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Hormone Replacement Therapy Market Global Strategies and Insight driven transformation 2020 2030 – Info Street Wire

Posted: December 25, 2019 at 12:43 pm

Hormone Replacement Therapy Market research report is a professional and an in-depth study available on the market size, share, growth, trends, in addition to industry evaluation. Hormone Replacement Therapy Market report provides a thorough analysis and competitive analysis by region and added main information like a manufacturing process, raw material and equipment suppliers, various manufacturing associated costs, revenue, historical and futuristic cost, demand and supply data.

Moreover, the study presents a feasible estimate of the current market scenario, including the Hormone Replacement Therapy market size with regards to value and volume. This extensive report is a gathering of significant data related to the competitive scenario of the industry. Further, it encompasses data with regards to various regions that have successfully established its position in the Hormone Replacement Therapy industry.

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Key players profile in the report include (Sales Revenue, Price, Gross Margin, Main Products, etc.):

Merck KgaA, Abbott Laboratories, Eli Lilly and Company, Novartis International AG, Pfizer Inc., Bayer AG, QuatRx Pharmaceuticals, Mylan N.V., Teva Pharmaceutical Industries Ltd., Amgen, Inc., and Novo Nordisk A/S.

Segmentation of the report:

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The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

Scope of Market:

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Testosterone Replacement Therapy Market is Poised to be Worth US$ XX Mn in 2027 – Market Research Sheets

Posted: December 24, 2019 at 10:45 pm

Global Testosterone Replacement Therapy Market Size, Status and Forecast 2019-2027 offers a primary overview of the Testosterone Replacement Therapy industry coveringDefinition, Classification, Industry Value, Price, Cost, and Gross Profit, Share via Region, New Challenge Feasibility Evaluation, Analysis and Guidelines on New mission Investment. Testosterone Replacement Therapy Market report presents the in-intensity insight ofCompany Profile, Capacity, Product Specifications, Production Value, Sales, Revenue, Price, Gross Margin, Market Size and Market Sharesfor topmost prime key vendors. In the end, there are 4 key segments covered in this Testosterone Replacement Therapy market report: competitor segment, product type segment, end use/application segment, and geography segment.

Target Audience of Testosterone Replacement Therapy Market:Suppliers, Channel Partners,Production Companies, Market Consultants,Marketing Authorities, Research Institutions, Subject Matter Experts, Financial Institutions, Government Authorities.

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Testosterone Replacement Therapy Market Summary:This report includes the estimation of market size for value (million US$) and volume (K sqm). Both top-down and bottom-up approaches have been used to estimate and validate the market size of Testosterone Replacement Therapy market, to estimate the size of various other dependent submarkets in the overall market. Key players in the market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All percentage shares split, and breakdowns have been determined using secondary sources and verified primary sources.

Based on Classification,each type is studied as Sales, Testosterone Replacement Therapy Market Share (%), Revenue (Million USD), Price, Gross Margin and more similar information.each type, including:

Market Taxonomy:-

Global Testosterone Replacement Therapy market is segmented on the basis of product type, cereals, distribution channel, and region

By Players By Product Type By Applications By Distribution Channel By Segments

Testosterone Replacement Therapy Market: Regional Analysis Includes:

1. Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)2. Europe(Turkey, Germany, Russia UK, Italy, France, etc.)3. North America(the United States, Mexico, and Canada.)4. South America(Brazil etc.)5. The Middle East and Africa(GCC Countries and Egypt.)

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Industrial Chain, Sourcing Strategy and Downstream Buyers (2019 2027) Industrial Chain Analysis of Testosterone Replacement Therapy market Upstream Raw Materials Sourcing Raw Materials Sources of Testosterone Replacement Therapy Market by Major Manufacturers Downstream Buyers

Testosterone Replacement Therapy Market Capacity, Production, Revenue, Consumption, Export, and Import (2019 2027) Testosterone Replacement Therapy Market Capacity, Production, and Growth Production, Consumption, Export, and Import Revenue and Growth of Market

Testosterone Replacement Therapy Market Forecast (2019 2027) Testosterone Replacement Therapy Market by Capacity, Production, Revenue Forecast Production Forecast by Type and Price Forecast Consumption Forecast by Application Production, Import, Export and Consumption Forecast Testosterone Replacement Therapy Market Production, Consumption, Import and Export Forecast by Regions (Provinces)

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Global Testosterone Replacement Therapy Market Research Report 2020 By Manufacturers, Regions, Types And Applications – Bulletin Line

Posted: December 24, 2019 at 10:45 pm

the global Testosterone Replacement Therapy market. It also includes discussion on historical trends, current market status, competitive landscape, growth opportunities and challenges which are backed by factful feedbacks. The report extensively provides quantitative analysis of the industry from 2014-2026,by Region, Type, Application. Consumption assessment by application, production by type in different regions. Furthermore, the report quantifies the market share held by the major players of the industry and provides an in-depth view of the competitive landscape. The market size in terms of revenue (USD) and production is calculated for the study period along with the details of the factors affecting the market growth (drivers and restraints). The worldwide market for Testosterone Replacement Therapymarket will reach xxx Million USD in 2020 and is expected to grow at a CAGR of xx% 2021-2026.

