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Integrative Oncology Services Abramson Cancer Center

Posted: February 15, 2019 at 11:44 pm

At Penn Medicines Abramson Cancer Center, we are proud to offer integrative oncology services to supplement traditional cancer treatments such as chemotherapy, surgery and radiation therapy. The Abramson Cancer Centers wide range of integrative oncology options are designed to help you minimize or reduce side effects of cancer and cancer treatment, and promote your healing and recovery, and improve your overall sense of well-being.

For more information, read the Integrative Oncology frequently asked questions.

Services include:

Penns Integrative Oncology patient navigator connects patients and families to integrative services at Penn and in the community. She can help schedule an appointment or provide insight into the different therapies offered.

Laura Galindez, MSW, LSWIntegrative Oncology Patient Navigator215-360-0580 or laura.galindez@uphs.upenn.edu

Research being conducted at Penn Medicine tests the effects and mechanisms of promising health behaviors and integrative therapeutic approaches for symptom management and wellness promotion in cancer. Researchers at Penn are exploring ways to best incorporate integrative therapies safely and effectively into the conventional medical therapies to create patient-centered care for optimal health and healing.

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Integrative Oncology Services Abramson Cancer Center

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Testosterone Replacement Therapy for Health and Longevity

Posted: February 15, 2019 at 11:42 pm

A reader writes in regarding initiating TRT therapy.

From: Frank

Subject: Spoke with a TRT doctor

Date: Aug22, 2015 at 10:39:25 PM PDT

To: Jay Campbell

Jay thank you for your help with this, this is a BIG decision to do TRT for me. I need to do something.

Theres a TRT doctor (M.D.) at my gym and I shared my blood work with him today, here are his recommendations to make certain I can still have kids a safe script he says. He says I desperately need T.

1. Mixed Androgen / T Injection Weekly Test Cypionate 150mg, Nandrolone Decanoate 50mg, Winstrol 20mg, Deca 1.2mg

(you talk about T Cypionate in the book, but not about mixed injections)

2. Clomid 50mg before before bed

3. Anastrozole 1 cap every other morning

4. Propecia every morning.

5. HCG/Hydroxycobalamin 10 units (625mcg) injected nightly

6. Sermorelin GHRP 15 units combined with the HCG injection nightly.

This guy is an M.D. of internal medicine http://www.blahblah.com/about-us.html

Im still going to meet with the guys in Florida next week over Skype.

Am I on the right track?

Frank

Its unfortunate that these type of emails are not uncommon.

The answer to his question is:

ABSOLUTELY, POSITIVELY NOT!

What legitimate physician in their right mind would attempt to prescribe you medications (ie anabolic steroids) that are only allowed for wasting conditions? (and even then not usually justified)

There are none.

Gentleman, if your doctor or any doctor for that matter is recommending the usage of synthetics (and you do not have a clinical diagnosis which legally allows you to use these medications), RUN AWAY AS FAST AS POSSIBLE.

These type of rogue physicians are only going to get into serious trouble with the DEA/FDA and youre going to have to find another doctor.

There is only one way to prescribeTestosterone Replacement Therapy (for men who truly have Testosterone Deficiency Syndrome) and that is within the context of HEALTH and LONGEVITY.

End of story and case closed.

If you are struggling to find a competent doctor, familiarize yourself with our TRT resources page.

Listen to our Hangoutsand watch our videos. Check out my good friend Nelson Vergels Excel Male!

The answers to all of your questions are waiting for you to find them.

Be the BEST YOU EVER!

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Faculty Research – Department of Molecular Medicine …

Posted: February 14, 2019 at 3:43 pm

Rong Li, Ph.D.

Professor

Profile and Contact Information | Research | Laboratory

RESEARCH

Our laboratory addresses the following three fundamental questions concerning breast cancer treatment and prevention.

1. How does BRCA1 suppress tumor development in a gender- and tissue-specific manner? Women who carry cancer-predisposing germ-line mutations in BRCA1 have significantly increased chance of developing breast and ovarian cancers. While the BRCA1 activity in DNA repair is clearly important to the etiology of BRCA1-associated cancers, it is not clear whether the DNA repair function alone is sufficient to account for the gender- and tissue-specific tumor suppression by BRCA1. We previously identified a BRCA1-binding protein COBRA1, which is identical to the B subunit of NELF involved in pausing of RNA polymerase II. Using mouse genetics and clinical samples from BRCA1 mutation carriers, we are investigating whether a crosstalk between BRCA1 and COBRA1-regulated transcription machinery contributes to the tissue-specific function of BRCA1 in breast epithelium.

