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Stem Cell And Regenerative Therapy Market lucrative opportunities by 2024 – Crypto News Byte

Posted: December 9, 2019 at 9:44 pm

The global stem cell and regenerative medicines market should grow from $21.8 billion in 2019 to reach $55.0 billion by 2024 at a compound annual growth rate (CAGR) of 20.4% for the period of 2019-2024.

Report Scope:

The scope of this report is broad and covers various type of product available in the stem cell and regenerative medicines market and potential application sectors across various industries. The current report offers a detailed analysis of the stem cell and regenerative medicines market.

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The report highlights the current and future market potential of stem cell and regenerative medicines and provides a detailed analysis of the competitive environment, recent development, merger and acquisition, drivers, restraints, and technology background in the market. The report also covers market projections through 2024.

The report details market shares of stem cell and regenerative medicines based on products, application, and geography. Based on product the market is segmented into therapeutic products, cell banking, tools and reagents. The therapeutics products segments include cell therapy, tissue engineering and gene therapy. By application, the market is segmented into oncology, cardiovascular disorders, dermatology, orthopedic applications, central nervous system disorders, diabetes, others

The market is segmented by geography into the following regions: North America, Europe, Asia-Pacific, South America, and the Middle East and Africa. The report presents detailed analyses of major countries such as the U.S., Canada, Mexico, Germany, the U.K. France, Japan, China and India. For market estimates, data is provided for 2018 as the base year, with forecasts for 2019 through 2024. Estimated values are based on product manufacturers total revenues. Projected and forecasted revenue values are in constant U.S. dollars, unadjusted for inflation.

Report Includes:

28 data tables An overview of global markets for stem cell and regenerative medicines Analyses of global market trends, with data from 2018, estimates for 2019, and projections of compound annual growth rates (CAGRs) through 2024 Details of historic background and description of embryonic and adult stem cells Information on stem cell banking and stem cell research A look at the growing research & development activities in regenerative medicine Coverage of ethical issues in stem cell research & regulatory constraints on biopharmaceuticals Comprehensive company profiles of key players in the market, including Aldagen Inc., Caladrius Biosciences Inc., Daiichi Sankyo Co. Ltd., Gamida Cell Ltd. and Novartis AG

Summary

The global market for stem cell and regenerative medicines was valued at REDACTED billion in 2018. The market is expected to grow at a compound annual growth rate (CAGR) of REDACTED to reach approximately REDACTED billion by 2024. Growth of the global market is attributed to the factors such as growingprevalence of cancer, technological advancement in product, growing adoption of novel therapeuticssuch as cell therapy, gene therapy in treatment of chronic diseases and increasing investment fromprivate players in cell-based therapies.

In the global market, North America held the highest market share in 2018. The Asia-Pacific region is anticipated to grow at the highest CAGR during the forecast period. The growing government funding for regenerative medicines in research institutes along with the growing number of clinical trials based on cell-based therapy and investment in R&D activities is expected to supplement the growth of the stem cell and regenerative market in Asia-Pacific region during the forecast period.

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Reasons for Doing This Study

Global stem cell and regenerative medicines market comprises of various products for novel therapeutics that are adopted across various applications. New advancement and product launches have influenced the stem cell and regenerative medicines market and it is expected to grow in the near future. The biopharmaceutical companies are investing significantly in cell-based therapeutics. The government organizations are funding research and development activities related to stem cell research. These factors are impacting the stem cell and regenerative medicines market positively and augmenting the demand of stem cell and regenerative therapy among different application segments. The market is impacted through adoption of stem cell therapy. The key players in the market are investing in development of innovative products. The stem cell therapy market is likely to grow during the forecast period owing to growing investment from private companies, increasing in regulatory approval of stem cell-based therapeutics for treatment of chronic diseases and growth in commercial applications of regenerative medicine.

Products based on stem cells do not yet form an established market, but unlike some other potential applications of bioscience, stem cell technology has already produced many significant products in important therapeutic areas. The potential scope of the stem cell market is now becoming clear, and it is appropriate to review the technology, see its current practical applications, evaluate the participating companies and look to its future.

The report provides the reader with a background on stem cell and regenerative therapy, analyzes the current factors influencing the market, provides decision-makers the tools that inform decisions about expansion and penetration in this market.

Report Description: https://www.trendsmarketresearch.com/report/analysis/BCC/global-stem-cell-and-regenerative-therapy-market

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The World Is Getting Better. Its Just That No One Tells You About It. – National Review

Posted: December 9, 2019 at 9:44 pm

(Thomas Peter/Reuters)

A special Morning Jolt today, as I try to run through a long but by no means complete list of good news from the past year that was astoundingly under-reported and discussed, particularly when compared to presidential tweets, discussions of which pop culture offerings werent woke enough, glowing profiles of the eighth or ninth-most popular Democratic presidential candidate, and so on . . .

Weve Made Some Breathtaking Advances

You will be stunned when you realize how many dramatic breakthroughs have been made against some of the most common and deadly diseases and ailments out there.

One: A new blood test could detect breast cancer five years before other clinical signs manifest. This could be available to patients in four to five years. Separately, a new treatment for early-stage breast cancer could wipe out a growth in just one treatment.

Two: Anewthree-drug combination therapy could provide significant help to up to 90 percent of those suffering from cystic fibrosis.

