, essay, and illustration each month. The first theme of the year (we couldnt resist): politics.

You can find all of our stories on the Future Tense Fiction landing page, and sign up for the Future Tense newsletter to get notified whenever we publish something new. (Its been on hiatus for a little while, but it will be back in 2020.) And dont forget to follow Future Tense on Twitter.

Thoughts and Prayers, by Ken Liu: A family grieving in the wake of a mass shooting finds themselves in a maelstrom of abusive, inescapable trolling powered by cutting-edge artificial intelligence.

Response essay: Whats in It for the Trolls? by digital culture researcher Adrienne Massanari

Mpendulo: The Answer, by Nosipho Dumisa: Two genetically modified young people navigate bullying and prejudice, and discover the secrets locked inside their DNA, in a world wracked by anxiety after a pandemic.

Response essay: Why Are We So Afraid of Each New Advance in Reproductive Technology? by journalist Sarah Elizabeth Richards, who often reports on reproductive technology and genomics

The Arisen, by Louisa Hall: A fairy tale from a future where truth-checkers, an elite caste implanted with chips that suppress emotion, are charged with sorting official fact from distortion and fiction.

Response essay: What Are Facts Without Fiction? by librarian Jim ODonnell

The Song Between Worlds, by Indrapramit Das: An overprivileged teen dragged to Mars on a family vacation stumbles beyond the cushy confines of their resort and encounters an entirely new form of musical performance.

Response essay: What Would Sound Be Like on Mars? by astronomer Lucianne Walkowicz

No Moon and Flat Calm, by Elizabeth Bear: A team of safety engineering students in a spacefaring future are plunged into a real disaster.

Response essay: How Will People Behave in Deep Space Disasters? by disaster journalist Amanda Ripley

Space Leek, by Chen Qiufan: An astrobotanist for the China National Space Administration, assigned to a distant space station, contends with stifling family expectations while researching how to successfully grow food off-worldand deals with a sudden, deadly crisis.

Response essay: What Will Humans Really Need in Space? by architecture professor Fred Scharmen

Zero in Babel, by E. Lily Yu: In a world where on-demand and even DIY genetic modification is commonplace, a young woman struggles to keep up with the punishing cycle of high school trends.

Response essay: The Future Will Grind On, by law professor Diana M. Bowman

What the Dead Man Said, by Chinelo Onwualu: A woman returns to her hometown in Nigeria after her fathers death, opening old wounds, in a future entirely reshaped by migration and climate chaos.

Response essay: The Scars of Being Uprooted, by journalist Valeria Fernndez, who frequently covers immigration

Double Spiral, by Marcy Kelly: An at-home DNA testing company turns to targeted advertising after a privacy scandal and a spate of new regulations, and a researcher at the firm uncovers a shattering conspiracy.

Response essay: Crossing the Germline, by bioethicist Josephine Johnston

Affordances by Cory Doctorow: People from all walks of lifefrom migrants and hapless teens to tech CEOsfind themselves in the clutches of terrible algorithms and search for ways to evade, confound, and even reclaim these technologies of oppression.

Response essay: Not Just a Number, by artist and educator Nettrice Gaskins

A Priest, a Rabbi, and a Robot Walk Into a Bar, by Andrew Dana Hudson: A rabbinical school dropout and a seminary dropout start a company that trains algorithms to be sensitive to issues of faith and beliefand find themselves in an escalating series of ethical conundrums.

Response essay: A.I. Could Bring a Sea Change in How People Experience Religious Faith, by Slates Ruth Graham, who often writes about religion

Actually Naneen, by Malka Older: In a future where artificially intelligent nannies are the norm for the wealthy, a mother copes with complicated emotions when her familys nanny becomes buggy and perhaps obsolete.

Response Essay: What Role Should Technology Play in Childhood? by digital humanities professor Ed Finn

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Ten books on thinking about thinking – Moneyweb.co.za

Posted: January 2, 2020 at 12:53 am

Christmas is behind us and the new year is upon us, there may be some time to find a new read.

So here are a few books I will read, or atleaststart. What attracted me to these books is how they approachthinking about thinking: Each tries to tease out why our general understanding on a subject is so often wrong; they explore better cognitive frameworks that could help us comprehend issues more clearly; they consider unique perspectives in securities trading, national security, genetics and artificial intelligence.

On to the reading:

No. 1. Behave: The Biology of Humans at Our Best and Worst by Robert M. Sapolsky.

The professor of biology and neurological sciences at Stanford University (and a MacArthur Fellowship winner in 1987) takes a deep examination into the most basic question of human behaviour: Why do we do the things we do?

He probes the things that influence and determine behaviour: neurology, endocrinology, structural development of the nervous system, culture, ecology and the millions of years of evolution. Why we do what we do turns out to be even more complicated than you might have imagined.

No. 2. The Mosquito: A Human History of Our Deadliest Predator by Timothy C. Winegard.

Forget sharks, terrorists or guns: Mosquitoes have killed more people than all other factors in historycombined. Of the 108 billion humans who have ever lived, almost half 52 billion have died from mosquito-borne illnesses. For 190 million years, the mosquito has been waging a war against the rest of the planet, and for all of that history we have been fighting a mostly losing battle.

This has long been one of my very favourite topics; I am thrilled there is finally a book dedicated to it.

No. 3. The Man Who Solved the Market: How Jim Simons Launched the Quant Revolution by Gregory Zuckerman.

This is my nominee for finance book of the year: I read it,reviewedit and interviewed the author forMasters in Business. All thats left is to reread it slowly and deliberately, with no purpose other to enjoy the tale of how one brilliant man saw the markets in a different way from everyone else.