2. How can the antitumor activity of estrogen receptor (ER) be mobilized?In contrast to the tumor-promoting activity of ER, ER inhibits tumor growth in breast cancer. Because ER is present in a significant percentage of breast cancer cases, rallying its antitumor activity could serve as a potential therapeutic approach. Our pioneer discovery of a phosphotyrosine switch for the antitumor activity of ER enables us to mobilize ER function with unprecedented precision. We are testing the hypothesis that turning on this molecular switch of ER can inhibit triple negative breast cancer and circumvent hormonal resistance of ER-positive breast cancer, two clinically pressing areas where therapeutic potential of ER has been previously demonstrated.

3. How do adipose stromal cells (ASC) promote breast cancer progression?ASC is a major constituent of the breast and a source of tumor-promoting factors including estrogens. We recently discovered a new mechano-transducing pathway that links mechanical phenotype with the endocrine/paracrine output of ASCs. This pathway is initiated by a cell surface receptor called discoidin domain receptor 1 (DDR1). Combining three-dimension cell culture systems and animal models, we are exploring novel therapeutic approaches to disrupt this stroma-tumor communication.

Selected Publications

Complete list of published work.

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DNA Methylation | What is Epigenetics?

Posted: February 13, 2019 at 8:45 pm

Depiction of cytosines methylation and demethylation processes. The different modified forms of cytosine along with the corresponding enzymes responsible for each modification are shown.

DNA methylation is an epigenetic mechanism that occurs by the addition of a methyl (CH3) group to DNA, thereby oftenmodifying the function of the genes and affecting gene expression. The most widely characterized DNA methylation process is the covalent addition of the methyl groupat the 5-carbon of the cytosine ring resulting in 5-methylcytosine (5-mC), also informally known as the fifth base of DNA. These methyl groups project into the major groove of DNA and inhibit transcription.

In human DNA, 5-methylcytosine is found in approximately 1.5% of genomic DNA.In somatic cells, 5-mC occurs almost exclusively in the context of paired symmetrical methylation of a CpG site, in which a cytosine nucleotide is located next to a guanidine nucleotide. An exception to this is seen in embryonic stem (ES) cells, where a substantial amount of 5-mC is also observed in non-CpG contexts. In the bulk of genomic DNA, most CpG sites are heavily methylated while CpG islands (sites of CpG clusters) in germ-line tissues and located near promoters of normal somatic cells, remain unmethylated, thus allowing gene expression to occur. When a CpG island in the promoter region of a gene is methylated, expression of the gene is repressed (it is turned off).

The addition of methyl groups is controlled at several different levels in cells and is carried out by a family of enzymes called DNA methyltransferases (DNMTs). Three DNMTs (DNMT1, DNMT3a and DNMT3b) are required for establishment and maintenance of DNA methylation patterns. Two additional enzymes (DNMT2 and DNMT3L) may also have more specialized but related functions. DNMT1 appears to be responsible for the maintenance of established patterns of DNA methylation, while DNMT3a and 3b seem to mediate establishment of new or de novo DNA methylation patterns. Diseased cells such as cancer cells may be different in that DNMT1 alone is not responsible for maintaining normal gene hypermethylation (an increase in global DNA methylation) and both DNMTs 1 and 3b may cooperate for this function.

DNA demethylation is the removal of a methyl group from DNA. This mechanism is equally as important and coupled with DNA methylation. The demethylation process is necessary for epigenetic reprogramming of genes and is also directly involved in many important disease mechanisms such as tumor progression. Demethylation of DNA can either be passive or active, or a combination of both. Passive DNA demethylation usually takes place on newly synthesized DNA strands via DNMT1 during replication rounds. Active DNA demethylation mainly occurs by the removal of 5-methylcytosine via the sequential modification of cytosine bases that have been converted by TET enzyme-mediated oxidation. The ten-eleven translocation (TET) family of 5-mC hydroxylases includes TET1, TET2 and TET3. These proteins may promote DNA demethylation by binding to CpG rich regions to prevent unwanted DNA methyltransferase activity, and by converting 5-mC to 5-hmC, 5-hmC to 5-fC (5-formylcytosine), and 5-fC to 5-caC (5-carboxylcytosine) through hydroxylase activity. The TET proteins have been shown to function in transcriptional activation and repression (TET1), tumor suppression (TET2), and DNA methylation reprogramming processes (TET3).

The biological importance of 5-mC as a major epigenetic modification in phenotype and gene expression has been widely recognized. For example DNA hypomethylation, the decrease in global DNA methylation, is likely caused by methyl-deficiency due to a variety of environmental influences and has been proposed as a molecular marker in multiple biological processes such as cancer. The quantification of 5-mC content or global methylation in diseased or environmentally impacted cells could provide useful information for detection and analysis of disease. Furthermore, the detection of the DNA demethylation intermediate 5-fC in various tissues and cells may also be used as a marker to indicate active DNA demethylation. 5-fC can also be directly excised by thymine DNA glycosylase (TDG) to allow subsequent base excision repair (BER) processing which converts modified cytosine back to its unmodified state.

