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Stem Cells & Diseases – Nebraska Coalition for Lifesaving …

Posted: October 5, 2018 at 6:40 am

Diabetes is a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. Insulin is a cellular protein that regulates glucose levels in the blood.

Type 1 diabetes is often called juvenile diabetes because it generally appears during childhood or adolescence. It develops when the bodys immune system mistakenly destroys the insulin-producing islet cells of the pancreas, a small gland behind the stomach. As a result, the body is unable to properly utilize energy in food or control sugar levels in the blood stream.

Type 1 diabetics must endure many painful insulin injections each day in order to live and function normally and, at present, there is no cure. However, recent research indicates that a cure may be possible through transplants of pancreatic islet cells.

Type 2 diabetes usually begins as insulin resistance, a disorder in which the cells do not use insulin properly. As the need for insulin rises, the pancreas gradually loses the ability to produce it. This type of diabetes usually occurs later in life, affecting 90% of patients diagnosed with diabetes.

Type 2 diabetes is associated with older age, obesity, family history of diabetes, physical inactivity and race/ethnicity. African Americans, Hispanic/Latino Americans, Native Americans, and some Asian Americans, Native Hawaiian or other Pacific Islanders are at particularly high risk for Type 2 diabetes. Type 2 diabetes is also increasingly being diagnosed in children and adolescents. Current treatment includes using diabetes medicines, making wise food choices, exercising regularly, taking aspirin daily, and controlling blood pressure and cholesterol.

Diabetes can lead to many serious long-term health problems and early death. It can cause blindness, kidney failure and severe problems involving the gums and teeth. It can also cause nerve damage and blood flow problems that result in impaired sensation or pain in the feet or hands and amputation of limbs. One of the most serious problems caused by diabetes is heart disease. People who have diabetes are more than twice as likely to develop heart disease or a stroke as people without diabetes.

Over 18 million people in the U.S., or 6.3% of the population, have diabetes. Over one million new cases are diagnosed every year. Diabetes was the sixth leading cause of death listed on U.S. death certificates in 2000. The American Diabetes Association estimates that diabetes contributes to over 200,000 deaths annually nationwide. However, total deaths caused by diabetes are probably under-reported because it ultimately causes other health problems that may be listed as the cause of death.

In 2000, a total of 129,183 people with diabetes underwent dialysis or kidney transplantation. About 60% to 70% of people with diabetes have mild to severe forms of nervous system damage. The results of such damage include slowed digestion of food in the stomach, carpal tunnel syndrome and other nerve problems.

Its estimated that diabetes costs Americans a total of $132 billion annually, including $92 billion in direct medical costs and $40 billion in costs related to disability, work loss and premature death. Diabetes accounts for one of every four Medicare dollars spent in the U.S.

The Kaiser Family Foundation estimates that 6% of adults between the ages of 18 and over 75 in our state have diabetes. The majority of adults diagnosed with diabetes are between the ages of 45 and 64 (43%) and age 65 and older (42%). Most of these older patients have Type 2 diabetes.

More than 50 years of research on adult stem cells, taken from adult tissues, has produced such lifesaving treatments as bone marrow transplants for leukaemia patients. And, adult stem cells are likely to provide additional cures for some diseases in the years ahead.

However, the new frontier in stem cell research involves early, or embryonic, stem cells (ES cells). Unlike adult stem cells, ES cells have the potential to turn into and regenerate any type of cell or tissue in the human body. As a result, ES cells could provide cures for many currently incurable or common diseases and injuries that cannot be cured with adult stem cells, or more effective treatments than adult stem cells may provide.

There are two basic sources of ES cells for such potential therapies. One source is the leftover embryos at fertility clinics that would otherwise be discarded and destroyed. ES cells can also be produced with Somatic Cell Nuclear Transfer (SCNT), a process that uses a patients own cells and an unfertilized human egg to make ES cells. SCNT has the added advantage of producing ES cells that will automatically match the patients genetic makeup. As a result, SCNT avoids the need to find a genetically matching donor and the problem of immune system rejection, two limitations associated with donated adult and ES cells.

Indications that ES cells could benefit diabetes patients have been provided by a number of recent studies. For example, researchers at Stanford University have successfully turned mouse ES cells into insulin-making tissue that kept diabetic mice alive.

Other research has shown that insulin-producing islet cells can be transplanted into patients with Type 1 diabetes and that such transplants could potentially provide a cure. However, the only current source of replacement islet cells is from human cadavers and not enough donated islet cells are available from this source to treat the many children and adults who have Type 1 diabetes. In addition, because donated islet cells are not a perfect genetic match with the patients DNA, patients who receive donated islet cells must take powerful drugs to prevent rejection. These drugs have severe and potentially fatal side effects and rejection often occurs despite the medication.

SCNT could help overcome these limitations and revolutionize the treatment of juvenile diabetes by providing a way to make virtually unlimited supplies of transplantable islet cells that match a patients DNA.

In the future, transplants of ES cells could also help people who suffer from Type 2 diabetes. For example, ES cells could be used to help repair tissues and organs that are damaged by effects of Type 2 diabetes and alleviate some of the health problems associated with this disease.

SCNT could also play an important role in developing future gene therapy treatments for inherited diseases like Type 1 diabetes, which develop because the patient has an abnormal or malfunctioning gene. If the gene that causes a disease can be identified, scientists could take a patients somatic cell, such as a skin cell, and replace the defective gene with a normal gene inserted using recombinant DNA techniques. The corrected cell could then be used in the SCNT procedure to generate stem cells with normally functioning genes. These could then be directed to develop into islet cells and put back into the patients body, potentially providing a cure. This technique would overcome some of the most difficult hurdles facing gene therapy today.

In addition, SCNT has given medical researchers a method of growing cells that have the defects associated with a disease in a laboratory setting. This use of SCNT provides new ways to study how a disease like diabetes progresses at the cellular level and to test the effectiveness of new drugs or other treatments that may cure or slow the progress of the disease.

The consensus of the medical and patient community is that all types of stem cell research should be pursued in the effort to find cures for diseases like diabetes, and that ES cells can play an important role in this effort.

Thats why ES cell research is strongly supported by the overwhelming majority of medical researchers; medical organizations like the American Medical Association; and disease and patient advocacy groups like the American Diabetes Association, Juvenile Diabetes Research Foundation and Diabetes Research Institute Foundation.

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Stem Cell Therapy North Carolina | Regenerative Medicine …

Posted: October 4, 2018 at 12:43 am

About Us

Historically, joint-pain sufferers were told that joint replacement surgery, an often painful and sometimes uncertain treatment with potential for complications and long-term recovery, was their only relief.

But history has changed.

Regenerative Medicine Clinic of Wilmington (Regen Med), the regions first and only regenerative medicine-dedicated clinic, offers a non-surgical joint pain treatment option using the bodys own cells to repair damaged or injured areas, thus delaying or completely eliminating the need for surgery.

Regenerative medicine takes advantage of the full complement of non-surgical treatment options, from rest and Tylenol to cartilage restoration (ACI) to cellular- and molecular-based therapies for arthritic joint pain (CBT).

We were first nationally to use stem cells in the treatment of shoulder disorders and first in southeastern North Carolina to introduce stem cell science and technology. Regen Meds fellowship-trained orthopedic surgeon and regenerative medicine expert Austin Yeargan III, MD, has been named one of the top 10 Orthopedic leaders to know in internationally published Beckers Orthopedic & Spine Review.

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Regrowing dental tissue with stem cells from baby teeth …

Posted: October 2, 2018 at 6:45 pm

Sometimes kids trip and fall, and their teeth take the hit. Nearly half of children suffer some injury to a tooth during childhood. When that trauma affects an immature permanent tooth, it can hinder blood supply and root development, resulting in what is essentially a dead tooth.

Until now, the standard of care has entailed a procedure called apexification that encourages further root development, but it does not replace the lost tissue from the injury and, even in a best-case scenario, causes root development to proceed abnormally.

New results of a clinical trial, jointly led by Songtao Shi of the University of Pennsylvania and Yan Jin, Kun Xuan, and Bei Li of the Fourth Military Medicine University in Xian, China, suggest that there is a more promising path for children with these types of injuries: using stem cells extracted from the patients baby teeth. The work was published in the journal Science Translational Medicine.

