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Stem cell therapy for heart failure gets a gold-standard trial – Salon

Posted: August 12, 2017 at 10:44 pm

In the days after a heart attack, surviving patients and their loved ones can breathe a sigh of relief that the immediate danger is over but the scar tissue that forms during the long healing process can inflict lasting damage. Too often it restricts the hearts ability to fill properly between beats, disrupting rhythm and ultimately leading to heart failure. Yet a new possible treatment may help to revitalize an injured ticker.

A cadre of scientists and companies is now trying to prevent or reverse cardiac damage by infusing a cocktail of stem cells into weakened hearts. One company, Melbourne, Australiabased Mesoblast, is already in late-stage clinical trials, treating hundreds of chronic heart failure patients with stem cell precursors drawn from healthy donors hip bones. A randomized trial that includes a placebo group is scheduled to complete enrollment next year.

Mesoblasts earlier-stage trials, published in 2015 inCirculation Research, found that patients who received injections of its cell mixture had no further problems related to heart failure.

Promising results from the new trial would be a major step forward for a field that has long been criticized for studies that are poorly designed, incomplete or lack control-group comparisons, as well as for the peddling of unproved therapies in many clinics worldwide.

Another company, Belgium-based TiGenix, hopes to attack scar tissue before it forms by treating patients with a mixture of heart stem cells within seven days of a heart attack. This approach has just completed phase II trials, but no findings have yet been published.

There are still many unanswered questions about how stem cells typically derived from bones could help heal the heart. Leading theories suggest they may help fight inflammation, revitalize existing heart cells, or drive those cells to divide or promote new blood-vessel growth, says Richard Lee, leader of the cardiovascular program at the Harvard Stem Cell Institute. Other stem cell scientists, including Joshua Hare, who conducted earlier-stage Mesoblast research and directs the Interdisciplinary Stem Cell Institute at the University of Miami, say the cells may work in multiple ways to heal scar tissue. According to Hare, the stem cells could ultimately be a truly regenerative treatment.

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Stem Cell Therapy Selectively Targets and Kills Cancerous Tissue – Anti Aging News

Posted: August 12, 2017 at 10:44 pm

Researchers have created a method to kill cancerous tissue without causing the harmful side effects of chemotherapy.

Medical researchers at the University of California, Irvine have created a stem cell-based method to zero in on cancerous tissue. This method kills the cancerous tissue without causing the nasty side effects of chemotherapy. Such side effects are avoided by treating the disease in a more localized manner. The advancement was spearheaded by associate professor of pharmaceutical sciences Weian Zhao. The details of the stem cell therapy were recently published in Science Translational Medicine.

About the new Stem Cell Therapy

Zhao's team programmed stem cells derived from human bone marrow to pinpoint the specific properties of cancerous tissue. They implemented a portion of code to these engineered cells to identify stiff cancerous tissue, lock onto it and implement therapeutics. The researchers safely used this new stem cell therapy in mice to kill metastatic breast cancer that had moved to the lungs. They transplanted these engineered stem cells in order for the teamto pinpoint and settle in the site of the tumor.

Once the stem cells reached the tumor, they released enzymes referred to as cytosine deaminase. The mice were then provided with an inactive chemotherapy known as prodrug 5-flurocytosine. The tumor enzymes stimulated the chemotherapy into action. Zhao stated his team zeroed in on metastatic cancer that occurs when the disease moves to additional parts of the body. Metastatic tumors are especially dangerous. They are responsible for90 percent of all cancer deaths.

Why the new Stem Cell Therapy is Important

Zhao is adamant his stem cell therapy represents an important newparadigm in the context of cancer therapy. Indeed, Zhao has blazed a trail in a new direction that others will likely follow in the years to come. It is possible his new stem cell therapy serves as an alternative and more effective means of treating cancer. This stem cell therapy will serve as an alternative to numerous forms of chemotherapy that typically have nasty side effects. Chemotherapy certainly kills plenty of growing cancer cells yet it can also harm healthy cells. The new type of treatment keys in on metastatic tissue that allows for the avoidance of the undesirable side effects produced by chemotherapy.

