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Facts About Cellular Therapies

Posted: July 29, 2018 at 10:42 pm

Cellular therapy (CT) is the transplantation of human cells to replace or repair damaged tissue and/or cells. With new technologies, innovative products, and limitless imagination, many different types of cells may be used as part of a therapy or treatment for a variety of diseases and conditions. Some of the cells that may be used include hematopoietic (blood-forming) stem cells (HSC), skeletal muscle stem cells, mesenchymal stem cells, lymphocytes, dendritic cells, and pancreatic islet cells.

While the research is evolving, various cell types will be developed into treatments as novel cell therapies and studied for potential applications. Hematopoietic stem cell transplantation (also called bone marrow transplant) is the most frequently used cell therapy and is used to treat a variety of blood cancers and hematologic conditions. Potential applications of cell therapies include treating cancers, autoimmune disease, urinary problems, and infectious disease, rebuilding damaged cartilage in joints, repairing spinal cord injuries, improving a weakened immune system, and helping patients with neurological disorders.

Regenerative Medicine

Hematopoietic Stem Cells

Hematopoietic Stem Cells for Donation

How are Stem Cells Regulated?

The Role of Standards and Accreditation

Considerations for Health Care Consumers

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Stem Cell Therapy | Spine & Joint Solutions – Colorado Springs

Posted: July 29, 2018 at 10:40 pm

Stem cell therapy is an exciting part of a rapidly growing area within medicine termed Regenerative Medicine. Stem cells are cells that have the opportunity to become several different tissue types and also have the ability to self-replicate. Stem cells are found throughout the body in certain tissues and in varying concentrations. Bone marrow and adipose tissue both have high concentrations of stem cells and are readily available within the body.

Bone Marrow Aspiration (BMA)

At Spine & Joint Solutions, a procedure called bone marrow aspiration is performed to collect stem cells for use in areas of injury. The procedure is performed at a surgical center so that sterile technique can be used, as well as x-ray guidance to ensure that the whole procedure is as safe as possible. The aspiration process typically takes between 5 and 10 minutes and begins with having a patient lie on a bed on his/her stomach. The iliac crest bone, or top ridge of the hip bone, is the location chosen from which to draw bone marrow out. The region is sterilized and then anesthetized to reduce any discomfort. A needle is then advanced into the iliac crest, and only of the amount of bone marrow product that is needed for treatment is aspirated from the region. The needle is then removed. Given that the bone marrow aspiration technique that is used by Dr. Martin is the most advanced on the market at this time and effectively concentrates the product during the aspiration process, no centrifuge duration of the bone marrow is necessary. This, in turn, shortens the overall procedure and causes less potential harm to the bone marrow product. The bone marrow aspiration (BMA) product is then ready to be injected into the desired area. If the target is the joints or soft tissue, then an ultrasound is used to help guide the needle directly into the region of damage. If the target is the spine, a fluoroscope (x-ray machine) is used to help guide the needle into the region of damage. When stem cells are placed in an area of degeneration or injury within the body, these cells have the ability to decrease local inflammation and heal damaged tissue.

Donor Stem Cells

There are certain situations in which using bone marrow-derived stem cells is not the best option. In these situations, further discussions about donor stem cells are reasonable and necessary. Any individual who is known to have a chronic illness, such as a rheumatologic condition, or a person who has been treated with chemotherapy or radiation, may not have extremely healthy stem cells, as your stem cells are only as healthy as you are. In addition, more recent literature has outlined that any individual over the age of 60 should consider using donor stem cells due to having a low concentration of stem cells within their own body.

Following a health, full-term delivery, the placenta and umbilical cord may be collected. Stem cells are then collected from the Whartons jelly within the umbilical cord. The final stem cell product is then placed in a vial and stored at -196. At the time of your treatment, the product is thawed within the vial, drawn into a syringe and placed into the target area under either ultrasound or fluoroscope guidance.

Stem cell therapy is a safe and conservative treatment option for multiple musculoskeletal conditions, including joint degeneration, cartilage injury, tendon injury, ligament injury, facet joint injury and disc injury.

All regenerative medicine patients at Spine & Joint Solutions will receive a comprehensive approach to their treatment process. This will include a full consultation, during which all questions will be answered. A packet will be provided that includes information on what to expect before, during and after the procedure. This will include post-injection protocols and activity modifications, as well as what to expect from the rehabilitation process, which begins four weeks after the injection. An outline describing an anti-inflammatory diet, suggested supplements, and recipes will also be included. Patients may be asked to wear a brace or use crutches to offload the joint or spine region that was treated.

Additionally, each patient who undergoes treatment with either PRF or stem cells will be asked to take part in the research that is being conducted at Spine & Joint Solutions. This will consist of filling out simple questionnaires before treatment and again at specific points following treatment. Repeat imaging may be pursued to ensure tissue healing.

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Stem Cell Therapy | Spine & Joint Solutions - Colorado Springs

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FAQ – Stem Cell Center Of NJ – New Jersey Stem Cell Therapy

Posted: July 29, 2018 at 8:47 am

Is all stem cell therapy the same?

