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Dr. Burke Orthopedics: Stem Cell Therapy – Pearland, Texas

Posted: November 14, 2018 at 11:41 pm

How Do Stem Cells Work?

Treatments that harness the power of stem cells are known as regenerative medicine, stem cell therapy, or stem cell transplants. Dr. Burke performs autologous stem cell therapy. This type of regenerative medicine requires no donor or surgeries, therefore making it a beneficial treatment option for many patients. Autologous stem cell enhancement with Dr. Burke Orthopedics is a series of small injections to the area of pain or damaged tissue. Dr. Burke harvests the stem cells from another part of the patients body then transplants the new cells, resulting in the stem cells developing as new tissues and organs that strengthen the body.There are no limits to regenerative medicine. Orthopedic doctors are introducing new advantages and benefits of this medicine as technology advances. Dr. Burke recommends autologous stem cell therapy for many conditions such as arthritis, muscle loss, neuropathy, scarring, skin burns, sports injuries and more.

As a result of its many uses in orthopedics and sports medicine, stem cell therapy stands out among other treatments. This non-surgical treatment reduces pain and generates stronger cells. Autologous stem cell enhancement is one of Dr. Burkes top treatments because of the speedy recovery and natural healing that follows stem cell injections. Patients regain their flexibility, functionality and range of motion with the help of stem cell advancements from Dr. Burke Orthopedics. At any age, stem cell therapy is a beneficial treatment option because of its many benefits and minimal risk. After years of arthritis pain or a devastating sports injury, consider regenerative medicine to repair damaged tissues and cells. Small stem cell injections provide great benefits for patients who wish to regain their normal lifestyle and eliminate painful conditions. Contact Dr. Burke Orthopedics for your same-day appointment with stem cell therapy.

There are many studies showing how stem cells help speed up recovery time for those who are treated. However, results vary from patient to patient. Although the science behind stem cells and how they work is becoming increasingly well-known and trusted throughout the medical community, there is still no way to quantitatively represent how they will impact each individual since every patient is unique.

If you are certain that stem cell therapy is the right treatment for you based on a referral from a doctor or recommendation from another surgeon, the highly skilled surgeon Dr. Burke is a great choice for getting this procedure done.

With some of the most skilled and highly qualified surgeons in the industry, Dr. Bruke has one of the highest success rates. This in part is due to making sure patients we accept as candidates go through a candidacy checking process, therefore ensuring the highest possible chances of the procedure benefetting the pateint.

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Stem Cell Therapy | Houston Wellness Clinic

Posted: November 14, 2018 at 11:41 pm

Stem cells are the future of medicine enhancing personal health.

Stem cells go in the body where they are needed, and become what the body needs them to become. Our stem cells are from human umbilical cord(HUCT) which are undifferentiated cells with no HLA matching, and which are potent, robust and consistent.

Advantages of HUCT:

** For general purposes given intravenously in as little as 10 minutes (for joint problems given intra-articularly)

NOTE: Because HUCT stem cells are less mature, the bodys immune system is unable to recognize them as foreign and so they are not rejected.

(HUCT cells also proliferate or differentiate more efficiently than older cells such as those obtained from the bone marrow)

Administration of HUCT are regulated by the AATB, and approved by the FDA (The FDA regulates HUCT through oversight of tissue banks)

Guidelines: The stem cell can only be used for the homologous function of the cell.

If interested there are over 4,000 clinical trials being conducted worldwide: These can be accessed onwww.clinicaltrials.gov

Many patients benefit from one treatment although further therapies can be performed every 3-6 months since the stem cells reproduce every 28 hours for 65 generations for approximately 90 days.

Side effects are usually very infrequent with about 2% complaining of mild flu-like symptoms. The stem cells should also be given while no anti-inflammatories are administered. (inflammation may be necessary for stem cells to work)

Results are usually apparent in 4-6 weeks but this time period may be shorter or longer.

