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Achieve Life Sciences Announces Granting of New Hire Inducement Award

Posted: January 29, 2023 at 1:02 am

SEATTLE, Wash and VANCOUVER, British Columbia, Jan. 27, 2023 (GLOBE NEWSWIRE) -- Achieve Life Sciences, Inc. (Nasdaq: ACHV), a late-stage pharmaceutical company committed to the global development and commercialization of cytisinicline for smoking cessation and nicotine addiction, today announced that the Company has issued an inducement grant of stock options to a new employee.

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Purple City Labs Introduces OnSight, a Molecular Assay for In-house Testing of Hop Latent Viroid

Posted: January 29, 2023 at 1:02 am

OAKLAND, Calif., Jan. 27, 2023 (GLOBE NEWSWIRE) -- Purple City Labs, a plant molecular biology company developing germplasm and technologies for the management of breeding programs and nurseries, is rolling out a Reverse Transcription- Loop Mediated Isothermal Amplification (RT-LAMP) based assay for testing and surveillance of Hop Latent Viroid.

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Human – Simple English Wikipedia, the free encyclopedia

Posted: January 29, 2023 at 12:31 am

A human is a member of the species Homo sapiens, which means 'wise man' in Latin.[3] Carolus Linnaeus put humans in the mammalian order of primates.[1] Humans are a species of hominid, and chimpanzees, bonobos, gorillas and orangutans are their closest living relatives.

Humans are mammals. They are also social animals. They usually live in groups. They help and protect each other. They care for their children. Humans are bipedal, which means they walk on two legs.

Humans have a complex brain, which is much larger than that of the other living apes. They use language, make ideas, and feel emotions. This brain, and the fact that arms are not needed for walking, lets humans use tools. Humans use tools far more than any other species.

Humans first came from Africa. There are humans living on every continent.[4][5] As of 2022, there were over 7900 million people living on Earth.[6] Overpopulation is a problem.

Humans have a long period of development after birth. Their life depends less on instinct than other animals, and more on learning. Humans are also born with their brains not so well developed as those of other mammals. This makes for an unusually long childhood, and so makes family life important. If their brains were better developed at birth, their head would be larger, and this would make birth more difficult. In birth, the baby's head has to get through the 'birth canal', the passageway through the mother's pelvis.

Many animals use signs and sounds to communicate with each other. But humans have language. It lets them express ideas by using words. Humans are capable of making abstract ideas and communicating them to others. Human language can express things which are not present, or talk about events that are not happening at that time.[7] The things might be elsewhere, and the events may also have occurred at another place or time.[8]

No known animals have a system of communication that is as elaborate as human language. By using words to communicate with each other, humans make complex communities with laws, traditions and customs. Humans like to understand the world around them. They try to explain things through myth, science and philosophy. Wanting to understand things has helped humans make important discoveries.

Humans are the only species living today known to build fires, to cook their food and wear clothes. Humans use more technology than any other animal on Earth ever has. Humans like things that are beautiful and like to make art, literature and music. Humans use education and teaching to pass on skills, ideas and customs to the next generations.

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Humans are part of the animal kingdom. They are mammals, which means that they give birth to their young, and females feed their babies with breast milk. Humans belong to the order of primates. Apes like gorillas, orangutans, chimps, and gibbons are also primates.

The closest living relatives of humans are the two chimpanzee species: the common chimpanzee and the bonobo. Scientists have examined the genes of humans and chimpanzees, and compared their DNA. The studies showed that 95% to 99% of the DNA of humans and chimpanzees is the same.[9][10][11][12][13]

Biologists explain the similarity between humans and other hominoids by their descent from a common ancestor. In 2001, a hominid skull was discovered in Chad. The skull is about 7 million years old, and has been classified as Sahelanthropus tchadensis. This skull may show that the date at which humans started to evolve (develop differently) from other primates is 2 million years earlier than scientists had previously thought.[14]

Humans are part of a subfamily called the Homininae (or hominins), inside the hominids or great apes.