No. 4. Hacking Darwin: Genetic Engineering and the Future of Humanity by Jamie Metzl.

What will happen to children, lifespans, the plant and the animal world when humans begin to retool the worlds genetic code? Metzl tackles the risks and potential rewards to tinkering with the determinants of life as if theyre just another piece of software.

No. 5. Biased: Uncovering the Hidden Prejudice That Shapes What We See, Think, and Do by Jennifer L. Eberhardt.

Investors know that unconscious bias is at work all the time, undermining our goals. What we may not realize is how bias infects our visual perception, attention, memory and actions. The author suggests solutions to managing our biases, but I remain skeptical we can get past our own error-prone nature.

No. 6. Range: Why Generalists Triumph in a Specialised World by David Epstein.

Among top performers, specialization is the exception, not the rule. Thats the startling conclusion of Epstein, a journalist with Sports Illustrated and ProPublica. Considering some of the worlds most successful athletes, artists, inventors, scientists and business people, he found that it was the generalists who excelled, not the specialists.

No. 7. The Spy and the Traitor: The Greatest Espionage Story of the Cold War by Ben Macintyre.

What colleagues, institutions and competitors do you trust? How does counterintelligence and disinformation affect how we make decisions? These issues are explored in this nonfiction tale of the three-way Cold War game of espionage between the US, the UK and the Soviet Union.

No. 8. Trick Mirror: Reflections on Self-Delusion by Jia Tolentino.

Tolentino looks at the basic building blocks of social media and how we use it to deceive not so much others as ourselves. This series of essays tracks among other things the evolution of the internet from a band of enthusiastic geeks and hackers to the trolls and agents of agitprop that have taken over.

No. 9. Talking to Strangers: What We Should Know about the People We Dont Know by Malcolm Gladwell.

Communication breakdown is the focus in this tour of errors, miscommunication and lies. One of our eras most engaging storytellers, Gladwell roams from Fidel Castro to Bernie Madoff and lots of folks in between. His big premise: the default condition of our species is to assume others tell the truth. This makes all of us vulnerable to the deceptions of politicians, salespeople and con artists.

No. 10. Prediction Machines: The Simple Economics of Artificial Intelligence, by Ajay Agrawal, Joshua Gans and Avi Goldfarb.

What happens if we rethinkthe concept of artificial intelligence as a drop in the cost of prediction? That is the question tackled by the three authors of this book, all economists at the University of Torontos Rotman School of Management. The conclusion is that AI, instead of complicating human affairs, may improve decision-making.

2019Bloomberg L.P.

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The Top Ten Most-Read Futurism Stories of 2019 – Futurism

Posted: January 2, 2020 at 12:53 am

A WILD RIDE. Those, by and large, are the first words that come to mind looking back on Futurisms 2019 and all the news that made up these past twelve months.

We ran thousands of stories this year. They ranged from investigative projects, to interviews, to the building blocks of our site: Sharp hour-by-hour analysis on the science and technology narratives of the day. These stories shaped (and are still shaping) the weird, wonderful, frightening, inspiring, and ever-critical present moment were in, to say nothing of the future well occupy on this planet or elsewhere.

That said: Every once in a while, one of these hundreds of stories exceeds our wildest expectations, drawing hundreds of thousands of readers from across the world, and for weeks at a time, too.

To that end and without further ado, here are The Ten Most-Read Futurism Stories of 2019 along with our best guesses as to why they garnered so much attention, and what it might mean for our future.

10. The First Black Hole Photo Is Even More Amazing When You Zoom Out

When: April 12, 2019

What: After the Event Horizon Telescope team unleashed the first-ever image of a black hole, a separate team dropped an incredible follow-up image of the space around it.

Why: A sense of genuine epochal awe surrounded the release of the historic first image of a black hole, for starters. But when we covered NASAs Chandra X-ray Observatory release of the wider shot, showing how distant galaxy M87s black hole was nestled in a boggling vast cloud of high-energy particles, our readers couldnt stop looking. Heck, neither could we.

9. Our Solar System Is Blanketed in a Giant Wall of Fire

When: Nov. 21, 2019

What: Voyager 2 sent back readings suggesting that the edge of the solar system is surrounded by a bubble of 49,427 degrees Celsius (89,000 degrees Fahrenheit) plasma.

Why: We think of the deep solar system as a dark, frozen expanse, but this story showed that its a frontier of extraordinary unknowns that can apparently get, to put it lightly, hot. Even better, NASAs best tool to plumb its mysteries is Voyager 2 a probe thats been traveling away from the Sun since 1977, giving the story an outrageous old-meets-new finishing coat.

8. NASA Engineer Says New Thruster Could Reach 99% Speed of Light

When: Oct. 14, 2019

What: NASA engineer David Burns said that his new thruster design could reach a ludicrous velocity if you give it enough time to accelerate.

Why: The idea of light-speed travel scratches a sci-fi itch, and Burns has a knack for self-promotion. His thrusters undeniably clever it would use a type of particle accelerator to manipulate the speed of an ion loop, subtly changing their mass through relativity effects, thus generating a gentle thrust without propellant. Give it enough time, according to Burns, and it could reach 99 percent the speed of light. The caveats? Itd require building an enormous device in space, and itd take an extremely long time to speed up.

7. New Research: Human Civilization Will Likely Collapse by 2050

When: June 3, 2019

What: An Australian climate change analysis reached a Mad Max conclusion: Were screwed, and on a clock.

Why: The last year in news has often felt a touch world-ending, no? To say nothing of the worlds ongoing fascination with post-apocalyptic fiction, from Dawn of the Dead to The Hunger Games. The wide interest in this, though, illustrates our looming fear of a real collapse event especially when the research comes from a former fossil fuel exec. The good news, according to the research, is that drastic environmental policies could pull the planet back in the right direction. Also, lets be real: the art for this one, by Futurism writer Victor Tangermann, was haunting and beautiful.