Though the published piece describing this stem cell therapy is centered on breast cancer metastases within thelungs, the method will soon be applicable to additional metastases. This is due to the fact that numerous solid tumors are stiffer than regular tissue. The new system does not force scientists to invest time and effort to pinpoint and create a brand new protein or genetic marker for each kind of cancer.

The Next Step

At this point in time, Zhao's team has performed pre-clinical animal studies to show the treatment is effective and safe. They plan to segue to human studies in the coming months and years. Zhao's team is currently expanding to additional types of cells such as cancer tissue-sensing and engineered immune system CAR-T (T cells) to treat metastasizing colon and breast cancers. Their goal is totransform this technology for the treatment of additional diseases ranging from diabetes to fibrosis and beyond.

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Odessa physician offering stem cell therapy – Odessa American: News – Odessa American

Posted: August 12, 2017 at 10:44 pm

An Odessa physician who specializes in pain management has begun offering stem cell therapy for inflammation from a variety of arthritis.

Dr. Mandeep Othee of ProCare Interventional Pain Medicine, said stem cell therapy has been around since as early as 1938. It has recently been used to stem inflammation, wound care and post-surgical use to help in healing.

The purpose for me is going to be for inflammation for knee arthritis, shoulder arthritis any sort of arthritic process in the neck, the back; any part of the body, Othee said.

Othee said hes always interested in cutting-edge treatments. As associate medical director of In-Patient Rehabilitation at Medical Center Hospital, Othee oversees care for patients with a variety of orthopedic needs, ranging from stroke patients to those recovering from joint replacement surgery, the hospital website said.

He also specializes in diagnosing and treating neck and low-back pain.

The source of the amniotic stem cells is healthy women who have had C-sections who donate their amniotic fluid to a tissue bank. Othee said it is fully regulated by the U.S. Food and Drug Administration and the cells are purified and frozen to preserve them.

The cells provide cushioning, support and lubrication to a developing fetus in the womb.

Its a similar process in the body, so for example, if we take that same stem cell and inject it into the patients knee, or shoulder, or back, or neck it provides the same cushioning, support, lubrication and inflammation reduction that it does in the developing fetus, Othee said.

He added that there are 226 growth factors in the fluid itself, which includes proteins, lipids electrolytes and the magic element of hyaluronic acid.

Thats the typical injection a patient receives in an orthopedic surgeons office. It basically heals the area, provides collagen synthesis and helps with the re-growth of that lost cartilage , Othee said.

Cartilage wears down over time in the joints and injecting the stem cells greatly increases the patients own healing response. Othee said it works 100,000 times better than Platelet Rich Plasma, which is taking a patients own platelets, spinning it down, putting it into a concentrated format and injecting into the patients knee, shoulder, neck or back, Othee said.

Typically, Othee said hes read studies have shown 30, 90 and 100-day responses that are better than steroid shots or hyaluronic acid injections.

It can help patients avoid or delay joint replacement surgeries.

The product he chose is OrthoFlo made by MiMedx.

I chose them because theyre the biggest and the best, Othee said. Their company specializes in different products. One is OrthoFlo. It contains pro-growth factors (and) no tissue fragments or dead cells. It is highly purified human amniotic fluid.

He noted that thousands of injections have been administered over the last five to 15 years and no reactions, side effects or infections have been reported that hes read about.

Currently, no insurance companies pay for the stem cell therapy, but athletes have been getting these for years in other countries, such as Germany and England, and larger cities such as Houston and Dallas. The cost is $2,200 per injection from Othee.

The patient may be sore for a day or two after the stem cell injection and they are able to walk out of the office without a problem. For any sort of knee injections, Othee said a patient may want to wait a week to start running or doing other activities.

