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Trans army veteran gets 42JJ breast enhancement to ‘express her femininity’ – Mirror Online

Posted: October 9, 2019 at 2:55 pm

A trans woman who served 11 years in the US military before transitioning has had surgery to get giant 42JJ breasts.

Maxine Montoya, 38, said she wanted to express her femininity in a way thats right up front".

And she said she is considering getting even larger implants.

Maxine, from San Diego, California, said: I could talk about my boobs all day, I couldnt be happier with the results I got from my breast augmentation.

Why this big? I see this as something empowering. That exaggeration of femininity and what it represents. I sometimes wonder if I want to get bigger.

Before transitioning, Maxine was married and had a daughter, Mia, who still calls her Dad and came out at the age of nine.

She said: I see no reason why a trans woman cant be a father - Im still her father, Im just a woman and a dad."

Her daughter added: There was never any need for me to change what I call my dad because my dad always said I fathered you, so you can continue to call me by that name.

Mia came out as bisexual at a young age and said that having a transgender parent really helped understand her true self.

She said: Being bisexual and having a trans parent around helped immensely.

If my dad hadnt transitioned, I probably wouldnt have come out as soon as I did without the other LGBTQ figure in my life who I knew was going to love me no matter what.

Maxine thinks she would have also transitioned earlier if she had been surrounded by the same positive influences as her daughter.

She said: I was raised in a very sheltered, conservative household.

With all the information thats available now on the internet, if I had that I probably would have done this a lot sooner.

Recalling her time in the armed forces, Maxine said: My mother wanted me to join the military, I honestly dont have very fond memories of my experiences there.

I was in a culture that did not accept me.

Although she left the military before transitioning, Maxine was still in service when she started cross dressing.

I didnt come out as transgender in the military, however that doesnt mean that I didnt experience dysphoria, she said.

I was wearing a skirt and some makeup, and I was walking around, word of that got back to someone in my chain of command and I ended up receiving what were flat out threats against my career.

I asked myself this question: Do I ever want to be perceived as male? And the answer was an immediate no.

Maxine has now been on Hormone Replacement Therapy for over a year and a half and has never been happier.

She said: It just changed everything in a way that I could never have anticipated, it has made a world of difference in the way I feel.

However, in order to reduce the dosage of testosterone blockers or even come off them completely, Maxine is currently planning to get bottom surgery too.

I am getting whats called an orchiectomy - you have the testicles removed, and I have zero attachment to those girls so they can go.

My doctors told me that if I get those removed, she can probably lower my dosage of testosterone blockers or take me off it completely.

Maxine speaks with frustration about the misconceptions that other people have of her,

She said: People assumed that I am attracted to men because Im female, but Im gay - people dont understand that, they cant separate gender from sexuality.

Maxine is in a committed relationship with her partner Melissa, who has muscular dystrophy. Maxine is her full-time carer.

Maxine added: Im a caregiver for my partner and that brings me a lot of joy.

Unfortunately, the couple have to face a lot of judgement and prejudice directed at their inter-abled love.

Maxine said: Nobody wants to assume we are a couple; I can kiss her in public and people are looking at us just trying to understand what this means and how does this happen.

But the two go back over 20 years, when they met through a common friend in high school.

Melissa said: In high school she was always very feminine and thats one of the qualities I loved about her, she was my best friend.

When they are out in public, they often receive looks and stares.

A lot of people look at it negatively, theres nothing to say to those people, said Maxine.

Maxine even seems to somewhat enjoy the negative looks.

The attention, I love it all, theres nothing I dont appreciate, both positive and negative - Im not dressing this way to blend, I dress to stand out so if I get negative glares, its just kind of validating, she said.

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Tesco and Sainsburys among UK supermarkets to be hit by worldwide ibuprofen shortage – The Sun

Posted: October 9, 2019 at 2:55 pm

SUPERMARKETS are running out of ibuprofen pills due to a worldwide shortage.

Customers say they are increasingly finding empty shelves when they try to buy the painkiller.

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Many are buying paracetamol instead causing that drug to be in short supply in some areas. News of the shortages comes in the wake of reports that chemists are running low on some prescription drugs.

Tesco said the problem was due to a global shortage of the active ingredient in ibuprofen medicine. It said both own-brand and some branded products are affected.

The supermarket said it was working with suppliers to manage the shortage and aims to have full availability within the next two weeks.

Sainsburys is also having problems, with a spokesman saying stocks of own-brand ibuprofen and paracetamol were running low.

The store has put up notices informing customers of supply issues.

