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Could cytotoxic T cells be the key to longevity? Daily science – Up News Info

Posted: November 14, 2019 at 12:41 pm

Scientists at the RIKEN Center for Integrative Medical Science (IMS) and the Keio University School of Medicine in Japan have used single-cell RNA analysis to discover that supercentenarians, that is, people over 110, have a excess of a type of cell immunity called cytotoxic CD4 T cells. Supercentenarians are something like a unique group of people. First, they are extremely rare. For example, in Japan in 2015 there were more than 61,000 people over 100 years old, but only 146 over 110 years old. And studies have found that these individuals were relatively immune to diseases such as infections and cancer throughout their lives. This led to the idea that they could have a particularly strong immune system, and the researchers set out to find out what could explain this.

To answer the question, they analyzed the circulating immune cells of a group of younger supercentenarians and controls. They acquired a total of 41,208 cells from seven supercentenarians (an average of 5,887 per subject) and 19,994 cells for controls (an average of 3,999 per subject) from five controls between 50 and 80 years old. They discovered that while the number of B cells was lower in the supercentenarians, the number of T cells was approximately the same and, in particular, the number of a subset of T cells increased in the supercentenarians. When analyzing these cells, the authors discovered that the supercentenarians had a very high level of cells that are cytotoxic, which means they can kill other cells, which sometimes represent 80 percent of all T cells, compared to just the 10 or 20 percent in controls. .

Normally, T cells with markers known as CD8 are cytotoxic, and those with the CD4 marker are not, so the authors first thought that perhaps CD8 positive cells increased. But that was not the case. Rather, it seems that the supercentennial CD4 positive cells had acquired the cytotoxic state. Interestingly, when the researchers looked at the blood of young donors, there were relatively few cytotoxic cells positive for CD4, indicating that this was not a marker of youth but a special characteristic of supercentenarians. To see how these special cells were produced, the team examined the blood cells of two supercentenarians in detail and discovered that they had emerged from a clonal expansion process, which means that many of the cells were the progeny of a single ancestral cell.

According to Kosuke Hashimoto of IMS, the first author of the article, "We were especially interested in studying this group of people, because we consider them to be a good model of healthy aging, and this is important in societies such as Japan, where aging is proceeding quickly. "

IMS Deputy Director Piero Carninci, one of the group leaders, says: "This research shows how transcription analysis of individual cells can help us understand how individuals are more or less susceptible to disease. CD4 positive cells they generally work by generating cytokines. " , while CD8 positive cells are cytotoxic, and it may be that the combination of these two characteristics allows these individuals to be especially healthy. We believe that these types of cells, which are relatively uncommon in most individuals, even young people, are useful for fighting established tumors, and could be important for immunovigilance. This is exciting, as it has given us new ideas on how people living very long lives can protect themselves from conditions like infections and cancer. "

The research, published in Proceedings of the National Academy of Sciences (PNAS), was carried out by a collaboration that includes scientists from the RIKEN Center for Integrative Medical Sciences and the Faculty of Medicine of the University of Keio.

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Music Therapy Builds a Bridge over Troubled Water for Patients at UH Geauga and Portage Medical Centers – The Weekly Villager

Posted: November 14, 2019 at 12:41 pm

Geauga & Portage Counties Most people know that listening to music or playing an instrument can make them feel calm, happy or even inspired. At University Hospitals Connor Integrative Health Network, board-certified music therapist Forrest Paquin taps into that power to make a difference in patients emotional and physical wellbeing.

Paquin, who holds a bachelors degree in music therapy from Bostons renowned Berklee College of Music, brings music to some 150 patients a month at UH Geauga and Portage medical centers. She works with a diverse range of patients, using music as a therapeutic tool to decrease their perception of pain and stress.

Music therapy is an evidence-based practice, Paquin explained. Numerous studies have proven music therapy to be an effective tool in managing pain and stress for patients with various medical problems and conditions in the acute-care setting. Some of the types of patients with whom she has worked include patients with cancer or behavioral health problems and those going through respiratory therapy, heart or orthopedic surgery and those in hospice.

