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Keros Therapeutics Reports Recent Business Highlights and Fourth Quarter and Full Year 2022 Financial Results

Posted: March 4, 2023 at 12:14 am

LEXINGTON, Mass., March 03, 2023 (GLOBE NEWSWIRE) -- Keros Therapeutics, Inc. (“Keros” or the “Company”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel treatments for patients suffering from hematological, pulmonary and cardiovascular disorders with high unmet medical need, today provided a business update and reported financial results for the fourth quarter and full year ended December 31, 2022.

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Fate Therapeutics to Present at Upcoming March Investor Conferences

Posted: March 4, 2023 at 12:14 am

SAN DIEGO, March 03, 2023 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (the “Company” or “Fate Therapeutics”) (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to bringing a first-in-class pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients with cancer and autoimmune disorders, today announced that the Company will participate in the following upcoming investor conferences:

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Impel Pharmaceuticals to Participate in Upcoming Investor Conferences in March

Posted: March 4, 2023 at 12:14 am

SEATTLE, March 03, 2023 (GLOBE NEWSWIRE) -- Impel Pharmaceuticals Inc. (NASDAQ: IMPL), a commercial-stage pharmaceutical company developing transformative therapies for people suffering from diseases with high unmet medical needs, today announced that the Company will participate in two upcoming investor conferences in March:

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Praxis Precision Medicines to Present at Upcoming Investor Conferences

Posted: March 4, 2023 at 12:14 am

BOSTON, March 03, 2023 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ: PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that management will participate in the following upcoming investor conferences:

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Mersana Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

Posted: March 4, 2023 at 12:14 am

CAMBRIDGE, Mass., March 03, 2023 (GLOBE NEWSWIRE) -- Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today announced that on March 1, 2023, an authorized sub-committee of the Board of Directors of Mersana granted inducement awards, consisting of restricted stock unit awards (RSUs) to acquire an aggregate of 44,930 shares of its common stock, to four new employees whose employment commenced in February 2023. The awards were granted pursuant to terms and conditions fixed by the Compensation Committee and as an inducement material to each new employee entering employment with Mersana in accordance with Nasdaq Listing Rule 5635(c)(4).

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22nd Century Group (XXII) Secures $21 Million Debt Financing to Expand Working Capital for Growth Initiatives

Posted: March 4, 2023 at 12:14 am

Supports Accelerated Expansion of VLN Multi-State Retail Channels, GVB Global Ingredients and CDMO Business Supports Accelerated Expansion of VLN Multi-State Retail Channels, GVB Global Ingredients and CDMO Business

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MDxHealth Shareholder Transparency Declarations

Posted: March 4, 2023 at 12:14 am

NEWS RELEASE – REGULATED INFORMATION MARCH 3, 2023, 4:30 pm ET/ 22:30 CET

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Kane Biotech Clarifies Terms of Credit Facility

Posted: March 4, 2023 at 12:14 am

Not for distribution to U.S. news wire services or dissemination in the United States

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Heart disease study shows hope for stem cell treatment

Posted: March 4, 2023 at 12:10 am

Researchers have tried for decades to use stem cells to restore a damaged heart.

A new study shows they still haven't succeeded, but it offers the first glimmers of hope for heartdisease, whichis blamed for about 1 in 5 deaths in the United States, killingnearly 700,000 people a year.

The trial, by the Texas Heart Institute, showed that a one-time treatment of cells didn't keep heart failurepatients out of the hospital. But it dramatically reduced the risk of stroke or recurrent heart attack for the nearly three years of the study, particularly among people who also had high levels of inflammation.

"At a year, the hearts were pumping stronger," said Dr. Emerson Perin, who led the research.

While he will have to conduct another clinical trial before winning approval for his approach, he has a path forward, Perin said.

"I now have the recipe," he said. "I know who I have to give (the cells) to, how I have to give them and in what dose."

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Stem cells are cellsthat can turn into a variety of other cells.

Every person arises from the combination of an egg and a sperm. Once fused, this combination of cells divides repeatedly, leadingto every other cell in the body, from brain to gut cells.

Early cells with the ability to become every other cell are called "embryonic stem cells."

The human bodyalso produces stem cells later in development that are less versatile than embryonic ones, but still may be useful in medicine. So-called mesenchymal stem cells can turn intobone, cartilage, muscle and fat.

In this study, researchers used precursor mesenchymal stem cells taken from three young, adult donorswithout heart disease. The goal was to alter the environment around the patients'hearts to decrease inflammation.

