Should Biotechnology Stock Design Therapeutics Inc (DSGN) Be in Your Portfolio Thursday? InvestorsObserver
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Should Biotechnology Stock Design Therapeutics Inc (DSGN) Be in Your Portfolio Thursday? - InvestorsObserver
Posted: December 10, 2022 at 12:12 am
Should Biotechnology Stock Design Therapeutics Inc (DSGN) Be in Your Portfolio Thursday? InvestorsObserver
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Should Biotechnology Stock Design Therapeutics Inc (DSGN) Be in Your Portfolio Thursday? - InvestorsObserver
Posted: December 10, 2022 at 12:12 am
Where Does Ardelyx Inc (ARDX) Stock Fall in the Biotechnology Field After It Is Up 4.65% This Week? InvestorsObserver
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Where Does Ardelyx Inc (ARDX) Stock Fall in the Biotechnology Field After It Is Up 4.65% This Week? - InvestorsObserver
Posted: December 10, 2022 at 12:12 am
Vaccination helped India's healthcare system's transition from reactive to proactive: biotechnology Secretary Devdiscourse
Posted: December 2, 2022 at 12:55 am
Diabetes: Are jaggery and honey healthier alternatives to sugar? Experts help you understand Times of India
Posted: December 2, 2022 at 12:51 am
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Testosterone Replacement Therapy (TRT) Experts | Optimale
Posted: December 2, 2022 at 12:50 am
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The genes in your bodys cells play a key role in your health. Indeed, a defective gene or genes can make you sick.
Recognizing this, scientists have worked for decades on ways to modify genes or replace faulty genes with healthy ones to treat, cure, or prevent a disease or medical condition.
This research is paying off, as advancements in science and technology today are changing the way we define disease, develop drugs, and prescribe treatments.
The U.S. Food and Drug Administration has approved multiple gene therapy products for cancer and rare disease indications.
Genes and cells are intimately related. Within the cells of our bodies, there are thousands of genes that provide the information to produce specific proteins that help make up the cells. Cells are the basic building blocks of all living things; the human body is composed of trillions of them.
The genes provide the information that makes different cells do different things. Groups of many cells make up the tissues and organs of the body, including muscles, bones, and blood. The tissues and organs in turn support all our bodys functions.
Sometimes the whole or part of a gene is defective or missing from birth. This is typically referred to as a genetically inherited mutation.
In addition, healthy genes can change (mutate) over the course of our lives. These acquired mutations can be caused by environmental exposures. The good news is that most of these genetic changes (mutations) do not cause disease. But some inherited and acquired mutations can cause developmental disorders, neurological diseases, and cancer.
Depending on what is wrong, scientists can do one of several things in gene therapy:
To insert new genes directly into cells, scientists use a vehicle called a vector. Vectors are genetically engineered to deliver the necessary genes for treating the disease.
Vectors need to be able to efficiently deliver genetic material into cells, and there are different kinds of vectors. Viruses are currently the most commonly used vectors in gene therapies because they have a natural ability to deliver genetic material into cells. Before a virus can be used to carry therapeutic genes into human cells, it is modified to remove its ability to cause infectious disease.
Gene therapy can be used to modify cells inside or outside the body.When a gene therapy is used to modify cells inside the body, a doctor will inject the vector carrying the gene directly into the patient.
When gene therapy is used to modify cells outside the body, doctors take blood, bone marrow, or another tissue, and separate out specific cell types in the lab. The vector containing the desired gene is introduced into these cells. The cells are later injected into the patient, where the new gene is used to produce the desired effect.
Before a gene therapy can be marketed for use in humans, the product must be tested in clinical studies for safety and effectiveness so FDA scientists can consider whether the risks of the therapy are acceptable considering the potential benefits.
The scientific field for gene therapy products is fast-paced and rapidly evolving ushering in a new approach to the treatment of vision loss, cancer, and other serious and rare diseases. As scientists continue to make great strides in this therapy, the FDA is committed to helping speed up development by interacting with those developing products and through prompt review of groundbreaking treatments that have the potential to save lives.