Customers have reported scouring supermarkets for ibuprofen but finding only more costly brands.

A customer named Michelle tweeted: Over the past couple of weeks I have tried to buy in Boots, Superdrug and Tesco without success.

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The shelves are either empty or filled up with expensive brand alternatives.

The shortages of prescription drugs, including hormone replacement therapy, antidepressants and anti-epilepsy pills, are thought to be caused by production problems and stockpiling ahead of Brexit.

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Tesco and Sainsburys among UK supermarkets to be hit by worldwide ibuprofen shortage - The Sun

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The menopause made my wifes sex drive disappear but she uses my erection problems as an excuse – The Sun

Posted: October 9, 2019 at 2:55 pm

DEAR DEIDRE: IM having erection problems because I fear my wife is not attracted to me sexually.

Weve attempted sex only three times in the past five years successfully just once.

Weve been married very happily for 40 years but my wifes healthy sexual appetite has disappeared.

Im 65 and she is 62. She had hormone replacement therapy when she went through the menopause.

I love her but feel my erection problems suit her just fine.

DEIDRE SAYS: Sexual responsiveness can suffer from the menopause but the HRT should have helped.

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I doubt this crisis is wholly about that. Ask what changes you could make in your relationship as a whole, or in how you make love that would make her happier.

Then she may be more responsive to your needs.

My e-leaflet Love And The Mature Woman can help you both with this.

Get in touch with Deidre today

Got a problem?

Send an email to problems@deardeidre.org. Every problem gets a personal reply, usually within 24 hours weekdays.

You can also send a private message on the DearDeidreOfficial Facebook page.

Follow me on Twitter @deardeidre.

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Hormone Replacement Therapy Market to Register a Stout Growth by 2028 – Space Market Research

Posted: October 9, 2019 at 2:55 pm

The hormone replacement therapy market is foreseen to expand at a significant pace withsales of hormone replacement therapy products crossing US$ 12,000 Mn by 2019 end. Rising incidences of osteoporosis fractures coupled with growing menopause rates among women have remained instrumental in driving the demand for hormone replacement therapy. Fact.MR envisages that thedemand for hormone replacement therapy is projected to expand at a CAGR of 6.0% in terms of valuethroughout the period of forecast, 2018-2028.

Disorders associated with hormonal imbalance continue to influence the use of hormone replacement therapy worldwide. Hormone replacement therapy demand is further pushed with macroeconomic aspects such as growing geriatric population and significant increase in healthcare expenditure worldwide. Growing age directly impacts secretion of hormones such as progesterone and estrogen in women, which is expected to trigger the use of estrogen hormone replacement therapy.

Expanding range of menopausal window (45-55 years) coupled with growing number of postmenopausal patients are few of the key factors influencing the growth of thehormone replacement therapy market. According to the report, thedemand for estrogen hormone replacement therapy is expected to grow on the back of growing menopausal rate worldwide. The sales of estrogen hormone replacement therapy are likely to surpass US$ 18,000 Mn by 2028, higher than those of other hormone replacement therapy products including thyroid and growth hormone related hormone replacement therapy products, says the report.

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Sales of hormone replacement therapy products through hospital pharmacies and retail pharmacies are likely to be on an upswing with developers of hormone replacement therapy products relying on these channels than online selling. Retail pharmacies are expected to remain an attractive distribution channel for hormone replacement therapy products, with sales accounting for a larger revenue share of the overall hormone replacement therapy market. The sales of hormone replacement therapy through clinics are projected to grow at a steady during the 2018-2028 timeline.

The hormone replacement therapy market is expected to remain influenced by increasing government support apropos to womens health. Governments and non-profit organizations of various countries are spreading awareness regarding hormone replacement therapy along with providing free treatments to lower and middle class people. Regulatory authorities such as FDA are also contributing to the cause of supporting womens health by launching initiatives such as Take Time To Care (TTTC) programs. This aspect is likely to support the growth of the hormone replacement therapy market in the coming years.

Sales of hormone replacement therapy products are likely to remain concentrated among developed countries of North America and Europe. Tug-of-war between North America and Europe apropos to demand for hormone replacement therapy has been witnessed since the past couple of years, with the latter gaining tempo over the former, says the report.

Stakeholders in the hormone replacement therapy can find attractive opportunities in developed countries in North America, particularly the United States. According to the American Congress of Obstetricians and Gynecologists, around 6,000 women reach menopause every day, reaching a count of over 2 million annually. This has translated into significant adoption of hormone replacement therapy in the country. The demand for hormone replacement therapy in the US is also accompanied by higher GDP per capita, triggering high healthcare expenditure.

