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Almost a THIRD of doctors and nurses are not ‘confident enough to advise patients on sun protection’ – Denton Daily

Posted: November 26, 2019 at 6:47 pm

Almost a third of doctors and nurses do not feel confident enough on sun safety to advise their patients on how to avoid harmful UV rays, research suggests.

A study of more than 1,500 medics in the US found just under 30 per cent do not believe they have the knowledge to keep the public sun safe.

As a result, less than half of those surveyed regularly advise their patients to wear sunscreen, sit in the shade and avoid tanning beds.

Scientists from the Centers for Disease Control and Prevention warn most skin cancer cases come about due to UV rays from the sun or indoor tanning.

Nearly five million adults are treated for skin cancer every year in the US, the researchers wrote in the journal Preventative Medicine.

And in the UK, there were 15,970 diagnoses of melanoma, the deadliest form of the disease, between 2014 and 2016, Cancer Research UK statistics show.

There has been a recent push in the US for doctors to promote skin cancer prevention and sun safe behaviours, the researchers wrote.

The latter includes using sunscreen, wearing protective clothing, sitting in the shade and staying indoors at midday, which is when UV rays are typically at their most intense.

In 2012, the US Prevention Services Task Force (USPSTF) released its first set of recommendations on clinical counseling on skin cancer prevention.

Sunburn increases a persons risk of skin cancer.

It can happen abroad or in the UK.

To stay sun safe, experts recommend people:

Source:

The researchers, led by the behavioural scientist Dawn Holman, set out to uncover how many doctors in the US advise their patients on sun safety.

They analysed data from the online 2016 survey DocStyles.

This includes information on skin cancer prevention counseling practices for 1,506 GPs, internists, paediatricians and nurses.

Results revealed just under 30 per cent of those surveyed do not feel confident in their ability to provide advice about sun protection.

As a result, less than half (48.5 per cent) of the medics regularly advise their patients on sun safety.

And only just more than a quarter (27.4 per cent) recommend people avoid indoor tanning.

Of those who do give out advice, most only counsel patients with fair skin.

While people with pale complexions, light hair and freckles are more at risk of skin cancer, people with darker skin tones can also burn and develop the disease, the researchers warned.

The results further revealed most UV advice centres on wearing sunscreen, ditching sunbeds, avoiding the midday sun and wearing protective clothing.

However, the medics were less likely to advise patients to seek shade and check the UV index. This identifies the strength of the suns radiation at a given place on a particular day.

The researchers stress providing a range of sun safety options allows patients to find an approach that fits their preferences and activities.

The study also found the medics were more likely to give advice if they had been practicing for more than 16 years, had treated sunburn in the past 12 months or were familiar with theUSPSTF guidelines.

Barriers to counseling included a lack of time (58.1 per cent), more urgent concerns (49.1 per cent) and patient disinterest (46.3 per cent).

To overcome the time issue, future studies should look for ways of engaging other members of the medical team, such as health educators, in counseling efforts, the researchers added.

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Dallas Cowboys Battle the Flu Ahead of Their Biggest Game of the Year in Chilly New England – Newsweek

Posted: November 26, 2019 at 6:47 pm

The biggest game of the season looms this weekend for the Dallas Cowboys. But as they get ready to travel north and east to face the New England Patriots, many Cowboys players have been down and out with the flu.

Temperatures are expected to be in the low 40s at kickoff with rain and snow in the forecast. Some Cowboys players are getting past the flu, some are in the beginning stages and quarterback Dak Prescott is taking preventative medications, according to Calvin Watkins, beat writer for The Dallas Morning News.

"Flu bug has swept the Cowboys this week," Watkins tweeted. "Joe Thomas and Ben Bloom have it. Justin March has a respiratory infection, Jordan Lewis and Xavier Woods just recovered from it. Cowboys gave Dak Prescott some medicine as a precaution for any issues."

The Dallas Cowboys are 6-4 on the season, but none of their wins have come against teams with a winning record. Only the Philadelphia Eagles are among the teams they have beaten that don't have a losing record, as they are 5-5.

The Patriots are 9-1 and hold the best record in the AFC. Led by quarterback Tom brady, the Patriots have won 21-consecutive games in Foxborough, Massachusetts.

With six games remaining in regular season and holding just a one-game lead over the Eagles, every game is importantand beating the Patriots would give Dallas not only a much-needed win to stay ahead, but beating New England would likely give them a push through the final stretch toward the playoffs.

"I just think it's important to lock in on the task at hand every week. The best teams are able to do that," Cowboys coach Jason Garrett said in another Morning News report. "It's one day of preparation for that week's ballgame. That's what we try to instill around here. We don't do a lot of reflecting during the year on signature wins or this kind of a win or that kind of a win."

The schedule does not get easier for the Cowboys after their trip to New England. They host a 7-3 Buffalo Bills squad on Thanksgiving Day, and then travel to face the 4-6 Chicago Bears that allow just 17 points a game.

The Cowboys finish the last three regular-season games with the Los Angeles Rams (6-4), who was last year's NFC champion, at Philadelphia for perhaps the NFC East title on the line, and the Washington Redskins at home.

Then there's Dallas quarterback Dak Prescott, having his best season so far as a professional. Prescott has passed for 3,221 yards and 21 touchdowns in 10 games, including 444 yards last week against the Lions. He is on ace to surpass the 5,000-yard mark this season, which has never been done in Dallas' illustrious history.

Prescott has been given the flu preventative medication before the upcoming New England trip. Now is time for the travel, time change and temperature drop before kickoff.

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Remodeled Winn-Dixie opens in Zephyrhills, and other Pasco business news – Tampa Bay Times

Posted: November 26, 2019 at 6:47 pm

Briefs

WINN-DIXIE REOPENS: Winn-Dixie reopened its remodeled store at 36348 State Road 54 in Zephyrhills on Nov. 3. The store includes an updated farm-fresh produce department, improved deli with expanded grab-and-go meals and wing bar, upgraded meat case and floral department, and a new Dollar Shop section.

LOCAL ECONOMIC DEVELOPMENT PRESIDENT NAMED TO INTERNATIONAL COUNCIL: The Board of Directors of the International Economic Development Council has elected Bill Cronin, president and CEO of the Pasco Economic Development Council, to serve on its board of directors. The nomination took place during the International EDCs 2019 conference in Indianapolis Oct. 13-16. Cronins term begins Jan. 1.

BABY ITEMS DRIVE: Butash and Donovan Law is hosting a Baby Stuff Drive through the end of November at its office at 23554 State Road 54, Lutz. The drive is to benefit GuidingStar of Tampa, a womens healthcare practice offering medical and educational services, as well as ongoing support for women. Items needed include: gently used or new baby clothing for boys and girls, sizes newborn to 4T; newborn diapers; baby wipes, baby shampoo, baby soap and other toiletries; gently used maternity clothes; and small- and medium-sized stuffed animals. For information, call (813) 341-2232.

