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Integrative Medicine & Wellness Center – Morristown NJ

Posted: August 25, 2017 at 6:43 am

Integrative medicine is beneficial for people who want to maintain good health, as well as those who are looking to improve their current health. Evidence-based studies have shown that integrative medicine therapies reduce pain and anxiety, enhance healing, speed recovery, and promote feelings of peace and relaxation.

The Chambers Center for Well Being offers more than 20 different healing treatments, including holistic health assessments, nutritional assessments and counseling, lifestyle coaching, acupuncture and massage. Our experts can help you address current health concerns or work with you to prevent health issues such as high blood pressure and cholesterol, weight issues, stress and more.

Our outpatient services are available at two New Jersey locations, including Summit and Morristown, and one physician practice in Morristown.

See all videos about our outpatient services >

Atlantic Health System Integrative Medicine offers free bedside services throughout our hospitals, including therapeutic massage for new moms, acupressure, reflexology, aromatherapy, relaxation techniques and guided imagery. These services are for maternity, cardiac, orthopedic, pediatric, ICU, emergency room and all other patients throughout our hospitals.

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Harvard’s Continued Embrace of Integrative Medicine Finds a Partner and a New Conflict of Interest – American Council on Science and Health

Posted: August 25, 2017 at 6:43 am

The Osher Center for Integrative Medicine, Harvards outreach into complementary medicine recently announced a partnership where three researchers associated with the Harvard Osher Center will each summarize a top recent publication from the burgeoning mind-body literature and provide commentary on why they chose to shine a light on it. Harvard is not alone in this effort. Just Tuesday Wolters Kluver announced Ovid Insights,a current awareness service, citing the exponentially expanding volume of research.

As the volume of research worldwide continues to increase, staying current on the latest medical findings and practice guidelines is an overwhelming, yet necessary, task for healthcare professionals.

Ironically, the academics first filled, in the sense of a firehouse filling a cup, the journals with studies predicated on the concept of publish or perish. And having overwhelmed our attention, they now introduce a solution, the era of curated journal reading.

Harvards collaborative partner is the Journal of Alternative and Complementary Medicine (JACM) considered to be in the top quartile of journals covering this area. To give you a sense of the journals academic reach you might considertwo reported measures of citation rates. The SJR, a size independent measure of scientific influence is 0.581, for comparison, the New England Journal of Medicine's (NEJM) is 17.736. The SJR puts JACM 17th among their peers (96 journals) after the Journal of Natural Products and Journal of Ginseng Research. Citations per document reflect how often a journal is cited; it is a commonly used measure of the journals impact on research. Here JACM has a value of 1.537 (the NEJM is 33.902) placing it 22nd amongst its peers, just after Chiropractic and Manual Therapies but before Chinese Medicine [1]

The three Harvard faculty members [2], all JACM associate editors, select a theme and then choose one study from the literature to abstract and to comment upon. I read the articles they presented, while they are a bit too touchy feely for me, and have the usual problems that plague the literature (small sample size, p-hacking, and data mining), they were all thoughtful articles to read and consider. My concern was the descriptions of studies within their abstracts, for example:

Cherkin and colleagues' beautiful randomized prospective studyThis powerful study demonstrates

In an elegantly designed and rigorously conducted comparative effectiveness trial supported by the National Center for Complementary and Integrative Health (NCCIH)/National Institutes of Health (NIH)

Stephen Ross and colleagues conducted a small but methodologically elegant double-blind, placebo-controlled, crossover trial

Perhaps it is me, but I detect a tone of advocacy, and with advocacy comes conflicted interests. I have no issue with knowledgeable people suggesting reading, but there is a fine line between organizing and sorting of information dispassionately and content curation that is, an editorial process. It's a mix of art and science. It requires a clear and definable voice,and editorial mission,and an understanding of your audience and community.[3] Can we reliably expect these academics to cite articles that do not favor alternative and complementary medicine? So far, in the year of this collaboration, no article they have chosen has taken an unfavorable view. Are the Harvard faculty acting as fair witness or advocates, do they shed light or only increase the echo? The goals of JACMs editor, John Weeks, JACMs editor, provides additional clues when he states that his goal that JACM becomes an arbiter of the conversation and content that shapes the course of healthcare. Perhaps I am mistaken, but I want my journals to provide me with unbiased research so that I can form my own view and be the arbiter of my conversations.

