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Supercut of Wilford Brimley saying "Diabeetus" contrasted against other people saying "Diabetes" – Boing Boing

Posted: October 11, 2019 at 3:44 pm

Behold the master in enunciation outclass the mediocrities that surround him.

Previously in Diabeetus: Cat resembling Wilford Brimley skilled in art of playing "death by diabeetus"

Gil Gerard, star of the fantastic Buck Rogers in the 25th Century has joined 2491 as an actor and producer. 2491 was inspired by the fantastic Buck Rogers series. Hollywood Reporter: Former Buck Rogers in the 25th Century star Gil Gerard has come aboard a sci-fi project that wants to recapture the spirit of the []

Seems a pro-poker player, Mike Postle, has achieved impossible-seeming results. Other players have put hours upon hours upon hours into analyzing his baffling play. It is like watching someone play with perfect information, they claim! While nothing definitive has been found, Stones Gambling Hall, a live poker site where the questionable Postle has spent a []

Uhh whats it like? pic.twitter.com/7G2jiwdMvO Silvia Killingsworth (@silviakillings) September 25, 2019 Shaking the champagne bottle.

No matter what kind of office you work at, theres probably an Excel expert in it. And no wonder: Businesses are still discovering uses for one of Microsofts flagship software suites beyond just bare-bones spreadsheets. Make October the month you become invaluable at work by taking one of these boot camps in Excel and its []

Whoever said youd never need math to succeed in life clearly never sat down at a high-stakes poker table. When it comes right down to it, poker is a winnable game no matter where you play it as long as you play the odds. There are time-honored strategies for playing those odds, tested by []

Clearly theres a booming market for CBD out there, as more people discover the relief from pain and stress that it can bring. But not everyone uses it the same way, and thats why cannabidiol products from Common Ground are gaining ground with consumers not just because theyre one of the most trusted sources []

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Supercut of Wilford Brimley saying "Diabeetus" contrasted against other people saying "Diabetes" - Boing Boing

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Moore resident says diabetes, nutrition program improved quality of life – Sandhill Sentinel

Posted: October 11, 2019 at 3:44 pm

For more than 20 years, Cynthia Brewer had been able to manage her diabetes largely on her own. If her blood glucose levels became elevated, Brewer would adjust her daily diet based on what had always worked for her.

If I knew I was going out to supper and have a baked potato, I would watch what I ate all day and could manage it that way, says Brewer, who lives in northern Moore County.

But when those efforts recently stopped working, Brewer decided to completely cut out foods such as potato chips and crackers, believing that would control her glucose levels.

Even though I was watching what I ate even more carefully, and had eliminated certain things from my diet, my sugar levels were still high.

Simultaneously, Brewer realized she did not feel well many days and was becoming discouraged about suddenly being unable to control her diabetes as she always had.

That all changed recently when Brewers physician referred her to FirstHealths Diabetes and Nutrition Education Center. Working with certified diabetes educator and registered dietitian Michelle Cole, who directs the program, Brewer has adopted new strategies to manage her diabetes.

One of the fundamental changes has been her daily approach to eating, Brewer says.

Mostly, Ive learned to watch what I eat, and compensate for things Ive cut out with other foods, Brewer says. Shes also learned that she doesnt have to completely eliminate the foods she likes, something she had done before joining the program. Ive really cut down on things like breadIll cut an English muffin in half each morning and eat that with egg and a little bacon. Then for lunch or dinner, I might fix a hamburger and toast the other half of the English muffin and have it with my burger.

Cole says education is a key component of the program, especially when it comes to diet.

It is very common for our patients to make comments such as, I cant believe I can actually eat this much food or, I was told I cant eat anything white, but now I see that I can. Many people believe that once you are diagnosed with diabetes, you must then deprive yourself of foods and ingredients, or limit your intake of food in general.

Instead, Cole says she and her staff of diabetes educators and dietitians tell patients that no foods are off-limits but provide them with information on how certain foods affect the body and which ones are better for overall health.

Patients meet with one of the staff dietitians and receive an individualized meal plan, as well as tips for new recipes and making wise choices while grocery shopping.

A healthy diet is just one component of diabetes management, and Cole emphasizes the program works with patients on other areas that are critical to their health.

We help patients with an overall approach to exercise, monitoring glucose levels, taking medication, problem solving, reducing risks, and healthy coping, Cole says.

In addition to her dietary changes, Brewers diabetes management plan now includes insulin. She admits she was reluctant at first, but other diabetes medications werent an option for her.

Cole explained how insulin works in the body, and that sometimes diet and exercise alone arent enough for some patients to manage their condition.

After that discussion, Cole followed up with Brewers physician to recommend an insulin prescription. I felt very confident that Michelle had my best interests at heart, so I felt good about it.

FirstHealths program offers individualized and group sessions, depending on each patients needs.

We often hear feedback from our patients that having someone listen to them and spend time with them, whether in a one-on-one session or group, helps alleviate anxiety surrounding their health conditions, Cole says. Many patients particularly enjoy the group setting, meeting others and learning from their experiences of dealing with the same day-to-day obstacles they do.

Cole and her staff work hard to inform patients and dispel the myths that sometimes surround diabetes management.

In todays society, there is a magnitude of information available, Cole says. Sometimes its difficult to decipher between truth and misleading information, or even harmful information. Our program provides evidence-based information, which is derived from national standards of care.

For Brewer, the program has vastly improved the quality of her life.

I feel the best I have in a long time, Brewer says. She is quick to credit Cole, her staff and the program for giving her a new outlook on life with diabetes. Its not that you have to go through life saying I cant have this, I cant have that. You just have to have common sense about it.

Courtesy photo: certified diabetes educator and registered dietitian Michelle Cole (L) and patient Cynthia Brewer.

Contributed

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Multiple Perspectives on Nation’s Insulin Crisis Reported in Special Issue of Evidence-Based Diabetes Management – Business Wire

Posted: October 11, 2019 at 3:44 pm

CRANBURY, N.J.--(BUSINESS WIRE)--Theres no shortage of ideas and policy proposals to lower the cost of prescription drug prices, particularly insulin, which people with type 1 diabetes (T1D) need in order to stay alive. But while conversation and debate about insulin pricing continue to drag on without a resolution, patients suffer, sometimes with deadly consequences. In the September special issue of Evidence-Based Diabetes Management (EBDM), called Perspectives on Insulin Pricing, young adults speak about the effect the disease has had on their health and finances, the head of JDRF discusses legislative reform, the editor-in-chief describes the consequences of rationing and researchers outline improved adherence and cost savings by switching from analogue insulin to human insulin.

