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Hormone Replacement Therapy | HRT | Menopause | MedlinePlus

Posted: June 27, 2018 at 4:43 am

Menopause is the time in a woman's life when her period stops. It is a normal part of aging. In the years before and during menopause, the levels of female hormones can go up and down. This can cause symptoms such as hot flashes, night sweats, pain during sex, and vaginal dryness. For some women, the symptoms are mild, and they go away on their own. Other women take hormone replacement therapy (HRT), also called menopausal hormone therapy, to relieve these symptoms. HRT may also protect against osteoporosis.

HRT is not for everyone. You should not use HRT if you

There are different types of HRT. Some have only one hormone, while others have two. Most are pills that you take every day, but there are also skin patches, vaginal creams, gels, and rings.

Taking HRT has some risks. For some women, hormone therapy may increase their chances of getting blood clots, heart attacks, strokes, breast cancer, and gallbladder disease. Certain types of HRT have a higher risk, and each woman's own risks can vary, depending upon her health history and lifestyle. You and your health care provider need to discuss the risks and benefits for you. If you do decide to take HRT, it should be the lowest dose that helps and for the shortest time needed. You should check if you still need to take HRT every 3-6 months.

Food and Drug Administration

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Diabetes | Definition of Diabetes by Merriam-Webster

Posted: June 25, 2018 at 10:50 am

For them, other illnessesheart disease, cancer, diabetes, and Alzheimer's, each of which takes more livesoften eclipse the need for HIV/AIDS resources, Stevenson says.

The study led by researchers from Peking University Health Science Center was then narrowed down to people who did not have prior cancer, cardiovascular disease or diabetes.

City of Hope, the world-renowned independent research and treatment cancer for cancer, diabetes, and other life-threatening diseases, has appointed Evan Lamberg as the Music, Film and Entertainment Industry Boards new president.

But Zanos believes some conditions such as diabetes, rheumatoid arthritis, Crohns disease and chronic obstructive pulmonary disease could be monitored with nerve implants in the not-too-distant future.

Many of her patients are low-income Latinos, often with chronic issues: diabetes, heart disease, and high blood pressure.

Long-term studies have found that people who follow a Mediterranean-style diet are less likely to develop cardiovascular disease, diabetes, kidney disease and breast cancer, to name a few.

The links between obesity and heart disease, and between obesity and diabetes, have long dominated discussion of the health effects of excess weight.

Church's Harvard lab has worked through over 60 different therapies to modify two genes that act on four major diseases of aging (heart and kidney disease, obesity, and diabetes).

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Type 2 diabetes – Symptoms and causes – Mayo Clinic

Posted: June 25, 2018 at 10:50 am

Overview

Type 2 diabetes, once known as adult-onset or noninsulin-dependent diabetes, is a chronic condition that affects the way your body metabolizes sugar (glucose), your body's important source of fuel.

With type 2 diabetes, your body either resists the effects of insulin a hormone that regulates the movement of sugar into your cells or doesn't produce enough insulin to maintain a normal glucose level.

More common in adults, type 2 diabetes increasingly affects children as childhood obesity increases. There's no cure for type 2 diabetes, but you may be able to manage the condition by eating well, exercising and maintaining a healthy weight. If diet and exercise aren't enough to manage your blood sugar well, you also may need diabetes medications or insulin therapy.

Signs and symptoms of type 2 diabetes often develop slowly. In fact, you can have type 2 diabetes for years and not know it. Look for:

See your doctor if you notice any type 2 diabetes symptoms.

Type 2 diabetes develops when the body becomes resistant to insulin or when the pancreas stops producing enough insulin. Exactly why this happens is unknown, although genetics and environmental factors, such as excess weight and inactivity, seem to be contributing factors.

Insulin is a hormone that comes from the gland situated behind and below the stomach (pancreas).

Glucose a sugar is a main source of energy for the cells that make up muscles and other tissues.

In type 2 diabetes, this process doesn't work well. Instead of moving into your cells, sugar builds up in your bloodstream. As blood sugar levels increase, the insulin-producing beta cells in the pancreas release more insulin, but eventually these cells become impaired and can't make enough insulin to meet the body's demands.

