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Stemming the Tide of Alzheimer’s – UCI News

Posted: October 9, 2019 at 2:50 pm

Keith Swayne has a magic touch when it comes to fundraising.

I guess I could go to anyone and get them to write some kind of check just so I would go away, he says, laughing. However, thats not what I want to accomplish. I want to connect people to causes and needs that they can relate to and then help them find a way to help out.

Swayne is so adroit at soliciting donations, in fact, that a campus project he undertook has left people shaking their heads in amazement: His efforts led to a $20 million windfall for investigators at the UCI Institute for Memory Impairments and Neurological Disorders.

Keiths passionate commitment to supporting our research has been tireless and nothing short of transformative, says Joshua Grill, director of UCI MIND.

It all started with a $150,000 gift the Laguna Beach philanthropist made to the research facility in honor of his late wife, Judy, whom he lost to Alzheimers disease in 2014. He also issued a challenge to the community at the time that boosted the donation to $300,000.

The UCI MIND team then leveraged that seed money to secure a total of $20 million in funding from the National Institutes of Health.

Our research is blazing new trails into understanding the genetic, molecular and cellular underpinnings of disease and is poised to lead to identification of new treatment targets and candidates, Grill says. Keiths initial challenge-gift enabled an exponential impact in terms of research support.

Weian Zhao lab at Sue and Bill Gross Stem Cell center at UCI. Lab personnel: Ling Shun, Meglu Han, Michael Toledano, Aude Segaliny, Jan Zimak, Leanne Hildebrand

His late wife would have liked that, Swayne says. The fact that some good came from this terrible disease Judy would certainly want that, he says. And I wanted that too.

The couple, married 50 years, were best friends and committed partners. Judy Swayne, like her husband, was intent on making a difference in her community. Among other contributions, in 1989, she founded the Orange County Community Foundation, which became a major philanthropic institution in the region. Keith Swayne has carried on her legacy as a member of its board, stepping down in September after a stint as chairman.

In addition, Judy Swayne served on numerous nonprofit boards, acted as a role model and mentor to many throughout the philanthropic community, and was the mother of two: a daughter, Anne Keir, who lives in Hawaii, and a son, Kirk Swayne, of Orange County.

The disease was hard on my kids, Keith Swayne says. Its a tough disease.

It was also hard on Swayne himself, Grill notes: Alzheimers is an insidious disorder that robs patients of their most human characteristics language, decision making and, of course, memory.

Ultimately, it also robs patients of their independence, putting a strain on family members.

Keith was a caregiver to his beloved Judy, a costly and taxing role, Grill says. He watched her progress until she succumbed to this unrelenting disease, helpless to do anything to slow or stop its course. He decided to do what he could to prevent others from suffering her fate.

Frank M. LaFerla, dean of the UCI School of Biological Sciences, also recalls Swaynes struggles.

Alzheimers disease really impacted his family, he says. Judy was a very special woman. He wanted to make sure future generations wouldnt experience the pain his wife did.

At the time, LaFerla was director of UCI MIND and talked with Swayne about ways he could make a difference in the search for a cure. One field of research involved stem cells, which experts believe may offer great promise for new medical treatments.

My lab had started getting involved with stem cells many years ago, and about this time a new technology was created using stem cells from your skin, not embryos, LaFerla says. You could take some of a patients skin cells by biopsy and reprogram them to become pluripotent meaning they have the ability to give rise to many different types of cells found in the body, such as brain cells or more skin cells or kidney cells.

Swayne likes innovation and taking chances, LaFerla says: I told him this opportunity was high-risk but had high potential.

That was when Swayne issued his challenge to the community and set about rounding up donors. He held salons at his hillside home, inviting LaFerla and other UCI staffers to speak to local residents. They explained how pluripotent stem cell technology could be used as a tool in Alzheimers research.

I went to people who knew my wife or to people I knew who also had a vested interest in Alzheimers research because they had the disease in their own families, Swayne says.

He found many community members who were willing to contribute.

The odds are that if you live to be 85, theres a 1-in-2 chance youre going to have Alzheimers. A lot of my friends are in my age bracket, says Swayne, 79. The message was compelling.

One thing he learned was that individuals were familiar with the Alzheimers Association but not UCI MIND.

In some respects, UCI MIND is one of the best-kept secrets in Orange County, Swayne says. Many people didnt know that its one of only 30 NIH-designated Alzheimers research centers in the country.

His fundraising zeal and efforts to involve the Orange County community in the effort eventually paid off. As LaFerla says, It worked better than we could ever have dreamed.

When the time came to renew funding for the stem cell research program from the National Institute on Aging, UCI MIND won a five-year commitment to continue its research. One reason behind the NIAs decision: local philanthropic contributions.

With charitable and federal funding in place, UCI established a bank of induced pluripotent stem cells, now a valuable resource for Alzheimers researchers globally. Today, hundreds of cell samples have been provided to investigators at UCI and 10 other research universities around the world, and UCI MIND scientists and their partners have received more than $20 million in grants.

And all of that stemmed, ultimately, from the initial gift we received from Keith, LaFerla says.

Adds Swayne: We grew $150,000 to $20 million. It blows me away.

Hes not resting on his laurels, though. Swayne continues to connect more donors to UCI MIND so that research can progress.

The UCI MIND team is devoted to this cause, he says. Its reassuring to know youve got people with this talent trying to find answers to this disease.

So Swayne writes letters to business and community leaders urging their backing, chairs a panel that seeks new opportunities for philanthropic gifts, speaks on behalf of the institute at public events, and co-leads a caregiver support group for men whose spouses have Alzheimers.

Keith gives a voice to the nearly 6 million Americans with Alzheimers and the more than 15 million caregivers like him, Grill wrote earlier this year in a letter nominating Swayne for the Outstanding Philanthropist Award, which will be conferred on Nov. 14 by the Association of Fundraising Professionals of Orange County in celebration of National Philanthropy Day. UCI MIND would not be the organization it is without the leadership of Keith Swayne.

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20 Strangest Scientific Discoveries Of The Last 20 Years – TheTalko

Posted: October 9, 2019 at 2:50 pm

The scientific world has been fascinating us ever since Isaac Newton, Charles Darwin, and Albert Einstein all the way to the discovery of Higgs Boson to inventions such as rockets, allowing us to travel the outer space. The thirst for knowledge, to find out more about the world we live in, is what leads us to the world we live in today.

Today, we're taking a look at the last 20 years and the most incredible and strangest scientific discoveries that we came across that may already be a normal knowledge in our lives or will certainly become the norm in years to come.

Click the button below to start this article in quick view

In April, astronomers announced that the atmosphere of Uranus waschock-full of hydrogen sulfide a stinky gas that comes out of sewers on Earth according to data fromthe Gemini North telescope which sits on Mauna Kea in Hawaii.