Differentially methylated regions (DMRs) are areas of DNA that have significantly different methylation status between multiple samples. Researchers will often perform genome-wide methylation profiling to identify DMRs between treated or untreated samples, revealing functional regions that may be involved in gene transcriptional regulation. There can be DMRs specific to tissues, cells, individuals, and so on. Differentially methylated regions may also be used as biomarkers or potential targets of epigenetic therapy.

Continue to the next page to learn about DNA methylation tools of the trade.

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Antibody could increase cure rate for blood, immune …

Posted: February 12, 2019 at 9:47 am

An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at the Stanford University School of Medicine.

The researchers believe the treatment could circumvent the need to use harsh, potentially life-threatening chemotherapy or radiation to prepare people for transplant, vastly expanding the number of people who could benefit from the procedure.

There are many blood and immune disorders that could be cured by a transplant of healthy stem cells, said Judith Shizuru, MD, PhD, professor of medicine at Stanford. But the pre-treatments necessary to get the healthy cells to transplant effectively are so toxic that we cant offer this option to many patients. A treatment that specifically targets only blood-forming stem cells would allow us to potentially cure people with diseases as varied as sickle cell disease, thalassemia, autoimmune disorders and other blood disorders.

Shizuru is the senior author of the study, which will be published online Feb. 11 inBlood. Postdoctoral scholar Wendy Pang, MD, PhD, and assistant professor of pediatrics Agnieszka Czechowicz, MD, PhD, share lead authorship of the work.

The study is one of two recently co-authored by Shizuru, Czechowicz and research associate Hye-Sook Kwon, PhD, indicating that an antibody targeting a protein called CD117 on the surface of blood-forming, or hematopoietic, stem cells can efficiently and safely eliminate the cells in mice and non-human primates. CD117 is a protein found on the surface of the stem cells. It regulates their growth and activity; the antibody, called SR1, binds to the protein and prevents its function.

The use of antibodies against CD117 to eliminate blood-forming stem cells is based on studies conducted in the laboratory of study co-author Irving Weissman, MD, director of Stanfords Institute for Stem Cell Biology and Regenerative Medicine and of the Ludwig Center for Cancer Stem Cell Research and Medicine at Stanford, and by then-graduate student Czechowicz.

The results of these studies, including a recently published article inBloodco-authored by Kwon that showed the antibody treatment was safe in non-human primates, set the stage for a clinical trial of the antibody at Stanford and the University of California-San Francisco in children with an immune disorder called severe combined immunodeficiency.

Hematopoietic stem cells are found in the bone marrow. They give rise to all the cells of the blood and immune system. Blood cancers, such as leukemia, arise when the stem cells or their progeny begin dividing uncontrollably; other genetic conditions such as sickle cell anemia or thalassemia occur when the hematopoietic stem cells generate malformed red blood cells or hemoglobin.

Often the best chance for a cure for these and other diseases originating in the bone marrow is to eliminate the patients own defective hematopoietic stem cells and replace them with healthy stem cells from a closely matched donor. But in order to do so, the patient must be able to withstand the pre-treatment, known as conditioning. Most conditioning regimens consist of a combination of chemotherapy and radiation in doses high enough to kill stem cells in the marrow.

Shizuru and her colleagues studied a mouse model of a class of human diseases called myelodysplastic syndromes, or MDS. People with MDS are unable to make mature, properly functioning blood cells and the only cure is a stem cell transplant. The disease primarily affects older adults, who are more likely than younger people to have additional, complicating medical factors and who are less likely to withstand the conditioning regimen.

Many of these people are elderly and unable to qualify for a transplant, Pang said. But there is no other cure for MDS.

Because there are many different types of MDS, the patients are assigned risk levels based on disease type, blood test results and the presence or absence of specific mutations in the affected cells. According to the World Health Organization, patients with low-risk MDS have a median survival rate of 5.5 years; those with high-risk disease have a median survival of 2.2 years.

SR1, the anti-CD117 antibody Pang and Czechowicz studied, recognizes CD117 on the surface of hematopoietic stem cells isolated from either healthy donors or from patients with MDS. They found that the antibody blocked the growth of both healthy and diseased stem cells in a laboratory setting. Then, the researchers investigated the effect of SR1 treatment on mice that were engineered to have a hybrid blood systems consisting of both human and mouse hematopoietic stem cells.

They found in the mice that SR1 quickly and efficiently eliminated both healthy human hematopoietic stem cells and cells isolated from low-risk MDS patients. In those animals with diseased human stem cells, SR1 pre-treatment significantly improved the ability of healthy hematopoietic stem cells to engraft after transplantation.

SR1 directly targets the disease-initiating cells for elimination in the mice, even though these cells typically have a significant competitive advantage, Pang said. This is the first antibody directed against CD117 that has been proven to clear both normal and diseased human cells from the recipient. We are very pleased with the results.

