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The Study Of Anesthesiology And Tips From Dr. Halim – Yahoo Finance

Posted: December 11, 2019 at 2:41 am

Anesthesiologists are trained to safely administer anesthetics to induce a temporary loss of sensation or consciousness for the performance of a medical procedure. This involves a variety of medical drugs ranging from local numbing agents to general anesthesia.

Anesthesiologists are an integral part of the surgical team since their role involves patient preoperative clearance, intraoperative care as well as post-operative recovery.

Dr. Halims medical training began at Northwestern University in Chicago. Dr. Halim did a research fellowship in pharmacokinetics and pharmacodynamics before she went on to perform her internship in internal medicine. Dr. Halim did her residency in anesthesiology, along with subspecialty training in critical care/trauma and pediatrics at Northwestern University.

The core function of anesthesiology is the practice of anesthesia. This involves the use of topical, injected, or inhaled medications to produce a loss of sensation. Without anesthesia, many surgical and non-surgical procedures would be intolerable or unfeasible, says Dr. Halim.

Anesthesiologists are the internist in the operating room as well as procedure oriented therefore must be knowledgeable in all areas of medicine and surgery, understanding anatomy and pathophysiology in order to provide proper care in any situation.

As an anesthesiologist, she has worked with physicians and surgeons in virtually every specialty. She has continued to build up her expertise in other areas of medicine such as integrative medicine, post-traumatic stress disorder, traumatic brain injury, and cognitive decline therapies including hyperbaric therapy protocols.

Dr. Halim is constantly researching, learning and training to remain on the cutting edge of medicine and combining traditional medicine with functional medicine.

Anesthesiologists must receive their board certification through the American Board of Anesthesiology, which demonstrates advanced skill and knowledge.

Image by Anne Karakash from Pixabay

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MedLife purchases the full block of shares of OncoCard Brasov Hospital – Business Review

Posted: December 11, 2019 at 2:41 am

Founded in 2012, OncoCard is one of the most modern oncologic hospitals in Romania, based on an innovative concept of Integrative Medicine which starts during the diagnosis stage of the patient and covers the whole specific active treatment period. The institution includes ambulatory care, an oncological surgery unit, departments for hematology, radiotherapy, and medical imaging, and also its own medical lab used for admitted patients. Since opening, OncoCard Brasov received EUR 24 million worth of investments, the hospital recording a turnover of LEI 41.8 million in 2018.

This partnership comes from our strategy to expand and develop the oncologic sector and we are glad to have such a great team of experts besides us, which will strengthen the medical excellency zone even further. OncoCard comes to complete the oncologic services provided by us in the surgery units of all MedLife hospitals, and will become the first integrated oncologic centre in Brasov, and the second in our group, after Sibiu. For us, its an area of interest and we dont rule out consistent investments over the next few years in oncologic treatment of excellence on a national level. Declared Mihai Marcu, President and CEO of MedLife.

The transaction will be analyzed by the Romanian Competition Council, and once approved could become the most important piece of business for the MedLife group in 2019.

We have always advocated for excellency in healthcare, imposing on ourselves to become a landmark of quality for the level of medical services offered, managing to instill trust and courage in our patients. Said Raluca Buzea, OncoCard Brasov shareholder.

By taking over OncoCard Brasov, MedLife group have reached a portfolio of 27 successful acquisitions, the most recently announced one being that of Micromedica Medical Centre.

Photo: OncoCard.ro

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Cancer in the workplace: Innovative diagnostic devices and treatments – Bangkok Post

Posted: December 11, 2019 at 2:41 am

Cancer itself is a very broad based topic. There are various forms of cancer and many different types of diagnostics and treatments that are currently available. In our earlier articles, we have touched on various aspects of cancer:

- Key facts with statistics - Major causes- The correlation between employment and the illness- Risk reduction- Types of treatment available- Treatment cost overview- Integrative and Preventive Medicine

So far, the treatment model that is proven by several sources to have the best results is through Integrative Medicine. Its approach is to combine conventional methods with both complementary and alternative therapies. It is very patient-centred, making use of natural products, modification of lifestyle, diet, a mind-body-spirit healing journey together with conventional treatments like chemotherapy.

Dr. ChatChai Sribundit (M.D) from Akesis Life Bangkok (akesisoncology.com) emphasises the important role that integrative medicine plays in todays cancer management and in many cancer-care programs. As he mentioned in earlier articles, almost one third of cancer cases are actually preventable. Risk factors can be eliminated and implementing existing evidence-based preventive strategies are definitely the winning formula.