Othee said he usually asks patients to stop taking anti-inflammatory medicine for at least seven days before and after the treatment.

He added that there is no age limit on people who could receive stem cell therapy.

Othee said patients may have tried steroid shots, hyaluronic acid, or platelet rich plasma before stem cell therapy. However, they could skip right to stem cell therapy, he added.

Othee said he has spoken to other doctors with patients who have gone straight to stem cell therapy and it works.

Orthopedic surgeon Dr. Vijay Borra doesnt do stem cell injections. He said he thinks research into stem cells just as an injection for osteoarthritis is still in its infancy.

I think a lot of research now is going into using stem cells to generate chondrocytes, which are cartilage to see if we can plug in focal cartilage deficits. Thats where all the research is now. As far as just injecting stem cells into the joint, were still at the very early stages and theres still very little data as to whether it actually works or not, Borra said.

Borra added that there is a lot of good data using that to generate cartilage.

Theres some data there can be used to plug defects. Its an option for people who have done everything like a steroid or hyaluronic gel injections. Theyve done all that and they dont want a knee replacement, or they have too many medical issues and theyre not a candidate. Then it is an option. If theres nothing else, then stem cell is an option, Borra said.

He added that stem cell therapy is not covered by most insurance plans and the out-of-pocket pay is very high.

Its really like an end-stage resort for someone who doesnt want surgery. Theres really no down side. Its not going to do any damage, so you can always try to see if it helps, Borra said.

When patients come to see him, Borra said he first gives them an x-ray to see what the problem is. Most of the time, its osteoarthritis.

By the time they come to Borra, he said the patient has tried anti-inflammatories, weight loss and therapy.

Theyve already done all that, so I start off with a steroid injection. If it works five, six months some people choose to do two or three a year. If it doesnt work, the next option is gel injections, hyaluronic acid, which is like artificial joint fluid, Borra said.

He said Othee also offers nerve blocks.

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Mutation-directed CAR T cell therapy feasible in recurrent glioblastoma – medwireNews

Posted: August 12, 2017 at 10:44 pm

medwireNews: Treatment with autologous chimeric antigen receptor (CAR) T cells directed against the epidermal growth factor receptor variant III (EGFRvIII) mutation is feasible and well tolerated in patients with recurrent glioblastoma, indicates a first-in-human study.

But barriers to the clinical efficacy of the therapy exist, says the research team, including the inhibitory tumor microenvironment, which becomes even more immunosuppressive after CAR T cells.

Lead author Marcela Maus (Massachusetts General Hospital, Boston, USA) and colleagues chose the EGFRvIII mutation as it is a tumor-specific, oncogenic, and immunogenic epitope expressed in around 30% of newly diagnosed cases of glioblastoma.

In this phase I study, reported in Science Translational Medicine, 10 patients with EGFRvIII-expressing glioblastoma that had progressed after at least one prior line of therapy were given a single infusion of an autologous EGFRvIII-directed CAR T product within a week of progression.

There were no dose-limiting toxicities, and no evidence of off-target EGFR-directed effects such as rash, diarrhea, or pulmonary symptoms or systemic cytokine release syndrome.

Neurologic events were observed in three patients and included a seizure at day 9 in one patient and neurologic decline in two patients, at day 15 in one case and postoperatively in the other. Although such events are common in glioblastoma patients due to the nature of the disease, Maus et al say that they could also result from CAR T-induced immune responses in the confined intracranial space.

They were unable to formally assess efficacy as the majority (n=7) of study participants underwent surgery following infusion of the CAR T cells. But one patient was alive and required no further treatment for 18months or more after the infusion. A further two patients were also alive at the time of analysis, but they showed signs of disease progression by imaging criteria.

The surgical intervention allowed the researchers to evaluate not only tissue-specific trafficking of CAR T cells and on-target effects, but also the tumor microenvironment in situ.

Analysis of tumor samples showed the presence of EGFRvIIICAR T cells in the brain, with higher levels in the four patients who had surgery within 14days of the infusion than in the three who underwent surgery at later timepoints.