Articles featured in the issue include:

Young adults defer career dreams and scramble for steady health benefits. Young adults are grateful for the Affordable Care Act (ACA), which allowed them to stay on their parents health plan until age 26, but they tell of struggling under the weight of high-deductible health plans and high cost sharing, if they can obtain a position with benefits at all. Some worry about what will happen if the ACA is overturned and, with it, protections for people with preexisting conditions like diabetes.

Teenage recalcitrance over a diabetes diagnosis leads to adult complications. A college graduate describes the common circumstance of teenagers struggling to become responsible for a life-threatening illness, which in her case caused temporary vision loss and a rare gastrointestinal illness that led to unemployment.

We may not know the total cost of todays insulin crisis until tomorrow. Robert A. Gabbay, MD, PhD, FACP, the editor-in-chief of EBDM, says the consequences of rationing, such as more time in hyperglycemia or greater risk of diabetic ketoacidosis, increase the likelihood of future complications such as blindness and kidney failure. The total costs of diabetes complications borne by health systems triggered by todays high insulin prices may not be fully known for years.

Action is needed by Congress, insulin makers, health plans and the federal executive branch. Aaron Kowalski, PhD, the first chief executive officer of JDRF, who has T1D himself, discusses his support for a new bill that would ban rebates on insulin formations that sell above their 2006 prices.

Its possible to improve adherence and lower costs by switching insulin. The high cost of analogue insulin hurts patients by limiting affordability, worsening medication adherence and leading to microvascular and macrovascular complications, say CareMore Health researchers. The authors write about the experience of switching Medicare Advantage patients to a new regimen of human insulin, with less frequent injections and a delay in reaching the so-called donut hole, or coverage gap, in Medicare Part D.

Find these and other articles in EBDMs Perspectives on Insulin Pricing issue here.

AboutThe American Journal of Managed Care

The American Journal of Managed Care(AJMC) is a multimedia peer-reviewed, MEDLINE-indexed journal that keeps industry leaders on the forefront of health policy by sharing digital research relevant to industry decision-makers. Other brands in theAJMCfamily includeThe American Journal of Accountable Care,Evidence-Based Oncology andEvidence-Based Diabetes Management. These comprehensive multimedia brands bring together stakeholder views from payers, providers, policymakers and other industry leaders in managed care. AJMC is a brand of MJH Life Sciences, the largest privately held, independent, full-service medical media company in the U.S. dedicated to delivering trusted health care news across multiple channels.

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Multiple Perspectives on Nation's Insulin Crisis Reported in Special Issue of Evidence-Based Diabetes Management - Business Wire

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Sarah Ferguson Talks Botox and Facelifts: ‘I’ve Had a Lot of Help’ – Closer Weekly

Posted: October 11, 2019 at 3:41 pm

Looking good, lady!Sarah Fergusonis gearing up to celebrate her upcoming milestone birthday, and the beloved royal is doing whatever it takes to make sure she looks her best! During a recent interview with the Daily Mail, the Duchess of York opened up about experimenting with cosmetic procedures.

Ive had a lot of help to look like this at 60! Sarah, who is celebrating her upcoming 60th birthday on October 15, candidly shared with the U.K. outlet. Ive started the laser treatment, but its not finished yet. The collagen needs to rebuild. I hope it will all be done by my birthday.

The red-haired royal, who has long been known to fans as Fergie, referred to the same treatment she received ahead of her daughter Prince Eugenies royal wedding in November 2018. Fergie explained that she prefers non-invasive laser treatments, like the 6-Dimension Platinum Laser Lift by her friend Dr. Gabriela Mercik, opposed to more complicated procedures.

I dont like the frozen look, she confessed. Im so animated and I like to be myself. I dont like the thought of needles and am very glad if I look well and happy Im really happy to be open about what Ive had done.

Although Fergie admitted to previously trying botox, she ultimately decided to only undergo less invasive treatments in pursuit of a more youthful appearance. The former wife of Prince Andrewrevealed shes even been experimenting with mesotherapy since 2013 in hopes to help clear up years of sun damage.

According toHealthline, mesotherapy uses injections of vitamins, enzymes, hormones and plant extracts to rejuvenate and tighten the skin on your face. I need to repair the damage that was done on the beach when I was a child, Fergie explained. Its why I had the mesotherapy, the vitamin cocktail to hydrate and boost the skin.

Besides mesotherapy, Fergie has also had a facial thread lift, which involves temporary sutures placed under the skin to lift sagging areas and smooth away fine lines. Its like garden trellising for sweet peas. You insert the threads under the skin with a fine needle and they hold everything up, she said. They also encourage collagen production. It takes a couple of months, then the sweet peas bloom!

Although Fergie anticipated an extremely painful procedure, the royal beauty dished that it actually wasnt as bad as she thought. My skin responded well, she said. I think if you look at photos of me after I had it done, I look much better.

While Fergies hoping to have a more youthful look at her upcoming birthday bash, the duchess explained that the procedures dont stop at her face! Earlier this year, Fergie traveled from her home in London to the Bahamas for a new therapy treatment for her feet.

I think my toes were ruined by all the riding I did when I was young. They shaved the bone here, she said, pointing to her big toe, and implanted stem cells, 20 million of them taken from my midriff, into my feet to make new cartilage. It takes about six months to heal but now I can walk in heels!

We bet Fergie is going to look and feel better than ever at her upcoming birthday party!

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Brooke Nevils: 5 Fast Facts You Need to Know – Heavy.com

Posted: October 11, 2019 at 3:41 pm

GettyBrooke Nevils pictured on her Twitter profile page.

Brooke Nevils is an American television producer and former NBC News employee who alleges that Matt Lauer anally raped her in his hotel room at the 2014 Sochi Olympics.

Variety obtained a copy of Ronan Farrows new book Catch and Kill, in which Farrow interviews the 35-year-old Nevils, who describes the incident in detail. Nevils complaint was the catalyst to Lauer being fired as co-anchor of the Today show in 2017. NBC had kept her identity and the details of the allegations private until now.