No! There are many options in stem cell therapy. Variables include the use of stem cells, the source of stem cells, growth factors, cell byproducts and therapies to enhance blood flow. Selection of one or a combination of any sources of cells, as well as, the processing of the products, and combination of products used, allow for the selection of individualized treatment based on the medical condition, severity of the condition, age of the patient, and the existence of any additional or contributing medical conditions.

Traditionally, medicine has only treated the symptoms that disease, illness and injury cause, rather than treating the root cause of these conditions. Regenerative medicine is a game-changing frontier, and takes a different approach altogether it holds the promise of being able to actually heal a patients body from within. Regenerative medicine is the ability to use the latest in medical technology to help restore structure and function to damaged tissues and organs within the body.

At Stem Cell Center of NJ our quality control program ensures that our Platlet Rich Plasma (PRP) preparations are consistent and high quality, and our PRP preparations can be individualized to meet your specific therapy needs.

Platlet Rich Plasma (PRP) has been in the news and written about in scientific and medical journals regarding its potential effectiveness toward treating injuries. Several famous athletes such as Tiger Woods, tennis star Rafael Nadal and several others have received PRP for knee and chronic tendon injuries, and many of them credit PRP therapies toward returning them more quickly to their sport. Here are a few of the questions surrounding PRP, and how it works as a treatment:

At Stem Cell Center of NJ were well-versed on sports injury therapies, and offer treatment for back, shoulder, knee, hip pain as well as spinal injuries. Our goal is to get you back to feeling like yourself, so that you can resume your normal activity level quickly. We understand that a sports injury can be anywhere on the spectrum of annoying to a catastrophic event they can effect even the most seasoned athlete or the novice weekend warrior. Serious athletes must understand that managing their

injury effectively is part of the game they must play to achieve continued success, also that rehabilitation skills are similar to sports skills.

There are four factors which influence recovery:

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FAQ - Stem Cell Center Of NJ - New Jersey Stem Cell Therapy

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Helping You Decide | Rhode Island Cord Blood Banking

Posted: July 27, 2018 at 10:44 pm

The wheres, whats and hows When you are having a baby, there are dozens of decisions to make. One of the most important things you will have to decide is whether to bank your babys cord blood. In order to make the decision, which is best for you and your family, it is essential to Continue Reading

The research If you are expecting a baby then no doubt youve heard the phrase cord blood banking quite often. Parents today are bombarded with choices practically from the moment of conception, most of which pertain to the babys birth and immediate care following. Cord blood banking is no exception and you may have several Continue Reading

Typical costs associated with cord blood banking and storage Most expectant couples want to do everything possible to protect the health of their newborn child. New developments in medicine have made it possible to use the stem cells found in a babys umbilical cord to develop new treatments to fight diseases like leukemia. The babys Continue Reading

Your babys own stem cells from the normally discarded umbilical cord Most pregnant women and expectant parents have heard about cord blood banking and its ability to store cord blood stem cells for later use. For those of you who havent, cord blood banking uses the latest in technology to extract and preserve all the Continue Reading

The options for cord blood banking in Rhode Island are as good if not better than many states

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Stem Cell North Charleston South Carolina 29405

Posted: July 27, 2018 at 6:45 am

Stem cell treatment has become a popular dispute in the worldwide medical scene. This extremely controversial treatment has received mixed opinions from various stakeholders in the health care market and has likewise drawn in the attention of politicians, religious leaders and the general population at large. Stem cell therapy is considered a revolutionary treatment for people suffering from a wide variety of degenerative conditions. Some common questions regarding this treatment are responded to below.

Stem cells can be described as blank state or non-specialized cells that have the capability to become customized cells in the body such as bone, muscle, nerve or organ cells. This means that these unique cells can be used to restore or establish a wide range of damaged cells and tissues in the body. Stem cell therapy is therefore a treatment that targets at accomplishing tissue regrowth and can be used to cure health conditions and diseases such as osteoarthritis, degenerative disc disease, spinal cord injury, muscular degeneration, motor nerve cell illness, ALS, Parkinsons, cardiovascular disease and much more.

Stem cells can be drawn out from a young embryo after conception. These stem cells are commonly described as embryonic stem cells. After the stem cells are drawn out from the embryo, the embryo is terminated. This is basically one of the significant causes of controversy in the field of stem cell research study. Many people say that termination of an embryo is dishonest and undesirable.

Stem cells can still be obtained through other methods as they can be found in the blood, bone marrow and umbilical cords of adult humans. Normal body cells can also be reverse-engineered to become stem cells that have limited abilities.

Being a treatment that is still under research, stem cell treatment has actually not been completely accepted as a practical treatment option for the above discussed health conditions and diseases. A lot of studio is presently being performed by researchers and medical specialists in various parts of the world to make this treatment viable and effective. There are however various restrictions enforced by governments on studio involving embryonic stem cells.