The moral of the story: not only does Uranus smell incredibly bad,study co-author Patrick Irwin, a professor of planetary physics at the University of Oxford, said in a statement that, "suffocation and exposure in the negative 200 degrees Celsius [minus 328 degrees Fahrenheit] atmosphere made of mostly hydrogen, helium and methane would take its toll long before the smell."

If you think you're looking at the dunes of a desert, think again. Back in May of 2018, visitors and residents of the Russian city, Sochi, began posting pictures on Instagram of rather strange and curious orange snow on the mountains. Apparently, the orange snow had also fallenover parts of Bulgaria, Ukraine, Romania, Moldova and Greece.

Meteorologists and scientists have later explained the cause:sand and dust had been kicked up by storms in Africa, turning into a true phenomenon of transferred sand from the Sahara to Eastern Europe.

No, we're not actually talking about "our" Earth. Back in 2018, a group of scientists reported finding a planetabout 1.6 times the size of earth, 200 light-years away from Earth and that may also be able to sustain life. Although Super Earth is a very cool name, they decided to name this new-found planetK2-155d, and it is known torevolve around a super hot dwarf star. Scientists also believe it may contain liquid water on its surface. How cool is that?

Neuroscientists have discovered all the way back in 2014 how to implant false memories into the brain. Freaky, right? Although this is not the movie Eternal Sunshine Of The Spotless Mind, a duo of neuroscientists successfully manipulatedmouses brain cells, encoding the memory of receiving a shock when placed in a small metal box. Although the mouse never really received the shock, when placed in the box, it would react in fear due to the memory implanted in its brain.

All the way back in 2014, IBM helped us take a step forward into the futurewith the release of the SyNAPSE computer chip, which simulatesthe firing of synapses that is done every day by the human brain.Dharmendra Modha, chief scientist of brain-inspired computing at IBM, told The Guardianthat there is potential in that chip to"open up a spree of tremendous innovation." He wasn't wrong because as years go by, we are now more used to AI assistance in our every day lives.

This is quite a curious one. Back in 2017, a group of scientistssuccessfully created an artificial womb out of abag of fluids that was able to grow a sheep. This breakthrough eliminates the health risk of pregnancy and presents a natural environment in which premature infants can develop. It's an incredibly smart solution and one that can save the lives of both women and children alike.

This is definitely one of the most interesting ones. In the UK, caterpillars were found to fall victim to what was known as the "zombie virus", something a researcher was able to find while counting butterflies (curious, right?). Basically, the caterpillars were being infected by the baculovirus, a virus thatstops their molting and encourages them to keep eating. Later, the caterpillar's body liquefies and explodes, spreading the virus to other caterpillars. Fortunately, the virus didn't cause too much harm to the caterpillar population.

Quantum computers are basically incredible machines that can exploit the properties of quantum physics, outperforming any supercomputer that exists nowadays.IBM unveiled its commercial quantum computer, Q System One, in January 2019 and it set the tone for quantum computers designed for commercial use.The Q System One is a 20 quantum bits machine, but it isestimated that a quantum computer capable of achieving "quantum supremacy" will requireat least 50 qubits.

No, it's not Pluto, the poor thing. Researchers at CalTech found mathematical evidence suggesting there is a "Planet X", a ninth planet on our system, beyond Neptune and unseen to us and our technology. This theory explains a lot, such as a clustering oforbits for a group of cosmic bodies beyond Neptune that current mathematics cannot account for or explain. It's also predicted to be super-sized with a mass five times over that of Earth andan orbit 400 to 800 times farther from the Sun.

In 2016,Italian scientist, Dr. Sergio Canavero, surprised the science and medical world when he claimed to have been able to transplant one monkeys head onto another monkeys body. Back then, head transplants were virtually unspoken of. "The blood vessels, spine, and neuro-systems of each monkey were connected using polyethylene glycol (PEG), a chemical that preserves nerve cell membranes." Later, in 2017, he completed yet another successful surgery, now havingtransplanted a human cadavers head onto a different cadavers body. The next step for him isto be able to perform this operation on living, brain-dead human beings.

We hear a lot about 3D printing nowadays and it's one of those inventions that has come a long way since 1986. However, when would we ever be able to imagine we could actually 3D print human organs?In May of 2019, for the first time, a 3D printed lung came to life, marking the beginning of an era in organ availability for transplant patients, making it so much easier in the future to cure patients that would otherwise wait years for a matching donor.

As it turns out, hobbits were real, but they are not taken from Lord Of The Rings or some other fantasy story.Homo floresiensis, commonly called the hobbit, was a tiny hominid that stood at three feet tall as adults and was indigenous to Flores island in Indonesia. The first bones were discovered back in 2004 and categorized asa new hominin species, though its unclear which species it evolved from.

Graphene is a one-atom-thick layer of carbon atoms arranged in a hexagonal interwoven pattern, and it's the building block of graphite, which is used in pencil tips. Why is this important? Graphene is the thinnest material known to man at one-atom-thick; and it's 200 times stronger than steel! It's also an excellentconductor of heat and electricity, making this a material that is a wonder to the world and science. Currently, scientists are working on producing it on a mass scale.

It was a little over 10 years ago, back in 2004, that a team of archaeologists dug upthe tomb of Lady Xia, grandmother to the Chinese emperor Qin Shi Huang, that lived between 259 B.C. and 210 B.C. In the tomb, they found a number of objects and animal bones (these were thought to belong to the pets of Lady Xia), but the most curious discovery was that one of those skeletons found didn't match any known species. In July of the same year, researchers announced that it was the remains of a previously unidentified gibbon that went extinct since the last ice age,naming it Junzi imperialis.

We all know the genius mind that is Elon Musk, and he was actually the one to put in practice the project of building reusable & recyclable rockets that would safely land on barges in the ocean, saving the billions of dollars that it costs to replace such technology. Even in the event of a failed launch, this would save even more money and frustration for the team, taking us one step closer toaffordable space travel.

It's not as weird as you're thinking right now, honestly. The human-pig hybrid has created with one goal in mind: to one day allow us to grow our own organs inside an animal instead of relying on human donors. What happened seems easy, but it was actually quite complex. Human stem cells were implanted into a pig embryo and removed 4 weeks later for analysis. It was successful!

Back in 2018,Chinese scientist He Jiankui announced the birth of the worlds first ever gene-edited human babies and it rocked the science world.He used CRISPR to edit the genes of two twin girls still in development to make them immune to the HIV virus. Then he transformed the embryos into the mother's uterus. The twins were born healthy, but keep their identity hidden from the media. This is, without a doubt, a huge step inin the potential of human genome editing.

This is a weird one to think about, but genetic scientists have discoveredthat all humans across the globe are related, albeit 5,000-10,000 generations removed. Now if that doesn't mess you up, I don't know what will.Approximately 60,000 to 100,000 years ago, genetics took a huge toll in which our species nearly went extinct. It's still unclear what caused this, but according to evidence in our DNA, it is estimated that less than 1,000 Homo Sapiens were alive during this hard time for our species.