Three: We could soon see a pill that can prevent heart attacks in high-risk patients: Drugmaker Amarin shocked the world last year when along-running clinical trial showed that itsmedicine derivedfrompurified fish oil, Vascepa, substantially reduced the risk of cardiovascular events like heart attacks in high-risk patients . . . In November,a panel of experts convened by the Food and Drug Administration reviewed Amarinsdata. They voted16 to 0that Vascepa was safe and cuts cardiovascular events.

Four: Israeli researchers think theyve discovered that a molecule designed to help stroke victims may be a new way to wipe out pancreatic cancer, which is one of the toughest cancers to treat.

Five: The Mayo Clinic injected stem cells derived from fat cells into a paralyzed patients spine and the patient is now walking again. This treatment may not work as well for every patient, but it provides new hope for everyone facing paralysis.

You can get stem cells from fat cells? Good heavens, I think Ive found my calling.

Six: A new vaccine could eliminate allergies to cats.

Seven: Earlier this year, UC San Francisco researchers managed to transform human stem cells into mature insulin-producing cells, a major breakthrough in the effort to develop a cure for type 1 diabetes.

Eight: In July, researchers successfully eliminated HIV from the DNA ofinfected mice for the first time,bringing themone step closer to curing the virus in humans.

Nine: Two new treatments for the deadly Ebola virus saved roughly 90 percent of the patients who were newly infected.

Ten: Gene therapy developed atSt. JudeChildrens Research Hospital has cured infants born with X-linked severe combined immunodeficiency, more commonly known as bubble boy disease. The children are producing functional immune cells, including T cells, B cells and natural killer (NK) cells, for the first time.

Keep headlines like the ones above in mind the next time you hear some politician denouncing those greedy pharmaceutical companies.

Turning our attention to the American economy, youve heard about the low unemployment rate. What you may not have heard is that the workforce participation rate for those between 25 and 54 years old is up to 80.1 percent the highest since early 2007.

If thats eleven, then twelve would be the U.S. Census Bureaus latest report on income and poverty, which came out in October. That report found real median family income up 1.2 percent from 2017 to 2018, real median earnings up 3.4 percent, the number of full-time, year-round workers increased by 2.3 million, and the poverty rate declined from 12.3 percent to 11.8 percent, with 1.4 million people leaving poverty.

Thirteen: Despite predictions that Amazon was going to put bookstores out of business, the number of independent bookstores keeps rising each year the most recent figures are 1,887 independent bookselling companies running 2,524 stores.

Fourteen: The cost of lithium-ion batteries is down about 87 percent over the past decade which makes electric vehicles a more cost-effective option for transporting goods and people.

Fifteen: Theres a lot of ugly trade wars and tariffs going on, but there is progress on some fronts. Japan just approved a deal that will lower or remove tariffs on $7.2 billion in U.S. farm goods, including a gradual reduction of its 38.5 percent duty on American beef to 9 percent. Other U.S. products including pork, wine and cheese will also get greater market access, putting the United States on a level playing field with TPP members such as Australia and Canada. The European Parliament voted last month to approve a plan that grants the U.S. a country-specific share of the European Unions duty-free, high-quality beef quota.

Sixteen: In September, for the first time in 70 years, the United States exported more crudeoil and petroleum products than it imported per day. Back in 2006, we were importing 13 million barrels a day. Around that time, America set out to reduce its dependence on foreign oil. Thanks to fracking and innovation, we did it.

Turning our attention to the environment, bald eagles, once on the endangered species list, are now so plentiful that San Bernardino National Forest officials are ending their annual count.

Thats seventeen. Number eighteen would arrive from over in the United Kingdom, a new study of endangered carnivorous mammals finds two of the three rarer carnivores (pine marten and polecat) have staged remarkable recoveries, while the third (wildcat) continues to be threatened by hybridisation. Meanwhile, akin to pine martens and polecats, the formerly rare and restricted otter has recovered much of its former range and is increasing in density.

Nineteen: The world is literally a greener place than it was 20 years ago, and data from NASA satellites has revealed a counterintuitive source for much of this new foliage: China and India. A new study shows that the two emerging countries with the worlds biggest populations are leading the increase in greening on land. The effect stems mainly from ambitious tree planting programs in China and intensive agriculture in both countries.

Twenty: NASA also found that abnormal weather patterns in the upper atmosphere over Antarctica dramatically limited ozone depletion in September and October, resulting in the smallest ozone hole observed since 1982.

Twenty-one: A study unveiled in November estimates that humpbacks in the western South Atlantic region now number 24,900 nearly 93 percent of their population size before they were hunted to the brink of extinction. Good news, crew of the Enterprise, you may not need to use a stolen Klingon ship to find two humpbacks to save the future.

Twenty-two: The National Oceanic and Atmospheric Administration spotted and recorded video of a kraken okay, a giant squid that was at least 10 feet long only about 100 miles southeast of New Orleans, shortly before their vessel was struck by lightning. Okay, technically this could be bad news.

Turning our attention overseas, you heard about the raid against al-Baghdadi and the collapse of the Islamic State. You probably didnt hear that the number of ISIS fighters in Afghanistan is now reduced to around 300 fighters in Afghanistan, from an estimated 3,000 earlier this year.

