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Genetics | Children’s Hospital of Pittsburgh

Posted: August 2, 2018 at 11:43 am

The Division of Medical Genetics at UPMC Children's Hospital of Pittsburgh is committed to the treatment and study of genetic disorders in children, providing advanced patient care of the highest quality and an active research program dedicated to providing a deeper understanding of the fundamental issues underlying these disorders and developing better therapeutic approaches.

Clinical services, a critical part of the comprehensive care offered by the Division of Medical Genetics, include diagnosis, evaluation, treatment and management of a range of genetic conditions, such as birth defects, chromosomal abnormalities, specific genetic syndromes and inborn errors of metabolism. These services are organized under two programs:an Inborn Errors of Metabolism Clinic and a General Genetics Clinic. Both offer an experienced team of faculty and staff, including physician geneticists, genetic counselors, a nurse practitioner, metabolic dietitian and social worker.

The Inborn Errors of Metabolism Clinic at Childrens Hospital provides diagnostic services, evaluation, treatment management, genetic counseling and other support to children with these inherited disorders and to their families. A Phenylketonuria Clinic specializes in the diagnosis, treatment and management of one of the most common inborn errors of metabolism.

Counseling, education and other support services to address all of the needs of patients and their families are also provided. Genetic counselors are available to help to identify families at risk, serve as patient advocates, help families understand genetic disorders and their consequences, provide supportive counseling and counsel families who may be at risk for inherited conditions. Division staff members also help families arrange for physical, occupational and speech therapists, comprehensive developmental assessments and other services and support.

Research within the division is providing new insight into genetic disorders from which new and better therapies can be developed. The laboratory research program focuses on discovering the underlying causes of genetic diseases, understanding the clinical implications of mutations in genes, and development of novel approaches for treatment of genetic disorders. An active clinical research program collaborates with other genetic programs world wide to evaluate new therapies for genetic disease.

Referrals from primary care physicians, medical and social agencies or other Childrens Hospital specialty services are helpful, but not necessary. Authorization from the patients insurance provider and/or primary care physician may be needed for insurance coverage. The Division of Medical Genetics staff can help with these matters. Medical records from previous medical evaluations may be requested. For more information, please call the office number listed.

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Genetics | Answers in Genesis

Posted: August 2, 2018 at 11:43 am

Scientists have discovered an unmistakable language within all living things. Like a miniature library, DNA stores piles of information in extraordinary molecules that specify the details of everything from the shape of flower petals to the color of your eyes. A supremely intelligent Author and Life-Giver left His indelible message in every living thing.

The species on earth today descend from the original created kinds of Genesis 1. The many inter-species breedings that are possible today (e.g., zonkeys, wholphins), as well as the close similarities within biological groups (e.g., the canine group) that are distinct from one another, remind us of this fact. But exactly why the created kinds have fractured into many incompatible species has only been answered indirectly by creationists.

Successful evolution requires the addition of new information and new genes that produce new proteins that are found in new organs and systems. Losing structures, or misplacing their development, should not be equated with the increased information that is needed to form novel structures and cellular systems.

Minimal genomes is the number of genes considered essential for a bacterium to survive in a nutrient-rich, stress-free and competitor-free environment in the lab. Evolutionists believe if the genes universal to all life can be determined then its just a matter of tinkering with the existing genetic information via mutations to go from goo to you.

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Knee Stem Cell Treatments in Kansas City | Motus Biologics

Posted: August 2, 2018 at 11:41 am

stem cell treatments

Is knee arthritis or a meniscus tear keeping you from doing the things you love?

Knees are the most commonly replaced joints. The knee is a large hinged joint that is comprised of the lower end of the thighbone (femur), the upper end of the shinbone (tibia), and the underside of the kneecap (patella). These bones are covered in cartilage which can wear down over time from activity and genetics (osteoarthritis), autoimmune illnesses (i.e. rheumatoid arthritis), or trauma (fractures, previous surgeries, or old sports injuries). More often than not, patients will have chronic (also known as degenerative) tears to the meniscus or shock absorbers due to arthritis.

What do my symptoms mean? Do I need surgery?

Regardless of the cause of knee arthritis, symptoms tend to be similar and consist of pain with activities such as squatting, pivoting, walking on uneven surfaces and up and down stairs. The pain is often associated with stiffness and can interfere with sleep. Some patients may even notice a change in their leg which may appear more bow-legged or knock-kneed. Routine conservative treatment options have included rest, activity modification, weight loss, anti-inflammatory medications, viscosupplementation (i.e. Synvisc and Euflexxa), and steroid injections. When these therapies no longer provide pain relief, patients are oftentimes referred for arthroscopic surgery (to clean out arthritis and torn meniscus) or for total knee replacement.

