Regenerative medicine promotes the reparative response of diseased, dysfunctional or injured tissue using stem cells. Researchers prepare the stem cells in a lab beforehand, and are manipulated to specialize into specific types of cells, such as heart muscle cells, blood cells or nerve cells. While Stem cell therapy requires no invasive surgery, these stem cells called placental-derived mesenchymal stem cells (MSCs) are prepared beforehand, and injected directly into the area of pain or injury of your joint, muscle, ligament, or tendon. This procedures objective is simply to relieve pain, while the new stem cells stimulate your body to repair itself and heal faster, by generating healthy tissue. Stem cell therapy has recently had a major breakthrough within the medical field, particularly in the field of Orthopedics, due to the potential of these stem cells ability to allow the body to heal itself, and possibly eliminate arthritis pain and other chronic or acute pain from injuries. Benefits of Regenerative Medicine:

What is it? Platelet-rich plasma (PRP) therapy is a revolutionary procedure that uses components of the bodys own blood cells to stimulate the natural healing process in certain orthopedic conditions.The bodys first response to any soft tissue injury (ligaments and tendons) is to deliver platelet cells. Filled with healing and growth factors, the platelets jump-start the repair process. The platelets are separated from the rest of the blood cells and put through a process called centrifugation, which increases the platelets concentration. These platelets are then injected into the area needed with different concentrations of other cells to enhance the bodies healing process and decrease pain. This quick procedure can also provide effective pain relief, eliminating the need for surgery and prolonged recovery.

If you are a candidate for regenerative medicine or PRP therapy, call Midwest Orthopaedics in Shawnee Mission or Overland Park, Kansas at(913) 362-8317orrequest an appointment online.

Amniotic tissue has been used for many years to treat a variety of medical issues and has had excellent results. More recently there has been application to orthopedic issues such as arthritis and tendon/ligament healing. The amniotic membrane is a layer of the amniotic sac, which is donated after birth and does not contain fetal tissue. It is dehydrated and stored and then rehydrated at the time of injection. The process is very simple and similar to a cortisone injection. The injection can decrease inflammation and promote healing through multiple growth factors. It is safe and very effective.

Many orthopedic conditions can be treated with PRP or Amnitoic Membrane injections, including chronic pain and stiffness associated with osteoarthritis. If you have pain, limited mobility, swelling, or sports injuries, chances are regenerative medicine therapy can benefit you, and has shown promising results, treating these common conditions:

If you are a candidate for regenerative medicine therapy, call Midwest Orthopaedics in Shawnee Mission or Overland Park, Kansas at(913) 362-8317orrequest an appointment online.

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Regenerative Medicine | PRP Therapy | Midwest Orthopaedics

What regenerative medicine options do you offer?

DMOS offers three types of regenerative medicine options, all commonly used to treat different musculoskeletal conditions, including arthritis, muscle strains, tendon and ligament injuries.

The injection type differs based on the patient assessment and their individualized needs.

By definition, PRP is a collection of growth factors (which are proteins that are important in the healing of injuries), that can have controlled levels of white and red blood cells, based on the healing process necessary. Laboratory studies have shown that the increased concentration of growth factors in PRP can potentially speed up the healing process. Many world-class athletes use PRP therapy to repair their sports injuries faster.

Technically, BMAC is a collection of growth factors and cells, which include stem cells. Physicians use BMAC when they believe the potential upside of containing mesenchymal stem cells (MSCs) is necessary for treatment.

This injection serves to help as a local anti-inflammatory and reset the bodys natural balance in the arthritic joint. In technical terms, APS is a denatured PRP that delivers proteins, which block arthritic pain receptors. APS may be the preferred course of treatment based on if the patient exhibits radiographic evidence of knee, hip or shoulder OA (osteoarthritis).

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Regenerative Medicine - DMOS - Des Moines Orthopedic Centers

Regenerative injection therapy for tendons, ligaments, muscles and spine conditions.

About Regenerative Injection Therapies (RIT).

Regenerative injections broadly deals with the use of biologic materials to enhance the body's own repair mechanisms to help heal previously non-reparable tissues. The goal of these non-surgical procedures is to help heal the source of pain, not to simply mask it. The exact mechanism is evolving, but science points toward enhancing and stimulating healing and stabilizing factors of the local tissues.