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Geographically, global Testosterone Replacement Therapy market competition by top manufacturers, with production, price, revenue (value) and market share for each manufacturer; the top players includingAbbVieEndo InternationalEli lillyPfizerActavis (Allergan)BayerNovartisTevaMylanUpsher-SmithFerring PharmaceuticalsKyowa KirinAcerus Pharmaceuticals

On the basis of product, we research the production, revenue, price, market share and growth rate, primarily split intoGelsInjectionsPatchesOther

For the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate of Testosterone Replacement Therapy for each application, includingHospitalsClinicsOthers

Production, consumption, revenue, market share and growth rate are the key targets for Testosterone Replacement Therapy from 2014 to 2026 (forecast) in these regionsChinaUSAEuropeJapanKoreaIndiaSoutheast AsiaSouth America

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Who we areResearch Tradeshas a team of experts who is working on a comprehensive analysis of market research. This estimate is based on a comprehensive study of the future and estimates of future estimates, which can be used by various organizations for growth purposes.We distribute customized reports that focus on meeting the customers specific requirement. Our company provides a large collection of high-quality reports obtained by customer-centered approaches, thus providing valuable research insights.Contact Us:Email: [emailprotected]Call us: +1 6269994607 (USA), +91 7507349866 (IND)Web:www.researchtrades.comSkype ID: researchtradescon

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EPR’s news round-up 2019: the stories that defined the year – European Pharmaceutical Review

Posted: December 24, 2019 at 10:45 pm

This article highlights the 10 most popular news stories published by European Pharmaceutical Review in 2019.

European Pharmaceutical Review has covered a wide range of news stories this year, from recalls to approvals, to clinical trials and patent cases.

As this year comes to an end, we reflect on our biggest and most popular stories from 2019. To read the full pieces, click on the title of each news story.

Kicking off our tenth most popular story was the news that Stelara (ustekinumab), a monoclonal antibody (mAb), had been submitted to the European Medicines Agency (EMA) for approval.

The drug is intended to treat patients with moderate-to-severe ulcerative colitis and is the first mAb to target the interleukin (IL)-12 and IL-23 cytokines, believed to be key in the development of inflammation.

The treatment had previously been submitted in a supplemental Biologics License Application (sBLA) to the US Food and Drug Administration (FDA).

Since January, the drug has been approved for the treatment of the condition for patients who have had an inadequate response with, lost response to or were intolerant to conventional therapy.1

Our next most popular story highlighted the effect of the US government shutdown in January on the FDA. The regulatory body clarified which operations it could carry out during the lack of funding.

According to the FDA, it was able to continue its usual activities that were crucial to ensure public safety in the US.

The statement also emphasised that the agency would guarantee the monitoring and response to emergency situations.

The shutdown ended on 25 January 2019, once President Donald Trump was able to reach a provisional deal with congressional leaders.2

August saw an outbreak of African swine flu in China threaten the supply of a pharmaceutical ingredient to the US.

Stocks of heparin, an ingredient used in anticoagulant drugs and usually derived from pigs, were under pressure as 150 million of Chinas 440 million swine reportedly died as a result of the disease.

Six members of the US Congress wrote a letter to the FDA, outlining their concern for the pharmaceutical supply chain. According to the letter, 60 percent of the crude heparin used to manufacture the finished version of the ingredient in the US is sourced from China.

However, as of October, the FDA reported that the supply of heparin was not affected due to the swine fever.3

In one of many recalls seen this year, the UK Medicines and Healthcare products Regulatory Agency (MHRA) announced an alert in October in regard to Perrigo Companys ranitidine medicines.

The warning came after the discovery of levels of N-nitrosodimethylamine (NDMA), a probable human carcinogen, were found in ranitidine products.

In this case, all unexpired stock of the 150mg/10ml oral solution was recalled and healthcare professionals and retailers were told to cease supply of the medicines.

Since the recall, the EMA has announced that the risk of cancer in humans from the drugs is very low, but that marketing authorisation holders should take precautionary measures to mitigate the risk of nitrosamine formation in medicines.4

In February, the news broke that biologic drugs used to treat severe psoriasis could be used to prevent heart disease in patients with the skin condition. According to a study, after one year of treatment, biologic therapy improved coronary artery plaque, similar to the effect of a low-dose statin.

Systematic inflammation assessed by blood markers also reduced in the group taking biologic therapy, found the researchers.

According to the story, previous research has shown that in heart attack patients, anti-inflammatory biologic therapy reduces the risk of another cardiovascular event.

The study was published in Cardiovascular Research.

In another announcement, the MHRA announced that three batches of Losartan tablets would be recalled in a precautionary measure due to a possible contamination with the nitrosamine N-nitroso-N-methylamino butyric acid (NMBA).

The recall was part of a wider range of sartan medicines affected by potential contamination, a class of drugs to treat blood pressure and heart attacks.

The recent investigation into sartan medicines began in 2018, after NDMA was discovered in valsartan manufactured at a facility based in China.

In August, the FDA released a statement that emphasised the actual risk to patients from sartan medicines is very low and that there are ongoing investigations into the safety of this class of drugs.5

In our fourth most-read story, researchers in Poland and South Korea were reported to have developed a computer model that could be used to synthetically produce essential drugs, bypassing patent-protection.

To overcome the patents in place, the researchers froze the challenging portions from each target molecule, forcing the computer to substitute unconventional but chemically plausible molecules.

The team suggested that their software could help pharmaceutical companies to protect their intellectual properties and increase research into organic chemistry.