With years of development in data storage, you'd think it would be possible to imagine a small disccapable of withstanding 1,000-degree temperaturesthat can hold 360 terabytes. But it really isn't easy. This is called 5D Data Storage and it's a revolutionary technology it is estimatedthat these discs can store data for up to 13.8 billion years,written on tiny patterns printed on three layers within the disc.

We all know about Dolly, the first successful genetic clone of an animal. She was cloned around 23 years ago, and since then we have been able to successfully clonemice, goats, pigs, deer, horses, cats, dogs, and even gray wolves. This has helped immensely in increasing the population of endangered animals, and it is even thought thatwe could use these techniques to bring back now-extinct animals, such as the Wooly Rhino and the Mastodon.

Sources: CNN, Live Science, National Geographic, National Post, Best Life Online

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Could a robot be prime minister? Machines will soon be smart enough to run the world, says futurist – CBC.ca

Posted: October 8, 2019 at 11:45 am

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Canadians are heading to the polls in two weeks, but one futurist argues that one day we'll be casting our votes for a robot prime minister.

"At some point we're going to create a machine that's better than the human brain, and that machine is going to be better at running the planet and running the world," said Zoltan Istvan.

"You really have an opportunity here to maybe get what we can see as true leadership, for the very first time in perhaps everyone's lifetime."

Istvan ran in the 2016 U.S. presidential election under the banner of the Transhumanist Party, a group that believes in using technology to modify and enhance our intellect and bodies as long as no harm results to anyone else. He is not running in the 2020 campaign.

He said people he met along the campaign trailwere skeptical of the Transhumanist pitch, but argued that people underestimate how quickly technology is advancing.

He told The Current's Laura Lynch that "almost every single action that a human does, a machine can almost certainly do dramatically better."

"When you talk about running a country, you talk about governing for the greatest good," Istvansaid. "Amachine is going to have better algorithms."

He added that one benefit of robot leaders would be that they could improve over time, weeding out idiosyncrasies or issues experienced by previous iterations.

A robotprogrammed to lead wouldn't necessarilybe stuck behind a desk on Parliament Hill it could beartificial intelligence that you could access anywhere, like a smart speaker in your living room.

The implication for democracy would be that "in the future, an AI will be able to keep on millions and millions of close relationships with its voters base," Istvansaid.

It "might be campaigning right in your living room," he added.

"That's where this becomes really interesting, is a really direct relationship with a potential AI political leader."

Kerstin Dautenhahn, Canada 150 research chair in intelligent robotics, said she "would definitely not want political leaders to be robots."

She told Lynch that "we need to maybe be realistic on what machines are good at, and what humans are good at."

"AI is certainly very good [at] enhancing vast amounts of data, so for example, recognizing one face in a million different faces, or collecting data on people's habits and then recognizing patterns," said Dautenhahn, director of the social and intelligentrobotics research lab at the University of Waterloo.

"What machines are not very good at is common sense and general intelligence, so for example machines lack compassion, they lack empathy."

Dautenhahn said those common sense decisions are vital for politicians "because they are dealing with incomplete information, they have to make quick decisions, they have to make predictions."

"That's what people are very good at and it is because we are human beings," she said.

Istvan argued that decisions based on emotion can lead to "total chaos."

"That's why we want pure reason, pure statistical analysis," he said.

He told Lynch that "even if the picture is incomplete, a statistical analysis of that would make a much better decision than something that comes out with emotions."

"Frankly, the last thing I want is [U.S. President Donald] Trump to be emotional as he's making decisions with the military and things like that."

Istvan said the qualities needed for leadership could eventually be programmed into robots, but Dautenhahn warned that the people programming them could unwittingly introduce their own biases.

"I would certainly not vote for a robot because ... there's no such thing as pure rational decision-making," she said.

Dautenhahn acknowledged that humans make mistakes, but perhaps robotics could be used to help us make better-informed decisions, rather than just making them for us.

"I think humans are pretty, pretty, pretty, pretty good in what they're doing, and they can certainly be complemented by AI, in areas where the AI is very good."

Written by Padraig Moran. Produced by Ben Jamieson.

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Education and Enhancement in a Transhuman Future – Patheos

Posted: October 8, 2019 at 11:45 am

by David Lewin

Should we expect the schools of the future to be saturated with technology? It has been widely reported (e.g. https://www.entrepreneur.com/article/319288) that some leaders within major Silicon Valley tech companies have, rather hypocritically, chosen to limit the influence of their products on their own children, by restricting access to screen time and social media. Take the following report:

You cant put your face in a device and expect to develop a long-term attention span, [said] Taewoo Kim, chief AI engineer at the machine-learning startup One Smart Lab A practicing Buddhist, Kim is teaching his nieces and nephews, ages 4 to 11, to meditate and appreciate screen-free games and puzzles. Once a year he takes them on tech-free silent retreats at nearby Buddhist temples. (https://www.businessinsider.com/silicon-valley-parents-raising-their-kids-tech-free-red-flag-2018-2)

Other educational spaces also appear to provide shelter from technology saturation, for instance Waldorf schools, which prioritise outdoor learning and low-tech play. This concern to shelter students reflects certain perceived risks of technology saturation: distractedness and diminished attention span, heightened depression and anxiety, poor health and obesity and, in extreme cases, suicide. Limiting access to technology has become newsworthy because of the prevailing assumption that technology enhances education. Whatever the truth of the matter, we currently know little about the long-term impact of many technologies on the educational formation of young people: the influence of technology seems widespread, indeterminate, and seldom given sufficient justification. This knowledge gap is by no means unique to modern technologys educational interventions, but is at the foundation of education itself: there is an interpretive gap between what educators intend and what students learn.

This raises two general questions: First, how do we justify influencing others? If the answer to this question is basically consequentialist (because the outcomes of influence are good), then we are presented with a second question which problematizes this response: namely, what are we to make of the gap between our intentions to influence or enhance, and the outcomes of these intentions?

I would argue that human enhancements have existed as long as education itself. Nick Bostrom and Anders Sandberg (https://nickbostrom.com/cognitive.pdf) have suggested that education may be usefully labelled as a conventional means of human enhancement, as distinct from nominally unconventional means of enhancement, such as nootropic drugs, gene therapy, or neural implants. This distinction has its place, though Bostrom and Sandberg acknowledge the continuum between enhancements that are conventional (working through education) and unconventional (drawing upon recent technologies), making the distinction fluid, indeterminate and contextual. Caffeine is one thing, but gene editing for purposes of non-therapeutic interventions (e.g. selecting or removing traits in reproduction) remains controversial. Of course, convention is a rather unstable form of justification. In general, the question of the justification of unconventional enhancement parallels that of conventional enhancement. It is one of the key questions that shapes education theory: namely, how are our intentions to influence justified?