Although Paquin is an accomplished musician who sings and plays guitar, violin and percussion, the beauty of music therapy is that patients dont need to have music skills or talent, she said. Using music in medicine is not about performance. There is no judgement, she said. Its a therapeutic tool for patients to express themselves in a positive way, verbally and nonverbally, while enhancing their quality of life.

Music therapy interventions can be designed to promote wellness, improve communication, manage stress, alleviate pain or enhance memory and self-expression, she said. She usually starts a session by talking with the patient about the kinds of music he or she likes, essential information for meeting each patients needs. She develops an assessment for each patient and measures his or her stress and pain levels and physical and emotional conditions before and after each music therapy session.

Paquin makes her rounds at the hospitals with a custom music therapy cart that includes an assortment of instruments, a keyboard and a mini-recording studio. Singing, playing an instrument and listening to music can engage the patient socially and be a positive outlet for coping with stress related to a diagnosis or hospitalization, she noted. For others, music diverts their pain perception by giving them something else to focus on.

Paquin joined UH Connor Integrative Health Network in 2017 and developed the music therapy programs at UH Geauga and Portage medical centers. She and ten other board-certified UH music therapists are part of the UH Connor Integrative Health Network, which provides alternative, non-pharmacologic therapies such as music therapy, art therapy, acupuncture and guided imagery. Seidman Cancer Center at UH Geauga Medical Center currently is seeking donations from the community that will support expansion of these therapies for cancer patients.

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Akesis Life: Cancer clinic in Thailand – Treatment Abroad

Posted: November 14, 2019 at 12:41 pm

"; images = images + ""; images = images + ""; images = images + ""; images = images + ""; images = images + ""; images = images + ""; images = images + ""; jQuery('.imgGallery').prepend(images); jQuery('.each_image:first').show()}function navigateSliderNext(){coutner_img = parseInt(jQuery('#thecnt0').html());counter_img++;if(counter_img>total_img){counter_img=1}jQuery('#thecnt0').html(counter_img);jQuery('.each_image').hide()jQuery('.each_image[id="is'+counter_img+'"]').show()}function navigateSliderPrev(){coutner_img = parseInt(jQuery('#thecnt0').html());counter_img--;if(counter_imgAbout Akesis Life

Based in Bangkok, Thailand, Akesis Life is a state-of-the-art integrative oncology centre offering a targeted, effective and kind approach to treating cancer based on enhancing the patients own ability to heal. Using an extensive variety of proven therapies designed to treat the root cause of the cancer and rebuild health, immunity and awareness, the Centres mission is that patients leave them not only cancer-free, but also with a better quality of life.

The goal of integrative oncology is to heal from cancer rather than conquer it. Unlike conventional treatments that kill cancer cells with collateral damage to the body and the immune system, Akesis Lifes non-toxic, non-invasive programme stops the spread of cancer, eliminates cancer cells without damaging healthy cells and increases the bodys immune system thereby providing an environment which prevents the cancer from returning.

Akesis Lifes integrative approach puts the whole person at the centre of the healing programme, rather than the disease itself. During a residential stay of 8-12 weeks, patients are guided and supported with expert medical care to understand the root causes of their cancer and the fundamentals of living a healthy life. In this way, patients are always active participants in their personalised healing journey.

The medical team at Akesis Life is made up of two leading practitioners in the field of integrative medicine, Dr Thomas Lodi and Dr Chatchai Sribundit.They are supported by a caring and experienced team, including a health chef and a renowned holistic innovator, who together ensure that a patients experience is as comfortable and rewarding as it can be.

The Akesis Life Medical Centre houses their renowned oncology medical team with access to the latest advanced technologies in non-toxic cancer treatment.To ensure the highest levels of personalised care, the Centre treats no more than 15 patients at a time who stay within the 5 star complex.