In the long run, preventive strategies in the form of regular exercise and maintaining a healthy weight reduces the risk not only of cancer but many other primary medical conditions. In addition, a well-balanced lifestyle and healthy food provide both long and short term benefits. Apart from the above, Dr. Chatchai stands firmly by his 5 pillars consisting of medical intervention, diet & nutrition, physical therapy & exercise, emotional wellness and patient education.

Together with the basis of the 5 Pillars, early detection with timely and proper patient management can greatly reduce cancer risk. Many cancers have a high chance of cure if diagnosed early and treated adequately.

Chemotherapy and radiotherapy remain a mainstream form of treatment whereas tissue biopsy and scans are general diagnostic tools commonly used in Conventional therapies for cancer. In some cases, a targeted approach is lacking and patients can be vulnerable to certain types of drugs. Recently, new treatments have been emerging to improve the traditional options in cancer treatment with poor prognosis. Areas like nanomedicine and extracellular vesicles along with advances in immunotherapy and nanotechnology are becoming a norm for the next generation of cancer diagnosis and treatments.

Liquid Biopsy

Molecular targeting of specific oncogenic mutations in human cancer is now key for anti-cancer drug therapy as mutations lead to drug resistance. Therefore, the ability to detect and continuously monitor oncogenic mutations is important as it guides the use of targeted molecular therapies to improve long-term clinical outcomes in patients. Apart from direct sampling of cancer tissue by biopsy, oncogenic mutations are also detectable in circulating bodily fluids of patients which is a less invasive method.

Cancer biomarker discovery using DNA aptamersBiomarkers are molecules able to indicate specific physiological states of cells. Identifying reliable biomarkers is essential for early diagnosis and adaptive treatment strategies. According to pub.vsc.org, aptamers are single-stranded oligonucleotides generated by an in vitro screening method called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). They can recognise their cognate targets with selectivity and affinity comparable to protein antibodies in cancer patients.

Nanomedicine

Treating cancer with nanotechnology has become one of the emerging trends. Studies reveal that treating cancer by nanoparticle enhances the efficiency of the treatment and also minimises adverse effects. The property of nanoparticles in treating cancer is target specific. Nanoparticles also target uncontrolled cell proliferation.

Extracellular vesicles (EVs) are released by all cells within the tumour microenvironment, such as endothelial cells, tumour-associated fibroblasts, pericytes, and immune system cells. The EVs carry the load of parental cells formed of proteins and nucleic acids, that convey cell-to-cell communication and also suppress tumour progression. Due to longevity of vesicles within the circulation and their ability to cross bloodbrain barriers, modification of these unique organelles offers the potential to create new biological-tools for cancer therapy.

These treatments help ones immune system to find and attack cancer cells the same way it attacks bacteria and viruses. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by maximising the immune system to prevent or slow down the growth of cancer and reduce the probability of spreading. Some examples of immunotherapy, include, NK Cell therapy, Cancer vaccines (prophylactic or therapeutic) and T-cell therapy.

Commonly use in Integrative medicine and in conjunction with radiation, hyperthermia is a non-invasive method of increasing tumour temperature to stimulate blood flow and improve oxygenation. This makes cancer cells more sensitive during radiation therapy. Hyperthermia helps address the limitations of radiation for many patients by effectively increasing the radiation dose without increasing in unwanted side effects. There are significant results which show the effect of hyperthermia approach in treating cancer.

Longdom.org states that this treatment uses a drug called photosensitizer or photosensitizing agents. Agents and particular type of light are exposed at a specific wavelength. The specificity of wavelength depends on the production of oxygen. Oxygen destroys nearby Cancer cells. The wave length determines the distance travelled by the light into the body. The photosensitizer present in a tumour absorbs the light and produces oxygen which destroys surrounding cancer cells.

This treatment uses light amplification by the stimulated emission of radiation. Laser therapy for treating cancer includes special light beams instead of instruments. Laser therapy is normally given through an endoscopic tube. There are different types of laser therapies used for treatment of cancer. The Endoscope is inserted in the body to treat cancer or precancerous growth. Lasers can also be used to shrink or destroy tumours or precancerous growth.

The initial stage, which is most important, is the detection of cancer. Early detection could increase the possibility of cure and increases survival rates. However, poor prognosis due to lack of proper diagnosing methods and ineffective chemotherapeutic treatment is a common hurdle. As synthetic drugs cause many side effects, and cancer cells become resistant, more innovative treatment methods must be considered to give new hope for existing sufferers.