The gap between the intentions and the outcomes could be understood as a weakness or risk intrinsic to education. Gert Biesta speaks of the beautiful risk of education (https://www.youtube.com/watch?v=QMqFcVoXnTI), arguing that it is a misconception to see education as a stable relation between inputs and outputs in which we can eliminate the unexpected or the risky. To construe education without risk is to miss something of its beauty. Education can make use of, or better, relies on this gap in order to create spaces that are essentially open to something unbidden, an opening that involves, as Hannah Arendt puts it, the coming of the new and young. By contrast, the sciences of learning have worked to eliminate this gap through the development of what is known as the behavioural objectives model in which measurable educational objectives and outcomes are made explicit and become the sole target of education. The behavioural objectives model can be interpreted as the expression of technical subjectivity in which all forms of insecurity are eliminated in favor of pure transmission, and the risks of exposure to the unbidden are minimised. The idea that behavioural objectives ensure control of the educational process is seductive but, illusory and ultimately corrosive since, as Arendt, Biesta and others have argued, the educational event itself depends upon the introduction of something radically new. What makes the new radical here is that there is a discontinuity between the conditions in which newness may arrive, and the very arrival itself. Something about the new is necessarily unanticipated. Without the new, education becomes the reproduction of the old which, echoing Adornos critiques of Halbbildung (half-education), is only ever half the educational story.

This gap between educational intention and what actually takes place demands something of those involved: speculative, or interpretive judgements. We might say that interpretation constitutes the pedagogical relation between educator and student: the educator speculates that the student is educable, projecting ideas about what capacities the student could realise through certain educational influences; the student speculates about what the educator intends and is capable of, e.g. that they are (or are not) both interested in and able to support the students growth. Then there is speculation about the outcomes of the educational event: the enhancement of a capacity may not be immediately obvious to the student or educator, taking days, months or even years to be properly realised or recognised. In short, there is a great deal of faith in pedagogical structures, processes and relations. This is significant because unconventional means of enhancement likewise involve speculation, risk, and judgement. Just as writing may enhance or diminish human memory, so ubiquitous access to google may extend and undermine certain cognitive capacities; at least an ambivalence should be noted. Unconventional means of enhancement through, for instance, drugs like Ritalin or Modafinil, might be thought to involve unacceptable risks in comparison to conventional schooling, but risks are part of any effort to influence because they are defined by the gap described between intention and outcome.

In her essay The Crisis in Education, Arendt says that hope always hangs on the new which every generation brings; but precisely because we can base our hope only on this, we destroy everything if we so try to control the new that we, the old, can dictate how it will look. Indeed, the older generation cannot fully anticipate changes brought on by the young but can, indeed must, show the world and let go, hoping that in doing so conditions are created in which the new may arrive. Education involves creating conditions in which it is possible for the new to come in to the world, conditions that might also be described in terms of openness: openness to the mystery, the unbidden, the Other, or as self-transcendence.

I would not be the first to challenge the view that the technologically defined immortality of transhumanism would be an enhancement, though my challenge is based on educational insights. Specifically, the transhuman quest for immortality, in which the old seeks to sustain itself indefinitely, seems to oppose the radical renewal of education described by Arendt and others. There is the basic problem of resources: the old must make space for the new by the renewal of life through death, which perhaps could be solved by extraterrestrial colonization or through digitization and uploading. However, the educational principle that life is constituted by a creative tension between those coming in to the world (the young) and those going out (the old) is a basic condition for life itself. The necessity of education correlates with the necessity of the renewal of the world.

Rather than being regarded as revolutionary or radical, transhumanism is, then, fundamentally and ruinously conservative: it seeks to sustain what is, as it is. Transhumanists sometimes berate those who are hesitant about the scale and scope of technological change as bio-conservative, though maybe the transhuman community itself that is the most conservative of all: it fails to see how the preservation of the old world is an affront to the ongoing renewal that sustains the world.

This renewal is not a case of the new entirely replacing or displacing the old, as a cult of youth might have it. By no means does this jettison tradition and the past. In order for children to arrive in the world, they must, says Arendt, be introduced to it. Herein lies the legitimate but limited authority of educators: that, by showing the world, they are able to take responsibility for it, while letting the forces of renewal remake it. Arendt ends her Crisis in Education essay with the following appeal to love:

Education is the point at which we decide whether we love the world enough to assume responsibility for it and by the same token save it from that ruin which, except for renewal, except for the coming of the new and young, would be inevitable. And education, too, is where we decide whether we love our children enough not to expel them from our world and leave them to their own devices, nor to strike from their hands their chance of undertaking something new, something unforeseen by us, but to prepare them in advance for the task of renewing a common world.

For Arendt, this renewal is not realised in a techno-utopia in which we may exist indefinitely, but a common world in which the old order is in constant transformative renewal. This means convention and tradition provide the ground for representing the world to the young, who then are able to introduce something new through invention and transformation. This balance between old and new, past and future, makes education both necessary and possible.

My concerns are less that transhuman prospects for extended or unending life are real possibilities than what these prospects indicate about contemporary attitudes to human formation and education: namely, the current technologisation of education disregards the interpretive gap which makes education more than a mechanical process of construction. Bringing to view the interpretive gap reminds us that renewal is both possible and essential in order to exceed the conservative forces that seek only to recreate the patterns of the past.

Every parent, educator and transhumanist has an idea of the good and a belief or hope in the possibility of realising it; what might be called a faith in the future. Faith is necessary because of the gap between our intentions to make change, and the outcomes of those intentions. There is a twofold problem: we often dont know whether change is good, and even if we did know this, we often dont know if change can, or has, been realised. It is the human condition to live in this gap, a gap that requires us to live between the conventions and traditions that ground us, and the inventions and transformations that develop us. This gap ensures that, thankfully, the influences of the old on the young are not entirely mechanical or predictable, and that our humanity is staked upon a wager to affirm the world without hanging on to it indefinitely. Because of this gap, it is incumbent upon us to reflect upon the judgements that we must inevitably make, and the possible futures in which we put our faith, hope and love.

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Heavy data protection regulation looms in Labour plans for post-Brexit flows and IoT devices – The Register

Posted: October 8, 2019 at 11:45 am

A minister has said that future Internet of Things and data regulation will take into account "decisions that we need to be aware we are making" when handing personal data over to tech companies.

Junior tech policy minister Matt Warman told a Westminster Hall debate of MPs last week that the IoT "represents a whole new chapter of how technology is becoming more common in our homes".

The debate occurred on the same day as the incumbent UK Home Secretary, Priti Patel, co-signed a letter with the US attorney general and Aussie Home Affairs minister requesting that Facebook "does not proceed with its plan to implement end-to-end encryption... without including a means for lawful access to the content of communications..."

One-time Ofcom gros fromage Chi Onwurah MP secured the debate, supposedly as a discussion about IoT regulation. It veered a bit into Labour Party electioneering for a new digital society based on heavy regulation of largely American tech and data-trading companies.

"We need an architecture of standards and a regulatory framework that enables security and interoperability across the internet and also considers the lifeblood of the internet of things data," said Onwurah.