Knee replacement is an invasive surgery and carries significant risks such as bleeding, infection, blood clots, and, infrequently, heart attack or stroke. There is a lengthy and painful recovery period that requires time off of work for most individuals.

The American Academy of Family Physicians (May 1, 2015, Volume 91, Number 9), found there is emerging evidence showing that arthroscopic knee surgeries involving the clean out of degenerative meniscus tears, also known as partial meniscectomy, show no long-term benefit in middle-aged people.

Surgery involves removing the damaged bone and cartilage and replacing these with a prosthesis consisting of metal and a plastic spacer. This spacer acts as a smooth gliding surface. Unfortunately, every plastic spacer begins to wear and, occasionally, loosen with normal use and activity. This can be accelerated with being overweight or partaking in high-impact activities such as running, jogging, or jumping. These activities are not advised after replacement.

At Motus, you have more natural options nonoperative knee stem cell treatments in Kansas City.

At Motus, we offer nonoperative knee arthritis stem cell treatments in Kansas City to ideal candidates as an alternative to treat pain and prevent further wearing down of the joint. This can eliminate, or even prolong, the need for knee replacement in many individuals.We do this by using products from your body known as stem cells and platelet rich plasma to promote the joints ability to naturally heal itself. Stem cells are structures that can change (differentiate) into any type of cell in the body. These cells exist throughout the body but cannot get to the area of injury or degeneration with orthopedic conditions because of poor blood flow. At Motus, we harvest stem cells from the patient and concentrate them using a centrifuge (similar to PRP). We then use an ultrasound to guide the stem cells to the exact area in need of treatment. This is often used in combination with PRP. This is a quick in-office procedure that is cost efficient with minimal downtime when compared to traditional surgical approaches.

Am I a candidate for Nonoperative Knee Stem Cell Treatments in Kansas City?

Your initial consultation with Motus will consist of a regular doctors visit. We will ask you about your symptoms and previous treatments, perform a physical examination, and review any x-rays or MRI studies that you have had. We will also perform an ultrasound examination to evaluate the surrounding muscles, tendons, and bursa to see if there are additional conditions other than arthritis (i.e. Bakers cyst) contributing to your pain that may need to be treated in addition to the joint at the time of the procedure. The entire visit is billed to your insurance. Should you be deemed a candidate for nonoperative knee arthritis stem cell treatments in Kansas City, your next visit will be your procedure.

Motus evaluates your knee condition and provides you with a personalized plan of care. Whether this is physical therapy, cortisone or viscosupplementation injections, biologics, or even surgery. Should you not be a candidate for stem cell therapy and require surgery, Motus is pleased to refer you to one of the many terrific local orthopedic surgeons, or to the surgeon of your choice. Motus is here to ensure you are aware of the options available to you.

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Genetics and Molecular Biology Research – iMedPub

Posted: August 2, 2018 at 11:40 am

Genetics & Molecular Biology Journal is an international scholarly, peer reviewed journal presenting original research contributions and scientific advances related to the field of genes, genetic variation and macromolecules. Molecular biology is the study of development, structure and function of macromolecules vital for life. It deals with the molecular basis of biological activity and overlays genetics and biochemistry.

The journal Scope Encompasses structure & functional studies of bio molecular, Cell Biology, Microbial genetics, Biological Molecules, molecular immunology, genetics, genetic disorders, cellular biology and molecular research. It also includes biochemical and molecular influence on genetic material. Genetics & Molecular Biology broadly covers the domains of life, plants, animals, microorganism and human.

The journal accepts manuscripts in the form of original research article, review article, short communication, case report, letter-to-the-Editor and Editorials for publication in an open access platform.

The Journal is using Editor Manager System for easy online tracking and managing of the manuscript processing.

Submit manuscript atwww.editorialmanager.com/imedpub/or send as an e-mail attachment to the Editorial Office at[emailprotected]

Cell biologyis a branch of biology that studies cells their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division, death and cell function. Research in cell biology is closely related to genetics, biochemistry, molecular biology, immunology, and developmental biology.

Related Journals of Cell BiologyCell Science & Therapy, Cell & Developmental Biology, Cellular and Molecular Biology, Cell Biology: Research & Therapy, Molecular Biology, Genes to Cells, Journal of Molecular Cell Biology, Biology of the Cell, Developmental Cell, Developmental Cell, Eukaryotic Cell, European Cells and Materials

Gene technology is defined as the term which include a range of activities concerned with understanding of gene expression, advantages of natural genetic variation, modifying genes and transferring genes to new hosts. Genes are found in all living organisms and are transferred from one generation to the next.Gene technology encompasses several techniques including marker-assisted breeding, RNAi and genetic modification. Only some gene technologies produce genetically modified organisms. We use the most appropriate technique, or combination of techniques, to achieve the desired goal.