6. NASA Research: Astronauts Are Getting Clots, Bizarre Blood Flow

When: Nov. 14, 2019

What: A NASA research project seemingly showed astronauts suffering from ominous circulatory problems.

Why: Everybody loves a feel-good story about a successful rocket launch or a shiny experiment on the International Space Station. But its difficult to ignore growing evidence that space is a hostile environment for the human body and this study, which examined ultrasounds from astronauts whod spent time on space station, showed signs of clots and bizarre blood flow. Needless to say, more research is needed, but this could be an opening act to the human space travel story narrative of this era.

5. Here Are New Pics of That Weird Substance China Found on the Moon

When: Sept. 19, 2019

What: China baffled the world when it announced that its rover had found a mysterious substance on the Moon. Then it released a photo.

Why: The implication of Chinas original announcement, which described the substance as gel-like, was that the material was deeply baffling. Thats probably why droves of Futurism readers visited to see the picture for themselves and share their thoughts though, underwhelmingly, the consensus among researchers is that the material, rather than a gel, is probably lunar glass that formed during a meteor strike.

4. A Dense Bullet of Something Blasted Holes in the Milky Way

When: May 15, 2019

What: According to research by a Harvard-Smithsonian scientist, a dense bullet of something punched holes in our home galaxy many years ago.

Why: A lot of our most-read stories this year were epic in scope, but this galactic-scale mystery by Futurism writer Dan Robitzski might take the cake. Gaps in the stellar stream suggest that something one culprit could be a chunk of dark matter, a million times the mass of our Sun crudely tampered with the large-scale structure of the Milky Way. Just like our readers, we were obsessed and well be keeping an eye out for followup astrophysical research to share with them.

3. NASA: Four Astronauts Will Stay on the Moon for Two Weeks

When: Oct. 30, 2019

What: NASA dropped tantalizing new details about its upcoming Moon missions, which include sending four astronauts to the lunar surface for 6.5 days.

Why: Our readers have a longstanding interest in NASAs efforts to return to the Moon, so these rare specifics from the inscrutable space agency were irresistible. Whats more, this new info demonstrated the depth of NASAs ambition: the 6.5 day mission, which will be loaded with at least four expeditions on the lunar surface, will be twice as long a Moon visit as any other in human history.

2. Russian Sub That Caught Fire Possibly Sent to Cut Internet Cables

When: July 3, 2019

What: In the aftermath of a Russian submarine fire, rumors emerged in Russian media that the sub was on a mission to cut undersea internet cables.

Why: Remember the tragic fire that killed 14 Russian sailors this year? Observers pointed out that Moscow was unusually cagey about the incident, refusing to say even whether it had been a nuclear sub. And then, in a pair of bombshell reports, two Russian outlets reported that the vessel had been a secretive craft thats long been speculated to have been designed to sabotage undersea internet cables. Much like other Russian drama in recent years, this one never got a satisfying conclusion but it was a rare glimpse into the murky world of deep-sea espionage.

1. Chinese Scientists Cloned Gene-Edited Monkeys With Horrifying Results

When: Jan. 25, 2019

What: Chinese scientists made five clones of a monkey that had been gene-edited to suffer from serious psychological problems.

Why: Our most-read story all year took a dive into the lurid world of genetic engineering. Scientists in China tinkered with the DNA of a macaque monkey, and then cloned the animal five times the first time a gene-edited primate had ever successfully been cloned. But ethically, Futurisms Kristin Houser explained, the experiment was a mess: the macaques genes had been altered to give it depression, anxiety, sleep problems and a schizophrenia-like condition. Researchers say the altered monkeys will be a valuable research tool for developing new therapies. But, at the same time, its a Jeff VanderMeer-esque sign of the grotesque frontiers of CRISPR and, like our readers, we couldnt look away.

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Why taxpayers should support expanding the GAO | TheHill – The Hill

Posted: January 2, 2020 at 12:53 am

Congress approved $1.4 trillion in new spending last week to avoid another government shutdown over the holidays. Taxpayers are right to be wary whenever Congress pulls out its checkbook. But when it comes to one important line-item, budget hawks should be rooting for more funding, not less.

The Government Accountability Office (GAO) serves as Congresss watchdog and plays a critical role in holding the federal government accountable to the American people. In November, the comptroller general issued the annual Performance and Accountability Report for FY2019, which found that GAOs work, yielded a record $214.7 billion in financial benefits a return of about $338 for every dollar invested in GAO.

Congress has provided $630 million in new funding for GAO a $40 million increase. This new spending will help support the comptroller generals efforts to modernize oversight and improve Congresss ability to anticipate and address critical challenges.

Since 2014, GAOs work has produced $340 billion in savings and more than 6,400 improvements in program and operational improvements across the government, according to the comptroller generals February testimony before Congress.

In addition to its traditional auditing work, GAO recently established a science, technology, assessment, and analytics (STAA) team. The STAA team is focused on enhancing Congresss capacity to assess emerging technologies, auditing federal science and technology programs, and using advanced analytics to improve auditing.

Earlier this month, Dr. Timothy M. Persons, GAOs chief scientist and managing director of science, technology assessment, and analytics, testified that, GAO will continue to build its capacity to respond to congressional demand. STAAs current staff level is about one-half of what was outlined in the April 2019 plan submitted to Congress.

Besides saving taxpayers money in the long run, increasing appropriations for the GAO and investing new resources in the STAA team, in particular will improve Congresss ability to tackle the challenges and opportunities posed by modern science and technology, rather than leaving such matters to executive agencies.