In the much less common type 1 diabetes, the immune system destroys the beta cells, leaving the body with little to no insulin.

Researchers don't fully understand why some people develop type 2 diabetes and others don't. It's clear, however, that certain factors increase the risk, including:

Type 2 diabetes can be easy to ignore, especially in the early stages when you're feeling fine. But diabetes affects many major organs, including your heart, blood vessels, nerves, eyes and kidneys. Controlling your blood sugar levels can help prevent these complications.

Although long-term complications of diabetes develop gradually, they can eventually be disabling or even life-threatening. Some of the potential complications of diabetes include:

Healthy lifestyle choices can help you prevent type 2 diabetes. Even if you have diabetes in your family, diet and exercise can help you prevent the disease. If you've already received a diagnosis of diabetes, you can use healthy lifestyle choices to help prevent complications. And if you have prediabetes, lifestyle changes can slow or halt the progression from prediabetes to diabetes.

Sometimes medication is an option as well. Metformin (Glucophage, Glumetza, others), an oral diabetes medication, may reduce the risk of type 2 diabetes but healthy lifestyle choices remain essential.

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced. See the stories of satisfied Mayo Clinic patients.

Jan. 03, 2018

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Dog Diabetes Symptoms, Diagnosis, and Treatment – WebMD

Posted: June 25, 2018 at 10:50 am

WebMD Veterinary Reference from ASPCA Virtual Pet Behaviorist In this Article In this Article In this Article

Diabetes in dogs is a complex disease caused by either a lack of the hormone insulin or an inadequate response to insulin.

After a dog eats, his digestive system breaks food into various components, including glucose-which is carried into his cells by insulin, a hormone secreted by the pancreas. When a dog does not produce insulin or cannot utilize it normally, his blood sugar levels elevate. The result is hyperglycemia, which, if left untreated, can cause many complicated health problems for a dog.

It is important to understand, however, that diabetes is considered a manageable disorder-and many diabetic dogs can lead happy, healthy lives.

Diabetes can be classified as either Type 1 (lack of insulin production) or Type II (impaired insulin production along with an inadequate response to the hormone.)

The most common form of the disease in dogs is Type 1, insulin-dependent diabetes, which occurs when the pancreas is incapable of producing or secreting adequate levels of insulin. Dogs who have Type I require insulin therapy to survive. Type II diabetes is found in cats and is a lack of normal response to insulin.

The following symptoms should be investigated as they could be indicators that your dog has diabetes:

The exact cause of diabetes is unknown. However, autoimmune disease, genetics, obesity, chronic pancreatitis, certain medications and abnormal protein deposits in the pancreas can play a major role in the development of the disease.

It is thought that obese dogs and female dogs may run a greater risk of developing diabetes later in life (6-9 years of age). Some breeds may also run a greater risk, including Australian terriers, standard and miniature schnauzers, dachshunds, poodles, keeshonds and samoyeds. Juvenile diabetes can also be seen and is particularly prevalent in golden retrievers and keeshonds.

In order to properly diagnose diabetes, your veterinarian will collect information about your dogs clinical signs, perform a physical examination and check blood work and a urinalysis.

Diabetes treatment is based on how severe the symptoms and lab work are and whether there are any other health issues that could complicate therapy. Each dog will respond a little bit differently to treatment, and therapy must be tailored to the individual dog throughout his life.

Your vet may also show you how to perform glucose tests at home.

As your veterinarian will explain, its important to always give your dog insulin at the same time every day and feed him regular meals in conjunction with his medication. This allows increased nutrients in the blood to coincide with peak insulin levels, and will lessen the chance that his sugar levels will swing either too high or too low. You can work with your vet to create a feeding schedule around your pets medication time. It is also important to avoid feeding your diabetic dog treats that are high in glucose. Regular blood glucose checks are a critical part of monitoring and treating any diabetic patient, and your veterinarian will help you set up a schedule for checking your dogs blood sugar.

Please also consult your vet about a consistent, daily exercise program and proper nutrition for your dog to help keep his weight in check.