Per Variety:

In Sochi, Nevils was tasked with working with former Today co-anchor Meredith Vieira, whod been brought back to the show to do Olympics coverage. In her account, one night over drinks with Vieira at the hotel bar where the NBC News team was staying, they ran into Lauer, who joined them. At the end of the night, Nevils, whod had six shots of vodka, ended up going to Lauers hotel room twice once to retrieve her press credential, which Lauer had taken as a joke, and the second time because he invited her back. Nevils, Farrow writes, had no reason to suspect Lauer would be anything but friendly based on prior experience.

Once she was back in his hotel room, Lauer who was wearing a T-shirt and boxers pushed her against the door and kissed her. He then pushed her onto the bed, flipping her over, asking if she liked anal sex, Farrow writes. She said that she declined several times.'

According to Farrows book, she allegedly was in the midst of telling him she wasnt interested again when he just did it, Farrow adds, Lauer, she said, didnt use lubricant. The encounter was excruciatingly painful. It hurt so bad. I remember thinking, Is this normal? She told me she stopped saying no, but wept silently into a pillow.

When Lauer asked if she liked it, she told him yes, according to Farrows book. She then tells Farrow that she bled for days, following the incident.

Nevils grew up in Missouri and graduated from Johns Hopkins University with a double major in political science and the Writing Seminars. She was a TV producer at NBC working at 30 Rockefeller Plaza until 2018 when she went on medical leave after leaving NBC and allegedly receiving a seven-figure payout from them, according to Varietys reporting.

Shes billed as a producer on several high-profile shows for NBC including Headliners, 90 Day Fianc: Happily Ever After?, and Royal Wedding Watch.

Lauer wrote a lengthy open letter denying any wrongdoing and saying that everything with Nevils was part of a consensual affair.

I had an extramarital affair with Brooke Nevils in 2014. It began when she came to my hotel room very late one night in Sochi, Russia. We engaged in a variety of sexual acts. We performed oral sex on each other, we had vaginal sex, and we had anal sex. Each act was mutual and completely consensual, Lauer wrote. The story Brooke tells is filled with false details intended only to create the impression this was an abusive encounter. Nothing could be further from the truth. There was absolutely nothing aggressive about that encounter. Brooke did not do or say anything to object. She certainly did not cry. She was a fully enthusiastic and willing partner. At no time did she behave in a way that made it appear she was incapable of consent. She seemed to know exactly what she wanted to do. The only concern she expressed was that someone might see her leaving my room. She embraced me at the door as she left.

Lauers full letter can be read here.

Nevils responded in a statement published by NBC News later on October 9, saying, Theres the Matt Lauer that millions of Americans watched on TV every morning for two decades, and there is the Matt Lauer who this morning attempted to bully a former colleague into silence, she said, in part. His open letter was a case study in victim blaming I am not afraid of him now, regardless of his threats, bullying, and the shaming and predatory tactics I knew he would (and now has) tried to use against me.

NBC News issued a statement saying, Matt Lauers conduct was appalling, horrific and reprehensible, as we said at the time. Thats why he was fired within 24 hours of us first learning of the complaint. Our hearts break again for our colleague.

Heres what you need to know:

GettyMatt Lauer attends The Rolling Stones celebrate the North American debut of Exhibitionism at Industria in the West Village on November 15, 2016 in New York City.

After the incident at the 2014 Sochi Olympics, Nevils told Ronan Farrow that she continued her relationship with Lauer. Sources close to Lauer emphasized that she sometimes initiated contact, Farrow writes, according to Variety. What is not in dispute is that Nevils, like several of the women Id spoken to, had further sexual encounters with the man she said assaulted her.

This is what I blame myself most for, Nevils tells Farrow in an interview It was completely transactional. It was not a relationship.

Nevils says in Farrows book that she continued her relationship with Lauer because she was intimidated by the power he held over her career. She also claims she told like a million people about her encounter with Lauer including her colleagues and superiors at NBC.

Nothing was done about the incident until 2017 when the #metoo movement led her Today show colleagues to ask about Lauer and urge her to report the incident to NBC.

After colleagues urged her to report the 2014 incident, she went to NBC Universal human resources with a lawyer, Farrows book reports. Her report caused NBC Universal to fire Lauer. In Farrows book, Nevils alleges that President of NBC News Noah Oppenheim, and Chairman of NBC News and MSNBC Andrew Lack were emphasizing that the incident hadnt been criminal or an assault. She claims that when she heard this she threw up.

She was promised anonymity by NBC Universal but the company said internally that the incident happened at the Sochi Olympics. This detail limited the number of possible complainants and her colleagues eventually figured out it was her.

Nevils work life became torture, Farrow writes. She was made to sit in the same meetings as everyone else, discussing the news, and in all of them colleagues loyal to Lauer cast doubt on the claims, and judgment on her.

Nevils says she never wanted money but NBC still paid her seven figures after she went on medical leave in 2018.

The network proposed a script she would have to read, suggesting that she had left to pursue other endeavors, that she was treated well, and that NBC News was a positive example of sexual harassment, according to Farrow.

On October 9, after Varietys article on Farrows book was posted, NBC Today show hosts Hoda Kotb and Savannah Guthrie addressed the news on the show formerly hosted by Lauer.

I feel like we owe it to our viewers to pause for a moment, Guthrie said. This is shocking and appalling. I honestly dont even know what to say about it. I want to say I know it wasnt easy for our colleague Brooke to come forward then, its not easy now and we support her and any women who have come forward with claims. And its just very painful for all of us at NBC and who are at the Today show. Its very, very, very difficult.

Kotb added, We dont know all the facts on all of this, but there are not allegations of an affair, there are allegations of a crime. I think thats shocking to all of us here who have sat with Matt for many, many years. So I think were going to just sort of continue to process this part of this horrific story and as you said, our thoughts are with Brooke. Its not easy what she did, to come forward. Its not easy at all.

NBC News chairman Andy Lack issued a statement saying, Our highest priority is to ensure we have a workplace environment where everyone feels safe and protected. We are absolutely committed to making this a reality there can be no exception.

Farrow tweeted, Nevils did an incredibly brave thing coming forward the way she did. She upended her life to ensure accountability and protect others.

Ann Curry also showed Nevils support, tweeting, Brooke Nevils is a credible young woman of good character. She came to NBC News an eager and guileless 20-something, brimming with talent.I believe she is telling the truth. And that breaks my heart.

Nevils took to Twitter on October 9 to thank those who have supported her.