The study was published in Cell.

In April, an experimental male oral contraceptive pill called 11-beta-methyl-19-nortestosterone dodecylcarbonate (11-beta-MNTDC) passed human safety tests.

The tablet is formulated with a modified testosterone that has the combined actions of a male hormone (androgen) and a progesterone.

In 40 healthy men, taking the pill was associated with lower testosterone levels, but no side effects were reported, allowing it to pass the test.

According to the researchers, the study indicates that the contraceptive pill decreases sperm production while preserving libido.

The findings were published in The Journal of Clinical Endocrinology and Metabolism.

August saw the story break that the shortage of hormone replacement therapy (HRT) in the UK is likely to continue into 2020. The news led medical experts to call for a resolution to the disruption in supply.

Reportedly, around half of the most commonly prescribed HRT products are out of stock in many pharmacies.

The shortage was due to supply chain issues in China, causing manufacturers to stop production of the therapies. Other brands were consequently in high demand, reducing the availability of most products.

As of November, there were still issues with the HRT supply chain. However, pharmaceutical companies are reportedly addressing these problems and working with manufacturers to solve the issue.6

Our top story this year was in September, when the news broke that the FDA and EMA were investigating some ranitidine medicines after NDMA was detected in some drugs.

Both agencies announced that they would be examining the levels of NDMA found and would take the appropriate measures to protect those taking the medication.

Since then, the FDA has released a statement, after finding that the drugs tested contained no more NDMA than in grilled or smoked meats. However, they also emphasised that manufacturers are encouraged to continue conducting their own testing to ensure the safety of their medicines for patients.7

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EPR's news round-up 2019: the stories that defined the year - European Pharmaceutical Review

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Stem Cell Therapy Market Consumer Outlook 2025 | MEDIPOST Co., Ltd., Osiris Therapeutics, Inc. – Market Research Sheets

Posted: December 24, 2019 at 10:43 pm

Stem Cell Therapy Market: Snapshot

Of late, there has been an increasing awareness regarding the therapeutic potential of stem cells for management of diseases which is boosting the growth of the stem cell therapy market. The development of advanced genome based cell analysis techniques, identification of new stem cell lines, increasing investments in research and development as well as infrastructure development for the processing and banking of stem cell are encouraging the growth of the global stem cell therapy market.

To know Untapped Opportunities in the MarketCLICK HERE NOW

One of the key factors boosting the growth of this market is the limitations of traditional organ transplantation such as the risk of infection, rejection, and immunosuppression risk. Another drawback of conventional organ transplantation is that doctors have to depend on organ donors completely. All these issues can be eliminated, by the application of stem cell therapy. Another factor which is helping the growth in this market is the growing pipeline and development of drugs for emerging applications. Increased research studies aiming to widen the scope of stem cell will also fuel the growth of the market. Scientists are constantly engaged in trying to find out novel methods for creating human stem cells in response to the growing demand for stem cell production to be used for disease management.

It is estimated that the dermatology application will contribute significantly the growth of the global stem cell therapy market. This is because stem cell therapy can help decrease the after effects of general treatments for burns such as infections, scars, and adhesion. The increasing number of patients suffering from diabetes and growing cases of trauma surgery will fuel the adoption of stem cell therapy in the dermatology segment.

Global Stem Cell Therapy Market: Overview

Also called regenerative medicine, stem cell therapy encourages the reparative response of damaged, diseased, or dysfunctional tissue via the use of stem cells and their derivatives. Replacing the practice of organ transplantations, stem cell therapies have eliminated the dependence on availability of donors. Bone marrow transplant is perhaps the most commonly employed stem cell therapy.

Osteoarthritis, cerebral palsy, heart failure, multiple sclerosis and even hearing loss could be treated using stem cell therapies. Doctors have successfully performed stem cell transplants that significantly aid patients fight cancers such as leukemia and other blood-related diseases.

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Global Stem Cell Therapy Market: Key Trends

The key factors influencing the growth of the global stem cell therapy market are increasing funds in the development of new stem lines, the advent of advanced genomic procedures used in stem cell analysis, and greater emphasis on human embryonic stem cells. As the traditional organ transplantations are associated with limitations such as infection, rejection, and immunosuppression along with high reliance on organ donors, the demand for stem cell therapy is likely to soar. The growing deployment of stem cells in the treatment of wounds and damaged skin, scarring, and grafts is another prominent catalyst of the market.

On the contrary, inadequate infrastructural facilities coupled with ethical issues related to embryonic stem cells might impede the growth of the market. However, the ongoing research for the manipulation of stem cells from cord blood cells, bone marrow, and skin for the treatment of ailments including cardiovascular and diabetes will open up new doors for the advancement of the market.

Global Stem Cell Therapy Market: Market Potential

A number of new studies, research projects, and development of novel therapies have come forth in the global market for stem cell therapy. Several of these treatments are in the pipeline, while many others have received approvals by regulatory bodies.

In March 2017, Belgian biotech company TiGenix announced that its cardiac stem cell therapy, AlloCSC-01 has successfully reached its phase I/II with positive results. Subsequently, it has been approved by the U.S. FDA. If this therapy is well- received by the market, nearly 1.9 million AMI patients could be treated through this stem cell therapy.