Currently, there have not been many case studies performed for this type of treatment. Nevertheless, with the few case studies that have been carried out, one of the major concerns that has been raised is the increase in a patients danger of establishing cancer. Cancer is brought on by the fast reproduction of cells that tend not to die so easily. Stem cells have been associated with similar development elements that might cause development of tumors and other cancerous cells in clients.

New studio has nevertheless revealed pledge as researchers target at establishing stem cells that do not form into tumors in later treatment stages. These stem cells can for that reason efficiently change into other types of specialized cells. This treatment is therefore worth investigating into as numerous clients can benefit from this advanced treatment.

The best stem cell therapy in North Charleston SC 29405

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Stem Cell North Charleston South Carolina 29405

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75% of Cancer Stem Cells Died When Attacked By Compound in …

Posted: July 27, 2018 at 6:44 am

by Mary West

Potent cancer-fighters are hidden within the leaves, stalks, husks and stems of cruciferous vegetables like watercress and broccoli.

A study shows a compound and enzyme found in these foods can kill cancer stem cells, which is a discovery that could help prevent the re-occurrence and spread of some malignancies.

According to lead author Moul Dey, cancer stem cells present quite a danger. They are resistant to chemotherapy and radiation, so they continue to live in the body after such traditional treatments. While the stem cells only comprise about 5 percent of a cancerous tumor, they act like a ticking time bomb. These tiny cells are very difficult to detect in a tumor, she says. Its like finding a needle in a haystack. Consequently, they can migrate through the blood vessels, thus causing the cancer to metastasize.

When cruciferous vegetables are eaten, a compound and enzyme combine during the chewing process to form phenethyl isothiocyanate (PEITC). Scientists at South Dakota State University tested the effects of this substance, known as PEITC, on human cancer stem cells in a Petri dish. The results were impressive, as 75 percent of the cells died within 24 hours. Even low concentrations of it proved effective. This finding builds upon previous research that reveals the anti-cancer properties of similar foods.

When a tumor outgrows its blood supply, it sends a sign to surrounding tissues to deliver more nutrients and oxygen. Prior studies show PEITC switches off this sign.

Cruciferous vegetables include watercress, broccoli, cabbage, cauliflower, Brussels sprouts, radishes, arugula, bok choy, kale, turnips and rutabaga. The researchers found concentrations of PEITC were particularly present in land and watercress. If you want to ingest the amount of PEITC used in the research, eat a diet rich in these vegetables, especially watercress.

A study published in the American Journal of Clinical Nutrition found a daily serving of watercress can significantly curtail DNA damage to blood cells, a problem thought to be a major trigger of cancer. In addition, the vegetable boosted the ability of the cells to resist further harm perpetrated by free radicals. This study is one within a body of accumulating research that indicates watercress may reduce the risk of colon, breast and prostate cancer.

Live in the Now consulted Sylvia Melndez-Klinger, registered dietitian and leading expert in cross-cultural Hispanic cuisine as it relates to health. She shared the recipe below that combines two extraordinarily healthful foods: watercress and fatty fish. Everyone should aim to eat 2 to 3 servings of fish, especially those high in omega-3 fatty acids, each week to reap the benefits that include cognitive function, heart health and more, she says.

Tarragon Tuna Watercress Salad

1/2 cup reduced fat mayonnaise 1/4 cup low fat sour cream 1/4 cup fresh tarragon, chopped or 2 teaspoons dried 1 teaspoon grated lemon zest plus 1 tablespoon fresh lemon juice 2 5-ounce cans solid white albacore tuna fish in water, drained 2 green onions, sliced 2 celery stalks, sliced ground pepper to taste 1 pound watercress, thick stems removed

In a medium bowl, mix together the mayonnaise, sour cream, tarragon, lemon zest and juice. Gently fold in tuna fish, green onions, and celery. Season with pepper and serve over the watercress.Makes: 4 servings

Sources:https://www.yahoo.com/health/broccoli-watercress-may-hold-potent-118305401687.htmlhttp://news.therawfoodworld.com/how-to-kill-cancer-stem-cells/http://www.medicalnewstoday.com/articles/63314.phphttp://naturalsociety.com/watercress-block-breast-cancer-cell-growth/

Mary West is a natural health enthusiast, as she believes this area can profoundly enhance wellness. She is the creator of a natural healing website where she focuses on solutions to health problems that work without side effects. You can visit her site and learn more at http://www.alternativemedicinetruth.com. Ms. West is also the author of Fight Cancer Through Powerful Natural Strategies.

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Oregon Stem Cell Center Result of OHSU Research Strides …

Posted: July 26, 2018 at 3:49 pm

Portland, Ore.

New hub to focus on adult stem cells as organ transplant alternative

Oregon Health & Science University's fast-growing stem cell research program, which already has made significant strides in the hunt for human disease therapies, now has a place to call home.

The multidisciplinary Oregon Stem Cell Center, the first of its kind in the Northwest, is studying cell and gene therapy as an alternative to organ transplantation for pancreatic and liver disorders, diabetes, cancer and a host of other human diseases. Its focus will be on adult stem cells.