I want to thank the many survivors who shared their stories with me today and offered their support. It takes courage, and I am truly grateful, Nevils wrote.

Brooke Nevils is originally from Chesterfield, Missouri, and graduated from Parkway West High School in 2003. After graduating from Johns Hopkins in 2007, Nevils moved to New York City and got a job as a page for NBC at 30 Rockefeller Plaza. She started out greeting guests and getting them to the set in time for their interviews.

In an interview with Arts & Sciences Magazine, Nevils says she had injured her leg in a water skiing accident right before starting and was forced to work injured her first week on the job.

My first week at The Today Show, I was taking Vicodin for my leg and getting up at 3:30 a.m. to get to work. She told Arts & Sciences, It was certainly the last place in the world I saw myself getting a job. But it worked out.

One of the first fires she had to put out was finding actor Robert De Niros wallet after he lost it in a New York City cab. Shortly after Robert De Niro arrived at the studio, his manager told Nevils he had left his wallet in their cab

I cant leave Bobby, De Niros manager told her. You gotta get it back for me. Nevils eventually found the cab, found the wallet and returned it to the Academy Award-winning actor.

After her tenure as a page ended, Nevils became a personal assistant to Today Show host Meredith Vieira for 10 months. Her relationship led to her becoming an assistant producer for A Leap of Faith: A Meredith Vieira Special in 2014 where she was nominated for an Emmy for Outstanding Feature Story in a News Magazine as a member of the production team.

According to IMDB, in the special Vieira interviews thoracic surgeon Paolo Macchiarini. This controversial surgeon has performed trachea transplant surgeries using patients stem cells as well as transplanting synthetic tracheas.

Macchiarini went on to have an affair with Benita Alexander-Noel, the producer of the documentary, and was later exposed in this Vanity Fair article. He proposed to Alexander-Noel and promising her a lavish wedding with celebrity guests before it was later found out that the wedding was a big hoax and he was still married to his wife of 30 years.

According to The Guardian, most of the 17 patients he gave regenerating windpipes to are now dead.

Along with her work with Vieira, Nevils was a talent assistant at the Today show, an associate producer on Rock Center With Brian Williams, and a researcher for NBC Nightly News, among other roles at the news network.

In addition to her work as a Producer at NBC, Nevils occasionally writes for Womans Day Magazine. She contributes self-help articles and how-to articles on things related to money and womens issues.

Her content varies wildly in subject matter from Could the Tragedy at UVA Happen to Anyone? to How to Pack Like a Travel Pro.

She wrote most of her content in 2010 and 2011 where she published an article every few months but her work slowed down drastically, presumably as her producer work intensified. Her last article, 8 Clever Strategies for Saving Big With Coupons was published in February 2016.

Nevils has also worked as an editorial assistant at Chicago Magazine and was an editorial board intern at the Chicago Tribune and the Baltimore Sun and an editorial intern at The Atlantic Monthly. She now lives in New York, according to her Twitter profile.

READNEXT: Robert De Niros Former Assistant Accuses Him of Sexual Harassment

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Why DNA Might Be the Data Storage Solution of the Future – Discover Magazine

Posted: October 10, 2019 at 7:52 pm

In the late 1990s, geneticists began studying extinct species DNA, analyzing hair and bone preserved in frozen tundra. At that time, most computers stored data on floppy disks that held just 1.44 megabytes of memory smaller than the average selfie. Today, those disks might as well be Ice Age artifacts, too. Not only is their storage capacity miniscule by todays standards, but recovering their data is practically impossible, due to the degradation of their materials and the special equipment required to read them.

The floppy disk encapsulates some of the greatest long-term challenges to computer science. According to Microsoft principal researcher Karin Strauss, future storage will need exponentially greater density to hold the data we produce as electronic devices become a greater part of our lives. Plus, long-term archiving will depend on preserving data in a format that will remain readable, on materials that wont degrade.

The answer to those challenges may lie in you, me and those same prehistoric beasts geneticists studied years ago. DNA can last for a long time, says Strauss, who is also a professor at the University of Washington. Plus, it can also store lots of information in very little space: All the genetic instructions for a mammoth lie in a single molecule. By Strauss calculation, a whole data center would be no larger than a couple cubes of sugar. And since its the code used by all life on Earth, well always be able to read it, she says.

The idea of storing data in DNA predates Microsoft and floppy disks, if not quite the woolly mammoth. DNA is a twisted ladder with rungs made of four different substrates that connect in pairs to hold the ladder together. The order of these substrates, known as bases, provides assembly instructions for the organism. In the late 1960s, scientists realized that DNA could carry other information if researchers could dictate the bases order and machines could read that order. Thanks to advances in genome sequencing and genetic engineering, these processes have finally become efficient in the past couple of decades.

Computers have also evolved to become more powerful. Still, nobody knew how to efficiently retrieve precise bits of information from DNA. That task is not trivial, says UW computer scientist Luis Ceze, who directs Microsofts research initiative with Strauss.

This year, in a joint effort by Microsoft and UW, Strauss, Ceze and their colleagues demonstrated how DNA could support future data centers. The team combined software that encodes and decodes data into DNA with machines that produce genetic material and prepare it to be read by the software. With that system, they managed to store and retrieve the word hello. The whole process took 21 hours, but, critically, it was totally autonomous. For DNA storage to be practical, we need to remove the human from the loop, says Strauss. Her robot is the first proof-of-concept for a whole new species of computing.

Still, some scientists question whether DNA is the best molecule for the job. The structure of natural DNA came from four billion years of Darwinian evolution, observes Steven Benner, a distinguished fellow at the Foundation for Applied Molecular Evolution. In that time, DNA has developed a lot of evolutionary baggage that can get in the way of smooth operation in computers, like physical differences in how base pairs behave. To address this, Benner has recently developed four artificial bases that work similarly to DNAs bases, but dont have those inherited differences.

Strauss readily acknowledges the baggage, and the long-term potential of Benners bases. But she points out that those billions of years of evolution have provided a good starting point. Equally important, she notes, theres a vast biotech industry developing the machinery that can help bring DNA storage from the lab to the data center. I think DNA is the best first molecule for molecular information technology, she says.

