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Gene Therapy | Voyager Therapeutics

Posted: October 11, 2018 at 2:47 am

The time is right for gene therapy.

Over the last decade, adeno-associated virus (AAV) has emerged as a highly promising and attractive approach to gene therapy. AAV is a common, naturally occurring virus that has been shown to be a well-toleratedand effective gene therapy delivery vehicle in clinical trials. Advances in AAV vector design and related dosing techniques that enable widespread gene delivery in the brain and spinal cord have made AAV particularly well-suited for the treatment of neurological diseases. Since the targeted cells in the central nervous system (CNS) are long-lived, non-dividing neurons, treatments delivered in a single dose could generate long-lasting, or even lifelong, benefits. More than eight years of durable expression has been seen in the human brain following treatment with an AAV vector.

Importantly, improvements in related technology and approaches have made AAV production more easily scalable and efficient to meet clinical and commercial requirements. Voyager diligently selects and optimizes AAV vectors that are best suited for each program. We continue to invest to advance the science and technology around the three key elements of AAV vectors: capsid, promoter and transgene. We also systematically develop and optimize delivery techniques that are best suited for a particular disease.

Members of our team have co-discovered many of the known naturally occurring AAV capsids, which are the outer viral protein shells that enclose the target gene or micro RNA cassette, and have also created promising genetically engineered AAV capsids. We have efforts underway to genetically engineer capsids to yield vectors with desirable properties, such as enhanced tissue specificity and improved delivery of genes to the brain and spinal cord.Efforts are also underway at Voyager to optimize novel AAV capsids that demonstrate enhanced blood-brain barrier penetration for the potential treatment of CNS diseases following systemic administration of the AAV gene therapy vector.

We then design the vector genome, or payload, that we intend to deliver as a therapeutic, as in the case of our Friedreichs ataxia program, or silence or knockdown, as in the case of our ALS and Huntingtons disease programs.

Identifying the optimal route of administration and delivery parameters, such as infusion volume, flow rate, vector concentration and dose and formulation for a specific disease are critical to achieving safe and effective levels of gene expression in the targeted region of the CNS. For Voyagers current pipeline programs, we are pursuing a surgical approach for direct injection into a targeted region of the brain, coupled with real-time MRI in the case of our advanced Parkinsons disease and Huntingtons disease programs, or injection into the cerebrospinal fluid for broader delivery to the cells within and surrounding the spinal cord for our ALS and Friedreichs ataxia programs.

Led by pioneers in AAV gene therapy and neuroscience, we are deeply committed to developing gene therapies for severe neurological diseases that have the potential to positively impact the lives of people living with these diseases. For more information about how we engage with patients and the advocacy community, please visit our patients and caregivers page.

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Gene-Therapy – Experimental Mesothelioma Treatment

Posted: October 11, 2018 at 2:47 am

All types of cancer cells appear to have at least one essential thing in common: They have faulty genes. At the center of every cell in our bodies, there is a nucleus containing thousands of genes made of DNA. Genes are coded instructions for making proteins, the molecules that control how cells work.

A cell with healthy DNA will perform its function in the body, create new cells as needed and destroy itself when it is damaged beyond repair. However, when a carcinogen such as asbestos damages the DNA in a cell, it may cause the cell to grow and divide out of control, leading to cancer.

Many researchers believe that just as faulty genes are the key to cancer formation, modified genes may be the key to cancer treatment. Mesothelioma researchers are hopeful that gene therapy will bring us closer to a cure for mesothelioma.

Gene therapy is a broad category that refers to several emerging treatment approaches involving the novel science of genetic modification. It wasnt until recently in 2017 that the U.S. Food and Drug Administration (FDA) approved a gene-therapy-based cancer treatment for the first time.

So far, most gene therapies tested for mesothelioma have shown either limited effectiveness or severe side effects and risks of complications. For this reason, all types of gene therapy for mesothelioma are experimental and only available through clinical trials.

The most obvious gene therapy approach is to fix the genetic fault that causes cells to become cancerous in the first place. To perform this medical feat, however, scientists have to overcome two major challenges.

First, researchers have not been able to pinpoint a specific gene that can stop the progression of mesothelioma in most patients. The likeliest candidates are natural tumor-suppressing genes that prevent genetic mutations or ensure mutant cells self-destruct before they grow into tumors. The p53 gene, the BAP1 gene and microRNA gene 16 have all been studied as genes that may be able to stop the progression of mesothelioma.

Second, inserting these tumor-suppressing genes requires a microscopic delivery vehicle, or vector, that can penetrate deep into a tumor. Genetically modified viruses and specially designed nanoparticles are both in development as gene therapy vectors.

Get help connecting with the nation's top mesothelioma doctors and cancer centers.

The same vectors that could carry tumor-suppressing genes could also insert artificial suicide genes into cancer cells.

If researchers can develop a vector that infects all the cells in a tumor while leaving the rest of the bodys cells alone, it would enable a special form of targeted chemotherapy called suicide gene therapy. The artificial suicide gene causes cancer cells to produce an enzyme that converts an otherwise harmless drug into a lethal toxin, so the drug kills cancer cells while leaving healthy cells unharmed.

Rather than trying to alter cellular DNA, some researchers instead focus on modifying deadly viruses to only kill cancer cells. This approach, known as virotherapy, was discovered by accident when doctors noticed many cancer patients who contract measles experience tumor regressions. Since then, scientists have been developing modified versions of the measles virus as an experimental treatment for several types of cancer, including mesothelioma.

In a 2016 trial of virotherapy for pleural mesothelioma patients, researchers were able to safely inject a special strain of the measles vaccine directly into the cancer site, potentially fighting the cancer through viral infection as well as provoking a natural immune system response against the cancer.

The most exciting recent development lies at the intersection of gene therapy and immunotherapy, another cutting-edge cancer treatment science. The first gene therapy for cancer approved by the FDA is known by the brand name Kymriah and generically referred to as CAR T-cell therapy. Kymriahs makers call it a living drug, because it is produced by extracting the patients own immune cells and reprogramming them to target cancer.