Regenerative injection treatments offer a viable alternative for individuals considering elective orthopedic surgery or joint replacement due to arthritis or injury. Patients experience very little down time and they typically avoid the long, painful rehabilitation periods that can follow surgery. Since 2014, Regenerative Spine & Musculoskeletal Medicine has provided state of the art regenerative cellular therapies to help patients find relief from pain without invasive surgeries.

The Procedures:

Prolotherapy:

This treatment involves injecting a proliferant (usually dextrose) into weakened or injured joints, ligaments, or tendons. With a precise injection of a mild irritant solution directly on the site of injury, prolotherapy creates a mild, controlled inflammation that stimulates the bodys natural healing mechanism to lay down new tissue on the weakened area. Additional treatments repeat the process, allowing a gradual build-up of tissue to help restore strength to the area and relieve pain. Injection sessions are done 3-6 weeks apart, and usually a series of 3 injection sessions is done and then the response is assessed. The average number of treatment sessions is between 3 and 6.

Perineural Injections:

Peri-neural injections involves injecting diluted dextrose solutions superficially along the pathway of chronically inflamed nerves. They can be used for any part of the body where nerve pain exists. After the first treatment, pain relief may initially last for a period of four hours to four days. Repeated treatments (usually 6-8 sessions) are necessary, given every 1-3 weeks.

Platelet Rich Plasma Therapy (PRP):

During PRP therapy, a small vial of your own blood is drawn and placed in a centrifuge to separate the platelet-rich plasma from other blood components. This highly concentrated platelet-rich layer contains growth factors and a variety of cells. Growth factors stimulate local cells for tissue repair and remodeling. Your PRP is injected into and around the area of injury. Several injections may be done at the injured site at one time to fully treat the area. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Cell Therapy:

Stem cells(MSCs) are readily available and can be harvested from your bone marrow through a needle. Once injected into an area of injury, MSCs secrete bioactive molecules to modulate repair and offer the potential to regenerate injured cartilage, ligament, tendons, or muscle. MSCs can be thought of as the manager of your bodys innate healing potential. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Lipoaspirate (Fat) Graft:

Lipo aspirate therapy is a gentle process that uses your body's own fat tissue to cushion and support areas of injury or damage as your body heals itself. The fat is taken from the stomach, flank or thigh areas using a local anesthetic. It is especially effective for areas where there are soft tissue defects such as tears or arthritis. This type of injection is used in collaboration with PRP or bone marrow aspirate cell injections, which deliver growth factors to the injured area.

Alpha 2 Macroglobulin (A2M):

A2M is a naturally occurring molecule found in your blood that acts as a powerful protector against cartilage breakdown and progression of arthritis. A small vial of your own blood is drawn and placed in a centrifuge to separate the blood components, then is injected. A2M attaches to and removes the destructive enzymes that damage cartilage cells in the joint. The A2M is soothing to the joint and acts like a natural anti-inflammatory.

What parts of the body can benefit from regenerative treatments?

Spinal Injections:

Spinal procedures can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Epidural nerve blocks, spine ligaments, facet joint, sacroiliac joint and intervertebral disc injections with platelets/growth factors may be performed. The injection is performed in the same manner as conventional spine injections with the use of x-ray guidance to ensure accurate placement of the treatment.

Joint, tendon, ligament, muscle Injections:

Musculoskeletal injections can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Whenever appropriate the injection is performed with the use of x-ray or ultrasound guidance along with full safety and sterile precautions.

What conditions can benefit from regenerative injections?

Will insurance cover my Regenerative Injection?

Insurance companies will not pay for the cost of the Regenerative treatment. The cost of your injection can be discussed after your visit once you and the provider have decided on the most appropriate treatment option for you.

What sets Regenerative Spine & Musculoskeletal Medicine apart from others?

As the popularity of RIT grows, other medical professionals are beginning to perform these procedures, with great variation in training and background. Rene S. Melfi, M.D. is a physician specializing in non-surgical spine, orthopedic and musculoskeletal performance and function. With three national board certifications and Fellowship training in interventional spine and musculoskeletal medicine, Dr. Melfi has been performing spine and orthopedic injections since 2002. Dr. Melfi is also certified in Integrative Medicine and Acupuncture, and offers suggestions to enhance your results with recommendations for proper nutrition and supplements.