To request a complimentary Stem Cell consultation, reach us at:

anju@houstonwellnessclinic.com(Contact Anju for scheduling)713-808- 9058

Houston Wellness Clinic550 Post Oak Blvd, Ste 330 Houston, TX 77027doctor@houstonwellnessclinic.com

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Stem Cell Therapy | Florida Orthopaedic Institute

Posted: November 14, 2018 at 11:41 pm

By NameArmaghani, Sheyan J, M.D.Baker, Christopher E., M.D.Barna, Steven A., M.D.Beatty, Ellen , M.D.Bernasek, Thomas L., M.D.Clare, Michael P., M.D.Davison, Thomas M., M.D.Echols, Jr., Eddy L., M.D.Epting, Timothy C., D.O.Frankle, Mark A., M.D.Garcia, Michael J, M.D.Garlick, Grant G, M.D.Gasser, Seth I, M.D.Grayson, Christopher W, M.D.Gustke, Kenneth A, M.D.Herscovici, Jr., Dolfi , D.O.Hess, Alfred V., M.D.Infante, Jr., Anthony F, D.O.Jackson, Howard B, M.D.Lindbloom, Benjanmin J., M.D.Lyons, Steven T, M.D.Maxson, Benjamin J, D.O.Mighell, Mark A, M.D.Mir, Hassan R, M.D., M.B.A.Miranda, Michael A, D.O.Morse, Adam C, D.O.Nydick, Jason A, D.O.Palumbo, Brian T, M.D.Pappou, Ioannis P, M.D.Ramirez, Jr., John D., D.C.Reina, David A, D.C.Saatman, Donna A, M.D.Samad, Adil A, M.D.Sanders, Roy W., M.D.Sellman, Jeff E, M.D.Shah, Anjan R, M.D.Small, John M., M.D.Stone, Jeffrey D, M.D.Tresser, Steven J., M.D.Walling, Arthur K., M.D.Watson, David T., M.D.Weinstein, Marc A., M.D.Yi, Seung Jin, M.D.Zaffer, Syed M., M.D.

By SpecialtyAll SpecialtiesArthritis & Adult Reconstruction SurgeryChiropracticElbowFoot, Ankle & Lower LegGeneral OrthopaedicsHand & WristHip & ThighInterventional SpineKnee & LegMusculoskeletal OncologyOrthopaedic TraumaPrimary Care Sports MedicineRoboticsShoulderSpineSports Medicine

By LocationsAll LocationsBloomingdaleBrandonBrooksvilleCitrus ParkNorth Tampa - Temple TerraceNorthdalePalm HarborSouth TampaSun City CenterWesley Chapel

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Stem Cell Transplants – Connecticut Children’s Medical Center

Posted: November 14, 2018 at 9:41 am

ContentWhat Are Stem Cells?

As you probably remember from biology class, every living thing is made up of cells including the human body. Cells are microscopic, but they power our bodies in amazing ways. For example, white blood cells help fight germs. Beta cells produce insulin to control sugars in our bodies. Melanocytes give skin its color.

Most of the time, each cell has a specific job to do. One cell cant do what another cell can, just as a doctor isnt trained to design a bridge and an engineer cant do surgery. So cells work as a team, grouping together to make up our tissues and organs.

But one type of cell is different. Stem cellscan develop into cells with different skills. In that way, stem cells are like students who have the choice of studying to be either doctors or engineers. None of the bodys other cells can become new cells like this.

When you hear about stem cell transplants, they probably involve hematopoietic (pronounced: heh-mat-uh-poy-ET-ik) stem cells. These stem cells are produced in the bone marrow andform blood and immune system cells. Hematopoietic stem cells can become any of three different types of blood cells:

As well as being able to turn into different types of cells, stem cells can also replicate meaning they can create new stem cells to keep the body healthy.

Stem cell transplants help people with severe blood or immune system illnesses. Stem cell transplants can help some people with certain kinds of cancer. They may also help people with non-cancerous diseases, such as serious immune deficiency problems, autoimmune diseases (likelupus), or blood disorders (thalassemia or sickle cell disease, for example).