Enthusiastically promoting a heavy-touch view of future UK IoT regulation, she continued: "That libertarian idea that technology is the answer to everything has driven our regulatory approach for too long, so he [Warman] is right to say that we need experts on technology who can stand up for and consider its future applications from the point of view of society and citizens."

Her Labour colleague Jon Cruddas, MP for Barking, reinforced this by dismissing Silicon Valley's confidence "in the potential of technology [which] goes hand in hand with a widespread libertarianism," while bizarrely adding: "What happens when transhumanist thinking informs the technologists?"

Transhumanism discussed in this 2017 Reg lecture here is, as many a reader will know, famously espoused by Kevin "Captain Cyborg" Warwick and Dmitry Kaminskiy of Deep Knowledge Ventures, who once appointed a robot to his company board.

SNP MP Patrick Grady observed, rather shakily, that he wasn't sure if his political party "has an established view on transhumanism" but returned to the topic of the debate to say that the IoT "is already part of some people's daily lives, perhaps without them even realising or with them already taking it for granted."

Liam Byrne, Labour's shadow Minister of Fun*, compared the rise of the IoT to the Industrial Revolution, giving PR flacks the world over a little shiver of delight, and likened the situation now to Adam Smith's linen shirt. Comparing that economic need (a man without one in Smith's day was thought to be poor, simply because everyone else at the time had one) to the progress of tech across the world, Byrne called for a digital "bill of rights" combined with "powerful regulation" to curb "some of the biggest, wealthiest and most powerful companies on earth".

Responding to all this, Warman said: "This is a debate about data, not the internet of things The consumer has to understand that they are giving up their data for a particular purpose and a particular benefit.

"I commend the approach that says we are dealing with issues that go far beyond a debate about technology," continued Warman, "which will have an impact on huge aspects of humanity itself, whether we get them right or wrong."

He then went on to claim that there will be 75 billion IoT devices worldwide by 2025, a figure that is half again as large as the discredited 50-billion-by-2020 figure disowned by Ericsson some years ago.

Whatever the future of IoT and/or data regulation, the government will probably remain tied up in Brexit for years to come.

* Department for Digital, Culture, Media & Sport

Sponsored: How to Process, Wrangle, Analyze and Visualize your Data with Three Complementary Tools

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Heavy data protection regulation looms in Labour plans for post-Brexit flows and IoT devices - The Register

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A Doctor Plumbs The Depths Of Ivan Doig’s Illness And Asks: ‘Did He Have An Epiphany?’ – Mountain Journal

Posted: October 8, 2019 at 11:41 am

I grew up in Ohio and met my first real Westerner at age 27. Kate was from Durango, Colorado and lived next door to me for two months during a rural primary care rotation in medical school. They rolled up the sidewalks at night in Twin Falls, Idaho and so we had plenty of time to talk. Books always figured prominently in the conversation and she recommended her favorite book about the West

Reading that first iconic chapter, Time Spent, led to a 25-year Doig odyssey that eventually landed me in a Montana State University archive reading the final draft of that same chapter, marked up with Ivans own red pen.

It begins, That start of memorys gather: June 27, 1945. I have become 6 years old, my mothers life has drained out at 31 years. And in the first grey daylight, dully heading our horses around from that cabin of the past, my father and I rein away toward all that would come next.

The Doig archive at Montana State is a treasure trove for fans. Its extensively indexed and entirely on line and filled with pictures, original manuscripts and the collection of 3 x 5 and 5 x 8 cards on which Doig kept quotes and observations from his extensive research travels in Montana.

Ivan kept box after box of these cards, many of them with only a single type written sentence, sometimes annotated in longhand. He shuffled and reshuffled these bits of memory assembling them into temporary collections as material to flesh out a particular character or story line and then returned them to their boxes only to be reshuffled and reassembled for the next novel.

In summer 2019, Carol Doig met with a group of visitors and discussed her husband's journey in his last years. Joining them was her close friend, Betty Mayfield, who helped assemble Doig's edited manuscripts, diaries, correspondence and other documents that today are part of the MSU Doig collection. Those joining Carol in her living are, left to right, Betty Mayfield, Dr. Rob Patrick, Justin Shanks a post-doctoral fellow working on the Doig material to make it digitally accessible, and writer Todd Wilkinson of Mountain Journal. Photo by Kenning Arlitsch, dean of MSU Libraries

Sometimes this shuffling was frozen into a more permanent form when he collected them into 2-to-3 page novellas with titles like Scotchisms and Curses.Most assumptions arent conscious until they are shattered. Without realizing it, I had cast my favorite writer in his own movie that ran only in my head.

He woke up in the morning, hunted big game, slept with the world's most beautiful women, cavorted at the Algonquin round table, drank his weight in scotch and then, late at night, great work flowed forth from his pen in a tortured and inspired torrent. He threw himself down exhausted, only to arise and repeat the performance with the dawn. The truth that emerged from touching the physical remnants of his process was far different.

Ivan Doig was . . . a nerd . . .just like me. I clipped articles and collected them in folders, wrote down random thoughts and observations on cards, restacked, hoarded and recombined information. My stories were just about thrombocytopenia and clonal proliferation instead of resilient ranchers scraping out an existence under the Big Sky.

The champion of the lariat proletariat was a closet geek. How disappointing.But my biggest disappointment was yet to come.The archive contained an odd and alluring folder title medical journey that was irresistible to me as a physician. I hadnt realized that Ivan suffered from multiple myeloma for the last eight years of his life and had written four books after being diagnosed with a terminal disease.

Myeloma is a strange form of cancer as cancers go, it is both painstakingly slow to progress and inexorably fatal. Patients rack up complications from the treatment, not because treatment is so toxic, but because they live long enough to suffer from the cure as well as the disease.

The core of the pathology is something called a plasma cell which under normal circumstances produces the antibodies that help fight off invading viruses and bacteria. In myeloma, a single plasma cell mutates and grows uncontrollably crowding out everything else in a patients bone marrow and gumming up their organs with immunoglobulin. The mutant cells eventually cant be contained inside the bone marrow and invade the surrounding solid bone causing painful fractures in the spine and long bones of the skeleton.

As if that was not bad enough, the core of chemotherapy is high dose steroids, usually dexamethasone or prednisone. Steroids are the poster child for double edged swords in medicine. They are simultaneously incredibly useful for suppressing the immune system in autoimmune diseases, cancer and anything that involves inflammation, while at the same time having the most broad ranging side effect profile of almost any medication.

It was a love for wildlands in the West that led Rob Patrick, at right, down the trail of Ivan Doig's books and when he had an opportunity to dive deeper into Doig's final years he jumped at the chance. Another thing that brought him to Bozeman and Greater Yellowstone is his close friendship with Kenning Arlitsch, Dean of MSU Libraries. Here they are on an autumn trip into the Yellowstone backcountry.