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The report also foresees that the hormone replacement therapy market in Asia Pacific excluding Japan (APEJ) region is poised to expand at a relatively higher pace as compared to other regions. According to the report, the APEJ hormone replacement therapy market is projected to expand at a stellar pace of 7.2% during the assessment period. This growth can be attributed to increasing population coupled with higher life expectancy in emerging economies such as India and China. Against this backdrop, stakeholders in hormone replacement therapy market can expect optimistic growth in the region in the years to follow, leveraging its lucrativeness from an investment standpoint.

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Hormone Replacement Therapy Market Global Industry to Gain High Market Share During the Forecast Period 2019-2025 – Space Market Research

Posted: October 9, 2019 at 2:55 pm

ResearchMoz present a comprehensive research report namely Global Hormone Replacement Therapy Market Size, Status and Forecast 2019-2025 which reveals an extensive analysis of global industry by delivering the detailed information about Forthcoming Trends, Customers Expectations, Technological Improvements, Competitive Dynamics and Working Capital in the Market. This is an in-depth study of the market enlightening key forecast to 2025.

The market study on the global market for Hormone Replacement Therapy examines current and historical values and provides projections based on accumulated database. The report examines both key regional and domestic markets to provide a conclusive analysis about the developments in the Hormone Replacement Therapy market over the forecast period.

Get Free Research Summary of The Report: https://www.researchmoz.us/enquiry.php?type=S&repid=2081850

This report covers leading companies associated in Hormone Replacement Therapy market:

Scope of Hormone Replacement Therapy Market:The global Hormone Replacement Therapy market is valued at million US$ in 2017 and will reach million US$ by the end of 2025, growing at a CAGR of during 2018-2025.

This Market Report includesdrivers and restraints of the global Hormone Replacement Therapy market and their impact on each region during the forecast period. The report also comprises the study of current issues with consumers and opportunities. It also includes value chain analysis.

On the basis on the end users/applications,this report focuses on the status and outlook for major applications/end users, sales volume, Hormone Replacement Therapy market share and growth rate of Hormone Replacement Therapy foreach application, including-

On the basis of product,this report displays the sales volume, revenue (Million USD), product price, Hormone Replacement Therapy market share and growth rate ofeach type, primarily split into-

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Hormone Replacement Therapy Market: Regional analysis includes:

Hormone Replacement Therapy Market Report Structure at a Glance:

For More Information Kindly Contact: ResearchMozMr. Nachiket Ghumare,90 State Street,Albany NY,United States 12207Tel: +1-518-621-2074USA-Canada Toll Free: 866-997-4948Email: [emailprotected]Follow us on LinkedIn @ http://bit.ly/1TBmnVGFollow me on : http://marketresearchlatestreports.blogspot.com/

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Am I going through the menopause? Dr Mary Ryan shares the symptoms to look out for – RSVP Live

Posted: October 9, 2019 at 2:55 pm

Education around hormonal health is sadly lacking, with many women thinking they are suffering from depression or dementia when actually they are entering the menopause.

Here, Dr Mary Ryan explores the difference between perimenopause and menopause, the various symptoms involved, treatments available and a new surgery which could actually delay the menopause by up to 20 years.

For some women, the first clue they have been experiencing symptoms of the menopause is after they arrive at the doctors surgery, fearful that something is gravely amiss.

Women often think they are suffering from depression. And I have patients coming to me saying, Doctor, my memory is gone, am I getting dementia? But in fact it is all down to hormonal imbalance as they enter the menopause.

Women of my mothers generation never discussed menopause, they suffered dreadfully and were supposed to put up and shut up. But menopause is something all women should discuss and the stigma needs to go. Too many women struggled in the past, which was wrong and unnecessary.

Perimenopause Vs Menopause

Perimenopause begins several years before menopause, as the ovaries gradually begin to make less oestrogen. Perimenopause usually starts in a womans 40s, but can start as early as your 30s. The transition phase to menopause may last four to eight years and it is very important that during this time of hormone imbalance that women pace themselves and listen to their bodies requirements as this helps with hormone regulation. Menopause officially kicks in when the ovaries produce so little oestrogen that eggs are no longer released, also causing your periods to stop.

Symptoms

The symptoms for perimenopause and menopause are extremely similar. The key difference is in their severity. Typically symptoms include: mood swings, depression, brain fog, hot flushes, sleeplessness, vaginal dryness, reduced energy, bloating, aches and pains and reduced sex drive.