CAR T-cell therapy represents one of the first truly individualized and targeted cancer treatments, but it also has significant limitations: Kymriah is FDA-approved only for leukemia, it is extremely expensive, and it comes with the risk of severe side effects. Nevertheless, this technology has the potential to improve outcomes for mesothelioma patients in the future.

Last Modified September 25, 2018

Registered Nurse and Patient Advocate

Karen Selby joined Asbestos.com in 2009. She is a registered nurse with a background in oncology and thoracic surgery and was the director of a tissue bank before becoming a Patient Advocate at The Mesothelioma Center. Karen has assisted surgeons with thoracic surgeries such as lung resections, lung transplants, pneumonectomies, pleurectomies and wedge resections. She is also a member of the Academy of Oncology Nurse & Patient Navigators.

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Gene-Therapy - Experimental Mesothelioma Treatment

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Genomic Career: Molecular Geneticist ($35,620-$101,030)

Posted: October 10, 2018 at 5:45 am

OverviewDescription

Molecular geneticists identify genes associated with specific functions, diseases, and disorders. They identify genetic mutations on a molecular level and establish genotypes to better understand the nature of genetic makeup. Some molecular geneticists work to develop new diagnostic tests based on DNA analysis.

The most common activity undertaken by molecular geneticists is identifying the causes of congenital disease and determining what roles environmental conditions play in their development. Their hope is to devise ways to minimize or even eliminate the presence of these disorders in humans.

Molecular geneticists use cutting edge equipment and techniques to gather, replicate, and analyze DNA. After testing is complete, they produce reports summarizing their findings and share them with colleagues. By gathering enough information, geneticists can form new understandings and methods for addressing genetic diseases and disorders.

Given the abundance of information coming from the Human Genome Project, opportunities in the field of molecular genetics will continue to expand. As genetic testing becomes more commonplace, more molecular geneticists will be needed to conduct and evaluate tests and their results.

Molecular geneticists work in laboratories associated with hospitals, universities, and medical research centers. They typically work with a team of assistants and related specialists. Their work demands familiarity with sophisticated equipment and methods, about which they are expected to continue learning throughout their careers.

Molecular geneticists are most frequently employed by hospitals, though universities and government agencies are also common employers. There is limited employment by private corporations.

A typical Salary Range for this career is $35,620 - $101,030 annually.

The Median Income for this career is about $65,080 annually.

A Bachelor's degree is the minimum expected of molecular geneticists. The best opportunities are available to those who obtain at least a Ph.D. or M.D. One's Bachelor's and Master's degrees should be in genetics or molecular biology, complemented by courses in biochemistry, biomedical science, and biotechnology.

Experience is a key factor in job opportunities. Those with significant experience in laboratory settings will have a competitive edge.

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Molecular Genetics, Biochemistry & Microbiology

Posted: October 10, 2018 at 5:45 am

Faculty and Staff Search Select a member name TYPE IN NAMEAljohani, Hashim MusallamBeucler, Matthew Bridges, James Cartwright, Iain L.Casey, Anthony MichaelCastleberry, Mark AndrewChoi, Edmund MChristensen, Collin JordanCole, Brenda SColeman, Anna Walsworthcong, Xinyu Czepnik, Magdalena Davidson, Sean Deacon, Patrick Dean, Gary EDeepe, George SamuelFenker, Daniel Fischesser, Demetria MarieFreeman, MacKenzie ReneeGebelein, Brian Phd Gipson, Gregory Goebel, Erich JGruenstein, Eric IanHall, Daniel PHassett, Daniel JHerr, Andrew B.Hildeman, David Holokai, Loryn LeilaniHong, Christian Huang, Taosheng Hui, David YKappes, Emily ChristineKattamuri, Chandramohan Kolb, Ellen MarieKovall, Rhett A.Lawder, John JamesLerner, Grigoriy YevgenyevichLieberman, Michael ALingrel, Jerry BLuo, Fucheng Luo, Yu Manoharan, Palanikumar Martin, Kendall ElizabethMcCoy, Jason CMenon, Anil GMillay, Douglas Miller, William Miser, Jaimie LynnMolkentin, Jeffrey Monaco, John J.Moquin, Kelli Muglia, Louis Ozbudak, Ertugrul Panchanathan, Ravichandran Panmanee, Warunya Pradhan, Suman Puga, Alvaro Rance, Mark A.Rosevear, Paul R.Rosile, Sarah MarieRothenberg, Marc E.Sadayappan, Sakthivel Saelinger, Catharine BSawtell, Nancy Schoch, Emma CarolynShull, Gary EdwardSmall, Jason TSmith, Haley E.Spearman, Paul WStambrook, Peter JStottmann, Rolf Stringer, James RStuessel, Kory NicholasThompson, Richard LThompson, Thomas B.Vest, Katherine ElizabethWaxman, Joshua Way, Sing_Sing Webb, Jordan Weiss, Alison A.Wells, Susanne Whitlow, Thomas JWieczorek, David FWolfe, Erin AshleyWolfkiel, Patrick RWright, Zoe Yarawsky, Alexander EYuan, Zhenyu Yurick, Lawrence JamesZavros, Yana Zhang, Yu

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Molecular Genetics Jobs, Employment | Indeed.com

Posted: October 10, 2018 at 5:45 am

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GeneID Lab Advanced Molecular Diagnostics

Montvale, NJ

$35,000 a year

Veterans Affairs, Veterans Health Administration

New Orleans, LA

$103,395 - $264,000 a year

Medical Management Group

Harris County

SingulOmics Corporation

University of California, Davis

Cancer Genetics Inc

EGL Genetic Diagnostics LLC

Ann & Robert H. Lurie Childrens Hospital of Chica...

George Washington University

Battelle

University of Illinois at Chicago

Lighthouse Lab Services

Charleston, SC 29402

$15 an hour

Advanced Molecular Diagnostics

Montvale, NJ

$70,000 - $80,000 a year

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PPD is a leading global contract research organization providing drug development, lifecycle management and laboratory services

Research Assistant salaries in United States

$13.64 per hour

Indeed Salary Estimate

Please note that all salary figures are approximations based upon third party submissions to Indeed. These figures are given to the Indeed users for the purpose of generalized comparison only. Minimum wage may differ by jurisdiction and you should consult the employer for actual salary figures.