This treatment gives patients sensation back in their teeth. If you give them a warm or cold stimulation, they can feel it; they have living teeth again, says Shi, professor and chair in the Department of Anatomy and Cell Biology in Penns School of Dental Medicine. So far we have follow-up data for two, two and a half, even three years, and have shown its a safe and effective therapy.

Shi has been working for a decade to test the possibilities of dental stem cells after discovering them in his daughters baby tooth. He and colleagues have learned more about how these dental stem cells, officially called human deciduous pulp stem cells (hDPSC), work, and how they could be safely employed to regrow dental tissue, known as pulp.

The Phase 1trial was conducted in China, which has a research track for clinical trials.The 40 children enrolled had each injured one of their permanent incisors, and still had baby teeth. Thirty were assigned to hDPSC treatment and 10 to the control treatment, apexification.

Those whoreceived hDPSC treatment had tissue extracted from a healthy baby tooth. The stem cells from this pulp were allowed to reproduce in a laboratory culture, and the resulting cells were implanted into the injured tooth.

Upon follow-up, the researchers found that patients who received hDPSCs had more signs than the control group of healthy root development and thicker dentin, the hard part of a tooth beneath the enamel, as well as increased blood flow.

At the time the patients were initially seen, all had little sensation in the tissue of their injured teeth. A year following the procedure, only those who received hDPSCs had regained some sensation. Examining a variety of immune-system components, the team found no evidence of safety concerns.

As further support of the treatments efficacy, the researchers had the opportunity to directly examine the tissue of a treated tooth when the patient re-injured it, and had to have it extracted. They found that the implanted stem cells regenerated different components of dental pulp, including the cells that produce dentin, connective tissue, and blood vessels.

For me, the results are very exciting, Shi says. To see something we discovered take a step forward to potentially become a routine therapy in the clinic is gratifying.

It is, however, just a first step. While using a patients own stem cells reduces the chances of immune rejection, its not possible in adult patients who have lost all of their baby teeth. Shi and colleagues are beginning to test the use of allogenic stem cells, or cells donated from another person, to regenerate dental tissue in adults. They are also hoping to secure FDA approval to conduct clinical trials using hDPSCs in the United States.

Eventually, they see even broader applications of hDPSCs for treating systemic disease, such as lupus, which Shi has worked on before.

Were really eager to see what we can do in the dental field, Shi says, and then building on that to open up channels for systemic disease therapy.

The research was supported by the National Key Research and Development Program of China, the NaturalScience Foundation of China and a pilot grant from Penn Dental Medicine.

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Stem Cell Therapy in Arkansas | Arkansas Heart Hospital

Posted: October 1, 2018 at 11:46 pm

The Arkansas Institute for Stem Cell and Regenerative Medicine is providing leadership with the newest techniques in this field of technology using adult stem cells only. Offering therapy to patients with cardiovascular diseases or recent heart attack, orthopedic medicine and COPD (Chronic Obstructive Pulmonary Disease). Stem Cell therapy has been widely accepted for over 20 years in the treatment of other diseases in multiple sequences.

Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as an internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell or a brain cell.

Stem cells are distinguished from other cell types; they are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity. Stem Cells can be induced to become tissue or organ specific cells with special functions. In some organs, such as the intestines and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues.

Research shows the potential of stem cells to help patients with cardiovascular disease is abundant. The patients own regenerative stem cells can be injected into the veins, arteries, or directly into the heart muscle for the treatment of heart failure, heart attacks and peripheral vascular disease. Our trained nurses, technicians cardiologists and surgeons work as a dedicated team with each patient to review their options.

COMMON NEEDS FOR THERAPY INCLUDE:

CLINICAL MONITORING

Patients undergoing Stem Cell therapy for cardiovascular diseases will also have a series of pre- and post-procedure diagnostic tests to complete during the first monitored year.

The patients own regenerative stem cells are used to treat many types of chronic pain from shoulder, knee, hip and degenerative disk disease. After the harvesting procedure for regenerative cells in the abdominal fat, the surgeon will implant these at the site of injury. Clinical research shows that it is possible to use regenerative cells to effectively restore and repair damaged or aging cells and regenerate tissue in the body.

COMMON NEEDS FOR THERAPY INCLUDE:

CLINICAL MONITORINGPatients undergoing stem cell therapy for degenerative diseases will also have a series of pre- and post-procedure diagnostic tests to complete during the first monitored year.

Chronic Obstructive Pulmonary Disease (COPD) is a relatively common, often debilitating illness, which has a major impact on the people of the world. There are a number of treatments designed to alleviate symptoms, but there is no cure. Stem Cell therapy is designed and has the potential to treat the underlying issue of loss of lung tissue. Our research trial is designed to prove how much Stem Cell therapy improved COPD. Like some of the therapies already mentioned the patients own regenerative stem cells are harvested from the abdominal fat tissue and then injected back into the patient intra-vascularly.

COMMON NEEDS FOR THERAPY INCLUDE:

CLINICAL MONITORING

Pre and Post Procedure; All COPD patients will have a series of pre- and post-procedure lung function measurements collected by their treating physician. Patients will be asked to perform the lung function test at two, six and 12 months post procedure.

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Stem Cell Therapy in Arkansas | Arkansas Heart Hospital

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Colorado Stem Cell Therapy | Home

Posted: October 1, 2018 at 11:44 pm

Select a Problem Area

If you have pain, we're here to help. Regenexx Procedures are patented stem cell and blood platelet procedures that are used to treat a wide range of joint and spine conditions.

Click a problem area to discover what Regenexx can do for you.

The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from shoulder pain due to arthritis, rotator cuff and shoulder labrum tears, overuse injuries, and other degenerative conditions. Regenexx is also a viable alternative for those considering shoulder replacement surgery.

View Details About Shoulder Treatments

Commonly Treated Conditions:

Shoulder Procedure Video

Regenexx Procedures are advanced stem cell and blood platelet procedures for foot and ankle conditions. Before you consider ankle surgery, fusion or replacement, consider the worlds leading stem cell and prp injection treatments.

View Details About Foot & Ankle Treatments

Commonly Treated Conditions:

Ankle Procedure Video

The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from pain or reduced range of motion due to basal joint / cmc arthritis, hand arthritis, or other injuries & conditions in the hand.

View Details About Hand & Wrist Treatments

Commonly Treated Conditions:

The Regenexx family of non-surgical stem cell and blood platelet procedures offer next-generation injection treatments for those who are suffering from knee pain or may be facing knee surgery or knee replacement due to common injuries, arthritis, overuse and other conditions.

View Details About Knee Treatments

Commonly Treated Conditions:

ACL Procedure VideoIn-Depth with Dr. John Schultz ACL Procedure Video

The Regenexx family of non-surgical stem-cell & blood platelet procedures are next generation regenerative injection treatments for those who are suffering from pain, inflammation or reduced range of motion due tocommon elbow injuries, arthritis and overuse conditions.

View Details About Elbow Treatments

Commonly Treated Conditions:

The Regenexx family of hip surgery alternatives are breakthrough, non-surgical stem-cell treatments for people suffering from hip pain due to common injuries, hip arthritis & other degenerative problems related to the hip joint.

View Details About Hip Treatments

Commonly Treated Conditions:

Hip Labrum Procedure Video Hip Avascular Necrosis Procedure Video

Regenexx has many non-surgical platelet and stem cell based procedures developed to help patients avoid spine surgery and high dose epidural steroid side effects. These procedures utilize the patients own natural growth factors or stem cells to treat bulging or herniated discs, degenerative conditions in the spine, and other back and neck conditions that cause pain.

View Details About Spine Treatments

Commonly Treated Conditions:

Intradiscal Procedure Video

Regenexx has many non-surgical platelet and stem cell based procedures developed to help patients avoid spine surgery and high dose epidural steroid side effects. These procedures utilize the patients own natural growth factors or stem cells to treat bulging or herniated discs, degenerative conditions in the spine, and other back and neck conditions that cause pain.