Probably the most serious side effects for myeloma patients are immunosuppression leading to increased risk for infection, a softening of the bones accelerating the tendency of the disease to cause fractures and emotional lability. The last of these sounds trivial, but isnt.

My first patient who suffered from this particular side effect literally started a sentence laughing and ended it crying. The cognitive effects can be especially debilitating, because at its peak, the drug lulls one into a false sense of security. It can make patients feel super human and I had one multiple sclerosis patient tell me it was the most powerful antidepressant she had ever taken and she almost looked forward to her next flare so she could get it again. However, on the way up and the way down it can cause confusion and a loss of emotional control that is profoundly disturbing, especially to someone who depends on their brain to make a living. Truly a blessing and a curse of modern medicine.

One of my biggest losses of innocence after medical school was realizing that professors had pulled the wool over my eyes concerning one of the fundamental diagnostic tools in medicinethe patient history. During the pre-clinical years you seldom get to talk to an actual patient and instead hone your skills using case presentations which I later came to understand were carefully curated stories masquerading as actual patients in which the non-salient details were conveniently expunged and the salient ones amplified for teaching purposes.

My teachers smugly told me, If you dont know whats wrong by the time you finish taking the history, take the history again." This illusion is perpetuated during third year clerkships when cases are cherry picked for medical students so as not to dispel the myth. The gloves come off during internship when it is too late to turn back and you realize that most patients have a hard time telling you how they feel no matter how many creative ways you come up with to ask the same question. Its not their fault, they usually just have never felt like this before and dont have the words to describe it.

When you add intoxication, mental illness, dementia, etc. to the mix, taking a history often becomes an exercise in communication breakdown and frustration. So imagine my joy at finding a history written by a professional communicator whose livelihood depended on his ability to observe the world and record it. It was like winning the internal medicine lottery.

Doig observed of myeloma: The waiting room of hell, furnished with side effects.

Of those side effects, he observed, The dex makes me longitudinal - - concentrated on a single line of endeavor at a time, no latitude to speak of and I would go to blow my nose and find there was not a handkerchief within 50 of me. Pill bottle caps leapt for the floor. My ordinary thought process resembles a homesteader digging out a stump, when loaded with dex I plodded right past nuances of life in temporary fixations on getting to my desk and writing things down. Which, amazingly, produced pages of a novel faster than when I wasnt taking the stuff. Dex gave me a mental pop, off-the-chart energy upstairs while it played games with the rest of me. Writing proved to be therapy for therapy.

On the topic of mortality, he explained in a written passage, I am now in remission, that terra incognita but better than being off the map(oblivion). He would add, I have not come out of this as any cheerleader for Nietzche: thera are countless preferable ways to strengthen in life without having something trying to kill you.

Facing the reality, he noted, Invariably fatal. Damn. But then, so is life. Its probably not polite to laugh out loud at the writings of a dying man, but I couldnt help myself and I also couldnt help wondering what a pleasure it would have been to take care of him. There was plenty of correspondence in the archive between Ivan and his doctors, but the most striking examples would probably have been overlooked by the uninitiated. The age of electronic medical records and e-mail allow patients unprecedented access to providers.

Like most technology, this chart messaging is both a blessing and a curse. The blessing is that it doesnt take three phone calls to catch a patient at home and tell them about their lab results.

The curse is the dozens of chart messages to return at the end of a busy day. Consequently, as Doig chronicled, brevity is the rule: Everything normal on your labs today, see you in 6 months."

Doig, when in his prime, trying to instill the lessons of history into his work. Here he absorbs the vibe in an abandoned farm house where heart-felt dreams rose, fell part like a heartache and drifted away. Photo by Carol Doig, courtesy MSU Library Doig Archives

The messages from Ivans providers went on for paragraphs, like post cards from your grandmother, and often came close to open displays of affection. All patients are equal, but some are more equal than others.

My day in the Doig archive was followed by an evening at the annual trout lecture hosted by the MSU library and I happened to find the only other Doig nerd who had spent any time with the medical journey files. Todd Wilkinson, the editor of Mountain Journal, shared my fascination with this little known part of Ivan Doigs life and suggested we pursue an event centered around his medical journey.

I couldnt imagine who else would show up to hear about such a niche topic, but didnt want to spoil the glow of our mutual fandom and encouraged him to pursue it. Three months later I found myself sitting in Carol Doigs living room in Seattle.This would be a good time to disclose that I am not a casual Doig fan. Im not a religious person, but I have made two literary pilgrimages in my life. The first was to Arches National Park to find the location of Edward Abbeys trailer from Desert Solitaire and the second was to White Sulfur Springs, Montana to see the place that had figured so prominently in Doig'sThis House of Sky.

Something still haunted me about the archives. Aside from the few pithy quotes above, there wasnt much mention of how Ivan faced his own mortality. How does an author get up every day and write four more novels when he knows hes dying? More importantly, why does he do it?

My practice over the last 20 years was working as a hospitalist. All of my patients were sick enough to be in the hospital and these days you have to be pretty sick to make it through those doors. I had seen hundreds of patients die and typically had end of life conversations with patients and families several times a week. Indeed, I had been on a personal crusade in the last few years to get doctors to talk with their terminally ill patients about their goals for the end of life and had coached other providers about how to do it.

So here was my chance to salvage something of my shattered romantic ideal about writers. Ivan must have had some big epiphany, I thought, that just wasnt there in his writing and my task was to extract it from his widow. I was as if a literary anthropologist on a mission.

It led to having a wonderful day in Seattle, sunny and warm; the Doig living room had a commanding view of Puget Sound. The house was spare and elegant and warm and inviting all at the same time and I got to see Ivans personal desk with his typewriter and his book collection.

Carol was charming and intelligent and well educated and everything you would expect from the spouse of your literary hero. Todd Wilkinson was there and Kenning Arlitsch, Dean of Libraries at MSU, too, and the person responsible for securing the Doig archive. Our conversation flowed easily.

Todd had a flurry of journalistic questions for Carol about Ivan and his writing. I was the final interviewer and my experience told me that it was almost always the wife that was the keeper of the medical history. So I started with some easy logistical questions.

Doig's desk, where he completed five books in eight years, battling through pain, the effects of medicines and a bone marrow transplant. All this and yet critics say these final works contain passages that are among the most incisive and moving of his four-decade long career. Photo by Todd Wilkinson

No, she did not go to all of his medical appointments with him and she didnt even know about the folder where he had kept all of the materials about his illness until after his death. There goes my first assumption.

We walked through the chronology of his illness, his initial diagnosis, the stem cell transplant, chemotherapy, remission, relapse, second line chemotherapy. What was daily life like? How did they deal with telling friends and family since he was not obviously ill until the end? How long was he on hospice? What was it like at the end? I probed, I rephrased, I asked the same question a different way. But there was no profound epiphany.

What she described instead was a guy who got up every day, made breakfast, went to his study and pounded out his words for the day. If he finished a novel on Friday, he started the next on Monday. A literary proletarian if there ever was one.