Thats twenty-three; twenty-four would be the impact of terrorism. We wont know 2019s numbers until the year ends, but deaths from terrorism fell for the fourth consecutive year in 2018, after peaking in 2014. The number of deaths has now decreased by 52 percent since 2014, falling from 33,555 to 15,952, says the 2019Global Terrorism Index.

Twenty-five: The number of malaria infections recorded globally has fallen for the first time in several years. In 2018, Cambodia reported zero malaria-related deaths for the first time in the countrys history. India also reported a huge reduction in infections, with 2.6 million fewer cases in 2018 than in 2017.

Twenty-six: Tensions between India and Pakistan got worse overall this year over Kashmir, but India and Pakistanmanaged to cooperate on breaking ground on a new peace corridor that will allow more than 5,000 Sikh pilgrims to travel back and forth across the normally impassable border visa-free for the first time in 72 years.

Twenty-seven: Israeli scientists have genetically engineered an E. Coli bacteria that eat carbon dioxide.

Twenty-eight through thirty-one come from the realm of remarkable discoveries about our past. Archeologists made amazing discoveries in the past year. A 1,300-year-old rook found in the Jordanian desert may be the worlds oldest chess piece. They discovered a new humanoid Nazca line in Peru. Sometime fourth century B.C. and sixth century A.D., in what is today Iran, some civilization built a big beautiful wall running about 71 miles; it appears Mexico didnt pay for that one, either. And in Jerusalem, archeologists found that a grand street running from the Siloam Pool to the Temple Mount was built by some guy named . . . er, Pontius Pilate.

You hear about this stuff a lot less because articles and television segments about these developments dont make you more likely to respond in the comments section, more likely to share on social media, more likely to call into a talk radio program, or more likely to vote for a particular candidate. It doesnt make you believe that the world is full of people who are being unfair to you, that youre a victim, or that other people are responsible for your problems.

ADDENDUM: Whatever your day holds, it probably doesnt include chaperoning an elementary school field trip with fourth graders that includes long bus rides to and from our educational destination. Heres hoping not too many kids barf today.

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3D Cell Cultures Market Detailed Analysis of Business Opportunities, Growth & Forecast to 2024 – Daily Market Insight

Posted: December 9, 2019 at 9:44 pm

The 3D Cell Cultures market is expected to see a growth of12.8% according to latest report released by AMA Research highlighting development scenario with compelling market sizing by revenue and volume (Consumption, Production)* ranging from 2013-2025. The study feature not only specific market forecasts, but also include significant value-added commentary on Market Trends, Technological Trends and Innovations, Regulatory Trends and Policies, Market Maturity Indicators, Market Share Movements, Growth Drivers and Constraints, New Entrants into the Market & Entry/Exit Barriers and Consumer Demographics.

Some of the profiled players in study out of the total coverage list includes

Merck Sharp & Dohme Corp. (United States), Sigma Corporation (Japan), Lonza Group (Switzerland), 3D Biomatrix (United States), Ams Biotechnology (United Kingdom), Life Technologies Corporation (United States), Microtissues Inc. (United States), Labome.Org (United States), Tecan Group Ltd. (Switzerland), Lena BioSciences (United States), 3D Biotek (United States)

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3D Cell Cultures Market Definition: 3D cell culture is an in vitro technique where cells are grown in an artificially created environment, which resembles the in vivo environment. This technique stimulates the normal cell to differentiate, proliferate, and migrate by interacting with their three-dimensional surroundings. 3D cell culture nurtures levels of cell differentiation and tissue organization which is not viable in traditional 2D culture systems. The Technique has more tissue divergence and cell cohesion properties. Cell studies have evolved from being performed on 2D surfaces to a 3D configuration to mimic more closely their natural 3D habitat in the body which is referred to 3D cell culture. A number of Research Organizations and leading market companies are increasing investment in 3D cell culture, thereby fueling the market for 3D cell culture technique on a Global level.

Market Scope Overview: by Type (Membrane Type, Foam / gel Type, Microcarriers Type), Application (Tissue Engineering, Tumor Model, Stem Cell Research, Drug Discovery, Regenerative Medicine), End users (Biotechnology and pharmaceutical industries, Research laboratories and institutes, Hospitals and diagnostic centers, Others), Technology (Scaffold (Hydrogels, Polymeric scaffolds, Micropatterned Surface Microplates), Scaffold-Free (Hanging drop microplates, Spheroid microplates containing Ultra Low Attachment (ULA) coating), Microfluidic 3D cell culture, Magnetic levitation & 3D bioprinting), 3D Bioreactors), Component (Media, Reagents and Consumables)

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Check Inside Story on Trending Factors with Regional Attention:

Use of Microchips to Implement Culturing through Use of Micro-fabricated Tissue Component

Government Investments for Healthcare Due To Increased Risk of Diseases Such As Cancer

Increasing Adoption of Tissue Engineering and Organ Transplantation for Chronic Diseases

Focus on Developing Alternatives for Animal Testing

Technological Advancement and Product Launch

Lack of Consistency in 3D Cell Culture Technique

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Country Level Break-up of market Size with Cross Segmentation includes:

North America (United States, Canada and Mexico)

Europe (Germany, France, United Kingdom, Spain, Italy, Netherlands, Switzerland, Nordic, Others)

Asia-Pacific (Japan, China, Australia, India, Taiwan, South Korea, Middle East & Africa, Others)

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Table of Content

Global 3D Cell Cultures Market Research Report

Chapter 1 Global 3D Cell Cultures Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Productions, Revenue (Value) by Region

Chapter 5 Global Supplies (Production), Consumption, Export, Import by Regions

Chapter 6 Global Productions, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global 3D Cell Cultures Market Forecast

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2019: The year gene therapy came of age – Jamaica Observer

Posted: December 9, 2019 at 9:42 pm

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WASHINGTON DC, United States (AFP) In the summer, a mother in Nashville with a seemingly incurable genetic disorder finally found an end to her suffering by editing her genome.