Author: Ezree Ebrahim, Business Development Consultant (Healthcare), Akesis Life by Absolute Health. For Further information, please contact: ezree.ebrahim@akesisoncology.com

Series Editor: Christopher F. Bruton, Executive Director, Dataconsult Ltd, chris@dataconsult.co.th. Dataconsults Thailand Regional Forum provides seminars and extensive documentation to update business on future trends in Thailand and in the Mekong Region.

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Healing Garden in Harvard has outgrown its name and helped thousands of cancer survivors – Worcester Business Journal

Posted: December 11, 2019 at 2:41 am

After Virginia Thurston died of breast cancer in 1999, her widower remembered how much the gardens around their home in Harvard gave her comfort during her illness.

Bill Thurston wanted to give solace to others with similar cancer battles, so he donated a portion of their property and a cottage to create the Virginia Thurston Healing Garden to serve women with breast cancer.

Nearly two decades later, the Healing Garden has evolved into a place where anyone fighting cancer can participate in a meditation, yoga, knitting or writing class, or take part in group mindfulness session or another on living a life of meaning.

The acres of gardens from which the center gets its name are still there. Otherwise, the quiet location anyone not closely looking for the driveway is bound to miss it has gained an important role in the area as one of few places where cancer patients can turn to get better in a way not involving medical treatment.

Without them, I probably wouldnt be here right now, said Alice Daugherty of Royalston, who turned to the Healing Garden during a battle with breast cancer.

Daughtery, who has recovered and gave birth early this year to a son, Owen, found the center to be just what she needed to balance the western medicine she was receiving at the Dana-Farber Center Institute in Boston and the eastern medicine her Taiwanese family insisted upon.

Were really focused on nature and being sensory-driven, said Meg Koch, the gardens executive director.

Bill Thurston came up with the plan for the garden with Betsy Tyson-Smith, a psychotherapist and the facilitator of his late wifes hospital support group. He wanted to both honor his wife and support other cancer patients, and Tyson-Smith developed the idea into a center to offer complementary therapies, psycho-social support and the healing environment of nature.

The center, while evolving over the last two decades, has stayed true to its founders vision.

Located down a wooded driveway on Bolton Road south of the town center, the garden is purposefully the opposite type of environment from what can be a cold and sterile conditions in a hospital or medical office. Even after two acres were donated for the Healing Garden along with seed money to get the organization off and running the gardens still required 10 years of work and more funding to get established, with benches and rock outcroppings in some areas, along with a pollinators garden and sculptures that dot the property.

They can reflect in the peace they find with nature, Koch said.

Medical facilities, she added, can be a trigger for cancer patients, even the act of walking into a medical building sometimes stirring panic. The garden acts as a refuge.

It gives them instantaneous distance from being just about cancer, Koch said.

Patients, Koch said, typically first arrive at the center for support groups before turning to the peaceful effects of the gardens. They find the services exactly what they need after going through the toll of cancer treatment, said Brianne Carter, the gardens co-director of integrative care.

Oncology is pretty relentless, Carter said.

The garden has quietly gained a reputation among hospitals in the area, getting referrals from hospitals and centers including Dana-Farber, UMass Memorial Medical Center in Worcester, Lowell General Hospital, Emerson Hospital in Concord.

In fiscal 2019, the garden tallied nearly 3,600 patient visits from more than 300 clients and caregivers. More than 300 therapeutic and educational programs and classes were held.

The gardens more than 1,500 clients in the past nearly two decades have come from 165 cities and towns across the state, with most coming from Acton, Concord and Harvard. Around 30 affiliated practitioners come to the center to give yoga, acupuncture, and other classes.

As its clientele base has grown, the garden has expanded with a new support center it opened in 2008 after a $1-million fundraising campaign. In 2012, it began serving both men and women, and patients no matter their cancer diagnosis. It has also begun collaborations with other nonprofits, including the Worcester Family Health Center, and launched educational programs including one with Lesley University so graduate students of the Cambridge school can complete internships there.

Photo | Grant Welker

The Healing Garden has two acres of landscaped gardens.

The services are free for about a quarter of patients who qualify financially, and transportation to and from the garden is offered for free to clients who need it.

The gardens staff has seen views of less traditional methods of care evolve. What was once called complementary or alternative medicine is now called integrative medicine, and its typically viewed as more central to caring for patients.

Totally, the paradigm has shifted, Koch said.