Long ago, there used to be other types of hominins on Earth. They were like modern humans, but not the same. Homo sapiens are the only type of hominins who are alive today.[15] The earliest known fossils of genus Homo have been called Homo habilis (handy man). The first fossils of Homo habilis were found in Tanzania. Homo hablilis is thought to have lived about 2.2 to 1.7 million years ago.[16] Another human species thought to be an ancestor of the modern human is Homo erectus.[17] There are other extinct species of Homo known today. Many of them were likely our 'cousins', as they developed differently than our ancestors.[18] Different species of plants and animals moved from Africa to the Middle East, and then elsewhere. Early humans may have moved from Africa to other parts of the world in the same way.

The first truly modern humans seem to have appeared between 300,000,[19] and 200,000 years ago in East Africa.[20][21][22] In paleontology, 200,000 years is a "short" time. So, scientists speak of a "recent single origin" of humans. Some of these early humans later moved out from Africa. By about 90,000 years ago they had moved into Eurasia. This was the area where Neanderthals, Homo neanderthalensis, had been living for a long time (at least 350,000 years).

By about 42 to 44,000 years ago Homo sapiens had reached western Europe, including Britain.[23] In Europe and western Asia, Homo sapiens replaced the neanderthals by about 35,000 years ago. The details of this event are not known.

At roughly the same time Homo sapiens arrived in Australia. Their arrival in the Americas was much later, about 15,000 years ago.[24] All these earlier groups of modern man were hunter-gatherers.

Early human history is commonly divided into three ages. The time periods are labeled with the material used for tools.

The "Stone Age" is commonly subdivided into the Paleolithic, Mesolithic, and Neolithic periods.

Up to about 10 thousand years ago most humans were hunter-gatherers. They did not live in one place, but moved around as the seasons changed. The start of planting crops for food, called farming made the Neolithic revolution. Some people chose to live in settlements. This also led to the invention of metal tools and the training of animals. About 6000 years ago the first proper civilizations began in places like Egypt, India, and Syria. The people formed governments and armies for protection. They competed for area to live and resources and sometimes they fought with each other. About 4000 years ago some states took over or conquered other states and made empires. Examples include ancient Greece and the Roman Empire.

Some modern day religions also began at this time such as Judaism and Hinduism. From the Middle Ages and beyond humanity saw an explosion of new technology and inventions. The printing press, the car, the train, and electricity are all examples of this kind of invention. As a result of the developments in technology, modern humans live in a world where everyone is connected, for example by telephone or by internet. People now control and change the environment around them in many different ways.

In early times, humans usually settled near to water and other natural resources. In modern times if people need things they can transport them from somewhere else. So basing a settlement close to resources is no longer as important as it once was. Since 1800, the number of humans, or population, has increased by six billion.[25] Most humans (61%) live in Asia. The rest live in the Americas (14%), Africa (14%), Europe (11%), and Oceania (0.5%).

Most people live in towns and cities. This number is expected to get higher. In 2005 the United Nations said that by the end of that year, over half the world would be living in cities. This is an important change in human settlement patterns: a century earlier in 1900 only 14% of people lived in cities, in 2000 47% of the world's population lived in cities. In developed countries, like the United States, 80% of the population live in cities.[26]

Humans have a large effect on the world. Humans are at the top of the food chain and are generally not eaten by any animals. Humans have been described as super predators because of this.[27] Because of industry and other reasons humans are said to be a big cause of global climate change.[28]

Human body measurements differ. The worldwide average height for an adult human male is about 172cm (5ft 7+12in), and the worldwide average height for adult human females is about 158cm (5ft 2in). The average weight of an adult human is 5464kg (119141lb) for females and 7083kg (154183lb) for males.[29][30] Body weight and body type is influenced by genetics and environment. It varies greatly among individuals.

Human hair grows on the underarms, the genitals, legs, arms, and on the top of the head in adults of both genders. Hair will usually grow on the face of most adult males, and on the chest and back of many adult males. In human children of both genders, long hair grows only on the top of the head. Although it might look like humans have fewer hairs than most primates, they actually do not. The average human has more hair follicles, where hair grows from, than most chimpanzees have.[31] Human hair can be black, brown, red or blond.[32] When humans get older hair can turn grey or white.