Launched in January, the center is housed among several laboratories on the Marquam Hill Campus, but it will occupy a single floor in the 270,000-square-foot Biomedical Research Building now under construction and to be completed in fall 2005.

Its director, Markus Grompe, M.D., professor of molecular and medical genetics, and pediatrics in the OHSU School of Medicine, said the center is a hub for all areas of OHSU's rapidly expanding stem cell biology program. It aims to maximize the potential of various stem cells as therapies for human diseases through a rapid, "bench-to-bedside" approach involving basic research in stem cell biology and preclinical trials of therapies in animal models, followed by human trials.

"This is something we needed but didn't have," said Grompe, who has long studied gene and cell therapy for metabolic genetic diseases, as well as the molecular genetics of a rare, cancer-susceptibility syndrome called Fanconi anemia. "The consensus here at OHSU is that this is an area that is going to be important."

While the center's offerings will widen over time to cover other diseases -- Parkinson's disease and diabetes are considered "hot" areas of stem cell research -- it will concentrate on two areas for now and "build on that."

"My idea is to focus on the liver and the pancreas, and focus on adult stem cells," he said. "Our research already is advanced in liver reconstitution by stem cells and the repair of liver disease. We're clearly identified as one of the leaders in that area."

OHSU researchers like Grompe are wasting no time demonstrating the importance of stem cells. His laboratory is renowned as an international leader in cell therapy for liver and pancreas diseases as an alternative to organ transplantation.

Last year, Grompe published a study showing that bone marrow-derived stem cells from mice can combine with liver cells through cell fusion, which occurs when two or more cells combine to form one cell containing more genetic material than normal. The method reversed liver damage.

Other studies indicate bone marrow stem cells can meld with cells of other tissues, such as brain, spinal cord, lung, intestine and heart muscle.

The center's formation reflects a swell of research at OHSU involving stem cells. Scientists are conducting basic research, including molecular-level studies, in cardiology, endocrinology, genetics, hematology and oncology, neurology, neurological and general surgery, and reproduction.

"Basically all diseases which are currently being treated by organ transplantation are, at least on paper, amenable to cell therapy," Grompe said. "Our hope is that procedures as effective as whole organ transplantation will come out of (the center)."

Of particular interest to School of Medicine scientists are recently discovered clonally self-renewing stem cells. These unique cells have energized stem cell research - and are broadening the discipline's appeal to a larger group of scientists - because of their ability to generate copies of themselves and further divide into special-purpose offspring.

Clonally self-renewing stem cells come in several forms, such as mesenchymal stem cells, neural stem cells and multipotent progenitor cells, and can be used to create multiple cell types, including nerve cells, liver cells and muscle cells. They can be isolated from mice and primates, including humans, manipulated outside the living organism, and transplanted for reconstituting tissue.

"Their ability to be expanded in culture and then differentiated make them attractive for use in cell therapy," Grompe said.

Dan Dorsa, Ph.D., OHSU vice president for research and professor of physiology and pharmacology in the School of Medicine, said stem cells hold promise for treating many disorders. As a result, OHSU has the potential to make "a very broad impact."

"The use of stem cells for treating diseases will be at the forefront," Dorsa said. "The question we want to answer is: What is it about stem cells that allow them to be viable and take on the roles in the body you hope they will?"

The Oregon facility is one of only a handful of stem cell research centers around the country. Other sites include the University of Minnesota, Stanford University, the University of California, San Francisco, and the University of California, San Diego.

The heart of the center is three core facilities that provide cell development and management services for all campus research. They include:

A flow-sorting core to identify and isolate stem cell populations and characterize their progeny using fluorescence. Its primary tool, a fluorescence-activated cell sorter, "fishes out living stem cells and keeps them alive for transplantation and study," Grompe said.

A cell isolation core to culture, store and distribute specific stem cells. This will allow many researchers at OHSU rapid and easy access to professionally isolated and maintained, high-quality stem cell sources.

A monoclonal antibody production core to develop the large quantities of novel antibodies needed for identifying and purifying specific stem cells. Such a service has not been commercially available. "We'll be able to give cells to the core and get antibodies back for researchers," Grompe said. "And the antibodies don't have to be against stem cells to be effective."

The monoclonal antibody production core will be especially useful to cancer researchers, said Grover Bagby Jr., M.D., professor of molecular and medical genetics, OHSU School of Medicine, and director of the OHSU Cancer Institute.

"Having the capacity to make antibodies is going to be a nice core to have," he said. "I think a good number of cancer researchers will come to use that core. It'll be used right out of the gate."

And that could help scientists better track the progression of cancer, most forms of which are mutant outgrowths of stem cells.

"Understanding the cause of cancer definitely leads squarely into the ballpark of stem cells. We know it's true of leukemia and I suspect it's probably true of all other tissues," Bagby said. "There are a lot of things we can learn about stem cells that can lead to an understanding of how to protect them."