I have watched plenty of people die in my career, some face it with grace and dignity and resolve and some fight it and raise their fist against the sky until the last breath. What separated those who faced their end well from those who didnt?

Regret. Regret for things they hadnt done or relationships that had soured, but it boiled down to not living life the way they wanted to. My epiphany was that there was no epiphany. Epiphanies are extraneous when you are already living your best life. Ivan Doig was a wonderful writer, husband, friend, and colleague. If it isnt broken, dont fix it.

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Regenerative medicine today: Are diabetes and vascular disease treatments ready for the clinic? – Science Magazine

Posted: October 7, 2019 at 1:46 pm

Regenerative medicinewhich involves regrowing damaged or dysfunctional cells, tissues, and organs, in order to treat and cure human diseaseholds great promise. Discoveries in stem cell research and tissue engineering as well as advances in regulatory and industry support have brought regenerative medicine treatments closer than ever to the clinic. Two areas showing particular potential are diabetes and vascular disease. Whether acquired or congenital, diabetes afflicts millions of people worldwide and presents a tremendous burden both in terms of physical deterioration and loss of economic capacity. Current treatments rely mainly on lifetime injections of exogenous hormones and palliative treatments with pharmaceuticals, neither of which can address the lack of properly functioning beta cells in the pancreas. Similarly, vascular diseases are among the leading causes of mortality and morbidity. The ability to generate new, clinical-grade vascular tissue is critical to the long-term treatment of complications arising from ischemic injury, stroke, aneurisms, retinopathy, and other acute and chronic vascular conditions; significant progress has been made in using stem cell sources to produce this tissue. But what is needed to get such potentially transformative treatments over the finish line?

During this webinar, the speakers will:

This webinar will last for approximately 60 minutes.

University of Miami Miller School of MedicineMiami, FL

Juan Domnguez-Bendala, Ph.D., is director of the Stem Cell Development for Translational Research and research associate professor of surgery at the Diabetes Research Institute (DRI), University of Miami Miller School of Medicine. Before joining the DRI faculty, he worked at the Roslin Institute (Scotland, United Kingdom) under the supervision of one of the creators of Dolly the sheep. He obtained his Ph.D. there and acquired considerable experience in embryonic stem cell research and state-of-the-art genetic engineering techniques. Working with other DRI faculty and international collaborators, Dr. Domnguez-Bendala is currently involved in several projects that focus on the use of stem cells to obtain pancreatic islets that could be safely and efficiently transplanted into patients with type 1 diabetes. He is also working on new methods for the endogenous regeneration of pancreatic beta cells.

Mayo ClinicRochester, MN

As deputy director of Translation for the Center for Regenerative Medicine, medical director of the Advanced Product Incubator, and director of the Van Cleve Cardiac Regenerative Medicine Program at the Mayo Clinic in Rochester, Minnesota, Dr. Behfar has worked to establish off-the-shelf good manufacturing practice (GMP)-grade regenerative technologies. Over the last two decades, his program has engaged in evaluating cell-based technologies for restoration of skeletal and cardiac muscle function. During this time, he initiated clinical trials in heart failure along with Dr. Andre Terzic, using stem cells to restore cardiac function and treating over 400 patients. Through that experience, it was discovered that exosome secretion was the primary driver of the regenerative action of stem cells. More specifically, an exosome product was purified (termed purified exosome product, or PEP) from our regenerative platform that revealed massive biopotency in activating regeneration through mitogenic, antioxidant, anti-inflammatory and provasculogenic influence. This discovery now serves as the basis for many preclinical and clinical efforts at Mayo Clinic.

Science/AAASWashington, D.C.

Dr. Oberst did her undergraduate training at the University of Maryland, College Park, and her Ph.D. in Tumor Biology at Georgetown University, Washington D.C. She combined her interests in science and writing by pursuing an M.A. in Journalism from the Philip Merrill College of Journalism at the University of Maryland, College Park. Dr. Oberst joined Science/AAAS in 2016 as the Assistant Editor for Custom Publishing. Before then she worked at Nature magazine, the Howard Hughes Medical Institute, The Endocrine Society, and the National Institutes of Mental Health.

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Exploring Regenerative Medicine in Microgravity Aboard the International Space Station – UPJ Athletics

Posted: October 7, 2019 at 1:46 pm

Learning how everyday things work in space, such as how to effectively brush teeth or how hair grows, is intriguing, but knowledge of how medical research translates from Earth's surface to above its atmosphere is limited.

A new alliance between the McGowan Institute for Regenerative Medicine at the University of Pittsburgh and the International Space Station (ISS) U.S. National Laboratory aims to drive the progress of regenerative medicine research in microgravity environments specifically, aboard the ISS.

The questionis What can we do in space that we can't do on Earth that makes a difference?" said William Wagner, director of the McGowan Institute. "That's a pretty exciting question, because it's currently unanswered; we don't know what the key value of microgravity is. I think when we find that, we can attract investment, we're going to begin to identify what the most promising technology is."

The ISS National Laboratory and the McGowan Institute will collaborate with partners from industry as well as other academic research centers and government agencies to drive the progress of regenerative medicine research aboard the ISS. As part of this alliance, Pitt will develop facilities on campus to advance research and meet with potential partners, while working in coordination with the ISS National Laboratory on flight opportunities to the orbiting laboratory. The program will focus on microgravity life sciences research and development, with a line of sight toward products and services for clinical application on Earth.

"What has to happen now is knowing how we can leverage research into a treatment or technology that someone will invest in because it will replace the current way we do things here on Earth," Wagner said. "We are very enthusiastic about this, because we believe the time is right to move from the observational to the more practical, moving things toward commercialization. One of the things we're going to try to do is give industry the best and brightest research in our country, not just at Pitt, but other universities as well, to pitch different concepts and partner with those concepts to help develop them."

An example of this research in action could include exploiting the unique behavior of stem cells in microgravity in order to improve cell-based therapies for a variety of diseases and impairments, such as traumatic brain injury and type I diabetes. Similarly, microgravity could allow 3D printers to create complex tissue structures that are difficult to achieve in the presence of full gravity.

This alliance a core element of the ISS National Laboratory Industrial Biomedicine Program was unveiled at the 8th annual ISS Research and Development Conference held in Atlanta earlier this year.

University leaders are optimistic this alliance will be the next big step in space research and commercialization.

The McGowan Institute has built on its deep history advancing the development of artificial organs to establish a position of internationally recognized leadership in regenerative medicine, said Rob A. Rutenbar, senior vice chancellor for research at Pitt. The ISS National Laboratory will benefit from that deep expertise, as well as our commitment to rapid clinical translation.

The products of the Industrial Biomedicine Program will help build the fundamental business case for the industrialization of crewed platforms in low Earth orbit. In future alliances, the ISS National Laboratory will work with companies and research partners who seek to find solutions to common problems on Earth through space-based experimentation on the ISS National Laboratory.