Related Journal of Gene Technology

Gene Technology, Journal of Genetic Syndromes & Gene Therapy, Human Genetics & Embryology, Journal of Next Generation Sequencing & Applications, Biochemica et Biophysica Acta - Gene Structure and Expression, Gene Therapy Press, Conservation Genetics, Clinical Epigenetics, Genes, Current Genetics, Gene Expression.

Bioinformatics is the application of computer technology to the management of biological information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied to gene-based drug discovery and development. Bioinformatics tools aid in the comparison of genetic and genomic data and more generally in the understanding of evolutionary aspects of molecular biology. At a more integrative level, it helps analyze and catalogue the biological pathways and networks that are an important part of systems biology. In structural biology, it aids in the simulation and modeling of DNA, RNA, and protein structures as well as molecular interactions.

Related Journalsof Bioinformatics

Proteomics & Bioinformatics, Bioinformatics, Proteins: Structure, Function and Genetics, BMC Bioinformatics, Briefings in Bioinformatics, IEEE/ACM Transactions on Computational Biology and Bioinformatics

Comparative genomics It is an exciting new field of biological research in which the genome sequences of different species - human, mouse and a wide variety of other organisms from yeast to chimpanzees are compared.

Related Journals of Comparative genomics

Journal of Proteomics & Bioinformatics, Journal of Genetic Syndromes & Gene Therapy, International Journal of Biomedical Data Mining, Journal of Pharmacogenomics & Pharmacoproteomics, Functional & Integrative Genomics, Microbiome, Evolutionary and Genomic Microbiology, Genomics and Comparative Genomics, Journal of Virology, Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, BMC Genomics, Comparative and Functional Genomics, Current Bioinformatics

Genetic mutation is a permanent change in the DNA.Mutations may or may not produce changes in the organism.Hereditary mutations and Somatic mutations are the two types of Gene mutations.Former type is inherited from the parents and are present in every cell of the human body whereas latter type may occur at some point of life time due to environmental factors..

Related Journals of Genetic MutationsGenetic Medicine, Genetic Engineering, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, European Journal of Human Genetics, Genetics in Medicine, Human Mutation, Human Molecular Genetics, Genetic mutations Journals, Journal of Genetic Counseling, Genetic Journals, Genetic Disorder Articles, Journal of Genetic Mutation Disorders.

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are usually proteins which functions as enzymes, hormones and receptors. Genes which do not code for proteins such as ribosomal RNA or transfer RNA code for functional RNA products. Gene expression is the process by which the genetic code the nucleotide sequence of a gene is used to direct protein synthesis and produce the structures of the cell. Genes that code for amino acid sequences are called as structural genes.

Related Journals of Gene Expression

Gene Technology, Journal of Next Generation Sequencing & Applications, Journal of Data Mining in Genomics & Proteomics,Journal of Proteomics & Bioinformatics, Transcriptomics: Open Access, Critical Reviews in Eukaryotic Gene Expression, Gene Expression, Gene Expression Patterns, Brain research, Gene expression patterns, Critical Reviews in Eukaryotic Gene Expression.

Molecular cloning is a set of techniques used to insert recombinant DNA from a prokaryotic or eukaryotic source into a replicating vehicle such as plasmids or viral vectors. Cloning refers to making numerous copies of a DNA fragment of interest, such as a gene.

Related Journals of Molecular cloning

Gene Technology, Cloning & Transgenesis, Journal of Next Generation Sequencing & Applications, Journal of Data Mining in Genomics & Proteomics, Transcriptomics: Open Access, Stem Cells and Cloning Advances and Applications, Clinical Genetics, Clinical Genetics, Forensic Science International: Genetics, Advances in Genetics.

Molecular genetics is a branch of genetics and molecular biology that deals with the structure and function of genes at a cellular and molecular level. One of the main achievements of molecular genetics is that now one can have the clarity about the chemical nature of the gene. Molecular genetics is concerned with the arrangement of genes on DNA molecule, the replication of DNA, the transcription of DNA into RNA, and the translation of RNA into proteins. Gene amplification, separation and detection, and expression are some of the general techniques used for molecular genetics.

Related Journals of Molecular Genetics

Journal of Molecular and Genetic Medicine, Tissue Science & Engineering, Cell Biology: Research & Therapy, Advances in Genetic Engineering & Biotechnology, Cloning & Transgenesis, Journal of Molecular Biology: Open Access , Molecular Cell, Genetics and Molecular Biology, BMC Molecular Biology, Advances in Molecular and Cell Biology, Molecular Biology of the Cell

It is the branch that explores the relationship between the immune system and genetics. The term immunogenetics is based on two words immunology and genetics. Immunology deals with the biological and biochemical basis for the body's defense against germs such as bacteria, virus and mycosis.