Although a certain form of diabetes-the type found in dogs less than a year of age-is inherited, proper diet and regular exercise can be very effective in helping to prevent onset of diabetes in older dogs. Aside from other negative health effects, obesity is known to contribute to an ability to respond normally to insulin.

If your dog is showing any of the clinical signs listed above, please see your veterinarian right away.

If diabetes progresses without being treated, dogs can develop secondary health problems like cataracts and severe urinary tract problems. Ultimately, untreated diabetes can cause coma and death.

WebMD Veterinary Reference from ASPCA Virtual Pet Behaviorist

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10 Warning Signs of Diabetes – Frequent Urination

Posted: June 25, 2018 at 10:50 am

Diabetes, short for diabetes mellitus, refers to a variety of metabolic disorders that cause high blood sugar levels over a protracted period of time. They occur either due to inefficient insulin production by the pancreas or to an inability by cells to react properly to the insulin that is released. Unfortunately, there is no current cure for diabetes, and treatment only seeks to prevent the various symptoms as well as the medical complications associated with the disease. The earlier it is detected, the sooner one may be able to begin treatment for diabetic woes. For the purpose of early detection, the following signs are what one must watch out for.

The condition of diabetes causes the sugar content of the blood to rise above normal levels. This requires the patients kidneys to work harder than usual, so that the excess sugar can be removed successfully. This overtime work results in the formation of excess urine, causing the person to have frequent urges to urinate. Such a condition isnt just distracting, it can also lead to kidney damage and eventually kidney failure in case no treatment is undertaken. Frequent urination can hence be a very significant warning of diabetes and should be reported to a physician if prolonged.

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Home | Rhode Island Blood Center

Posted: June 25, 2018 at 10:47 am

Can I donate?

Many people think they cannot donate blood before they even try. That's often because of myths like being too old, taking medications, or having a physical condition that prevents donation. In most cases, it's not true!More often than not, you can donate even if you've recovered from a heart attack, cancer,have diabetes, or are taking many different types of medications.Get the facts. Our medical team can also confidentially answer specific questions you have about donating.

For a small state, there are plenty of opportunities to save lives. We have six blood donation centers conveniently located throughout Rhode Island. Each offers maximum donor comfort, including comfortable donation lounge chairs, TV, free WIFI and parking. The state-of-the-Art automated blood donation technology allows donors to give just the part of their blood -- red cells, platelets or plasma -- patients need the most based on the donor's blood type. In addition, we hold over 1,000 mobile blood drives out in the community each year.

Over 370,000 people in Rhode Island are eligible to give blood, but only about 5% of the population actually donates. Giving life through blood and stem cell donations uniquely comes from you and yourwillingness to roll up your sleeveto donate blood,register to BeTheMatch andsponsor drives.

The one thing each donor experience has in common is the amazing feeling of knowing youjust gave someone else a second chance at life. More than time or money, you are donating your lifeblood, a part of you that provides strength, energy and vitality to another human being in need.

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Genetic Engineering Will Change Everything Forever …

Posted: June 25, 2018 at 10:46 am

Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. The only thing we know for sure is that things will change irreversibly.

Support us on Patreon so we can make more videos (and get cool stuff in return): https://www.patreon.com/Kurzgesagt?ty=h

Kurzgesagt merch here: http://bit.ly/1P1hQIH

Get the music of the video here:

soundcloud: http://bit.ly/2aRxNZdbandcamp: http://bit.ly/2berrSWhttp://www.epic-mountain.com

Thanks to Volker Henn, James Gurney and (prefers anonymity) for help with this video!