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Nanomedicine – Overview

Posted: October 8, 2018 at 2:45 pm

The program began in 2005 with a national network ofeight Nanomedicine Development Centers. Now, in the second half of this 10-year program, the four centers best positioned to effectively apply their findings to translational studies were selected to continue receiving support.

Nanomedicine, an offshoot of nanotechnology, refers to highly specific medical intervention at the molecular scale for curing disease or repairing damaged tissues, such as bone, muscle, or nerve. A nanometer is one-billionth of a meter, too small to be seen with a conventional lab microscope. It is at this size scale about 100 nanometers or less that biological molecules and structures operate in living cells.

The NIH vision for Nanomedicine is built upon the strengths of NIH funded researchers in probing and understanding the biological, biochemical and biophysical mechanisms of living tissues. Since the cellular machinery operates at the nanoscale, the primary goal of the program - characterizing the molecular components inside cells at a level of precision that leads to re-engineering intracellular complexes - is a monumental challenge.

The teams selected to carry out this initiative consist of researchers with deep knowledge of biology and physiology, physics, chemistry, math and computation, engineering, and clinical medicine. The choice and design of experimental approaches are directed by the need to solve clinical problems (e.g., treatment of sickle cell disease, blindness, cancer, and Huntingtons disease). These are very challenging problems, and great breakthroughs are needed to achieve the goals within the projected 10 year timeframe. The initiative was selected for the NIH Roadmap (now Common Fund) precisely because of the challenging, high risk goals, and the NIH team is working closely with the funded investigators to use the funds and the intellectual resources of the network of investigators to meet those challenges.

10 Year Program Design High Risk, High Reward

The Centers were funded with the expectation that the first half of the initiative would be more heavily focused on basic science with increased emphasis on application of this knowledge in the second five years. This was a novel, experimental approach to translational medicine that began by funding basic scientists interested in gaining a deep understanding of an intracellular nanoscale system and necessitated collaboration with clinicians from the outset in order to properly position work at the centers so that during the second half of the initiative, studies would be applied directly to medical applications. The program began witheight Nanomedicine Development Centers(NDCs), and four centers remain in the second half of the program.

Clinical Consulting Boards (CCBs)

The program has establishedClinical Consulting Boards (CCBs)for each of the continuing centers. These boards consist of at least three disease-specific clinician-scientists who are experts in the target disease(s). The intent is for CCBs to provide advice and insight into the needs and barriers regarding resource and personnel allocations as well as scientific advice as needed to help the centers reach their translational goals. Each CCB reports directly to the NIH project team.

Translational Path

In 2011, the PIs of the NDCs worked with their CCBs to precisely define their translational goals and the translational research path needed to reach those goals by the end of the initiative in 2015. To facilitate this, the NIH project team asked them to developcritical decision pointsalong their path. These critical decision points differ from distinct milestones because they may be adjusted based on successes, challenges, barriers, and progress. Similarly, the timing of these decision points may be revised as the centers progress. Research progress and critical decision points are revisited several times a year by the CCB and the NIH team, and when a decision point is reached, next steps are re-examined for relevance, feasibility and timing.

Transition plan

Throughout the program, various projects have been spun off of work at all the centers and most have received funding from other sources. This was by design as work at each center has been shifting from basic science to translational studies. Centers will not be supported by the common fund after 10 years. It is expected that work at the centers will be more appropriately funded by other sources. Pre-clinical targets will likely be developed, and the work at each center will be focused on a specific disease so the work will need to transition out of the experimental space of the common fund.

Support for the NIH Nanomedicine Initiative is provided by the NIH Common Fund, and a team of staff members from across the NIH oversees the program. You may direct questions or comments on the NIH Nanomedicine Initiative to Dr. Richard S. Fisher, Nanomedicine Project Team Leader (nano@nih.gov).

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Nanomedicine Conferences | Nanotechnology Events …

Posted: October 8, 2018 at 2:45 pm

About Conference

ME Conferences invites all the participants from all over the world to attendNanomedicine and Nanotechnology in Health CareDuring 17-19 September, 2018 at Abu Dhabi, UAE. This includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions. And it provides an opportunity to learn about the complexity of the Diseases, discuss interventional procedures, look at new and advances in Nanotechnology and their efficiency and efficacy in diagnosing and treating various diseases and also in Healthcare treatments.

ME Conferences organizes 1000+ Global Events Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open access journals which contains over 1,00,000 eminent personalities, reputed scientists as editorial board and organizing committee members. ME Conferences journals have over 5 million readers and the fame and success of the same can be attributed to the strong editorial board which contains over 30000 eminent personalities and the rapid, quality and quick review processing.ME Conferences make the perfect platform for global networking as it brings together renowned speakers and scientists across the globe to a most exciting and memorable scientific event filled with much enlightening interactive sessions, international workshops, world class international exhibitions and poster presentations.

Why to attend?

This Conference Nanomedicinemeet 2018 will focus on Healthcare and Medicine. World-renowned speakers, the most recent techniques, tactics, and the newest updates in fields Nanotechnology and Engineering, Medical Nanotechnology, Tissue Engineering are hallmarks of this conference. Nanomedicinemeet-2018 is an exciting opportunity to showcase the modern technology, the new products of your company, and/or the service your industry may offer to a broad international audience. It covers a lot of topics and it will be a nice platform to showcase their recent researches on Nanotechnology, MaterialScienceand other interesting topics.