Related Journals of Immunogenetics

Immunogenetics: Open Access, Journal of Antivirals & Antiretrovirals, Journal of Clinical & Cellular Immunology, Journal of Data Mining in Genomics & Proteomics, Immunogenetics, International Journal of Immunogenetics, Immunology and Immunogenetics Insights, International Journal of Immunogenetics.

Evolutionary Genetics is the study of how genetic variations leads to evolutionary changes. It includes evolution of genome structure, genetic change in response to selection within populations, and the genetic basis of speciation and adaptation

Related Journals of Evolutionary Genetics

Genetic Syndromes & Gene Therapy, Phylogenetics & Evolutionary Biology, Genetic Disorders & Genetic Reports, Cell & Developmental Biology, Journal of Social, Evolutionary, and Cultural Psychology, Journal of Evolutionary Economics, Evolutionary Computation, Genetic Programming and Evolvable Machines, Genetic Counseling, Genetic Epidemiology.

The methods used to identify the locus of a gene and the distances betweengenes.

Related Journal of Gene Technology

Gene Technology, Journal of Genetic Syndromes & Gene Therapy, Human Genetics & Embryology, Journal of Next Generation Sequencing & Applications, Biochemica et Biophysica Acta - Gene Structure and Expression, Gene Therapy Press, Conservation Genetics, Clinical Epigenetics, Genes, Current Genetics, Gene Expression.

Cloning is defined as the processes used to create copies of DNA fragments, cells or organisms. Cloning is commonly used to amplify DNA fragments containing whole genes, but it can also be used to amplify any DNA sequence such as promoters, non-coding sequences and randomly fragmented DNA. It is widely used technique of biological experiments and practical applications including genetic fingerprinting to large scale protein production.

Related Journals of Cloning

Gene Technology, Cloning & Transgenesis, Journal of Next Generation Sequencing & Applications, Journal of Data Mining in Genomics & Proteomics, Transcriptomics: Open Access, Stem Cells and Cloning Advances and Applications, Clinical Genetics, Clinical Genetics, Forensic Science International: Genetics, Advances in Genetics.

Gene Sequencing is the process of determining the precise order of nucleotides within a DNA molecule. It includes any method or technology that is used to determine the order of the four basesadenine, guanine, cytosine, and thyminein a strand of DNA.

Related Journal of Gene Technology

Gene Technology, Journal of Genetic Syndromes & Gene Therapy, Human Genetics & Embryology, Journal of Next Generation Sequencing & Applications, Biochemica et Biophysica Acta - Gene Structure and Expression, Gene Therapy Press, Conservation Genetics, Clinical Epigenetics, Genes, Current Genetics, Gene Expression.

Genetic Engineering is a technique of controlled manipulation of genes to change the genetic makeup of cells and move genes across species boundaries to produce novel organisms.

Related journals of Ethics in genetic engineering

Current Synthetic and Systems Biology, Gene Technology, Genetic Disorders & Genetic Reports Hybrid, Advances in Genetics, BMC Medical Genetics, BMC Genetics, Conservation Genetics, Epigenetics, Infection, Genetics and Evolution, Journal of Assisted Reproduction and Genetics, Neurogenetics, Psychiatric Genetics.

Molecular Medicine strives to promote the understanding of normal body functioning and disease pathogenesis at the molecular level, and to allow researchers and physician-scientists to use that knowledge in the design of specific tools for disease diagnosis, treatment, prognosis, and prevention.

Related Journals for Molecular Medicine

Biomedicine Journals, Journal of Biomedical Science, Journal of Biomedical Research, Translational Biomedicine Journal, Aperito International Journal of Biomedicine, Asian Biomedicine Systems Biomedicine, Biomedical Journal, Biomedicine International Journal, Biomedicine Journal

Molecular biology is the study of biology at the molecular level. The field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry. Cell biology studies the properties of cells including their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division and death. Molecular and cellular biology are interrelated, since most of the properties and functions of a cell can be described at the molecular level. Molecular and cellular biology encompass many biological fields including: biotechnology, developmental biology, physiology, genetics and microbiology.

Related Journals of Molecular Cell Biology

Cell and Developmental Biology, Journal of Cell Biology, Nature Reviews Molecular Cell Biology, Nature Cell Biology, Current Opinion in Cell Biology, Trends in Cell Biology.

The process by which amino acids are linearly arranged into proteins through the involvement of ribosomal RNA, transfer RNA, messenger RNA, and various enzymes.

Related Journals of Protein Interaction

Cell & Developmental Biology, Advancements in Genetic Engineering, Protein Interaction Viewer, Molecular cloning & genetic recombination, Current Synthetic and Systems Biology, Genome Biology, Protein Journal.