And comparison of post-infusion samples with matched samples obtained before the infusion revealed a significant decline in the expression levels of EGFRvIII in five of the seven participants with available samples. Such a decrease in antigen expression in the remaining tumor bed and tissue is indicative of on-target effects, say Maus and colleagues.

But they also found that the expression of several immunosuppressive molecules, including indoleamine 2,3-dioxygenase 1, was markedly increased in post- versus pre-infusion samples, and noted elevations in the relative proportion of immunosuppressive FoxP3+ regulatory T cells after infusion.

These findings suggest that CART-EGFRvIII activation induced a compensatory multifactorial immunosuppressive response in situ, say the investigators, adding that it could potentially be overcome with existing drugs that target immunosuppressive molecules.

Study author Donald ORourke, from the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, USA, told the press: This is an early stage trial, but we are encouraged by the fact that the cells got into the brain, proliferated, and reduced the level of antigen with very little toxicity to the patients. We can build on this as a therapeutic option for these patients. It gives us clues on what to do next.

By Shreeya Nanda

medwireNews is an independent medical news service provided by Springer Healthcare. 2017 Springer Healthcare part of the Springer Nature group

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Md. Medicaid should cover trans-specific care – Baltimore Sun

Posted: August 12, 2017 at 10:43 pm

The 45th presidents recent tweets banning transgender people from serving in the military because of their potential medical costs underscores the difficulties the transgender community faces in accessing quality health care. They often face stigma and discrimination by health professionals, and even if they have insurance, they may not have coverage for gender affirming procedures like hormone replacement therapy (HRT) or sex affirming surgery (SAS).

On some insurance plans, including Maryland Medicaid, prior authorization is required for someone who is transgender to receive HRT or SAS. Prior authorization is typically used to confirm that extraordinary requests are medically necessary, like transplants or cosmetic surgery. The transgender community shouldnt have to ask permission and submit claims before receiving life-affirming care.

According to the World Professional Association for Transgender Health, the standards of care for the transgender community include psychotherapy, HRT, changes in gender expression and SAS. Individuals may choose to use all, some or none of these in their health management of gender expression. These are particular therapeutic needs for this population. Although there may be some overlap with cisgender people (those whose personal gender identity corresponds with their birth sex) like psychotherapy, prostate exams and mammograms it is unethical to require preauthorization for other care that is specific to a community because it is different from the majority.

Currently the Affordable Care Act does not exclude the transgender population from some medically necessary care based on gender identity. This means a man can get insurance coverage for a pap smear, but not HRT. The language in the act is ciscentric, and wasnt specific enough to make insurance companies provide coverage for HRT and SAS. Even the quality metrics Maryland uses for its insurance plans do not include sexual orientation and gender identity information. So people in the community who are shopping for private insurance have no way of knowing if their care is covered in benefit plans. Transgender people have not been given a seat at the table in health care decision-making.

Fortunately, as a state, we can shift insurance coverage to include transgender specific care starting with Medicaid. Coverage under Medicaid would give the most vulnerable population access to quality care: 26 percent of the transgender population lives under the federal poverty line ($12,060 for individuals per year). Poverty in this community leaves people susceptible to violence, drug abuse and depression. Providing this population with access to life affirming care through Medicaid would set an example for private insurance plans to start allowing trans-specific health coverage.

This small step toward transgender insurance parity under Medicaid offers huge opportunities for the community in the health care field and beyond. There would be more understanding of hormone therapy and its side effects, long-term effects and dosing. Visibility in the health care arena can transition bias and discrimination among providers to compassion and understanding. Shifts in provider perception will result in the quality care needed to address the mental illnesses, housing instability and drug abuse that runs in the community. The increased demand to address those needs could transform into a specialized field of transgender health. The possibilities are endless.