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Biotech experts gather at the White House for Summit on Americas Bioeconomy – GeekWire

Posted: October 10, 2019 at 7:52 pm

Federal officials discuss Americas bioeconomy during a White House summit. (OSTP Photo via Twitter)

More than 100 biotech researchers, industry executives and government officials met at the White House today for a summit focusing on Americas bioeconomy the range of products, services and data derived from biological processes and bioscience research.

The bioeconomy is already an integral part of the general economy, White House chief technology officer Michael Kratsios told the attendees. In 2017, revenues from engineered biological systems reached nearly $400 billion.

He cited figures from SynBioBeta suggesting that the private sector alone invested more than $3.7 billion in early-stage biological engineering and manufacturing tech companies during 2018.

But we are not only here because of what biotechnology has done we are invested in what biotechnology is going to do, Kratsios said.

For example, in 2017 the Food and Drug Administration approved the first treatment that makes use of CAR-T immunotherapy to fight leukemia. CAR-T that is, chimeric antigen receptor T-cells involves the use of genetic engineering to help a patients own immune cells kill off cancer cells more effectively. Several Seattle institutions, including the Fred Hutchinson Cancer Research Center, are leaders in the field.

Kratsios also cited the example of Project Medusa, a Pentagon-backed experiment that uses bacterial processes to harden the surface of a military-grade runway.

He noted that the White House lists bioeconomic innovation among its priorities for research and development funding, and that President Donald Trump recently signed an executive order aimed at modernizing how agricultural biotech products are regulated.

By speeding up the approval process for biotechnology, we will reduce the costs to review biotech plants by millions of dollars and bring new products to market faster, Kratsios said.

Looking ahead, Kratsios said the Trump administration would focus on building up the infrastructure for Americas bioeconomy, attracting talent and protecting genetic and biological data.

As the bioeconomy develops, we need to ensure it is rooted in American values and is always used for the benefit of the American people, he said.

Todays summit was meant to start the process: Officials from federal agencies ranging from the Defense Department to the Office of Science and Technology Policy laid out their perspectives on biotech, and representatives of biotech industries and academia talked about the opportunities as well as the challenges to U.S. bioeconomic leadership. Among the panelists was Rob Carlson, managing director at Bioeconomy Capital and an affiliate professor at the University of Washingtons Paul G. Allen School of Computer Science and Engineering.

This is an enormous opportunity, and requires investment and bold thinking, Carlson was quoted as saying.

The summit concluded with a string of small-group breakout sessions.

In its summary of the summit proceedings, the White House said it would work with federal agencies to improve cooperation and make sure the bioeconomy is recognized as a priority in key R&D budgets.

Last month, OSTP issued a request for information seeking input about ways to boost the bioeconomy. The deadline for submitting comments is Oct. 22.

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From Elon Musk to Jeff Bezos, these 30 personalities defined the 2010s – CNET

Posted: October 10, 2019 at 7:52 pm

This story is part of The 2010s: A Decade in Review, a series on the memes, people, products, movies and so much more that have influenced the 2010s.

The first decade of the 21st century introduced us to sweeping mobile and social revolutions largely driven by names like Jobs, Zuckerberg and Bezos. In the second decade that's now closing, things got a little more complicated. During those years, a new collection of faces have joined the earlier tech titans to continue moving us into the future. Here's CNET's list of the top technology innovators and all-around unavoidable personalities of the 2010s.

A person wears a Guy Fawkes mask, which today is a trademark and symbol for the online hacktivist group Anonymous. From 2012.

More a decentralized collective than a personality, Anonymous was the name claimed by the loose affiliation of hackers who brought "hacktivism" into the mainstream. During the first half of the decade, Anonymous launched attacks against targets like ISIS, the governments of the US and Tunisia, and corporations such as Sony and PayPal. The group's tactics included distributed denial-of-service attacks that overwhelm a target's website and knock it offline and compromising private databases to access and later leak confidential information, such as the personal details of members of the Ku Klux Klan.

In 2019, the group's prominence has faded somewhat -- last year it said it would debunk the QAnon conspiracy theory -- but concerns about hacking remain in the forefront, in part because one large collective of unknown activists put it there.

Julian Assange of WikiLeaks during a livestreamed press conference in 2017.

The founder of online portal WikiLeaks, Assange had a mission to reveal the secrets of the powerful. It made him an instant hero to many and a wanted man to others (in May the US government charged him with violating the Espionage Act). WikiLeaks started the decade by publishing documents obtained by whistleblower Chelsea Manning between 2010 and 2011, and it supported NSA whistleblower Edward Snowden after he sought refuge in Russia in 2013. To avoid extradition to Sweden on charges of rape -- the charges were dropped in 2017, but the case has since been reopened -- Assange took refuge in the Ecuadorian embassy in London, where he remained for seven years.

Despite its founder being stuck in the same building for much of the decade, WikiLeaks still managed to play a role in the 2016 US presidential election by publishing leaked emails that were detrimental to Hillary Clinton and the next year releasing thousands of documents showing how the CIA can hack into phones. The Assange saga is far from over, though. In 2019 he was booted from the embassy by the Ecuadorian government and arrested by London police. He remains in British custody and could be extradited to the US.

Now playing: Watch this: Step inside Julian Assange's office

3:25

GM CEO Mary Barra says the self-driving technology can help relieve driver stress.

The General Motors CEO became the first woman to lead a major carmaker when she took over in 2014 and has been consistently ranked among the world's most powerful women over the past decade by Forbes and Fortune.

Her tenure has been marked by GM's push to keep up and even eclipse Tesla's efforts to bring electric and driverless cars into the mainstream. The Chevy Volt EV actually brought a sub-$40,000 EV to market ahead of Tesla's Model 3, and GM has also invested in ride-sharing technology to help ensure it stays relevant in the future.

Under Barra, GM is also one of just two global businesses to completely do away with its gender pay gap, according to a study by Equileap.

Bezos speaking at an Amazon press event in 2018.

Even after losing a quarter of his Amazon shares in his divorce settlementin April, Bezos remains the world's richest person, worth more than $107 billion as of this month, according to Forbes. Throughout the decade, he spread his money around,buying the Washington Post in 2013 and growing his company phenomenally. Amazon is now a vast empire that's not only become the world's warehouse, but that also encompasses the Amazon Web Services cloud computing platform, game streaming platform Twitch, a fleet of freight aircraft, music streaming,branded convenience stores, the Kindle e-reader, the Whole Foods Market grocery chain and a space startup meant to give Elon Musk and SpaceX some competition. Its Prime subscription service delivers goods in hours, and serves up a huge gallery of movies, TV programs and audiobooks.