For example, the STAA team recently hired a chief data scientist, who is charged with using data analytics to support existing audit capabilities, including for upcoming reviews of improper payments across government agencies. GAO also created a Center for Strategic Foresight in 2018 focused on identifying, monitoring, and analyzing emerging issues facing policymakers.

First, enhancing auditing through advanced analytics will improve Congresss ability to prevent waste, fraud and abuse GAOs bread and butter. But increasing GAOs ability to provide technical services will also strengthen Congresss ability to conduct oversight of the many executive agencies that have jurisdiction over technical matters.

Lacking sufficient technical expertise, Congress has historically tended to defer to executive agencies. This, in turn, leaves Congress ill-equipped to grapple with many of the most pressing issues that confront it, from cybersecurity and weapons development to artificial intelligence and genetic engineering, to name only a few. As a result, Congress becomes a mere rubber stamp... of the administrative branch of government, as one member memorably put it, rather than a coequal branch of government.

Second, improving Congresss technical capability can also help it to anticipate changes in science and technology. Importantly, the STAA team is positioned to provide key support to Congress and federal agencies to address key high-risk areas, such as protecting national security technology.

Enhancing GAOs science and technology capabilities complements the House of Representatives Select Committee on the Modernization of Congresss bipartisan and unanimous recommendation for reestablishing and restructuring an improved Office of Technology Assessment. A well-resourced Government Accountability Office STAA team need notbe a replacement for recreating and modernizing the Office of Technology Assessment, which many members have advocated for. In fact, both STAA and OTA could mutually support the legislative branchs efforts to improve its oversight of the federal government and address the nations science and technology challenges.

It may seem counterintuitive to ask fiscal conservatives to support expanding Congresss capabilities, especially at a time when resources are scarce and the national debt is $23 trillion. But investing in GAO will yield long-term savings and better equip the Constitutions first branch to do its job.

Garrett Johnson is co-founder and executive director of Lincoln Network. M. Anthony Mills is director of science policy at the R Street Institute.

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New technology will save the planet from climate change, says LEO McKINSTRY – Express.co.uk

Posted: January 2, 2020 at 12:53 am

A sense of looming catastrophe is reinforced by reports of melting glaciers in the Arctic, unprecedented floods in parts of Asia and disappearing islands in the Pacific because of the rise in sea levels.The classic response of environmental campaigners is to demand a green revolution, based on a radical new economic agenda and drastic changes in our lifestyles.

According to the eco-warriors, the salvation of the planet lies in the replacement of hi-tech western consumerism with a culture of self-sacrifice.

Like the po-faced religious puritans of the past, these hectoring zealots argue that environmental disasters are natures revenge on us for our selfish greed.

Therefore, to avoid the apocalypse, we must atone for our sins by accepting endless green bans, taxes and economic recession.

It is a miserable, authoritarian outlook, perfectly captured in the grim rhetoric of Swedish teenager Greta Thunberg, who has become the international champion of the hardline, environmental programme.

In a typically emotive rant at a UN summit last year, Thunberg wailed the politicians had stolen my dreams and my childhood, adding that we are at the beginning of mass extinction and all you talk about is money and fairy tales of eternal economic growth.

But there is an alternative vision for the rescue of the planet, one that is far more uplifting and optimistic.

Instead of seeking to drag us back to a spartan, pre-industrial age, it aims to embrace the future.

Rather than viewing technological innovation as a menace, it wants to harness such progress for the good of mankind.

It is an approach that lies behind the new initiative by Prince William, who announced this week the launch of the most prestigious environmental prize in history in the search for practical solutions for the Earths problems.

Under this ten-year-long project, supported by Sir David Attenborough, five winners will each year receive multimillion-pound awards for the development of ideas to tackle climate change.

Reflecting this bold emphasis on advances in science and engineering, the scheme is entitled Earthshot in an echo of the inspirational US Moonshot programme of the 1960s that pioneered the first Moon landings.

By taking the plunge into environmental politics, there was a danger that Prince William might have come across as just another virtue-signalling, woke celebrity, delivering sanctimonious lectures about green awareness from his affluent cocoon of privilege.

But he has been far too thoughtful, and creative to do that.

Instead, he has come up with a plan that could yield real results rather than just spreading guilt.

In contrast to the bleak propaganda of Thunberg and her fellow fundamentalists, his prizes offer the exciting hope of better times ahead.

The Prince himself rightly referred to the inspiring civilisations we have built through our unique power as human beings to innovate and problem-solve.

He is absolutely right.

The answer to climate change lies with the hard-headed pioneers, not shrill activists.

Tremendous progress is already being made, particularly in the generation of green energy.

Yesterday, the National Grid revealed that 2019 was the cleanest year on record, as energy from sources such as wind, solar and nuclear power outstripped that from fossil fuels.

This can be part of a saga of real environmental progress.

Bolstered by the Princes support, technologists will also find new ways of trapping energy through far more effective storage systems such as batteries or laminate coating.

New, greener forms of transport will be developed, such as electric aircraft and hyperloop trains that can travel at over 700mph.

Crop yields can be enhanced by genetic modification, thereby helping to feed the planet more cheaply.

Above all, the advent of fusion power plants which create energy by combining atoms rather than dividing them will transform supplies, since the process is inherently safe and produces zero emissions.

The stance of the eco-mob is unworkable.

Their whole ethos runs counter to mankinds impulse for improvement.

That is why the radical greens are so intolerant.

In a notorious recent outburst for which she had to apologise, Thunberg herself called for world leaders to be put up against the wall.

But Prince Williams scheme is the opposite.

In place of self-loathing, it is a celebration of the best of mankind.