Among those benefiting from the less-traditional means of care was Daugherty, the breast cancer survivor who was diagnosed just after moving to Royalston with her husband, Scott. They were planning to start a family.

Suddenly, we had to put everything aside, she said.

Daugherty, who teaches music in Worcester, said her Taiwanese family had bad experiences with western medicine and was pushing her to use treatment considering bettering a patients whole body. Daugherty had a double mastectomy, and said she felt ready to quit chemotherapy before arriving at the garden.

At the healing garden, an acupuncture class helped with the side effects of chemotherapy, while the staff and other patients supported her through the fight.

They would inspire me all the time, she said. When I was sick, I felt like no one could understand how I felt.

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More Women are Self-Treating Endometriosis with Cannabis and CBD But is it Safe? – Florence Health

Posted: December 11, 2019 at 2:41 am

For the estimated 11 percent of American women between1 5 and 44 living with endometriosis, symptoms like severe pain, fatigue, and nausea can profoundly disrupt their lives. Yet endometriosis remains under-diagnosed, with a lack of effective treatments.

Thats why many women are taking symptom relief into their own hands by using cannabis, according to a recent survey published this November in the Journal of Obstetrics and Gynaecology Canada. Other women are turning to cannabidiol (CBD) for pain relief, hoping to address the symptoms without the high.

RELATED: This New, CBD-Based Compound Can Reverse CIPNAnd Scientists Discovered It by Accident

Pain relief in endometriosis is an important topic, as it can impact women on so many levels, including work, relationships, academic studies, and of course their mental health, says study co-author Mike Armour, PhD, a post-doctoral research fellow in womens health at Western Sydney Universitys NICM Health Research Institute, a government-funded group that focuses on integrative and complementary medicine research and policy in Australia.

Dr. Armours team surveyed nearly 500 Australian women between the ages of 17 and 45 and found that 13 percent say they use cannabis to self-treat endometriosis symptoms. The authors estimate that their findings suggest approximately 10 percent of Australian women with endometriosis use cannabis for symptom and pain management.

Women frequently report that they cant get endometriosis symptoms under control with recommended medications or surgery; theres little evidence to show current treatments relieve endometriosis pain. NSAIDS like ibuprofen, for one, dont appear to be effective, and theres a strong potential for addiction and abuse with opioid painkillers. Although research suggests hormonal birth control can reduce symptoms, many women stop or avoid using it due to perceived side effects like mood swings and depression.

Women with endometriosis often report that despite various medications, they have pain that is difficult to deal with, Dr. Armour tells Florence Health. Thats why its not surprising theyre turning to cannabis and CBD, he adds, since limited studies suggest these drugs may (or may not) relieve pain.

Cannabis is the most popular illicit drug in the United States; there has been a steady rise in use every year since 2007, with 7.7 percent of American adults reporting using it within the past month as of 2017. That may be in part because its well on its way to becoming a legal medical therapy. A total of 33 states and the District of Columbia have legalized medical marijuana to date; 11 states and D.C. also permit marijuana for recreational use, with another 16 states having decriminalized the possession of small amounts of the drug.

Marijuana remains illegal at the federal level, so the act of prescribing it is still illegal, even in states that have legalized it. Physicians and some APPs can, however, write a recommendation for and discuss the benefits of the plant if the patient suffers from a qualifying condition covered by their local law (usually severe conditions like cancer, HIV/AIDS, glaucoma, or multiple sclerosis).

RELATED: What Clinicians Need to Know About Every FDA-Approved CBD Product

Because the Drug Enforcement Agency classifies cannabis as a schedule 1 drug with more restrictions than even fentanyl or methadone officially, there are no currently accepted medical use and high potential for addiction. It requires a rigorous approval process to study, so to-date theres little peer-reviewed research. That leaves providers hesitant to recommend a drug thats hasnt been rigorously studied and whose contents and dosage arent regulated by the FDA.

Meanwhile, interest in cannabidiol, or CBD, has skyrocketed in recent years. While CBD is an essential component of marijuana, it doesnt contain tetrahydrocannabinol (THC) and therefore doesnt cause a high. A full 14 percent of American adults say they use CBD, according to an August 2019 Gallup poll, most often for pain (40 percent), anxiety (20 percent), and insomnia (11 percent).

Only one CBD-derived drug, which treats seizures in children, has been approved by the Food & Drug Administration (FDA). All 50 states have legalized CBD in some form, and retailers have added it to pretty much any product you can imagine from cheeseburgers to toothpicks to mouth wash.