Amazon also makes plenty of products of its own, including its Alexa-powered home assistants and Ring security system, both of which have forced the company torespond to privacy concerns over its increasing expansion into homes. And the company continues to face criticism over working conditions and pay for its employees.

Now playing: Watch this: Jeff Bezos reveals plans for the moon and beyond

3:33

danah boyd

She may not be a household name, but danah boyd (who prefers to spell her name with lowercase) has become a leading thinker and researcher on the effects of technology on society and our children. In her 2014 book It's Complicated, she argued that social media provides an important space for youth to express themselves and to engage with each other and with society.

She's also a principal researcher for Microsoft and has broadened her research to focus on the relationship between social inequality and technology through her research institute Data and Society. In awarding her its 2019 Pioneer award, the Electronic Frontier Foundation called boyd a "trailblazing technology scholar."

Richard Branson at a Virgin Mobile event.

The billionaire magnate is willing to try just about anything, it seems. Branson's Virgin brand has dabbled in everything from media to hotels to health care, and in the last decade it has also made some far-out bets. In recent years, Branson has invested in Elon Musk's futuristic hyperloop transport technology and is working on Virgin Orbit, which could launch satellites using a combination of rockets and a high-altitude launcher plane. In the coming months, Virgin Galactic mayfinally begin launching tourists (including Branson himself) into orbit using a similar approach from the New Mexico desert.

By 2040, there will be 1 million more young women of color with coding skills if Kimberly Bryant meets her ambitious goal. The electrical engineer and Vanderbilt grad founded Black Girls Code in 2011 with the goal of reaching 1 million girls by midcentury. That could transform places like Silicon Valley, where only 2% of women working in tech are people of color, according to a 2018 report from the Kapor Center. Bryant's work has been widely recognized -- by the White House, the Smithsonian and others -- helping to bring in funding for the mission and increasing the chances that the next Steve Jobs is a woman of color.

Mark Cuban at CNET's Next Big Thing panel at CES 2013

During the 2010s, Cuban became much more than just one of the billionaires from the original dot-com boom of the late 1990s. He completed his crossover to become a major figure in the worlds of sports, entertainment and even politics.

Cuban's riches can be traced to successful exits from old, old-school internet properties like Broadcast.com, but he's since leveraged those early moves into a career as an NBA franchise owner, a TV personality (most notably on Shark Tank) and an investor in dozens of companies including Dropbox, Magnolia Pictures and Alyssa's Cookies. He was even floated as a potential presidential candidate in 2016 and 2020, but says he won't run without his family's permission.

Tim Cook at WWDC 2019.

It was a difficult job to take the mantle after Steve Jobs died in 2011, but Cook has maintained Apple's dominance over the past several years. Cook may not be the showman of his predecessor, but the brand is as far-reaching as ever. The iPhone still rules the mobile roost alongside Android, and under his guidance the company has launched forays into areas like the Apple Watch, content production, Apple Arcade and even finance with the Apple Card.

While it might be a stretch to call Cook a gay icon (he came out in a 2014 essay), he's certainly one of the most powerful LGBTQ people in the world, and his worldview has informed his drive to make Apple more ethical, diverse and values-driven, according to author Leander Kahney.

A pre-beard Dorsey.

Assuming the role of Twitter's CEO in 2015, Dorsey's been the face of one of the most highly trafficked and often toxic online platforms. Over the past decade, Twitter helped give rise to revolution in the Middle East, including the ouster of Egyptian President Hosni Mubarak, and also gave us the platform that @RealDonaldTrump has used more effectively than any other American politician to rally support and spin news events. Twitter has also enabled floods of hate speech, fake news and misinformation. Though the company has tried to combat them with new rules and technology, it's only subject to more criticism when the regulations are unevenly enforced.

As he tries to guide Twitter's central role in reshaping global media, Dorsey's also CEO of payments company Square, giving him an outsized influence in how information and money move around the world now and in the coming years.

Jennifer Doudna

One of the key innovations of the 2010s goes by the unwieldy name CRISPR/Cas9, and Doudna is a pioneer in its use to edit DNA. This new tool holds the potential to revolutionize biology, medicine, agriculture and other fields.

Doudna's lab at the University of California, Berkeley has also spun off a for-profit venture to commercialize CRISPR applications, and Doudna has become a leader in the ongoing ethical discussions around the future of genetic engineering.

Susan Fowler at the Women Transforming Technology conference

The #MeToo movement swept through the tech world and other industries beginning in 2017, thanks in large part to Fowler's personal blog chronicling sexual harassment and abuse within Uber, where she worked as a software engineer. The fallout resulted in a shakeup of Uber's power structure and the demotion of founder and CEO Travis Kalanick. Fowler's memoir, Whisteblower, is due out in 2020, and she has a new role writing for the New York Times opinion section.

This power couple has taken the money that Bill made producing the software suites we all love to complain about and turned it into a philanthropic empire. The $50 billion Bill and Melinda Gates Foundation has poured millions into global health and development efforts, as well as education in the US. Bill says the foundation played a major role in a drastic reduction of the child mortality rate, saving over 100 million lives. Bill has also stayed relevant through the reading lists he releases regularly, and Melinda debuted as an author herself with a book about empowering women around the world.

Elizabeth Holmes in a still from The Inventor: Out for Blood in Silicon Valley.

Like Pixelon's Michael Fenne (real name: David Kim Stanley) almost two decades earlier, Holmes serves as a cautionary tale for what can go wrong when the hype becomes unmoored from reality in tech.

In the span of a few years, Holmes took Theranos and a never-quite-ready-for-primetime blood-testing technology from a subject of interest to one of investment, investigation and now, potentially Holmes' own incarceration as she faces charges of criminal fraud.

The decade began with Jobs' introduction of the iPad in January 2010, nearly two years before he died in October 2011. Apple, whose iPhone helped change the way we live, has continued to be one of the most iconic and valuable brands in the history of capitalism. His legacy has been a topic of near constant discussion since his passing, including treatments in multiple Hollywood movies and major books from the likes of Walter Isaacson and Jobs' daughter Lisa Nicole Brennan-Jobs.