View Details About Spine Treatments

Commonly Treated Conditions:

Cervical Spine Video

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Colorado Stem Cell Therapy | Home

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FAQ | Colorado Stem Cell Therapy

Posted: October 1, 2018 at 11:44 pm

As a leader in the advanced field of stem cell pain management, 5280 Advanced Health offers superior medical expertise and knowledge to treat patients with chronic pain. The field is relatively new and always growing, which is why we always strive to educate patients about their options and help them live a pain-free life.

Read answers to a few of our frequently asked questions below orcontact us to discuss your specific situation.

Does 5280 Advanced Health accept insurance?

All procedures are cash-based and we do not accept insurance.

Who are the candidates for stem cell therapy?

Stem cell therapy and hormonal optimization therapy may offer relief from patients suffering from chronic joint, spine and musculoskeletal pain who have failed less effective therapies.

What areas of the body does cellular treatment help?

Stem cell and othercellular therapies can target important joints such as in your knee, shoulder, hip, wrist, elbow, or ankle. It can also help treat the pain associated with acute sports injuries or spine and back problems that havent responded to other forms of therapy.

How is stem cell therapy in Colorado different from other pain management procedures?

Stem cells harvested from fat, blood and bone marrow are used to regrow and heal tissues such as ligaments, tendons, joints and spinal discs that are causing pain from osteoarthritis or degeneration. Stem cells use your bodys naturally produced cells to heal without invasive surgery or costly drugs.

Whats the best advice to help patients?

Our physicians advise all patients to exercise. The benefits of exercise include: weight control, reduce the risk of heart disease, reduce the risk of Type 2 Diabetes and metabolic syndrome, strengthen bones and muscles, and improve mental health and mood. There are no side-effects from exercise and it is free.

How do I get started?

The best way to get started is to call 5280 Advanced Health (720) 619-3144 between 8 am and 4 pm Mountain Time to schedule a consultation! You can also fill out our patient candidacy form and one of our team members will contact you as soon as possible.

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FAQ | Colorado Stem Cell Therapy

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Detroit Michigan Stem Cell Therapy – americanregen.com

Posted: September 28, 2018 at 9:41 am

Detroit Michigan Stem Cell Therapy

Stem Cell Therapy in Detroit Michigan is a process whereby stem cells from one area ofthe body are relocated to an area of injury or disease. In Stem Cell Therapy, therelocated stem cells form into the type of cell that the body needs to heal the injury.Stem Cell Therapy has the potential to not only heal the injury or disease, but alsoreverse the effect of diseases.

A variety of diseases are being treated by Stem Cell Therapy in Detroit Michigan. Diseasesand injuries range from COPD, arthritis, sports related injuries, Crohns Disease,neurological disorders and many more. The process by which Stem Cell Therapy takesplace in Detroit Michigan takes just a few hours. The cells are pulled through fat tissue orbone marrow in one area of the body, typically the pelvic area, and are immediatelydisposed into the area of the injury

If you would like to learn more about regenerative medicine or how it can help you, please call us at (248) 876-4242.

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Global catastrophic risk – Wikipedia

Posted: September 27, 2018 at 3:47 pm

Hypothetical future event that has the potential to damage human well-being on a global scale

A global catastrophic risk is a hypothetical future event which could damage human well-being on a global scale,[2] even crippling or destroying modern civilization.[3] An event that could cause human extinction or permanently and drastically curtail humanity's potential is known as an existential risk.[4]

Potential global catastrophic risks include anthropogenic risks, caused by humans (technology, governance, climate change), and natural or external risks.[3] Examples of technology risks are hostile artificial intelligence and destructive biotechnology or nanotechnology. Insufficient or malign global governance creates risks in the social and political domain, such as a global war, including nuclear holocaust, bioterrorism using genetically modified organisms, cyberterrorism destroying critical infrastructure like the electrical grid; or the failure to manage a natural pandemic. Problems and risks in the domain of earth system governance include global warming, environmental degradation, including extinction of species, famine as a result of non-equitable resource distribution, human overpopulation, crop failures and non-sustainable agriculture. Examples of non-anthropogenic risks are an asteroid impact event, a supervolcanic eruption, a lethal gamma-ray burst, a geomagnetic storm destroying electronic equipment, natural long-term climate change, or hostile extraterrestrial life.

Philosopher Nick Bostrom classifies risks according to their scope and intensity.[5] A "global catastrophic risk" is any risk that is at least "global" in scope, and is not subjectively "imperceptible" in intensity. Those that are at least "trans-generational" (affecting all future generations) in scope and "terminal"[clarification needed] in intensity are classified as existential risks. While a global catastrophic risk may kill the vast majority of life on earth, humanity could still potentially recover. An existential risk, on the other hand, is one that either destroys humanity (and, presumably, all but the most rudimentary species of non-human lifeforms and/or plant life) entirely or at least prevents any chance of civilization recovering. Bostrom considers existential risks to be far more significant.[6]

Similarly, in Catastrophe: Risk and Response, Richard Posner singles out and groups together events that bring about "utter overthrow or ruin" on a global, rather than a "local or regional" scale. Posner singles out such events as worthy of special attention on cost-benefit grounds because they could directly or indirectly jeopardize the survival of the human race as a whole.[7] Posner's events include meteor impacts, runaway global warming, grey goo, bioterrorism, and particle accelerator accidents.

Researchers experience difficulty in studying near human extinction directly, since humanity has never been destroyed before.[8] While this does not mean that it will not be in the future, it does make modelling existential risks difficult, due in part to survivorship bias.

Bostrom identifies four types of existential risk. "Bangs" are sudden catastrophes, which may be accidental or deliberate. He thinks the most likely sources of bangs are malicious use of nanotechnology, nuclear war, and the possibility that the universe is a simulation that will end. "Crunches" are scenarios in which humanity survives but civilization is slowly destroyed. The most likely causes of this, he believes, are exhaustion of natural resources, a stable global government that prevents technological progress, or dysgenic pressures that lower average intelligence. "Shrieks" are undesirable futures. For example, if a single mind enhances its powers by merging with a computer, it could dominate human civilization. Bostrom believes that this scenario is most likely, followed by flawed superintelligence and a repressive totalitarian regime. "Whimpers" are the gradual decline of human civilization or current values. He thinks the most likely cause would be evolution changing moral preference, followed by extraterrestrial invasion.[4]

Some risks, such as that from asteroid impact, with a one-in-a-million chance of causing humanity's extinction in the next century,[9] have had their probabilities predicted using straightforward, well-understood, and (in principle) precise methods (although even in cases like these, the exact rate of large impacts is contested).[10] Similarly, the frequency of volcanic eruptions of sufficient magnitude to cause catastrophic climate change, similar to the Toba Eruption, which may have almost caused the extinction of the human race,[11] has been estimated at about 1 in every 50,000 years.[12]

The relative danger posed by other threats is much more difficult to calculate. Given the limitations of ordinary calculation and modeling, expert elicitation is frequently used instead to obtain probability estimates.[13] In 2008, an informal survey of experts on different global catastrophic risks at the Global Catastrophic Risk Conference at the University of Oxford suggested a 19% chance of human extinction by the year 2100. The conference report cautions that the results should be taken "with a grain of salt".[14]

The 2016 annual report by the Global Challenges Foundation estimates that an average American is more than five times more likely to die during a human-extinction event than in a car crash.[15][16]

There are significant methodological challenges in estimating these risks with precision. Most attention has been given to risks to human civilization over the next 100 years, but forecasting for this length of time is difficult. The types of threats posed by nature may prove relatively constant, though new risks could be discovered. Anthropogenic threats, however, are likely to change dramatically with the development of new technology; while volcanoes have been a threat throughout history, nuclear weapons have only been an issue since the 20th century. Historically, the ability of experts to predict the future over these timescales has proved very limited. Man-made threats such as nuclear war or nanotechnology are harder to predict than natural threats, due to the inherent methodological difficulties in the social sciences. In general, it is hard to estimate the magnitude of the risk from this or other dangers, especially as both international relations and technology can change rapidly.