Cannabis mimics endocannabinoids, natural molecules that act on the endocannabinoid system (ECS), which maintains homeostasis in the body. ECS receptors, in turn, are found throughout the human body. The ECS participates in a wide variety of processes, including pain, stress, sleep, metabolism, immune function and reproduction.

While research is lacking, Dr. Armour says theres another reason to believe cannabis could have a particularly powerful effect on endometriosis pain. Both the uterus and ovaries have highly expressed cannabinoid receptors, he explains. Some researchers even think cannabis could slow the growth of endometrial tissue.

The endocannabinoid system has been found recently to interact with specific mechanisms associated with pain, explains Dr. Armour. It also appears to play an important role in cellular proliferation and apoptosis, which may explain why cannabis is being used by women with endometriosis. However, little has been done clinically to investigate this currently.

While theres little research into cannabis for pain, one recently published paper found it may can effectively reduce pelvic pain and opioid use. In Dr. Armours study, on average, respondents rated the effectiveness of cannabis a 7.6 out of 10, with 55 percent reporting they were able to reduce the need for pharmaceuticals by at least half. Women reported the greatest improvements in sleep and nausea/vomiting, with only 10 percent saying they experienced adverse side effects, like anxiety, drowsiness, and rapid heart rate.

RELATED: Americans Search for Info About CBD Online More Than Any Other Health Product

CBD, meanwhile, appears to have analgesic, anti-inflammatory, and immunomodulatory properties but the jury is out at the moment as to whether it can provide as much potential pain relief in endometriosis as THC does, says Dr. Armour.

For now, researchers agree that theres not enough research to make a conclusion about the benefits or risks of cannabis. People who are at risk of developing addiction or schizophrenia should avoid it altogether, while patients with lung disease should avoid smoking it since it causes airway inflammation, wheezing and chest tightness.

For patients interested in using cannabis, talking with a physician who understands the ECS and has experience in prescribing cannabis is an important first step, says Dr. Armour. Like all medications, it still comes with certain risks.

CBD, on the other hand, may seem less risky to recommend, as it doesnt have the psychoactive effect of THC and no known risk of abuse or dependence, notes Dr. Armour. But there still are dangers.

RELATED: 7 Cant-Miss Talking Points When Patients Ask You about Trying Cannabis

Because CBD isnt regulated by the FDA, its impossible to confirm the exact ingredients or concentration in any given supplement. The FDA has found some CBD products contain contaminants like pesticides and heavy metals.

Whats more, CBD can raise levels of certain medications. [Its] been shown in preclinical and case studies to change the way certain medications are metabolized. It appears to be of more concern than THC in this particular regard, notes Dr. Armour. Providers should ask patients taking CBD about any other medications theyre on and closely monitor for adverse side effects, he adds.

Dr. Armour also calls out the other, nonpharmacological treatments that can address endometriosis symptoms. Some women find relief from heat packs, hot baths, and hot water bottles. Research suggests that acupuncture twice a week for several months may reduce pelvic pain, although its unclear whether the effect lasts after patients complete treatment. And a low-FODMAP diet may help improve any IBS-like symptoms. Just remind patients that this eating plan is for short periods of time.

References:

Endometriosis, WomensHealth.gov.

Cannabis Use, a Self-Management Strategy Among Australian Women With Endometriosis: Results From a National Online Survey, Journal of Obstetrics and Gynaecology Canada.

The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research, National Center for Biotechnology Information.

Patient Outcomes Following Initiation of Medical Cannabis in Women with Chronic Pelvic Pain, the Journal of Minimally Invasive Gynecology.

FDA warns 15 companies for illegally selling various products containing cannabidiol as agency details safety concerns, U.S. Food & Drug Administration.

Cannabidiol (CBD) what we know and what we dont, Harvard Medical School.

Effects of acupuncture for the treatment of endometriosis-related pain: A systematic review and meta-analysis, PLoS ONE.

What Is the Low FODMAP Diet?, Academy of Nutrition and Dietetics.

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Thomas Jefferson University Receives Second Largest Gift in Institution’s History, Paving the Way for New Biomedical Research Building – The Times…

Posted: December 11, 2019 at 2:41 am

PHILADELPHIA, Dec. 9, 2019 /PRNewswire/ --Thomas Jefferson University has received a $70 million gift from Sidney and Caroline Kimmel, which will significantly advance research at Jefferson. The Caroline Kimmel Biomedical Research Building will be a home for big ideas, providing Jefferson scientists with leading-edge technology and laboratories.