Hormone Health Is Key

The decrease in oestrogen and progesterone that occurs in menopause can result in a reduction in your immune function.

Oestrogen and progesterone are also thought to play a role in autoimmune diseases where the immune system attacks the body, meaning menopausal women may be more susceptible to autoimmune disease. In addition, menopause results in a decrease in T cells, which are a key part of the immune system, and help destroy cancer cells, fight bacteria and orchestrate the immune response throughout the body.

Not only do womens immune systems become compromised during the menopause, but their mental health may suffer too. Oestrogen acts to increase your happy hormone, serotonin, as well as your memory neurotransmitter.

As these levels begin to fluctuate, your hormone levels also fluctuate affecting your mood, memory and your bodys energy levels.

This is wrongly labelled depression when it is actually a hormone imbalance that can often settle with no medication and a good support structure.

Has My Period Gone For Good?

Periods become irregular during the perimenopause. However, not having a period for six months doesnt mean it wont return. I always tell women to carry pads with them even when their periods are irregular because they could suddenly have a deluge. Perimenopause can start when youre about 47, and your cycle could remain irregular until you are 53 or 55, so it may be a long time before youre through it.

Am I Going Through The Menopause?

The only way to accurately confirm you are perimenopausal is to visit your GP. Women can have their hormones tested by their doctor and get the full basic tests of bloods including the hormones that control periods FSH and LH and the thyroid hormone to rule out any underlying conditions and confirm the menopause.

Treatment

Early intervention is key. Perimenopause is just the start and women who look after themselves at this stage will have a much easier menopause. Depending on the severity of your symptoms, a combination of diet, supplements and medication may be helpful. In my experience, 50 per cent of women do well after making some lifestyle changes, through healthy eating and natural supplements. In addition to the above, 30 per cent need medication for peripheral nerve pain and autonomic symptoms, and the remainder may need HRT. Everyone is different.

Diet And Supplements

Soya products are great sources of oestrogen. Both Omega 3 and B vitamins are also of benefit at this time. Vitamin B6 contributes to the regulation of hormonal activity and along with vitamins B1 and B12, it also contributes to normal psychological function. Vitamin D3 is important for bone health as we age, as osteoporosis can become an issue for women as their oestrogen decreases. I like supplements like Cleanmarine which contain everything you need.

Hormone Replacement Therapy (HRT)

For patients with chronic symptoms, HRT can be a life changer. I reserve HRT for the women who come in profusely sweating which, thankfully, is only about 20 per cent. My preference is to prescribe the patch: you are getting the minimal amount and it is not as highly concentrated, which works very well for almost all of the women who try it. When prescribing HRT, I will always do a mammogram even if there is no history of breast cancer to ensure there is nothing there. I always inform women on the slight risk of breast cancer new research indicates it increases your risk by four per cent. However, this doesnt give any indication of whether there are other factors such as obesity. Some eight per cent of breast cancer is caused by excessive weight, and eight per cent is caused by excessive alcohol. Both of these figures pose a far more significant threat than HRT.

At the end of the day it has to be about the womans quality of life and she has to be trusted to make an informed decision.

A lot of women are now asking about bioidenticals a natural form of oestrogen but for me there isnt enough research yet.

Postponing The Menopause

A first-of-its-kind surgery is now being piloted which could delay the menopause by up to 20 years. The procedure involves removing a portion of a womans ovaries and then cryogenically freezing it. If this is safe then it will be wonderful and will offer working women a choice while taking some of the pressure off their shoulders. It would also allow women to hold onto their collagen production for much longer, however we dont have enough evidence to assure us of its safety just yet.

Stress And Self Love

Women need to listen to their bodies and rest more to allow the hormone control centre to cope better. Those who go into menopause pacing themselves and eating healthily fare much, much better. Your body is wonderful at adapting to change once we allow it to rest and be healthy.

Women need to realise that once they lose the protective effect of oestrogen in menopause they are at risk of heart disease so it is important that they keep their weight and blood pressure normal during this time and also look after their bone health.

I advise all my patients to listen to their bodies: when they are tired, they must rest. We plug in our mobile phones when they are in the red, but we must also do the same with ourselves.

We need to empower women to put themselves first and look after their wellbeing. After all, menopause is only the next chapter in their lives. It is part of a normal evolution and women can look forward to the next 40 years with vigour provided they take care of their health.

Dr Mary Ryan, consultant endocrinologist, will be a guest speaker at The M Word, Irelands first major conference on the menopause, on October 11 in Dublin.