[1] The SCImago Journal & Country Rank is a publicly available portal that includes the journals and country scientific indicators [that] can be used to assess and analyze scientific domains.

[2] Osher Center's Director of Research Peter Wayne, PhD, Gloria Yeh, MD, MPH, Research Fellowship Director, and Darshan Mehta, MD, MPH, the center's Director of Education

[3] Is Curation Overused? The Votes Are In

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UA integrative medicine residency program flourishes – Sierra Vista Herald

Posted: August 25, 2017 at 6:43 am

TUCSON Faculty at the University of Arizona Center for Integrative Medicine and their collaborators successfully demonstrated the feasibility and effectiveness of an online approach to train more family medicine residents in integrative medicine.

The American Board of Physician Specialties defines integrative medicine "as the practice of medicine that reaffirms the importance of the relationship between practitioner and patient, focuses on the whole person, is informed by evidence, and makes use of all appropriate therapeutic approaches, healthcare professionals and disciplines to achieve optimal health and healing."

Effective online training in integrative medicine is important given the increased demand for physicians with expertise in integrative medicine coupled with the call from medical and public health organizations for alternatives to traditional medical approaches to such matters as pain management.

With that in mind, Dr. Patricia Lebensohn, professor of Family and Community Medicine at the UA College of Medicine-Tucson, directed the development of an Integrative Medicine in Residency program, a robust, online curriculum with the aim of establishing integrative medicine as a routine part of family medicine residency education throughout the country.

An in-depth evaluation of the project and its results was published in the July-August 2017 issue of the journal Family Medicine.

The study tested a 200-hour online curriculum, at eight sites offering integrative medicine residencies across the United States. Study subjects included 186 family medicine residents who participated in the IMR and 53 residents in other programs without integrative medicine training who served as controls.

Of the 186 IMR residents, 77 percent completed the program and tested significantly higher in their medical knowledge of integrative medicine than the control residents.

"Despite how busy the residents were, there was a very high completion rate," says Dr. Victoria Maizes, executive director of UACIM. "The level of knowledge improves in those who complete the curriculum and doesn't change in those who don't."

"When we started this study in 2008, it was a novel idea to deliver common curriculum online across eight sites," says Maizes. "This curriculum is now shared at 75 residencies and has expanded well beyond family medicine. We started with this project in family medicine. Now, we're in pediatrics, internal medicine, preventive medicine and we have a pilot program in psychiatry."

"I am pleased with the results of the residents' evaluation of the high clinical utility of the curriculum and the ease of navigating the online delivery," says Lebensohn. "Most of the residents in an exit survey stated that they intend to utilize integrative medicine approaches in their future practice of family medicine."

Additional study authors included Audrey J. Brooks and Paula Cook, UA; Dr. Benjamin Kligler, Icahn School of Medicine at Mount Sinai; Dr. Raymond Teet, Albert Einstein School of Medicine, New York; and Dr. Michele Birch, Carolinas Medical Center, Charlotte, North Carolina.

Submitted by the University of Arizona Communications

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Top UCSD researchers pitch yoga, massage and integrative … – The San Diego Union-Tribune

Posted: August 25, 2017 at 6:43 am

She wielded a kitchen knife, not a scalpel, but Serena Silberman was doing her part Saturday to heal the human body, one chop of parsley, peach and pomegranate at a time.

Food can be medicine, said Silberman, an instructor at the University of California San Diego Integrative Medicine Natural Healing Cooking Program, as she prepped a meal for more than 200 people at the Sanford Consortium for Regenerative Medicine in La Jolla.

Her feast was to commemorate the debut of UC San Diegos Centers for Integrative Health, an initiative throughout the university and health network to unify current research, education and clinical programs ranging from nutrition and acupuncture to meditation and yoga.

Saturdays all-day conference rang in the new collaborative health effort at UC San Diego by discussing how western science can be better wedded to traditional folk cures and alternative medicine to offer better outcomes for patients.

Charlie Neuman/U-T

At the Sanford Consortium, UC San Diego on Saturday launched the new Centers for Integrative Health. At the beginning of the event attendees participate in meditation.