Human skin colors vary greatly. They can be a very pale pink all the way to dark brown. There is a reason why people in tropical areas have dark skins. The dark pigment (melanin) in the skin protects them against ultraviolet rays in sunlight. The damage caused by UV rays can and does cause skin cancer in some people. Therefore, in more sunny areas, natural selection favors darker skin color.[33][34] Sun tanning has nothing to do with this issue, because it is just a temporary process which is not inherited. In colder climates the advantage of light-coloured skin is two-fold. It radiates less heat, and it absorbs more sunlight. In weaker sunlight a darker body produces less vitamin D than a lighter body. The selection for lighter skin is driven by these two reasons. Therefore, in less sunny areas, natural selection favours lighter skin colour.[35][36][37]

Humans are not as strong as other primates of the same size. An average female orangutan is at least three times as strong as an average human.[38]

The average human male needs 7 to 8 hours sleep a day. People who sleep less than this are generally not as healthy. A child needs more sleep, 9 to 10 hours on average.

The human life cycle is similar in some ways to most other mammals. However, there are some differences. The young grow inside the female mother for nine months. After this time the baby is pushed out of the woman's vagina, with its brain only half developed.

Unlike most other mammals, human childbirth is somewhat dangerous. Babies' heads are large, and the mothers pelvis bones are not very wide. Since people walk on two legs, their hips are fairly narrow. This means that birth can be difficult. Rarely, mother or baby may die in childbirth.[39] The number of mothers dying in childbirth is less in the 21st century. This is because of better medication and treatment. In many poor countries the number of mothers dying is higher. Sometimes it is up to 10 times as many as richer countries.[40]

In the human female, her fertile period in the oestrous cycle is hidden, and mating can take place at any time. That is quite unusual. In mammals generally the fertile period is very noticeable. Mating only takes place when the female signals her fertility. Think about cats, for example. The human cycle is unusual, and it is thought that there is a reason. Humans band together in tribes which have many people. It helps the tribe if the father of a child is not known for certainty. Men live together and work together in much larger groups than do chimpanzees (our nearest living relatives). They have a collective interest in the tribe. It is thought that the human mating system helps this.[41][42]

The average human baby weighs 34 kg at birth and is 5060 cm tall. Babies are often smaller in poorer countries,[43] and may die early because of this.[44]

Humans have four stages in their lives: childhood, adolescence, adulthood and old age.

Life expectancy is how long you are expected to live. This depends on many things including where you live. The highest life expectancy is for people from Monaco, 89.52 years. The lowest is for people from Chad where life expectancy is only 49.81 years.[45]

Psychology is the study of how the human mind works. The human brain is the main controller of what a person does. Everything from moving and breathing to thinking is done by the brain. The human neocortex is huge compared with other mammals, and gives us our thinking ability, and the ability to speak and understand language.

Neurology is the study of how the brain works, psychology is the study of how and why people think and feel. Many aspects of life are also influenced by the hormone system, including growth and sexual development. The hormonal system (especially the pituitary gland) is partly controlled by the brain.

Human behaviour is hard to understand, so sometimes psychologists study animals because they may be simpler and easier to know. Psychology overlaps with many other sciences including medicine, biology, computer science and linguistics.

Language at its most basic is talking, reading and writing. The study of language is called linguistics. Humans have the most complicated languages on Earth. Although almost all animals communicate, human language is unique. Its use of syntax, and its huge learnt vocabulary are its main features.[8][46] There are over 7,300 languages spoken around the world. The world's most spoken first language is Mandarin Chinese, and the most spoken language is English.[47] This includes speakers of English as a second language.

Art has existed almost as long as humans. People have been doing some types of art for thousands of years as the picture on the right shows. Art represents how someone feels in the form of a painting, a sculpture or a photograph.