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‘Easily misunderstood’: 4 things to know about epigenetics, including the fact that most changes are not passed on to offspring – Genetic Literacy…

Posted: October 9, 2019 at 2:53 pm

The concept of epigenetics is one that is easily misunderstood and even misused. This is obvious from premature claims that we epigenetically inherit the trauma of our ancestors or that epigenetics explains so-called past-life experiences. With epigenetics being increasingly evoked online and in the pages of the latest bestsellers, its important to explore what is actually known about the topic. While New Age entrepreneurs such as Deepak Chopra speak with confidence about being able to harness the powers of the epigenome for the benefits of human health, we need to keep in mind that far more is unknown about epigenetics than is known. Lets have a look at what we do know.

Firstly, without the epigenome human bodies simply would not be. Each one of our somatic (body) cells has the same genes, yet not all of these genes are active all at once or in the same ways. If they were, each cell would be the same in both form and function. Instead, the bodys organs and organ systems are composed of highly specialized cells each cell type has unique functions, appearance, and metabolic activity. In the case of muscle cells, for example, undifferentiated cells in the human embryo receive a become muscle signal. These cells respond by epigenetically activating specific genes and turning others off, which sets them on a direct course to becoming muscle cells. Other cells receive different signals to become one of around 200 other human cell types (such as liver, skin, or fat cells).

The epigenome is basically an additional layer of genetic information that controls or mediates specific cellular behaviors and transcription activity. Some liken the epigenome to software while the genome is the hardware. The main types of epigenetic mechanisms or marks include DNA methylation and histone modification. Epigenetic marks are established very early in development and function by shielding sections of DNA from transcription machinery or exposing sections of DNA to transcription machinery. Shielded DNA is synonymous with the off position while exposed DNA is synonymous with the on position. Once the marks are established, each cell will pass its same epigenetic state to new cells, thus maintaining cellular identity and function.

Some parts of the epigenome appear to be susceptible to environmental or external influence, but not all sections of the epigenome are equally vulnerable. The epigenetic state of cells can be altered in response to environmental factors such as excessive stress, abuse, poor diet, pollution, and smoking sometimes with beneficial or protective outcomes and sometimes with detrimental or destructive consequences. Harmful epigenetic changes have been observed in cancer and in cardiovascular, autoimmune, metabolic, and neurodegenerative diseases. Though some studies suggest that certain epigenetic changes may be reversed by chance or with intervention, epigenetic alterations tend to be stable once they are established and are then passed on through cell division within the individuals body. This suggests that preventing harmful epigenetic changes is a better strategy than trying to reverse them once they occur.

An individuals epigenome is particularly sensitive during gestation (while in the womb) and right after birth. This may explain why a womans use of alcohol or drugs during pregnancy can do so much damage to the unborn child, in the form of such conditions as fetal alcohol spectrum disorders (FASD). It may also explain why the existence of obesity and other metabolic disorders in pregnant women can lead to a much greater chance of lifelong health problems (such as diabetes and heart disease) and premature death in their offspring. Intrauterine conditions permanently shape offsprings body function and structure, metabolism, and likelihood of developing certain diseases both in the short-term and in the long-term.

The vast majority of epigenetic changes only affect the individuals somatic or body cells, and are thus not transmitted to offspring. Lacal and Ventura refer to these epigenetic changes as direct epigenetics changes to the epigenome that occur over the lifespan of one person due to various experiences they have had, choices they have made, and environments in which they have found themselves. Good examples of direct epigenetics are seen in identical twins. Identical twins (aka monozygotic twins) have the same DNA, yet they rarely look exactly the same they may grow to be slightly different heights, have different body weights, develop wrinkles and gray hair at different times, and so on. And while one twin may develop a particular genetic illness or autoimmune disease, the other may remain disease-free. Identical twins rarely have the same health profiles, and usually develop illness, age-related disease, and mortality at different times. In fact, identical twins tend to die more than 10 years apart. The majority of these differences are due to variations in the twins epigenomes, which are themselves due to varied experiences and environmental exposures that the twins had throughout the course of their lives. Many point to these types of examples to illustrate the substantial influence of environment, upbringing, and lifestyle on an individuals health and general wellbeing.