THANKS A LOT TO OUR LOVELY PATRONS FOR SUPPORTING US:

Jeffrey Schneider, Konstantin Kaganovich, Tom Leiser, Archie Castillo, Russell Eishard, Ben Kershaw, Marius Stollen, Henry Bowman, Ben Johns, Bogdan Radu, Sam Toland, Pierre Thalamy, Christopher Morgan, Rocks Arent People, Ross Devereux, Pascal Michaud, Derek DuBreuil, Sofia Quintero, Robert Swiniarski, Merkt Kzlrmak, Michelle Rowley, Andy Dong, Saphir Patel, Harris Rotto, Thomas Huzij, Ryan James Burke, NTRX, Chaz Lewis, Amir Resali, The War on Stupid, John Pestana, Lucien Delbert, iaDRM, Jacob Edwards, Lauritz Klaus, Jason Hunt, Marcus : ), Taylor Lau, Rhett H Eisenberg, Mr.Z, Jeremy Dumet, Fatman13, Kasturi Raghavan, Kousora, Rich Sekmistrz, Mozart Peter, Gaby Germanos, Andreas Hertle, Alena Vlachova, Zdravko aek

SOURCES AND FURTHER READING:

The best book we read about the topic: GMO Sapiens

https://goo.gl/NxFmk8

(affiliate link, we get a cut if buy the book!)

Good Overview by Wired:http://bit.ly/1DuM4zq

timeline of computer development:http://bit.ly/1VtiJ0N

Selective breeding: http://bit.ly/29GaPVS

DNA:http://bit.ly/1rQs8Yk

Radiation research:http://bit.ly/2ad6wT1

inserting DNA snippets into organisms:http://bit.ly/2apyqbj

First genetically modified animal:http://bit.ly/2abkfYO

First GM patent:http://bit.ly/2a5cCox

chemicals produced by GMOs:http://bit.ly/29UvTbhhttp://bit.ly/2abeHwUhttp://bit.ly/2a86sBy

Flavr Savr Tomato:http://bit.ly/29YPVwN

First Human Engineering:http://bit.ly/29ZTfsf

glowing fish:http://bit.ly/29UwuJU

CRISPR:http://go.nature.com/24Nhykm

HIV cut from cells and rats with CRISPR:http://go.nature.com/1RwR1xIhttp://ti.me/1TlADSi

first human CRISPR trials fighting cancer:http://go.nature.com/28PW40r

first human CRISPR trial approved by Chinese for August 2016:http://go.nature.com/29RYNnK

genetic diseases:http://go.nature.com/2a8f7ny

pregnancies with Down Syndrome terminated:http://bit.ly/2acVyvg( 1999 European study)

CRISPR and aging:http://bit.ly/2a3NYAVhttp://bit.ly/SuomTyhttp://go.nature.com/29WpDj1http://ti.me/1R7Vus9

Help us caption & translate this video!

http://www.youtube.com/timedtext_cs_p...

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Maryland Stem Cell Research Fund: 2014 Awardees

Posted: June 24, 2018 at 10:42 am

2018 Awardees

Round 2

Clinical Grant Recipient:

Dr. Luis Garza

Johns Hopkins University - Stem Cell Therapy to Convert Stump Skin to Palmo-Plantar Skin in Amputees

Dr. Anthony Oliva

Longeveron, LLC - Longeveron Mesenchymal Stem Cells (LMSCs) to Improve Vaccine Response in Aging Frailty

Commercialization Grant Recipient:

Dr. Luiz Alvarez

Theradaptive, Inc. - Development of a Biphasic MSC Delivery System for the Repair of Osteochondral Defects

Validation Grant Recipients:

Dr. Warren Grayson

Johns Hopkins University - Oxygen-Delivering BiO2-Bone Scaffolds for Regenerating Vascularized Craniofacial Bone

Dr. Tonya Webb

University of Maryland, Baltimore - Convertible Natural Killer T cells for Immunotherapy

Discovery Grant Recipients:

Dr. Samarjit Das

Johns Hopkins University - Design and Use of Human Pluripotent Stem Cell Bioreactors in Myocardial Preservation

Dr. Valina Dawson

Johns Hopkins University - Neurotoxic Astrocytes in Neurodegeneration

Dr. Ricardo Feldman

University of Maryland, Baltimore - Targeting a Novel Lysosomal Sphingolipid-Sensing Mechanism for Reversal of GBA1-Associated Neurodegeneration

Dr. Xiaofeng Jia

University of Maryland, Baltimore - Novel 3D Bioprinted Scaffolds to Promote Neural Crest Stem Cell Mediated Nerve Regeneration