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How Gene Therapy Can Cure or Treat Diseases | FDA
Posted: December 2, 2022 at 12:48 am
I. Introduction: What are stem cells, and why are they important?
Stem cells have the remarkable potential to renew themselves. They can develop into many different cell types in the body during early life and growth. Researchers study many different types of stem cells. There are several main categories: the pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells) and nonembryonic or somatic stem cells (commonly called adult stem cells). Pluripotent stem cells have the ability to differentiate into all of the cells of the adult body. Adult stem cells are found in a tissue or organ and can differentiate to yield the specialized cell types of that tissue or organ.
Pluripotent stem cells
Early mammalian embryos at the blastocyst stage contain two types of cells cells of the inner cell mass, and cells of the trophectoderm. The trophectodermal cells contribute to the placenta. The inner cell mass will ultimately develop into the specialized cell types, tissues, and organs of the entire body of the organism. Previous work with mouse embryos led to the development of a method in 1998 to derive stem cells from the inner cell mass of preimplantation human embryos and to grow human embryonic stem cells (hESCs) in the laboratory. In 2006, researchers identified conditions that would allow some mature human adult cells to be reprogrammed into an embryonic stem cell-like state. Those reprogramed stem cells are called induced pluripotent stem cells (iPSCs).
Adult stem cells
Throughout the life of the organism, populations of adult stem cells serve as an internal repair system that generates replacements for cells that are lost through normal wear and tear, injury, or disease. Adult stem cells have been identified in many organs and tissues and are generally associated with specific anatomical locations. These stem cells may remain quiescent (non-dividing) for long periods of time until they are activated by a normal need for more cells to maintain and repair tissues.
Stem cells have unique abilities to self-renew and to recreate functional tissues.
Stem cells have the ability to self-renew.
Unlike muscle cells, blood cells, or nerve cellswhich do not normally replicate stem cells may replicate many times. When a stem cell divides, the resulting two daughter cells may be: 1) both stem cells, 2) a stem cell and a more differentiated cell, or 3) both more differentiated cells. What controls the balance between these types of divisions to maintain stem cells at an appropriate level within a given tissue is not yet well known.
Discovering the mechanism behind self-renewal may make it possible to understand how cell fate (stem vs. non-stem) is regulated during normal embryonic development and post-natally, or misregulated as during aging, or even in the development of cancer. Such information may also enable scientists to grow stem cells more efficiently in the laboratory. The specific factors and conditions that allow pluripotent stem cells to remain undifferentiated are of great interest to scientists. It has taken many years of trial and error to learn to derive and maintain pluripotent stem cells in the laboratory without the cells spontaneously differentiating into specific cell types.
Stem cells have the ability to recreate functional tissues.
Pluripotent stem cells are undifferentiated; they do not have any tissue-specific characteristics (such as morphology or gene expression pattern) that allow them to perform specialized functions. Yet they can give rise to all of the differentiated cells in the body, such as heart muscle cells, blood cells, and nerve cells. On the other hand, adult stem cells differentiate to yield the specialized cell types of the tissue or organ in which they reside, and may have defining morphological features and patterns of gene expression reflective of that tissue.
Different types of stems cells have varying degrees of potency; that is, the number of different cell types that they can form. While differentiating, the cell usually goes through several stages, becoming more specialized at each step. Scientists are beginning to understand the signals that trigger each step of the differentiation process. Signals for cell differentiation include factors secreted by other cells, physical contact with neighboring cells, and certain molecules in the microenvironment.
How are stem cells grown in the laboratory?
Growing cells in the laboratory is known as cell culture. Stem cells can proliferate in laboratory environments in a culture dish that contains a nutrient broth known as culture medium (which is optimized for growing different types of stem cells). Most stem cells attach, divide, and spread over the surface of the dish.
The culture dish becomes crowded as the cells divide, so they need to be re-plated in the process of subculturing, which is repeated periodically many times over many months. Each cycle of subculturing is referred to as a passage. The original cells can yield millions of stem cells. At any stage in the process, batches of cells can be frozen and shipped to other laboratories for further culture and experimentation.