Existential risks pose unique challenges to prediction, even more than other long-term events, because of observation selection effects. Unlike with most events, the failure of a complete extinction event to occur in the past is not evidence against their likelihood in the future, because every world that has experienced such an extinction event has no observers, so regardless of their frequency, no civilization observes existential risks in its history.[8] These anthropic issues can be avoided by looking at evidence that does not have such selection effects, such as asteroid impact craters on the Moon, or directly evaluating the likely impact of new technology.[5]

In addition to known and tangible risks, unforeseeable black swan extinction events may occur, presenting an additional methodological problem.[17]

Some scholars have strongly favored reducing existential risk on the grounds that it greatly benefits future generations. Derek Parfit argues that extinction would be a great loss because our descendants could potentially survive for four billion years before the expansion of the Sun makes the Earth uninhabitable.[18][19] Nick Bostrom argues that there is even greater potential in colonizing space. If future humans colonize space, they may be able to support a very large number of people on other planets, potentially lasting for trillions of years.[6] Therefore, reducing existential risk by even a small amount would have a very significant impact on the expected number of people who will exist in the future.

Exponential discounting might make these future benefits much less significant. However, Jason Matheny has argued that such discounting is inappropriate when assessing the value of existential risk reduction.[9]

Some economists have discussed the importance of global catastrophic risks, though not existential risks. Martin Weitzman argues that most of the expected economic damage from climate change may come from the small chance that warming greatly exceeds the mid-range expectations, resulting in catastrophic damage.[20] Richard Posner has argued that we are doing far too little, in general, about small, hard-to-estimate risks of large-scale catastrophes.[21]

Numerous cognitive biases can influence people's judgment of the importance of existential risks, including scope insensitivity, hyperbolic discounting, availability heuristic, the conjunction fallacy, the affect heuristic, and the overconfidence effect.[22]

Scope insensitivity influences how bad people consider the extinction of the human race to be. For example, when people are motivated to donate money to altruistic causes, the quantity they are willing to give does not increase linearly with the magnitude of the issue: people are roughly as concerned about 200,000 birds getting stuck in oil as they are about 2,000.[23] Similarly, people are often more concerned about threats to individuals than to larger groups.[22]

There are economic reasons that can explain why so little effort is going into existential risk reduction. It is a global good, so even if a large nation decreases it, that nation will only enjoy a small fraction of the benefit of doing so. Furthermore, the vast majority of the benefits may be enjoyed by far future generations, and though these quadrillions of future people would in theory perhaps be willing to pay massive sums for existential risk reduction, no mechanism for such a transaction exists.[5]

Some sources of catastrophic risk are natural, such as meteor impacts or supervolcanoes. Some of these have caused mass extinctions in the past. On the other hand, some risks are man-made, such as global warming,[24] environmental degradation, engineered pandemics and nuclear war.

The Cambridge Project at Cambridge University states that the "greatest threats" to the human species are man-made; they are artificial intelligence, global warming, nuclear war, and rogue biotechnology.[25] The Future of Humanity Institute also states that human extinction is more likely to result from anthropogenic causes than natural causes.[5][26]

It has been suggested that learning computers that rapidly become superintelligent may take unforeseen actions, or that robots would out-compete humanity (one technological singularity scenario).[27] Because of its exceptional scheduling and organizational capability and the range of novel technologies it could develop, it is possible that the first Earth superintelligence to emerge could rapidly become matchless and unrivaled: conceivably it would be able to bring about almost any possible outcome, and be able to foil virtually any attempt that threatened to prevent it achieving its objectives.[28] It could eliminate, wiping out if it chose, any other challenging rival intellects; alternatively it might manipulate or persuade them to change their behavior towards its own interests, or it may merely obstruct their attempts at interference.[28] In Bostrom's book, Superintelligence: Paths, Dangers, Strategies, he defines this as the control problem.[29] Physicist Stephen Hawking, Microsoft founder Bill Gates and SpaceX founder Elon Musk have echoed these concerns, with Hawking theorizing that this could "spell the end of the human race".[30]

In 2009, the Association for the Advancement of Artificial Intelligence (AAAI) hosted a conference to discuss whether computers and robots might be able to acquire any sort of autonomy, and how much these abilities might pose a threat or hazard. They noted that some robots have acquired various forms of semi-autonomy, including being able to find power sources on their own and being able to independently choose targets to attack with weapons. They also noted that some computer viruses can evade elimination and have achieved "cockroach intelligence." They noted that self-awareness as depicted in science-fiction is probably unlikely, but that there were other potential hazards and pitfalls.[31] Various media sources and scientific groups have noted separate trends in differing areas which might together result in greater robotic functionalities and autonomy, and which pose some inherent concerns.[32][33]

A survey of AI experts estimated that the chance of human-level machine learning having an "extremely bad (e.g., human extinction)" long-term effect on humanity is 5%.[34] A survey by the Future of Humanity Institute estimated a 5% probability of extinction by superintelligence by 2100.[14] Eliezer Yudkowsky believes that risks from artificial intelligence are harder to predict than any other known risks due to bias from anthropomorphism. Since people base their judgments of artificial intelligence on their own experience, he claims that they underestimate the potential power of AI.[35]

Biotechnology can pose a global catastrophic risk in the form of bioengineered organisms (viruses, bacteria, fungi, plants or animals). In many cases the organism will be a pathogen of humans, livestock, crops or other organisms we depend upon (e.g. pollinators or gut bacteria). However, any organism able to catastrophically disrupt ecosystem functions, e.g. highly competitive weeds, outcompeting essential crops, poses a biotechnology risk.

A biotechnology catastrophe may be caused by accidentally releasing a genetically engineered organism escaping from controlled environments, by the planned release of such an organism which then turns out to have unforeseen and catastrophic interactions with essential natural or agro-ecosystems, or by intentional usage of biological agents in biological warfare, bioterrorism attacks.[36] Pathogens may be intentionally or unintentionally genetically modified to change virulence and other characteristics.[36] For example, a group of Australian researchers unintentionally changed characteristics of the mousepox virus while trying to develop a virus to sterilize rodents.[36] The modified virus became highly lethal even in vaccinated and naturally resistant mice.[37][38] The technological means to genetically modify virus characteristics are likely to become more widely available in the future if not properly regulated.[36]

Terrorist applications of biotechnology have historically been infrequent. To what extent this is due to a lack of capabilities or motivation is not resolved.[36] However, given current development, more risk from novel, engineered pathogens is to be expected in the future.[36] Exponential growth has been observed in the biotechnology sector, and Noun and Chyba predict that this will lead to major increases in biotechnological capabilities in the coming decades.[36] They argue that risks from biological warfare and bioterrorism are distinct from nuclear and chemical threats because biological pathogens are easier to mass-produce and their production is hard to control (especially as the technological capabilities are becoming available even to individual users).[36] A survey by the Future of Humanity Institute estimated a 2% probability of extinction from engineered pandemics by 2100.[14]

Noun and Chyba propose three categories of measures to reduce risks from biotechnology and natural pandemics: Regulation or prevention of potentially dangerous research, improved recognition of outbreaks and developing facilities to mitigate disease outbreaks (e.g. better and/or more widely distributed vaccines).[36]

Cyberattacks have the potential to destroy everything from personal data to electric grids. Christine Peterson, co-founder and past president of the Foresight Institute, believes a cyberattack on electric grids has the potential to be a catastrophic risk.[39]

Global warming refers to the warming caused by human technology since the 19th century or earlier. Projections of future climate change suggest further global warming, sea level rise, and an increase in the frequency and severity of some extreme weather events and weather-related disasters. Effects of global warming include loss of biodiversity, stresses to existing food-producing systems, increased spread of known infectious diseases such as malaria, and rapid mutation of microorganisms. In November 2017, a statement by 15,364 scientists from 184 countries indicated that increasing levels of greenhouse gases from use of fossil fuels, human population growth, deforestation, and overuse of land for agricultural production, particularly by farming ruminants for meat consumption, are trending in ways that forecast an increase in human misery over coming decades.[3]

An environmental or ecological disaster, such as world crop failure and collapse of ecosystem services, could be induced by the present trends of overpopulation, economic development,[40] and non-sustainable agriculture. Most environmental scenarios involve one or more of the following: Holocene extinction event,[41] scarcity of water that could lead to approximately one half of the Earth's population being without safe drinking water, pollinator decline, overfishing, massive deforestation, desertification, climate change, or massive water pollution episodes. Detected in the early 21st century, a threat in this direction is colony collapse disorder,[42] a phenomenon that might foreshadow the imminent extinction[43] of the Western honeybee. As the bee plays a vital role in pollination, its extinction would severely disrupt the food chain.