Victoria Gray's recovery from sickle cell disease, which had caused her painful seizures, came in a year of breakthroughs in one of the hottest areas of medical research gene therapy.

I have hoped for a cure since I was about 11, the 34-year-old told AFP in an e-mail.

Since I received the new cells, I have been able to enjoy more time with my family without worrying about pain or an out-of-the-blue emergency.

Over several weeks, Gray's blood was drawn so doctors could get to the cause of her illness stem cells from her bone marrow that were making deformed red blood cells.

The stem cells were sent to a Scottish laboratory, where their DNA was modified using Crispr/Cas9 pronounced Crisper a new tool informally known as molecular scissors.

The genetically edited cells were transfused back into Gray's veins and bone marrow. A month later, she was producing normal blood cells.

Medics warn that caution is necessary but, theoretically, she has been cured.

This is one patient. This is early results. We need to see how it works out in other patients, said her doctor, Haydar Frangoul, at the Sarah Cannon Research Institute in Nashville.

But these results are really exciting.

In Germany, a 19-year-old woman was treated with a similar method for a different blood disease, beta thalassemia. She had previously needed 16 blood transfusions per year.

Nine months later, she is completely free of that burden.

For decades, the DNA of living organisms such as corn and salmon has been modified.

But Crispr, invented in 2012, made gene editing more widely accessible. It is much simpler than preceding technology, cheaper and easy to use in small labs.

The technique has given new impetus to the perennial debate over the wisdom of humanity manipulating life itself.

It's all developing very quickly, said French geneticist Emmanuelle Charpentier, one of Crispr's inventors and the co-founder of Crispr Therapeutics, the biotech company conducting the clinical trials involving Gray and the German patient.

Cures

Crispr is the latest breakthrough in a year of great strides in gene therapy, a medical adventure started three decades ago, when the first TV telethons were raising money for children with muscular dystrophy.

Scientists practising the technique insert a normal gene into cells containing a defective gene.

It does the work the original could not such as making normal red blood cells, in Victoria's case, or making tumour-killing super white blood cells for a cancer patient.

Crispr goes even further; instead of adding a gene, the tool edits the genome itself.

After decades of research and clinical trials on a genetic fix to genetic disorders, 2019 saw a historic milestone: approval to bring to market the first gene therapies for a neuromuscular disease in the US and a blood disease in the European Union.

They join several other gene therapies bringing the total to eight approved in recent years to treat certain cancers and an inherited blindness.

Serge Braun, the scientific director of the French Muscular Dystrophy Association, sees 2019 as a turning point that will lead to a medical revolution.

Twenty-five, 30 years, that's the time it had to take, he told AFP from Paris.

It took a generation for gene therapy to become a reality. Now, it's only going to go faster.

Just outside Washington, at the National Institutes of Health (NIH), researchers are also celebrating a breakthrough period.

We have hit an inflection point, said Carrie Wolinetz, NIH's associate director for science policy.

These therapies are exorbitantly expensive, however, costing up to US$2 million meaning patients face gruelling negotiations with their insurance companies.

They also involve a complex regimen of procedures that are only available in wealthy countries.

Gray spent months in hospital getting blood drawn, undergoing chemotherapy, having edited stem cells reintroduced via transfusion and fighting a general infection.

You cannot do this in a community hospital close to home, said her doctor.

However, the number of approved gene therapies will increase to about 40 by 2022, according to MIT researchers.

They will mostly target cancers and diseases that affect muscles, the eyes and the nervous system.

Bioterrorism

Another problem with Crispr is that its relative simplicity has triggered the imaginations of rogue practitioners who don't necessarily share the medical ethics of Western medicine.

Last year in China, scientist He Jiankui triggered an international scandal and his excommunication from the scientific community when he used Crispr to create what he called the first gene-edited humans.

The biophysicist said he had altered the DNA of human embryos that became twin girls Lulu and Nana.

His goal was to create a mutation that would prevent the girls from contracting HIV, even though there was no specific reason to put them through the process.

That technology is not safe, said Kiran Musunuru, a genetics professor at the University of Pennsylvania, explaining that the Crispr scissors often cut next to the targeted gene, causing unexpected mutations.

It's very easy to do if you don't care about the consequences, Musunuru added.

Despite the ethical pitfalls, restraint seems mainly to have prevailed so far.

The community is keeping a close eye on Russia, where biologist Denis Rebrikov has said he wants to use Crispr to help deaf parents have children without the disability.

There is also the temptation to genetically edit entire animal species malaria-causing mosquitoes in Burkina Faso or mice hosting ticks that carry Lyme disease in the US.