Another significant development is the granting of a patent to Israel-based Kadimastem Ltd. for its novel stem-cell based technology to be used in the treatment of multiple sclerosis (MS) and other similar conditions of the nervous system. The companys technology used for producing supporting cells in the central nervous system, taken from human stem cells such as myelin-producing cells is also covered in the patent.

Global Stem Cell Therapy Market: Regional Outlook

The global market for stem cell therapy can be segmented into Asia Pacific, North America, Latin America, Europe, and the Middle East and Africa. North America emerged as the leading regional market, triggered by the rising incidence of chronic health conditions and government support. Europe also displays significant growth potential, as the benefits of this therapy are increasingly acknowledged.

Asia Pacific is slated for maximum growth, thanks to the massive patient pool, bulk of investments in stem cell therapy projects, and the increasing recognition of growth opportunities in countries such as China, Japan, and India by the leading market players.

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Global Stem Cell Therapy Market: Competitive Analysis

Several firms are adopting strategies such as mergers and acquisitions, collaborations, and partnerships, apart from product development with a view to attain a strong foothold in the global market for stem cell therapy.

Some of the major companies operating in the global market for stem cell therapy are RTI Surgical, Inc., MEDIPOST Co., Ltd., Osiris Therapeutics, Inc., NuVasive, Inc., Pharmicell Co., Ltd., Anterogen Co., Ltd., JCR Pharmaceuticals Co., Ltd., and Holostem Terapie Avanzate S.r.l.

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Stem Cell Therapy Market Consumer Outlook 2025 | MEDIPOST Co., Ltd., Osiris Therapeutics, Inc. - Market Research Sheets

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Explained: What is the water crisis Southwest Florida is battling? – Wink News

Posted: December 24, 2019 at 3:49 am

FORT MYERS

Water is Floridas most precious resource. It not only surrounds our state, but it also connects communities within Florida. Floridas unique landscape is made up of wetlands, beaches, swamps, and forests; all of which play a crucial role in the well-being and character of our state. We depend on water for the health of our ecosystems, tourism, economy, and consumption.

Floridas water is now facing its own crisis between quality and quantity. WINK News is devoted to learning about these issues, while explaining what they mean to you and your family. Just as were concerned about the problems, we care about potential solutions. Its all of our water and it will take all hands on deck to get to the bottom of Southwest Floridas water quality crisis.

(Info from SFWMD website https://www.sfwmd.gov/who-we-are/history) To understand our water issues, we have to go back to the beginning. According to the South Florida Water Management District, as recently as the early 1900s, South Floridas inland was swampland.

SFWMD says toward the end of the 19th century, draining led to the connection of waterways, like the Caloosahatchee River to Lake Okeechobee. Following the 1928 hurricane which claimed thousands of lives, the Rivers and Harbors Act of 1930 allows the development of the Herbert Hoover Dike. In the 1960s, the Kissimmee River is straightened out as part of a flood control measure in the state.

These changes reduced water flow to the Florida Everglades, but restoration efforts are underway today.

How does all of this connect to our water quality and quantity concerns? To maintain water levels in Lake Okeechobee, the U.S. Army Corps of Engineers releases water from the lake when necessary. The water flows east and/or west, to the St. Lucie and Caloosahatchee rivers.

SFWMD also controls flooding and protects our water supply through the use of levees, canals and pump stations.

LINK: EPA Nutrient Pollution Sources and Solutions

In regards to water releases from Lake Okeechobee, the concern is harmful nutrients that could end up in our estuaries. These nutrients can stem from fertilizer, septic tanks, stormwater, and fossil fuels. These nutrients, combined with sunlight and slow-moving water, can lead to harmful blue-green algal blooms. Harmful algal blooms like toxic blue-green algae can kill pets and be harmful to humans, resulting in rashes, stomach or liver illness, respiratory issues, and even neurological effects.

LINK: Mote Marine Lab red tide research

Similar to blue-green algae, red tide occurs naturally as a microscopic organism; However, according to Mote Marine Lab, red tide happens when the cells multiply quickly and are paired with things like salinity and temperature. Mote says there is not a direct link between Karenia Brevis, the red tide alga, and nutrient loading, but nutrients can contribute to the growth of red tide. The brevetoxins in red tide are deadly to marine life. When combined with wind and currents, the aerosols from red tide can cause respiratory irritation in people.

Beyond harmful algal blooms, Floridians have to face issues like fecal bacteria in waterways, having too much water as a result of flooding, and not enough water.

This just touches the surface of some of the challenges our water faces. To overcome these problems, people from all walks of life have come together to try to solve them. From agencies to universities and everyone in between, its been an all-hands-on-deck effort to experiment, form task forces, and educate in the light of this crisis.

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Explained: What is the water crisis Southwest Florida is battling? - Wink News

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Healing Dose of Optimism: The Top 10 Medical Breakthroughs of 2019 Will Have You Cheering – Good News Network

Posted: December 24, 2019 at 3:47 am

From zeroing in on different cancer cures to restoring vision and hearing to the blind and deaf2019 was a year filled with medical breakthroughs.

While some of these accomplishments may be varied in their stages of research, each notable study is just one more milestone towards treating some of humanitys most debilitating conditions.

So without any further ado, lets give it up for the top ten health and medical breakthroughs of 2019.

An exciting study that was published back in January found that exposure to blue light is an effective, non-pharmaceutical treatment for high blood pressure, which simultaneously reduces the risk of developing cardiovascular disease.