Facilities and amenities at the Akesis Life Medical Centre are more in keeping with a resort than a hospital and include a range of luxurious accommodation options, large outdoor pools, a modern gym, private dining area, yoga and meditation room, recreation room, lounge and library, and classroom for lectures and workshops.

Akesis Life offer treatment for all types of cancer including breast cancer, lung cancer, pancreatic cancer, colon and rectal cancer, lymphomas, leukaemia, liver cancer, brain cancer, ovarian cancer and skin cancers.

The Akesis treatment programme is based on three fundamentals: stop making cancer; target cancer without harming the body; activate and enhance the immune system.

Tools to kill or eliminate cancer such as surgery, chemotherapy and radiation have no effect on cancer stem cells, meaning that in all but a few rare situations the cancer returns. At Akesis, the focus is on changing the biochemical environment of the body so that it ceases to be a good host to cancer. This is achieved by incorporating the following into the treatment programme:

Akesis offer the latest metabolic therapies that safely and effectively eliminate cancer cells without damage to healthy cells, tissues and organs. Treatments available include:

Enhancing the immune system is vital to successful cancer treatment as the most important strategy that cancer cells employ in order to survive is to inactive and block the immune system. The biochemistry involved in immunosuppression by cancer cells is extremely complex. With this in mind, Akesis Life has developed an immune programme that reactivates the immune system in a specific sequence using the following treatments:

Akesis Life take care of all aspects of a trip to Thailand for cancer treatment, from initial phone call and video consultation through to help with travel arrangements and aftercare, ensuring a seamless and stress-free experience.

To learn more about their treatment programmes, call their friendly team on 66 (0) 655 896 964 or complete the online contact form.

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Weight Loss: This Is The First Step Towards Achieving Fat Loss And Good Health – Doctor NDTV

Posted: November 14, 2019 at 12:41 pm

Weight loss tips: Introspection is the first step on your weight loss journey. Read here to know how introspecting the duration and cause of weight gain and can help you lose weight in a healthy manner.

Tips for weight loss: Fat loss can be achieved by setting realistic goals for yourself

What is the first step towards weight loss and achieving good health? According to lifestyle coach Luke Coutinho, the first focus should be on fat loss achieved in a healthy way. Quick weight loss comes with several side effects like premature ageing of skin, weak immunity, thin, dry and dull hair to name a few. Thus, the first step towards fat loss and achieving good health is introspection-you should be aware of what you eat, the exercise you do and how it reflecting on your body and overall health.

When it comes to introspection, you need to ask yourself how long it took you to gain weight. Having figured out how long it took you to gain weight, ask yourself if you can lose that weight in a month, 6 months or 1 year?

For weight gain that happened over a period of 6 months or 1 year, losing that weight cannot happen in 1 or 2 months, says Luke in his live video session on Facebook.

Also read:Weight Management: 5 Practical Ways To Avoid Weight Gain

Setting a realistic target for yourself is the healthy way to lose weight, fat and gain good health. Setting unrealistic or too difficult to achieve targets for yourself can cause anxiety, frustration, disappointment and stress-which in turn can make you put on more weight.

After giving yourself realistic goals, you need to find out what made you put on that weight. It can be because of stress, overeating, partying too much, being sleep deprived, having high amounts of sugar or carbs, a new job that caused a change in lifestyle, being physically inactive or lack of exercise, etc. Doing this will make it easier for you to have an action plan for healthy and achievable weight loss.

A poor diet could be the reason behind your weight gainPhoto Credit: iStock

Work towards reducing or cutting down on the things that went wrong and caused you to gain weight.

The idea is to work on the causative factor of weight gain rather than only working on reducing weight.

Luke advises: Know your target and work only towards achieving that goal. There is no point in chasing a particular goal as it is only going to make you more anxious and gain weight instead.

Also read:Too Lazy To Workout During Winter? Do Not Compromise On Your Fitness Goals With These Weight Loss Tips

Sleep well to lose weight quickly and efficientlyPhoto Credit: iStock

The above steps, when followed with consistency, can together help you lose weight, fat and gain health. Let us know if this works for you.