At the Sanford Consortium, UC San Diego on Saturday launched the new Centers for Integrative Health. At the beginning of the event attendees participate in meditation. (Charlie Neuman/U-T)

To Silberman, that means parsley. Rich in antioxidants, the green leaves naturally contain the anti-inflammatory luteolin; Vitamin A to boost the white blood cells that attack infection; and folate, which can help protect patients from heart attack, stroke and hardened arteries.

And then theres her generous dusting of turmeric, the orange-colored herb from the ginger family that doubles as a curry spice and dye. Researchers are studying whether it might heal heart disease and diabetes with very few side effects.

Indian cooks have only been doing it for 5,000 years, so they might know something, said Silberman, punctuating her point with the chop-chop-chop of peaches.

None of this is new to UC San Diego. The Center for Integrative Medicine, for example, was established seven years ago and now treats more than 10,000 patients annually, but organizers hope future consultations will seamlessly involve the Centers for Mindfulness, Integrative Research, Integrative Nutrition and Integrative Education into a one-stop experience.

That means 26 practitioners in 10 clinics within eight departments throughout the health system will be integrated.

Dr. Dan Slater, a physician and UC San Diego professor of family medicine and public health, presented to a packed Sanford Consortium audience a case study he thinks might guide future patient care.

Charlie Neuman/U-T

Attendees to the launch of UC San Diego's Centers for Integrative Health get acupuncture and massages while listening to therapeutic harp music by Carolyn Worster.

Attendees to the launch of UC San Diego's Centers for Integrative Health get acupuncture and massages while listening to therapeutic harp music by Carolyn Worster. (Charlie Neuman/U-T)

A 61-year-old woman was suffering from symptoms suggesting ulcerative colitis, a painful inflammatory bowel disease. The wait had grown to six months in her small town for a colonoscopy that peeked at the lining of her intestine and took a sample of the tissue, a procedure Slater noted was not cheap and was not necessarily convenient.

So he and his team of integrative health specialists prescribed a diet high in fiber, fruits and vegetables and low in fats and sweets. A little more turmeric and a few dollops of probiotics good bacteria to boost the digestive system and within three months she was feeling better. By the time her colonoscopy rolled around, her condition was either in remission or cured.

To Slater, that highlights what the Centers for Integrative Health might do best researching many pathways to a cure but letting the body do most of the work by exploring everything from aromatherapy to zen.

cprine@sduniontribune.com

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Integrative medicine physicians say quality of life is better – FierceHealthcare

Posted: August 25, 2017 at 6:43 am

Physicians practicing integrative medicine have improved quality of life and spend more time with their patients, according to a new survey.

The study, conducted by Pure Branding, a market research company, looked at why doctors leave conventional practices for integrative medicine, which pairs standard treatments with complementary therapies to care for a patients mind, body and spirit. The study included 1,133 integrative medical doctors and doctors of osteopathyfrom 49 states.

As more doctors report burnout, which has increased by 25% in just four years, a rapidly growing number of doctors are exploring integrative approaches to clinical care. The study identified five factors that define integrative medicine:

These ... doctors are at the forefront of a paradigm shift in medicine that will significantly impact the value chain from healthcare systems and payers to medical schools and suppliers, said Yadim Medore, founder and CEO of Pure Branding.

RELATED: Alternative medicine becomes a lucrative business for U.S. top hospitals

Some of the findings from the survey included:

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People on the Move – Utah Business

Posted: August 25, 2017 at 6:43 am

Pleasant GrovedoTERRA, the worlds leading global essential oils company, is pleased to announce the appointment of Dr. Brannick Riggs to its corporate administration team as vice president of healthcare initiatives and chief medical director of doTERRAs medical clinic. Riggs, who has served on doTERRAs medical advisory board for five years, will continue to practice medicine while advancing the work doTERRA has already begun in research and healthcare in this newly created position. While serving on the companys medical advisory board, Dr. Riggs made major contributions to doTERRAs research and education initiatives. Prior to joining doTERRA, Dr. Riggs taught as an associate professor at the University of Utah College of Medicine, practiced as a physician and partner at Revere Health, and served as Revere Healths Medical Director of the Northern Utah Region. He graduated from the University of Arizona College of Medicine. While studying at Arizona, he received training in integrative medicine under Dr. Andrew Weil, an internationally recognized expert in this field. He is passionate about marrying modern medicine with essential oils, proper nutrition, and exercise. He enjoys using essential oils in his personal and family life, teaching individuals and healthcare professionals about them, and conducting research in this field.