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The Major Discoveries That Could Transform the World in the Next Decade – Livescience.com

Posted: January 1, 2020 at 10:44 am

The last decade ushered in some truly revolutionary advances in science, from the discovery of the Higgs boson to the use of CRISPR for Sci-Fi esque gene editing. But what are some of the biggest breakthroughs still to come? Live Science asked several experts in their field what discoveries, techniques and developments they're most excited to see emerge in the 2020s.

The universal flu shot, which has eluded scientists for decades, may be one truly groundbreaking medical advances that could show up in the next 10 years.

"It has sort of become a joke that a universal [flu] vaccine is perennially just five to 10 years away," said Dr. Amesh Adalja, an infectious-disease specialist and senior scholar at the Johns Hopkins Center for Health Security in Baltimore.

Related: 6 Flu Vaccine Myths

But now, it appears that this "may actually be true," Adalja told Live Science. "Various approaches to universal flu vaccines are in advanced development, and promising results are starting to accrue."

In theory, a universal flu vaccine would provide long-lasting protection against the flu, and would eliminate the need to get a flu shot each year.

Some parts of the flu virus are constantly changing, while others remain mostly unchanged from year to year. All of the approaches to a universal flu vaccine target parts of the virus that are less variable.

This year, the National Institute of Allergy and Infectious Diseases (NIAID) began its first-in-human trial of a universal flu vaccine. The immunization aims to induce an immune response against a less variable part of the flu virus known as the hemagglutinin (HA) "stem." This Phase 1 study will look at the safety of the experimental vaccine, as well as participants' immune responses to it. Researchers hope to report their initial results in early 2020.

Another universal-vaccine candidate, made by the Israeli company BiondVax, is currently in Phase 3 trials, which is an advanced stage of research that looks at whether the vaccine really is effective meaning that it protects against infection from any strain of flu. That vaccine candidate contains nine different proteins from various parts of the flu virus that vary little between flu strains, according to The Scientist. The study has already enrolled more than 12,000 people, and results are expected at the end of 2020, according to the company.

In the last decade, scientists have successfully grown mini-brains, known as "organoids," from human stem cells that differentiate into neurons and assemble into 3D structures. As of now, brain organoids can only be grown to resemble tiny pieces of a brain in early fetal development, according to Dr. Hongjun Song, a professor of neuroscience at the Perelman School of Medicine at the University of Pennsylvania. But that could change in the next 10 years.

"We could really model, not just cell type diversity, but the cellular architecture" of the brain, Dr. Song said. Mature neurons arrange themselves in layers, columns and intricate circuits in the brain. Currently, organoids only contain immature cells that cannot forage these complex connections, but Dr. Song said that he expects the field may overcome this challenge in the coming decade. With miniature models of the brain in hand, scientists could help deduce how neurodevelopmental disorders unfold; how neurodegenerative diseases break down brain tissue; and how different peoples' brains might react to different pharmacological treatments.

Someday (though perhaps not in 10 years), scientists may even be able to grow "functional units" of neural tissue to replace damaged areas of the brain. "What if you have a functional unit, pre-made, that you could click into the damaged brain?" Song said. Right now, the work is highly theoretical, but "I think in the next decade, we'll know" whether it could work, he added.

In this decade, rising sea levels and more extreme climate events revealed just how fragile our beautiful planet is. But what does the next decade hold?

"I think we will see a breakthrough when it comes to action on climate," said Michael Mann, a distinguished professor of meteorology at Penn State University. "But we need policies that will accelerate that transition, and we need politicians who will support those policies," he told Live Science.

In the next decade, "the transformation of energy and transportation systems to renewables will be well under way, and new approaches and technologies will have been developed that allow us to get there faster," said Donald Wuebbles, a professor of atmospheric sciences at the University of Illinois at Urbana-Champaign. And, "the increasing climate-related impacts from severe weather and perhaps from sea-level rise finally get enough people's attention that we really begin to take climate change seriously."

Good thing too, because based on recent evidence, there's a scarier, more speculative, possibility: Scientists might be underestimating the effects that climate change have had on this century and beyond, Wuebbles said."We should learn much more about that over the next decade."

Related: The Reality of Climate Change: 10 Myths Busted

In the last decade, the biggest news in the world of the very small was the discovery of the Higgs boson, the mysterious "God particle" that lends other particles their mass. The Higgs was considered the crowning jewel in the Standard Model, the reigning theory that describes the zoo of subatomic particles.

But with the Higgs discovered, many other less-famous particles began taking center stage.This decade, we have a reasonable shot at finding another of these elusive, as-yet-still hypothetical particles the axion, said physicist Frank Wilczek, a Nobel laureate at the Massachusetts Institute of Technology. (In 1978, Wilczek first proposed the axion). The axion is not necessarily a single particle, but rather a class of particles with properties that rarely interact with ordinary matter. Axions could explain a long-standing conundrum: Why the laws of physics seem to act the same on both matter particles and their antimatter partners, even when their spatial coordinates are flipped, as Live Science previously reported.

Related: Strange Quarks and Muons, Oh My! Nature's Tiniest Particles Dissected

And axions are one of the leading candidates for dark matter, the invisible matter that holds galaxies together.

"Finding the axion would be a very great achievement in fundamental physics, especially if it happens through the most likely path, i.e., by observing a cosmic axion background which provides the 'dark matter.'" Wilczek said. "There's a fair chance that could happen in the next five to 10 years, since ambitious experimental initiatives, which could get there, are blossoming around the world. To me, weighing both the importance of discovery and likelihood of it happening, that's the best bet."

Among those initiatives is the Axion Dark Matter Experiment (ADMX) and the CERN Axion Solar Telescope, two major instruments that are hunting for these elusive particles.