Also read:7 Health Benefits Of Regular Exercise Other Than Weight Loss

(Luke Coutinho, Holistic Lifestyle Coach - Integrative Medicine)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Working hand in hand with the nation’s largest integrated care system – Penn: Office of University Communications

Posted: November 14, 2019 at 12:41 pm

The Veterans Administration has traditionally been an incubator for innovations that improve quality of life not only for veterans but also for civilian populations around the worldideas like bar-coding machines, or the discovery that daily aspirin cuts the rate of heart attacks for certain patient populations. For many years and in a range of capacities, Penns School of Nursing has been a close VA collaborator.

In 2011,for example, in addition to her role at Penn, palliative care professor Mary Ersek became director of the Veteran Experience Center, a national quality-improvement initiative housed at Philadelphias Corporal Michael J. Crescenz VA Medical Center. Rosemary Polomano, Penn Nursings associate dean for practice and a professor of pain practice, helped change the standard pain scale employed by the VA.

There are many examples of this partnership, with innovative solutions aimed at the largest integrated health system in the U.S. and the top employer of nurse practitioners, according to the Veterans Health Administration. Along the way, the VA has also built systems for tracking outcomes, leading to a treasure trove of data.

Its a great time for evidence-based research and training, saysCoy Smith, associate director of patient care services and nurse executive at the Philadelphia VA, as well as assistant dean for clinical practice at Penn Nursing. A lot of this work is transferrable to non-VA patients.

Here, a look at the work made possible because of the Veterans Health Administration-Penn Nursing collaboration.

Evidence-based health care practices are interventions based on the best, latest scientific findings. Penn sleep and health behavior researcher Amy Sawyer is currently leading 15 evidence-based quality improvement projects at the Philadelphia VA, on subjects like preventing injury in surgical patients and secondary traumatic stress in health care providers.

Change, no matter how you look at it, is hard, Sawyer says. Its hard to accept, and its hard to convey to others that change needs to happen. But implementing it can have real results, like with a recent occupational health project that involved switching the type of tuberculosis testing the VA used for incoming employees.

Unlike the standard test, called purified protein derivative or PPD, a newer test called T-SPOT.TB does not require a follow-up visit after 48 to 72 hours. During a PPD shortage two years ago, VA clinicians put in place the T-SPOT.TB procedure and followed it for a year. The program has since rolled out across the entire VA system, leading to a 29% increase in employee compliance, a 40% drop in costs, and a 50% reduction in time to clear new hires.

We used to think of quality improvement and research as separate, Ersek says. But over the years weve gotten more sophisticated. We use research methods. We sort of mimic, statistically, a randomized control trial.

To that end, Ersek and her team use the Bereaved Family Survey (BFS) in their VA work. The BFS, developed through a VA-funded research project and now used throughout the system, asks respondents to evaluate quality of care at the end of life. Its mailed to the next of kin of every veteran who dies at a VA facility or in one of several VA home-based primary care programs. Facility-level scores are calculated quarterly and sent to each facility. The Veteran Experience Center also works directly with care teams to help them interpret their scores and develop strategies to improve care and outcomes.

For example, we might identify chronically low scores on an overall item, as well as those related to communication for a specific facility, Ersek says. Training in family conferences might then follow. We continue to monitor their BFS scores during and following the training to see whether it had an impact on outcomes, she adds.

The survey is a unique way to keep a pulse on the quality of care at the VA for veterans and families, saysAnn Kutney-Lee, an adjunct associate professor of nursing who studies the effects of nursing care organizations on patient outcomes. We ask about communication with providers, whether their preferences were met for treatment, she says. We ask about emotional and spiritual support. Did they get the amount of support they wanted? Did they see a chaplain if they wanted one?

Veteran demographics are shifting from those who served in World War II and the Korean War to those who served in Vietnam. This has implications for end-of-life care, as veterans from the Vietnam era are more likely to have been exposed to dangerous combat situations, says Kutney-Lee. Many veterans were fighting in jungles and mountains; there were hidden explosives planted, all with a near-constant threat of being ambushed, she says. The nature of the direct combat situations was very different.