The researchers who conducted the study from the University of Surrey and Heinrich Heine University Duesseldorf discovered that exposure to whole-body blue light significantly reduced the systolic blood pressure of participants by almost 8 mmHg, compared to the control light which had no impact.

Whats even more remarkable is that the reduction of blood pressure from blue light is similar to what is seen in clinical trials with blood pressure lowering drugs.

Rather than targeting the typical rogue proteins associated with dementia, scientists found earlier this month thatfor the very first timethey have reversed dementia in mice with a drug that reduces inflammation.

Up until now, most dementia treatments have targeted the amyloid plaques that are found in people with Alzheimers disease. However, experiments conducted at the University of California, Berkeley suggest targeting inflammation in the brain might stop it in its tracks.

If you didnt already have enough reason to eat your vegetables, this study published back in May says that broccoli contains an amazing ingredient which could be the Achilles heel of cancer.

Broccoli is part of the cruciferous vegetable family, which includes cauliflower, cabbage, kale and Brussels sproutsand though many people dont like their taste, these vegetables contain a tiny, but powerful molecule that deactivates the gene responsible for cancerous tumor growth, known as WWP1.

Millions of blind people could have their vision restored using stem cells taken from the eyes of non-living donors, according to Scottish research publish back in March.

Thanks to the pioneering tissue transplant, eight patients with a common condition that destroys vision had the affected area repairedand two patients were even able to read again after having severe macular degeneration.

Back in April, Canadian researchers developed a new treatment for mobility-impaired Parkinsons disease patientsand the results were beyond their wildest dreams.

Scientists from Western University in Ontario published the results of a pilot study in which they used spinal implants to improve motor function in several patients with advanced Parkinsons.

Prior to the study, the patients were barely able to stand on their own without falling over or they were forced to depend entirely on wheelchairs for mobility. After getting the spinal implant, however, the patients are now capable of walking unassisted for the first time in years.

According to a report from May, people who experience anxiety symptoms might be helped by taking steps to regulate the microorganisms in their gut using probiotic and non-probiotic food and supplements.

Anxiety symptoms are common in people with mental diseases and a variety of physical disorders, especially in disorders that are related to stress. Previous studies have shown that as many as a third of people will be affected by anxiety symptoms during their lifetime.

Increasingly, research has indicated that gut microbiotathe trillions of microorganisms in the gut which perform important functions in the immune system and metabolism by providing essential inflammatory mediators, nutrients and vitaminscan help regulate brain function through something called the gut-brain axis.

In August, researchers at Johns Hopkins Medicine may have found the key to restoring hearing in people with irreversible deafness.

Using genetic tools in mice, researchers at Johns Hopkins Medicine say they identified a pair of proteins that precisely control when sound-detecting cells, known as hair cells, are born in the mammalian inner ear.

Scientists in our field have long been looking for the molecular signals that trigger the formation of the hair cells that sense and transmit sound, says Dr. Angelika Doetzlhofer, associate professor of neuroscience at the Johns Hopkins University School of Medicine. These hair cells are a major player in hearing loss, and knowing more about how they develop will help us figure out ways to replace hair cells that are damaged.

As MDMA is now being recognized as a groundbreaking cure for emotional trauma, a new clinic in Pennsylvania could become one of the first legally-sanctioned facilities for using the psychoactive drug on treatment-resistant PTSD in the United States.

Now that it has reportedly opened its doors in Wyndmoore, The Landing medical facility will specialize in using several psychoactive drugs to treat a variety of mental health disorders.

Particularly, it has been pushing to receive FDA approval on using MDMA-assisted psychotherapy for patients whose Post-Traumatic Stress Disorder has been untreatable.

Dental fillings may soon be a thing of the past, thanks to this breakthrough from Chinese scientists.

Enamel is the mineralized substance that protects the surface of teeth. Though it is one of the toughest tissues in our bodies, it is prone to degradation over time particularly as a result of consistent exposure to certain acids that are found in food and drinks.

We currently use resins and ceramics to fill in deteriorated enamel, but these fillings can often become loose within just a few years of their placementand with tooth decay being one of the most prevalent chronic diseases amongst humans, scientists have puzzled over how they can recreate enamel.

Until now, we have not been able to reproduce the toughened tissue because of its complex cellular structurebut back in September, a team of researchers from Zhejiang University School of Medicine developed a gel that makes enamel repair itself.

With pancreatic cancer ranking as one of the most deadly forms of cancer, researchers were excited to report on a promising new breakthrough for a treatment.

Pancreatic cancer, which maintains a 95% mortality rate, is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosedand since the disease does not show symptoms until the advanced stages, it is notoriously hard to diagnose.

However, this Tel Aviv University study published earlier this month finds that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells. The research was conducted with xenograftstransplantations of human pancreatic cancer into immunocompromised mice. The treatment reduced the number of cancer cells by 90% in the developed tumors a month after being administered.

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The top 10 science stories of 2019 | NOVA – NOVA Next

Posted: December 24, 2019 at 3:44 am

1. New Horizons nails the most distant flyby in history

Just 33 minutes after ringing in the New Year, scientists at the Johns Hopkins University Applied Physics Laboratory cheered and threw confetti a second time. The New Horizons spacecraft had just conducted a flyby of a Kuiper Belt object 4 billion miles from Earth. And as the sun rose on January 1, New Horizons beamed back its first close-up images of the 19-mile-long peanut-shaped space rock, officially named 2014 MU69.