An October 2017 report published in The Lancet stated that toxic air, water, soils, and workplaces were collectively responsible for 9 million deaths worldwide in 2015, particularly from air pollution which was linked to deaths by increasing susceptibility to non-infectious diseases, such as heart disease, stroke, and lung cancer.[44] The report warned that the pollution crisis was exceeding "the envelope on the amount of pollution the Earth can carry" and threatens the continuing survival of human societies.[44]

Romanian American economist Nicholas Georgescu-Roegen, a progenitor in economics and the paradigm founder of ecological economics, has argued that the carrying capacity of Earth that is, Earth's capacity to sustain human populations and consumption levels is bound to decrease sometime in the future as Earth's finite stock of mineral resources is presently being extracted and put to use; and consequently, that the world economy as a whole is heading towards an inevitable future collapse, leading to the demise of human civilization itself.[45]:303f Ecological economist and steady-state theorist Herman Daly, a student of Georgescu-Roegen, has propounded the same argument by asserting that "... all we can do is to avoid wasting the limited capacity of creation to support present and future life [on Earth]."[46]:370

Ever since Georgescu-Roegen and Daly published these views, various scholars in the field have been discussing the existential impossibility of allocating earth's finite stock of mineral resources evenly among an unknown number of present and future generations. This number of generations is likely to remain unknown to us, as there is no way or only little way of knowing in advance if or when mankind will ultimately face extinction. In effect, any conceivable intertemporal allocation of the stock will inevitably end up with universal economic decline at some future point.[47]:253256 [48]:165 [49]:168171 [50]:150153 [51]:106109 [52]:546549 [53]:142145

Nick Bostrom suggested that in the pursuit of knowledge, humanity might inadvertently create a device that could destroy Earth and the Solar System.[54] Investigations in nuclear and high-energy physics could create unusual conditions with catastrophic consequences. For example, scientists worried that the first nuclear test might ignite the atmosphere.[55][56] More recently, others worried that the RHIC[57] or the Large Hadron Collider might start a chain-reaction global disaster involving black holes, strangelets, or false vacuum states. These particular concerns have been refuted,[58][59][60][61] but the general concern remains.

Biotechnology could lead to the creation of a pandemic, chemical warfare could be taken to an extreme, nanotechnology could lead to grey goo in which out-of-control self-replicating robots consume all living matter on earth while building more of themselvesin both cases, either deliberately or by accident.[62]

Many nanoscale technologies are in development or currently in use.[63] The only one that appears to pose a significant global catastrophic risk is molecular manufacturing, a technique that would make it possible to build complex structures at atomic precision.[64] Molecular manufacturing requires significant advances in nanotechnology, but once achieved could produce highly advanced products at low costs and in large quantities in nanofactories of desktop proportions.[63][64] When nanofactories gain the ability to produce other nanofactories, production may only be limited by relatively abundant factors such as input materials, energy and software.[63]

Molecular manufacturing could be used to cheaply produce, among many other products, highly advanced, durable weapons.[63] Being equipped with compact computers and motors these could be increasingly autonomous and have a large range of capabilities.[63]

Chris Phoenix and Treder classify catastrophic risks posed by nanotechnology into three categories:

Several researchers state that the bulk of risk from nanotechnology comes from the potential to lead to war, arms races and destructive global government.[37][63][65] Several reasons have been suggested why the availability of nanotech weaponry may with significant likelihood lead to unstable arms races (compared to e.g. nuclear arms races):

Since self-regulation by all state and non-state actors seems hard to achieve,[67] measures to mitigate war-related risks have mainly been proposed in the area of international cooperation.[63][68] International infrastructure may be expanded giving more sovereignty to the international level. This could help coordinate efforts for arms control. International institutions dedicated specifically to nanotechnology (perhaps analogously to the International Atomic Energy Agency IAEA) or general arms control may also be designed.[68] One may also jointly make differential technological progress on defensive technologies, a policy that players should usually favour.[63] The Center for Responsible Nanotechnology also suggests some technical restrictions.[69] Improved transparency regarding technological capabilities may be another important facilitator for arms-control.

Grey goo is another catastrophic scenario, which was proposed by Eric Drexler in his 1986 book Engines of Creation[70] and has been a theme in mainstream media and fiction.[71][72] This scenario involves tiny self-replicating robots that consume the entire biosphere using it as a source of energy and building blocks. Nowadays, however, nanotech expertsincluding Drexlerdiscredit the scenario. According to Phoenix, a "so-called grey goo could only be the product of a deliberate and difficult engineering process, not an accident".[73]

The scenarios that have been explored most frequently are nuclear warfare and doomsday devices. Although the probability of a nuclear war per year is slim, Professor Martin Hellman has described it as inevitable in the long run; unless the probability approaches zero, inevitably there will come a day when civilization's luck runs out.[74] During the Cuban missile crisis, U.S. president John F. Kennedy estimated the odds of nuclear war at "somewhere between one out of three and even".[75] The United States and Russia have a combined arsenal of 14,700 nuclear weapons,[76] and there is an estimated total of 15,700 nuclear weapons in existence worldwide.[76] Beyond nuclear, other military threats to humanity include biological warfare (BW). By contrast, chemical warfare, while able to create multiple local catastrophes, is unlikely to create a global one.

Nuclear war could yield unprecedented human death tolls and habitat destruction. Detonating large numbers of nuclear weapons would have an immediate, short term and long-term effects on the climate, causing cold weather and reduced sunlight and photosynthesis[77] that may generate significant upheaval in advanced civilizations.[78] However, while popular perception sometimes takes nuclear war as "the end of the world", experts assign low probability to human extinction from nuclear war.[79][80] In 1982, Brian Martin estimated that a USSoviet nuclear exchange might kill 400450 million directly, mostly in the United States, Europe and Russia, and maybe several hundred million more through follow-up consequences in those same areas.[79] A survey by the Future of Humanity Institute estimated a 4% probability of extinction from warfare by 2100, with a 1% chance of extinction from nuclear warfare.[14]

The 20th century saw a rapid increase in human population due to medical developments and massive increases in agricultural productivity[81] such as the Green Revolution.[82] Between 1950 and 1984, as the Green Revolution transformed agriculture around the globe, world grain production increased by 250%. The Green Revolution in agriculture helped food production to keep pace with worldwide population growth or actually enabled population growth. The energy for the Green Revolution was provided by fossil fuels in the form of fertilizers (natural gas), pesticides (oil), and hydrocarbon-fueled irrigation.[83] David Pimentel, professor of ecology and agriculture at Cornell University, and Mario Giampietro, senior researcher at the National Research Institute on Food and Nutrition (INRAN), place in their 1994 study Food, Land, Population and the U.S. Economy the maximum U.S. population for a sustainable economy at 200 million. To achieve a sustainable economy and avert disaster, the United States must reduce its population by at least one-third, and world population will have to be reduced by two-thirds, says the study.[84]

The authors of this study believe that the mentioned agricultural crisis will begin to have an effect on the world after 2020, and will become critical after 2050. Geologist Dale Allen Pfeiffer claims that coming decades could see spiraling food prices without relief and massive starvation on a global level such as never experienced before.[85][86]

Wheat is humanity's third-most-produced cereal. Extant fungal infections such as Ug99[87] (a kind of stem rust) can cause 100% crop losses in most modern varieties. Little or no treatment is possible and infection spreads on the wind. Should the world's large grain-producing areas become infected, the ensuing crisis in wheat availability would lead to price spikes and shortages in other food products.[88]

Several asteroids have collided with earth in recent geological history. The Chicxulub asteroid, for example, is theorized to have caused the extinction of the non-avian dinosaurs 66 million years ago at the end of the Cretaceous. No sufficiently large asteroid currently exists in an Earth-crossing orbit; however, a comet of sufficient size to cause human extinction could impact the Earth, though the annual probability may be less than 108.[89] Geoscientist Brian Toon estimates that a 60-mile meteorite would be large enough to "incinerate everybody".[90] Asteroids with around a 1km diameter have impacted the Earth on average once every 500,000 years; these are probably too small to pose an extinction risk, but might kill billions of people.[89][91] Larger asteroids are less common. Small near-Earth asteroids are regularly observed and can impact anywhere on the Earth injuring local populations [92]. As of 2013, Spaceguard estimates it has identified 95% of all NEOs over 1km in size.[93]

In April 2018, the B612 Foundation reported "It's a 100 per cent certain we'll be hit [by a devastating asteroid], but we're not 100 per cent sure when."[94][95] In June 2018, the US National Science and Technology Council warned that America is unprepared for an asteroid impact event, and has developed and released the "National Near-Earth Object Preparedness Strategy Action Plan" to better prepare.[96][97][98][99][100]

Extraterrestrial life could invade Earth[101] either to exterminate and supplant human life, enslave it under a colonial system, steal the planet's resources, or destroy the planet altogether.