The way society welcomed them home was different, too. World War II vets were hailed as heroes, enjoying national support. Vietnam vets experienced the opposite, says Kutney-Lee. Things were thrown at them when they got off the planes. Today, they are less willing to talk about their experiences, something that can resurface, emotionally, at the end of life.

Its something Kutney-Lee and colleagues are trying to understand to better prepare health care providers to treat these vets. They are seeing higher rates of anxiety and post-traumatic stress, as well as more chronic illnesses that correlate with chemicals such as 2,4,5-T, an ingredient in the herbicide Agent Orange, to which many soldiers in Vietnam were exposed. In an effort to be proactive, the VAs Hospice and Palliative Care Program Office and the Veteran Experience Center are using the BFS and other data to create educational programs aimed at helping providers meet this groups unique end-of-life needs. We want the vets and their families experience to be as peaceful as possible, Kutney-Lee says.

She is involved in another project with Ersek andMargo Brooks Carthon, another Penn Nursing researcher, to study racial and ethnic disparities in quality end-of-life care for vets. Some of their work has found that the next of kin of African American vets were 50% less likely than other groups to report that their loved ones received excellent care at the end of life. The researchers want to know why.

One clue: Members of racial and ethnic minorities tend to be more sensitive to changes in nurse-staffing levels. The researchers hypothesize that in facilities where staffing is better, nurses are better positioned to meet the complex care needs of patients, which may also apply at the end of life. They have the resources they need and the time to spend with their patients, says Kutney-Lee.

Pain management entails a complex matrix of mind and body, which makes having a standard scale on which to measure pain crucial.

Penn Nursings Rosemary Polomano specializes in managing acute pain following combat-related injuries. After learning that clinicians in 28 facilities who used the standard numeric pain rating scale (0-10) found it inadequate to help patients and health care providers communicate about pain-intensity levels, Polomano collaborated with leaders from the Defense and Veterans Center for Integrative Pain Management and others to develop the Defense and Veterans Pain Rating Scale (DVPRS).

The scale integrates word anchors (from no pain to as bad as it could be, nothing else matters) with color-coding and facial expressions to help patients rate their pain.

According to Polomano, DVPRS is now the official military pain scale, with the goal of being used in all Department of Defense health care facilities. Other health systems are free to use it too, Polomano says. It is in the public domain.

Polomano also teachesPain Science and Practice, a class open to students from Penn Nursing, Penn Dental, and Penns Perelman School of Medicine. This year, in partnership with the Uniformed Services University Graduate School of Nursing in Bethesda, Maryland, 30 active-duty military personnel from their nurse anesthesia program attended the class.

Nurses work at the heart of the changes in veterans care and, therefore, help to shape the future of American health care. Much of the VAs innovative models of care delivery are due to the leadership and contributions of VA nurses, says David Shulkin, a Distinguished Health Policy Fellow at Penns Leonard Davis Institute of Health Economics and a former secretary of veterans affairs. Its often their affiliation with leading academic centers like Penn that help to ensure the VA remains at the forefront of these innovations.

Ive often felt that the VA is the best place for advanced practice nurses, saysPatricia DAntonio, the Carol E. Ware Professor in Mental Health Nursing and director of the Barbara Bates Center for the Study of the History of Nursing. One of the best jobs she says she ever had was working with VA nurses to identify and help patients with compelling emotional or psychological needs. One patient, an outgoing, lovable former boxer, would sometimes lash out and punch someone when he got upset. The VA nurses developed a plan to appoint him an unofficial nursing assistant. He followed a nurse around, carried water, etc. He had a job to do, says DAntonio. With a new sense of purpose, he could control his anger. No more punching.

Ersek was similarly drawn to the VAs work. Being involved in the military, thats a big honor. Our mission as care providers is not about prestige, she says. We get to use rigorous research methods, but I like that we stop and say its not just an academic exercise; its about using these advanced analytic methods to improve care for veterans.