Chromosomes andGene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are usually proteins which functions as enzymes, hormones and receptors. Genes which do not code for proteins such as ribosomal RNA or transfer RNA code for functional RNA products. Gene expression is the process by which the genetic code the nucleotide sequence of a gene is used to direct protein synthesis and produce the structures of the cell. Genes that code for amino acid sequences are called as structural genes.

Related Journals of Chromosomes and Gene expression

Gene Technology, Journal of Next Generation Sequencing & Applications, Journal of Data Mining in Genomics & Proteomics,Journal of Proteomics & Bioinformatics, Transcriptomics: Open Access, Critical Reviews in Eukaryotic Gene Expression, Gene Expression, Gene Expression Patterns, Brain research, Gene expression patterns, Critical Reviews in Eukaryotic Gene Expression.

Autoimmune disorders are caused when immune system of the body reacts, against our own body, thus leading to many autoimmune disorders. There are several autoummune disorders they are celiac diseases, diabetes mellitus, graves diseases.

Related Journals of Autoimmune Disorders

Journal of Autoimmune Diseases, Immunome Research, Journal of Clinical & Cellular Immunology, Journal of Autoimmune Diseases and Rheumatology, Open Journal of Rheumatology and autoimmune Diseases

DNA is a molecule that contains the instructions an organism needs to develop, live and reproduce. These instructions are found inside every cell, and are passed down from parents to their children. DNA is made up of molecules called nucleotides. Each nucleotide contains a phosphate group, a sugar group and a nitrogen base.

Related journals of Recombinant DNA

Down Syndrome & Chromosome Abnormalities, Fungal Genomics & Biology, Gene Technology, Genetic Disorders & Genetic Reports Hybrid, Genetic Syndromes & Gene Therapy, Advances in DNA Sequence-Specific Agents, Artificial DNA: PNA and XNA, DNA Reporter.

A genetic disorder is a genetic problem caused by one or more abnormalities in the genome, especially a condition that is present from birth. it occurs as a result of altered gene or by set of genes. Abnormalities can also be small as single base mutation. They can also involve addition or subtraction of entire chromosome. There are four groups of genetic disorders like single gene disorders, chromosome abnormalities, mitochondrial disorders and multifactorial disorders.

Related Journals of Genetic Disorder Human Genetics and Embryology, Cloning and Transgenesis, Carcinogenesis and mutagenesis, Hereditary Genetics: Current Research, Journal of Genetic Mutation Disorders - Annex Publisher, Journal of Genetic Disorders and Genetic Report, Genes and Diseases - Journal - Elsevie, Genetic Disorders - Frontier, Source Journal of Genetic Disorders (SJGD) - Source Journals

One of a group of molecules similar in structure to a single strand of DNA. The function of RNA is to carry the information from DNA in the cell's nucleus into the body of the cell, to use the genetic code to assemble proteins, and to comprise part of the ribosomes that serve as the platform on which protein synthesis takes place.

Related journals of Recombinant DNA

Down Syndrome & Chromosome Abnormalities, Fungal Genomics & Biology, Gene Technology, Genetic Disorders & Genetic Reports Hybrid, Genetic Syndromes & Gene Therapy, Advances in DNA Sequence-Specific Agents, Artificial DNA: PNA and XNA, DNA Reporter.

The passing on of traits from one generation to another generation. Human genetics is the study of inheritance in human beings. Human characteristics are inherited from parents to offspring in discrete unites called genes. Genes consist of specific information coded in the chromosome that consists of segments of chromosomes. Human genetics includes a variety of overlapping fields like classical, molecular, biochemical, population, developmental, clinical and cytogenetics.

Related Journals of Human Genetics

Human Genetics and Embryology, Journal of Cytology & Histology, Hereditary Genetics: Current Research, General Medicine: Open Access, Journal of Molecular and Genetic Medicine, Immunogenetics: Open Access, American, Journal of Human Genetics, Annals of Human Genetics, Annual Review of Genomics and Human Genetics, Current Protocols in Human Genetics, European Journal of Human Genetics, Human Genetics, Twin Research and Human Genetics, International Journal of Human Genetics, Journal of Human Genetics

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Genetics and Molecular Biology Research - iMedPub

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Epigenetics: DNA Methylation, Chromatin Modification …

Posted: August 1, 2018 at 4:49 pm

Epigenetics describes changes that are stable, but potentially reversible alterations in gene expression, that occur without permanent changes in DNA sequence and can still be passed on from generation to generation. Epigenetically controlled genes are activated or repressed without any change in DNA. Three central epigenetic mechanisms that play an essential role in gene regulation have been extensively studied by researches, including DNA methylation, histone modification, and RNA regulation. Our combined comprehensive Epigenetics portfolio offer high quality products to perform the techniques being utilized to study all the three central epigenetic mechanisms.