How do you reprogram regular cells to make iPSCs?
Differentiated cells, such as skin cells, can be reprogrammed back into a pluripotent state. Reprogramming is achieved over several weeks by forced expression of genes that are known to be master regulators of pluripotency. At the end of this process, these master regulators will remodel the expression of an entire network of genes. Features of differentiated cells will be replaced by those associated with the pluripotent state, essentially reversing the developmental process.
How are stem cells stimulated to differentiate?
As long as the pluripotent stem cells are grown in culture under appropriate conditions, they can remain undifferentiated. To generate cultures of specific types of differentiated cells, scientists may change the chemical composition of the culture medium, alter the surface of the culture dish, or modify the cells by forcing the expression of specific genes. Through years of experimentation, scientists have established some basic protocols, or recipes, for the differentiation of pluripotent stem cells into some specific cell types (see Figure 1 below).
What laboratory tests are used to identify stem cells?
At various points during the process of generating stem cell lines, scientists test the cells to see whether they exhibit the fundamental properties that make them stem cells. These tests may include:
Given their unique regenerative abilities, there are many ways in which human stem cells are being used in biomedical research and therapeutics development.
Understanding the biology of disease and testing drugs
Scientists can use stem cells to learn about human biology and for the development of therapeutics. A better understanding of the genetic and molecular signals that regulate cell division, specialization, and differentiation in stem cells can yield information about how diseases arise and suggest new strategies for therapy. Scientists can use iPSCs made from a patient and differentiate those iPSCs to create organoids (small models of organs) or tissue chips for studying diseased cells and testing drugs, with personalized results.
Cell-based therapies
An important potential application is the generation of cells and tissues for cell-based therapies, also called tissue engineering. The current need for transplantable tissues and organs far outweighs the available supply. Stem cells offer the possibility of a renewable source. There is typically a very small number of adult stem cells in each tissue, and once removed from the body, their capacity to divide is limited, making generation of large quantities of adult stem cells for therapies difficult. In contrast, pluripotent stem cells are less limited by starting material and renewal potential.
To realize the promise of stem cell therapies in diseases, scientists must be able to manipulate stem cells so that they possess the necessary characteristics for successful differentiation, transplantation, and engraftment. Scientists must also develop procedures for the administration of stem cell populations, along with the induction of vascularization (supplying blood vessels), for the regeneration and repair of three-dimensional solid tissues.
To be useful for transplant purposes, stem cells must be reproducibly made to:
While stem cells offer exciting promise for future therapies, significant technical hurdles remain that will likely only be overcome through years of intensive research.
Note: Currently, the only stem cell-based products that are approved for use by the U.S. Food and Drug Administration (FDA) for use in the United States consist of blood-forming stem cells (hematopoietic progenitor cells) derived from cord blood. These products are approved for limited use in patients with disorders that affect the body system that is involved in the production of blood (called the hematopoietic system). TheseFDA-approved stem cell products are listed on the FDA website. Bone marrow also is used for these treatments but is generally not regulated by the FDA for this use. The FDA recommends that people considering stem cell treatments make sure that the treatment is either FDA-approved or being studied under an Investigational New Drug Application (IND), which is a clinical investigation plan submitted and allowed to proceed by the FDA.
NIH conducts and funds basic, translational, and clinical research with a range of different types of stem cells. NIH-supported research with human pluripotent stem cells is conducted under the terms of theNIH Guidelines for Human Stem Cell Research. NIH awards are listed in various categories of stem cell research through theNIH Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC). NIH also supports a major adult stem cell and iPSC research initiative through theRegenerative Medicine Innovation Project.
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Stem Cell Basics | STEM Cell Information - National Institutes of Health
Posted: December 2, 2022 at 12:47 am
As the world draws closer and closer to the day of Christ's return, the exponential pace of technological change will play an increasing role in the fulfillment of bible prophecy.
The development of technologies such as molecular manufacturing, artificial intelligence, and quantum computing will trigger abrupt and radical changes in the global economic, social, and geopolitical landscape.
The acceleration and magnitude in development of these powerful technologies will dwarf the Industrial Revolution in size and scale.