Although SR1 is also able to significantly reduce the number of high-risk MDS cells from the mice, the researchers found that the effect was transient: The diseased cells eventually returned even after transplant. In such cases, it may be necessary to combine anti-CD117 treatment with other therapies to completely eliminate the diseased cells, the researchers believe.

Based on the results of this study and others, we have received approval from the Food and Drug Administration to move forward with a clinical trial for MDS patients using a version of SR1 appropriate for a trial in humans, Shizuru said. We are very hopeful that this body of research is going to have a positive impact on patients by allowing better depletion of diseased cells and engraftment of healthy cells.

The work is an example of Stanford Medicines focus on precision health, the goal of which is to anticipate and prevent disease in the healthy and precisely diagnose and treat disease in the ill.

Jessica Poyser, a life science research professional at Stanford and researchers from Memorial Sloan-Kettering Cancer Center, UCSF and the New York University School of Medicine are also co-authors of the study.

Shizuru is a member of the Stanford Institute for Stem Cell and Regenerative Medicine and the Stanford Cancer Institute.

The research was supported by the National Institutes of Health (grants R01CA86065 and R01HL058770), the California Institute for Regenerative Medicine, the Virginia and D.K. Ludwig Fund for Cancer Research,the Gunn/Oliver Research Fund, the HL Snyder Medical Foundation, the Stinehart-Reed Foundation, the Walter V. and Idun Berry Foundation, the Howard Hughes Medical Institute, the Stanford Medical Scholars Research Program and the Paul and Daisy Soros Fellowship for New Americans.

Weissman and Czechowicz are inventors on patents that include the use of anti-CD117 antibodies in hematopoietic stem cell transplant conditioning, and Weissman and Shizuru are inventors on patents that pair anti-CD47 agents and anti-CD117 antibodies for the transplant conditioning. Weissman is a co-founder, stockholder and director of Forty Seven Inc., which has licensed these patents from Stanford University. Shizuru has equity ownership in Forty Seven Inc., and Czechowicz has equity ownership in Forty Seven Inc., Magenta Therapeutics, Beam Therapeutics, Editas Medicines and Global Blood Therapeutics.

Stanfords Department of Medicine also supported the work.

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Stem Cell Lafayette Louisiana 70503

Posted: February 12, 2019 at 9:46 am

Stem cell treatment has become a popular dispute in the international medical scene. This highly controversial treatment has actually gotten combined opinions from various stakeholders in the health care industry and has actually also drawn in the interest of political leaders, spiritual leaders and the general population at large. Stem cell therapy is considered a revolutionary treatment for individuals experiencing a wide variety of degenerative conditions. Some typical questions regarding this treatment are addressed below.

Are you a stem cell therapy provider in Lafayette LA 70503? Contact us for more information about joining our website.

Stem cells can be described as blank state or non-specialized cells that have the capability to become customized cells in the body such as bone, muscle, nerve or organ cells. This implies that these special cells can be used to regenerate or establish a wide variety of broken cells and tissues in the body. Stem cell therapy is for that reason a treatment that focuses on achieving tissue regrowth and can be used to treat health conditions and diseases such as osteoarthritis, degenerative disc illness, spinal cord injury, muscular degeneration, motor neuron disease, ALS, Parkinsons, heart disease and a lot more.

Being a treatment that is still under studio, stem cell therapy has actually not been completely accepted as a viable treatment alternative for the above discussed health conditions and health problems. A lot of research is currently being carried out by scientists and medical specialists in various parts of the world to make this treatment sensible and efficient. There are however numerous limitations imposed by governments on research involving embryonic stem cells.

Presently, there havent been numerous case studies performed for this kind of treatment. However, with the few case studies that have been carried out, among the significant issues that has actually been raised is the increase in a clients threat of establishing cancer. Cancer is brought on by the rapid multiplication of cells that tend not to die so easily. Stem cells have actually been connected with similar development factors that may lead to development of growths and other cancerous cells in patients.

Contact us for more information about stem cell doctor in Lafayette LA 70503

Stem cells can be extracted from a young embryo after conception. These stem cells are frequently described as embryonic stem cells. After the stem cells are drawn out from the embryo, the embryo is terminated. This is basically one of the significant causes of debate in the field of stem cell research. Many individuals argue that termination of an embryo is unethical and unacceptable.

Stem cells can still be gotten through other means as they can be discovered in the blood, bone marrow and umbilical cables of adult humans. Regular body cells can also be reverse-engineered to become stem cells that have limited capabilities.

New research has nevertheless revealed pledge as scientists target at developing stem cells that do not form into growths in later treatment stages. These stem cells can therefore efficiently change into other types of specialized cells. This therapy is for that reason worth investigating into as many patients can gain from this advanced treatment.