Quantitative detection of histone modifications is important to a better understanding of epigenetic regulation of cellular processes in normal or cancer tissues. The most widely used techniques to study how histone modifications and other DNA binding proteins, such as transcription factors, influence gene expression is called chromatin immunoprecipitation (ChIP) combined with qualitative polymerase chain reaction (qPCR). ChIP involves chemically crosslinking proteins to DNA sequences, which is followed by immunoprecipitation of the crosslinked complexes by using antibodies and beads to pull down the modified histone or other proteins of interest. Below are some selected products for your research in histone modification. The most commonly studied and best understood histone modifications are acetylation, phosphorylation, methylation, and ubiquitination. Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. We offer a wide range of kits for analyzing complex histone modifications patterns.

Histone Modification Assays

Methylated DNA Enrichment, Isolation, Visualization and Quantification

Whole genome amplification (WGA)

Transcriptome Amplification

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Epigenetics | Abcam

Posted: August 1, 2018 at 4:49 pm

Epigenetics | Abcam

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Home Epigenetics and Nuclear Signaling

See how we can help you with your epigenetics research. Take a look at our latest webinars, protocols, and guidescovering a range of epigenetic areas including DNA methylation, RNA modifications, histone modifications and non-coding RNAs.

Articles and webinars on the newest DNA methylation techniques, and products for your experiments.

Explore the unexplored. See our rangeof antibodies and resources for RNA modifications, their readers, writers, and erasers.

Popular protocols for applications such as chromatin immunoprecipitation (ChIP), RIP, and CLIP.

Keep up-to-date with recent advances in epigenetics, including product and research information.

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Stem cells relieve chronic pain in Kansas City, MO

Posted: July 30, 2018 at 10:41 pm

Stem cell treatment is used to treat many different issues

Stem cells are used to treat a variety of issues for patients in Kansas City and Lees Summit, MO and across the country. These little parts of the body, work to provide long term pain relief for people who struggle with pain stemming from old injuries, or who have diseases like osteoporosis and disc degeneration.

At Rejuvenate Mind-Body Wellness Center, we use umbilical stem cells to perform our stem cell therapy procedures. But, many people dont know why we use those types of cells and how the treatment works. Learn more below.

Stem cells are smart and work to repair the damaged area

Stem cell treatments provide patients with long term pain relief. When you have this treatment, well inject the stem cells into the area that is causing you pain. Once injected, these cells know where to go and will race to the damaged area and set to work. Theyll start to multiply and repair the damage, which gives you long term relief from your pain.

Most patients only require one injection to see results, but, they wont see results right away. The new stem cells need time to start to work. So, it can take a few months before patients see full results, though some may start to feel better within a month or two.

Umbilical stem cells are used to save patients time and money

At Rejuvenate Mind-Body Wellness Center we use umbilical stem cells that are harvested from live births. Many patients want to know why we use these stem cells, instead of stem cells from their body. There are a few reasons for this.

First, harvesting stem cells from your body can be expensive. Second, it can be painful to have stem cells harvested. By using donated cells that were not painful to harvest, we save you going through pain and an additional procedure. Third, these cells are undifferentiated and immunonaive, meaning your body wont see them as foreign so it wont attack the new cells.

These stem cells are carefully screened to ensure they are free of diseases, just like blood donations are screened. They are also donated from full term, live, healthy births.

Stem cell therapy in Kansas City and Lees Summit MO

Kansas City and Lees Summit, MO residents who battle chronic pain from injuries, illnesses, or diseases can find relief through stem cell therapy. This treatment uses stem cells to repair damage in the affected area which gives you long term relief from your pain. Contact our office to learn more about this treatment option and to see if its an option for you.

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Integrative & Lifestyle Medicine | Cleveland Clinic

Posted: July 30, 2018 at 10:41 pm

Cleveland Clinic's Center for Integrative & Lifestyle Medicine is dedicated to addressing the increasing demand for integrative healthcare by researching and providing access to practices that address the physical as well as lifestyle, emotional, and spiritual needs of patients.Our team of Cleveland Clinic Integrative and Lifestyle Wellness experts will share their tips for taking control of your health. By guiding you through dietary and lifestyle changes, our integrative specialists will explain how alternative therapies can complement your lifestyle for optimal wellness.

As the body of evidence for alternative medicine grows, we remain at the forefront providing the most updated education and practices to patients. Cleveland Clinic's Center for Integrative & Lifestyle Medicine sees more than 5,000 patients per year for a variety of services.

Meet our practitioners and learn more about integrative & lifestyle medicine at any of our health events.

Disclaimer: Cleveland Clinic does not endorse Young Living Essential Oils Products and has not authorized the use of its name in association with Young Living Essential Oils Products.