Although evidence of alien life has never been documented, scientists such as Carl Sagan have postulated that the existence of extraterrestrial life is very likely. In 1969, the "Extra-Terrestrial Exposure Law" was added to the United States Code of Federal Regulations (Title 14, Section 1211) in response to the possibility of biological contamination resulting from the U.S. Apollo Space Program. It was removed in 1991.[102] Scientists consider such a scenario technically possible, but unlikely.[103]

An article in The New York Times discussed the possible threats for humanity of intentionally sending messages aimed at extraterrestrial life into the cosmos in the context of the SETI efforts. Several renowned public figures such as Stephen Hawking and Elon Musk have argued against sending such messages on the grounds that extraterrestrial civilizations with technology are probably far more advanced than humanity and could pose an existential threat to humanity.[104]

Climate change refers to a lasting change in the Earth's climate. The climate has ranged from ice ages to warmer periods when palm trees grew in Antarctica. It has been hypothesized that there was also a period called "snowball Earth" when all the oceans were covered in a layer of ice. These global climatic changes occurred slowly, prior to the rise of human civilization about 10 thousand years ago near the end of the last Major Ice Age when the climate became more stable. However, abrupt climate change on the decade time scale has occurred regionally. Since civilization originated during a period of stable climate, a natural variation into a new climate regime (colder or hotter) could pose a threat to civilization.

In the history of the Earth, many ice ages are known to have occurred. More ice ages will be possible at an interval of 40,000100,000 years. An ice age would have a serious impact on civilization because vast areas of land (mainly in North America, Europe, and Asia) could become uninhabitable. It would still be possible to live in the tropical regions, but with possible loss of humidity and water. Currently, the world is in an interglacial period within a much older glacial event. The last glacial expansion ended about 10,000 years ago, and all civilizations evolved later than this. Scientists do not predict that a natural ice age will occur anytime soon. This may be due to manmade emissions potentially delaying the possible onset or another ice age for at least another 50,000 years.

A number of astronomical threats have been identified. Massive objects, e.g. a star, large planet or black hole, could be catastrophic if a close encounter occurred in the Solar System. In April 2008, it was announced that two simulations of long-term planetary movement, one at the Paris Observatory and the other at the University of California, Santa Cruz, indicate a 1% chance that Mercury's orbit could be made unstable by Jupiter's gravitational pull sometime during the lifespan of the Sun. Were this to happen, the simulations suggest a collision with Earth could be one of four possible outcomes (the others being Mercury colliding with the Sun, colliding with Venus, or being ejected from the Solar System altogether). If Mercury were to collide with Earth, all life on Earth could be obliterated entirely: an asteroid 15km wide is believed to have caused the extinction of the non-avian dinosaurs, whereas Mercury is 4,879km in diameter.[105]

Another cosmic threat is a gamma-ray burst, typically produced by a supernova when a star collapses inward on itself and then "bounces" outward in a massive explosion. Under certain circumstances, these events are thought to produce massive bursts of gamma radiation emanating outward from the axis of rotation of the star. If such an event were to occur oriented towards the Earth, the massive amounts of gamma radiation could significantly affect the Earth's atmosphere and pose an existential threat to all life. Such a gamma-ray burst may have been the cause of the OrdovicianSilurian extinction events. Neither this scenario nor the destabilization of Mercury's orbit are likely in the foreseeable future.[106]

If the Solar System were to pass through a dark nebula, a cloud of cosmic dust, severe global climate change would occur.[107]

A powerful solar flare or solar superstorm, which is a drastic and unusual decrease or increase in the Sun's power output, could have severe consequences for life on Earth.[citation needed]

If our universe lies within a false vacuum, a bubble of lower-energy vacuum could come to exist by chance or otherwise in our universe, and catalyze the conversion of our universe to a lower energy state in a volume expanding at nearly the speed of light, destroying all that we know without forewarning.[108][further explanation needed] Such an occurrence is called vacuum decay.

The magnetic poles of the Earth shifted many times in geologic history. The duration of such a shift is still debated. Theories exist that during such times, the Earth's magnetic field would be substantially weakened, threatening civilization by allowing radiation from the Sun, especially solar wind, solar flares or cosmic radiation, to reach the surface. These theories have been somewhat discredited, as statistical analysis shows no evidence for a correlation between past reversals and past extinctions.[109][110]

Numerous historical examples of pandemics[111] had a devastating effect on a large number of people. The present, unprecedented scale and speed of human movement make it more difficult than ever to contain an epidemic through local quarantines. A global pandemic has become a realistic threat to human civilization.

Naturally evolving pathogens will ultimately develop an upper limit to their virulence.[112] Pathogens with the highest virulence, quickly killing their hosts reduce their chances of spread the infection to new hosts or carriers.[113] This simple model predicts that - if virulence and transmission are not genetically linked - pathogens will evolve towards low virulence and rapid transmission. However, this is not necessarily a safeguard against a global catastrophe, for the following reasons:

1. The fitness advantage of limited virulence is primarily a function of a limited number of hosts. Any pathogen with a high virulence, high transmission rate and long incubation time may have already caused a catastrophic pandemic before ultimately virulence is limited through natural selection.2. In models where virulence level and rate of transmission are related, high levels of virulence can evolve.[114] Virulence is instead limited by the existence of complex populations of hosts with different susceptibilities to infection, or by some hosts being geographically isolated.[112] The size of the host population and competition between different strains of pathogens can also alter virulence.[115] 3. A pathogen that infects humans as a secondary host and primarily infects another species (a zoonosis) has no constraints on its virulence in people, since the accidental secondary infections do not affect its evolution.[116]

A geological event such as massive flood basalt, volcanism, or the eruption of a supervolcano[117] could lead to a so-called volcanic winter, similar to a nuclear winter. One such event, the Toba eruption,[118] occurred in Indonesia about 71,500 years ago. According to the Toba catastrophe theory,[119] the event may have reduced human populations to only a few tens of thousands of individuals. Yellowstone Caldera is another such supervolcano, having undergone 142 or more caldera-forming eruptions in the past 17 million years.[120]A massive volcano eruption would eject extraordinary volumes of volcanic dust, toxic and greenhouse gases into the atmosphere with serious effects on global climate (towards extreme global cooling: volcanic winter if short-term, and ice age if long-term) or global warming (if greenhouse gases were to prevail).