Foreseeing such change, the world should note the various social philosophies and political movements which emerged during the Industrial Revolution. Darwinism, Marxism, Communism, Facism, and eugenics all emerged within a few short decades.
While the Industrial Revolution was not absolutely necessary for, nor was the it the cause of, the rise in popularity for each of these movements - it did serve to amplify their influence.
So what small movements might explode in popularity during the next technological revolution?
One possible candidate is the transhumanist movement...
The definition of transhumanism varies depending on who you consult, but here's Wikipedia's take:
"Transhumanism is an international intellectual and cultural movement supporting the use of science and technology to improve human mental and physical characteristics and capacities. The movement regards aspects of the human condition, such as disability, suffering, disease, aging, and involuntary death as unnecessary and undesirable. Transhumanists look to biotechnologies and other emerging technologies for these purposes." (Wikipedia)
These are noble goals. After all, who could be against ending disabilities, suffering, disease, aging, and involuntary death?
Yet the aforementioned philosophical and political movements of the Industrial Revolution - Marxism, Facism, Communism, and eugenics - all had similar utopian goals.
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Despite their promises, the real world application of each resulted in unprecedented death and destruction.
If the Transhumanist movement takes flight, it will result in more of the same.
Why?
Because all of these movements fail to address the root cause of the current human condition - the sinful nature of man.
Instead of placing God at the center, each of these movements places "extraordinary" men at the center, whether through means of a ruling elite class, a master race, or the evolutionary development of "better" human beings.
After the evolutionary theories of Charles Darwin gained widespread traction, it seems logical that most of its adherents would draw the conclusion that the current version of humanity is not "the final product," but only an early stage in a continuing evolutionary process.
This belief lies at the heart of the transhumanist movement:
"A common feature of transhumanism and philosophical posthumanism is the future vision of a new intelligent species, into which humanity will evolve, which will supplement humanity or supersede it." (Wikipedia)
In fact, following this line of thinking, human beings have a moral imperative to take charge of their own evolutionary progress and expidite the process:
"Transhumanist philosophers argue that there not only exists a perfectionist ethical imperative for humans to strive for progress and improvement of the human condition but that it is possible and desirable for humanity to enter a transhuman phase of existence, in which humans are in control of their own evolution. In such a phase, natural evolution would be replaced with deliberate change." (Wikipedia)
If achieved, the desired result would be the attainment of a "posthuman" status, akin to nirvana:
"Transhumanist thinkers predict that human beings may eventually be able to transform themselves into beings with such greatly expanded abilities as to merit the label 'posthuman.' Transhumanism is therefore sometimes referred to as 'posthumanism' or a form of transformational activism influenced by posthumanist ideal." (Wikipedia)
Given the utopian promises, as well as the exciting prospect of participating in such revolutionary change, look for the transhumanist movement to gain in popularity as we approach the singularity and the Second Coming of Jesus Christ.
Anticipation of the singularity and the exponential pace of technological change has spawned the organization of like-minded individuals who look forward to a posthuman world and seek to hasten its arrival:
"In 1998, philosophers Nick Bostrom and David Pearce founded the World Transhumanist Association (WTA), an international non-governmental organization working toward the recognition of transhumanism as a legitimate subject of scientific inquiry and public policy. In 1999, the WTA drafted and adopted The Transhumanist Declaration." (Wikipedia)
The World Transhumanist Association (WTA) has since changed its name to Humanity+, but its focus as an organization dedicated to developing transhumanist ideas and policies remains unchanged.
At its core, the organization promotes the development of the next step in humanity's evolutionary process:
"Transhumanists view human nature as a work-in-progress, a half-baked beginning that we can learn to remold in desirable ways. Current humanity need not be the endpoint of evolution. Transhumanists hope that by responsible use of science, technology, and other rational means we shall eventually manage to become posthuman, beings with vastly greater capacities than present human beings have." Transhumanist Values (Humanity+)
So what fuels this desire to transition to "posthuman" status? Is it really idealistic, utopian goals, or is it really just an inherent desire to overcome the "biological chains" of humanity?