In the study of 565 heart failure patients from 52 treatment centers, half were given high doses of these mesenchymal stem cells and the other half a sham procedure.

The study was designed to measure hospitalization and time until death, neither of which were statistically improved by the treatment.

But those who received the cells had a 58% reduced risk of heart attack or stroke, and among patients with high levels of inflammation the risk reduction rose to 75%.

These patients were already heavily treated with medication, so the improvements came on top of those therapies.

For years, Perin said, he's been seeing patients with heart failure get better when he gave them mesenchymal stem cells.

"Until now we didn't know why," Perin said. "Cell therapy has been this black hole. ... We now have insights into how it works."

Dr. Richard Lee, a stem cell biologist at Harvard University, said he found the study usefulbut thinks this type of stem cell has a long way to go to becomea treatment for heart failure.

Drugs already available to treat heart failure are underused, he said, and doctors shouldn't wait around for newer therapies. "We should be doing better now," Leesaid.

Despite these other therapies, heart failure continues to be a major problem for patients, saidDr. Roberto Bolli, who holds the distinguished chair in cardiology at the Jewish Hospital Heart and Lung Institute in Louisville, Kentucky.

"We can improve the symptoms of these patients, but still, their long-term outcome is not good. They will inexorably get worse and worse over time," said Bolli, who was not involved in the new research.

Also, the new study showed that the treatment was safe. None of the patients in this trial or in others over the years have suffered serious problems after receiving stem cells for heart disease.

This is first large study of stem cell therapy in heart disease to show an improvement for patients, Bolli said."That's very significant."

Four other smaller trialshave also shown promise in heart failure, including one he led, co-authored by Perin.

"I would say cell therapy is a promising treatment for chronic heart failure," Bolli said.

Researchers have been working for decades to get stem cells to benefit heart disease patients.

Dr. Joshua Hare, a cardiologist at the University of Miami who does stem cell research but was not involved in the current study, said he thinks the field would have moved faster if it had been better funded.

He hopes the new finding, though technically a failure, will encourage more investment.

Stem cell clinics, which "steal people's money" for procedures that don't help cardiac patients, havealso created problems for the field, said Dr. Timothy Henry, a cardiologist and director of the Lindner Center at Christ Hospital inCincinnati, Ohio.

Bolli said research has been so slow in partbecause itfocused for 15 years on treating patients after heart attacks, hoping the cells would rebuild a damaged heart when given within a few days. At least 10 trials have shown that doesn't work.

Instead,the new trialand the four smaller ones suggest that stem cells are best at helping patients with long-standingheart failure, by reducing inflammation around the heart, which continues to damage its function.

Bolli said the new findings strongly suggest the need for a follow-up study concentrating on patients who also have inflammation. (Henry, who was on the steering committee for the new study, said he is optimistic thatMesoblast, the Australian company that funded the trial, will go forward with another study.)

"If that trial confirms these results, that will be a major advance in cardiovascular medicine," Bolli said. "We don't know of any other treatment that does that."

Contact Karen Weintraub at kweintraub@usatoday.com.

Health and patient safety coverage at USA TODAY is made possible in part by a grant from the Masimo Foundation for Ethics, Innovation and Competition in Healthcare. The Masimo Foundation does not provide editorial input.

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Focus On Stem Cell Research | National Institute of Neurological …

Posted: March 4, 2023 at 12:10 am

Stem cells possess the unique ability to differentiate into many distinct cell types in the body, including brain cells, but they also retain the ability to produce more stem cells, a process termed self-renewal. There are multiple types of stem cell, such as embryonic stem (ES) cells, induced pluripotent stem (iPS) cells, and adult or somatic stem cells. While various types of stem cells share similar properties there are differences as well. For example, ES cells and iPS cells are able to differentiate into any type of cell, whereas adult stem cells are more restricted in their potential. The promise of all stem cells for use in future therapies is exciting, but significant technical hurdles remain that will only be overcome through years of intensive research.

NINDS supports a diverse array of research on stem cells, from studies of the basic biology of stem cells in the developing and adult mammalian brain, to studies focusing on nervous system disorders such as ALS or spinal cord injury. Other examples of NINDS funded research include using iPS cells to derive dopamine-producing neurons that might alleviate symptoms in patients with Parkinsons disease, and using ES cells to generate cerebral organoids to model Zika virus infection.

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