Images eventually revealed 2014 MU69 (initially nicknamed Ultima Thule), to be a surprisingly flat contact binary, a body composed of two once-separated rocks that slowly gravitated toward each other until they lightly touched and fused. Scientists believe the flyby data could offer insight into how planets formed in our solar system billions of years ago.

In November, NASA changed the rocks nickname from Ultima Thule, a term with links to the Nazi party, to Arrokoth, which means sky in the Powhatan/Algonquian language.

2014 MU69 is revealed to be a two-tiered snowman. According to the New Horizons team, this image supports the idea that planets in our system formed as bits of raw planetary matter coalesced over time. Image Credit: NASA/Johns Hopkins University Applied Physics Laboratory/Southwest Research Institute

Twelve years after a first patient was declared to be rid of HIV, another person achieved a similar milestone this year. In March, with the help of a stem cell transplant from a virus-resistant donor, the anonymous individual entered long-term remission from HIV.

In both cases, remission followed a transplant of bone marrow from a person with a mutation in the gene that encodes the protein CCR5, which many HIV strains use to infiltrate cells. Neither treatment was originally intended to eliminate the infection itself, but to treat blood cancers that had spread in both individuals.

While the intervention is likely to be effective in only a small fraction of HIV-positive individuals, the 2019 case shows that its efficacy was more than a one-time event.

In April, we were able to feast our eyes on the first-ever image of a black hole. The black hole, whose image was generated from data captured by a network of eight radio observatories that make up the Event Horizon Telescope, dwells in the center of a galaxy some 55 million light-years away from Earth.

As popular as the black hole image was, another aspect of the story that quickly unfolded online: the contribution of 29-year-old MIT scientist Katie Bouman, who crafted an algorithm to help translate the telescope data into the black hole image. Bouman, captured in a photo with a laptop, beaming behind her folded hands, quickly became a symbol for womens accomplishment in astronomy and computer science. But, Marina Koren writes for The Atlantic, This one image tapped into a multitude of questions about the role of women in science, the myth of the lone genius, and the pressure scientists have to promote themselves and their work on social media.

No one algorithm or person made this image, Bouman later wrote, referring to the black hole picture, in a Facebook post. It required the amazing talent of a team of scientists from around the globe and years of hard work to develop the instrument, data processing, imaging methods, and analysis techniques that were necessary to pull off this seemingly impossible feat.

CRISPR-Cas9 is a tool that lets scientists cut and insert small pieces of DNA at precise areas along a DNA strand. | Photo credit: Public Domain

In April, researchers began the first CRISPR-Cas9 gene-editing clinical trials in people in the United States. In the trials, scientists used CRISPR, a powerful gene-editing technique derived from an ancient bacterial immune system, to combat cancer and blood disorders. That month, two cancer patientsone with myeloma and one with sarcomawere treated using CRISPR.

In the cancer and blood disorder trials, researchers remove some cells from a patients body, edit the cells DNA using CRISPR, and inject the cells back in, now hopefully armed to fight disease, Tina Hesman Saey writes for Science News. But in another trial, conducted by Editas Medicine in Cambridge, Mass., researchers are using CRISPR to edit DNA directly in the human body by snipping a small piece of DNA out of cells in the eyes of people with an inherited form of blindness, Saey writes.

The trials come on the heels of Chinese scientist He Jiankuis gene-editing on twin girls born in November 2018, which was widely criticized as premature and highly unethical. .

Mammal fossils like this one, discovered by a team of paleontologists and paleobotanists led by Tyler Lyson in Corral Bluffs, Colorado, fill in a missing piece of the timeline of life. Image Credit: HHMI Tangled Bank Studios

This year, scientists gleaned new insight into the day the dinosaur-killing asteroid crashed into Earth 66 million years ago, and the first million years after the impact.

In April, paleontologist and graduate student Robert DePalma claimed to unveil an unprecedented time capsule of the asteroid-induced catastrophe. He reported finding scorched tree trunks and hundreds of well-preserved fossil fish beneath sediment at a site in North Dakota, forming a snapshot of the first minutes and hours after impact. (Some experts remain cautious about the finding, due in part to the fact that DePalmas discovery was first announced in a New Yorker article before publication of the peer-reviewed paper.)

Then, in October, new fossils that capture the million-year timeline of life after the dinosaurs died were revealed. Discovered in Colorados Corral Bluffs by paleontologist Tyler Lyson and his team, the fossils showcase the extraordinary resilience of life in the wake of disaster and help reveal the evolutionary journey of the mammals that survived the asteroid.

With the use of artificial intelligence on the rise, one serious flaw continued to make headlines in 2019: racial bias. In October, researchers announced that a particular algorithm, which predicts who might benefit from follow-up care and affects 100 million Americans, underestimates black patients need for additional treatment. The algorithm underestimates the health needs of black patients even when theyre sicker than their white counterparts.

Additionally, the U.S. remains one of the most dangerous developed nations in which to be pregnant and give birth, particularly for minorities. Pregnancy-related deaths are rising in the United States and the main risk factor is being black, Mike Stobbe and Marilynn Marchione write for AP News. A CDC report concludes black women, along with Native Americans and Alaska natives, are three times more likely to die before, during or after having a baby, and more than half of these deaths are preventable, Stobbe and Marchione write.