California already mandates insurance coverage for life-affirming care in the transgender community. No significant changes were made to their budget for the accommodation, and insurance surcharges on private insurances were actually dropped because there was no significant cost for adding trans-specific care to their benefits.

Every year the transgender community becomes more and more visible; we are doing them a great disservice by ignoring their needs for health care specific to their community. We can take these steps of social progress and apply it on a national level and provide access to quality health care to all Americans.

Chigo Oguh (coguh@umaryland.edu) is a graduate student at the University of Maryland, Baltimore.

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What’s the Cultural Impact of Transgender Characters on TV? – Newsweek

Posted: August 12, 2017 at 10:43 pm

This article originally appeared on The Conversation.

In 2014, Time magazine declared American culture had reached a transgender tipping point, with transgender people achieving unprecedented media visibility.

However, in light of recent policy shifts such as the White Housesrollback of federal guidelines that supported transgender studentsand Trumps July 26Twitter pronouncementthat the U.S. military will no longer allow transgender service members some have questioned whether this visibility has actually meant greater acceptance of trans people.

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The cast of 'Transparent,' the acclaimed Amazon original series. Transparent/Amazon Prime

Studies have shown thatentertainment has the powerto shape attitudes on health and social issues, fromorgan donationto thedeath penalty. But little research has explored the impact of portrayals of transgender people.

For this reason, we wanted to see how transgender TV characters might influence the attitudes of viewers. Specifically,we testedwhether political ideology plays a role in how audiences respond to these potentially polarizing depictions.

Transgender Media Visibility

Times transgender tipping point from a few years ago was attributed to fictional trans characters in shows like Transparentand Orange Is the New Blackandnews coverageof controversial policy issues, such asdiscrimination lawsuitsabout school bathrooms. In April 2015,nearly 17 million peoplewatched Caitlyn Jenner come out as transgender on 20/20.

It was in this context that the USA Network drama Royal Painsincluded a storyline about a fictional transgender teen named Anna who experiences complications while transitioning from male to female. Although Annas subplot lasted only 11 minutes, it grappled with numerous issues: the medical professions historical treatment of transgender individuals as mentally ill, parental rights regarding adolescent transitions and the risks of hormone replacement therapy.

Actress Laverne Cox, left, and writer Janet Mock embrace each other at the 23rd annual Gay and Lesbian Alliance Against Defamation (GLAAD) Media Awards in New York March 24, 2012. Andrew Kelly/Reuters

We first learned of the upcoming Royal Painsstoryline in early 2015, when the shows writers contacted Hollywood, Health & Society (HH&S), a USC Annenberg-affiliated program that gives entertainment industry professionals accurate and timely information for storylines on health, safety and national security. (Erica is a researcher at HH&S.)

HH&S facilitated conversations between the writers and an expert in the medical treatment of transgender youth. The resulting June 23, 2015 episode, "The Prince of Nucleotides, receiveda 2016 GLAAD Media Award, with transgender activistNicole Mainesmaking her acting debut as Anna.

Media Bubbles

Before we could study the impact of Annas storyline, we wanted to make sure that the audience was mixed in its views on transgender rights in other words, that the show wouldnt simply be preaching to the choir.

Since the 2016 U.S. election,countlessstorieshave explored the media bubbles in which Americans live. This trend toward fragmentation permeates news, social media andentertainment. TV shows with broad audience appeal tend to address hot-button social issues relatively infrequently andsuperficially. Regular viewers of boundary-pushing series, on the other hand, may alreadybe left-leaning.

Research by GLAAD (the Gay & Lesbian Alliance Against Defamation) indicates that transgender characters have appeared primarily on streaming platforms and premium cable channels, while broadcast network showswhich have larger audiencestend to feature transgender characters only in brief storylines, if at all.

This means viewers disinclined to watch a show like Transparent,which features several trans characters, might still encounter such characters in minor storylines in mainstream programs.