"This gift will have a profound and lasting impact on Jefferson's ability to further pursue scientific discovery," said Mark Tykocinski MD, Provost and Executive Vice President for Academic Affairs and the Anthony F. and Gertrude M. DePalma Dean, Sidney Kimmel Medical College at Thomas Jefferson University. "The Caroline Kimmel Biomedical Research Building will serve as a magnet for scientific talent and will bolster our status as an R2 National Research University."

Research is a cornerstone of the University and Jefferson's Reimagine $1 billion campaign. Focused on four key themes, the campaign aims to support talented faculty and students, create spaces that heal and inspire, unite communities for health equity, and fuel discoveries that will improve lives. This landmark gift will round out Jefferson's distinctive integrative approach to research that includes programmatic basic science, clinical and applied.

The new facility will markedly expand Jefferson's research capacity and, along with the Bluemle Life Sciences Building and Jefferson Alumni Hall, will create a "research corridor" along Locust Street. Being physically connected with Bluemle will foster connections with researchers in the Sidney Kimmel Cancer Center, where Mrs. Kimmel serves as a member of the Advisory Council, and the larger Jefferson research community.

Mr. and Mrs. Kimmel are noted philanthropists, supporting medicine and the arts for many years in his native Philadelphia. Mr. Kimmel's first job in the garment industry was as an inventory clerk and later a traveling salesman for a women's wear manufacturer. From there, he joined the iconic clothing company The Villager, rising through the ranks to become its president and CEO. In 1970, Mr. Kimmel established his own clothing line, Jones New York, and during the 70s and 80s became one of the major players in the women's apparel industry. Jones went public in 1991, adding many notable brands to its line including Anne Klein, Nine West, Gloria Vanderbilt, and Stuart Weitzman. Mr. Kimmel served as CEO until 2003 and as chairman until 2014, when The Jones Group was sold for $2.2 billion.

This year, 2019, also marks Mr. and Mrs. Kimmel's 20th wedding anniversary. They were married in 1999 and reside in Southern California just miles from where Mrs. Kimmel was raised. Together, they have continued the many philanthropic endeavors to which Mr. Kimmel committed after taking Jones public.

"I could not be more pleased about this gift; in fact, I am ecstatic," said Sidney Kimmel. "In one act, I have been able to honor my wonderful marriage to Caroline, my home town of Philadelphia, Thomas Jefferson University which I call the Soul of the City, and cancer research to which I have devoted so much of my time and resources. What more could I ask for? I am so fortunate, frankly blessed, to have this opportunity."

"Sidney has proven once again that he's an incredible humanitarian and philanthropist," said Caroline Kimmel. "But where he really shines, is as a husband! I'm profoundly grateful to have my name and our 20th anniversary celebrated in such a meaningful way at Jefferson. This moment forever links our personal commitment to cancer research, our legacy and our abiding love. I couldn't be happier!"

Mr. and Mrs. Kimmel have been extremely generous benefactors to Jefferson, having given more than $200 million over the years including: providing cornerstone funding to establish the Sidney Kimmel Cancer Center in 1995, as well as transformational support for research into the prevention of cardiovascular disease, and Jefferson's largest-ever gift of $110 million to name the Sidney Kimmel Medical College at Thomas Jefferson University in 2014.

"Caroline and Sidney Kimmel have always been able to see the future and to make it more optimistic for everyone," said Stephen K. Klasko, MD, MBA, President of Thomas Jefferson University and CEO of Jefferson Health. "This gift is more than transformative for Jefferson and for cancer research in Philadelphia and beyond. It further embeds Caroline and Sidney's hearts in Philadelphia and as Sidney said, 'Jefferson is the soul of Philadelphia.' It is especially gratifying to me that this will be called the Caroline Kimmel Biomedical Research Building as Mrs. Kimmel has served as an invaluable leader on the Sidney Kimmel Cancer Center Advisory Council."

About Thomas Jefferson University Thomas Jefferson University is a leader in interdisciplinary, professional education. Jefferson, home of the Sidney Kimmel Medical College and the Kanbar College of Design, Engineering and Commerce, is a preeminent university delivering high-impact education in 160 undergraduate and graduate programs to 8,400students in architecture, business, design, engineering, fashion and textiles,health, science and social science. The new Jefferson is re-defining the higher education value proposition with an approach that is collaborative and active; increasingly global; integrated with industry; focused on research across disciplines to foster innovation and discovery; and technology-enhanced. Student-athletes compete as the Jefferson Rams in the NCAA Division II Central Atlantic Collegiate Conference.