GRAND RE-OPENING OF HOSPITAL WOUND CARE CENTER: Regional Medical Center Bayonet Point held a grand re-opening of its Wound Care and Hyperbaric Medicine Center on Nov. 13. The center underwent a $500,000 renovation that took six months and included renovations of everything from podiatry chairs to updating all the furniture. Hyperbaric chambers were added, and the wound care center has been expanded to two suites, totaling 3,865 square feet.

HOSPITAL NAMES NEW CHIEF MEDICAL OFFICER: Medical Center of Trinity has appointed William Bill Killinger, MD, as its new chief medical officer. Dr. Killinger is a third-generation Florida physician. He was trained in cardiothoracic surgery, and was in private practice for 27 years in Raleigh, N.C. He is completing work on his healthcare executive masters degree with Brandeis University.

NEW DQ GRILL & CHILL OPENS: American Dairy Queen Corporation announced its new DQ Grill and Chill restaurant has opened in Hudson, at 14671 State Road 52. The restaurant is owned by Carlos and Pam Saenz. The Saenzes have been owners of a DQ Grill and Chill since 2016, with their first location in Land O Lakes. Carlos served five years in the U.S. Air Force, and still serves as a Reservist. Pam is also an elementary school teacher.

ALARM COMPANY MOVES TO PASCO: AFA Protective Systems recently relocated to a 5,800-square-foot facility in the West Pasco Industrial Park off State Road 54 in Odessa. The company designs, installs and monitors fire, safety and security systems.

CARES NAMES NEW DIRECTOR: Community Aging and Retirement Services (CARES) has named Melissa Kehler its new director of community engagement. Kehler has more than 20 years experience in nonprofit leadership roles, most recently serving as executive director of Chinsegut Hill Retreat and Museum in Hernando County.

HEALTH SEMINAR: AdventHealth will host a seminar, Treating Pain without Pills, from noon to 1 p.m. Dec. 3 at AdventHealth Zephyrhills, 7050 Gall Blvd. The speaker is Kamal Patel, MD, a fellowship-trained pain specialist who is double-board certified in preventative and occupational medicine. Reservations are required. RSVP to 877-534-3108.

HOLIDAY PARADE: The Greater Pasco Chamber of Commerce will host its 43rd-annual Holiday Parade on Dec. 14. The deadline for sponsorships and to enter a company float is Dec. 3. For details, contact the Chamber at (727) 842-7651.

Trinity Positive Business Network: 8:30 a.m. Mondays at Oasis Coffee Spot, 9213 Little Road, New Port Richey. Call Kelly Steen at (813) 388-8726.

Womens Connection of New Port Richey: 11:30 a.m. the second Monday of each month (September through May) at Spartan Manor, 6121 Massachusetts Ave., New Port Richey. Cost is $15 and includes lunch and a speaker. To RSVP, call Linda at (727) 856-4042 or Betty, (727) 807-6760.

BNI Overachievers Chapter: 7 to 9 a.m. Wednesdays at Myrtle Lake Baptist Church, 2017 Reigler Road, Land O Lakes. Call (813) 317-5556 or visit facebook.com/bnioverachievers.

BNI Outlook to Success: 7:30 a.m. Tuesdays at Verizon Event Center, 8718 Trouble Creek Road, New Port Richey. Cost is $10 and includes breakfast. Call (727) 815-7744.

Suncoast Women in Networking: 11:30 a.m. to 1 p.m. the third Tuesday of each month at Beef O Bradys, 5546 Main St., New Port Richey. Suncoast WIN is a group of professional businesswomen. Membership is $10 per year. Call Linda McFarland at (727) 863-6151.

Rotary Club of Lutz: 11:45 a.m. to 1 p.m. Tuesdays at Heritage Harbor Golf and Country Club, 19502 Heritage Harbor Parkway, Lutz. Cost is $12, includes lunch and speaker. Call (813) 857-7089 or visit lutzrotary.org.

West Pasco Business Association: Monday Lunch Chapter, noon to 1 p.m. Mondays, Johnny Bruscos, 10730 State Road 54, Trinity. Tuesday Breakfast Chapter, 8:30 to 9:30 p.m. at Hampton Inn, 1780 State Road 54, Odessa. Tuesday After Hours Chapter, 5:30 to 6:30 p.m. Tuesdays, FlameStone Grill Trinity, 10900 State Road 54, Trinity. Thursday Lunch Chapter, noon to 1 p.m. Thursdays, Giovannis Fresh Italian Kitchen, 37611 U.S. 19, Palm Harbor. Friday Breakfast Chapter, 8:30 to 9:30 a.m. Fridays at the Oasis Coffee Spot, 9213 Little Road, New Port Richey. The group is made up of professionals who promote each others businesses. Each chapter is seat-specific. Contact Maria Johnson, maria@wpba.biz or (727) 934-0940. Visit wpba.biz.

Coffee First: 8 to 9 a.m. the fourth Tuesday of the month at First National Bank of Pasco, 23613 State Road 54, Lutz. The event is hosted by the Central Pasco Chamber of Commerce in partnership with First National Bank of Pasco. Free and open to the public. (813) 607-2555.

East Pasco Networking Group: 7:30 p.m. the second and fourth Tuesdays of the month at IHOP, 13100 U.S. 301, Dade City. Annual dues are $25. Nils Lenz, (813) 782-9491.

Trinity Business Association: 6 to 7:30 p.m. the first and third Tuesdays of each month at Fox Hollow Country Club, 10050 Robert Trent Jones Parkway. Networking begins at 5:30 p.m., meeting starts at 6 p.m. Guests welcome. Cost is $12. Call Ginny Pierce at (727) 433-4073.

BNI Platinum: 7:15 a.m. Wednesdays at Heritage Harbor Golf & Country Club, 19502 Heritage Harbor Parkway, Lutz. Call Bob Nixon at (813) 263-5632.

Pasco Business Connections: 7:30 a.m. Wednesdays at the Broken Yolk, 3350 Grand Blvd., Holiday. Email noworries@tampabay.rr.com.

Wednesday Morning Networking Group: 7:30 a.m. the first Wednesday of each month at Hungry Harrys Family Bar-B-Que, 3116 Land O Lakes Blvd. A short networking presentation will be followed by a chance for all attendees to do a 30-second commercial. Cost is $7 in advance for members, $10 for guests, and includes breakfast. Call the Central Pasco Chamber of Commerce at (813) 909-2722.