Target Audience:

The termNano medicineencompasses a broad range of technologies and materials. Types of nanomaterials that have been investigated for use as drugs,, drug carriersor other Nonmedical agents. There has been steep growth in development of devices that integrate nanomaterials or other nanotechnology. Thenanotechnology-based medical devices market is categorized into three major segments, namely, therapeutic applications, diagnostics applications, and research applications. Rising incidence of lifestyle and age-related disorders (such as cardiovascular and hearing disorders) has contributed significantly to the growth of the nanotechnology-based active implantable devices market. Nanotechnology, or systems/device manufacture at the molecular level, is a multidisciplinary scientific field undergoing explosive development. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medicine, communications and genomics. On the surface, miniaturization provides cost effective and more rapidlyfunctioningbiological components. Less obvious though is the fact that Nanometer sized objects also possess remarkableself-ordering and assemblybehaviors under the control of forces quite different from macro objects.

Advances in technology have increased our ability to manipulate the world around us . Nanotechnology is rapidly emerging within the realm of medicine. Nanomedicine is the process of diagnosing, treating, and preventing disease andtraumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body. An exciting and promising area of Nano technological development is the building of Nanorobots. Highly precise positioning techniques are required in Miniaturing in chip technology, optics , micro mechanic, medicine , gene and biotechnology. The new manipulation technology is the desire to enter the micro and Nano world not only by viewing but also acting, alteringmicro andNanosized objects. Nanorobots plays a critical roles for many applications in the human body, such astargetingtumoral lesionsfor therapeutic purposes, miniaturization of the power source with an effective onboard controllable propulsion and steering system have prevented the implementation of such mobile robots.

The therapeutic properties of light have been known for thousands of years, but it was only in the last century that photodynamic therapy (PDT) was developed. It is an emerging modality for the treatment of a variety of diseases that require the killing of pathological cells (e.g. cancer cells or infectious micro-organisms) or the removal of unwanted tissue (e.g. neovascularization in the choroid or atherosclerotic plaques in the arteries). It is based on the excitation of nontoxic photosensitizers.Photodynamic therapy(PDT) uses the combination of dyes with visible light to produce reactive oxygen species and kill bacteria and destroy unwanted tissue. Nanotechnology plays a great role insolubilizing thephotosensitizers, metal nanoparticles can carry out Plasmon resonance enhancement, andfullerenescan act as photosensitizers, themselves.

Nanotechnology is becoming increasingly important for the several sectors. Promising results and applications are already being developed in the areas of nutrient delivery systems through bioactive Nano encapsulation,biosensorsto detect and quantifypathogens organic compounds. The sensitivity and performance of biosensors is being improved by using nanomaterials for their construction. The use of these nanomaterials has allowed the introduction of many new signal transduction technologies in biosensors. Many scientists have involved themselves to know the application and the benefits of nanotechnology in different areas of food industry that include bioactive Nano encapsulation, edible thin film, packages andNano sensors.

Green chemistry and Nano science are both emerging fields that take advantage of molecular-level designing and have enormous potential for advancing our science. Nano science is the study of materials that are on the length-scale of 100 nanometers or smaller and have properties that are dependent on their physical size. The principles of green chemistry can guide responsible development of Nano science, while the new strategies of Nano science can fuel the development ofgreener productsand processes.Phytochemicalsoccluded in tea have been extensively used as dietary supplements and as naturalpharmaceuticalsin the treatment The parallel development of green chemistry and Nano science and the potential synergy of the two fields can lead to more successful and profitable technologies with reduced environmental impacts and improved conservation of resources. In recent years, green synthesis ofmetal nanoparticlesis an interesting issue of the nanoscience.

Nanotechnologyis enabling technology that deals with Nano-meter sized objects. It is expected that nanotechnology will be developed at several levels: materials, devices and systems. The combination of biology and nanotechnology has led to a new generation ofNano devicesthat opens the possibility to characterize the chemical, physical, mechanical, and other molecular properties. And it can be even used to characterize the single molecules or cells at extraordinarily high throughput.Nanoparticleswith distinctive chemical compositions, sizes, shapes, and surface chemistries can be engineered easily and this technique has wide range of applications in biological systems.Utility of nanotechnology to biomedical sciences imply creation of materials and devices designed tointeraction in sub-cellular scaleswith a high degree of specificity.

Biopolymer nanoparticles are offering numerous advantages which embrace the simplicity of their preparation from well-understood biodegradable, biocompatible polymers and their high stability inbiological fluidsduring storage. Since the emergence of Nanotechnology in the past decades, the development and design of organic andbioorganic nanomaterialshas become an important field of research. And several types of polymers have been tested and are used in drug delivery systems; including nanoparticles, dendrimers, capsosomes and micelles. Researchers have found, the synthesized polymers even serves as a good carrier and plays a vital role in carrying a drug. And in other hand they are used in food industries too for food package purposes. There are thousands of organic chemicals are in present in various pharmaceutical to consumer product and are being used in dyes, flavoring agents. It can be explained in organic compounds ranging in diameter from 10 to 1m.Ultrafine particlesare the same asnanoparticlesand between 1 and 100 nanometers in size, fine particles are sized between 100 and 2,500 nanometers, and coarse particles cover a range between 2,500 and 10,000nanometers.

The biological synthesis ofnanoparticlesis synthesis method through which we can control, size and shape of nanoparticles and it increasingly regarded as a rapid, ecofriendly, and easily scaled-up technology. Over the past few years researches have shown their interest inmetallic nanoparticlesand their synthesis has greatly increased. However, drawbacks such as the involvement oftoxic chemicalsand the high-energy requirements of production. Synthesizing living organisms such as bacteria, fungi and plants is an alternative way to overcome the drawbacks. Plant mediated synthesis of nanoparticles is the green chemistry that connects. Generally, metal nanoparticles are synthesized and stabilized by using physical and chemical: the chemical approach, such as chemical reduction,electrochemical techniques,photochemical reactionsin reverse micelles. There is a growing attention to biosynthesis the metal nanoparticles using organisms. Among these organisms, plants seem to be the best candidate and they are suitable for large scale biosynthesis of nanoparticles.