Also this year, researchers further investigated why black scientists are less likely to receive funding from the National Institutes of Health (NIH) than their white counterparts. A study published in October illustrated that topic choice contributes to the lower rates of NIH awards going to black scientists. Specifically, Jeffrey Mervis writes for Science Magazine, black applicants are more likely to propose approaches, such as community interventions, and topics, such as health disparities, adolescent health, and fertility, that receive less competitive scores from reviewers.

A replica of a fragment of a Denisovan finger found in Denisova Cave, Siberia, in 2008. Image Credit: Thilo Parg, Wikimedia Commons

New findings in 2019 added to anthropologists understanding of Denisovans, a species of early human that likely shared the planet with Homo sapiens as recently as 50,000 years ago.

This fall, scientists learned that although Denisovans DNA ties them more closely to Neanderthals, their fingers may have looked more like ours, suggesting Neanderthals broader digits evolved after their lineage split off from the Denisovans around 410,000 years ago. A few more fossils, Bruce Bower writes for Science News, plus genetic analyses indicated Denisovans were close relatives and occasional mating partners of Neanderthals and Homo sapiens tens of thousands of years ago. But there was too little evidence to say what Denisovans looked like or how they behaved.

Physicists reached a milestone in quantum computing this year, a method of computing that uses quantum physics to solve complex problems quickly.

In October, Google said it had achieved quantum supremacy. Its AI Quantum Team presented evidence that it had built a quantum computer that needs only 200 seconds to solve a problem that would have taken IBMs Summit, the worlds most powerful supercomputer, 10,000 years to crack. Though IBM disputed the claim, others in the computing community are tentatively optimistic about the breakthroughs promise. If validated, it may bring us closer to a future of ultra-efficient computing.

Just when you thought Saturn couldnt get any more awesome, it secured yet another claim to fame: the most known moons of any planet in our solar system (sorry, Jupiter).

On October 7, the International Astronomical Unions Minor Planet Center announced that researchers discovered an additional 20 moons orbiting Saturn, bringing its grand total to a whopping 82. Jupiter, the largest and oldest planet in our solar system, has 79.

The latest discoveries were made possible by Hawaiis Subaru telescope. A team led by Carnegie Sciences Scott S. Sheppard first eyed them in the spring of 2017, but because faraway moons are dim and tough to spot, researchers used Subaru to scan the skies periodically throughout the following years to confirm their finding. Then, they used a computer algorithm to link the data through time and confirm that the moons were indeed reliably orbiting Saturn.

Less than a week after the U.N. climate talks came to a close in Madrid this month, Australia recorded its hottest day ever, one day after its previous record. Just a few months ago, wildfires raged across not only the American West and Australian Outback but also Europe and the Amazon, an occurrence that many climatologists believe may have been exacerbated by climate change-induced drought and high temperatures. And in May, a United Nations report claimed that one million plant and animal species are on the verge of extinctionmore than in any other period in human historywith alarming implications for human survival. The warming climate, which heightens the effects of overfishing, pesticide use, pollution, and urban expansion is a major driver, the report concludes.

Three weeks ago, a bleak climate report, also from the U.N., predicted that global carbon emissions will climb despite promises from almost 200 nations to address climate change, propelling temperatures upward and threatening to shatter the threshold of 2C that scientists say would invite dramatic changes to ecology and the economy, Nathaniel Gronewald writes for Science Magazine. And many declared this months COP25 climate talks to be a massive failure.

But climate activists, particularly teens, have seized the spotlight this year. Greta Thunberg, a 16-year-old Swedish climate activist, was just named TIMEs Person of the Year. And at COP25, official youth constituency representatives expressed their disappointment to leaders and officials, Kartik Chandramouli writes for Mongabay. Do you want to be remembered as the ones who had the chance to act but decided not to as betrayers of our generation, of indigenous people and communities desperately fighting on the ground? Youth representatives said. We are rising, we are fighting and we will win.

Excerpt from:
The top 10 science stories of 2019 | NOVA - NOVA Next

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Mums plea for stem cell donor to treat her cancer after her ex killed teen son who could have been a match – The Sun

Posted: December 23, 2019 at 9:46 am

A MUM is pleading for a stem cell donor to treat her cancer after her ex killed her teenage son - who may have been her only match.

Tania Morris, 49, was left battered and bruised by former lover Robert Goodwin in a row over fast food last year.

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The monster went on to bludgeon her 19-year-old son Nathan Bates to death while on bail for the attack, before killing himself.

In the latest horror twist, Tania now fears this Christmas could be her last after she was diagnosed with Hodgkin's Lymphoma shortly after burying her only child.

Tania's rare tissue type means there is no one on the entire global register who provides a match.

The pottery worker from Burslem told StokeonTrentLive: "It's heartbreaking. The doctors just keep saying we need a fit and healthy 19-year-old and that breaks my heart as that's how old Nathan was when he was murdered.

"My younger brother could have been a match but he died of a heart attack.

"My other brother Darren was devastated when he was tested and wasn't a match. He wanted so much to help me.

"Dad's only a half match. He's too poorly himself to go ahead but if and when it becomes life or death he could be a last resort. They're worried it would kill both me and him.

"It would really be desperate measures if it comes to that. It would be my last option because it could kill me.

"My mum's not even been tested because she's had a heart bypass.

"We are just hoping that someone comes forward. It's my only chance of beating this."