Keep It Local-Trinity Chapter: 8 a.m. Wednesdays at Havana Dreamers Cafe, 3104 Town Ave., Trinity. (813) 405-7815.

Pasco Aging Network: 8 to 10 a.m. the second Wednesday of each month. Location changes each month. For information or to RSVP, visit pascoagingnetwork.org. PAN is a coalition of agencies and private providers of elder services in Pasco.

Keep It Local-Wesley Chapel Chapter: 8:30 a.m. Wednesdays at Lexington Oaks Golf & Country Club, 26133 Lexington Oaks Blvd., Wesley Chapel. (813) 405-7815.

Keep It Local-Christian Womens Network Chapter: 9:30 a.m. Wednesdays at the Direction Connection, 2632 U.S. 19, Holiday. (813) 405-7815.

Free Networking International: 11:30 a.m. to 1 p.m. Wednesdays at Cantina Laredo, 2000 Piazza Ave., Building 4, Suite 170, Wesley Chapel (at the Shops at Wiregrass). Attendees pay for their own lunch. Call Martine Duncan at (813) 929-6816.

Keep It Local-New Port Richey Chapter: 11:30 a.m. Wednesdays at the Direction Connection, 2632 U.S. 19, Holiday. (813) 405-7815.

Keep It Local-Odessa/Trinity Chapter: 11:30 a.m. Wednesdays at Seven Springs Golf & Country Club, 3535 Trophy Blvd., Trinity. (813) 405-7815.

BNI Eagles: 7:15 a.m. Thursdays at Spartan Manor, 6121 Massachusetts Ave., New Port Richey. Cost is $10 and includes breakfast. Call Clay Henderson at (727) 534-5191.

BNI Referral Connection: 7:15 to 9 a.m. Thursdays at Vallartas Mexican Restaurant, 22948 State Road 54, Lutz. Call Rob Hamilton at (813) 431-5887.

Christian Business Connections of Central Pasco: 7:45 to 9:15 a.m. Thursdays at Quail Hollow Golf Club, 6225 Old Pasco Road, Wesley Chapel. Cost of $9 per meeting, includes breakfast and beverages. Annual membership dues are $100. Call Rene Van Hout at (813) 300-7511.

Trinity/West Pasco Chapter of NPI: 7:45 a.m. Thursdays at The Grand Plaza Caf, 4040 Little Road, New Port Richey. Call Rob Marlowe at (727) 847-2424.

Networking For Your Success: 8 a.m. Thursdays at Lexington Oaks Country Club, 2615 Lexington Oaks Blvd., Wesley Chapel. Cost is $5 and includes a continental breakfast. Annual membership is $79. Call Matt at (813) 782-1777.

Women-n-Charge: 11:30 a.m. on the first Friday of each month, Plantation Palms Golf Club, 23253 Plantation Palms Blvd., Land O Lakes. The cost is $15 for members and $18 for guests who RSVP by Monday prior to the meeting. Tuesday and after, the cost is $20 for members and $23 for guests. To RSVP, visit women-n-charge.com/meetings/. For information, call Judy at (813) 600-9848.

Women of Wesley Chapel (WOW): 7:30 to 9 a.m. first Friday of each month, Beach House Assisted Living and Memory Care at Wiregrass Ranch, 30070 State Road 56, Wesley Chapel. WOW is the North Tampa Bay Chamber of Commerces women only networking group. The cost is $5, includes breakfast and networking. To RSVP, call (813) 994-8534 or email office@northtampabaychamber.com.

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Guest Opinion: Trump’s Title X gag rule is detrimental to HIV/AIDS health care – Bay Area Reporter, America’s highest circulation LGBT newspaper

Posted: November 26, 2019 at 6:47 pm

by Gray Gautereaux

Tuesday Nov 26, 2019

President Donald Trump. Photo: Courtesy ABC News

During his 2019 State of the Union address President Donald Trump revealed his administration's new 10-year plan to "end the HIV epidemic in America", with a goal of reducing diagnosis rates to less than 3,000 per year. The plan is ambitious and calls for the diagnosis of all people with HIV/AIDS as quickly as possible. Unfortunately, the Trump administration has already actively subverted these goals through to implementation of a 2017 gag rule on Title X family planning that effectively withdrew $600 million in global health assistance and prohibited supplemental funds to domestic providers that recommend or provide abortion services. But, as is often the case in American abortion policy, the withholding of these funds intended to curb abortion rates include extensive and detrimental impacts on a wide variety of community health services including access to HIV and cancer screenings by underprivileged communities.

Conceived by Congress in the 1970s, Title X was originally influenced by President Richard Nixon's promise to enhance women's access to family planning. Title X is the sole federal program committed to providing family planning, contraceptive, and preventative health services. Title X has proved to be integral in making health care more accessible to millions of low-income Americans. According to an Elsevier study published last year, one-third of publicly funded clinics in the United States receive money through the national Title X family planning program. The same study reports "six in 10 women (61%) visiting Title X-funded clinics for contraceptive and related services report that the clinic is their usual source for medical care." These data are especially significant to HIV/AIDS prevention efforts as 2016 data () from the Department of Health and Human Services revealed "one in five new HIV diagnoses in the United States are women. Women of color, especially black/African American women, are disproportionately affected by HIV infection compared with women of other races/ethnicities."

Gray Gautereaux. Photo: Courtesy Gray Gautereaux

Title X-funded clinics are required to provide, at minimum, HIV/AIDS testing, either on site or by referral, as well as prevention education. Title X clinics have also been integral to increasing access of at-risk populations to pre-exposure prophylaxis, or PrEP, a daily medicine that reduces at-risk patients' chances of contracting the disease. Initiatives to extend access of Title X clinics have been pushed by both the Centers for Disease Control and Prevention and HHS since 2016, but the gag rule has already become a barrier for policy- and research-based accessibility initiatives.

The gag rule has caused a tidal wave effect as health care providers opt to withdraw from Title X funding rather than compromise their values in providing a full range of options to patients seeking pregnancy counseling. Since the implementation of the ban, seven state governments, as well as Planned Parenthood, have elected to withdraw from the Title X program and a number of other clinics nationwide have been forced to close their doors as they face mounting legal and financial barriers to providing affordable health to low-income areas. As a result, America is now plagued with regional droughts in minority patients access to general community health provisions. A September report from Kaiser Health News found that, as of 2019, "nearly 80% of the rural U.S. has been designated as 'medically underserved,'" meaning about 20% of Americans may not have access to a health care provider for hundreds or thousands of miles. And the options left over from the wave of Title X withdrawals has left a vacuum that the Trump administration has been filling with a very specific and ineffective form of clinic.