While most epigenetic information is erased and reprogrammed before it can be passed on to offspring, some epigenetic information may escape erasure and may thus be passed on to an individuals children (and potentially to subsequent generations). In mammals, there are at least two main periods of demethylation and remethylation once during the development of germ cells (the precursor cells that will become sperm and eggs), and once in the earliest stages of an embryos development. During demethylation, ancestral methylation patterns (key epigenetic marks) are almost completely erased. The regions that are not demethylated may represent hot spots of transgenerational epigenetic inheritance, according to a 2019 research review on epigenetic regulation by Wang et al. Its important to note that there has not yet been clear evidence in humans of transgenerational epigenetic inheritance, and that the topic of how transgenerational epigenetic inheritance might work in humans is highly debated.

Interestingly, the epigenetic erasure and reprogramming that occur in germ cells and in the early embryo can be interrupted, disturbed, or altered by certain external forces. These external forces include the use of assisted reproductive technology, such as in vitro fertilization (IVF), and the health, lifestyles, and diets of both of the parents. In this way, conditions like obesity in males can negatively impact germ cells before they become sperm (in the process of spermatogenesis), thus potentially leading to conditions such as diabetes in the next generation. While it was once thought that the health status of fathers upon conception was not important in terms of the future health of their offspring, and the focus was almost solely on the health of mothers instead, research in epigenetics has clearly indicated that the health status and lifestyle choices of both parents is crucial to the wellbeing of their future children.

Kristen Hovet is an American-Canadian journalist and writer who specializes in the areas of psychology, health, science, and the intersection of sociology and culture. Follow her on Facebook or Twitter at @kristenhovet

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'Easily misunderstood': 4 things to know about epigenetics, including the fact that most changes are not passed on to offspring - Genetic Literacy...

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Global Epigenetics Market In-Depth Research Report Enabled with Respective Tables and Figures By Industry Experts – Sound On Sound Fest

Posted: October 9, 2019 at 2:53 pm

New York City, NY: October 3, 2019 Published via (Wired Release) Global Epigenetics Market Research Report is an in-depth and professional document 2019:

A newly published market study by MarketResearch.biz, titled Global Epigenetics Market, is built up with a step by step analysis from expert research. The report provides accurate estimation, improvement criterias, action plans, and root ways. It has covered emerging market trends, key challenges, restraints, opportunities, future growth potentials, competitive outlook, and regional outlook, and value chain analysis. The top players/vendors of the global market are further covered in the report. The report presents a pin-point breakdown of Epigenetics on the basis of type, applications, and research regions. The latest data has been presented on the revenue numbers, product details, and sale of key companies.

For Better Understanding Go With this Free Sample Report Enabled with Respective Tables and Figureshttps://marketresearch.biz/report/epigenetics-market/request-sample

It aims to help customers in the decision making process. The manufacturers data is covered that includes shipment, price, revenue, gross profit, and business distribution. With this report, all the manufacturers and the vendors will be in aware of the threats, shortcomings that the market will offer in the next few years. The current and prospective growth of the market for 2019-2028 is also captured. Graphical data is integrated in the form of charts, diagrams and tables making the report well organized and understandable for the professionals.

We Have includedVital insights into Epigenetics Market Competition and StrategiesofCompetitors :

Bio-Rad Laboratories Inc, Thermo Fisher Scientific Inc, Diagenode, QIAGEN, Abcam Plc., New England Biolabs, Agilent Technologies, Zymo Research, PerkinElmer Inc, Active Motif

Outlook ofEpigenetics Market Segmentation:

Global epigenetics market segmentation, by product:ReagentsKitsInstrumentsEnzymes

Global epigenetics market segmentation, by technology:DNA MethylationHistone ModificationsRNA-Associated Silencing

Global epigenetics market segmentation, by application:OncologySolid TumorsLiquid TumorsNon OncologyCardiovascular diseasesInfectious diseasesInflammatory diseaseMetabolic diseases

Global epigenetics market segmentation, by end user:Academic and Research InstitutesPharmaceutical and Biotechnology CompaniesContract Research Organizations

Regional Coverage:

All the regions and countries of the world are covered that also shows a regional development status, Epigeneticsmarket size, volume, and value, as well as price data. The global demand for the Epigenetics market has been fragmented across several regions such as

Americas (United States, Canada, Brazil, and Mexico)

Middle East and Africa (Egypt, South Africa, Israel, Turkey, GCC Countries)

Europe (Germany, France, UK, Italy, Russia Spain)

APAC (China, Japan, Korea, Southeast Asia, India, Australia)

South America (Brazil, Colombia, Argentina, etc.)