When the supervolcano at Yellowstone last erupted 640,000 years ago, the thinnest layers of the ash ejected from the caldera spread over most of the United States west of the Mississippi River and part of northeastern Mexico. The magma covered much of what is now Yellowstone National Park and extended beyond, covering much of the ground from Yellowstone River in the east to the Idaho falls in the west, with some of the flows extending north beyond Mammoth Springs.[121]

According to a recent study, if the Yellowstone caldera erupted again as a supervolcano, an ash layer one to three millimeters thick could be deposited as far away as New York, enough to "reduce traction on roads and runways, short out electrical transformers and cause respiratory problems". There would be centimeters of thickness over much of the U.S. Midwest, enough to disrupt crops and livestock, especially if it happened at a critical time in the growing season. The worst-affected city would likely be Billings, Montana, population 109,000, which the model predicted would be covered with ash estimated as 1.03 to 1.8 meters thick.[122]

The main long-term effect is through global climate change, which reduces the temperature globally by about 515 degrees C for a decade, together with the direct effects of the deposits of ash on their crops. A large supervolcano like Toba would deposit one or two meters thickness of ash over an area of several million square kilometers.(1000 cubic kilometers is equivalent to a one-meter thickness of ash spread over a million square kilometers). If that happened in some densely populated agricultural area, such as India, it could destroy one or two seasons of crops for two billion people.[123]

However, Yellowstone shows no signs of a supereruption at present, and it is not certain that a future supereruption will occur there.[124][125]

Research published in 2011 finds evidence that massive volcanic eruptions caused massive coal combustion, supporting models for significant generation of greenhouse gases. Researchers have suggested that massive volcanic eruptions through coal beds in Siberia would generate significant greenhouse gases and cause a runaway greenhouse effect.[126] Massive eruptions can also throw enough pyroclastic debris and other material into the atmosphere to partially block out the sun and cause a volcanic winter, as happened on a smaller scale in 1816 following the eruption of Mount Tambora, the so-called Year Without a Summer. Such an eruption might cause the immediate deaths of millions of people several hundred miles from the eruption, and perhaps billions of deaths[127] worldwide, due to the failure of the monsoon[citation needed], resulting in major crop failures causing starvation on a profound scale.[127]

A much more speculative concept is the verneshot: a hypothetical volcanic eruption caused by the buildup of gas deep underneath a craton. Such an event may be forceful enough to launch an extreme amount of material from the crust and mantle into a sub-orbital trajectory.

Planetary management and respecting planetary boundaries have been proposed as approaches to preventing ecological catastrophes. Within the scope of these approaches, the field of geoengineering encompasses the deliberate large-scale engineering and manipulation of the planetary environment to combat or counteract anthropogenic changes in atmospheric chemistry. Space colonization is a proposed alternative to improve the odds of surviving an extinction scenario.[128] Solutions of this scope may require megascale engineering.Food storage has been proposed globally, but the monetary cost would be high. Furthermore, it would likely contribute to the current millions of deaths per year due to malnutrition.[citation needed]

Some survivalists stock survival retreats with multiple-year food supplies.

The Svalbard Global Seed Vault is buried 400 feet (120m) inside a mountain on an island in the Arctic. It is designed to hold 2.5 billion seeds from more than 100 countries as a precaution to preserve the world's crops. The surrounding rock is 6C (21F) (as of 2015) but the vault is kept at 18C (0F) by refrigerators powered by locally sourced coal.[129][130]

More speculatively, if society continues to function and if the biosphere remains habitable, calorie needs for the present human population might in theory be met during an extended absence of sunlight, given sufficient advance planning. Conjectured solutions include growing mushrooms on the dead plant biomass left in the wake of the catastrophe, converting cellulose to sugar, or feeding natural gas to methane-digesting bacteria.[131][132]

Insufficient global governance creates risks in the social and political domain, but the governance mechanisms develop more slowly than technological and social change. There are concerns from governments, the private sector, as well as the general public about the lack of governance mechanisms to efficiently deal with risks, negotiate and adjudicate between diverse and conflicting interests. This is further underlined by an understanding of the interconnectedness of global systemic risks.[133]

The Bulletin of the Atomic Scientists (est. 1945) is one of the oldest global risk organizations, founded after the public became alarmed by the potential of atomic warfare in the aftermath of WWII. It studies risks associated with nuclear war and energy and famously maintains the Doomsday Clock established in 1947. The Foresight Institute (est. 1986) examines the risks of nanotechnology and its benefits. It was one of the earliest organizations to study the unintended consequences of otherwise harmless technology gone haywire at a global scale. It was founded by K. Eric Drexler who postulated "grey goo".[134][135]

Beginning after 2000, a growing number of scientists, philosophers and tech billionaires created organizations devoted to studying global risks both inside and outside of academia.[136]

Independent non-governmental organizations (NGOs) include the Machine Intelligence Research Institute, which aims to reduce the risk of a catastrophe caused by artificial intelligence,[137] with donors including Peter Thiel and Jed McCaleb.[138] The Lifeboat Foundation (est. 2009) funds research into preventing a technological catastrophe.[139] Most of the research money funds projects at universities.[140] The Global Catastrophic Risk Institute (est. 2011) is a think tank for catastrophic risk. It is funded by the NGO Social and Environmental Entrepreneurs. The Global Challenges Foundation (est. 2012), based in Stockholm and founded by Laszlo Szombatfalvy, releases a yearly report on the state of global risks.[15][16] The Future of Life Institute (est. 2014) aims to support research and initiatives for safeguarding life considering new technologies and challenges facing humanity.[141] Elon Musk is one of its biggest donors.[142] The Nuclear Threat Initiative seeks to reduce global threats from nuclear, biological and chemical threats, and containment of damage after an event.[143] It maintains a nuclear material security index.[144]

University-based organizations include the Future of Humanity Institute (est. 2005) which researches the questions of humanity's long-term future, particularly existential risk. It was founded by Nick Bostrom and is based at Oxford University. The Centre for the Study of Existential Risk (est. 2012) is a Cambridge-based organization which studies four major technological risks: artificial intelligence, biotechnology, global warming and warfare. All are man-made risks, as Huw Price explained to the AFP news agency, "It seems a reasonable prediction that some time in this or the next century intelligence will escape from the constraints of biology". He added that when this happens "we're no longer the smartest things around," and will risk being at the mercy of "machines that are not malicious, but machines whose interests don't include us."[145] Stephen Hawking was an acting adviser. The Millennium Alliance for Humanity and the Biosphere is a Stanford University-based organization focusing on many issues related to global catastrophe by bringing together members of academic in the humanities.[146][147] It was founded by Paul Ehrlich among others.[148] Stanford University also has the Center for International Security and Cooperation focusing on political cooperation to reduce global catastrophic risk.[149]

Other risk assessment groups are based in or are part of governmental organizations. The World Health Organization (WHO) includes a division called the Global Alert and Response (GAR) which monitors and responds to global epidemic crisis.[150] GAR helps member states with training and coordination of response to epidemics.[151] The United States Agency for International Development (USAID) has its Emerging Pandemic Threats Program which aims to prevent and contain naturally generated pandemics at their source.[152] The Lawrence Livermore National Laboratory has a division called the Global Security Principal Directorate which researches on behalf of the government issues such as bio-security and counter-terrorism.[153]

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Stem Cell Treatment/Therapy COST in India| DheerajBojwani.Com

Posted: September 26, 2018 at 2:46 pm

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Stem Cell treatment is an intricate process. Stem Cell transplant patients need utmost care with respect to both emotionally and physically. Dheeraj Bojwani Consultants is a prominent medical tourism company in India making world-class medical facilities from best surgeons and hospitals accessible for international patients looking for budget-friendly treatment abroad.

Mrs. Marilyn Obiora - Nigeria Stem Cell Therapy For her Daughter in India

Hi, my name is Mrs. Marilyn Obiora, and I am from Nigeria. I came to India for my daughter's Stem Cell Therapy in India. My daughter had her first stroke in 2011. She couldn't sit, talk and had lost control of her neck. We could not find suitable help for her condition and searched for treatment in India.

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Medical science has come a long way since its practice began thousands of years ago. Scientists are finding superior and more resourceful ways to cure diseases of different organs. Stem cells are undifferentiated parent cells that can transform into specialized cell types, divide further and produce more stem cells of the same group. Stem Cell therapy is performed to prevent or treat a health condition. Stem Cell Treatment is a reproductive therapy where nourishing tissues reinstate damaged tissues for relief from incurable diseases. Stem cell treatment is one of the approaches with a potential to heal a wide range of diseases in the near future. Science has always provided ground-breaking answers to obdurate health conditions, but the latest medical miracle that the medical fraternity has gifted to mankind is the Stem Cell Therapy.