Find a stem cell provider close to Lafayette LA 70503

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Main address:Lafayette, Louisiana, 70503

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Helping You Decide | Louisiana Cord Blood Banking

Posted: February 12, 2019 at 9:46 am

The wheres, whats and hows When you are having a baby, there are dozens of decisions to make. One of the most important things you will have to decide is whether to bank your babys cord blood. In order to make the decision, which is best for you and your family, it is essential to Continue Reading

The research If you are expecting a baby then no doubt youve heard the phrase cord blood banking quite often. Parents today are bombarded with choices practically from the moment of conception, most of which pertain to the babys birth and immediate care following. Cord blood banking is no exception and you may have several Continue Reading

Typical costs associated with cord blood banking and storage Most expectant couples want to do everything possible to protect the health of their newborn child. New developments in medicine have made it possible to use the stem cells found in a babys umbilical cord to develop new treatments to fight diseases like leukemia. The babys Continue Reading

Your babys own stem cells from the normally discarded umbilical cord Most pregnant women and expectant parents have heard about cord blood banking and its ability to store cord blood stem cells for later use. For those of you who havent, cord blood banking uses the latest in technology to extract and preserve all the Continue Reading

The options for cord blood banking in Louisiana are as good if not better than many states

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Stem Cell Houma Louisiana 70363

Posted: February 12, 2019 at 9:46 am

Stem cell therapy has ended up being a popular debate in the worldwide medical scene. This extremely questionable treatment has actually gotten blended opinions from numerous stakeholders in the healthcare industry and has also brought in the interest of political leaders, religious leaders and the basic population at large. Stem cell treatment is thought about an innovative treatment for people dealing with a wide variety of degenerative conditions. Some typical concerns concerning this treatment are responded to below.

Are you a stem cell therapy doctor near Houma LA 70363? Contact us for more information about joining our website.

Stem cells can be described as blank state or non-specialized cells that have the ability to become customized cells in the body such as bone, muscle, nerve or organ cells. This indicates that these special cells can be used to regrow or develop a wide range of damaged cells and tissues in the body. Stem cell therapy is therefore a treatment that aims at accomplishing tissue regeneration and can be used to cure health conditions and illnesses such as osteoarthritis, degenerative disc illness, spine injury, muscular degeneration, motor neuron disease, ALS, Parkinsons, heart disease and a lot more.

Being a treatment that is still under studio, stem cell therapy has not been fully accepted as a feasible treatment alternative for the above discussed health conditions and diseases. A great deal of studio is presently being performed by scientists and medical professionals in different parts of the world to make this treatment feasible and effective. There are nevertheless different restrictions imposed by governments on research involving embryonic stem cells.

Presently, there have not been numerous case studies carried out for this form of treatment. However, with the few case studies that have actually been performed, among the significant concerns that has actually been raised is the increase in a clients threat of establishing cancer. Cancer is caused by the quick reproduction of cells that have a tendency not to pass away so easily. Stem cells have actually been associated with comparable growth elements that may result in formation of tumors and other cancerous cells in patients.

Contact us for more information about stem cell doctor in Houma LA 70363

Stem cells can be extracted from a young embryo after conception. These stem cells are commonly described as embryonic stem cells. After the stem cells are extracted from the embryo, the embryo is ended. This is essentially among the major reasons for debate in the field of stem cell research. Many individuals argue that termination of an embryo is unethical and undesirable.

Stem cells can still be obtained through other ways as they can be discovered in the blood, bone marrow and umbilical cables of adult human beings. Normal body cells can likewise be reverse-engineered to become stem cells that have limited capabilities.

New studio has nevertheless shown pledge as researchers focus on developing stem cells that do not form into tumors in later treatment phases. These stem cells can for that reason effectively transform into other kinds of specialized cells. This therapy is for that reason worth investigating into as lots of clients can take advantage of this innovative treatment.

Need a stem cell doctor in Houma LA 70363

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Human Genetics and Embryology – Open Access Journals

Posted: February 11, 2019 at 5:48 pm

Genetics is a discipline of the Biological sciences that studies personal traits the human or living organism inherit from its ancestors through genes and Embryology studies the development of the fertilized embryo from the ovum to the fetus stage.

Journal of Human Genetics and Embryology is a peer reviewed scientific journal known for rapid dissemination of high-quality research. This Human Genetics Journal with high impact factor offers an open access platform to the authors in academia and industry to publish their novel research in the mode of original articles, review articles, case reports, short communications, etc. It serves the International Scientific Community with its standard research publications.