For most transhumanists, its probably the latter.
As Wikipedia cites:
"At the EZTV Media venue frequented by transhumanists and other futurists, Natasha Vita-More presented Breaking Away, her 1980 experimental film with the theme of humans breaking away from their biological limitations and the Earth's gravity as they head into space." (Wikipedia)
A theme "of humans breaking away from their biological limitations and the Earth's gravity as they head into space?"
That theme sounds familiar...
The bible has a lot to say about our future. Approximately 3,000 years ago, King David wrote about the hearts of men just prior to the Glorious Appearing of Jesus Christ, as men prepared to "free themselves from God's slavery":
"Why do the nations rage? Why do the people waste their time with futile plans? The kings of the earth prepare for battle; the rulers plot together against the Lord and against His Anointed One. 'Let us break their chains,' they cry. 'And free ourselves from this slavery.' But the one who rules in heaven laughs. The Lord scoffs at them." Psalm 2:1-4 (NLT)
The viewpoint of end time humanity is one of animosity toward God. Humanity will view its limitations as arbitrary obstacles erected by God. As a result, humanity will prepare for battle against the Lord in an effort to break the shackles of its perceived oppressor.
The Transhumanist Declaration asserts a desire which has much in common with the attitude of humanity in the last days:
"Humanity stands to be profoundly affected by science and technology in the future. We envision the possibility of broadening human potential by overcoming aging, cognitive shortcomings, involuntary suffering, and our confinement to planet Earth." The Transhumanist Declaration (Humanity+)
When asked by His disciples to describe the time of the end and the day of His Coming, Jesus stated:
"In fact, unless that time of calamity is shortened, not a single person will survive. But it will be shortened for the sake of God's chosen ones." Matthew 24:22 (NLT)
In this translation, the phrase "not a single person will survive" is deceptive.
Why?
Because it's the result of the translator's assumption that the phrases "no flesh will survive" and "no people will survive" are interchangable.
Assuming the possibility exists for a transhumanist future, the two phrases are not.
According to Strong's Concordance, the key Greek word in this phrase is translated "sarx," and means:
"flesh (as stripped of the skin), i.e. (strictly) the meat of an animal (as food), or (by extens.) the body (as opposed to the soul [or spirit], or as the symbol of what is external, or as the means of kindred), or (by impl.) human nature (with its frailties [phys. or mor.] and passions), or (spec.) a human being (as such)"
Taken in its original context, Jesus did not necessarily say that unless those days are shortened, "humanity will not survive."
Instead, he said unless those days are shortened, "no flesh will survive."
If the transhumanist movement suceeds in transforming the human race into a race of "posthumans" who no longer need flesh covered bones to survive, then these words of Jesus take on an entirely different meaning.
And it doesn't take an illogical leap of faith to draw this conclusion.
After all, it seems reasonable to assume that humanity will have to undergo some sort of radical transformation in order to plot a war against God Almighty. The arrogant impulse already exists. All that remains is the need for an exponential increase in human power which deludes humanity into believing it can overcome the Lord of lords.
And make no mistake about it, the Bible is clear that this is where humanity is ultimately headed - physical conflict with God:
"Then I saw the beast gathering the kings of the earth and their armies in order to fight against the one sitting on the horse and his army." Revelation 19:19 (NLT)
Do not confuse the "war" with a spiritual struggle.
According to Strong's Concordance, the key word here is translated "polemos," and means:
"warfare (lit. or fig.; a single encounter or a series) - battle, fight, war."
The word "polemos" appears at least 16 times in the New Testament, and in each case, it refers to physical conflict, not a spiritual one as Paul refers to here:
"For we are not fighting against flesh-and-blood enemies, but against evil rulers and authorities of the unseen world, against mighty powers in this dark world, and against evil spirits in the heavenly places." Ephesians 6:12 (NLT)
When Paul speaks of the spiritual struggle, he uses the word "pale." According to Strong's Concordance, "pale" means:
"wrestling"
Clearly, the Bible differentiates between our everyday spiritual struggle with the forces of darkness and literal phsyical conflict in the form of war.