Dr. Minjung Kim

University of Maryland, Baltimore - Reducing RAB GTPase14 to Drive in Vitro Human Erythropoiesis

Dr. Gabsang Lee

Johns Hopkins University - Optically-Induced VEFG Activation in Human Endothelial Cells

Dr. Rachana Mishra

University of Maryland, Baltimore - Mesenchymal Stem Cells Preserve Right Ventricular Function in a Neonatal Swine Model of Pressure Overload by Releasing GDF15 and miR-132 Enriched Exosomes

Dr. Satoru Otsuru

University of Maryland, Baltimore - Developing MSC-Derived Extracellular Vesicle Therapy for Osteogenesis Imperfecta

Dr. Pankaj Pasricha

Johns Hopkins University - Identification and Isolation of the Human Enteric Neural Stem Cell: Laying Foundation for Curing Achalasia

Dr. Arun Venkatesan

Johns Hopkins University - A Human Stem Cell-Derived Sensory Neuron Model of VZV Infection

Dr. Hilary Vernon

Johns Hopkins University - Development of an iPSC Derived Cellular Model of Barth Syndrome:

Towards Novel Therapeutic Discovery

Dr. Jiou Wang

Johns Hopkins University - A Novel 3D Microphysiological Brain Model for Studying Neurodegenerative Disease ALS/FTD

Post-Doctoral Fellowship Grant Recipients:

Dr. Adriana Blazeski

Johns Hopkins University - Study of Arrhythmogenic Cardiomyopathy Using a Syncytial Model of hiPSCs

Dr. Muthukumar Gunasekaran

University of Maryland, Baltimore - Donor Derived Exosomes as Non-Invasive Serum Biomarker for Immune Rejection Following Human Neonatal Cardiac Progenitor Cell Transplantation

Dr. Kenji Johnson

Johns Hopkins University - Use of 3D Minibrain Organoids for Studying C9orf72 ALS/FTD Disease Mechanisms

Dr. Minseong Kim

Johns Hopkins University - Modeling of Parkinsons Disease using PD-Patients iPSCs-Derived Dopaminergic Neurons with Optical Controllable Alpha-Synuclein

Dr. Mehreen Kouser

Johns Hopkins University - Manganese-Enhanced MRI For Interrogating Astrocyte Replacement in A Mouse Model of ALS

Dr. Su Chan Lee

Johns Hopkins University - Generation of Cancer Progression Models through New Optogenetic Tool to Control p53 in iPSCs

Dr. Seungman Park

Johns Hopkins University - Functional Property Evaluation of iPSC-Derived Cardiac Tissues for Optimized Heart Disease Treatment

Dr. Wei Zhu

Johns Hopkins University - 3D Vascularized Hydrogel Scaffold to Carry Stem Cells for Traumatic Brain Injury Repair

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Excellence in Stem Cell Research | University of Maryland …

Posted: June 24, 2018 at 10:42 am

The secret ingredient behind the next revolution in medicine lies within each of us. Special cells in our bodies, called stem cells, have the ability to both extensively self-renew and, through a series of highly complex molecular events, turn themselves into all of the unique cells found in the human body. Scientists harnessing this remarkable latter ability, referred to as pluripotency, are using stem cells to repair or regenerate damaged tissues and organs, providing potential treatments for diseases such as Alzheimers and Parkinsons disease, diabetes, heart disease, stroke, arthritis, and cancer. In addition, stem cells can be used to create specialized tissues to test out drugs before prescribing them to humans.

Scientists are also using stem cells to learn how the human body is made and why some cells develop abnormally and lead to problems such as birth defects and cancer. Because stem cells eventually differentiate into mature cells that have specific jobs to do, they are actually quite rare in adults, meaning that the stem cells that scientists and clinicians work with are often donated from embryos. Therefore, another intense aspect of investigation is learning how to derive fully functional stem cells from adult cells.

The University of Maryland School of Medicine has quickly become a leader in the field of stem cell research. The Center for Stem Cell Biology and Regenerative Medicine opened in 2009 with the recruitment of Curt I. Civin, M.D., as its founding director. The mission of the Center is to bring together the scientific and clinical expertise necessary to discover how stem cells work and translate that knowledge into therapies for a wide variety of human diseases.