Salt Lake CityNewmark Grubb ACRES (NGA) is excited to welcome the Summit Senior Housing Advisors (SSHA) group, McSean Thompson and Sam Bechthold. SSHA are industry leaders in senior housing investment sales in the Intermountain West and will play a critical role in furthering the success of Newmarks market-leading investment division. McSean has consulted with dozens of operators on how to implement operational improvements and has closed over $75 million in transactions in the last 36 months. He has extensive experience in data science and analytics, having completed a five-year engagement with the Ministry of Higher Education and Scientific Research in the United Arab Emirates; he became passionate about caring for the senior population while volunteering at a senior housing facility while pursuing his undergraduate degree at Brigham Young University. Bechthold is a healthcare real estate professional with a wide range of experience in brokerage, asset management and senior housing operations including business development and investment analysis. Sam got his start in healthcare real estate management as a senior investment analyst and asset manager at Welltower (formerly Health Care REIT), where he was responsible for an $865 million portfolio of senior housing assets. He received a masters degree in real estate finance and development from Cornell University and earned his undergraduate degree at the University of Utah.

Salt Lake CitySpectrum Engineers is pleased to welcome Vellachi Ganesan as their new lighting designer. In addition to being an architectural lighting designer, Ganesan is a light artist and design educator. She studied architecture (BA) in Singapore and Paris, and architectural lighting design (MSc) in Stockholm. Ganesan has worked for eight years within the lighting design industry. Her experience includes working as a lighting designer for Arup, presenting award winning light-art installations at international festivals and teaching lighting design to Architecture and Multi-Disciplinary Design students in renown tertiary institutions. Ganesan believes in working collaboratively across disciplines with architects, designers and artists to create work that is meaningful to the human being. Her work has received notable recognition, including the Special Commendation Award (Special Projects) at the prestigious Lighting Design Awards (London) in 2012.

Salt Lake CitySnell & Wilmer is pleased to announce that Salt Lake City attorney Braden Johnson has been nominated to Needs Beyond Medicine board of directors. In addition to his service as a director, Johnson will also assist as the corporate secretary. Needs Beyond Medicine is a nonprofit organization whose mission is to decrease the burden of cancer by increasing awareness, education and relief to cancer patients. Needs Beyond Medicines primary focus is to assist in enhancing the quality of life for those diagnosed with cancer through educational and financial support. At Snell & Wilmer, Johnson focuses his practice in commercial finance, real estate acquisitions and banking law. Johnsons skills include regulatory experience with the U.S. Departments of Labor and Justice, company filings, joint venture agreements and complex transactions for private entities. Johnson received his J.D. from the University of Colorado School of Law and his B.A.in political science from Brigham Young University.

Salt Lake CityInMoment, the leader in customer experience (CX) intelligence, announced that Robert Youngjohns, a software luminary and former EVP, general manager, Hewlett Packard Enterprise (HPE) Software, has been appointed to the companys Board of Directors. For more than 30 years, Youngjohns has played pivotal roles across many of the pioneering technologies and organizations that are the foundation of todays high-tech landscape. Most recently, he led HPEs multi-billion dollar software portfolio, which spanned from Big Data and analytics to security and information management. In this role, he established one of the foremost software portfolios that capitalized on the intersection of structured and unstructured information enabling organizations of all sizes to better manage risk and tap into real business value. Prior to leaving HPE, he facilitated its Software Business Segments nearly $9 billion merger with Micro Focus, creating one of the largest software companies in the world. Yesterday, HPEs majority ownership of the business was spun off into a new entity called Seattle SpinCo. In addition to HPE, Youngjohns was president of Microsoft North America, and served as president and chief executive officer at publicly-traded Callidus Software. There, he initiated the transition of the companys traditional on-premises enterprise software model to a SaaS environment. His experience also includes tenures at Sun Microsystems and IBM, where he held a variety of regional and global leadership positions. Youngjohns currently serves as operating partner at HgCapital, a UK-based private equity firm, and senior advisor with global management consulting firm McKinsey & Co. He also serves as a board member for Blueprint, SiteCore and Densify. Youngjohns has a masters degree with honors in physics and philosophy from Oxford University in the United Kingdom.