That said, there are other possibilities too we may yet detect gravitational waves, or ripples in spacetime, emanating from the earliest period in the universe, or other particles, known as weakly interacting massive particles, that could also explain dark matter, Wilczek said.

On Oct. 6, 1995, our universe got bigger, sort of, when a pair of astronomers announced the discovery of the first exoplanet to orbit a sun-like star. Called 51 Pegasi b, the orb showed a cozy orbit around its host star of just 4.2 Earth days and a mass about half that of Jupiter's. According to NASA, the discovery forever changed "the way we see the universe and our place in it." More than a decade later, astronomers have now confirmed 4,104 worlds orbiting stars outside of our solar system. That's a lot of worlds that were unknown just over a decade ago.

So, the sky's the limit for the next decade, right? According to Massachusetts Institute of Technology's Sara Seager, absolutely. "This decade will be big for astronomy and for exoplanet science with the anticipated launch of the James Webb Space Telescope [JWST]," said Seager, a planetary scientist and astrophysicist. The cosmic successor to the Hubble Space Telescope, JWST is scheduled to launch in 2021; for the first time, scientists will be able to "see" exoplanets in infrared, meaning they can spot even faint planets that orbit far off from their host star.

What's more, the telescope will open a new window into the characteristics of these alien worlds. "If the right planet exists, we will be able to detect water vapor on a small rocky planet. Water vapor is indicative of liquid water oceans since liquid water is needed for all life as we know it, this would be a very big deal," Seager told Live Science. "That's my number one hope for a breakthrough." (The ultimate goal, of course, is to find a world that has an atmosphere similar to that of Earth's, according to NASA; in other words, a planet with conditions capable of supporting life.)

And of course, there will be some growing pains, Seager noted. "With the JWST, and the extremely large ground-based telescopes anticipated to come online, the exoplanet community is struggling to transform from individual or small team efforts to large collaborations of dozens or over one hundred people. Not huge by other standards (e.g., LIGO) but it's tough nonetheless," she said, referring to the Laser Interferometer Gravitational-Wave Observatory, a huge collaboration that involves more than 1,000 scientists across the globe.Originally published on Live Science.

Originally published on Live Science.

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Firm adds a new wrinkle to anti-aging products – The Logan Banner

Posted: January 1, 2020 at 10:44 am

HUNTINGTON Serucell Corporation, a cosmeceutical company based in Huntington, has developed the worlds only dual-cell technology to create and produce anti-aging skincare products, and they did it in Huntington.

Serucell KFS Cellular Protein Complex Serum is made start to finish at Serucells laboratory on the south side of Huntington.

This has been one of the best kept secrets in West Virginia, said Cortland Bohacek, executive chairman and a co-founder of Serucell Corporation.

The company soft launch was in September 2018 at The Greenbrier Spas. The Official online launch was April 2019 and is getting exposure with some well known sellers like Neiman Marcus, local dermatologist and plastic surgeons offices and several other retail locations from New York to California. It is also sold online at serucell.com.

One person that has tried the product is Jennifer Wheeler, who is also a Huntington City Council member.

As a consumer I have an appreciation of the quality of the product and the results Ive seen using it, she said. It has been transformative for my skin and seems like its success will be transformative for our city as well.

She said Serucell and the people behind it are impressive on every level.

In my role on council, Im especially grateful for the companys conscious effort to stay and grow in our city, Wheeler said.

A one-ounce bottle of the serum costs $225. The recommended usage is twice per day and it will last on average of about six weeks.

Serucells active ingredient is called KFS (Keratinocyte Fibroblast Serum), which is made up of more than 1,500 naturally derived super proteins, collagens, peptides and signaling factors that support optimal communication within the cellular makeup of your skin.

This is the first and only dual-cell technology that optimizes hydration and harnesses the power of both keratinocytes and fibroblasts, two essential contributors to maintaining healthy skin by supporting natural rejuvenation of aging skin from the inside out, said Jennifer Hessel, president and CEO of the company.

When applied to the skin, KFS helps boost the skins natural ability to support new collagen and elastin, strengthen the connection and layer of support between the upper and lower layers of your skin. The result, over time is firmer, plumper and smoother skin, according to Hessel.

Why it works so naturally with your skin is because it is natural, Hessel said. These proteins play an important role in strengthening the bond between the layers of your skin, and thats where the re-boot happens.

KFS is the creation of Dr. Walter Neto, Serucells chief science officer and co-founder of the company. Neto is both a physician and a research scientist, specializing in the field of regenerative medicine with an emphasis on skin healing and repair.

Neto said Serucells technology unlocks the key to how our cells communicate and harnesses the signaling power actions to produce the thousands of bioactive proteins necessary to support the skins natural rejuvenation.

Originally from Brazil, Neto studied at Saint Matthews University and completed his clinical training in England. His clinical research on stem-cell cancer therapies, bone and tissue engineering and wound and burn healing led to his discovery in cell-to-cell communication, and ultimately the creation of Serucells KFS Cellular Protein Complex Serum.

Neto received multiple patents for the production method of Serucell KFS Serum. He lives in Huntington with his wife and four golden retrievers and works alongside his longtime friend, Dr. Brett Jarrell.

I have known Brett since I was 18 years old, Neto said.

Jarrell practices emergency medicine in Ashland, Kentucky, and oversees all aspects of quality control for Serucell. He received his bachelors degree in biology from Wittenberg University, his masters degree in biology from Marshall University and his medical degree from the Marshall University School of Medicine. Jarrell completed his residency at West Virginia University and is board certified by the American Board of Emergency Medicine.

Jarrell has served as a clinical instructor of emergency medicine at the Marshall School of Medicine, president of the West Virginia chapter of the American College of Emergency Medicine and he has published a number of peer-reviewed journal articles on stroke research.