Music has also been around for thousands of years. Music can be made with only your voice but most of the time people use instruments. Music can be made using simple instruments only such as simple drums all the way up to electric guitars, keyboards and violins. Music can be loud, fast, quiet, slow or many different styles. Music represents how the people who are playing the music feel.

Literature is anything made or written using language. This includes books, poetry, legends, myths and fairy tales. Literature is important as without it many of the things we use today, such as Wikipedia, would not exist.

Humans often categorize themselves by race or ethnicity. Modern biologists know that human gene sequences are very similar compared to many other animals.[48][49][50] This is because of the "recent single origin" of modern humans.[22] That is one reason why there is only one human race.[51][52]:360

Ethnic groups are often linked by linguistic, cultural, ancestral, and national or regional ties. Race and ethnicity can lead to different social treatment called racism.

Religion is a belief of faith in a higher being, spirit, or any system of ideas that a group of people believe in. To have faith in a belief is to have the belief without proof that it is true. Faith can bring people together because they all believe in the same thing. Some of the things religions talk about are what happens after death, why humans exist, how humans came to exist (creation), and what is good to do and not to do (morality). Some people are very religious. Many people believe in one all-powerful god; some people believe in more than one god; some people are atheists, who do not believe in a god; and some people are agnostics, who are not sure if there is a god.

Technology are the things and methods which humans use to make tasks easier. Science is understanding how the universe and the things in it work. Technology used to be quite simple. It was passed on by people telling others, until writing was invented. This allowed technology to develop much quicker. Now people understand more and more about the world and the universe. The use of the telescope by Galileo, Einstein's theory of relativity, lasers, and computing are all scientific discoveries. Technology is of great importance to science, to medicine, and to everyday life.

A war is a lethal fight between large groups of people, usually countries or states. A war involves the use of lethal weapons as both sides try to kill the other. It is estimated that during the 20th century, between 167 and 188 million humans died because of war.[53] The people who fight for a state in wars are called soldiers. The people who fight in wars, but not for a state, are usually called "fighters".

Modern wars are very different from wars a thousand or even a hundred years ago. Modern war involves sabotage, terrorism, propaganda, and guerrilla warfare. In modern-day wars, civilians (people who are not soldiers) are often targets. An example of this is the nuclear bomb dropped on Hiroshima and Nagasaki at the end of World War II. The bombs killed as many as 140,000 people in Hiroshima and 80,000 in Nagasaki by the end of 1945,[54] about half on the days of the bombings. Since then, thousands more have died from wounds or illness because of exposure to radiation released by the bombs.[55] In both cities, the overwhelming majority of the dead were civilians. In Germany, Austria, and Great Britain, conventional bombs were used. About 60,595 British,[56] and 550,000 German,[57] civilians were killed by planes bombing cities.

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Should You Be Impressed By Puma Biotechnology, Inc.’s (NASDAQ:PBYI) ROE? – Simply Wall St

Posted: January 21, 2023 at 1:02 am

Should You Be Impressed By Puma Biotechnology, Inc.'s (NASDAQ:PBYI) ROE?  Simply Wall St

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Where Does Palisade Bio Inc (PALI) Stock Fall in the Biotechnology Field After It Is Lower By -11.27% This Week? – InvestorsObserver

Posted: January 21, 2023 at 1:02 am

Where Does Palisade Bio Inc (PALI) Stock Fall in the Biotechnology Field After It Is Lower By -11.27% This Week?  InvestorsObserver

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Is Autolus Therapeutics PLC (AUTL) Stock at the Top of the Biotechnology Industry? – InvestorsObserver

Posted: January 21, 2023 at 1:02 am

Is Autolus Therapeutics PLC (AUTL) Stock at the Top of the Biotechnology Industry?  InvestorsObserver

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Where Does Edesa Biotech Inc (EDSA) Stock Fall in the Biotechnology Field After It Has Fallen -39.16% This Week? – InvestorsObserver

Posted: January 21, 2023 at 1:02 am

Where Does Edesa Biotech Inc (EDSA) Stock Fall in the Biotechnology Field After It Has Fallen -39.16% This Week?  InvestorsObserver

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Exercise promotes a molecular profile in muscle: Research

Posted: January 21, 2023 at 12:55 am

A recent paper published in the Journal of Physiology deepened the case for the youthfulness-promoting effects of exercise on ageing organisms, building on previous work done with lab mice nearing the end of their natural lifespan that had access to a weighted exercise wheel.