The researchers in charge of those projects are advancing carefully, however, fully aware of the unpredictability of chain reactions on the ecosystem.

Charpentier doesn't believe in the more dystopian scenarios predicted for gene therapy, including American biohackers injecting themselves with Crispr technology bought online.

Not everyone is a biologist or scientist, she said.

And the possibility of military hijacking to create soldier-killing viruses or bacteria that would ravage enemies' crops?

Charpentier thinks that technology generally tends to be used for the better.

I'm a bacteriologist we've been talking about bioterrorism for years, she said. Nothing has ever happened.

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Trevena Inc. (TRVN)’s Financial Results Comparing With VistaGen Therapeutics Inc. (NASDAQ:VTGN) – The Broch Herald

Posted: December 9, 2019 at 9:42 pm

Trevena Inc. (NASDAQ:TRVN) and VistaGen Therapeutics Inc. (NASDAQ:VTGN), are influenced by contrast since they are both players in the Biotechnology. These factors are particularly influence the analyst recommendations, profitability, risk, dividends, institutional ownership, earnings and valuation of the two firms.

Earnings and Valuation

We can see in table 1 the earnings per share (EPS), gross revenue and valuation of Trevena Inc. and VistaGen Therapeutics Inc.

Profitability

Table 2 provides us the net margins, return on assets and return on equity of both companies.

Volatility and Risk

Trevena Inc.s current beta is 2.39 and it happens to be 139.00% more volatile than S&P 500. From a competition point of view, VistaGen Therapeutics Inc. has a -0.48 beta which is 148.00% less volatile compared to S&P 500.

Liquidity

The Current Ratio and a Quick Ratio of Trevena Inc. are 3.6 and 3.6. Competitively, VistaGen Therapeutics Inc. has 4.9 and 4.9 for Current and Quick Ratio. VistaGen Therapeutics Inc.s better ability to pay short and long-term obligations than Trevena Inc.

Analyst Recommendations

The table delivered features the ratings and recommendations for Trevena Inc. and VistaGen Therapeutics Inc.

Trevena Inc.s upside potential currently stands at 394.84% and an $3.5 average target price. Competitively VistaGen Therapeutics Inc. has an average target price of $22, with potential upside of 4,957.47%. The results from earlier shows that analysts opinion suggest that VistaGen Therapeutics Inc. seems more appealing than Trevena Inc.

Institutional & Insider Ownership

The shares of both Trevena Inc. and VistaGen Therapeutics Inc. are owned by institutional investors at 32.2% and 20.4% respectively. 1% are Trevena Inc.s share owned by insiders. Competitively, VistaGen Therapeutics Inc. has 0.2% of its share owned by insiders.

Performance

Here are the Weekly, Monthly, Quarterly, Half Yearly, Yearly and YTD Performance of both pretenders.

For the past year Trevena Inc. has 120.93% stronger performance while VistaGen Therapeutics Inc. has -66% weaker performance.

Summary

On 8 of the 11 factors Trevena Inc. beats VistaGen Therapeutics Inc.

Trevena, Inc., a biopharmaceutical company, develops various therapies based on breakthrough science to benefit patients and healthcare providers confronting serious medical conditions. Its product candidates include oliceridine injection, a -receptor G protein pathway selective modulator, which is in Phase III clinical trials for the management of moderate-to-severe acute pain where intravenous administration is preferred; TRV250, a G protein biased ligand targeting the d-receptor, which is in preclinical development for the treatment of migraine; and TRV734, a small molecule G protein biased ligand at the mu-receptor that is in Phase I clinical trials for the treatment of moderate to severe acute and chronic pain, as well as TRV027 for the treatment of acute heart failure. Trevena, Inc. was founded in 2007 and is headquartered in King of Prussia, Pennsylvania.

VistaGen Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in developing and commercializing medicines for depression and other central nervous system (CNS) disorders. The company's lead product candidate is AV-101, which is in Phase II development stage, an adjunctive treatment used for major depressive disorder. It also focuses on potential commercial applications of its human pluripotent stem cell (hPSC) technology platform to discover, rescue, develop, and commercialize new chemical entities (NCEs) for CNS and other diseases; and regenerative medicine involving hPSC-derived blood, cartilage, heart, and liver cells. In addition, the company develops CardioSafe 3D, an in vitro cardiac bioassay system for predicting human heart toxicity of small molecule NCEs. VistaGen Therapeutics, Inc. has licensing, sublicensing, and collaboration agreements with BlueRock Therapeutics, LP; U.S. National Institutes of Health; Cato Research Ltd.; and University Health Network. The company was founded in 1998 and is headquartered in South San Francisco, California.

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Trevena Inc. (TRVN)'s Financial Results Comparing With VistaGen Therapeutics Inc. (NASDAQ:VTGN) - The Broch Herald

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Veritas Genetics, the start-up that can sequence a human genome for less than $600, ceases US operations and is in talks with potential buyers – CNBC

Posted: December 9, 2019 at 9:41 pm

Veritas Genetics had big plans to lower the price of sequencing the human genome, making it on par with the price of buying an Apple Watch or a fancy dinner.

The company, which was the first in the world to map out a person's DNA for less than $1,000 back in 2016, just shared with customers via email that it is ceasing operations in the U.S.