For Further Info and Any Query About Epigenetics Market, Place your Query Here!-https://marketresearch.biz/report/epigenetics-market/#inquiry

Main Features of The GlobalEpigeneticsMarket Research Report:

The report provides market values and anticipated growth rate of the global Epigenetics market for all years till 2028.

The report highlights the actual drivers of the market by considering risks and identifying and testing new tactics, manufacturing cost, raw material cost, downstream buyers, labor cost, and market channels.

The report assessed the market segments and provides the relative contribution to the development of the global Epigenetics market.

The report offers coverage of the competitive nature of the market and discusses various marketing strategies to stay ahead in the competition.

Its an essential tool to check the feasibility of a new project and geographical expansion of the company.

Browse Full Summary Research Report ofEpigeneticsMarket:https://marketresearch.biz/report/epigenetics-market/request-sample

There are 9 Chapters to deeply display the global Epigenetics market

Chapter One: Global Epigenetics Market Overview

1.1 Epigenetics Preface

Chapter Two: Global Epigenetics Market Analysis

2.1 Epigenetics Report Description

2.1.1 Epigenetics Market Definition and Scope

2.2 Epigenetics Executive Summary

2.2.1 Epigenetics Market Snapshot, [Segment 1]

2.2.2 Epigenetics Market Snapshot, [Segment 2]

2.2.3 Epigenetics Market Snapshot, [Segment 3]

2.2.4 Epigenetics Market Snapshot, [Region Segment]

2.3 Epigenetics Market Opportunity Analysis

Chapter Three: Global Epigenetics Market Dynamics

3.1 Drivers

3.2 Restraints

3.3 Opportunities

3.4 Trends

Chapter Four: Global Epigenetics Market Segment Analysis, by [Segment 1]

4.1 Epigenetics Overview

4.2 Epigenetics Segment Trends

4.3 Epigenetics Market Share and Forecast, and Y-o-Y Growth

Chapter Five: Global Epigenetics Market Segment Analysis, by [Segment 2]

5.1 Epigenetics Overview

5.2 Epigenetics Segment Trends

5.3 Epigenetics Market Share and Forecast, and Y-o-Y Growth

Chapter Six: Global Epigenetics Market Segment Analysis, by [Segment 3]

6.1 Epigenetics Overview

6.2 Epigenetics Segment Trends

6.3 Epigenetics Market Share and Forecast, and Y-o-Y Growth

Chapter Seven: Global Epigenetics Market Segment Analysis, by [Region Segment]

7.1 Epigenetics Overview

7.2 Epigenetics Regional Trends

7.3 Epigenetics Market Share and Forecast, and Y-o-Y Growth

Chapter Eight: Global Epigenetics Market Company Profiles

8.1 Companies

8.1.1 Company Overview

8.1.2 Product Portfolio

8.1.3 Financial Overview

8.1.4 Key Developments

8.1.5 SWOT Analysis

Chapter Nine: Global Epigenetics Market

9.1 Research Methodology

9.2 About Us

It further demonstrates a comprehensive view of the marketplace with subsequent information. The latest mechanical enhancements and new releases delivered in the report will help customers settle on taught business decisions and complete their requisite executions in the future. In the conclusion part of this report, you will find research findings, market size, worldwide market share, consumer needs along with customer preference change, and data source.

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Global Epigenetics Market In-Depth Research Report Enabled with Respective Tables and Figures By Industry Experts - Sound On Sound Fest

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Challenges in Developing Therapeutics for Addiction and Pain – Clinical Pain Advisor

Posted: October 9, 2019 at 2:52 pm

In light of the rapid increases in opioid overdose deaths, there is an urgent need to develop better treatment options for pain and addiction, according to a summary of key messages and discussion from a 2-day event titled The Opioid Crisis and the Future of Addiction and Pain Therapeutics: Opportunities, Tools, and Technologies Symposium, held at the National Institutes of Health in Gaithersburg, Maryland, which was published in the Journal of Pharmacology and Experimental Therapeutics.

In order to develop new pain treatments, it is imperative to have a better understanding of the circuits, pathways, genetics, transcriptional and epigenetic mechanisms, and targets involved in both pain and opioid addiction.

Opioid misuse and addiction now represent a public health crisis with a debilitating social and economic impact on individuals, and associated mortality. The symposium aimed to address concerns regarding pain and addiction and was unique in that it brought together experts from 2 research disciplines: addiction and pain.

Attempts to identify novel targets that could lead to effective pain treatments without involvement of the -opioid receptor were unsuccessful and only a limited number of targets exist for pain management, most which have been known for decades. It is important to recognize the complexity and diversity of pain and the pain experience, involving distinct mechanisms that require different therapeutic interventions.