Nanoparticles used asdrug deliveryvehicles are generally below 100 nm , and are coated with different biodegradable materials such as natural or synthetic polymers (PEG,PVA,PLGA,etc.), lipids, or metals , it plays significant role on cancer treatment as well as it holds tremendous potential as an effective drug delivery system. A targeted drug delivery system (TDDS) is a system, which releases the drug in a controlled manner. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. To achieve efficient drug delivery it is important to understand the interactions ofNanomaterialswith the biological environment, targetingcell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents. Nanotechnology refers to structures roughly in the 1100 nm size regime in at least one dimension. Despite this size restriction, nanotechnology commonly refers to structures that are up to several hundred nanometers in size and that are developed bytop-down or bottom-up engineering of individual components.

Nanosuspention formulation can be used to improve the solubility of the poorly soluble drugs. One of the major problems associated with poorly soluble drugs is very low bioavailability. The Preparation ofNanosuspentionis simple and applicable to all drugs which are water insoluble. It consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion . Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction,crystal engineering, salt formation, solid dispersion, use ofsurfactant, complexation A range of parameters like solubility, stability at room temperature, compatibility with solvent, excipient, andphotostabilityplay a critical role in the successful formulation of drugs. Use of some drug which is potentially restricted because of its toxic side-effects and its poor solubility, making it unsuitable for intravenous use in patients withdrug malabsorption.

Nano medicine drives the convergence of nanotechnology and medicine it is delineated as the application of nanotechnology in healthcare. The field of tissue engineering has developed in phases: initially researchers searched for inert biomaterialsto act solely as replacement structures in the body. Tissue engineering is classified as an associate field of biomaterialsand engineering. It focuses on the use of cellular and material-based therapies aimed attargeted tissue regenerationcaused by traumatic, degenerative, and genetic disorders.It covers a broad range of applications, in practice the term has come to represent applications that repair or replace structural tissues (i.e., bone, cartilage, blood vessels, bladder, etc.). Today, these Nano scale technologies are coming to the forefront in medicine because of their biocompatibility, tissue-specificity, and integration and ability to act as therapeutic carriers.

Polymeric nanoparticles (NPs) are one of the most studied organic strategies for Nano medicine. Intense interest lies in the potential ofpolymeric NPsto revolutionize modern medicine. Polymeric NPs include drug delivery techniques such as conjugation and entrapment of drugs,prodrugs, stimuli-responsive systems,imaging modalities, and theranostics.The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significanttherapeutic potential. Concurrently, targeted delivery technologies are becoming increasingly important as a scientific area of investigation. Polymericnanoparticles-based therapeutics show great promise in the treatment of a wide range of diseases, due to the flexibility in which their structures can be modified, with intricate definition over their compositions, structures and properties. Advances in polymerizationchemistries and the application of reactive, efficient andorthogonal chemicalmodification reactionshave enabled the engineering of multifunctional polymericnanoparticles.

In recent years,microbubbleand Nano bubble technologies have drawn great attention due to their wide applications in many fields of science and technology, such as water treatment,biomedical engineering, and nanomaterials.Nano bubblesexhibit unique characteristics; due to their minute size and high internal pressure, they can remain stable in water for prolonged periods of time. Nanobubbles can be created whengold nanoparticlesare struck by short laser pulses. The short-lived bubbles are very bright and can be made smaller or larger by varying the power of the laser. Because they are visible under a microscope, nanobubbles can be used to either diagnose sick cells or to track the explosions that are destroying them.

Natural productshave been used in medicine for many years. Many top-sellingpharmaceuticalsare natural compounds or their derivatives.. And plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. Natural products had huge success in the post-World War II era as antibiotics, and the two terms have become synonymous.While large pharmaceutical companies have favored screening synthetic compound libraries for drug discovery, small companies have started to explore natural products uses against cancer, microbial infection, inflammation, and other diseases.The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products bothin vitro and in vivo.

Nanoscience and nanotechnology are new frontiers of this century and food nanotechnology is an emerging technology. Food technology is regarded as one of the industry sectors where nanotechnology will play an important role in the future. The development of new products and applications involving nanotechnologies holds great promise in different industrial sectors, Nanotechnology may revolutionize the food industry by providing stronger, high-barrier packaging materials, more potentantimicrobial agents. Several possibilities exist to exploit the benefits of nanotechnologies during different phases of the food chain with the aim to enhance animal nutrition and health. Several complex set of engineering and scientific challenges in the food and bioprocessing industries for manufacturing high quality and safe food through efficient and sustainable means can be solved through nanotechnology. Bacteria identification and food quality monitoring using biosensors; intelligent, active, and smart food packaging systems; and Nanoencapsulationofbioactive food compoundsare few examples of emerging applications of nanotechnology for the food industry.

The main current applications of Nanotechnology for surgeons are in the areas of development of surgical implants using Nanomaterials, Imaging, Drug Delivery and development of Tissue Engineering products, such as scaffolds with enhanced materialcell interaction. An example of this is the development of a scaffold for delivery of stem cells to replace defective retinal pigmented epithelial cells in age-related Macular Degeneration. In Dentistry research has been done, liposomal Nanoparticles that contained collagenase and performed tests with them in rats, and found compared to conventional surgery, collagenase weakened the collagen fibers, making it easier to shift the teeth afterward with braces.

Nanoparticles with their unique size-dependent properties are at the forefront of advanced material engineering applications in several fields. Metals, non-metals, bio-ceramics, and manypolymeric materialsare used to produce nanoparticles of the respective materials. These are functional in producing liposomes, PEG and many more. Due to their small size nanoparticles has found to be interacting with human bodies same like of gases. Nanoparticles of the same composition can display behavioral differences when interacting with different environments. Nanoparticles can enter the human body via inhalation, ingestion, or skin contact. The range of pathologiesrelated to exposure tonanoparticles encompasses respiratoryand even several organs and leads to diseases. Accurate in vitro assessment ofnanoparticle cytotoxicityrequires a careful selection of the test systems. Due to high adsorption capacity and optical activity, engineered nanoparticles are highly potential in influencing classical cytotoxicity assays.