The Center is working towards several specific goals: developing a highly collaborative and interdisciplinary research environment; encouraging rapid translation of discoveries into innovative and practical clinical applications that will enhance the understanding, diagnosis, treatment, and prevention of human diseases; collaborating with pharmaceutical and biotechnology companies to stimulate investment and local economic growth; educating the local community about stem cell research; and advocating for the State of Marylands continuing support of stem cell research.

Capabilities

The Center operates two collaborative activities that act in tandem to fuel stem cell research by enhancing stem cell production and facilitating their transition into numerous cell types.

The first collaborative activity grows a variety of stem cells from multiple species, particularly embryonic stem cells and induced pluripotent stem cells, which are cells that can be genetically reprogrammed to behave like embryonic stem cells. Scientists from the University of Maryland, the National Institutes of Health, other universities and a myriad of biotechnology companies, will be able to expedite their research through access to the stem cells grown by this collaboration.

In our bodies, stem cells are very, very rare, says Civin. When we take them out and try to grow them in dishes, they prefer to die. Their second preference is to differentiate so theyre no longer stem cells. If theyre going to be used as therapeutic cells, or even used for research, wed like to be able to grow up lots and lots of them.

In the second collaborative activity, stem cells are modified genetically, providing scientists models for many different diseases. Cells are engineered to increase or decrease their production of certain molecules, a painstaking process that enables detailed mechanistic studies of cell function.

Researchers

More than 70 faculty scientists and physicians at University of Maryland contribute to the achievement of the Centers goals. In addition to the University of Maryland School of Medicine, members of the Center are affiliated with special laboratories, programs, and schools throughout the University of Maryland system. Faculty members are split into four Working Groups:

Scientific Highlights

Dr. Sunjay Kaushal uses stem cells removed during heart reconstruction surgery in children to treat patients who have suffered heart attacks, heart failure and congenital heart disease.

Dr. Ricardo Feldman is working to generate patient-specific induced pluripotent stem cells (iPSCs) for modeling and treating Gauchers disease, Parkinsons disease, and other neurodegenerative diseases.

Dr. Curt Civin is using next-generation gene editing in an effort to discover a cure for sickle cell anemiaone of the most common genetically inheritable diseases.

Collaborations

The Center has struck up a collaborative agreement between Maryland and California, two states at the forefront of stem cell research, to pool resources to help scientists in both states share their talents and discoveries.

The Center also collaborates closely with local biotechnology companies, such as Paragon Bioservices, Inc., one of the largest companies in the University of Marylands BioPark. Paragon worked with the Center to facilitate the research, commercial development and clinical application of stem cell-based technologies and therapies.

Weve been pushing the envelope on interacting with industry, says Civin. We go first to Maryland companies. We can go out and visit them, instead of just emailing and talking long distance about the process. Then we can do the first few experiments together in person to make sure were doing things right from the start.

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Stem Cell Therapy in Colorado | Aspen Integrative Medicine

Posted: June 23, 2018 at 12:46 am

By definition, stem cells are undifferentiated biological cells that can differentiate into specialized cells and divide to produce more stem cells. There are three ways adult stem cells can be obtained: from bone marrow, adipose tissue, or blood.

Unlike embryonic stem cells, the use of adult stem cells in research and therapy is not considered to be controversial, as they are derived from adult tissue samples rather than discarded human embryos. By law, these adult stem cells have to be injected or infused into the patient within 24 hours after being obtained.

Adult stem cells have the ability to divide and generate all cell types of the organ from which they originate. They possess two properties: self-renewal and multi-potency, meaning they can go through numerous cycles of cell division while still maintaining their undifferentiated state. Stem cells hold the ability to generate into several distinct cell types, including neural cells found in the brain.

Regenerative stem cell therapy can stimulate tissue re-growth and greater blood flow to the affected areas.* The goal of treatment with stem cells is to replace damaged cells and to promote the growth of new blood vessels and tissues in order to help the target organ function at a greater capacity.*

*Results may vary; no guarantee of specific results

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