"Due to an unexpected adverse financing situation, we are being forced to suspend our operations in the U.S. for the time being," the email, which was viewed by CNBC, reads. "We are currently assessing all paths forward, including strategic options."

The company also laid off the bulk of its employees based in the U.S., about 50 people, earlier this week, according to a source familiar with the company. The source asked not to be named because they were not authorized to speak for Veritas Genetics.

"I can clarify this temporarily affects U.S. operations only," a spokesperson for the company said. "All of the customers outside of the U.S. will continue to be served by Veritas Europe and Latin America."

Veritas, which made this year's CNBC Disruptor 50 list, hoped to expand to millions more consumers in the coming years by bringing down the price of whole genome sequencing to just a few hundred dollars. It raised more than $50 million in financing since it got its start in 2015.

But the company's investors, including Simcere Pharmaceutical and Lilly Asia Ventures, are based in China, at a time when the Trump administration is cracking down on Chinese firms making investments in U.S. companies. Earlier this year, the Committee on Foreign Investment in the United States,or CFIUS, forced a health-tech company called PatientsLikeMe to find a buyer after ordering its Chinese owner to divest its stake. PatientsLikeMe eventually sold to UnitedHealth.

For Veritas, it meant that new investors who were interested in the business got skittish because of the potential for oversight from CFIUS, according to the person familiar with the company. As a result, Veritas has also been in talks with potential acquirers in recent months, said the person.

If Veritas is able to figure out a path forward, it hopes to be competitive with companies such as Ancestry and 23andMe by offering more information for about the same price. 23andMe has dabbled with offering sequencing to its customers, but currently provides only genotyping services, meaning it looks at specific parts of the genome which are known to be associated with a certain condition or trait.

While 23andMe and Ancestry primarily sell tests for people interested in their ancestral composition and wellness traits, Veritas has long stressed that it's different because it provides potentially actionable insights into its users' health.

Veritas' decision to stop selling its tests in the U.S. comes as other consumer-facing DNA testing companies report that sales have slowed. One potential factor is that people have grown more concerned about protecting their privacy, especially in the wake of high-profile news events such as the Golden State Killer case. That stoked fears about whether individuals could be found and convicted for past crimes based on distant relatives' DNA.

But for Veritas, which bills itself as more of a medical company, sales of its tests have been increasing since it dropped its price in July, according to the person familiar.

Veritas in November experienced a security breach that included some customer information, the start-up confirmed to Bloomberg. The company stressed that only a handful of people were affected.

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Caris Life Sciences, Ambry Genetics Team on New Hereditary Cancer Panel – Clinical OMICs News

Posted: December 9, 2019 at 9:41 pm

Caris Life Sciences has announced it will begin offering Ambry Genetics 67- gene CancerNext Expanded panel to evaluate hereditary risks for cancer. That test will now be available combined with Caris somatic (tumor) tests that analyze a cancers detailed molecular makeup. In a release, Caris says this will be: The most comprehensive, clinically relevant molecular and genetic offering on the market today to guide treatment and management of cancer. The combined Caris and Ambry testing is already available nationwide.

We are committed to providing clinicians with high-quality information they can use to inform treatment decisions, said David D. Halbert, Caris Life Sciences Chairman, CEO and founder. By partnering with Ambry Genetics to better inform patient care, we are able to provide clinicians a greater ability to learn about a cancers molecular composition.

According to the National Cancer Institute, about 10% of cancers are hereditary. Inherited cancers often occur at a relativelyearly age and involve pathogenic variants in one or more genes. The most common hereditary cancer syndromes in women include hereditary breast and ovarian cancer syndrome, Lynch syndrome, LiFraumeni syndrome, Cowden syndrome, PeutzJeghers syndrome, and hereditary diffuse gastric cancer. A hereditary cancer risk assessment identifies patients and families who may be at increased risk of developing certain types of cancer.

Caris currently offers clinicians Caris Molecular Intelligence, a proprietary, comprehensive tumor profiling approach that assesses DNA, RNA, and proteins that are unique to an individuals cancer, among other products. The Molecular Intelligence test reveals a molecular blueprint aimed to guide more precise and individualized treatment decisions.

Through the partnership, Caris will now also offer Ambrys CancerNext-Expandedhereditary cancer panel, which analyzes 67 genes associated with an increased hereditary risk of cancer, including brain, breast, colon, ovarian, pancreatic, prostate, renal, uterine, and many other cancers. This test identifies inherited risks for cancer in order for clinicians to accurately diagnose, treat, and manage cancer risks for each patients needs.

To best diagnose and treat cancer, clinicians must understand whether patients have mutations in genes associated with an increased risk for hereditary cancer, said Aaron Elliott, Chief Executive Officer of Ambry. Caris molecular tests combined with Ambrys germline genetic testing, give clinicians the most comprehensive, clinically relevant molecular profile on the market to guide treatment and management.

Being able to simultaneously conduct comprehensive tumor genomic testing and multi-gene germline sequencing is invaluable, especially for sick patients at the beginning of their cancer journey, said Michael J. Hall, M.D., and chair, Department of Clinical Genetics at Fox Chase Cancer Center. This is information I can immediately begin using for my patients to more accurately diagnose them and to better individualize their treatments.