OgdenCorporate Alliance of Northern Utah is excited to announce that ReAnne Reimschussel has been named the new Membership Director. She will be meeting with companies of all sizes in Northern Utah to help them reach their goals and connect with the right companies. She attended Weber State University with a focus on Psychology and Business Administration. Previous to Corporate Alliance she was the Executive Corporate Trainer and the Executive Mentoring Director at 3KeyElements. Corporate Alliance is about leading yourself and growing your network. Our training and connecting events are designed to inspire and educate while connecting you with some of the most influential companies in our communities. We help our members create their own powerful networks. People who know them, people who like them and people who trust them.

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Nevada earns D on nonprofit’s new health-care report card – Las Vegas Review-Journal

Posted: August 25, 2017 at 6:43 am

A new nonprofit created by heavy hitters from Nevadas business and medical communities gave the state a D grade on its first report card on the states health care system.

The report card was released Wednesday by the Nevada Medical Center and is intended to focus attention on improving access to quality health care in the state.

Larry Matheis, the NMCs CEO, said the report card will help state leaders focus on the gaps that must be filled to improve Nevadas medical standing. Currently, he said, the states medical system resembles a series of isolated communities due to the lack of collaboration among medical professionals and the dearth of thought given to enhancing our communitys reputation.

The report cards grades, based on analysis of data supplied by the Centers for Disease Control and Prevention and other government agencies, show how Nevada fares in the categories of health care access, chronic disease, nutrition and activity, mental health and substance abuse. The grades werent all bad, with the state receiving a passing C grade on chronic disease and a better-than-average B on nutrition and activity.

The report is online at http:// nvmedicalcenter.org/nevada- healthcare-statistics/.

A guide and resource

Matheis, former executive director of the Nevada State Medical Association, said the report is intended to guide policymakers and recommend new approaches.

We are creating a Nevada Health Commission to use the report as a basis for recommending health policy priorities to the private and public sectors, said Matheis, We also are working with the UNLV School of Medicine to explore the potential for integrative medicine.

Integrative medicine is an approach to care that puts the patient at the center and addresses the full range of physical, emotional, mental, social, spiritual and environmental influences that affect a persons health.

The report card, unveiled Wednesday evening at Delta Point, a community health center near downtown Las Vegas, is among the NMCs first major public initiatives. The organization was founded in 2013 by Eric Hilton, who died in 2016 after 49 years directing the Hilton hotel chain established by his father, Conrad Hilton.

Earlier this month, NMC partnered with the Las Vegas-Clark County Library District to organize play camps at two area libraries, aimed at demonstrating the impact of purposeful play on physical and mental health to young children, Matheis said. It also is developing a similar demonstration program with the Clark County School District to be rolled out at elementary schools in the fall, he said.

Though NMC boosts some high-profile talent board members include New York-New York CEO Cynthia Kiser Murphey and Dr. Florence Jameson, founder of the nonprofit Volunteers in Medicine of Southern Nevada the organization had largely stayed out of the public spotlight before the release of the report card.

The rankings, based on statistics from the 50 states and the District of Columbia, gave the state an F for access to health care through primary care doctors and insurance availability.

Only Mississippi had a worse rate of primary care providers, 53 per 100,000 people, compared with Nevadas 56. The nations capitol, with 116 providers per 100,000 people, fared best.

No quick fix for doctor shortage

Given that Nevadas explosive growth the population nearly doubled from 1.5 million in 1995 to nearly 3 million in 2016 is expected to continue, the NMC set a modest target for access improvement: only one more provider per 100,000 by 2020. Even the creation of the new UNLV School of Medicine its 60 graduates wont be entering residencies for graduate medical education for four years cant do much to help offset retirements by doctors in the near future.

The report cards chronic disease section tracks cases and deaths rates for cancer, diabetes, heart disease and stroke, respiration and kidney disease.