As more and more clinics withdraw from the Title X funding program, those that remain have tended to harbor a striking similarity: religious affiliation and abstinence-only family planning policies. A writer for Mother Jones, Stephanie Mencimer, published an investigative report () this year on how the Trump administration has begun channeling Title X funds into anti-abortion clinics run by Christian pregnancy centers. One of these centers, a Southern California-based chain called Obria, was awarded $5.1 million in Title X funds in March to provide contraception and family planning services to low-income women over three years. But Mencimer's investigation revealed "Obria's founder is opposed to all FDA-approved forms of birth control and has privately reassured anti-abortion donors that Obria will never dispense contraception, even as she has aggressively sought federal funding that requires exactly those services." Not exactly a prime environment to maximize health providers ability to "diagnose HIV as early as possible" as the Trump administration now proposes to do.

Given the obvious limitation forced upon providers and communities by the gag rule, the executive administration's efforts to end the HIV epidemic are unrealistic and insensitive of the limitations they have set which are already limiting patients access to their normal avenues of health care. If HIV/AIDS diagnoses are to be reduced to levels that effectively end the epidemic it is obvious the Title X gag rule must be acknowledged for what it is a pawn in the political game of abortion rights that goes too far and works against the interest of the policy's intent. In addition, while integral to the political and medical vitality of Americans, abortion policy needs to be teased apart from general health issues by both the left and right to prevent a type of collateral damage that contributes to increases subpar levels of medical accessibility for millions of Americans. The gag rule in conjunction with the "Ending the HIV Epidemic: A Plan for America" initiative is a trivializing contradiction of policies that flaunts goals of aiding public health while simultaneously undercutting the means to serve those most in need. While it is unlikely the Trump administration will revoke the rule it will be imperative for health providers and political constituencies to demand and organize the resources they need- the future of health for millions of Americans is on the line.

Gray Gautereaux is a senior at Willamette University in Salem, Oregon and is a recipient of one of the Pedro Zamora Young Leaders scholarships awarded by the National AIDS Memorial Grove.

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Keeping the Radio City Rockettes on their toes, with help from Westchester – Lohud

Posted: November 26, 2019 at 6:47 pm

A look at the Radio City Rockettes training room with Elaine Winslow-Redmond, Director of Athletic Training and Wellness for the Rockettes, and Dr. Melody Hrubes of Rothman Orthopedic Institute, the Rockettes' new medical director, Nov. 18, 2019 at Radio City Music Hall in Manhattan. Tania Savayan, tsavayan@lohud.com

On a Monday afternoon, just days before opening night, Emily King, 22, a Radio City Rockette, dropped by an office at Radio City Music Hall.

King, who is in her second season as one of the famed dancers, came to see Dr. MelodyHrubes, the new medical director for the Rockettes, andElaine Winslow-Redmond,the director of athletic training, for a consultation.

It just provides a lot of security for us as performers," King said. "We know that if anything goes wrong, like they have our back and they are going to provide help where it's necessary.

November 6, 2019: Dress rehearsal for the Radio City Christmas Spectacular starring the Radio City Rockettes.(Photo: Zack Lane, Zack Lane/MSG Photos)

King,who is from Michigan and has a bachelor's degree in Commercial Dance from Pace University,is one of 80Rockettesknown for their signature eye-high kicks and a precisiondance technique that requires both artistry and athleticism.

Hrubes and Winslow-Redmond make surethe Rockettes are in top shape as they ascend the Radio City Music Hall stage multiple times a day to perform the Christmas Spectacular.

Dr. Melody Hrubes of Rothman Orthopaedic Institute, left, the Radio City Rockettes' new medical director, and Elaine Winslow-Redmond, Director of Athletic Training and Wellness for the Rockettes, give Rockette Emily King a pre-screening Nov. 18, 2019 at Radio City Music Hall in Manhattan.(Photo: Tania Savayan/The Journal News)

While they range in height from 5-foot-6 to 5-10, the dancers succeed in creating the illusion that they are kicking at the same height through a combination of formation (tallest woman in the center) and technique.

They perform up to 16 times a week and can kick up to 650 times a day. Each 90-minute performance requires 160 kicks in high heels.Theunforgiving routine can put considerable strain on their bodies.

For Hrubes, that means preventing injuries before they happen.

Elaine Winslow-Redmond, Director of Athletic Training and Wellness for the Radio City Rockettes, left, talks about the program as Dr. Melody Hrubes of Rothman Orthopaedic Institute, the Rockettes' new medical director, looks on Nov. 18, 2019 at Radio City Music Hall in Manhattan.(Photo: Tania Savayan/The Journal News)

What is so interesting to me about dance is that it's choreographed, so there's a lot of biomechanical and overuse injuries that happen, said Hrubes, who practices with RothmanOrthopedic Institute, which opened a location in Harrison last month and is the official provider of orthopedic services to the Rockettes.

That's why we're so interested in how to prevent that, since they're doing the same thing over and over again.

October 22, 2019: The Radio City Rockettes rehearse for the Christmas Spectacular at the St. Paul the Apostle Church in New York City.(Photo: Carl Scheffel, Carl Scheffel/MSG Photos)

A lot of what she sees with the Rockettes also applies to other athletes, said Hrubes, a specialist in sports medicine who has previously worked as a team physician for the United States Soccer Federation and with United States Gymnastics.

A lot of young athletes aren't taught to listen to their bodies;they think that if there's no pain, theres no gain. If I'm hurting, that means I'm just working hard enough, said Hrubes, talking about injury prevention. And actually pain is your body's way of saying something is wrong. So learning the difference between soreness and pain is super valuable because then they could actually learn to listen to their bodies.

Dr. Melody Hrubes of Rothman Orthopaedic Institute, left, the Radio City Rockettes' new medical director, and Elaine Winslow-Redmond, Director of Athletic Training and Wellness for the Rockettes, give Rockette Emily King a pre-screening Nov. 18, 2019 at Radio City Music Hall in Manhattan.(Photo: Tania Savayan/The Journal News)

That philosophy dovetailswith what Buchanan resident Winslow-Redmond has sought to do with the Rockettes since 2005.

A former Rockette who performed for 11 seasonsfrom 1994-2005,Winslow-Redmond said she was frustrated when, in her first season,she sought treatment for a shin splint a kind of stress fractureand found doctors who didnt fully understand what she did.

They would say things like, 'There's no hopping in tap dancing.' And I thought to myself, I don't think they understand what I do if they don't think I'm hopping while I'm tap dancing, she said."They didn't understand that I needed to stay in the show. I couldn't like just take a few weeks off.