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‘Couch potato’ mice reveal that epigenetics affects urge to exercise – BioNews

Posted: December 9, 2019 at 9:46 pm

9 December 2019

For the first time US researchers have shown that not only genetics but a different level of developmental regulation called epigenetics impacts the innate drive of mice to exercise.

Epigenetics is a molecular mechanism within cells that controls which genes are transcribed and which ones are not, determiningwhich genes are 'turned on'and which ones are 'turned off'.

In this study the scientists found that the methylation of DNA, a process which is known to 'turngenes off', in some neurons in the hypothalamus leads to a decrease in exercise activity.

Corresponding author, Dr Robert Waterland, professor at the USDA/ARS Children's Nutrition Research Centre at Baylor and Texas Children's Hospital said: 'We study developmental programming, which refers to how the environment during development can have a long term impact on risk of diseaseour earlier findings suggested that establishment of one's physical activity 'set point'can be affected by early environment, and that this may involve epigenetics.'

Epigenetics is more malleable than genetics and could potentially be altered to increase exercise activity. The scientists investigated a specialised class of neurons in the hypothalamus called AgRP neurons which regulate food intake.

They disabled a gene causing DNA methylation in the AgRP neurons of mice and then tested whether these changes in methylation altered the weight of the animals. Interestingly, they discovered that mice with the disabled gene were slightly heavier.

Intriguingly, the animals did not eat more food than the ones with unchanged DNA methylation. However, the researchers did find a major difference in spontaneous physical exercise. Measuring the distance that the mice ran on a running wheel showed that normal mice ran on average 6 kilometres per night, while the methylation-deficient ones only ran half as much, and thus lost less weight. Notably, the epigenetic changes seemednot to impact the physical ability of the animals to run, but the desire to exercise.

'Our findings suggest that epigenetic mechanisms, such as DNA methylation, that are established in the brain during fetal or early postnatal life, play a major role in determining individual propensity for exercise,'Waterland said. 'Nowadays, as decreases in physical activity contribute to the worldwide obesity epidemic, it is increasingly important to understand how all of this works.'

The work was published in Nature Communications.

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STORM Therapeutics’ Collaborator Awarded ASH-BSH Abstract Achievement Award at the 61st ASH Annual Meeting & Exposition – PR Newswire UK

Posted: December 9, 2019 at 9:46 pm

Konstantinos Tzelepis, PhD, presented award-winning abstract on METTL3

CAMBRIDGE, England, Dec. 9, 2019 /PRNewswire/ -- STORM Therapeutics, the biotechnology company focused on the discovery of small molecule therapies modulating RNA epigenetics announces today, that its collaborator Dr. Konstantinos Tzelepis, Sir Henry Wellcome Fellow and visiting scientist at the Wellcome Sanger Institute, received the ASH-BSH Abstract Achievement Award for his work on STORM Therapeutics' lead programme, METTL3, at the 61st Annual Meeting of the American Society of Hematology (ASH) held on 7th-10th December 2019 in Orlando, Florida.

Dr. Tzelepis received the meritorious award for his abstract entitled 'Pharmacological Inhibition of the RNA m6a Writer METTL3 As a Novel Therapeutics Strategy for Acute Myeloid Leukemia'at the Abstract Achievement Award Ceremony which was held on Saturday, 7th December 2019 at 3:30pm (EST) at the Orange County Convention Center in Exhibit Hall B2-B4.

Dr. Tzelepis's work, which was carried out in collaboration with the Wellcome Sanger Institute and the University of Cambridge, was presented in an oral presentation during the "802. Chemical Biology and Experimental Therapeutics: Novel Compounds and Mechanisms of Action" session on Sunday, 8th December 2019 at 9:30am-11:30am (EST) at the Orange County Convention Centre. The abstract and talk encapsulated the ground-breaking work made on targeting RNA modifying enzymes for cancer treatment and described the recent progress made with the METTL3 inhibitor.

STORM has identified small molecule inhibitors of METTL3 that are orally bioavailable and show pronounced anti-tumour efficacy in physiologically relevant, proof of concept animal models of Acute Myeloid Leukaemia (AML). The talk demonstrated that small molecule inhibition of METTL3 produces the same phenotype and effects previously described in one of STORM's founder scientists' publications using genetic models and validates METTL3 as a druggable target for cancer.