Nevada ranked 21st nationally in the age-adjusted death rate from all forms of cancer, with 157 deaths per 100,000 people per year. Kentucky, at 196 deaths, and Utah, at 125 deaths per year, represented the worst and best states, respectively. The NMC set an improvement target of 155 deaths per 100,000 people for Nevada by 2020. The national average is 159.

Although Nevada received an overall grade of C on issues pertaining to mental health, it received a D on the rate of suicides, with 18 per 100,000 people. Wyoming, at 28 suicides, had the nations highest rate, while the District of Columbias was the lowest at five. The national average is 13. NMC set an improvement target of 17 by 2020.

On substance abuse, Nevada earned an overall C, ranking 26th in the nation on excessive drinking, 21st in smoking, 14th in impaired driving accidents and 39 in fatal drug overdoses.

Nevada did its best on nutrition and activity, largely because of exercise opportunities and physically active adults. The NMC noted, however, that Nevada ranks at or below average in food insecurity (D) and food environment (C), meaning Nevada has room for improvement in making sure people have enough good and the right foods.

The NMCs report card is similar to rating systems used by other organizations to measure Nevadas health care delivery system, including recent reports that found the state lacking on hospital safety and the overall health of its senior citizens.

Contact Paul Harasim at pharasim@reviewjournal.com or 702 387-5273. Follow @paulharasim on Twitter.

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The Drive for Perfect Children Gets a Little Scary – Bloomberg

Posted: August 25, 2017 at 6:42 am

Theres a lot of innovation going on in China these days, but perhaps not all of it is good. Chinese fertility centers are going well beyond American practices, using genetic diagnosis to influence how children conceived through in vitro fertilization will turn out. On one hand, the potential for improving human health is enormous. On the other hand, I am uneasy at the prospect of the power this gives parents. I dont trust people to take so much control over the future of human nature.

Sometimes you hear it argued that the complex nature of genes will prevent major feats of genetic engineering. That may be selling short future advances in Big Data and biomedicine, but even minor changes in genetic diagnosis and selection could have significant effects. Maybe you cant choose to have a child who will be happy, but you might be able to lower the chance of your kid having depression or social anxiety by some small amount. Over the course of generations, that will exert great influence over the nature of the human experience.

QuickTake Gene Editing

One risk, of course, is that parents will opt for some apparently desirable qualities in their children, and then the experiment will backfire, due to unforeseen genetic connections. Maybe well get happier kids, but they will be less creative, or less driven, or they might care less about others. Those are valid concerns, especially in these early days of genetic engineering. But I have a deeper worry, namely that things can go badly even when parents get exactly what they want.

If you could directly alter your kids genetic profile, what would you want? Its hard to know how the social debate would turn out after years of back and forth, but I was dismayed to read one recent research paper by psychologists Rachel M. Latham and Sophie von Stumm. The descriptive title of that work, based on survey evidence, is Mothers want extraversion over conscientiousness or intelligence for their children. Upon reflection, maybe that isnt so surprising, because parents presumably want children who are fun to spend time with.

Would a more extroverted human race be desirable, all things considered? I genuinely dont know, but at the very least I am concerned. The current mix of human personalities and institutions is a delicate balance which, for all of its flaws, has allowed society to survive and progress. Im not looking to make a big roll of the dice on this one.

Its also not difficult to imagine parents wanting children who are relatively well-behaved. The same research paper found that mothers, after extroversion, preferred the trait of agreeableness in their children, again over both intelligence and conscientiousness.

I was struck by a recent Chinese report that some parents are asking for children who are able to drink socially, for business purposes, and thus trying to avoid some genes that make it difficult to process alcohol. Caveat emptor.

Another risk is that parents may be too risk-averse. Especially if a family has only one or two kids, there may be a strong tendency to try to play it safe in terms of personality traits and cognitive abilities. Yet a greater diversity of human types may serve the greater good and perhaps offer intrinsic value too, by making the world an aesthetically richer and more diverse place. Unfortunately, its not hard to imagine a world where many parents opt against prospective children labeled, if only statistically, as too nerdy, too temperamental or too hard-working.