November 7, 2018: Dress rehearsal for the upcoming Radio City Christmas Spectacular at Radio City Music Hall in New York City.(Photo: Carl Scheffel, Carl Scheffel/MSG Photos)

She was eventually helped byan athletic trainerwho taught Winslow-Redmond how to prevent injury through her next 10 seasons. And she learned firsthand how important it is to focus on recovery after a show.

So I had great longevity and I was able to dance injury free for the rest of my seasons, she said.

Winslow-Redmond said she was bothered by the fact that the Rockettes didnt have an in-house trainer or doctor. So, whilecontinuing to dance as a Rockette, Winslow-Redmond, who hasa bachelor's in dance, took advantage of a tuition assistance program available to Rockettes to transition to other careers.

She got masters in physiology and nutrition at Columbia University and eventually became the Rockettes' trainer in 2005.

As part of herthesis, she analyzed five years worth of Rockette injury reports andshowed that the majoritywere preventable overuse injuries.

"Overall the choreography has gotten more difficult," she said. "So as we're challenging the Rockettes and they're rising to a higher level, their injuries are decreasing. Theres been a 78% decrease in injury. So that's the impact.

Her advice for current and aspiring dancers?

They should pair their dance training to incorporate a strength element so that they strengthen the muscles that tend to be weak on dancers.

She also emphasizes recovery. I push hard on recovery because I really understand the impact of many shows in one week," she said. Understanding the level of fatigue that I experienced and being able to teach them the necessary steps on how to recover and that pushing through is not always the way to go.

Rockette Emily King in the athletic training and wellness room at Radio City Music Hall Nov. 18, 2019 in Manhattan.(Photo: Tania Savayan/The Journal News)

For Rockette Emily King, working with Winslow-Redmond and Hrubeshas been helpful. Just in a preventative sense, the pre-screening is so helpful," she said. "They give us exercises to help prevent injuries that are specific to us, like things that we are susceptible to, which is incredible.

Dr. Hrubes and Winslow-Redmond offered advice for athletes on preventing injury:

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Swapna Venugopal Ramaswamy covers women and power for the USA Today Network Northeast. Write to her at svenugop@lohud.com

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electroCore to Present at the Two December Investor Conferences – Yahoo Finance

Posted: November 26, 2019 at 6:47 pm

BASKING RIDGE, N.J., Nov. 26, 2019 (GLOBE NEWSWIRE) -- electroCore, Inc. (ECOR), a commercial-stage bioelectronic medicine company, today announced that Dan Goldberger, Chief Executive Officer, will present a corporate overview and host investor meetings at the Evercore ISI HealthCONx Conference 2019, taking place December 2-4, 2019 at Four Seasons Hotel in Boston, Massachusetts, and the LD Micro 12th Annual Main Event conference, taking place December 10-12, 2019 at the Luxe Sunset in Bel-Air, California.

About electroCore, Inc.

electroCore, Inc. is a commercial stage bioelectronic medicine company dedicated to improving patient outcomes through its platform non-invasive vagus nerve stimulation therapy initially focused on the treatment of multiple conditions in neurology and rheumatology. The companys current indications are for the preventative treatment of cluster headache and acute treatment of migraine and episodic cluster headache.

For more information, visit http://www.electrocore.com.

Investors:

Hans VitzthumLifeSci Advisors617-430-7578hans@lifesciadvisors.com

or

Media Contact:

Sara ZelkovicLifeSci Public Relations646-876-4933sara@lifescipublicrelations.com

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electroCore to Present at the Two December Investor Conferences - Yahoo Finance

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Treating ‘suicidality’ as its own medical condition could spur research, better treatment options – Genetic Literacy Project

Posted: November 26, 2019 at 6:47 pm

One night in her Nashville apartment, Bre Banks read a comment from her boyfriend on Facebook. They were in a shaky spell, and his words seemed proof she would lose him. She put her laptop down on the couch and headed to the bedroom to cry. My legs seized up, and I fell, she recalled. With her knees and forehead pressing into the carpet, she heard a voice that said, Slit your wrists, slit your wrists. She saw herself in the bathtub with the blood flowing. She was terrified that if she moved she would die.

Banks, then 25, was a disciplined graduate student with a job and close friends and had no psychiatric history. I had never considered suicide an option, she says. But for the next three days, she couldnt sleep while the voice and disturbing images persisted. After seeing a therapist, she decided to teach herself techniques from dialectical behavior therapy, one of the few treatments shown to reduce suicidality. The voices and images came back over the next few months, but eventually faded. Eight years later, Banks now evaluates suicide prevention programs across Tennessee as a manager at the large mental health provider Centerstones research institute, and she and the same boyfriend just celebrated their 10th anniversary.

In the public imagination, suicide is often understood as the end of a torturous decline caused by depression or another mental illness. But clinicians and researchers know that suicidal crises frequently come on rapidly, escalating from impulse to action within a day, hours, or just minutes. Many also point to the fact that they may strike people like Banks, who are otherwise in good mental health.

That understanding is one reason a movement is building to define suicidality as a condition in its own right. Most recently, researchers from Mount Sinai Beth Israel and Florida State University have agreed to collaborate on a joint proposal for a new diagnosis in the next Diagnostic Statistical Manual of Mental Disorders (DSM), a handbook published by the American Psychiatric Association. The criteria include familiar symptoms of depression, but these symptoms occur in an acute state that is not currently obvious to clinicians. Proponents say it could spur more research and make it easier for suicidal patients to get the care they need.

Suicide rates have been rising sharply since 1999, figures from the Centers for Disease Control and Prevention (CDC) show. More than half of those who take their lives do not have a known mental health condition. There is also no established way to pinpoint when a patient is in immediate danger. You cannot rely on people telling you when they are or are not suicidal, said Igor Galynker, a professor of psychiatry at Icahn School of Medicine in New York.Some have expressed skepticism. Far too many diagnoses in psychiatry come and go, said George Makari, a Weill Cornell Medicine psychiatrist and historian of psychiatry. The idea that suicidality may not be a symptom of something else a mood or personality disorder is novel. If theyre making the claim that weve been seeing this upside down for a long time, he said, thats fascinating.

Research backs that up: A 2019meta-analysisof 71 studies conducted around the globe found that about 60 percent of people who died by suicide had denied having suicidal thoughts when asked by a psychiatrist or general practitioner. Here in the U.S., a2016 studyexamined data from four health systems that use standardized questionnaires in primary care and specialty clinics. (The questionnaires ask whether the patient has experienced thoughts that you would be better off dead or of hurting yourself in some way.) Although the answers did predict future suicide attempts to some extent, there were plenty of false negatives. Thirty-nine percent of the suicide attempts and 36 percent of the suicide deaths occurred among patients who had responded not at all to the key question. In another study, about a quarter of the suicide attempts were made by people who reported zero suicidal thoughts.