With cancer, the bodys cells grow in a way thats not normal. These abnormal cells then spread quickly throughout the body. With immune system diseases like lupus, the immune system goes haywire and may damage healthy cells in the body. To fix these problems, doctors destroy damaged or abnormal cells and replace them with transplanted stem cells. The stem cells then replicate and turn into healthy cells.

A stem cell transplant involves taking healthy stem cells and putting them into the bloodstream of someone who is sick. This is done through an intravenous (IV) line. Its similar to having a blood transfusion. Once the stem cells get inside the persons body, they go to work creating healthy new blood, bone marrow, and immune system cells.

Doctors get hematopoietic stem cells from one of three different places:

A person who provides the stem cells is called a donor. Donors dont have to be other people sometimes a patient can act as his or her own donor.

Heres what happens when people donate their own stem cells: Before getting treatments likechemotherapy or radiation, doctors remove the persons stem cells from either the blood or bone marrow. This is called harvesting the stem cells. The stem cells are then frozen.

After the person has had chemotherapy or radiation, the cells are thawed and put back inside the body. Doctors may transplant new stem cells more than once it all depends on what a patient needs. When a person donates his or her own cells, its called an autologous (pronounced: aw-TOL-uh-gus) transplant.

Heres what happens when stem cells come from a separate donor: Separate donors are often siblings. Sometimes, parents will keep a newborns umbilical cord blood for this purpose. But donors can also be other family members or even volunteers who arent related to a patient.

Before collecting stem cells, doctors do tests to be sure the cells are a good match. If the patient and donor blood and tissue types dont match, the patients body may reject the donors stem cells. When someone other than the patient donates stem cells, its called an allogeneic (pronounced: al-low-juh-NEE-ik) transplant.

A lot can happen when introducing new cells to the body. Even if a donor is a good match, the body may still occasionally reject the transplant. This means that the bodys own immune cells destroy the transplanted stem cellsbecause they sense they areforeign.

Other times, the newly transplanted donor cells start attacking the patients body. This condition is called graft-versus-host disease. It can be serious, but doctors are usually able to treat it with steroids and other medicines. If you are getting a stem cell transplant, your doctor will explain the different things that can happen.

Transplanting stem cells is a very complicated process. It might take several months to decide if a patient is a good candidate and find the best donor.

After finding a good donor, doctors collect the stem cells. This may involve collecting stem cells from the donors hip bone or taking blood from the donor, separating out the stem cells, and returning the blood to the donors body. Sometimes doctors get the stem cells from a special blood bank where umbilical cord blood is stored (called a cord blood bank).

The next step in the transplantation process is conditioning therapy. The medical team gives the patient high doses of chemotherapy and/or radiation to kill unhealthy cells (like cancer cells) that are causing a persons illness. Sometimes the patient gets other types of medicines that dont kill the cells, but that weaken the immune system instead.

Wiping out unhealthy cells or weakening the immune system might sound scary, but it can actually be helpful. Destroying bone marrow makes room for new stem cells to take hold. And a weak immune system isnt as likely to jump into high gear and attack the new cells. So theres less chance that the new cells will be rejected.

Now its time for the actual transplant. This is done through an infusion where the stem cells are put in the patients body through an IV line. After a stem cell infusion, the medical team watches the patient closely to make sure the new stem cells are settling into the bone marrow and beginning to make new blood cells (called engrafting). If another person donated the stem cells, doctors will watch for signs of rejection or graft-versus-host disease.

Engrafting takes an average of 2 weeks, but can be as quick as 1 week or as long as 6 weeks. The medical team gives the patient medicines to promote engrafting and prevent problems like rejection.

People who get stem cell transplants have a high risk of infection because the process affects the immune system. That makes it harder to fight bacteria and other germs that enter the body. People whose stem cell transplants come from donors have an even higher risk of infection because they need to take medicines to reduce the chance of rejection. These medicines can weaken the immune system.

Because of these risks, doctors wont release someone from the hospital until they are sure the transplant has been successful and the person is well enough to go home.

Getting out of hospital doesnt mean going back to normal life right away. Because of the risk of infection, it might be 3 months or more before someone whos had a stem cell transplant can go back to school, visit the mall, or go to a sporting event. Thats because even a simple infection like a common cold can be life threatening for people whose immune systems need time to recover. Anywhere someone might come into contact with germs will be off limits.