Keith Blundy, CEO of STORM Therapeutics, said:"STORM is progressing fast in its preclinical work with our multiple programmes to showcase the capabilities of our novel platform. STORM is a pioneer in RNA epigenetics and we are very pleased to hear that our collaborator is being recognized for the partnership research of METTL3. As the first company in the world to demonstrate in vivo activity of an RNA methyltransferase inhibitor, we are excited to be leading the field as we look to develop these highly innovative new treatment options for cancer patients."

About STORM

STORM Therapeutics, founded in 2015, is a University of Cambridge spin-out translating the ground-breaking work of Professors Tony Kouzarides and Eric Miska in RNA epigenetics into the discovery of first-in-class drugs in oncology and other diseases. Storm is the leading company tackling disease through modulating RNA modifying enzymes and is developing a unique platform and pipeline to address these enzyme classes, including RNA methyltransferases.

STORM is backed by blue chip investors Cambridge Innovation Capital, M Ventures, Pfizer Ventures, Taiho Ventures LLC, Seroba Life Sciences and IP Group, who share the team's ambitions to build a world-leading company in the field.

The Wellcome Sanger Institute

The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. We are open and collaborative; our data, results, tools and technologies are shared across the globe to advance science. Our ambition is vast we take on projects that are not possible anywhere else. We use the power of genome sequencing to understand and harness the information in DNA. Funded by Wellcome, we have the freedom and support to push the boundaries of genomics. Our findings are used to improve health and to understand life on Earth. Find out more at http://www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn and on our Blog.

SOURCE STORM Therapeutics

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STORM Therapeutics' Collaborator Awarded ASH-BSH Abstract Achievement Award at the 61st ASH Annual Meeting & Exposition - PR Newswire UK

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Global Epigenetics Market Growth 2019-2025 Abcam, Novartis, Roche, Active Motif, Inc., Agilent Technologies, Inc. – Exclusive Industry Reports

Posted: December 9, 2019 at 9:46 pm

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Global Epigenetics Market Growth 2019-2025 Abcam, Novartis, Roche, Active Motif, Inc., Agilent Technologies, Inc. - Exclusive Industry Reports

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Researchers discover why youre skipping the gym for Netflix and sleep – The CEO Magazine

Posted: December 9, 2019 at 9:46 pm

You may have your new years resolutions sorted but following through with your most ambitious fitness goals could be down to genetics.

By Mike Huyhn

Posted on December 6, 2019

Talk about a rude awakening. As another new year rounds the bend there are no doubt plenty of people plotting their annual fitness goals which they will never actually fulfil. You hopeful tragics get an A for effort.

Have you ever wondered though why its easier for the dedicated gym junkies to lift, run, bike and swim on a regular basis whilst others find it hard to get off the couch at all?

Researchers from the Baylor College of Medicine did and thats why they conducted a study to find out why this distinction in motivational behaviour between the dedicated and the lazy existed. The results from the study found that its not really your fault if you cant be bothered gyming its all in your genes.

The research entitled DNA methylation in AgRP neurons regulates voluntary exercise behaviour was published in Nature Communications. It highlights the epigenetic control of the expression of certain genes. These particular epigenetic mechanisms are explained to be more malleable than pure genetics alone, suggesting that there is still a way to program people into being more physically driven rather than just blaming genetics.

How they reached this conclusion was through the creation of an epigenetic couch potato mouse. In this test subject, the researchers analysed changes in the DNA methylation in neurons within the hypothalamus. Basically science jargon which says they found a link between the couch potato mouse and voluntary exercise behaviour.

Our earlier findings suggested that establishment of ones physical activity set point can be affected by early environment, and that this may involve epigenetics, explained corresponding author Robert A. Waterland, PhD, professor of pediatrics nutrition at the USDA/ARS Childrens Nutrition Research Center at Baylor and Texas Childrens Hospital.

Further investigations were conducted to test whether DNA methylation in the brain affects energy balance. Researchers implemented running cages in the animals cages for eight weeks and observed the difference between two specific groups. The normal male mice ran approximately 6km every night whilst the mice with a specific gene blocked only ran half the distance. Naturally the latter group also lost less fat.

What the researchers concluded from the experiment was that the gene-deficient mice were capable of running the same distance as normal mice but simply lacked the desire to.

Our findings suggest that epigenetic mechanisms, such as DNA methylation, that are established in the brain during fetal or early postnatal life, play a major role in determining individual propensity for exercise, Waterland said.

Nowadays, as decreases in physical activity contribute to the worldwide obesity epidemic, it is increasingly important to understand how all of this works.

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Researchers discover why youre skipping the gym for Netflix and sleep - The CEO Magazine

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