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Tania was left with horrific injuries in August 2018, when sick Goodwin tried to gauge out her eye before smashing a porcelain doll ornament over her face.

Months later he killed Nathan with a hammer as he slept before killing himself in nearby woodland on October 11 last year.

Tania is still unclear what motivated the murder - that may indirectly lead to her death as well.

The doctors just keep saying we need a fit and healthy 19-year-old and that breaks my heart as that's how old Nathan was when he was murdered.

Goodwin had been due in court the day after Nathans killing to face the assault charge against Tania - but will now never face justice for either offence.

Since her diagnosis in January, Tania has gone through multiple rounds of chemotherapy, but has now been told that the treatment hasn't worked.

She is calling on any young donor to come forward in what she thinks could be her only shot at living.

"I haven't properly grieved for Nathan because of the cancer," she said.

"He just couldn't cope with the thought of going to prison so he killed Nathan, killed himself and if I don't find a donor, he may yet kill me. All the stress he's put our family through also led to my mum's heart attack.

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"He had no reason to do what he did, he just wanted to upset me in the worst possible way.

"He said he loved me to pieces but then he did this."

Anyone who is healthy and aged 16-30 can donate stem cells by signing up with the Anthony Nolan register here.

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Mums plea for stem cell donor to treat her cancer after her ex killed teen son who could have been a match - The Sun

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Global Allogeneic Stem Cells Market 2020-2024 | Evolving Opportunities with Biosolution Co. Ltd. and Cynata Therapeutics Ltd. | Technavio – Yahoo…

Posted: December 23, 2019 at 9:46 am

Technavio has been monitoring the global allogeneic stem cells market and the market is poised to grow by USD 1.24 billion during 2020-2024 at a CAGR of over 12% during the forecast period. Request Free Sample Pages

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20191218005455/en/

Technavio has announced its latest market research report titled global allogeneic stem cells market 2020-2024. (Graphic: Business Wire)

Read the 131-page research report with TOC on "Allogeneic Stem Cells Market Analysis Report by geography (Asia, Europe, North America, and ROW), by application (regenerative therapy and drug discovery and development), and segment forecasts, 2020-2024".

https://www.technavio.com/report/allogeneic-stem-cells-market-industry-analysis

The new product approvals and special drug designations are anticipated to boost the growth of the market. Based on the application, the allogeneic stem cells market has been segmented into regenerative therapy and drug discovery and development. Manufacturers are increasingly emphasizing innovations and improvisation in the development of regenerative therapies. Many of the regenerative therapeutic candidates have obtained approval for clinical trials in the US, Europe, and APAC due to the efficacy of allogeneic stem cell therapeutics. This is encouraging market players to launch new product lines to stimulate the overall product demand for stem or regenerative therapy using allogeneic stem cell therapeutics and provide better options for their customers. Thus, new product approvals are expected to drive market growth during the forecast period.

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Major Five Allogeneic Stem Cells Market Companies:

Biosolution Co. Ltd.

Biosolution Co. Ltd. is headquartered in South Korea (Republic of Korea) and operates the business under its Unified business segment. The company offers an allogeneic keratinocyte spread medication, Keraheal-Allo, that promotes skin regeneration.

Cynata Therapeutics Ltd.

Cynata Therapeutics Ltd. is engaged in the discovery, development, licensing, manufacturing, marketing, distribution, and sales of innovative therapeutics for the treatment of various diseases. The company provides a mesenchymal stem cell product, Cymerus, which is used to treat graft-versus-host disease.

JCR Pharmaceuticals Co. Ltd.

JCR Pharmaceuticals Co. Ltd. is headquartered in Japan and operates under two business segments, namely Pharmaceuticals, and Medical Devices and Laboratory Equipment. The company offers a regenerative medical product, TEMCELL HS Injection, which uses human mesenchymal stem cells for the treatment of acute graft-versus-host disease.

Lineage Cell Therapeutics Inc.

Lineage Cell Therapeutics Inc. is headquartered in the US and offers products through its Unified business segment. The company provides OpRegen, which is currently being tested in a Phase I/IIa clinical trial. This product is intended for the treatment of dry AMD.

MEDIPOST Co. Ltd.

MEDIPOST Co. Ltd. is headquartered in South Korea (Republic of Korea) and offers products through its Unified business segment. The company provides an allogeneic umbilical cord blood-derived mesenchymal stem cell drug, CARTISTEM, which is used for the treatment of knee cartilage defects.

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Allogeneic Stem Cells Application Outlook (Revenue, USD Million, 2020-2024)

Allogeneic Stem Cells Regional Outlook (Revenue, USD Million, 2020-2024)

Technavios sample reports are free of charge and contain multiple sections of the report, such as the market size and forecast, drivers, challenges, trends, and more. Request a free sample report

Related Reports on Health Care include:

Cancer Stem Cell Therapeutics Market Global Cancer Stem Cell Therapeutics Market by type (allogeneic stem cell transplant and autologous stem cell transplant) and geography (Asia, Europe, North America, and ROW).

About Technavio

Technavio is a leading global technology research and advisory company. Their research and analysis focus on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions.

With over 500 specialized analysts, Technavios report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavios comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

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Global Allogeneic Stem Cells Market 2020-2024 | Evolving Opportunities with Biosolution Co. Ltd. and Cynata Therapeutics Ltd. | Technavio - Yahoo...

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