Its easy to assume they were lying, but thats not quite true. Greg Simon, a psychiatrist and investigator at Kaiser Permanente Washington in Seattle, who led the 2016 study, was involved in a follow-up study based on interviews with 26 people who had made attempts after denying any suicidal thoughts on the standard questionnaire. The interviews revealed that some people had lied, he said. But they also revealed people who had provided aspirational responses they weretryingnot to have suicidal thoughts and people who had experienced no suicidal thinking whatsoever. (Among the latter group, alcohol often factored into their attempts.) None of them woke up that morning with a plan to die that day.

For his part, Galynker determined long ago after he lost a patient who took him by surprise that he couldnt rely on patient reports. In 2007, he set out to develop a set of symptoms that would help pinpoint imminent suicide even if the patient didnt report suicidal thinking. We hypothesized that the pre-suicidal state leading to suicidal action was short-lived, kind of like pulling a gun trigger, he said. In 2009, he called it suicide trigger state. Over dozens of research papers, he explored various symptoms as predictors, developing checklists and then testing how well they predicted future behavior. While these checklists are still new, they are being used to screen for suicidal risk among high school students in Moscow, Russia, and among hospital patients in Chicago.

In 2017, Galynker coined the termsuicide crisis syndrome. People with this syndrome feel trapped, though they might not think of death per se. They may be flooded with misery and unable to think clearly. Certain thoughts, like Banks images and voices, return repeatedly, no matter how much they are resisted. They may experience mood swings or overwhelming emotional pain.

At Florida State University, Thomas Joiner, the author of several books on suicide and the editor of a suicide journal, outlined his own criteria for a quick-onset suicide crisis, which he calls acute suicidal affective disturbance. This describes rapidly escalating plans for suicide over hours or days faster than clinicians may expect. The key difference is that Joiner includes reports of suicidal thinking as an essential criterion.

The pair teamed up more than two years ago when the first paper describing both of their diagnoses appeared. Together, the two researchers envision a new DSM suicide diagnosis with two sub-types, one with thoughts of suicide, and one without. Before this diagnosis is approved for the DSM, however, the researchers may need to show more conclusively that the phenomenon they describe isnt a symptom of depression or another mental illness, and that their methods of screening for it are effective.

Psychiatrist Michael First at Columbia University, who presided over earlier revisions of the DSM, sees a suicide-specific diagnosis as an appealing idea. If the melding of Galynkers and Joiners formulations worked well and proved to be accurate, First said, then it would clearly be very useful to have it.

Clinicianscurrently struggle with little guidance on how to identify imminent risk or make sense of suicides that seem to come out of the blue.

Nearly once a week, attending psychiatrist Dmitriy Gekhman at Mount Sinai Beth Israel sees a patient who has attempted suicide and is hard to classify, though he must find a relevant code for each patients chart. You kind of go through the history and everything, and theyre not depressed. They dont meet the criteria for depression, they dont meet criteria for bipolar disorder, and they dont have a personality disorder, he said. We just discharged somebody this week who that happened to, and we still have somebody on the unit now.

If a diagnosis based on Galynkers and Joiners research were put in place, it would put the patients doctors on notice that the patient is a risk for suicide with rapid onset. Over time, its possible that clinicians and even teachers and parents would become better at seeing the signs. The diagnosis, Joiner explained, is a warning sign for the future.

Detroits Henry Ford Health System provides a glimpse of how suicide prevention might evolve. At Henry Ford, suicide is considered its own mental health category, not primarily a symptom of depression. In 2002, the health system began a series of initiatives, and reduced patient suicide rates a dramatic 80 percent over the next seven years.

The staff at Henry Ford discovered that from 2000 to 2010, only half of patients who died by suicide had received a mental health diagnosis, closely matching current national statistics. This could be undiagnosed illness, but I think a lot of people dont meet the criteria, said Brian Ahmedani, who directs the health systems Center for Health Policy & Health Services Research.

Henry Ford screens everyone with questionnaires asking about suicidal thoughts, a practice the Joint Commission, which certifies health care organizations, started recommending in 2016. But in its behavioral health units, the risk assessment focuses on triggers, such as a job loss. Ahmedani says that patients in the highest risk percentile usually have a number of triggers: chronic pain, opioid use, and insomnia, for example. Because assessing the many possible combinations can be difficult, Henry Ford uses artificial intelligence to analyze electronic medical records, helping clinicians who may not have time to catch a perfect storm before its already too late. Veterans are a high-risk group, so the Veterans Affairs (VA) has begun using these algorithms too.

Currently, suicidal people are often prescribed antidepressants. However, other than lithium, most often used to treat people with bipolar disorder, theres little evidence that medication prevents suicide, Ahmedani observed. New VA clinical guidelines alsosupportshort-term infusions of a drug calledketamine.

Henry Ford offers treatments specific to suicide: identifying triggers and coping mechanisms, for example. It also offers cognitive behavioral therapy and dialectical behavior therapy, the treatment that helped Banks. Patients are encouraged to develop a safety plan that includes removing guns or painkillers from the home, and an idea of who they might call under duress.

David Covington, a suicide prevention activist, said, we used to think that if you treat addiction, the mental health will get better, and the other side thought if you treat mental health, the addiction will get better. Now we say you have to treat both. Similarly, a person might need treatment for both suicide and depression.

The new diagnosis, more fundamentally, could change who we think might be driven to the extreme of a suicide attempt. Psychiatrists still refer to suicide attempts with a short buildup as impulsive, but Joiners team disputes that these are impulsive people. Megan Rogers, a Ph.D. candidate who works with Joiner, sees outpatients at the university clinic. She recalls one who within hours would go from no risk to high risk but had what she describes as a conscientious and vigilant, rather than impulsive, personality.

Still, some question whether a new diagnosis would actually benefit patients. For one thing, it isnt clear how such a diagnosis would influence treatment or whether it would save lives. There is simply no value in a prediction that cannot lead to an effective preventative measure, writes psychiatrist Matthew Large in a2018 paperevaluating suicide assessment approaches generally. More people could land in hospital psychiatric care, or be kept longer than they desire, he said. And while it is generally assumed that hospitalization can prevent suicide, this has never been demonstrated empirically. In fact, suicide rates are high among recently discharged patients and some say hospitalization can make things worse.

Galynker agrees that hospitalization is not necessarily the answer and is looking at new treatment methods. In the meantime, the diagnosis might communicate the higher risk to insurance companies, explained Lisa Cohen, a professor of psychiatry at Icahn School of Medicine and co-author with Galynker, giving patients better access to treatment options.