That sense of purpose goes a long way. I havent practiced clinically at the VA since 1992, says DAntonio, but I still describe myself as a VA nurse. Its part of my identity. Thats true for many among the ranks of Penn Nursing faculty, who work hand in hand with the nations largest integrated care system treating a unique patient population thats changing every day.

A longer version of this feature, by Louis Greenstein, originally ran in the Spring 2019 issue of the Penn Nursing Magazine.

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NIA Mourns the Loss of Dr. Huber Warner – National Institute on Aging

Posted: November 13, 2019 at 12:46 pm

Huber R. Warner, Ph.D., a biochemist who led NIAs Biology of Aging Program, passed away suddenly on September 12 in St. Paul, Minn., at the age of 83.

Dr. Warner joined NIA in 1984 where he managed the Molecular Biology Program while also serving as chief, Biochemistry and Metabolism Branch. In January, 2000 he was named associate director of the NIA Biology of Aging Program. Warner played a large part in expanding the scope and scale of aging research at the NIA, while helping to mentor a new generation of scientists. His research interests included oxidative stress, molecular mechanisms of apoptosis, functional genomics and stem cells.

Huber was not only a well-respected scientist and leader in our field, but his gentle nature made him beloved by both the community and his colleagues, said Dr. Felipe Sierra, director of the NIA Division of Aging Biology (DAB).

Dr. Dick Sprott, Warners predecessor at the NIA DAB, said Dr. Warner served with diligence and great scientific acumen. While his insights were important for the biology of aging field, we will remember him for leadership and common sense. I, like many others, will always treasure his sound advice and friendship.

Dr. Richard Hodes, director of the NIA said The entire NIA family is saddened by the loss of Dr. Warner. He helped guide and grow the study of aging biology at the NIH and NIA with a steady hand and curious mind, and will be deeply missed.

Warner was born in 1936 in Glendale, Ohio. He received a doctorate in biochemistry from the University of Michigan in 1962, and following postdoctoral work at M.I.T., he joined the faculty of the Department of Biochemistry at the University of Minnesota, St. Paul, Minn., in 1964. He was a member of the American Society for Biochemistry and Molecular Biology and a Fellow of the Gerontological Society of America.

After leaving NIA in 2004, he returned to the University of Minnesota, where he served as associate dean of research until his retirement in 2010. He spent his later years at the Universitys independent living community, and returned often with family to his beloved Cawaja Beach in Ontario, Canada. Warner was known for his many athletic interests and as an enthusiastic volunteer coach for youth sports. He played hockey growing up, and tennis in his later years, and was a member of the NIH Tennis and Sailing clubs.

A memorial service celebrating Warner will be held on Saturday, November 16, at 1:00 p.m. at the University of Minnesota. He is survived by sons Geoffrey and Peter; daughter-in-law Dawn; and 3 granddaughters: Chloe, Laurel and Alexandra.

People interested in honoring Warner can make a tax-deductible donation to the "Huber Warner Fellowship in Molecular Biology, which supports a talented graduate student studying the mechanisms of aging. Donations can be made online or by sending a check to:

University of Minnesota Foundation200 Oak Street, SE, Suite 500Minneapolis, MN 55455-2010

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The Best Ways to Soothe a Sore Throat – Yahoo Lifestyle

Posted: November 13, 2019 at 12:45 pm

One of the more uncomfortable symptoms of a cold and one of the most common is a sore throat. What starts as an annoying scratch can worsen overnight, making simple tasks such as eating, drinking water and talking really painful. While you might not be able to rid yourself of pain entirely, there are a few things you can do to ease your discomfort.

Is It a Cold or the Flu? How to Tell the Difference

Gargle with salt waterGargling with salt water might seem like it would make things worse, but it could really help you feel better. The saltwater solution helps to reduce inflammation by drawing mucus out from your throat and calming swelling. To make the solution, simply combine a half-teaspoon of table salt in 8 ounces of warm water and stir until the salt dissolves. Then, gargle the solution for several seconds before spitting it out. You can repeat this throughout the day as needed.