One of the exciting features of nanotechnology is its utility in the field of Nano medicine, therapeutics, and medical devices . When these small size materials are introduced into biological systems, their extremely small size and their unique Nano scale properties make it possible to use them as delivery vectors and probes for biological diagnostics,bioimagingand therapeutics. In fact, when size decreases, thesurface area to volume ratioof materials becomes very large, so that a vast suitable surface is available forchemical interactions withbiomolecules. This critically implied that nanotechnology is facing a transition into the tangible advancement ofhuman therapeutics. Recently, There are multiple clinical trials of nanomaterials have done; both for therapeutics and for medical devices.

Related conferences: Nanomedicine Conferences | Nanotechnology Events | Nano Healthcare Congress | Nanomedicine Meet | Nanoscience Event | Nanoengineering Conference | Tissue Engineering Meeting

Related Societies:

USA:International Organization of Materials, International Association of Nanotechnology, Graphene Stakeholders Association, Nano Science and Technology Institute (NSTI),NanoBusiness Commercialization Association, Alliance for Nanotechnology in Cancer,International association of nanotechnology,National Institute for Nanotechnology, Waterloo Institute for Nanotechnology, The Institute for Molecular Manufacturing (IMM),NanoBusiness Alliance, Nanotechnology and Nanoscience Student Association (NANSA),Nano Science and Technology Institute (NSTI),National Cancer Institute, National Nanotechnology Initiative,American Nano society, Metals and Minerals Societies, Society for Advancement of Material and process Engineering,American Composites Manufacturers Association, Brazilian Composites Materials Association,Canadian Biomaterials Society, American Institute of Aeronautics and Astronautics (AIAA).

Europe:International Union of Crystallography, European Nanoscience and Nanotechnology Association (ENNA),German Association of Nanotechnology, Nanotechnology Industries Association, The Institute of Nanotechnology (IoN), Nanotechnology Industries Association (NIA),Russian Society of Scanning Probe Microscopy and Nanotechnology, Society of Nanoscience and Nanotechnology, Federation of Materials Societies, Society for Biomaterials, Federation of European Materials Societies

Asia-Pacific & Middle East:Nano Technology Research Association (NTRA), Asian Nanoscience and Nanotechnology Association (ANNA), Nanoscience & Nanotechnology, ASPEN-Asian society of precision engineering and nanotechology, The International Association of Nanotechnology (IANT), Iran Nanotechnology Initiative Council (INIC), National Institutes of Health, Society of Materials Science, Japan Society for Composite Materials, Australasian Society for Biomaterials and Tissue Engineering, Australasian Ceramic Society, Materials Research Society, National Centre for Nanoscience and Technology.

Theme: Role of Nanotechnology in Humans life

Summary:

The field of Nanotechnology has recently emerged as the most commercially viable technology of this century because of its wide-ranging applications in our daily lives. Man-made Nanostructured materials such as fullerenes, nanoparticles, Nano powders, Nanotubes, Nanowires, Nanorods, Nano-fibers, Quantum dots, Dendrimers, Nano clusters, Nanocrystals, and Nanocomposites are globally produced in large quantities due to their wide potential applications, e.g., in skincare and consumer products, healthcare, electronics, photonics, biotechnology, engineering products, Pharmaceuticals, drug delivery, and agriculture. Many emerging economies such as Brazil, China, India, Iran, UAE, Malaysia, Mexico, Singapore and South Africa have ambitious research and development (R&D) plans for Nanotechnology.A group of scientists who have mapped out the uses of Nanotechnology and the needs of global health argue that Nano medicine is relevant for the developing world. They surveyed researchers worldwide and concluded that Nanotechnology could greatly contribute to meeting the Millennium Development Goals for health.

Importance and scope:

Nanotechnologyis becoming a crucial driving force behind innovation in medicine and healthcare, with a range of advances including Nano scale therapeutics, biosensors, implantable devices, drug delivery systems, and imaging technologies. Universities also have begun to offer dedicated Nano medicine degree programs (example:MSc program in Nanotechnology for Medicine and Health Care). Nanotechnology will be getting to be progressively prevalent these times Around learners. Actually, if you follow again of the Inception about nanotechnology, you will discover that Ayurveda need long been utilizing gold Also silver nanoparticles, known as bhasmas, to treat Different therapeutic ailments. Presently, nanotechnology may be generally utilized within huge numbers industries, going from cosmetics, agriculture, and materials should pharmaceutical Also human services. Nanomedicine may be the provision for nanotechnology for those diagnoses, detection, and medicine Also aversion of illnesses. Presently there need aid various items on the business that would the outcome from claiming nanotechnology. Talking for scratching the surface, we likewise have Nano auto wax that fills done the individuals minor cracks more successfully Furthermore provides for you a shinier vehicle. There need aid likewise Nano items accessible with stay with your eyewear What's more different optical units cleaner, dryer, What's more that's only the tip of the iceberg tough.

Conference highlights:

Why in Abu Dhabi?

Abu Dhabi is the federal capital and centre of government in the United Arab Emirates sits off the mainland on an island in the Persian (Arabian) Gulf. It is the largest city of the Emirate of Abu Dhabi and one of the most modern cities in the world. It is a well-ordered, industrious city with a pretty waterside location. Innovative Nano Technology LLC was founded in the beginning of 2016 in Al Ain City, Abu Dhabi, United Arab Emirates. It was established with the goal of taking a leading role in the field of Nano Technology Based Coatings, and is considered as one of the first Companies who offer the new Nano technology based Coatings in the region.

Why to attend?

United Arab Emirates has a number of universities that offer research and educational opportunities in nanotechnology. United Arab Emirates University, The first and foremost comprehensive National University in the United Arab Emirates. eFORS office is the University consultancy office within the college of engineering that deals with several science and technology issues including Biochemical and Biopharmaceutical Processes and Bioengineering and Nanotechnology. Reports released during October 2012 revealed that the worlds second largest foundry, Globalfoundries has agreed to partner with Masdar Institute to develop Abu Dhabi as a centre for semiconductor R&D and manufacturing excellence. In September, the company allowed students and professors to use its technology facilities at its Abu Dhabi branch. The facilities have a laboratory-like environment with powerful production servers, engineering work stations and a high-speed data network that can be used for enabling remote access to very advanced nanotechnology engineering systems

Technology domains of patent applications in UAE

This graph shows the global Nanomedicine market size, measured in terms of revenues, such as sales revenues, grants revenues, and milestones. From2006to date, a steady growth has occurred, which is expected to continue through2014, at aCAGRof13.5% [BCCResearch, Nanotechnology in Medical Applications. The drug delivery market is the largest contributing application segment, whereas biomaterials are the fastest growing application area in this market. Nanomedicine accounts for77Marketed Products Worldwide, representing an Industry with an estimated market $249.9Billion by2016[ETPNdata,BCC].