In further news from Caris, the National Comprehensive Cancer Network (NCCN) updated their treatment guidelines for Non-Small Cell Lung Cancer (NSCLC), which stress the importance ofRNA profilingand noteDNA-based next-generation sequencing may under-detectNTRK1andNTRK3fusions.Caris offers a suite of molecular profiling offerings, including whole transcriptome sequencing with MI Transcriptome which they say provides themost comprehensive and unique RNA analysis available and covers all 22,000 genes.

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Extinction of farm animals threatens food security and genetic diversity – ABC News

Posted: December 9, 2019 at 9:41 pm

Australian agriculture is rapidly breeding out diversity within farmed animals, genetics which could one day be the key to stopping diseases and adapting to changing environments.

The University of Western Australia's Catie Gressier said while extinction and biodiversity were issues often associated with native species, heritage and rare breeds of agricultural animals were also under threat, and many had already been lost.

"It's really quite alarming," she said.

"Globally, since the early '90s, we've been losing a breed a month it's a really massive issue.

"With the industrialisation of agriculture, there's been a really strong focus on profitability and there's been a real shift towards a small number of productive hybrids that now dominate the industry almost totally worldwide."

Wessex Saddleback pigs are 'at risk' of extinction in Australia.

(Supplied: James Bennett)

Wessex Saddleback pigs are 'at risk' of extinction in Australia.

Dr Gressier said most breeds had been lost over the past 30 years with market forces dominating what breeds were farmed for meat.

And she said that could be to the peril of agriculture's long-term sustainability.

"Having a biodiverse environment is so critical in order to have a responsiveness and an adaptability to unforeseen changes occurring climatically [and] economically, in terms of consumer preferences, and also in terms of profitability," she said.

Dr Gressier pointed to the current threat of African Swine Fever on the pig industry as a global disease where a range of genetics within existing breeds could be examined for naturally occurring tolerance or resistance.

British White cattle is known for its high eating quality but it is listed as "at risk" by the Rare Breeds Trust of Australia.

(ABC Central Victoria: Larissa Romensky)

British White cattle is known for its high eating quality but it is listed as "at risk" by the Rare Breeds Trust of Australia.

ABC Central Victoria: Larissa Romensky

"Different genetic pools have different capabilities to demonstrate resistance to various diseases," she said.

"We need to have that agility for these new risks.

"In terms of improving stock, a diversity of genetics is really valuable but [so is] mitigating against some of the risks around disease and climate changes that are occurring."

Poultry breeders say it is becoming very difficult to get new genetics for some types of ducks and chickens.

(Contributed: Pip Rumble)

Poultry breeders say it is becoming very difficult to get new genetics for some types of ducks and chickens.

Dr Gressier said Australia had no cryo-conservation facilities to collect and store sperm and embryos and laws for some species, such as pigs, did not permit the importation of genetic material.

"The whole conservation effort is in the hands of individual farmers, volunteer organisations, and rare breed societies such as the Rare Breeds Trust of Australia," she said.

She urged consumers to buy meat from rare breed animals in order to support continued commercial production.

"For example, pork that's coming from Hampshires or Tamworths or Wessex Saddlebacks [pig breeds] that are in a really endangered states," she said.

"If you can support farmers that are growing these breeds that's a really positive step.

"To preserve these animals in our economic situation, it really is about finding how they can have some sort of economic viability."

In the West Australian wheatbelt, Linton and Kerry Batt have run a commercial herd of Berkshire pigs for the past 10 years.

Berkshires produce fewer pigs per litter and are slower to grow in comparison to the Landrace or Large White breeds which dominate commercial piggeries.

Mr Batt said he marketed his Berkshire pork as being the wagyu of the pork sector.

Linton Batt supplies a boutique market with his Berkshire pork, which he says competes on flavour.

(Supplied: Linton Batt)

Linton Batt supplies a boutique market with his Berkshire pork, which he says competes on flavour.

"Our production is aimed at a very small niche; it's a domestic market for super premium pork," he said.

"We've done the numbers, and we know that we need a price premium for our production.

"There is only a small market of people who will pay that price but for us, we're small enough to fill that gap, along with some other excellent Berkshire breeders, and it's worth doing."

Mr Batt said in order for his operation, and his pigs' genetics to survive, he is careful to keep the business viable but is concerned about the agricultural sector losing genetics.

"It should be a concern for everybody; we're seeing gene pools shrink and the loss of diversity," he said.

"We're always looking at the numbers to make sure they are viable and that the business stands on its own merit."

Tina the Wessex saddleback pig. Her breed is listed as "at risk" of extinction by the Rare Breeds Trust of Australia.

(ABC Hobart: Damien Peck)

Tina the Wessex saddleback pig. Her breed is listed as "at risk" of extinction by the Rare Breeds Trust of Australia.

Dr Gressier said the Rare Breeds Trust of Australia had a comprehensive list of animals lost, critical, endangered, or vulnerable.

It lists six breeds of sheep as lost, four of pigs, and 10 of cattle.

"In Australia we used to have a really diverse dairy industry with a number of breeds producing milk," she said.

"Now it's about 70 per cent Holstein which produce milk in the kinds of volumes of scale required to meet market demands.

"Chickens are also faring really poorly, particularly meat birds.

"There are very few farmers who are managing to commercially produce meat chickens that aren't the Ross or the Cobb breed."