The ISS National Laboratory is proud to announce this alliance with Pitt and McGowan in order to develop biomedical products in space that could benefit human health on Earth, said ISS National Laboratory Chief Strategy Officer Richard Leach. Part of the role of the ISS National Laboratory is to create and implement innovative strategies to enhance the research capacity of the orbiting laboratory, and we believe alliances like this will pave the way for future collaborations to advance the discoveries of space-based science.

More details about the alliance are available on the ISS National Laboratorys website.

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AIVITA Biomedical to Present at Meeting on the Mesa and Other Investor, Oncology and Regenerative Medicine Conferences in October – PRNewswire

Posted: October 7, 2019 at 1:46 pm

IRVINE, Calif., Oct. 1, 2019 /PRNewswire/ -- AIVITA Biomedical, Inc., a biotech company specializing in innovative stem cell applications, today announced that it will be presenting at the following investor, oncology and regenerative medicine conferences in October:

Cell & Gene Meeting on the Mesa Company Presentation Time: October 2, 11:00 AM PST Location: Park Hyatt Aviara Resort Golf Club & Spa, Cognate in the Bioservices Ballroom, Carlsbad, CA

World Immunotherapy Congress Keynote Title: Enhancing patient responses with autologous cancer stem cell vaccine in combination with checkpoint inhibitors Time: October 16, 9:25 AM CET Location: Congress Centre Basel, Basel, Switzerland

BIO Investor Forum Company Presentation Time: October 23, 10:15 AM PST Location: Elizabethan A, The Westin St. Francis,San Francisco, CA

World Vaccine Congress Talk Title:Autologous Cancer Stem Cell Vaccines for Solid Tumor Cancers When: October 29, 3:45 PM CET Location: Palau de Congressos de Catalunya, Barcelona, Spain

About AIVITA Biomedical AIVITA Biomedical is a privately held company engaged in the advancement of commercial and clinical-stage programs utilizing curative and regenerative medicines. Founded in 2016 by pioneers in the stem cell industry, AIVITA Biomedical utilizes its expertise in stem cell growth and directed, high-purity differentiation to enable safe, efficient and economical manufacturing systems which support its therapeutic pipeline and commercial line of skin care products. All proceeds from the sale of AIVITA's skin care products support the treatment of women with ovarian cancer.

SOURCE AIVITA Biomedical, Inc.

http://aivitabiomedical.com

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AIVITA Biomedical to Present at Meeting on the Mesa and Other Investor, Oncology and Regenerative Medicine Conferences in October - PRNewswire

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BrainStorm Announces Notice of US Patent Allowance for NurOwn Cellular Therapeutic Technology Platform – Yahoo Finance

Posted: October 7, 2019 at 1:46 pm

NEW YORK, Oct. 07, 2019 (GLOBE NEWSWIRE) -- BrainStorm Cell Therapeutics Inc.(NASDAQ: BCLI), a leading developer of adult stem cell therapeutics for neurodegenerative diseases, today announced that the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance for BrainStorm's new US Patent Application, number: 15/113,105, titled: Method of Qualifying Cells'.

The allowed claims cover a pharmaceutical composition for MSC-NTF cells secreting neurotrophic factors (NurOwn) comprising a culture medium as a carrier and an isolated population of differentiated bone marrow-derived MSCs that secrete neurotrophic factors.

Patent families protecting NurOwn have previously issued in the United States, Japan, Europe, Hong-Kong and Israel.

"This allowance further expands the patent protection of the NurOwn Cellular Therapeutic Technology Platform and enables us to accelerate clinical development for new neurodegenerative indications, commented BrainStorm President and CEO,Chaim Lebovits.

About NurOwn

NurOwn (autologous MSC-NTF) cells represent a promising investigational therapeutic approach to targeting disease pathways important in neurodegenerative disorders. MSC-NTF cells are produced from autologous, bone marrow-derived mesenchymal stem cells (MSCs) that have been expanded and differentiated ex vivo. MSCs are converted into MSC-NTF cells by growing them under patented conditions that induce the cells to secrete high levels of neurotrophic factors. Autologous MSC-NTF cells can effectively deliver multiple NTFs and immunomodulatory cytokines directly to the site of damage to elicit a desired biological effect and ultimately slow or stabilize disease progression. BrainStorm is currently conducting a Phase 3 pivotal trial of autologous MSC-NTF cells for the treatment of amyotrophic lateral sclerosis (ALS). BrainStorm also recently received U.S. FDA acceptance to initiate a Phase 2 open-label multicenter trial in progressive MS and enrollment began in March 2019.

About BrainStorm Cell Therapeutics Inc.

BrainStorm Cell Therapeutics Inc. is a leading developer of innovative autologous adult stem cell therapeutics for debilitating neurodegenerative diseases. The Company holds the rights to clinical development and commercialization of the NurOwn technology platform used to produce autologous MSC-NTF cells through an exclusive, worldwide licensing agreement. Autologous MSC-NTF cells have received Orphan Drug status designation from the U.S. Food and Drug Administration (U.S. FDA) and the European Medicines Agency (EMA) in ALS. BrainStorm is currently enrolling a Phase 3 pivotal trial in ALS (NCT03280056), investigating repeat-administration of autologous MSC-NTF cells at six sites in the U.S., supported by a grant from the California Institute for Regenerative Medicine (CIRM CLIN2-0989). The pivotal study is intended to support a filing for U.S. FDA approval of autologous MSC-NTF cells in ALS. BrainStorm also recently received U.S. FDA clearance to initiate a Phase 2 open-label multicenter trial in progressive Multiple Sclerosis. The Phase 2 study of autologous MSC-NTF cells in patients with progressive MS (NCT03799718) started enrollment in March 2019. For more information, visit the company's website at http://www.brainstorm-cell.com

Safe-Harbor Statements

Statements in this announcement other than historical data and information constitute "forward-looking statements" and involve risks and uncertainties that could cause BrainStorm Cell Therapeutics Inc.'s actual results to differ materially from those stated or implied by such forward-looking statements. Terms and phrases such as "may", "should", "would", "could", "will", "expect", "likely", "believe", "plan", "estimate", "predict", "potential", and similar terms and phrases are intended to identify these forward-looking statements. The potential risks and uncertainties include, without limitation, risks associated with BrainStorm's limited operating history, history of losses; minimal working capital, dependence on its license to Ramot's technology; ability to adequately protect the technology; dependence on key executives and on its scientific consultants; ability to obtain required regulatory approvals; and other factors detailed in BrainStorm's annual report on Form 10-K and quarterly reports on Form 10-Q available at http://www.sec.gov. These factors should be considered carefully, and readers should not place undue reliance on BrainStorm's forward-looking statements. The forward-looking statements contained in this press release are based on the beliefs, expectations and opinions of management as of the date of this press release. We do not assume any obligation to update forward-looking statements to reflect actual results or assumptions if circumstances or management's beliefs, expectations or opinions should change, unless otherwise required by law. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements.

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