Dorsa and Grompe hope the center bolsters the development of OHSU-born spinoff companies while enhancing the university's partnerships with local and national biotechnology firms. It also could make OHSU more of a target for federal grants.

"There are very likely new industries that will be created by virtue of the new activity of the center," Dorsa said. The antibody core, for example, "will be attractive to commercialization."

The Oregon Stem Cell Center is funded by a three-year, $4.5 million grant from the Oregon Opportunity, the statewide, $500 million biomedical research funding initiative supported by public and private dollars. Three faculty members specializing in stem cell research also will be hired during the next two years.

Dorsa believes the Oregon Stem Cell Center fits in well with the National Institutes of Health's "Roadmap" initiative, which strives to accelerate fundamental discovery and translation of that knowledge into effective prevention strategies and new treatments.

"NIH dollars will be attracted by the stem cell center and the investments it will create," Dorsa said. "We think this one will be well positioned to compete for those dollars."

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Research: Surgeons too enthusiastic about offering spinal …

Posted: July 26, 2018 at 3:49 pm

In our practice we often see patients who are in severe back pain. They have an MRI, X-ray and/or scan that shows an inaccurate picture of what is causing their pain. The MRI cannot show muscle spasms from a simple back strain which can cause excruciating pain. Conversely, the MRI can show a large herniated disc which may be completely painless. Yet that large herniated disc will send the patient to surgery. As you will read in the research below, this was considered unsupported enthusiasm for the surgical management of discogenic back pain. Now surgeons are publishing new data with a tempered enthusiasm.

Marc Darrow MD, JD. Thank you for reading my article. You can ask me your questions about degenerative disc disease using the contact form below.

The decision to perform surgery in patients with predominantly axial pain (low back pain caused degenerative disc disease) should be made with the understanding that many patients may not respond to the treatment.

April 2018,European journal of orthopaedic surgery & traumatology

In a study out of Greece, surgeons reassessed a few of the most commonly performed spinal fusion alternative surgical procedures.(1) Their reassessment surroundedadjacent level disease. This is advanced degeneration above and below the fusion site. The researchers of this study examinedmotion preservation surgical methods that were recently developed in order to overcome this complication.

(Motion preservation surgical methods) include total disc replacement, laminoplasty (cutting away of bone and other pressure causing material on the nerves), interspinous implants (spacers to hold nerve pathways open) and dynamic posterior stabilization systems (not a fusion but similar. This procedure allows controlled movement of the spine).

What is being said in the above research and the below research is, these surgeries may not be as helpful as doctors thought.

In an editorial from theDepartment of Neurosurgery, University of Virginia, doctors found: Without prospective trials with non-conflicted surgeons and standardized selection criteria, the true role for sacroiliac jointfusion procedures in the treatmentof chronic lower back pain will remain murky. The consequences of the unsupported enthusiasm for the surgical management of discogenic back pain still negatively impacts the public perception of spinal surgeons. 2

Enthusiasm they say from surgeons is not realistic. When the surgical outcome is poor, the patients are surprised. Researchers say patients should have been told upfront of the likelihood of complication

Journal of back and musculoskeletal rehabilitation, May 2017

Four to fifty percent of patients will developFailedBack Surgery Syndrome followinglumbarspine surgery. Repeated surgeries lead to escalating costs and subsequent decreases in success rate.

2016:University of Minnesotas Department of Orthopedic Surgery inClinicoEconomics and outcomes research:

The 60% may be considered an improvement over results found in other studies. In a heavily cited 2006 landmark study from the Schulthess Clinic in Zurich Switzerland, doctors reported on 17 patientswith chronic low back pain, with a positive response to specific diagnostic tests for sacroiliac joint dysfunction who a bilateral sacroiliacfusion procedure.

At the time of follow-up (on average 39 months after surgery),

In the August 3, 2016 edition of the New York Times, author Gina Kolata wrote:

Back to MRI assessment

Is MRI to blame? Doctors at the Leiden University Medical Center in the Netherlandsquestioned whether or not MRI has any value in determining sciatica treatment or diagnosisand why surgeons rely so heavily on the readings.(5)We often see patients who visited the doctor who had unsupported enthusiasm for sacroiliac joint dysfunction surgery because they had an MRI showing a herniation between the L5 and S1 vertebrae and a prognosis of impending surgery.

Spinal Fusion Alternative: Regenerative medicine for problems of the spine

In a new paper Japanese doctors came up with a scoring system to help clinicians determine if sacroiliac joint pain was originating from the posterior longitudinal ligament of the spine.

The ligaments are important as attested to by researchers atUniversity of Mississippi Medical Center. As important as the vertebral ligaments are in maintaining the integrity of the spinal column and protecting the contents of the spinal canal, a single detailed review of their anatomy and function is missing in the literature.(7)

Why not get a consultation to see if the ligaments are the cause of your back pain before your embark on surgery?

The video below shows treatment of the low back with bone marrow derived stem cells. Compare this to surgery.