Royal Pains(2009-2016) was about as mainstream as TV gets today. The show had no real history of addressing LGBTQ issues, so Annas episode was unlikely to attract a particularly trans-supportive audience. For us, this made it the ideal show to study transgender portrayals and how they might influence viewers across the ideological spectrum.

Do Minor Subplots Make a Difference?

Because HH&S had consulted on the storyline, the members of USA Networks social media team were open to helping us with our study. They posted links to our survey on the shows official Facebook and Twitter accounts following the episode. We supplemented this sample by recruiting Royal Painsviewers from market research panels. Only those who had seen the episode or one of the two prior episodes were eligible. Of the 488 viewers in our study, 391 had seen Annas episode.

Because there were several different shows at the time featuring transgender characters, we asked viewers which of these they had seen. We also measured their exposure to transgender issues in the news, including the unfolding Caitlyn Jenner story.

Finally, we examined several important variables that are known to impact viewers. These includeidentificationwith main characters, a sense of being drawn into the world of the story (what media scholars call transportation) and theemotions evokedby the storyline.

We foundthat Royal Painsviewers who saw Annas story had more supportive attitudes toward transgender people and policies, and we found a cumulative effect of exposure to transgender entertainment narratives. The more portrayals viewers saw, the more supportive their attitudes. Neither exposure to such issues in the news nor Caitlyn Jenners story had any effect on attitudes. In other words, the fictional stories we examined were more influential than events in the news.

Consistent withprevious research, in our data, political conservatism strongly predicted negative attitudes toward transgender people and lower support for policies that benefit transgender people. However, exposure to two or more transgender storylines cut the strength of this link in half. That is, politically conservative viewers who saw multiple shows featuring transgender characters had more positive attitudes toward trans people than those who saw just one.

Political ideology also shaped viewers responses to the Royal Painsnarrative. Those who were politically liberal were more likely to feel hope or identify with Anna, whereas those who were politically conservative were more likely to react with disgust.

Beyond the Bubble

Hollywood is not a panacea for healing our nations deep partisan and ideological divisions. To influence attitudes on a broad scale, entertainment storylines must first reach audiences outside cloistered media bubbles.

However, our research suggests nuanced portrayals of transgender individualsparticularly in mainstream forms of entertainmentcan break down ideological barriers in a way that news stories may not. Cumulative exposure across multiple shows had the greatest impact on attitudes, but even a relatively brief storyline had a powerful effect too. While politically conservative viewers were more likely to react with disgust, such reactions were tempered by seeing trans characters on a variety of shows.

At a recent GLAAD-sponsored panel,trans actress and activist Laverne Cox noted:

Weve got to tell these stories better because lives are on the line. Trans people are being murdered, are being denied health care, access to bathrooms and employment and housing because of all of thesemisconceptions that people have about who we really are.

As the future ofthousands of active duty service membershangs in the balance, its more imperative than ever to understand how the public responds to media representations of transgender people.

Erica L. Rosenthal is a Senior Research Associate, Hollywood, Health & Society, University of Southern California.

Traci Gillig is a PhD Candidate in Communication, University of Southern California, Annenberg School for Communication and Journalism.

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Niwot author pioneers interventions for Autoimmune Disease – Left Hand Valley Courier

Posted: August 12, 2017 at 10:43 pm

Along with the growing stressors of modern life, theres been a corresponding dependence on fatigue fighters such as energy drinks, triple-shot lattes and Mountain Dew. We take supplements to re-charge our metabolic systems, often reaching for quick-fix solutions when what we really need is to rest and recharge. But then, whos got the time?

But without time spent each day in an anabolic state, or what Niwot author and pharmacist Dr. Izabella Wentz calls a state of rest and digest, were basically telling our bodies that were unsafea situation that, over a sustained period, triggers biologic responses that can lead to autoimmune conditions.

At 27, Wentz was diagnosed with Hashimotos disease, also known as hypothyroidism, an autoimmune condition that results in an underactive thyroid gland. Wentz often felt cold, with other symptoms including hair loss, acid reflux, fatigue and depression. Like many autoimmune sufferers, she was told by doctors that her symptoms were just in her head.