Jarrell also lives in Huntington.

Another co-founder of the company is Dr. Tom McClellan.

McClellan is Serucells chief medical officer and director of research and is a well-respected plastic and reconstructive surgeon with a private practice, McClellan Plastic Surgery, in Morgantown.

McClellan completed his plastic and reconstructive surgery training at the world-renowned Lahey Clinic Foundation, a Harvard Medical School and Tufts Medical School affiliate in Boston, Massachusetts. While in Boston, he worked at Lahey Medical Center, Brigham and Womens Hospital, as well as at the Boston Childrens Hospital. McClellan is board certified by the American Board of Plastic Surgery.

In addition to his practice and role at Serucell, McClellan utilizes his surgical skills through pro bono work with InterplastWV, a non-profit group that provides comprehensive reconstructive surgery to the developing world. He has participated in surgical missions to Haiti, Peru and the Bahamas.

McClellan lives in Morgantown with his family.

All three doctors here have strong connections to West Virginia, and we didnt want to leave, Neto said. We all want to give back to West Virginia, so that is the main reason we have our business here in Huntington.

We are building a company we believe can make a difference in the community, Hessel added. Our goal is to grow Serucell and build our brand right here in Huntington. There is a pool of untapped talent here in Huntington. When we expand our business here, we can provide another reason for young people to be able to stay and grow their careers, whether it is in science, operations or manufacturing. The team is a pretty excited to make an impact in the community where it all started.

Hessel decline to give sales numbers, but said the business has been growing each year since the product was introduced. She also declined to give the number of employees at the facility, but did say it has sales representatives across the country.

For more information, visit serucell.com.

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OncoImmune Announces Approval of IND Application for ONC-392 The anti-CTLA-4 Antibody that Preserves CTLA-4 Recycling for Better Safety and Efficacy…

Posted: January 1, 2020 at 10:44 am

DetailsCategory: AntibodiesPublished on Wednesday, 01 January 2020 12:23Hits: 136

ROCKVILLE, MD, USA I December 30, 2019 I OncoImmune, Inc. announced today that its Investigational New Drug (IND) application for ONC-392, its novel, next generation anti-CTLA-4 antibody, has been approved by the U.S. Food and Drug Administration (FDA). The IND approval enables OncoImmune to begin a Phase 1A/1B clinical trial of ONC-392 that is designed to assess the safety, pharmacokinetics, and efficacy of ONC-392 as a single agent in advanced solid tumors and in combination with anti-PD(L)1 standard of care in Non-

ONC-392 was developed based on the research of OncoImmunes Founders, Drs. Yang Liu and Pan Zheng, who proposed a new theory to improve both the efficacy and safety of immunotherapy drugs. The theory calls for preservation of the CTLA-4 immune checkpoint for safer and more effective immunotherapy. (https://www.sciencedirect.com/science/article/pii/S0165614719302639). This groundbreaking research was published in three papers in Cell Research in 2018 and 2019. The two 2018 papers were recognized with the Sanofi-Cell Research Outstanding Paper Award of 2018 (https://www.nature.com/articles/s41422-019-0248-2).

ONC-392 is OncoImmunes second drug product candidate and the approval of this IND is an important milestone for OncoImmune, said Yang Liu, President and CEO of OncoImmune. Unlike other anti-CTLA-4 antibodies that cause lysosomal degradation of CTLA-4, ONC-392 preserves CTLA-4 recycling and thus maintains CTLA-4 function outside of the tumor microenvironment while allowing more effective CTLA-4-targeted depletion of regulatory T cells within the tumor. The truly novel and differentiated mechanism of action of this drug has the potential to improve therapeutic outcomes while significantly reducing toxicity.

We are very excited to test the potential of this novel antibody in cancer patients, said Pan Zheng, Chief Medical Officer of OncoImmune, Inc.

The CMC development and GMP manufacturing of the drug substance and drug product were performed by WuXi Biologics, a leading global open-access biologics technology platform for the ONC-392 program. Throughout the development program from DNA to IND, we were very impressed by WuXi Biologics expertise and professionalism, and we could not have picked a better partner for this project, said Martin Devenport, OncoImmunes Chief Operating Officer.

About OncoImmune, Inc.

OncoImmune (www.oncoimmune.com) is a privately-held, clinical-stage biopharmaceutical company that is actively engaged in the discovery and development of novel immunotherapies for cancer, inflammation and autoimmune diseases. OncoImmune is based in Rockville, Maryland.

OncoImmunes lead product, CD24Fc, is a novel therapeutic that regulates host inflammatory response to tissue injuries and which has broad implications in the pathogenesis of cancer, autoimmune disease, metabolic syndrome and graft-versus-host disease (GvHD). CD24Fc has completed a Phase IIa trial for the prophylactic treatment of acute Graft versus Host Disease (GvHD) in leukemia patients undergoing hematopoietic stem cell transplantation (HSCT) and resulted in a significant improvement in 180 Day Grade III-IV GVHD Free Survival, the Phase III primary endpoint. CD24Fc prophylaxis also resulted in a reduced relapse and, compared to match controls, CD24Fc demonstrated improvement in Overall Survival, Non-Relapse Mortality and Relapse-Free Survival. A dose-dependent reduction in severe (Grade > 3) mucositis was also observed. A 20 patient open label dose expansion cohort at the recommended clinical dose is fully enrolled and the drug continues to perform very well. A Phase III study is anticipated to start in early 2020.

SOURCE: OncImmune

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Conway supports man fighting rare double diagnosis of MS, ALS – THV11.com KTHV

Posted: January 1, 2020 at 10:42 am

CONWAY, Ark. A Conway man has spent many years living with Multiple Sclerosis, but this year he was also diagnosed with ALS, or Lou Gherigs Disease.