Parents choices, and their eventual public unveiling, may have harmful effects on social norms. What if it becomes known that a high percentage of parents opted for children with paler skin or straighter hair or a greater chance of being heterosexual? That knowledge could boost stigmas and social divisions, even with stringent anti-discrimination legislation. The parental choices could end up being seen as, in essence, the final court of public opinion.

We might expect that the regulators will say no to the most dangerous applications of genetic engineering, but can we be so sure? The techniques will be available in many different countries, and over time the more lax standards will have greater influence, if only through genetic engineering tourism. Parents are also a potent voting bloc, and if they really desire such choices, they may end up getting their way.

In China, these techniques are already about one-third as cheap as in the U.S., interest in them is growing rapidly, and there is talk of having them covered by national health insurance programs.

There is plenty of justified worry about greater discrimination these days, but were hardly talking about the biggest threats.

This column does not necessarily reflect the opinion of the editorial board or Bloomberg LP and its owners.

To contact the author of this story: Tyler Cowen at tcowen2@bloomberg.net

To contact the editor responsible for this story: Stacey Shick at sshick@bloomberg.net

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For Immune System Stem Cell Studies, Mice Aren’t Enough – Science 2.0

Posted: August 25, 2017 at 6:42 am

If mouse studies were transferable to humans, we'd have cured every disease thousands of times. That is the big reason why you shouldn't accept scaremongering about the chemical of the week in the New York Times, or claims about Miracle Vegetables in the Washington Post.

Stem cell therapy is all the rage, with suspect companies sprouting up like supplement stores, claiming to be a benefit for this and that. Often all they have are mouse studies and FDA disclaimers on their side. That's not to say mouse studies are not valuable, they eliminate a lot of bad products, and in some instances mouse models are good analogues of humans, like in HIV infection, but a new paper reveals what chemists have long known: When it comes to the immune system rats are not little people, even "humanized" mice whichhave been engineered to have a human, rather than a murine, immune system.

These animals have been used for decades to study things like the immune response to the transplantation of pancreatic islet cells for diabetes and skin grafts for burn victims. But unlike what would occur in a human patient, the humanized mice are unable to robustly reject the transplantation of genetically mismatched human stem cells. As a result, they can't be used to study the immunosuppressive drugs that patients will likely require after transplant. The researchers conclude that the humanized mouse model is not suitable for studying the human immune response to transplanted stem cells or cells derived from them.

"In an ideal situation, these humanized mice would reject foreign stem cells just as a human patient would," said Joseph Wu, MD, PhD, director of Stanford University School of Medicine's Cardiovascular Institute and professor of cardiovascular medicine and of radiology. "We could then test a variety of immunosuppressive drugs to learn which might work best in patients, or to screen for new drugs that could inhibit this rejection. We can't do that with these animals."

The researchers write in Cell Reports that they were studying pluripotent stem cells, which can become any tissue in the body. They tested the animals' immune response to human embryonic stem cells, which are naturally pluripotent, and to induced pluripotent stem cells. Although iPS cells can be made from a patient's own tissues, future clinical applications will likely rely on pre-screened, FDA-approved banks of stem cell-derived products developed for specific clinical situations, such as heart muscle cells to repair tissue damaged by a heart attack, or endothelial cells to stimulate new blood vessel growth. Unlike patient-specific iPS cells, these cells would be reliable and immediately available for clinical use. But because they won't genetically match each patient, it's likely that they would be rejected without giving the recipients immunosuppressive drugs.

The authors found that two varieties of humanized mice were unable to completely reject unrelated human embryonic stem cells or iPS cells, despite the fact that some human immune cells homed to and were active in the transplanted stem cell grafts. In some cases, the cells not only thrived, but grew rapidly to form cancers called teratomas. In contrast, mice with unaltered immune systems quickly dispatched both forms of human pluripotent stem cells.

The researchers obtained similar results when they transplanted endothelial cells derived from the pluripotent stem cells.

A new mouse model

To understand more about what was happening, they created a new mouse model similar to the humanized mice. Instead of reconstituting the animals' nonexistent immune systems with human cells, however, they used immune and bone marrow cells from a different strain of mice. They then performed the same set of experiments again.

Unlike the humanized mice, these new mice robustly rejected human pluripotent stem cells as well as mouse stem cells from a genetically mismatched strain of mice. In other words, their newly acquired immune systems appeared to be in much better working order.