Suck on a menthol-flavored lozengeThroat lozenges can help, too, for a few reasons. They contain menthol, which partially numbs the tissue in your throat. Additionally, they increase the amount of saliva in your mouth, which keeps your throat lubricated to prevent scraping.

Stay hydratedAbove all, when youre sick it is crucial to stay hydrated. When youre dehydrated, in addition to the other side effects of dehydration, your body cant produce enough saliva and mucus to keep your throat lubricated. This can worsen inflammation. Sip on water and other hydrating beverages all day long. In particular, you may want to try loading up on the best drinks to help fight the flu, which also work on fighting the common cold.

Drink warm tea with honeyDrinking a cup of warm tea mixed with honey can help to temporarily ease pain. The tea keeps you hydrated while also providing antioxidants, which can be anti-inflammatory and work to protect against damage from free radicals. Chamomile tea in particular, according to a review in Molecular Medicine Reports, helps to lubricate the throat and reduce inflammation. Adding a spoonful of honey can make this even more of an effective pain reliever. According to research published by Canadian Family Physician, honey can reduce throat discomfort in both children and adults. However, its crucial that you drink the tea warm, not hot. Drinking tea while its too hot will further irritate the area.

Hopefully with one of these remedies, you can feel a little better during your cold. After all, a sore throat is just one of the first symptoms youre likely to experience when you catch a cold.

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CIL Management Consultants enjoys growth in the US – Consulting.us

Posted: November 13, 2019 at 12:45 pm

CIL Management Consultants has enjoyed rapid growth in the US since it established its US team in Chicago a year ago. The growth has been driven by new mandates for market reviews, commercial due diligence, and corporate strategy engagements to support private equity and management teams across a range of sectors.

The team has trebled in size over the past year and as a result has moved to new offices at the Citadel Center in Chicago, which provides room to grow as the firm continues to recruit experienced consultants across all sectors.

Recent projects include vendor commercial due diligence to support Leeds Equity Partners (New York) sale of Project Management Academy to Morgan Stanley Capital Partners. Project Management Academy is a provider of training and exam preparation services for project management professionals.

CIL also provided commercial due diligence to support Five Arrows Capital Partners' (New York) investment in Virginia-based Averhealth, which provides drug testing and laboratory services. Averhealth serves more than 1,800 courts and probation services across 26 states in the US.

CIL also supported Fishawack Group's acquisition of Dudnyk, providing commercial due diligence. Fishawack, backed by LDC, provides communications services to the global pharmaceutical industry. Philadelphia-based Dudnyk is an advertising agency focused on rare disease, oncology, and molecular medicine.

The consulting firm hasalso supported clients with market studies and growth strategy support across a range of other areas, including gyms, testing and inspection services, and smart building technology.

Rebecca Pigula, Principal at CIL Management Consultants, commented: CIL has enjoyed an extremely successful first 12 months in the US, providing advice to clients across a range of sectors. As a result, we are building the team to ensure that we continue to deliver the excellent service and advice that is at the heart of our business.

In a market environment where competition for prize assets is increasingly fierce, our focus on private equity, understanding of investment considerations, evidence-driven approach, and deep sector insight are all aspects that have been well-received in the US. Were looking forward to supporting our growing number of US clients to acquire and maximize the success of their portfolio companies in the years to come.

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Dr. Nancy Brown named the Long Professor of Internal Medicine – Yale News

Posted: November 13, 2019 at 12:45 pm

Dr. Nancy Brown

Dr. Nancy J. Brown, recently appointed as the C.N.H. Long Professor of Internal Medicine, is an internationally renowned educator, investigator, and clinician. Her appointment will be effective Feb. 1, pending approval by the School of Medicine Board of Permanent Officers.

In September, Brown was named the next dean of the Yale School of Medicine. She will assume that post on Feb. 1.