Your procedure at Regenerative Spine & Musculoskeletal Medicine is carefully chosen based on review of the latest evidence based medicine. Image guidance with x-ray or ultrasound is used, when appropriate, to confirm accurate placement of cellular therapy to optimize your results.

Call today for your appointment and a premier experience in Regenerative Injection therapy in Central New York 315-701-4000.

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Syracuse Regenerative Medicine - rsmmd.com

Merging Science with Technology to Treat Disease

Regenerative medicine uses clinical procedures to repair or replace damaged or diseased tissues and organs, versus some traditional therapies that just treat symptoms.

To realize the vast potential of tissue engineering and other techniques aimed at repairing damaged or diseased tissues and organs, the University of Pittsburgh School of Medicine and UPMCestablished the McGowan Institute for Regenerative Medicine. The McGowan Institute serves as a single base of operations for the Universitys leading scientists and clinical faculty working to develop tissue engineering, cellular therapies, and artificial and biohybrid organ devices.

The McGowan Institute is the most ambitious regenerative program in the nation, coupling biology, clinical science, and engineering. Success in our mission will impact patients lives, bring economic benefit, serve to train the next generation of researchers, and advance the expertise of our faculty in the basic sciences, engineering, and clinical sciences. Our efforts proudly build upon the pioneering achievements of the Thomas E. Starzl Transplantation Institute.

While there are certain select therapies based on regenerative medicine principles now in clinical use, much work lies ahead to realize the potential of this growing field. Advances in the underlying science, engineering strategies to harness this science, and successful commercial activities are all required to bring new therapies to patients.

The McGowan Institute sponsors a podcast series on regenerative medicine. Listen to some of the world's leading regenerative medicine researchers and physicians talk about their work.

Listen to the most recent podcasts.

Dr. Steven Little Receives International Young Investigator Award for Development of Novel Drug Delivery Systems

The Controlled Release Society has announced that McGowan Institute for Regenerative Medicine faculty member and University of Pittsburgh professor Steven Little, PhD, is the recipient of its 2018 Young Investigator Award. The honor annually recognizes one individual in the world, 40 years of age or younger, for outstanding contributions in the science of controlled release.

Learn more.

Dr. Stephen Badylak at the World Advanced Therapies & Regenerative Medicine Congress

Learn more.

From Technology Developed at the McGowan Institute, LyGenesis Closes $3 Million Series A Financing to Advance Its Organ Regeneration Technology to the Clinic

Learn more.

Living Donor Liver Transplant: A Lifesaving Option for All Patients with Liver Failure

Learn more.

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The McGowan Institute for Regenerative Medicine | UPMC

Regenerative medicine is a game-changer in the world of medicine. Treatments include: Stem Cell Therapy, PRP (Platelet Rich Plasma) Therapy and Amniotic Stem Cell Therapy (Amnion). Each custom treatment option may help to heal damaged tissues and organs, offering solutions and hope for people whose conditions have proven beyond repair previously.

I didnt know anything about PRP when I went to my appointment with Dr. Hall. I was able to do some research before I had anything done. The stem cells come from my own bone marrow. Stem cell treatment is fairly new, but shows positive results. I decided that it was something that could help me. I trust Dr. Hall. Dr. Hall removed the stem cells from my hip and injected them into my knees while I was in surgery under anesthesia.

I was in physical therapy after the surgery. Now Im back in the gym three days a week, exercising on the elliptical machine, weight training and in yoga classes. I walk five miles four or five days a week.

In six weeks, I was at 133 degrees range of motion, which was only 4 degrees behind my good leg. I attribute my advanced recovery to the outstanding hands of the DOC surgeon, the PRP/stem cell therapy, and Mike at ATI Physical Therapy.I attribute my advanced recovery to the outstanding hands of the DOC surgeon, the PRP/stem cell therapy, and Mike at ATI Physical Therapy.

If you are reading this testimonial and questioning whether the extra money spent on the PRP and stem cell therapy are worth it, I would highly recommend that you take out a loan if necessary in order to benefit from this healing therapy.