Because stem cell transplants involve long isolation periods, they can be stressful. Luckily, medical teams know how tough that can be, and they know how important it is to get emotional support. Your doctor, a hospital social worker, or child life specialist can give you advice on getting through this difficult time. Dont hesitate to ask for help.

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Stem Cell Therapy in New Jersey | National Stem Cell Centers

Posted: November 13, 2018 at 10:42 am

National Stem Cell Centers in New Jersey is affiliated with a skilled surgeon that offers stem cell therapy and stem cell treatment and procedures for a number of disorders including, but not limited to, joint knee pain, shoulder pain, hip pain and other joint pain; osteoporosis; arthritis; auto-immune disorders; neurological disorders; and other conditions.

He employs an adipose fat harvesting process that uses your own fat to extract stem cells at a registered lab without the use of enzymes or manipulation, expansion or multiplication of cells.

Dr. Doshi is a dual ivy-league and fellowship trained facial plastic and reconstructive surgeon who has been invited both nationally and internationally to lecture on various surgical topics, published numerous scientific articles and book chapters in his field. He serves as one of only a handful of selected physicians across the country to advise on cases in the field.

Dr. Doshi approaches surgery through the lens of a discerning eye aimed at achieving the desired result with minimal downtime. His approach involves utilizing the most advanced non-surgical and surgical techniques delivered with meticulous technical skill resulting in long lasting and truly meaningful results.

He was trained at prominent institutions including New York Presbyterian Hospital-Columbia and Cornell and Stony Brook School of Medicine and serves as Adjunct Faculty at the Emory University School of Medicine.

Dr. Doshi is a member of the American Medical Association, Alpha Omega Alpha Medical Honor Society, American Academy of Otolaryngology Head & Neck Surgery, American Academy of Facial Plastic and Reconstructive Surgery, and American Academy of Cosmetic Surgery with a full license to practice surgical medicine in New York and New Jersey.

To schedule a complimentary stem cell therapy consultation with Dr. Doshi, please call (908) 372-2299 to submit the Contact Form on this page.

This location serves all of New Jersey including Bergen County, Passaic County, Somerset County, Wayne County, Paramus, Passaic, Paterson, Northern New Jersey, Central New Jersey including Morristown, Parsippany, Dover, and Southern New Jersey including Princeton.

Phone: (908) 372-2299

Address:30 W Century Rd, Suite 220Paramus, NJ 07652

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Stem Cell Therapy Vermont – Cordblood Search Tools

Posted: November 13, 2018 at 10:40 am

Present and Future of Stem Cell Therapy in Vermont

Cord blood banking near Vermont is a significant and comparatively little-known means of getting stem cells to treat a broad range of ailments. This post looks at the possible gains and what it's, how it works. It's targeted at future parents who would like to find out more. Here is a post that is insightful into the current state of play and its possibility for the future.

Stem cell banking freezes the blood from the umbilical cords of your infant for possible future use against disorders grown by your family. This blood source can already successfully treats many serious medical conditions. It's really worth assessing the possible advantages if you live in the Vermont area.

bone marrow remains the most common source for gathering stem cells in Vermont to date. The downside to bone marrow transplants s that they can extremely invasive and complex and may even result in constant uncomfortableness for the donors. Embryos are also a solution for stem cells but tend to be a massively controversial issue in Vermont , which leaves umbilical cord blood stem cell therapy. Its the safest and least invasive form of stem cell therapy.

Extensive studies near Vermont have showed that stem cell therapy from umbilical cord blood stem cells has countless advantages over the genes of circulatory blood and marrow derived genes and bone marrow. Although currently bone marrow is ahead of umbilical cord blood for certain specific diseases and procedures, it is often agreed that favor is slowly weighing in more on the side of cord blood.