A Yale College graduate, Brown is currently the Hugh Jackson Morgan Professor and chair of the Department of Medicine at Vanderbilt University.

Brown majored in molecular biophysics and biochemistry at Yale and earned her medical degree at Harvard University. After completing internship and residency programs at Vanderbilt University, she joined its faculty, engaging in both clinical care and research.

While taking on increased leadership responsibilities and mentoring scores of Vanderbilt students, residents, and fellows, Brown has led a research program in cardiovascular pharmacology, which has been continuously funded by the National Institutes of Health since 1993. Among her research contributions, she has defined the molecular mechanisms through which commonly prescribed blood pressure and diabetes drugs affect the risk of cardiovascular and kidney disease. She has continued to care for patients, especially those with resistant and secondary forms of hypertension, and to mentor the next generation of physician-scientists.

Since becoming leader of Vanderbilts Department of Medicine in 2010, Brown expanded mentorship resources for trainees and faculty members who concentrate on research and established a career development program for faculty members who focus on clinical work. During her tenure, there was an increase in the number of women and members of underrepresented groups in medicine, both on the faculty and in leadership positions.

Throughout her career, Brown has focused on medical education and mentoring career development. She founded and directed the Vanderbilt Master of Science in Clinical Investigation program to promote the advancement of patient-oriented researchers. She also developed the Elliot Newman Society to shorten time-to-independence for physician-scientists. She is an elected member of the Vanderbilt Academy for Excellence in Teaching and has received many mentorship awards.

Brown serves on a number of editorial boards and national and international scientific advisory committees, providing guidance on the development of research programs and educational initiatives. She has received numerous awards for her achievements, including election to the American Society for Clinical Investigation, the Association of American Physicians, and the National Academy of Medicine.

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$3.5M Grant Will Finance New Lines of Attack in the Battle Against Alzheimer’s Disease | | SBU News – Stony Brook News

Posted: November 13, 2019 at 12:45 pm

A new approach to combatting Alzheimers Disease will be pioneered by Donghui Zhu, Associate Professor in the Department of Biomedical Engineering and the Institute for Engineering-Driven Medicine, aided by a $3.5 million research grant from the National Institutes of Health.

According to Zhu, the molecular and cellular mechanism that causes Alzheimers Disease (AD) is still not fully understood. The risk factors underlying AD may include genetic background, environment, lifestyle and chemistry within the brain and body. One thing science does know is that neuroinflammation is a key risk factor in the development of AD. What is also known is that the essential element Magnesium (Mg) plays an important role in reducing inflammation in the human body.

We know that around age 60 individuals begin to experience reduced Mg levels and that perhaps as many as 75% of older people are Mg deficient, says Professor Zhu. This potential connection between Mg, inflammation and AD has been largely overlooked. Understanding the precise involvement of Mg and related inflammation in neurodegenerative diseases may uncover strategies that could evolve as new therapeutic targets for effective treatment of neuroinflammation, AD and other dementia.

The hypothesis is that Mg protects neurons by serving as an antioxidant to reduce oxidative stress (the imbalance between free radicals and antioxidants in the body), inflammation and synaptic loss. Professor Zhu began looking at this issue fifteen years ago while still in grad school. He was able to bring his expertise to Stony Brooks College of Engineering and Applied Sciences (CEAS) beginning with the 2019/2020 academic year through the SUNY Empire Innovation Program (EIP), a New York state competitive grant program dedicated to recruiting and retaining world-class faculty at the State University of New York.

The EIP program continues to be instrumental in enabling us to attract premier scientific talent at Stony Brook and CEAS, said Fotis Sotiropoulos, Dean, College of Engineering and Applied Sciences. In only a few short months with us, Don is already making a measurable impact on our College and on the battle against Alzheimers. I look forward to the results of this important and ground-breaking work as his research progresses.

Dick Wolfe

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$3.5M Grant Will Finance New Lines of Attack in the Battle Against Alzheimer's Disease | | SBU News - Stony Brook News

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