STEM CELL INSTITUTEA leading provider of bone marrow derived stem cell therapy, Platelet Rich Plasma and Prolotherapy in Los Angeles and the world!11645 WILSHIRE BOULEVARD SUITE 120, LOS ANGELES, CA 90025PHONE: (800) 300-9300

1: Gelalis ID, Papadopoulos DV, Giannoulis DK, Tsantes AG, Korompilias AV. Spinalmotion preservation surgery: indications and applications. Eur J Orthop Surg Traumatol. 2018 Apr;28(3):335-342. doi: 10.1007/s00590-017-2052-3. Epub 2017 Oct 6. Review. PubMed PMID: 28986691.

2. Shaffrey CI, Smith JS. Editorial: Stabilization of the sacroiliac joint. Neurosurg Focus. 2013 Jul;35(2 Suppl):Editorial. doi: 10.3171/2013.V2.FOCUS13273.

3 Polly DW, Cher D. Ignoring the sacroiliac joint in chronic low back pain is costly. ClinicoEconomics and Outcomes Research: CEOR. 2016;8:23-31. doi:10.2147/CEOR.S97345.

4 Schtz U1, Grob D. Poor outcome following bilateral sacroiliac joint fusion for degenerative sacroiliac joint syndrome. Acta Orthop Belg. 2006 Jun;72(3):296-308.

5.el Barzouhi A, Vleggeert-Lankamp CL, Lycklama Nijeholt GJ, Van der Kallen BF, van den Hout WB, Koes BW, Peul WC; Leiden-Hague Spine Intervention Prognostic Study Group. Predictive value of MRI in decision making for disc surgery for sciatica. J Neurosurg Spine. 2013 Dec;19(6):678-87. doi: 10.3171/2013.9.SPINE13349. Epub 2013 Oct 18.

6. Kurosawa D, Murakami E, Ozawa H, Koga H, Isu T, Chiba Y, Abe E, Unoki E, Musha Y, Ito K, Katoh S, Yamaguchi T. A Diagnostic Scoring System for Sacroiliac Joint Pain Originating from the Posterior Ligament.Pain Med. 2016 Jun 10. pii: pnw117. [Epub ahead of print]

7. Butt AM, Gill C, Demerdash A, Watanabe K, Loukas M, Rozzelle CJ, Tubbs RS. A comprehensive review of the sub-axial ligaments of the vertebral column: part I anatomy and function. Childs Nerv Syst. 2015 May 1.

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Stem Cell Joint Regeneration | Utah Stem Cells

Posted: July 26, 2018 at 3:48 pm

At Utah Stem Cells, our goal is to help as many patients as possible to become pain free and achieve substantially improved functionality. We feel that our approach to musculoskeletal pain and disability is distinct from other non-surgical approaches because we treat an important cause of these ailments that is often overlooked joint regeneration of damaged tissues and tightening of ligament laxity. Utah Stem Cells specializes in an advanced form of prolotherapy, which is a relatively unfamiliar and under-utilized non-surgical treatment for musculoskeletal disorders. Prolotherapy has been practiced for over 80 years by a small but growing group of physicians with great results. Experienced doctors using Prolotherapy have had great success in eliminating many forms of musculoskeletal pain for a very long time.

In fact, in 1957, a low back study published in the Journal of American Medical Association showed a cure rate of 82% with no recurrence of pain in a 14 year follow-up (http://jama.jamanetwork.com/article.aspx?articleid=1153924#References). This fact is even more impressive considering a recent study showed only 20% of all back surgeries are considered to be successful after 2 years, and 10-40% of patients suffer from long term complications from failed back surgery syndrome. Back surgery is the second-leading surgical procedure performed in the U.S. with approximately 500,000 surgeries performed annually.

Prolotherapy stimulates the body to repair the painful injured area(s) when the bodys natural healing process is not able to do the job on its own. Prolotherapy is an accurate injection of a non-toxic substance into the injured tissue, which causes a temporary and purposeful therapeutic inflammation. The resultant inflammation initiates a beneficial healing cascade causing an increase in blood supply, growth factors, and stem cells. This eventually produces an increase in collagen that essentially grows stronger tissues and cartilage.

Prolotherapy has the unique ability to treat not only the pain, but the cause of the pain. This results in permanent stabilization of the joint and, therefore, an end to pain and weakness-all without drugs, surgery, scar tissue, anesthesia or side effects.

Are the Injections Painful?

When done by a skilled practitioner, patients tolerate the procedure well. Because there is local anesthetic in the solution, patients may feel an initial relief of pain immediately following the treatment. As you may have read, Dr. Greenberg was able to self-administer his injections to heal himself of pain sustained from a car accident.

Because Prolotherapy induces inflammation, patients may experience a mild swelling and stiffness after treatments and should avoid any particularly heavy-duty exertion for the duration. Otherwise, they are able to pursue their normal lives and work schedules in between sessions.

How Long Until I See Results?

Each situation is unique and the length of treatment depends on a number of factors: nutritional status, ability to heal, overall health and the severity of the injury. Prolotherapy treatments are administered on an individual basis, every two to three weeks on average. Some patients may experience complete relief from pain and restoration of function after only one or two treatments.