An example of blood stem cell therapy in the Vermont area would be the use of stem cells for conditions such as leukemia, lymphomas, immune deficiencies, sickle cell anemia and certain cancers, all of which have proven to be deadly. On the other hand, the use of ones own stem cells to help with certain ailments may not be advisable. When ones own stem cells are used to treat something such as leukemia, it wont be effective because the stem cells will completely take over and replace the afflicted cells that caused the disease in the first place. However, if the patient has a sibling that donated stem cells then they may be a good enough match to hopefully offset the disease. It seems almost certain that the stem cell therapy industry will continue to grow in Vermont.

The future looks bright for stem cell therapy by cord blood cells in Vermont, despite the minority status of transfusions in the world. It is strongly believed by scientists that ones own individual cord blood will or could at some point be beneficial in the successful treatments of cancer. The reason behind this is because most adult-style cancers arent solely derived from genetics, whereas pediatric cancers are.

Researchers around Vermont are also discovering ways to manipulate the gene that is leukemia so that in the future it may be a possibility that your own blood could cure your cancer, thus making umbilical cord blood banking for future stem cell therapy even more valuable than it already is. There are even animal stem cell therapy experiments that are pushing the boundaries of conventional stem cell therapy and could ultimately mean that stem cells could cure spinal problems, strokes, heart failure and even diabetes.

The possibilities of stem cell therapy in Vermont are truly limitless just as all gene-related cures. Its even possible that neurological diseases and motor function disorders could tackled and cured with cord blood stem cell therapy. Other targeted possibilities on the list of stem cell therapy include Alzheimers and Parkinsons disease.

At this point in time public cord blood banks receive a small amount of umbilical cord blood for use in stem cell therapy and research. The reason for this is that many people are opting to store their umbilical cord blood privately which essentially insures their family against debilitating, deadly illnesses. Even though the amount of people storing cord blood for stem cell therapy, the more diseases that become treatable with stem cells, the amount of people that harvest theirs in Vermont will skyrocket.

Whether you decide to store umbilical cord blood publically or privately there is usually a limited amount of stem cells in a unit of stored umbilical cord blood, which means that the amount of cord blood available is only really effective for treating someone up to a certain age. Processes to increase the amount of stem cells in a single unit of cord blood are being tested with clinical trials near Vermont.

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Stem Cell Centers – Williston > Stem Cell Centers

Posted: November 13, 2018 at 10:40 am

Dr. Esti Bakty is a naturopathic physician with a special interest in pain management and naturopathic oncology. She has spent the past few years in clinical training with patients, educating and motivating them to participate more actively in their health. She combines a blended approach to supporting the mental and physical well-being of her patients.

Due to a severe car accident, Esti gained enthusiasm for minimizing her own pain with naturopathic medicine. She then went on to complete the four-year medical program at Southwest College of Naturopathic Medicine. During that time her mother was diagnosed with cancer. Under guidance of her mentor, she began treating her mother adjunctively with oncologists, which led to amazing results.

Since completing her formal education, she has enriched her approach to treatment through education including weight loss, chronic illness, fatigue, oncology, nutrition, arthritis, fibromyalgia, acupuncture, chronic pain, and general wellness. In addition, to her training in naturopathic primary care medicine, she has completed advanced training in sports medicine and natural pain management using the Hemwell-Hackett Prolotherapy technique (otherwise known as regenerative injection therapy).

Individualized care is at the cornerstone of her practice and patients receive truly specialized treatments with Dr. Bakty. Taking time to know and treat the whole person, rather than only symptoms, allows for care to be longer lasting and more effective. There is also an emphasis is put on education, so individuals and families can make lasting changes to their health and lives.

Dan Sweeney was born and raised in Vermont, between Chittenden and Addison county. He has traveled around New England, from Maine to upstate New York Opening Distributorships for nearly the last 10 years. Ultimately, he opened two locations of his own in Maine and New York.

Dan is no stranger to modern medicine, he has gone through more than 10 surgeries over the years, because of a motor vehicle accident. He identifies with the struggles of surgeries and medications that offer little or no benefit, but with high risks.

Dan now dedicates his time to Stem Cell Centers and helping patients with stem cell therapy.