This scholarly publishing is using Editorial Manager System for quality in the review process. Editorial Manager is an online manuscript submission, review and tracking system. Review process is performed by the editorial board members of Human Genetics & Embryology journal or outside experts; at least two independent reviewers approval followed by the editor is required for the acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

Human genetics is the study of inheritance in human beings. Human characteristics are inherited from parents to offspring in discrete unites called genes. Genes consist of specific information coded in the chromosome that consists of segments of chromosomes. Human genetics includes a variety of overlapping fields like classical, molecular, biochemical, population, developmental, clinical and cytogenetics.

Related Journals of Human Genetics

Human Genetics and Embryology,Journal of Cytology & Histology,Hereditary Genetics: Current Research,General Medicine: Open Access,Journal of Molecular and Genetic Medicine,Immunogenetics: Open Access, American Journal of Human Genetics, Annals of Human Genetics, Annual Review of Genomics and Human Genetics, Current Protocols in Human Genetics, European Journal of Human Genetics, Human Genetics, Twin Research and Human Genetics, International Journal of Human Genetics, Journal of Human Genetics

Genome biology deals with genomes. Genomes are the genetic material of an organism. They consists of DNA or RNA. Genome includes both the genes and as well as non-coding sequences of DNA or RNA.

Related Journals of Genome Biology

Human Genetics and Embryology,Cellular and Molecular Biology,Transcriptomics: Open Access,Journal of Probiotics & Health,Advancements in Genetic Engineering,Journal of Next Generation Sequencing & Applications,Genome Biology, Genome Biology and Evolution, Advances in Genome Biology, Egyptian Journal of Medical Human Genetics, Annals of Human Genetics

Mendelian genetics are the set of theories proposed by Gregor Johann Mendel. Mendelian genetics tends to explain inheritance and biological diversity regarding the transmission of genetic characters from parents to offsprings. These are based on statistical analysis and scientific breeding experiments on pea plants. Mendelian genetics is used to study the pattern of segregation of phenotypes under the control of genes taken one at a time.

Related Journals of Mendelian GeneticsHuman Genetics and Embryology,Journal of medical Microbiology and Medicine, Journal of phylogenetics and Evolutionary Biology, Journal of Molecular and Genetic Medicine,Trends in Genetics, Tree Genetics and Genomes, Topics in Current Genetics-TAG, Theoretical and applied genetics,Theoretische and angewandte Genetik, Statistical Applications in Genetics and Molecular Biology, Russian Journal of Genetics

Genetic linkagesis the tendency of alleles that are located close together on a chromosome to be inherited together during meiosis. Genes whose loci are nearer to each other are less likely to be separated onto different chromatids during chromosomal crossover, and are therefore said to be genetically linked. In other words, the nearer two genes are on a chromosome, the lower is the chance of a swap occurring between them, and the more likely they are to be inherited together.

Related Journals of Genetic Linkage Human Genetics and Embryology,Cellular and Molecular Biology, Herediatry Genetics: Current Research,Journal of Molecular and Genetic Medicine,Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Molecular Medicine, Genetics Selection Evolution, Chromosoma, Journal of Medical Genetics, Evolution-international journal of organic evolution, PLoS Genetics

Genetic code helps in carrying the information of living cells by DNA and RNA molecules. The genetic code is the set of rules by which information encoded within genetic material (DNA or mRNA sequences) is translated into proteins by living cells. This help in determining the amino acid sequence used in the synthesis of an organism proteins. It is the basis of heredity. It is universal in all organisms.

Related Journals of Genetic CodeHuman Genetics and Embryology,Journal of Medical Microbiology and Diagnosis,Journal of Phylogenetics and Evolutionary Biology, Biology and Medicine, Genetics Selection Evolution, Genes Chromosomes and Cancer, Journal of Medical Genetics, Advances in Genetics, Nucleic Acids Research, Cell Stem Cell, Systematic Biology

Gene mapping is any method used for determining the location of gene and relative distances between genes on a chromosome. gene maps are used for linkage analysis. Relative positions of genes can be determined by inheritance patterns. locating and identifying genes in a genetic map is known as gene mapping or genetic mapping.

Related Journals of Genome Mapping Human Genetics and Embryology,Journal of Molecular and Genetic Medicine,Biology and Medicine,Cellular and Molecular Biology,Genome Mapping and Genomics in Animals, Human Brain Mapping, Mapping and Image Science, Genome Mapping and Genomics in Animals, American Journal of Human Genetics

Huntington disease is an inherited disease.Huntington disease causes the degeneration of nerve cells in brain. This leads to functional inabilities and psychiatric disorders. Huntington disease also affects muscle coordination. It is caused by an inherited defect in a single gene. Gene that causes Huntington disease is HIT gene. Symptoms of the disease can vary between individuals and affected members of the same family, but usually progress predictably.