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Regenerative Medicine - directorthocare.com

Stem Cell Injections

The use of amniotic fluid and stem cells in medicine is much older and more widespread than people might think. It has been used to diagnose prenatal conditions for more than 70 years, and to treat injury, pain and scarring for nearly a century. What makes this therapy so exciting is the wealth of research and real-life application that supports its usefulness in not only relieving pain and assisting healing, but also in regenerating damaged soft tissues, including ligaments, tendons and cartilage. What this means to patients is the genuine possibility of healing injured tissues, making amniotic fluid/stem cell injection a revolutionary approach to managing, and even healing, ligament damage, tendonitis and osteoarthritis.

FMI utilizes NuCel bioactive amniotic suspension (HCT/P) to treat and repair soft tissue and to assist in certain types of orthopaedic surgery. NuCels more than 17,000 applications have proven it safe and effective at reducing pain, inflammation and scarring, and assisting in healing.

NuCel is derived from amniotic membranes from consenting donors, not from fetal tissue. NuCel contains concentrated multipotential stem cells, which are cells with the ability to make more of themselves, and growth factors, which are the naturally-occurring agents that can stimulate cell migration to injury sites to actively repair tissues. These agents are combined with all-natural hyaluronic acid and proteins to assist in delivery and support healing and healthy cell regeneration. NuCel is fully regulated by the FDA and has been used in thousands of patients without a single reported rejection, allergic response or other adverse reaction.

NuCel is not presently covered by insurance, which may cause some patients to be concerned about cost. But because NuCel has the potential to actually heal injuries and pain conditions, it can delay and even prevent the need for surgery, making it a preferred option for some patients.

FMIs Dr. Carl Ollivierre is not only a provider of NuCel, but also a patient who has successfully used it to treat his own posterior tibial tendinitis. Dr. Ollivierre provides NuCel injections at both FMI locations.

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Regenerative Medicine Florida Musculoskeletal Institute

Background

Regenerative medicine is an emerging area of science that holds great promise for treating and even curing a variety of injuries and diseases. Regenerative medicine includes using stem cells and other technologiessuch as engineered biomaterials and gene editingto repair or replace damaged cells, tissues, or organs. Stem cell-based approaches are under development in labs around the world, and some have already moved into clinical trials. Such progress notwithstanding, much work remains to be done toward the development of safe and effective regenerative medicine products and to realize the full potential of this field.

The 21st Century Cures Act, passed in December 2016, established the Regenerative Medicine Innovation Project (RMIP) to accelerate the field by supporting clinical research on adult stem cells while promoting the highest standards for carrying out scientific research and protecting patient safety. In recognition of the integral role of the Food and Drug Administration (FDA) in the successful development of this field, NIH is leading the RMIP in coordination with FDA.

The 21st Century Cures Act authorizes $30 million in federal awards over four years (20172020) for the RMIP. Importantly, the Act requires award recipients to match the federal funds provided with at least an equal amount of non-federal funds.This matching requirement will amplify the federal investment and could help stimulate collaboration and develop key partnerships across the public and private sectors.

Congress allocated $2 million for the RMIP in FY 2017. To make optimal use of these funds, researchers were invited to submit applications for competitive revisions to support clinical studies involving adult stem cells. Eight awards were issued in September 2017.

On December 6-7, 2017, the NIH and FDA hosted a public Regenerative Medicine Innovation Workshop that brought together key stakeholders to explore the state of regenerative medicine clinical research involving adult stem cells with a focus on approaches to the development of safe and effective products. Video recordings from each session are available. The deliberations at this workshop were instrumental in helping to identify some of the major needs, opportunities, and challenges in the regenerative medicine field.

Input from the workshop and other sources informed the development of the next round of funding opportunity announcements (FOAs) published in August 2018. These FOAs solicit new investigator-initiated projects, which may either involve a clinical trial or entail late stage Investigational New Drug (IND)- or Investigational Device Exemption (IDE)-enabling clinical research. Applicants who have questions about these opportunities may consult our Frequently Asked Questions, and those with additional questions are encouraged to either consult the relevant program officer listed in the FOA, or write to RMIP@nih.gov.

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RMI | National Institutes of Health (NIH)