I hate to see people going through the same struggles, with little to no hope of recovery.

My Brother was born with Leukemia in the 1980s. He had a bone marrow transplant, and by the age of 4 he was cured.

Brigit Frazier has been in the pharmaceutical business for the past 12 years. A few years ago, she received a personal training certification. During this time, Brigit made some healthy life changes, and was so excited to get the opportunity to work for a company that isn't all about medication.

In Brigits free time she is all about her children and grandchildren. When she is not with them, you can find her hiking or just spending time with nature and enjoying the beauty our planet has to offer. Living life to its fullest!

I LOVE the idea of taking stem cells from the human body and using them to help people with many physical ailments. I can't wait to see how this company changes lives!

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Recent Research on Stem Cells | Stem Cell Of America

Posted: November 10, 2018 at 6:42 pm

The following are recent research journals from US National Library of Medicine National Institutes of Health's pubmed.gov directory on the use of stem cells for various diseases and conditions:

Researchers said the treatment could be used for several conditions that include dementia.

By Stephen Feller | Oct. 15, 2015 at 4:30 PM

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons, characterized by progressive muscular atrophy and weakness which culminates in death within 2-5years...

J Clin Neurosci. 2013 Oct 19. pii: S0967-5868(13)00357-3. Author: Meamar R, Nasr-Esfahani MH, Mousavi SA, Basiri K.

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Alzheimer's disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD...

Neurodegener Dis. 2013 Oct 23. Author: Chang KA, Kim HJ, Joo Y, Ha S, Suh YH.

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Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal role in host defense against pathogens and acute stress...

Pharmacol Ther. 2013 Sep 27. pii: S0163-7258(13)00193-9. Author: Yao X, Huang J, Zhong H, Shen N, Faggioni R, Fung M, Yao Y.

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BACKGROUND AIMS: Pre-clinical evidence indicates that autologous bone marrow-derived mesenchymal stromal cell (BM-MSC) transplantation improves motor function in patients...

Cytotherapy. 2013 Oct 5. pii: S1465-3249(13)00561-6. Author: Wang X, Cheng H, Hua R, Yang J, Dai G, Zhang Z, Wang R, Qin C, An Y.

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Adult neural stem cells contribute to neurogenesis and plasticity of the brain which is essential for central regulation of systemic homeostasis. Damage to these homeostatic components...

Rev Endocr Metab Disord. 2013 Oct 25. Author:Purkayastha S, Cai D.

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Despite significant therapeutic advances, the prognosis of patients with heart failure (HF) remains poor, and current therapeutic approaches are palliative in the sense that they do not address the underlying problem...

Circ Res. 2013 Aug 30;113(6):810-34. Author: Sanganalmath SK, Bolli R.

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Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We propose that aberrant NET formation...

J Clin Invest. 2013 Jul 1;123(7):2981-93. Author: Knight JS, Zhao W, Luo W, Subramanian V, O'Dell AA, Yalavarthi S, Hodgin JB, Eitzman DT, Thompson PR, Kaplan MJ.

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Diabetic retinopathy (DR) is the leading cause of visual loss in the developed world in those of working age, and its prevalence is predicted to double by 2025. The management of diabetic...

Clin Med. 2013 Aug;13(4):353-7. Author: Williams MA, Chakravarthy U.

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Interleukin (IL)-10 is an important immunoregulatory cytokine shown to impact inflammatory processes as manifested in patients with multiple sclerosis (MS) and in its animal model, experimental autoimmune...

Brain Behav Immun. 2013 May;30:103-14. Author: Payne NL, Sun G, McDonald C, Moussa L, Emerson-Webber A, Loisel-Meyer S, Medin JA, Siatskas C, Bernard CC.

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Stem cell transplantation is being tested as a potential therapy for a number of diseases. Stem cells isolated directly from tissue specimens or generated via reprogramming of differentiated cells require...

Hum Gene Ther. 2013 Oct 23. Author: Rozkalne A, Adkin C, Meng J, Lapan A, Morgan J, Gussoni E.