For the Nobles family, every day with their father, Greg, is a treasured moment.

"I was first diagnosed 16 years ago with MS," said Greg Nobles.

Life has been a challenge since, but it was this January when his health began to decline severely.

Greg lost all mobility. After getting treated for his symptoms and not seeing a difference is when neurologists confirmed Greg also suffers from ALS, a nervous system disease weakening muscles with no cure.

"Doctors have never seen a patient with both before, said Bailey Smith, Gregs daughter. Being diagnosed MS first, we got 15 good years with him versus the ALS now.

RELATED: A final fundraiser for the man who boosted the ice bucket challenge

Once active and known as one of the best hairstylist in town, Gregs now homebound hoping for relief from the pain he endures.

"My husband passed away from ALS in 2004, so I know the journey they are going on, said Diana Kirkland, a hair client of Gregs.

Kirkland knew she needed to do something for the Nobles.

She owns Legacy Acres in Conway.

This week shes preparing her space for a fundraising event Friday night to raise money so Greg can receive stem cell therapy, an expensive procedure done in Mexico, but one that will reduce his discomfort.

"If I could just get some mobility back, it's worth it, said Greg.

Greg has already received two rounds of stem cell therapy.

RELATED: Arkansas man raises money for charity by streaming 24-hour gaming session

Fortunately, hes starting to notice relief in his left leg.

But with ALS, hes given 3 to 5 years to live, but with a community coming together to help, his family hopes that love and support will give them more time with him.

"It means everything to us, said Smith. To continue to get stem cells for us, my babies to see my dad keep fighting.

Greg Nobles Fundraising Dinner is at Legacy Acres, 100 Legacy Acres Drive, in Conway on Friday night beginning at 6 p.m.

Everyone is invited. The event will have live music, a silent auction, catered food provided by Catering By S and I.

There will also be a donation table set up for a stem cell therapy fund.

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Stroke Therapeutics Market by Type and Geography – Global Forecast and Analysis 2019-2023 – GlobeNewswire

Posted: January 1, 2020 at 10:42 am

Dublin, Dec. 31, 2019 (GLOBE NEWSWIRE) -- The "Stroke Therapeutics Market by Type and Geography - Global Forecast and Analysis 2019-2023" report has been added to ResearchAndMarkets.com's offering.

The stroke therapeutics market analysis considers sales from both ischemic stroke and hemorrhagic stroke types. The analysis also considers the sales of stroke therapeutics in Asia, Europe, North America, and ROW. In 2018, the ischemic stroke therapeutics segment had a significant market share, and this trend is expected to continue over the forecast period. Factors such as availability of patient assistance programs will play a significant role in the ischemic stroke therapeutics segment to maintain its market position. Also, the global stroke therapeutics market report looks at factors such as high-risk factors for stroke, strong pipeline, and growth of the geriatric population. However, high level of genericization in the market, availability of substitutes, and clinical trial failures may hamper the growth of the stroke therapeutics industry over the forecast period.

Globally, stroke is the second-leading cause of death among adults. The high prevalence of stroke is attributed to the increase in the incidence of ischemic strokes and hemorrhagic strokes, mainly because of the increasing presence of high-risk factors over the years. The major risk factors such as high blood pressure, high cholesterol levels and obesity, heart diseases, and diabetes are increasing the number of strokes that results in several deaths across the world. The risk of stroke also increases due to excessive smoking and alcohol consumption. Such risk factors will lead to the expansion of the global stroke therapeutics market at a CAGR of almost 5% during the forecast period.

The global stroke therapeutics market is expected to benefit from the development of novel therapies, such as stem cell therapies. Owing to the high prevalence of stroke, there is a huge need for safe and innovative novel therapies to treat stroke. Therefore, several companies are developing novel drugs for the treatment of stroke. The development of stem cell therapy will have a major impact on upcoming stroke therapeutics, as it has fewer side effects and regenerative properties. Some of the other novel drugs currently under various stages of development in the stroke therapeutics market are PSD-95 antagonist NA-1 developed by NoNO and 3K3A-APC developed by ZZ Biotech LLC. Such development of novel therapies with fewer side effects is expected to have a positive impact on the overall market growth.

With the presence of several major players, the global stroke therapeutics market is fragmented. The robust vendor analysis is designed to help clients improve their market position, and in line with this, this report provides a detailed analysis of several leading stroke therapeutics manufacturers, that include Amgen Inc., AstraZeneca Plc, Bayer AG, Boehringer Ingelheim International GmbH, Bristol-Myers Squibb Co., F. Hoffmann-La Roche Ltd., Johnson & Johnson Services Inc., Merck & Co. Inc., Pfizer Inc., and Sanofi.

Also, the stroke therapeutics market analysis report includes information on upcoming trends and challenges that will influence market growth. This is to help companies strategize and leverage on all forthcoming growth opportunities.

Key Topics Covered:

PART 01: EXECUTIVE SUMMARY

PART 02: SCOPE OF THE REPORT

PART 03: MARKET LANDSCAPEPART 04: MARKET SIZINGPART 05: FIVE FORCES ANALYSISPART 06: MARKET SEGMENTATION BY TYPE

PART 07: CUSTOMER LANDSCAPEPART 08: GEOGRAPHIC LANDSCAPE

PART 09: DECISION FRAMEWORKPART 10: DRIVERS AND CHALLENGES

PART 11: MARKET TRENDSPART 12: VENDOR LANDSCAPE

PART 13: VENDOR ANALYSIS

PART 14: APPENDIX

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/af16zt

About ResearchAndMarkets.comResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

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