John Legere

T-Mobile's CEO could be the most interesting person in the wireless industry. Over the past decade, he's masterfully played the role of underdog fighting against telecom giants like AT&T and Verizon. Nearly everything the exec does seems calculated to turn heads, whether it's lacing a press conference with profanity, launching barbs at the competition on social media or dressing in the company's trademark magenta. But Legere also produced results, greatly increasing T-Mobile's customer base over the years, revamping the carrier's customer service and bucking industry trends by keeping unlimited data plans. Despite it all, Legere's future going into 2020 is uncertain, with talk he might be replaced should a pending merger with rival Sprint finally go through.

Travis Kalanick exits federal court after taking the stand during the Waymo v. Uber trial over allegedly stolen driverless car trade secrets.

The Uber founder embodies the success-at-all-costs mentality that has driven many other Silicon Valley success stories. He led a ride-sharing revolution that quickly spread around the world and made Uber the prototypical startup "unicorn." But allegations of sexual harassment (brought by whistleblower and engineer Susan Fowler) and Kalanick's own abrasive leadership style would soon see him pushed out as the company's leader in June 2017, although he still retains a seat on the board.

Tesla CEO Elon Musk

Musk wants to save the planet with electric cars and solar panels, take us to Mars, connect our brains to computers and shoot us around the world in pressurized tubes at near the speed of sound with his hyperloop-creating Boring Company. Most of this visionary's big visions are still in progress, but his credibility comes from simultaneously disrupting both the automotive and commercial space industries over the past decade with the success of Tesla and SpaceX. The world tends to watch his every move, which he often gleefully shares on social media. Musk's tweets have brought him trouble, especially when they move Tesla's stock price and invite lawsuits and the ire of the SEC or appear to smear a diver trying to rescue a Thai soccer team trapped in a cave.

Microsoft CEO Satya Nadella speaks at a company event.

This Indian immigrant with a degree in electrical engineering turned out to be the right man for the job of making Microsoft cool again. Or at least making it cooler. Since becoming CEO in 2014, Nadella has helped increase Microsoft's bottom line and make it a trillion-dollar company. He's overseen a transformation that has done away with the company's cutthroat reputation, both toward competitors and internally, though in 2014 he apologized after making controversial comments about women's pay in an interview. Nadella has also advanced forward-looking acquisitions in artificial intelligence, gaming and brand names like Github, LinkedIn and Mojang, creator of Minecraft.

Very few people seem to know who Nakamoto really is. The presumed pseudonym is attached to the person or persons responsible for the development of bitcoin, which launched a cryptocurrency revolution that started slowly in 2009 but picked up steam over the decade that followed.

A once-worthless digital currency, bitcoin has been valued at up to $20,000 per coin. It inspired the development of countless other cryptos and an entirely new industry around its underlying technology, blockchain. Although some have claimed to be the real Nakamoto and others have been falsely outed as the actual Satoshi, his true identity remains unclear.

Google CEO Sundar Pichai

Google has gone from "Don't be evil" to increasingly having to convince consumers and regulators that it isn't. When the company transformed into Alphabet in 2015 and the Google name was attached to its internet-focused subsidiary (including Android, YouTube and search), Pichai became the new face of Google as CEO. During his first four years, the Googleplex has continued to dominate everything from search to mobile operating systems to online cat videos, while making big moves with new hardware like Google Home and a fleet of Pixel devices. It hasn't been all sunshine, though. Pichai has also had to navigate the proliferation of hate speech and disinformation on YouTube, deal with walkouts over sexual harassment allegations directed at Google executives and confront criticism over a possible censored search service in China. That's to say nothing of the James Damore saga over the company's diversity policies. Still, Pichai and Google seem likely to remain on top for the foreseeable future.

Zoe Quinn.

Years before #MeToo, Gamergate gave us all a preview of the widespread bad behavior and abuse by people in positions of power that would soon be exposed across a number of industries. Quinn, along with fellow game developer Brianna Wu and culture critic Anita Sarkeesian, was among the first to be harassed and threatened by mobs of online trolls that would eventually coalesce around the #gamergate hashtag. It was an early warning sign of how bad things would become online.

Quinn, who uses they/them pronouns, turned their experience and insights into the 2017 book Crash Override: How Gamergate (Nearly) Destroyed My Life, and How We Can Win the Fight Against Online Hate. They have continued to be vocal about instances of abuse within the gaming industry while also churning out new comics (for both Marvel and DC) and collaborating on indie games.

IBM CEO Gini Rometty

CEO of IBM is another job title that doesn't seem as cool as it was 50 years ago. But since taking over in 2012, Rometty has moved the company from dinosaur status to focusing on the future. IBM today is invested deeply in nascent technologies like artificial intelligence, blockchain and quantum computing.

Sheryl Sandberg in 2015.

Sandberg was the fresh face Facebook often needed when Mark Zuckerberg spent too much time in the spotlight. While she deserves some credit for building Facebook up to the global force it is today, her 2013 business and leadership memoir Lean In made her a household name. Facebook and Sandberg have since received a healthy dose of criticism for the platform's myriad scandals, ranging from privacy concerns to the spread of misinformation, but they continue to stand their ground.

Former Instagram executive Adam Mosseri, flanked by Mike Krieger on the left and Kevin Systrom on the right.

As social media scandals increasingly give platforms like Facebook and Twitter a bad rep, Instagram seems to remain an almost-pristine place for all our best moments, no matter if they're earnest or fake AF, a la Fyre Festival. The disastrous music festival was promoted using Instagram and harnessed the power of its many "influencers" and the FOMO it engenders perhaps better than any other platform. Systrom and Krieger co-founded the photo-sharing site in 2010 and the service was snapped up by Facebook in 2012 for $1 billion. Systrom stayed on as CEO through 2018, growing the service to almost a billion registered users. While the platform has faced criticism over censorship in several countries and other practices like "shadowbanning" (in which posts are hidden from the view of others without it being apparent to the user), Instagram has remained relatively scandal-free compared to its parent company in recent years.

Peter Thiel in 2014.

Like Musk, Thiel made his first big pile of money from the sale of PayPal, which he co-founded, to eBay in 2002. The hits continued when he became Facebook's first outside investor in 2004 and went on to make early investments in Airbnb, LinkedIn, Yelp, Spotify and SpaceX, just to name a few.