Regarding the Antichrist, the gathering at Armageddon, and the Glorious Appearing of Jesus Christ, it's clearly prophesied that man will engage in physical battle with God Almighty:
"From one of the prominent horns came a small horn whose power grew very great. It extended toward the south and east and toward the glorious land of Israel. His power reached to the heavens where it attacked the heavenly armies, throwing some of the heavenly beings and stars to the ground and trampling them. He even challenged the Commander of heaven's armies by canceling the daily sacrifices offered to him and by destroying his Temple." Daniel 8:9-11 (NLT)
The power of the Antichrist will be immense enough to attack the heavenly armies, throwing angels to the ground and trampling them in the process. He will even attack the Commander of heaven's armies, Jesus Christ.
But the attack is futile. Jesus will destroy the Antichrist and all those aligned against God.
Ultimately, the transhumanist agenda is nothing new.
The transhumanist movement seeks:
Some humans will ultimately achieve these goals. Through the blood of Jesus Christ, they will witness:
1) The end of death and suffering...
"There will be no more death or sorrow or crying or pain. All these things are gone forever." Revelation 21:4 (NLT)
2) The end of starvation and disease...
"On each side of the river grew a tree of life, bearing twelve crops of fruit, with a fresh crop each month. The leaves were used for medicine to heal the nations." Revelation 22:2 (NLT)
and
3) The end of disabilities...
"And when he comes, he will open the eyes of the blind and unplug the ears of the deaf. The lame will leap like a deer, and those who cannot speak will sing for joy!" Isaiah 35:5-6 (NLT)
All of these hopes are realized in heaven. So essentially, the transhumanist agenda is one that seeks to achieve heaven on earth.
The problem with the transhumanist movement is that there's only one path to heaven. All others are false:
"I tell you the truth, anyone who sneaks over the wall of a sheepfold, rather than going through the gate, must surely be a thief and a robber! But the one who enters through the gate is the shepherd of the sheep. The gatekeeper opens the gate for him, and the sheep recognize his voice and come to him. He calls his own sheep by name and leads them out. After he has gathered his own flock, he walks ahead of them, and they follow him because they know his voice. They won't follow a stranger; they will run from him because they don't know his voice." John 10:1-5 (NLT)
Final implementation of the transhumanist agenda is a blatant attempt to "sneak over the wall of the sheepfold, rather than going through the gate." It's an agenda that will ultimately fail.
Christ is the only gate that leads into heaven. Those who try to enter by any other means are doomed to failure:
"Those who heard Jesus use this illustration didn't understand what he meant, so he explained it to them: 'I tell you the truth, I am the gate for the sheep. All who came before me were thieves and robbers. But the true sheep did not listen to them. Yes, I am the gate. Those who come in through me will be saved. They will come and go freely and will find good pastures. The thief's purpose is to steal and kill and destroy. My purpose is to give them a rich and satisfying life.'" John 10:6-10 (NLT)
To learn more about the transhumanist movement and its adherent's positions, read the Humanity+ website.
Britt Gillette is the founder of End Times Bible Prophecy and the author of Coming To Jesus and Signs Of The Second Coming. Receive his book 7 Signs of the End Times for FREE when you sign up for his monthly newsletter.
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Transhumanism - End Times Bible Prophecy
Posted: December 2, 2022 at 12:43 am
Collaboration allows Hillstream to enter the rapidly growing Immuno-oncology therapeutics market
Posted: December 2, 2022 at 12:43 am
BRIDGEWATER, N.J., Dec. 01, 2022 (GLOBE NEWSWIRE) -- RVL Pharmaceuticals plc (Nasdaq: RVLP) (“RVL” or the “Company”), a specialty pharmaceutical company, today announced that Brian Markison, Chief Executive Officer, will participate in a panel presentation and host 1x1 investor meetings at the Cantor Medical & Aesthetic Dermatology, Ophthalmology & MedTech/Diagnostic Conference in Miami, FL, as follows:
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RVL Pharmaceuticals plc to Present at the Cantor Medical & Aesthetic Dermatology, Ophthalmology & MedTech/Diagnostic Conference