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Stem cell therapy and healing meniscus damage – Dr. Marc …

Posted: July 29, 2018 at 10:44 pm

Marc Darrow MD, JD. Thank you for reading my article. You can ask me your questions about stem cells and meniscus injury using the contact form below.

Often I will hear remarkable statements in emails. Here is an example of one shared about knee pain.

This person contacted me because they were interested in a stem cell program to help them avoid a knee replacement. He reported that he had an arthroscopic surgery to remove part of his meniscus recently. The doctor who performed the surgery told his patient to make sure he called him when they were ready for knee replacement.The doctor said that he was already familiar with this patients knee anatomy and he could be counted on to do a good job when it was time for the replacement.

As the predicted knee degeneration occurred, the patient instead reached out to us and stem cell therapy. Hindsight and foresight, the person had wished they would have reached out before the surgery so we could have helped with his meniscus repair.

New research into the healing world of the knee meniscus is fascinating. Despite decades of traditional medical beliefs that because of its poor or even absent network of blood vessels and blood supply, parts of the knee meniscus cannot heal. Researchers are discovering the meniscus is in fact, always trying to heal itself.

Can a meniscus really regenerate itself? This is a question I am often asked. The answer is yes, in some circumstance.

In 2011, three doctors from the North Middlesex University Hospital in the United Kingdom published a strange case history in the medical journal Case Reports in Medicine. What was odd about this case was that a 70 year old man who had recently undergone total knee replacement was suffering from terrible knee pain. It wasnt the knee pain that was odd, patients frequently report knee pain after knee replacement. What was strange to the doctors was what was causing the knee pain. Here is their case:

Report: The patients surgery had taken place at another hospital, and he had made an initially uneventful recovery with a good clinical range of motion and satisfactory postoperative radiographs. At 9 months, however, he began to develop medial and lateral retinacular (middle and side tendon related pain) and deep knee pain, without associated knee swelling, warmth, or wound disturbance. (No infection or apparent injury) His symptoms steadily worsened, particularly with load-bearing activity and bending his knee past 80 degrees.

Meniscus tissue was growing inside the knee replacement

Our patient was found to have soft-tissue entrapment between the femoral component and the polyethylene tray . . . suggestive of meniscus-like tissue. Meniscal regeneration has been previously described in experimental and clinical studies following meniscectomy and has also been previously reported following TKA (total knee replacement).(1)

Studies suggest that this is possible because the meniscus is always trying to heal itself. How did this patient story end? Another surgery, arthroscopic debridement to remove the new meniscus tissue because it was trapped in the hardware.

What was the moral of the story? Make sure you do not leave any meniscus behind in total knee replacement, it may regrow itself, and a70 year old man was not too old to grow new meniscus tissue and his own stem cells had something to do with it.

A new study in the Journal of orthopaedic research lead by the Department of Orthopaedics and Rehabilitation, University of Iowa discusses how a meniscus regenerates and heals.

The researchers hypothesized that the meniscus contains a population of regenerative cells, (cells that stimulate stem cell activity) and that they migrate to the site of meniscal injury. In the above study that is what the doctors speculated happened to their patient.

However, studies revealed that migrating cells were mainly confined to the red zone in normal menisci: (This is the area where the meniscus has good blood flow and healing elements are abundant). However, these cells were capable of repopulating defects made in the white zone, (the area without circulation). When the meniscus was injured, migrating cell numbers increased dramatically. Stem cells in the knee increased in number to combat the injury.These findings demonstrate that, much as in articular cartilage, injuries to the meniscus mobilize an intrinsic progenitor cell population with strong reparative potential, even into the white zone area.(2)

The short of it? The meniscus figures out how to heal itself if it can. Even in the areas that are typically believed unhealable because of lack of blood flow to that area.

Stem cell numbers?What is even more fascinating is that the meniscus signals for more stem cells from the knee capsule to come to the injured area. For those people asking about stem cell numbers that are harvested for treatment, you wont get an answer from the meniscus because it is mobilizing the stem cells already in the knee. Sometimes the meniscus only needs little spark, an injection of own stem cells to facilitate an abundant healing.

If you had a meniscus tear you are familiar with White Zone, and Red Zone, meniscus tears.The Red Zone, part of the meniscus, the outer edges, receives a steady stream of healing cells from its well organized blood vessel network. For those of you with a meniscus injury that is being recommended to surgery, you may have had your doctor explain to you that you have a White Zone, tear. The White Zone, lies in the center of the meniscus. It does not have a well organized blood network. It is these meniscal injuries that send patients to surgery. Unfortunately because of the lack of blood supply the damaged tissue needs to be removed.