Over the past decade, though, he's become better known for his political and social stances, particularly his growing disdain for Silicon Valley and his fervent support of President Trump. He also backed a lawsuit filed in 2012 over wrestler Hulk Hogan's sex tape that ultimately bankrupted gossip site Gawker, allegedly over a grudge he held against the site for a 2007 article outing him as gay. Thiel's Libertarian views have also inspired projects like the Seasteading Institute, which aims to create a society at sea, beyond the reach of any government.

Desktops are still alive and kicking, according to HP CEO Meg Whitman.

The former CEO behind the early growth of eBay is always doing something interesting. After losing a bid for governor of California in 2010, Whitman spent the first half of the decade leading and splitting up Hewlett-Packard into two businesses. After leaving HP in 2017, she turned her energies to new efforts focused on younger consumers than the typical HP customer. She's now CEO of upcoming short-form video service Quibi and an investor and board member at Los Angeles esports startup Immortals.

Mark Zuckerberg discusses Oculus at an event last month.

The decade opened with Jesse Eisenberg playing Zuck in the 2010 film The Social Network, and in recent years the Facebook founder probably would have been happy to have an actor continue to play him as CEO. As we've debated the power of Facebook and how much it knows about us, Zuckerberg has confronted multiple scandals and sat for hours of grilling by Congress over the proliferation of fake news on his platform. Through it all, Facebook has arguably been at the center of everything during the past 10 years, whether it's influencing the Brexit vote and the 2016 presidential election or the revelations that data research firm Cambridge Analytica had harvested the data of millions of Facebook users without their consent. Now presidential candidates talk of breaking up the social networking behemoth even as Zuckerberg hopes to move forward into the brave new world of VR with the help of companies like Oculus that it has swallowed over the past decade.

Originally published Oct. 10, 5 a.m. PT.

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Marvel’s ‘Powers of X’ Ends With Surprising Revelation – Hollywood Reporter

Posted: October 10, 2019 at 7:52 pm

Death was conquered, via an elaborate cloning technique, and everything looked as if things were finally turning around for Charles Xaviers friends and foes.

And then Powers of X explicitly states that things will always turn out badly for mutants.

Its much worse than that. We always lose, Moira MacTaggart tells Xavier midway through the series, and she should know; by this point in the narrative, she has lived and died nine different times, trying alternative ways to maintain the survival of the mutant race without success. (As the final issue of Powers of X reveals, Moira has lived for a thousand years in one timeline and it still ended with the mutantkind being outstripped by a humanity augmented by its own invention.

Mutants are an evolutionary response to an environment. You are naturally occurring. The next step in human evolution, a character from 1,000 years in the future explains in the issue. But what happens when humanity stops being beholden to its environment? When man controls the building blocks of biology and technology Evolution is no match for genetic engineering. What good was one mutant adapting to its environment when we could make ten super men?

Turning the franchises long-running theme on its head, the core conflict of the X-Men property isnt homo superior (mutant) versus homo sapien (man), but homo superior versus homo novissima (post-human, or genetically engineered human) a battle that, its suggested, mutantkind will lose no matter what.

Armed with this knowledge, Moira has manipulated events throughout the franchise and certain people to try and equip mutantkind as best she can in the upcoming conflict, leading to a united Xavier and Magneto announcing that she has honed them into perfect tools for an imperfect age that would change things moving forward.

The new era of X-Men comics, therefore, is one in which the majority of characters believe that theyre living in a golden age of mutantkind, but theyre actually part of the latest in a series of conflicts for survival that they are, perhaps, destined to lose. How this thread will continue through the multiple Dawn of X spinoff titles remains to be seen, but with Powers of X author Jonathan Hickman writing the ongoing X-Men series launching in the wake of this reveal, one thing is for certain: This isnt an idea that is going to go away anytime soon.

Powers of X No. 6 is available now in comic book stores and digitally.

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Poseida Therapeutics Appoints Kerry Ingalls as Chief Operating Officer – PRNewswire

Posted: October 10, 2019 at 7:52 pm

SAN DIEGO, Oct. 10, 2019 /PRNewswire/ -- Poseida Therapeutics, Inc., a clinical-stage biopharmaceutical company leveraging proprietary non-viral gene engineering technologies to create life-saving therapeutics, today announced Kerry Ingalls has joined the company as Chief Operating Officer. In this role, Ingalls will work closely with Eric Ostertag, M.D., Ph.D., Chief Executive Officer of Poseida, managing global manufacturing and operations for the Company.

"Kerry brings strong leadership in building teams that consistently deliver best-in-class results, making him a powerful addition to the Poseida senior leadership team," said Ostertag. "We welcome his robust operational expertise and experience that will meaningfully contribute to Poseida's innovative cell and gene editing technologies and plans for the future of our company."

Ingalls brings a long history of operating experience in pharmaceuticals and biotechnology. Most recently he was charged with oversight of clinical and commercial manufacturing at Amgen's headquarters location in Thousand Oaks, California. Previously, Ingalls was responsible for Amgen's largest manufacturing site, which employed 3,000 personnel in Juncos, Puerto Rico. He successfully led monumental crisis recovery efforts at this facility after being impacted by Hurricane Maria, restoring full site operations within five weeks, which provided valuable lessons to other pharmaceutical companies. Ingalls has provided oversight and leadership at multiple Amgen sites globally including US, Ireland and Puerto Rico.

In addition, Ingalls has extensive professional background and training in the United States Navy spanning 30 years, including advising senior defense leaders on critical national security issues and leading elite deployed submarine operations. He received a Master of Arts in International Law and Diplomacy from Tufts University as well as a Bachelor of Science in Mechanical Engineering from the United States Naval Academy.

"The work being done at Poseida is truly remarkable and life-changing as the company redefines the next wave of innovation in cancer and other diseases," said Ingalls. "I am incredibly grateful, excited and energized to help lead this company during its next chapter of growth."

About Poseida Therapeutics, Inc.Poseida Therapeutics is a clinical-stage biotechnology company translating best-in-class cell and gene therapies into lifesaving treatments for patients with high unmet medical need. The company is developing a wholly-owned pipeline of autologous and allogeneic CAR-T product candidates, and gene therapies for orphan genetic diseases. Poseida has assembled a suite of industry-leading gene editing technologies, including the piggyBacDNA Modification System, Cas-CLOVER and TAL-CLOVER site-specific nucleases and Footprint-FreeGene Editing. For more information, visitwww.poseida.com.

SOURCE Poseida Therapeutics, Inc.

http://www.poseida.com

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