The densely detailed paper, "A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle," lists a whopping 16 co-authors, six of whom are affiliated with the University of Arkansas. The corresponding author is Kevin Murach, an assistant professor in the University's Department of Health, Human Performance and Recreation, and the first author is Ronald G. Jones III, a Ph.D. student in Murach's Molecular Muscle Mass Regulation Laboratory.

ALSO READ: From skipping meals to crash diets: Debunking the top weight loss myths

For this paper, the researchers compared aging mice that had access to a weighted exercise wheel with mice that had undergone epigenetic reprogramming via the expression of Yamanaka factors.

The Yamanaka factors are four protein transcription factors (identified as Oct3/4, Sox2, Klf4 and c-Myc, often abbreviated to OKSM) that can revert highly specified cells (such as a skin cell) back to a stem cell, which is a younger and more adaptable state. The Nobel Prize in Physiology or Medicine was awarded to Dr. Shinya Yamanaka for this discovery in 2012. In the correct dosages, inducing the Yamanaka factors throughout the body in rodents can ameliorate the hallmarks of aging by mimicking the adaptability that is common to more youthful cells.

that have been reprogrammed through exercise -- "reprogramming" in the latter case reflecting how an environmental stimulus can alter the accessibility and expression of genes.

The researchers compared the skeletal muscle of mice who had been allowed to exercise late in life to the skeletal muscle of mice that overexpressed OKSM in their muscles, as well as to genetically modified mice limited to the overexpression of just Myc in their muscles.

Ultimately, the team determined that exercise promotes a molecular profile consistent with epigenetic partial programming. That is to say: exercise can mimic aspects of the molecular profile of muscles that have been exposed to Yamanaka factors (thus displaying molecular characteristics of more youthful cells). This beneficial effect of exercise may in part be attributed to the specific actions of Myc in muscle.

While it would be easy to hypothesize that someday we might be able to manipulate Myc in muscle to achieve the effects of exercise, thus sparing us the actual hard work, Murach cautions that would be the wrong conclusion to draw.

First, Myc would never be able to replicate all the downstream effects exercise has throughout the body. It is also the cause of tumors and cancers, so there are inherent dangers to manipulating its expression. Instead, Murach thinks manipulating Myc might best be employed as an experimental strategy to understand how to restore exercise adaptation to old muscles showing declining responsiveness. Possibly it could also be a means of supercharging the exercise response of astronauts in zero gravity or people confined to bed rest who only have a limited capacity for exercise. Myc has many effects, both good and bad, so defining the beneficial ones could lead to a safe therapeutic that could be effective for humans down the road.

Murach sees their research as further validation of exercise as a polypill. "Exercise is the most powerful drug we have," he says, and should be considered a health-enhancing -- and potentially life-extending -- treatment along with medications and a healthy diet.

Murach and Jones' co-authors at the U of A included exercise science professor Nicholas Greene, as well as contributing researchers Francielly Morena Da Silva, Seongkyun Lim and Sabin Khadgi.

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Thanks to collaboration between Stand Up Therapeutics and VectorBuilder, a paraplegic patient will get gene therapy for the first time – Business…

Posted: January 21, 2023 at 12:47 am

Thanks to collaboration between Stand Up Therapeutics and VectorBuilder, a paraplegic patient will get gene therapy for the first time  Business Standard

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Indian Pharma Congress: Gene-cell therapy, preventive medicine future of health care, says expert – Economic Times

Posted: January 21, 2023 at 12:24 am

Indian Pharma Congress: Gene-cell therapy, preventive medicine future of health care, says expert  Economic Times

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