In general, one single Stem Cell treatment is needed in all joints. In rare occasions a follow up PRP treatment might be beneficial to bring the patients pain level to 0. It can take up to six weeks after the injection for the body to complete the healing process. These are general estimates and actual healing time depends on the severity of the injury, the chronicity of the injury, and the persons individual genetics for healing.

Platelet Rich Plasma (PRP) is a revolutionary regenerative medicine procedure in which a substance derived from patients own blood is used to speed the healing and alleviate pain caused by a variety of musculoskeletal issues. This substance contains healing factors and bioactive proteins called growth factors and cell markers. These cells are vital for tissue regeneration and repair. With advanced techniques, we can concentrate and process these regenerative healing cells in a simple outpatient setting.

The PRP can be injected alone or in combination with Stem Cells. Ideally, the first Prolotherapy treatment employed for the treatment of a damaged joint would include the combination of Stem Cells with PRP. Subsequent treatments may be necessary, and these follow-up Prolotherapy treatments are usually with PRP alone.

How Does PRP Therapy Work?

During PRP therapy, a small sample of the patients blood is drawn (similar to a lab test sample) and placed in a centrifuge that spins the blood at high speeds, separating the platelets from other blood components. The process takes less than 15 minutes and increases the concentration of platelets and growth factors up to 500% greater than levels found in your own blood. The concentrated Platelet Rich Plasma is then injected into and around the point of injury, strengthening the bodys natural healing agent.

What Are The Benefits of PRP?

If you have a tendon or ligament injury, arthritic joint, meniscus tear, rotator cuff injury, shoulder pain, or bursitis and traditional methods have not provided relief, then PRP therapy may be the solution. The procedure is less aggressive and less expensive than surgery. It heals tissue with minimal to no scarring. PRP can alleviate further degeneration of tissues and can lessen the severity of arthritis. There is very little downtime or recovery time and patients can resume their normal daily activities almost right away.

The Physiological Effects of PRP Injections Include:

Stem Cell therapy is a highly effective treatment in which stem cells are injected into an injured area. Stem cells are responsible for rebuilding and regenerating the body. They are living cells that are able to transform themselves into many different types of tissue, and are therefore able to differentiate into ligaments, tendons, bone, nerve, and cartilage.

When an injury occurs, it is the stem cells that are released and summoned by the body to rebuild damaged muscle, joints or cartilage. By injecting these stem cells directly into the damaged area, the doctor is able to assist and accelerate the bodys natural healing process.

At Utah Stem Cells Dr. Bill Cimikoski uses the cells from Amniotic sac and Umbilical Cord cells from a healthy live birth. Amniotic stem cells are collected from the amniotic sac during a scheduled C-section, from a healthy baby with donor approval from the mother. Amniotic stem cells are multipotent, which means they have the potential to differentiate into several different kinds of cells in the body. Umbilical Cord blood stem cells are collected from the cord blood right after the birth of a healthy baby, also with the approval of the donor mother. Cord blood stem cells are biologically younger and are more flexible compared to adult stem cells. They have less risk of complications, and are immediately available and can minimize disease progression in early treatment.

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Stem Cell Joint Regeneration | Utah Stem Cells

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Journal of Stem Cell Research and Therapy- Open Access …

Posted: July 26, 2018 at 3:45 pm

PUBMED NLM ID: 101586297 | Index Copernicus Value: 84.95 The Journal of Stem Cell Research & Therapy is an open access journal that showcases seminal research in the field of stem cell therapy. As stem-cells are flag-bearers of translational research, the field has an interdisciplinary feel by including oncology, clinical research, medicine and healthcare under the aegis of stem-cell therapy. It also includes scientific research related to the auxiliary areas of Biology by prioritizing scholarly communication milieu and transfers expert knowledge synthesized from the ever burgeoning stem-cell literature. In order to create such impactful content, the Journal of Stem Cell Research & Therapy brings together an expert Editorial Board, which comprises of noted scholars in the field of Cell Biology. Every single article is subjected to rigorous peer review by illustrious scientists. In addition to Research Articles, the Journal also publishes high quality Commentaries, Reviews, and Perspectives aimed at synthesizing the latest developments in the field, and putting forward new theories in order to provoke debates amongst the scholars in the field. The journal thus maintains the highest standards in terms of quality and comprehensive in its approach.The journal aims to provide the authors with an efficient and courteous editorial platform. The authors can be assured of an expeditious publishing process. In this regard, the journal also provides advance online posting of the accepted articles. The Journal of Stem Cell Research & Therapy ensures barrier-free, open access distribution of its content online and thus, helps in improving the citations for authors and attaining a good impact factor.

Scholarly Journal of Stem Cell Research & Therapy is using online manuscript submission, review and tracking systems of Editorial Manager for quality and quick review processing. Review processing is performed by the editorial board members of Journal of Stem Cell Research and Therapy or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript.