Psychiatrists who make decisions about hospitalization say they would appreciate more science to guide them. It would be incredibly helpful to have a very clear indication that someone is at higher risk, observed Julie Holland, who once presided over a psychiatric emergency room at Bellevue Hospital in New York. A close look at the buildup to a crisis would be invaluable. We do that when somebodys heart stops, or when somebodys heart is imminently stopping, said Chicago psychiatrist Leo Weinstein, who teaches at Northwestern University. Making the unstable state a diagnostic entity in its own right, like ventricular fibrillation or congestive heart failure, he says, is crucially important.

Temma Ehrenfeld is a writer and ghostwriter in New York drawn to philosophy and psychiatry. Her most recent book is Morgan: The Wizard of Kew Gardens. Follow her on Twitter @temmaehrenfeld

A version of this article was originally published on Undarks website as Can a New Diagnosis Help Prevent Suicide? and has been republished here with permission.

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A New Frontier in Family Health and History – The Nation Newspaper

Posted: November 26, 2019 at 6:47 pm

Heritable diseases that are passed down through the generations have been known for quite some time. For most of that time though, people had no idea why it was this way, let alone what to do about it. This all changed with the arrival of DNA sequencing from the completion of the Human Genome Project over a decade ago.

Not only do people recognize that genes can play a factor in the likelihood of contracting certain ailments, but increasingly scientists are able to pinpoint where these genes are, how they are contributing to something, and to formulate a solution.

The Importance of HealthIt is not enough that people are living longer lives if those extra years are spent in a hospital bed. What really matters is not how many years you spend on this Earth, but how many healthy years. This is why the subject of health is so important. Health can be said to be the key to a truly fulfilling life.

As we age, our body accumulates more flaws and as a result we become less vigorous over the years, generally speaking. But if we take care of our health when we are young, we can slow this process down by quite a bit. There are a good number of retirees who have done this and are reaping the benefits.

In the days of old, most knowledge people had of maintaining good health was traditions passed down over the generations. This of course is not always perfect as some traditions might not be rooted in the best of science. Some traditions might be outright harmful to family and societal health.

The health of one person can potentially affect the entire family. If someone falls ill, the whole family is wrought with worry anxiety because a loved one is in distress. If it turns out to be something major, like cancer, not only is the familys emotions dragged down, but potentially their finances as well.

The miracle of modern technology is the gift that does not stop giving. With genealogy and heritage DNA tests available to the public, families might just be able to save a members life just by knowing more of something. Through knowledge and preventative medicine, people are being empowered to take matters of life into their own hands. While this of course means that a greater degree of personal responsibility is needed, this also means that we can make better decisions on what to do with our life simply because we now know more about ourselves.

As with many things, modern technology always has the potential to lend a helping hand. In the past couple centuries, human life expectancy has actually doubled worldwide! Improved sanitation, mass vaccination and germ theory have all contributed to this rise in life expectancy.

Another truly remarkable achievement has been the dramatic drop in infant mortality. Just a few short centuries ago, two in five children did not reach the age of five. In most developed countries, this has dropped to less than one in a hundred. This has resulted in the elimination of suffering for nearly countless families worldwide.

With the discovery of the double helix structure of DNA, scientists were able to confirm that certain gene expressions contributed to the rise of certain ailments and also that some of these expressions were transmitted from parent to child. And through better understanding of these gene expressions, scientists will be able to better combat these diseases.

With the Genome Project completed, the field transformed into an information technology and was able to ride the exponential wave of IT development along with countless other fields that have been swept by the IT fairy. Now, scientists are able to attack the problem of heritable diseases with even more pinpoint precision.

DNA Kit testing has exploded in popularity in recent years. With technology making everything cheaper, DNA testing kits are now within financial reach of millions of families. Some people use this technology to satisfy certain curiosities while for others, it could very well be a lifesaver.

DNA testing kits work by sending a testing kit to your address with instructions on what they need from you, usually a large saliva sample, as well as how to get it back to them. After a certain amount of time, some documents will be mailed back to you documenting their findings.

There are some DNA testing kits that specialize in looking for heritable traits with real world consequences such as predispositions to certain heritable diseases and even certain allergies. Many of us go around our daily activities not even slightly aware that we have certain predispositions we have no control over.

This can be very helpful because a DNA test might produce information that can be applied to a real-life medical situation. If you have a high chance of contracting a certain disease than most, it might make sense to take action now that might save your life and spare your family from suffering a loss in the family.

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The Bedpan: ‘The problem with conceding to Simon Stevens’ – Health Service Journal

Posted: November 26, 2019 at 6:47 pm

Why it matters: The latest deep dive by Britains leading political historian examines Theresa Mays time as prime minister and details how her attitude and approach to the NHS changed during her time in Number 10.

Theresa May didnt understand what had gone wrong [on the NHS] or how to put it right when she entered Number 10, according to Sir Anthony Seldon.

She was instinctively anti-reform because she knew previous attempts had backfired, while at the same time hyper-sensitive to the possibility of a winter crisis.

Sir Anthony also claims she did want to see increased funding for the NHS, something that will surprise those senior NHS figures who met with her at this time.

Indeed, her first budget in 2017 only produced a 2.8bn increase for the NHS, despite the PMs own policy unit and NHS England chief executive Simon Stevens arguing for 4bn.

Sir Anthony quotes Mrs May as saying: The problem with conceding to what Simon Stevens is always demanding is that we end up putting the money into short-term solutions like reducing waiting lists rather than systematic improvement, or into preventative medicine or mental health.

Then health secretary Jeremy Hunt apparently agreed with the PM.

The settlement ended up riling the NHS rather than pleasing them recalls special adviser Alex Dawson.

However, towards the end of the year, Mrs Mays attitudes had begun to change.

The PM felt the Conservatives had got into a ridiculous position on the NHS as a result of being banned from discussing it by campaign guru Lynton Crosby during the 2015 and 2017 elections.

NHS performance was continuing to worsen, Mr Stevens was again growing vocal and House of Commons health select committee chair Sarah Wollaston began to call for a Royal Commission, which scared No10 and No11 witless.

On 7 February 2018, Mrs May was shown polling by Mr Dawson which demonstrated that people were prepared to pay extra taxes to fund improvements to the NHS.

Sir Anthony becomes a little too credulous at this point, taking at face value statements like the PM started to think that the NHS leadership needed to be treated in the same way as the police: it needed reform to become much more biddable.

There had been a plan to announce an inquiry into the NHS at the end of 2016, similar to the one conducted into higher education, but this had been overruled by the Treasury, says Sir Anthony.

Now the idea was reheated as a 10-year NHS Plan.