Dr Gressier is about to lead a UWA-based study of rare breeds being farmed across Australia to understand why farmers stick with rare breed farming and how their work can be better supported.

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Expert Reveals 3 Best Healthy Aging Tips – Medical Daily

Posted: December 9, 2019 at 4:50 am

A New York Times bestselling author of five books and easily recognized as a trailblazer in functional and integrative medicine, youd think Dr. Frank Lipmans philosophy on health aging will be quite the journal entry, sprawling into different facets that all explore a branch, all intertwining like a spiders web in order to achieve prime aging.

To our surprise, its not. In fact, it couldnt be simpler.

"Basically, eat less, laugh more, deal with your stress, take sleep seriously. What else would be important?" Dr. Lipman said in a recent podcast.

However, while he definitely has the formula down when it comes to aging gracefully, Dr. Lipman recently said that hes fascinated with our current pursuits to prolong our health, and not just our lives.

As such, he commented on it, saying that we should be aware of increasing our health span, not our life span.

So, how do you do it? Here are his tips, according to a recent post on mindbodygreen.

Physical adversity is the way to go

According to Dr. Lipman, a little bit of stress is actually good for you, which should come in the form of physical adversity such as fasting and high-intensity exercise. The idea is that your body is stressed a little bit to stimulate longevity genes, which then teaches your body to handle bigger stressors better. But dont starve yourself because the idea is that a little goes a long way.

Move intentionally

This isnt just about exercising more, although thats always a good idea. Per Dr. Lipman, this is about exercising intentionally and intelligently. The key, according to him, is to push your body in an intentional way that would test it but not enough to cause injury. Its harder to recover as you get older, and so its important to change the way you do your routines to better suit your body.

Dont take life too seriously

The last piece of advice, per Dr. Lipman, is to simply not take life too seriously and have some fun. These days, everyone is too caught up with numbers and metrics that its easy to forget how to enjoy things while were at it. Eat less and laugh more. Your life would be all the more better.

The Centers for Disease Control and Prevention (CDC) estimates that every 19 minutes an older adult dies from a fall in any part of the country. Pixabay

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Transcendental Meditation with Cardiac Rehab Can Increases Blood Flow to Heart – PsychCentral.com

Posted: December 9, 2019 at 4:50 am

A new study found that patients with coronary heart disease who included Transcendental Meditation with their cardiac rehabilitation increased blood flow to the heart by more than 20 percent.

The pilot study, conducted by researchers at Columbia University Irving Medical Center in collaboration with the Institute for Prevention Research, included 56 patients who had coronary heart disease, including a recent heart attack, coronary artery bypass, or angina.

This was the first study to show that the cardiovascular benefits of lifestyle modification, such as structured exercise and dietary counseling, may be enhanced by adding Transcendental Meditation in patients with heart disease, said Robert Schneider, M..D, F.A.C.C., co-director of the study and medical director of the Institute for Prevention Research. It also found that the Transcendental Meditation technique alone was able to reverse the effects of coronary heart disease assessed by positron emission tomography (PET) imaging.

For the study, the researchers randomly divided the subjects into four groups: cardiac rehabilitation, Transcendental Meditation, Transcendental Meditation plus cardiac rehabilitation, or usual care.

The studys findings showed that of the 37 patients who completed post-testing, myocardial blood flow increased by 20.7 percent in the group that did both Transcendental Meditation and cardiac rehabilitation. Blood flow in the group that practiced Transcendental Meditation alone increased 12.8 percent. Cardiac rehabilitation by itself showed an improvement of 5.8 percent. And patients who received the usual treatment showed a decrease in blood flow of -10.3 percent.

Although this is a preliminary study, it suggests that managing ones mind-body connection with Transcendental Meditation can improve the function of the heart in cardiovascular patients, said Schneider, who is also dean of Maharishi University of Managements College of Integrative Medicine.

He said that psychosocial stress is known to be a risk factor for coronary heart disease, but that stress reduction therapies arent usually included in cardiac rehabilitation.

More research needs to be done, but this study and previous research strongly suggest that medical professionals should consider utilizing this simple yet effective mind-body intervention in their heart health treatment and prevention programs, Schneider said.

While its not known precisely how Transcendental Meditation would increase blood flow, the researchers speculate that its a result of improved endothelial-mediated coronary and arteriolar vasomotor function. They explain that reduced levels of stress hormones and possibly inflammation may result in improved function of the endothelial cells that line the coronary arteries.

While the study suggests that the Transcendental Meditation technique can increase blood flow in cardiovascular patients, the researchers say that carefully conducted clinical trials with larger sample sizes are needed to confirm the benefit.

This was a first pilot study designed to determine the size of the effect and feasibility, Schneider said. Of the 56 original subjects, only 37 were available for the final post testing of blood flow after the 12-week study period. In addition, compliance with cardiac rehabilitation was average, with attendance at exercise sessions about 60 percent. Also, the subjects practicing Transcendental Meditation may have received more attention than the rehabilitation group. This initial study paves the way for full-scale clinical trials that will more rigorously evaluate these effects.

The study was published in the Journal of Nuclear Cardiology.

Source: Maharishi University of Management

Photo: Cardiac PET scan machine used in the cardiac rehabilitation study with and without TM at Columbia University Irving Medical Center. Credit: Columbia University Irving Medical Center.

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