Although more research needs to be done to identify the cause of the discrepancy between the two types of animals, the researchers speculate it may have something to do with the complexity of the immune system and the need to further optimize the humanized mouse model to perhaps include other types of cells or signaling molecules. In the meantime, they are warning other researchers of potential pitfalls in using this model to screen for immunosuppressive drugs that could be effective after human stem cell transplants.

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New treatment for deadly blood cancers expected to be approved soon – STLtoday.com

Posted: August 25, 2017 at 6:42 am

Cancer doctors in St. Louis are ready to use a new therapy using a patients own blood to fight their disease.

The therapy, called CAR-T, for chimeric antigen receptor T-cell, involves removing immune cells from the blood, reprogramming them genetically to find and destroy cancer cells and then returning the immune cells to the patient. So far, the therapy has been tested on patients with hard-to-treat advanced blood cancers such as leukemia, lymphoma and myeloma that kill more than 58,000 Americans a year.

In one small study sponsored by Novartis Pharmaceuticals, 52 of 63 pediatric and young adult patients with relapsed acute lymphoblastic leukemia went into remission after undergoing CAR-T therapy. The 11 other patients died, seven from the cancer and four from side effects of the treatment.

Acute lymphoblastic leukemia, the most common childhood cancer, can be effectively treated with chemotherapy, but survival rates drop below 30 percent if the patient relapses. Candidates for CAR-T therapy include an estimated 600 children each year who relapse or do not respond to traditional chemotherapy.

At least 16 of the 20 people who have received CAR-T therapy for leukemia or lymphoma through clinical trials at Washington Universitys Siteman Cancer Center have seen their cancers disappear after treatment.

Ive never seen anything in cancer history with that kind of response, said Dr. Armin Ghobadi, an assistant professor in oncology at Washington University. These are the basically bad, incurable, deadly, unstoppable cancers and patients usually die quickly when we dont give them this treatment.

If approved as expected by the Food and Drug Administration, CAR-T therapy could be available locally within a year. Currently no patients at St. Louis Childrens Hospital qualify for the therapy, but patients are expected to come from neighboring states, said Dr. Robert Hayashi, director of hematology/oncology at the hospital.

This advancement is significant and has already demonstrated that it can be an effective form of therapy, Hayashi said. The ability of being able to show a clear success opens the door in terms of what other cancers can benefit from this exact same strategy.

So far the therapy has shown the most effectiveness in cancers of the blood. Another small trial in China involved 33 out of 35 patients experiencing remission from relapsing multiple myeloma, a plasma cancer, after receiving CAR-T therapy.

For decades, scientists have tried to corral the bodys immune system to fight cancer the way it attacks harmful bacteria or viruses. The immune system has a harder time recognizing cancer cells, allowing them to grow. Re-engineering immune cells to fight cancer cells is like turning on the cars headlights at night, Ghobadi said.

A main challenge with CAR-T therapy is the length of time it can take to reprogram the patients blood cells up to three weeks. Researchers are studying ways to reduce the time frame, including engineering universal CAR-T cells derived from donor blood or umbilical cord blood.

CAR-T therapy is expected to cost up to $500,000 for a one-time treatment. Scientists at Washington University are working to engineer the cells in-house, which could lower the price.

The side effects of the treatment can be severe as the immune system is amplified to fight cancer. A complication called cytokine release syndrome can cause life-threatening reactions including brain swelling. In early studies, one-third to one-half of patients treated with CAR-T therapy developed the syndrome. Because patients will need to be closely monitored, drug companies will limit the treatments availability to a few dozen cancer centers nationwide, including Siteman.

Marie Miceli, 64, was one of the first to be treated with CAR-T cell therapy in a trial at Siteman after several rounds of chemotherapy and a stem cell replacement failed to knock out non-Hodgkin lymphoma.

A year later, Miceli is in remission and just celebrated the birth of her fourth grandchild. Miceli, a real estate agent and branch manager at Berkshire Hathaway in St. Louis, said she was blessed to receive the experimental treatment.

You have to trust those doctors and have faith, she said.

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New treatment for deadly blood cancers expected to be approved soon - STLtoday.com

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