In the Journal of orthopaedic research doctors examined the process of meniscal regeneration and cartilage degeneration following meniscus surgical removal in mice. They found that there is ahealing environment that the meniscus and cartilage create independently of each other spurred on by native stem cells, that later melds together, suggestive of a balance between meniscal regeneration and cartilage homeostasis.(3)The meniscus and cartilage are trying to regenerate each other.

This special relationship between cartilage, meniscus and stem cells is discussed in new research from the University of Iowa. The Iowa findings demonstrate that, much as in articular cartilage, injuries to the meniscus mobilize an intrinsic progenitor (stem cell) population with strong reparative potential.(4)The problem for patients is that despite the desire to heal and regenerate, as pointed out by the Iowa researchers, Serious meniscus injuries seldom heal and increase the risk for knee osteoarthritis; thus, there is a need to develop new reparative therapies. In that regard, stimulating tissue regeneration by autologous stem/progenitor cells has emerged as a promising new strategy.(4)

In past articles I have written extensively about how stem cells change the environment of diseased joints to healing. Research like that above confirms that when one part of the knee is repairing, the entire knee is repairing. This change of environment is something a surgery cannot offer.

Doctors at the University of Southern Denmarkconfirm this:

Patients undergoing arthroscopic partial meniscectomy are at increased risk of knee osteoarthritis. Meniscal damage and/or Meniscal surgery may alter knee-joint loading (the distribution of weight across the knee) to increase osteoarthritis risk.(5)

As noted, research has suggested poor long-term outcomes for patients with meniscectomies with increased incidence of osteoarthritis, leaving a need to develop technology to regenerate meniscal tissue following meniscectomy. The answer is stem cells.(6)

As you have seen in this article, the meniscus has a remarkable ability to heal itself. When someone comes into our office with knee problems we start with a conversation so we can learn about the patients lifestyle and what are his/her goals of the treatment. Is it to get back to marathon training or is it to get up and down a staircase without his/her knee locking up? Then we will do a detailed physical examination looking for those signs that will tell us how helpful stem cell therapy may be.

STEM CELL INSTITUTEA leading provider of bone marrow derived stem cell therapy, Platelet Rich Plasma and Prolotherapy in Los Angeles and the world!11645 WILSHIRE BOULEVARD SUITE 120, LOS ANGELES, CA 90025PHONE: (800) 300-9300

1 Matar HE, Dala-Ali B, Atkinson HD. Meniscal regeneration: a cause of persisting pain following total knee arthroplasty. Case reports in medicine. 2011;2011.

2 Seol D, Zhou C, Brouillette MJ, Song I, Yu Y, Choe HH, Lehman AD, Jang KW, Fredericks DC, Laughlin BJ, Martin JA. Characteristics of meniscus progenitor cells migrated from injured meniscus. Journal of Orthopaedic Research. 2016 Nov 1.

3 Hiyama K, Muneta T, Koga H, Sekiya I, Tsuji K.Meniscal regeneration after resection of the anterior half of the medial meniscus in mice.J Orthop Res. 2016 Nov 2. doi: 10.1002/jor.23470. [Epub ahead of print]

4 Seol D et al. Characteristics of meniscus progenitor cells migrated from injured meniscus. J Orthop Res. 2016 Nov 3. doi: 10.1002/jor.23472.

5Thorlund JB, Holsgaard-Larsen A, Creaby MW, et al.Changes in knee joint load indices from before to 12 months after arthroscopic partial meniscectomy: a prospective cohort study. Osteoarthritis Cartilage. 2016 Jul;24(7):1153-9. doi: 10.1016/j.joca.2016.01.987. Epub 2016 Feb 2.

6. McCrum CL, Vangsness CT. Postmeniscectomy Meniscus Growth With Stem Cells: Where Are We Now? Sports Med Arthrosc. 2015 Sep;23(3):139-42. doi: 10.1097/JSA.0000000000000073.

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Stem Cell Research Facts | Charlotte Lozier Institute Project

Posted: July 29, 2018 at 10:44 pm

Learn the answers to questions like ..."Who is benefitting from stem cell research and therapies today?" and "What types of stem cells are working?" In addition, basic questions such as "What is a stem cell?""Why do we need stem cell research?" are answered.

The video patient profiles featured on this site emphasize ADULT stem cell advances with the goal of informing and the hope of inspiring you to take action. These stories represent a small sampling of people and the many diseases and conditions now being treated by adult stem cells naturally found in the human body. Stem Cell Research Facts illustrates how current adult treatments and therapies directly impact the lives of patients and their families today - as opposed to debating the merits of other types of stem cell research.

We invite you to discover, learn and share the incredible possibilities of stem cell research. We welcome your feedback and encourage you to return for the latest developments in the world of stem cell research. Thank you!

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Stem Cell Research Facts | Charlotte Lozier Institute Project

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