Related Journals of Huntington Disease Human Genetics and Embryology,Journal of Medical Microbiology and Diagnosis,Journal of Phylogenetics and Evolutionary Biology, Biology and Medicine, American Journal of Medical Genetics - Seminars in Medical Genetics, American Journal of Medical Genetics, Part A, American Journal of Medical Genetics-Part B, Neuropsychiatric Genetics, American Journal of Medical Genetics, Neuropsychiatric Genetics, Annual Review of Genetics, BAG - Journal of Basic and Applied Genetics

Embryology is a branch of biology. Embryology is the state of embryo development from the fertilization of the ovum to the fetus stage. Embryology deals with the origin, growth and development of an embryo. cells which result after fertilisation is termed as an embryo. After eight weeks the developed embryo can be termed as fetus. there are different stages of embryonic development. the study of embryo is also known as embryology.

Related Journals of EmbryologyHuman Genetics and Embryology,Journal of Phylogenetic Evolutionary Biology,Biology and Medicine, Advances in Anatomy Embryology and Cell Biology, Romanian journal of morphology and embryology, Italian Journal of Anatomy and Embryology, Neuroembryology, International Journal of Embryology

Human fertilization is a union of egg and sperm resulting in a fertilized egg, also called as zygote. Fertilization takes place inside the fallopian tube. Embryogenesis starts with fertilization of egg cell. Embryogenesis forms and develop the embryo.

Related Journals of Human Fertilization and EmbryogenesisHuman Genetics and Embryology,Molecular Biology, Journal of Medicine Microbiology and Diagnosis, Cellular and Molecular Biology, Herediatry Genetics: Current Research, Journal of embryo transfer, Journal of In Vitro Fertilization and Embryo Transfer, Iraqi Journal of Embryos and Infertility Research, Zygote, Advances in Anatomy Embryology and Cell Biology

Correlative embryology is a branch of embryology. It is used to compare and contrasts embryos of different species. Correlative embryology is used to show how all animals are related. Many things are compared, whether or not the organism has a notochord or whether or not it has gill arches. All embryos pass from single cells to multi celled zygotes, clumps of cells called morulas and hallow balls of cells called blastula before they differentiate into organs and systems of body. Many components go into Comparative Embryology and about the developmental similarities between species can be taken from its study, which many conclusions can be drawn.

Related Journals of Comparative EmbryologyHuman Genetics and Embryology,Journal of Molecular and Genetic Medicine,Biology and Medicine,Journal of Medicine Mcrobiology and Diagnosis, International Journal of Embryology, Italian Journal of Anatomy and Embryology, Anatomical Record Part A, The Discoveries in Molecular Cellular and Evolutionary Biology, Animal Reproduction, Annual Review of Cell and Developmental Biology, Applied Immunohistochemistry and Molecular Morphology

Embryonic development takes 8weeks to the embryo to develop. human embryo development depends on stem cells. During embryonic development cells divide, migrate and specialize. Early development stages forms a group of cells called inner cell mass which are able to produce all tissues of the body. Later during gastrulation period, the three germ layers are formed and most cells become restricted in type of cells that they produce.

Related Journals of Embryonic DevelopmentHuman Genetics and Embryology,Cellular and Molecular Biology, Herediatry Genetics: Current Research,Biology and Medicine,Zoomorphology, TSW Development & Embryology, Tissue and Cell, Stem Cells and Development, Somatic Cell and Molecular Genetics, Sexual Development, Russian Journal of Developmental Biology

Morphogenesis is an embryological process of differentiation of cells, tissues and organs and the development of organ systems according to genetic blueprint of the organism and environmental conditions. Morphogenesis is the development of biology along with the control of growth and cellular differentiation.

Related Journals of MorphohenesisHuman Genetics and Embryology,Journal of Phylogenetics and Evolutiomnary Biology, Herediatry Genetics: Current Research, Journal of Molecular and Genetic Medicine, Biology and Medicine,Journal of Medical MIcrobiology and Diagnosis, Biology and Medicine, General Medine: Open Access, Journal of Molecular and Genetic Medicine, Journal of Morphology, Journal of Anatomy, Italian Journal of Anatomy and Embryology, Human Reproduction, Reproduction, Fertility and Development, Molecular Reproduction and Development,

Sex chromosomes are either a pair of chromosomes that determines whether an individual is male or female. Sex chromosomes are designated as X and Y. There are 23 pairs of sex chromosomes. The other 22 chromosome are called as autosomes. chromosome which differs from shape or function of other chromosome that determines the sex of child. If the sex chromosome is Xy then it is male child and if sex chromosome is XY then it is female child. sex chromosomes carry those genes that control development of reproductive organs and secondary sex characteristics.

Related Journals of Sex chromosomesHuman Genetics and Embryology,Journal of Medical Microbiology and Diagnosis, Journal of Phylogenetics and Evolutionary Biology, Genes Chromosomes and Cancer, Genes, Chromosomes and Cancer - Index Copernicus, European Journal of Human Genetics, Journal of Genomics

Journal of Human Genetics and Embryology is associated with our international conference " 5th International Conference and Exhibition on Cell & Gene Therapy during May 19-21, 2016 at San Antonio, USA. We are particularly interested in research area Human genetics, Genome Sequencing, Embryology, Human fertilization, Genetic Disorders, Embryonic Development, Genetic code, Fertilization, Comparative Embryology, genome biology.