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IMPORTANCE Recent advances in stem cell technologies have rekindled an interest in the use of cell replacement strategies for patients with Parkinson disease...

JAMA Neurol. 2013 Nov 11. Author: Kefalopoulou Z, Politis M, Piccini P, Mencacci N, Bhatia K, Jahanshahi M, Widner H, Rehncrona S, Brundin P, Bjrklund A, Lindvall O, Limousin P, Quinn N, Foltynie T.

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Since several years, adult/perinatal mesenchymal and neural crest stem cells have been widely used to help experimental animal to recover from spinal cord injury. More interestingly...

Stem Cells. 2013 Oct 23. Author: Neirinckx V, Cantinieaux D, Coste C, Rogister B, Franzen R, Wislet-Gendebien S.

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Even after decades of intensive studies, therapeutic options for patients with stroke are rather limited. Thrombolytic drugs effectively treat the very acute stage of stroke, and several neuroprotectants...

Cell Transplant. 2013 Oct 22. Author: Yoo J, Seo JJ, Eom JH, Hwang DY.

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Although we have supplied the links above to research journals, we are not saying that any of these studies would relate to your particular disease or condition. Please note, stem cells are not a substitute for proper medical diagnosis and care.

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What is Gene Therapy? – Learn.Genetics

Posted: November 9, 2018 at 10:42 am

Could the condition be corrected by adding one or a few functional genes?For you to even consider gene therapy, the answer must be "yes." For instance, genetic disorders caused by mutations in single genes tend to be good candidates for gene therapy, while diseases involving many genes and environmental factors tend to be poor candidates.

Do you know which genes are involved?If you plan to treat a genetic flaw, you need to know which gene(s) to pursue. You must also have a DNA copy of the gene available in your laboratory.

Do you understand the biology of the disorder?To design the best possible approach, you need to learn all you can about how the gene factors into the disorder. For example, which tissues the disorder affects, what role the protein encoded by the gene plays within the cells of that tissue, and exactly how mutations in the gene affect the protein's function.

Will adding a normal copy of the gene fix the problem in the affected tissue? Or could getting rid of the defective gene fix it?Sometimes when a gene is defective, no functional protein is being made from it. In cases like these, adding a functional copy of the gene could correct the problem. But sometimes a defective gene codes for a protein that starts doing something it shouldn't or prevents another protein from doing its job. In order to correct the problem, you would need to get rid of the misbehaving protein.

Can you deliver the gene to cells of the affected tissue?The answer will come from several pieces of information, including the tissue's accessibility and molecular signatures.

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Section of Molecular Medicine | Wake Forest School of Medicine

Posted: November 9, 2018 at 10:41 am

The Section of Molecular Medicine focuses on performing cutting-edge research in cellular and molecular mechanisms of human disease and supports graduate and postgraduate level educational programs within the Department of Internal Medicine.

A major goal of the section is to serve as a nidus for translational research by providing an environment where clinical and basic science faculty interact to make new discoveries and to educate future scientists.

The section consists of 24 primary faculty members and two emeritus faculty members who use cellular and molecular approaches to gain a better understanding of the basic mechanisms underlying acute and chronic human conditions, including sepsis, arthritis, atherosclerosis, diabetes, obesity, fatty liver, and cancer.

Molecular Medicine faculty collaborate on forward (disease/phenotype -> molecule) and reverse (molecule mutation/deletion -> disease phenotype) translational research to bidirectionally link new molecule discovery to disease pathogenesis using state-of-the-art omics (transcription, epigenetics, proteomics, metabolomics, lipidomics) and gene editing/deletion/overexpression technologies.

The Molecular Medicine Section is the academic home for the Molecular Medicine and Translational Science (MMTS) graduate program, one of the largest biomedical sciences graduate programs at Wake Forest University. MMTS offers PhD and MS training for BS, MD and DVM students. The section also provides laboratory research training and education in translational research for medical students, residents and postdoctoral fellows, including subspecialty fellows in the Department of Internal Medicine. A seminar series and journal club are held weekly as part of the training program in MMTS.

We invite you to explore our department and contact us with any questions you may have.

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