It is an undifferentiated cell which is capable of transforming into more cells of same type or multiple other types. They are found in multicellular organisms. They can differentiate into cells of blood, skin, heart, muscles, brain etc. In adult human being, they replenish the dead cells of various organs. Stem cells are being used for treatment of various diseases like diabetes, arthritis, few cancers, bone marrow failure etc.

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They can develop into any cell type or organ in the body. A single totipotent stem cell can give rise to an entire organism. Fertilized egg or a zygote is the best example. Zygote divides and produces more totipotent cells. After 4 days the cells lose totipotency and become pluripotent.

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They can differentiate into any cell type in the human body. Embryonic stem cells are mostly pluripotent stem cells. They have the ability to differentiate into any of three germ layers: endoderm, mesoderm, or ectoderm.

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These are multipotent stem cells normally found in the bone marrow and are derived from mesenchyme. They differentiate into adipocytes, chondrocytes, osteoblasts, myocytes and tendon. MSCs can also be extracted from blood, fallopian tube, fetal liver and lungs.

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They are the multipotent stem cells derived from mesoderm and located in red bone marrow. They are responsible for production of red blood cells, white blood cells and platelets. HSCs give rise to myeloid lineage (which forms erythrocytes, eosinophils, basophils, neutrophils, macrophages, mast cells and platelets) and lymphoid lineage (which forms T-lymphocytes, plasma cells and NK cells).

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They can differentiate into more than one cell type, but only into a limited number of cell types. Hematopoietic stem cells are considered multipotent as they can differentite into red blood cells, platelets, white blood cells but they cannot differentiate into hepatocytes or brain cells.

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Cells with stem cell like abilities have been observed breast cancer, colon cancer, leukemia, melanoma, prostate cancer which can form new cells and lead to tumorigenesis. They cause relapse and metastasis by giving rise to new tumors. Scientists are developing methods to destroy CSCs in place of traditional methods which focus on bulk of cancer cells.

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They are derived from Hematopoietic stem cells. They differentiate into Erythrocyte progenitor cell (forms erythrocytes), Thrombocyte progenitor cell (forms platelets) and Granulocyte-Monocyte progenitor cell (forms monocytes, macrophages, neutrophils, basophils, eosinophils, dendritic cells).

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They are the self-renewing, multipotent stem cells in the nervous system that differentiate into neurons, astrocytes and oligodendrocytes. They repair the nervous system after damage or an injury. They have potential clinical use the management of Parkinsons disease, Huntingtons disease and multiple sclerosis.

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They are derived from embryo in the blastocyst stage. They are pluripotent stem cells. They give rise to all derivatives of the three primary germ layers: endoderm (stomach, colon, liver, pancreas, intestines etc.), mesoderm (muscle, bone, cartilage, connective tissue, lymphatic system, circulatory system, genitourinary system etc.) and ectoderm (brain, spinal cord, epidermis etc.).

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Embryonic stem cells are derived from the fetus are used in treatment of various diseases. As ESCs are pluripotent, they can differentiate into any cell type. Researchers are able to grow ESCs into complex cells types like pancreatic -cells and cardiocytes. Fetal cell therapy is generating lot of controversy from religious groups and ethics committees.

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Research is being done to use stem cells for the treatment of diabetes mellitus. Human embryonic stem cells may be grown in vivo and stimulated to produce pancreatic -cells and later transplanted to the patient. Its success depends on response of the patients immune system and ability of the transplanted cells to proliferate, differentiate and integrate with the target tissue.

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The procedure to replace damaged cells (in cancers, aplastic anemia etc.) with healthy stem cells of the same person or in another compatible person to restore the normal production of cells. It can either be autologous or allogeneic. Bone marrow HSCs are generally used for the transplantation.

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They are the totipotent, undifferentiated cells present in the meristems (shoot and root apices) of a plant. They never undergo aging process and can grow into any cell in the plant throughout its lifetime. They have numerous applications in production of cosmetics, perfumes, pigments, insecticides and antimicrobials.

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Several types of dental stem cells have been isolated from mature and immature teeth, exfoliated deciduous teeth and apical papilla, MSCS from tooth germs and from human periodontal ligament. They are found to be multipotent and can give rise to osteogenic, adipogenic, myogenic and neurogenic cell lineages.

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Adipose tissue is a huge source of mesenchymal stem cells which differentiate into various cell types. They can be easily extracted in large numbers by a simple lipo-aspiration. They have good application potential in regenerative medicine. ASCs are found to have the ability to differentiate into bone cells, cartilage cells, nerve cells, adipocytes etc.

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Preservation of stem cells is critical for both research and clinical application of stem-cell based therapies. Properly preserved stem cells can be later used in the field of regenerative medicine for treating congenital disorders, heart defects etc. Currently there is no universal method for preserving stem cells and the existing methods are expensive.

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MSCs can be applied in osteoarthritis treatment through implantation and microfracture as well as intra-articular injections. Single injection studies have showed improvement from pain which decreased overtime. Multiple, regular MSC injections into joints may be necessary.

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