Stem cell therapy is an array of techniques intended to replace cells damaged or destroyed by disease with healthy functioning ones. Even though the techniques are relatively new, their applications and advantages are broad and surprising the medical world with every new research. Stem cells are obtained from bone marrow or human umbilical cord. They are also known as the fundamental cells of our body and have the power to develop into any type of tissue cell in the body. Stem cell treatment is based on the principle that the cells move to the site of injury and transform themselves to form new tissue cells to replace the damaged ones. They have the capacity to proliferate and renew themselves indefinitely and can form mature muscle cells, nerve cells, and blood cells. In this type of therapy, they are derived from the body, kept under artificial conditions where they mature into the type of cells that are required to heal a certain part of the body or disease.

Stem cells are being studied and used to treat different types of cancers, disorders related to the blood, immune disorders, and metabolic disorders. Some other diseases and health conditions that may be healed using stem cell treatment are,

Recently, a team of researchers successfully secured the peripheral nerves in the upper arms of a patient suffering peripheral nerve damage, by using skin-derived stem cells (SDSCs) and a previously developed collagen tube, premeditated to successfully bridge gaps in injured nerves.

A research has found potential in bone marrow stem cell therapy to treat TB. Patients injected with new mesenchymal stromal cells derived from their own bone marrow showed positive response against the TB bacteria. The therapy also didnt show any serious adverse effects.

Stem cells are also used to treat hair loss. A small amount of fat is taken from the waist area of the patient by a mini-liposuction process. This fat contains dormant stem cells, and is then spun to separate the stem cells from the fat. An activation solution is added to the cells, and may be multiplied in number, depending on the size of the bald area. Once activated, the solution is washed off so that only cells remain. Now, the stem cells are injected into the scalp. One can find some hair growth in about two to four weeks.

Damaged cones in retinas can be regenerated and eyesight restored through stem cell. Stem cell therapy could regenerate damaged cones in people, especially in the cone-rich regions of the retina that provide daytime/color vision.

Kidney transplants have become more common and easier thanks stem cell therapy. Normally patients who undergo organ transplants need a lifetime of costly anti-rejection drugs but the new procedure may negate this need, with organ donors stem cells. Unless there is a perfect match donor, patients have to wait long for an organ transplant. Though still in early stages, the stem cell research is being considered as a potential player in the field of transplantation.

Transplanted stem cells serve as migratory signals for the brain's own neurogenic cells, guiding the new host cells towards the injured brain tissue. Stem cells have the potential to give rise to many different cell types that carry out different functions. While the stem cells in adult bone marrow tend to develop into the cells that make up the organ system from which they originated. These multipotent stem cells can be manipulated to take up the characteristics of neural cells.

Experts are using Stem cell Transplant to treat the symptoms of spinal cord injury by transplantation of cells directly into the gray matter of the patients spinal cord. Expectedly, the cells will integrate into the patients own neural tissue and create new circuitry to help transmit nerve signals to muscles. The transplanted cells may also promote reorganization of the spinal cord segmental circuitry, possibly leading to improved motor function.

Stem cells are capable of differentiating into a variety of different cell types, and if the architecture of damaged tendon is restored, it would improve the management of patients with these injuries significantly.

A promising benefit of stem cell therapy is its potential for cardiac tissue regeneration to reverse tissue loss underlying the development of heart failure after cardiac injury. Possible mechanisms of recovery include generation of heart muscle cells, stimulation of new blood vessels growth, secretion of growth factors.

It is a complex and multifarious procedure, with several risks and complications involved and is thus recommended to a few patients when other treatments have failed. Stem Cell therapy is recommended when other treatments fail to give positive results. The best candidates for Stem cell Treatment are those in good health and have stem cells available from a sibling, or any other family member.

India has been recognized as the new medical destination for Stem Cell therapies. Hundreds of international patients from around the world visit to India for high quality medical care at par with developed nations like the US, UK, at the most affordable costs.

The Hospitals in India have the most extensive diagnostic and imaging facilities including Asias most advanced MRI and CT technology. India provides services of the most leading doctors and Stem Cell Therapy professionals at reasonable cost budget in the following cities :

Ms. Olu Adegbenro from Nigeria

Thanks to Dheeraj Bojwani Group for today I can live a happy life. Three years ago, I was diagnosed with optical atrophy due to advanced staged of Glaucoma. Eventually it turned up to as stage where my vision was completely impaired. Then, when I connected with the Dheeraj Bojwani Group after lots of research, evaluation, judgments and discussion, a specialist from the group suggested stem cell therapy. Today its been five years after the Therapy and I am extremely happy with the results of my stem cell treatment in India as my vision has improved a lot post treatment.

India offers outstanding Stem Cell Treatment at cost far below that prevailing in USA or other Western countries. Even with travel expenses taken into account, the comprehensive medical tourism packages still provide a savings measured in the thousands of dollars for major procedures. A cost comparison can give you the exact idea about the difference which shows the low cost stem cell treatment in India :

There are many reasons for India becoming a popular medical tourism spot is the low cost stem cell treatment in the area. When in contrast to the first world countries like, US and UK, medical care in India costs as much as 60-90% lesser, that makes it a great option for the citizens of those countries to opt for stem cell treatment in India because of availability of top stem cell treatment clinics in India, affordable prices strategic connectivity, food, zero language barrier and many other reasons.

The maximum number of patients for Stem Cell Treatment comes from Nigeria, Kenya, Ethiopia, USA, UK, Australia, Saudi Arabia, UAE, Uzbekistan, Bangladesh

Below are the downloadable links that will help you to plan your medical trip to India in a more organized and better way. Attached word and pdf files gives information that will help you to know India more and make your trip to India easy and memorable one.

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Stem Cell Treatment/Therapy COST in India| DheerajBojwani.Com

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Stem Cell Ruidoso New Mexico 88345

Posted: September 26, 2018 at 2:44 pm

Stem cell therapy has ended up being a popular argument in the international medical scene. This highly controversial therapy has actually received combined opinions from numerous stakeholders in the health care industry and has actually also attracted the interest of political leaders, spiritual leaders and the basic population at large. Stem cell treatment is thought about an advanced treatment for people suffering from a large range of degenerative conditions. Some typical concerns regarding this treatment are addressed below.

Are you a stem cell therapy provider close to Ruidoso NM 88345? Contact us for more information about joining our website.

Stem cells can be referred to as blank state or non-specialized cells that have the ability to become specialized cells in the body such as bone, muscle, nerve or organ cells. This indicates that these unique cells can be used to regrow or develop a wide variety of damaged cells and tissues in the body. Stem cell therapy is for that reason a treatment that focuses on attaining tissue regrowth and can be utilized to treat health conditions and illnesses such as osteoarthritis, degenerative disc disease, spine injury, muscular degeneration, motor neuron illness, ALS, Parkinsons, cardiovascular disease and much more.

Being a treatment that is still under research, stem cell therapy has not been totally accepted as a practical treatment option for the above pointed out health conditions and illnesses. A lot of research study is currently being carried out by scientists and medical professionals in different parts of the world to make this treatment practical and efficient. There are nevertheless numerous limitations imposed by governments on research study involving embryonic stem cells.

Currently, there have not been numerous case studies carried out for this form of treatment. Nevertheless, with the few case studies that have actually been conducted, among the significant issues that has been raised is the increase in a clients danger of establishing cancer. Cancer is triggered by the quick multiplication of cells that tend not to die so quickly. Stem cells have been connected with comparable growth aspects that may cause formation of growths and other cancerous cells in clients.

Contact us for more information about stem cell therapy in Ruidoso NM 88345

Stem cells can be drawn out from a young embryo after conception. These stem cells are typically referred to as embryonic stem cells. After the stem cells are extracted from the embryo, the embryo is terminated. This is essentially one of the major reasons for debate in the field of stem cell studio. Lots of people say that termination of an embryo is unethical and undesirable.

Stem cells can still be acquired through other means as they can be discovered in the blood, bone marrow and umbilical cables of adult humans. Regular body cells can also be reverse-engineered to become stem cells that have restricted capabilities.

New studio has nevertheless shown promise as scientists target at developing stem cells that do not form into growths in later treatment phases. These stem cells can for that reason effectively transform into other kinds of specialized cells. This treatment is for that reason worth researching into as numerous clients can gain from this innovative treatment.

Find a stem cell provider close to Ruidoso NM 88345

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Main address:Ruidoso, New Mexico, 88345

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Stem Cell Ruidoso New Mexico 88345

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