Although drugs that have the potential for misuse initially act at the synapses, addiction requires repeated drug exposure and can therefore be considered drug-induced neural plasticity that involves changes in gene expression. Approximately half of the risk for addiction is thought to be due to genetic factors, with hundreds of genes each contributing a small fraction, and half due to environmental factors.

Negative emotional states cause physical and emotional pain that may act as a driving force in addiction. There is significant overlap in the neural pathways that mediate negative emotional states (eg, hyperkatifeia) and pain.

Natural products, including capsaicin, menthol, isothiocyanates, and thiosulfinates, elicit irritation or pain by activating nociceptors. Studies examining the mechanisms of action of these compounds led to the identification of transient receptor potential (TRP) ion channels that represent promising targets for novel analgesics. Current work aims at identifying antagonist molecules to TRP channels that may represent alternatives to opioid analgesics.

Research into venomous toxins, including Hm1a/b spider toxins, has revealed a role for the Nav1.1 voltage-gated channel in pain. Cannabinoids and the opioid receptor agonist mitragynine (derived from kratom) are also gaining attention as potential targets for pain.

Efforts to identify inhibitors selective for the Nav1.7 channel have proved challenging due to factors that include the IC50 value of the receptor being inferior to concentrations required to block action potentials in nociceptors.

-opioid receptor antagonists may represent an effective therapeutic strategy to alleviate the affective dimension of chronic pain, as these can restore dopamine release.

Digital therapeutic options also lead to effective chronic pain therapy. With the use of data derived from smartphones, connected sensors, wearables, and voice input, there is the potential to better assess and understand a patients health and to identify biomarkers. Finally, behavioral epigenetics can be used to understand the interplay between life experience and brain function.

Given the rapidly growing occurrence of opioid use disorder and associated overdose deaths, as well as the lengthy time required for new targets to reach patients in need, there is a renewed urgency to develop better treatments for pain and addiction, concluded the authors.

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Reference

Coussens NP, Sittampalam GS, Jonson SG, et al. The opioid crisis and the future of addiction and pain therapeutics [Published online September 3, 2019]. J Pharmacol Exp Ther. doi: 10.1124/jpet.119.259408

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This is Hollywood’s deadliest action star – We Are The Mighty

Posted: October 9, 2019 at 2:52 pm

Hollywood is really, really good at killing the bad guys. And even though they haven't quite gotten to ISIS just yet, there is a trail of bloody, dismembered evil in the wake of action stars like Jason Statham, Sylvester Stallone, and everyone else who may have been considered for a part in The Expendables.

Despite Hot Shots! Part Deux and Charlie Sheen's claim to the contrary, there is an undisputed number one deadliest action star in the annals of Hollywood military history. That title goes to the Terminator: Arnold Schwarzenegger.

Who was also in the Expendables. Three times.

(Lionsgate)

Big Data is back to settle the debates about everything we love. Just like the time a statistical analysis settled who was the best general in history, another data enthusiast set out to determine who was the deadliest onscreen action star in cinema history.

Granted, this is before the Expendables 3 and the newest Rambo movie, but unless Rambo kills an entire Colombian drug cartel (which I admit, he might), the winner should still be pretty clear.

Randal Olson, a data scientist at Life Epigenetics, merges cutting edge epigenetics research with advanced machine learning methods to improve life expectancy predictions. He put data collected from MovieBodyCounts.com to put together data visualizations for the deadliest action heroes. At the top, was the star of Predator, Total Recall, and my personal favorite, True Lies.

Thank you, sir.

As of Olson's 2013 writing, Arnold was at the top of the list with 369 kills. His highest single movie record came in Commando where in the final island scene alone, he managed to off 74 guys, mostly using firearms but featuring the best use of a toolshed. Hey, Alyssa Milano ain't gonna rescue herself.

Of the 200 actors listed in the data, the top ten include Chow Yun-Fat in second, Sylvester Stallone in third, and then Dolph Lundgren (thanks, Punisher!), Clint Eastwood, Nic Cage, Jet Li, Clive Owen, and Wesley Snipes. In fourth place comes Tomisaburo Wakayama, who got 150 of his 266 onscreen kills in a single movie, 1974's Lone Wolf and Cub: White Heaven in Hell.

The top 25 deadliest actors, visualized.

(Randal Olson)

Olson notes that the deadliest woman onscreen is Uma Thurman, who has 77 kills because remember: the Crazy 88s only had 40 members.

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