This would apparently enable Number 10 to hold the NHS to account for delivery.

The truth as most HSJ readers will know is that by 2018 the government had little choice but to significantly increase NHS funding or face a total service melt-down and the resulting political backlash. Chancellor Philip Hammond tried to hold out for a three-year settlement, but finally accepted it had to be five.

The NHS plan full of good ideas as it is was still sophisticated window dressing for dragging the NHS out of the traditional public sector spending round to be given a 70th birthday present. A fact instantly recognised by savvy commentators like Spectator editor Fraser Nelson, who was both admiring of the conjuring trick pulled off by Mr Stevens and Mr Hunt and, irritated that the spoilt NHS could get even more cash.

From the start of Mrs Mays premiership, Sir Anthony says mental health was an area in which she was prepared to take risks. He claims Mrs May won an 18-month battle from 2012 with Mr Hunt to get David Camerons government to take mental health more seriously.

Mrs May arranged for Sir Simon Wessely, former president of the Royal College of Psychiatrists, and Poppy Jaman, founder of Mental Health First Aid, to address Cabinet for 45 minutes.

Most ministers were attentive, apart from foreign secretary Boris Johnson who gave the impression that he thought it was all nanny-state stuff and made sotto voce asides throughout.

No surprise then that, according to Sir Anthony, those working on a subsequent project to improve black, Asian and minority ethnic mental health did their best to make it Boris proof.

Sir Simon is glowing in his praise for Mrs Mays interest in and support for the most intractable aspect of mental health, one in which there were the fewest votes: severe mental illness. Nobody since Stephen Dorrell, Conservative health secretary between 1995 and 1997, had taken such a real interest in the most difficult part of the whole spectrum, the former Royal College of Psychiatristspresident tells Sir Anthony.

Perhaps the most illuminating section of the book is the one on the disaster which befell Mrs Mays proposed social care reforms in 2017.

Here was an issue on which according to Number 10 deputy chief of policy Will Tanner Mrs May believed people felt let down by politicians and that it was her duty to act.

Her senior communications adviser Fiona Hill told the PM it was a mistake, but Sir Anthony quotes Mrs May as saying: I know Ill have to use up some of my political capital, but this is the time to do it.

As Ms Hill rowed with Mrs Mays other chief adviser Nick Timothy, the PM with tears in her eyes banged the desk and said: Were going to do this.

When as Ms Hill predicted the negative media coverage of the social care proposals provoked widespread panic among Tory MPs, Mrs May did nothing to calm the storm.

Sir Anthony notes she simply could have said: Nobody would lose their homes during their lifetime and they would be left with at least 100,000. But she didnt and, as Sir Anthony remarks later in the book, as far as Mrs May was concerned social care was dead in the water.

One intriguing side note was that the first draft of the 2017 Conservative manifesto contained a proposal to introduce social insurance. Mrs May vetoed it, saying over my dead body.

The section on the January 2018s botched reshuffle confirms Mrs May had intended to replace Mr Hunt with the solid Greg Clark to calm things down after the junior doctors strike. However, Sir Anthony has also discovered that Mr Hunt had spoken to No10 before the general election about wanting to be moved, and that rumours swirled in the corridors of power that he wanted the job of deputy prime minister.

As that possibility receded, Mr Hunt began to change his mind, without notifying Number 10. He was, recounts May at 10, increasingly keen on becoming the longest-serving health secretary in history something, of course, he achieved in due course.

If there is any political or influential figure you would likeHSJto interview, please emailalastair.mclellan@wilmingtonhealthcare.com.

The past five Bedpans

Will Hutton

Cardiac Arrest and Bodies writer Jed Mercurio

The Grenfell Tower fire

Margaret Thatcher and the birth of the internal market

Doctors for Extinction Rebellion

You can read all 44 Bedpanshere

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ViiV Healthcare announces exclusive licensing agreement with the National Institutes of Health for investigational bNAb with potential for long-acting…

Posted: November 26, 2019 at 6:46 pm

LONDON--(BUSINESS WIRE)--ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Pfizer Inc. and Shionogi Limited as shareholders, today announced that the company will be developing the investigational broadly neutralising antibody (bNAb) N6LS for the treatment and prevention of HIV-1, as part of an exclusive licensing agreement between GSK and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

Broadly neutralising antibodies are antibodies that can recognise and block the entry of different strains of HIV into healthy cells. N6LS is an antiviral bNAb that works by binding to a specific site (gp120) on the surface of HIV that prevents its entry into uninfected immune system cells (CD4+ T-cells). By blocking HIVs entry into human CD4+ cells, HIV replication is halted, and the HIV transmission process may be prevented.1

Kimberly Smith, M.D., Head of Research & Development at ViiV Healthcare, said: We are excited to advance N6LS from its current proof of concept stage to the next step in its development by studying this bNAb as a long-acting medicine that could potentially be used for both treatment and prevention of HIV. By continuing to research new ways that people living with HIV can reach undetectable viral loads, we build on our ten-year history of furthering innovative science in HIV and take another important step forward in ending the epidemic.

ViiV Healthcare looks forward to initiating a phase IIa study with material manufactured by the NIAID Vaccine Research Center that will evaluate the efficacy, safety, tolerability, and pharmacokinetic profile of N6LS in adults living with HIV.

Additional details about N6LSN6LS was originally discovered and developed by scientists at NIAIDs Laboratory of Immunoregulation and VRC. NIH and GSK entered into a Cooperative Research and Development Agreement (CRADA) to jointly identify and further develop new bNAbs such as N6LS that could serve as the next generation of treatment regimens for people living with HIV and preventative options for HIV transmission. This exclusive license outlines a programme for ViiV Healthcares development of N6LS as well as milestone payments and royalties to the NIAID.

About ViiV HealthcareViiV Healthcare is a global specialist HIV company established in November 2009 by GlaxoSmithKline (LSE: GSK) and Pfizer (NYSE: PFE) dedicated to delivering advances in treatment and care for people living with HIV and for people who are at risk of becoming infected with HIV. Shionogi joined in October 2012. The companys aim is to take a deeper and broader interest in HIV/AIDS than any company has done before and take a new approach to deliver effective and innovative medicines for HIV treatment and prevention, as well as support communities affected by HIV.

For more information on the company, its management, portfolio, pipeline and commitment, please visit http://www.viivhealthcare.com.

About GSKGSK is a science-led global healthcare company with a special purpose: to help people do more, feel better, live longer. For further information please visit http://www.gsk.com.

_____________________1 Kumar R, Qureshi H, Deshpande S, Bhattacharya J. Broadly neutralizing antibodies in HIV-1 treatment and prevention. Ther Adv Vaccines Immunother. 2018;6(4):6168.

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