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Human Genetics and Embryology - Open Access Journals

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Human behaviour genetics – Wikipedia

Posted: February 11, 2019 at 5:48 pm

Human behaviour genetics is a subfield of the field of behaviour genetics that studies the role of genetic and environmental influences on human behaviour. Classically, human behavioural geneticists have studied the inheritance of behavioural traits. The field was originally focused on testing whether genetic influences were important in human behavior (e.g., do genes influence human behavior). It has evolved to address more complex questions such as: how important are genetic and/or environmental influences on various human behavioral traits; to what extent do the same genetic and/or environmental influences impact the overlap between human behavioral traits; how do genetic and/or environmental influences on behavior change across development; and what environmental factors moderate the importance of genetic effects on human behavior (gene-environment interaction).[1] The field is interdisciplinary, and draws from genetics, psychology, and statistics. Most recently, the field has moved into the area of statistical genetics, with many behavioral geneticists also involved in efforts to identify the specific genes involved in human behavior, and to understand how the effects associated with these genes changes across time, and in conjunction with the environment.[2]

In 1869, Francis Galton published the first empirical work in human behavioural genetics, Hereditary Genius. Here, Galton intended to demonstrate that "a man's natural abilities are derived by inheritance, under exactly the same limitations as are the form and physical features of the whole organic world." Like most seminal work, he overstated his conclusions. His was a family study on the inheritance of giftedness and talent. Galton was aware that resemblance among familial relatives can be a function of both shared inheritance and shared environments. Contemporary human behavioural quantitative genetics studies special populations such as twins and adoptees.

The initial impetus behind this research was to demonstrate that there were indeed genetic influences on human behaviour. In psychology, this phase lasted for the first half of the 20th century largely because of the overwhelming influence of behaviourism in the field. Later behavioural genetic research focused on quantitative methods.

Behavioral geneticists study both psychiatric and mental disorders, such as schizophrenia, bipolar disorder, and alcoholism, as well as behavioral and social characteristics, such as personality and social attitudes.

Recent trends in behaviour genetics have indicated an additional focus toward researching the inheritance of human characteristics typically studied in developmental psychology. For instance, a major focus in developmental psychology has been to characterize the influence of parenting styles on children. However, in most studies, genes are a confounding variable. Because children share half of their alleles with each parent, any observed effects of parenting styles could be effects of having many of the same alleles as a parent (e.g. harsh aggressive parenting styles have been found to correlate with similar aggressive child characteristics: is it the parenting or the genes?). Thus, behaviour genetics research is currently undertaking to distinguish the effects of the family environment from the effects of genes. This branch of behaviour genetics research is becoming more closely associated with mainstream developmental psychology and the sub-field of developmental psychopathology as it shifts its focus to the heritability of such factors as emotional self-control, attachment, social functioning, aggressiveness, etc.

Several academic bodies exist to support behaviour genetic research, including the International Behavioural and Neural Genetics Society, Behavior Genetics Association, the International Society of Psychiatric Genetics, and the International Society for Twin Studies. Behaviour genetic work features prominently in several more general societies, for instance the International Behavioral Neuroscience Society.

Human behavioural geneticists use several designs to answer questions about the nature and mechanisms of genetic influences on behaviour. All of these designs are unified by being based around human relationships which disentangle genetic and environmental relatedness.

So, for instance, some researchers study adopted twins: the adoption study. In this case the adoption disentangles the genetic relatedness of the twins (either 50% or 100%) from their family environments. Likewise the classic twin study contrasts the differences between identical twins and fraternal twins within a family compared to differences observed between families. This core design can be extended: the so-called "extended twin study" which adds additional family members, increasing power and allowing new genetic and environmental relationships to be studied. Excellent examples of this model are the Virginia 20,000 and the QIMR twin studies.

Also possible are the "children of twins" design (holding maternal genetic contributions equal across children with paternal genetics and family environments) and the "virtual twins" design - unrelated children adopted into a family who are very close or identical in age to biological children or other adopted children in the family. While the classical twin study has been criticized they continue to be of high utility. There are several dozen major studies ongoing, in countries as diverse as the USA, UK, Germany, France, the Netherlands, and Australia, and the method is used widely in fields as diverse as dental caries, BMI, ageing, substance abuse, sexuality, cognitive abilities, personality, values, and a wide range of psychiatric disorders. This is broad utility is reflected in several thousands of peer-review papers, and several dedicated societies and journals (See Twin study).

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Human behaviour genetics - Wikipedia

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