Globally, the industry players would centering essentially once R&D to get Regard for Different clinical trials for future Nanodrugs with a chance to be economically accessible in the business sector. If a chance to be generally arranged for exactly of the most punctual What's more The greater part essential requisitions of Nano medicine for regions for example, gene treatment and tissue building. The a greater amount propelled requisitions for Nano medicine will pose interesting tests As far as order Furthermore support about exploratory dexterity.

Nano medicine market :

Nano-enabled medical products beganappearing on the market over a decade ago and some have become best-sellers in theirtherapeutic categories. The main areas in which Nanomedical products have made animpact are cancer, CNS diseases, cardiovascular disease, and infection control. At present, cancer is one of the largesttherapeutic areas in which Nano-enabled products have made major contributions; theseinclude Abraxane, Depocyt, Oncospar, Doxil,and Neulasta. Cancer is a prime focus forNano pharmaceutical R&D, and companieswith clinical-stage developments in this fieldinclude Celgene, Access, Camurus, andCytimmune. Treatments for CNS disorders includingAlzheimers disease and stroke also feature prominently in Nano therapeutic research,seeking to build on achievements already posted by products such as Tysabri, Copazone,and Diprivan. According to BCC Research,this is a field hungry for successfultherapeutic advances and annual growth fromexisting and advanced pipeline products isexpected to reach 16% over the next 5 years.

Nanotechnology Companies in Asia and Middle East:

Nano Congress 2017

We gratefully thank all our wonderful Speakers, Conference Attendees, Students, Media Partners, Associations and Sponsors for making Nano Congress 2017 Conference the best ever!

The19thNano Congress for Next Generation, hosted by the ME Conferences was held duringAugust 31- September 01, 2017atBrussels, Belgiumbased on the themeNext Generation Nanotechnology Concepts Methodologies Tools and Applications". Benevolent response and active participation was received from the Organizing Committee Members along with Scientists, Researchers, Students and leaders from various fields of Nanotechnology who made this event a grand success.

ME Conferences expresses its gratitude to the conference Moderator,namelyDr.Dominique Ausserrefor taking up the responsibility to coordinate during the sessions. We are indebted to your support.

Similarly we also extend our appreciation towards our Poster judge namely,Dr. Arturs Medvids.

The conference was initiated with theHonorable presenceof theKeynote forum. The list includes:

The meeting reflected various sessions, in which discussions were held on the following major scientific tracks:

Nano Materials Synthesis and Characterisation

Nano Photonics

Molecular Nanotechnology

Nanotechnology and Cosmetics

Nanotechnology in Agriculture and Food Industry

Carbon Based Nano materials and Devices

Nanotechnology Safety

Nano Medicine and Nano Biotechnology

Nano Science and Technology

Nano Applications

Nano-electronics

Nano Biomaterials

Nano Biometric

Advanced Nanomaterials

Nano Technology in Tissue Engineering

Nanotech for Energy and Environment

Nano Computational Modelling

ME Conferences offers its heartfelt appreciation to organizations such asAllied Academies,Andrew John Publishing Inc.,New York private Equity Forum,Crowd Reviewsand other eminent personalities who supported the conference by promoting in various modes online and offline which helped the conference reach every nook and corner of the globe. ME Conferences also took privilege to felicitate the Keynote Speakers, Organizing Committee Members, Chairs and sponsors who supported this event

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Adult Stem Cell Medicine Technology | Asymmetrex

Posted: October 8, 2018 at 2:44 pm

Asymmetrex is a life sciences biotechnology company with a focus on innovating adult stem cell medicine technology that will advance the potential of adult tissue stem cells into routine medical practice. Adult tissue stem cells are found in the bodies of children and adults. They are a small fraction of the cells (less than 1 per 1000) that make up organs and tissues like the liver, cornea, skin, muscles, hair, brain, and bone marrow. Despite their small fraction, they are responsible for continuously renewing and repairing the body.

Because of their normal role in maintaining and restoring organs and tissues, tissue stem cells obtained from a donating person have an inherent ability to reconstitute severely damaged tissues due to injury or disease in another recipient person. Currently, tissue stem cell transplantation treatments of this type are only available for a few tissues, e.g., bone marrow and the cornea of the eye. There are many, many more tissues in the body for which stem cell transplantation therapies are needed, but not possible. The major cause of this shortcoming insufficient quantities of donor stem cells often also undermines the effectiveness of the tissue stem cell treatments that are available.

Asymmetrex holds adult stem cell patents for technologies that promotethe multiplication of adult tissue stem cells. Tested so far for tissue stem cells found in the liver, lung, pancreas, muscle, skin and hair follicle, the technologies have the potential to produce therapeutic human tissue stem cells by the pound, trillions of cells at a time. Unlike other presently popularized strategies based on pluripotent stem cells, Asymmetrexsadult stem cell medicine technologyproducesnormal cells without high rates of mutation or tumor-forming properties. A major pursuit of Asymmetrex is collaboration with strategic partners to develop robust manufacturing processes for producing medically important tissue stem cells and their differentiated derivative cells for use in transplantation therapies and drug development.

Another long-standing challenge in stem cell biomedicine is lack of means to identify and count tissue stem cells. Because of this need, even the available tissue stem cell therapies like bone marrow transplantation cannot be reliably optimized to achieve better treatment outcomes. This problem has existed for half a century because of the failure to discover biological markers found exclusively in or on adult tissue stem cells.

Employing its internationally recognized, special research expertise in unique adult tissue stem cell properties, Asymmetrex has developed several technologies that make it now possible to either count tissue stem cells directly or estimate their number precisely. This adult stem cell medicine technologyand innovation provide, for the first time, the means to monitor tissue stem cell number and quality for applications in regenerative medicine and drug development.

By continuing to discover and develop adult stem cell medicine technology for the production, identification, and quantification of restorative adult tissue stem cells, Asymmetrex will set the direction and pace of modern stem cell biomedicine. In addition to our current focus in developing stem cell toxicology assays for the pharmaceutical industry, we also license technologies for stem cell detection (including cancer stem cells) and stem cell expansion for user-exclusive applications.

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Adult Stem Cell Medicine Technology | Asymmetrex

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Stem Cell Therapy in York County, Pennsylvania

Posted: October 8, 2018 at 2:43 pm

Degenerative joint conditions and injuries causing constant pain is typically alleviated through invasive surgery. Wouldnt it be more convenient if there was a way to cure your ailments without the inconvenience of a major procedure? Advancements have helped us find a way to achieve this through specialized therapy, using stem cells and blood platelets from your own body.

Our breakthrough technique does not require going through surgery, and treatment is completed in a single day. Existing cells are harvested and then replaced back into the body to immediately begin treated your condition. Patients are left with a greater sense of comfort once their injuries have the opportunity to heal properly.

Nagging shoulder pain is typically caused by previous injuries that failed to heal properly. Doctors offer surgery, but it has a considerably low success rate of completely repairing the internal issues after enduring a lengthy recovery. Traditional surgery for the shoulder can be difficult because of the complexity of the joint, and it often requires a painful, lengthy rehabilitation process to restore the full range of motion.

Stem cell therapy for shoulders may be an ideal nonsurgical alternative for those who suffer from shoulder pain because of a rotator cuff injury or pain related to osteoarthritis, or muscle sprains and strains. Non-surgical stem cell treatment targets the damage and promotes regeneration without any inconvenient side effects.

Rotator Cuff Tears

AC Joint Separation

Arthritis of the shoulder joint

Labral tears / degeneration

Rotator Cuff Tendonitis

Recurrent Shoulder Dislocations

Mild to moderate osteoarthritis

Thoracic outlet syndrome

If you spent earlier years engaging in sports, its very likely that youll develop some degree of pain from the stress on your knees. Its easy to tear cartilage, injure a ligament, or feel the ache of arthritis even if you dont realize youve overworked yourself. Blood platelet treatments stimulate natural regeneration to help patients avoid invasive ligament repairs or joint replacements.

While cortisone and other drugs only provide temporary pain relief, stem cells actually restore degenerated tissue while providing pain relief. The growth factors in amniotic stem cells may replace damaged cells in your body. Additionally, stem cell injections contain hyaluronic acid, which lubricates joints and tendons, easing the pain and helping restore mobility.

Arthritis / Osteoarthritis

MCL, ACL, PCL, or LCL sprain or tear

Knee instability

Hamstrings Tendinopathy

Cartilage Damage

Patellar Tendonitis

Meniscus Tear

Pes Anserine Bursitis

There is no way to avoid the symptoms of hip pain once you have suffered from an injury to the joint or surrounding tendons. Hip pain can be very difficult to deal with on a day-to-day basis and traditionally requires long-term pain management if the problem is not corrected.

As a hip surgery alternative, stem cell therapy may help you to return to daily activities that were difficult before the treatment using a simple in-office injection procedure. Our approach works without surgery by amplifying the concentration of a persons own stem cells in the problem area, boosting the bodys ability to heal itself naturally. Our patients are typically encouraged to walk the same day, and most experience little to no down time from the procedure.

Avascular Necrosis

Osteonecrosis

Bursitis

Arthritis

Tendinopathy

Labral / labrum tear

Wrist and hand surgeries can be complicated and painful. Besides the risks and cost of the surgeries, a long rehabilitation is usually required. Many a times the functionality never completely returns after these surgeries. The main reason individuals experience torn ligaments and other injuries in their wrist area is the lack of cushion in such a compact spot. Everyday activities, such as typing, constantly add unnecessary strain that will eventually require treatment to alleviate. We recommend stem cell therapy to help your body naturally heal in a simple procedure.

Instability

Arthritis

Carpal Tunnel

Its never the wrong time to finally put a stop to your physical suffering with the help of our talented surgeons. Simply fill out the contact form so that we can determine if you are eligible for the non-surgical treatment we offer.

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Department of Microbiology and Molecular Genetics

Posted: October 7, 2018 at 4:47 pm

I welcome you to the Department of Microbiology and Molecular Genetics. Our department is uniquely positioned in two colleges at the University of Vermont: the Robert Larner, M.D., College of Medicine (LCOM) and the College of Agriculture and Life Sciences (CALS). At CALS, MMG hosts two outstanding undergraduate majors, Microbiology and Molecular Genetics. Our highly-recognized faculty educators work closely with our undergraduate students throughout their years at UVM as they become excellent scientists and innovative, critical thinkers. At LCOM, our faculty are closely engaged with teaching and training medical students, as well as graduate students, in our Cellular, Molecular and Biomedical Sciences (CMB) Ph.D. program and Medical Masters program.

Our faculty are highly focused on research, which spans from basic-science inquiry in the fields of Microbiology; Cell, Molecular and Structural biology; to applied and translational research in human immunology, vaccine, and bioinformatics and genetics. MMG hosts a nationally recognized team exploring the mechanisms of DNA Repair, research that is critically important to human diseases, including cancer. The recent addition of the UVM Vaccine Testing Center team to MMG complements our research portfolio by adding significant new depth in clinical and translational human immunology and vaccinology, as well as U.S.-based and international clinical trials, all with a focus on preventing and controlling infectious diseases of global importance.

Thank you for your interest in MMG. We look forward to hearing from you!

Beth Kirkpatrick, M.D.Professor and Chair, Department of Microbiology and Molecular GeneticsDirector, Vaccine Testing Center

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Department of Microbiology and Molecular Genetics

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