One doctor told her she was experiencing the normal signs of aging, she said. That was her wake-up call. From then on Wentz took a more active role in figuring out her own road back to health.

That plan led to remission, and her recovery eventually led to the publication of her latest New York Times bestseller, Hashimotos Protocol: a 90-day plan for reversing thyroid symptoms and getting your life back, which released on March 28, 2017.

The condition runs in Wentzs family, and she attributes her mother as the force behind the book, urging her to write so that my cousins in Poland would start feeling better too, she said.

The thyroid is a small, butterfly-shaped gland that produces hormones such as thyroxine (T4) and triiodothyronine (T3), which stimulate vital processes throughout the body. Not coincidentally, thyroid hormones impact the proper functioning of the bodys heat production, its ability to make use of vitamins, proteins, carbohydrates and fats, along with fertility and growth. In hypothyroidism, the bodys immune system attacks its own cells, and if not caught in its early stages, the gland can become permanently damaged.

Hormone replacement therapy is the first step on the road to recovery, but because Hashimotos is so complex, Wentz recommends several dietary and lifestyle changes as well.

Gluten seems to be a major trigger for producing an autoimmune response. Cardiologist and author, Dr. William Davis, argues in his 2011 book, Wheat Belly: Lose the Wheat, Lose the Weight, that genetically altered Frankenwheat has been imposed on the public by agricultural geneticists and agribusinesses to disastrous results for the collective gut.

But whatever the cause of the populations prevalent wheat sensitivities, Wentzs protocol encourages a 90-day abstinence from flare-up triggers such as wheat, alcohol and caffeine, and recommends that anyone diagnosed with Hashimotos to remain gluten-free indefinitely.

An estimated 20 million Americans suffer from some form of thyroid disease, according to the American Thyroid Association. And though theres a disproportionate number of women hit with thyroid conditions, theres no known reason why. But Wentz offers some theories, which include exposure to toxins in personal care products, along with pregnancy, genetics and culture.

Women often put themselves last, she said. Theres a stigma attached to women who demand attention or have too many needstheyre considered high maintenance.

In addition, [Women] jump from one activity to the next, from school to work, to childrens sports, to homework to dinner. Were rushed in the mornings, we eat in the carour time is overly scheduled.

For every one man, she said, five to eight women are diagnosed with a thyroid condition.

Hashimotos triggers also include nutrient depletions, food sensitivities and intestinal permeability (also known as leaky gut), among others. So it makes sense that treatment includes changes in eating and other lifestyle behaviors.

Taking probiotics helps to balance gut flora, and the removal of triggering foods from the diet can make huge changes in an autoimmune sufferers sense of well-being. But the biggest impact, for Wentz, happened when she started taking a thiamine supplementsimple vitamin B1.

Youll know in five days if its going to help, she said. It helped resolve her fatigue issues. Another easy solution with a huge payoff came over-the-counter as well: digestive enzymes. Other recommendations include gut-healing nutrients, such as Omega-3s, zinc, L-glutamine and bone broth.

Stress causes the adrenal glands to pump out extra hormones, shifting the body from a relaxing, digesting and healing state, to a fight-or-flight response state. To promote the rest-and-digest state, Wentz suggests introducing more self-care activities. Sipping hot lemon water in the mornings for its liver-supporting properties while enjoying a warm water foot soak will give the metabolism a boost.

You can add lavender or other essential oils to the water, [and] set your intentions for the day, she said.

She also recommends spending an hour every day reading inspirational or spiritual books, Whatever you find uplifting, she said. Journaling can also be helpful. You can make a list of your health goals and journal about it. Then check in with yourself.

She also suggests celebrating small successes. Maybe your hair has stopped falling out (though maybe it hasnt grown back yet), but stillits progress, she said. Listen to your body, she continued. If youre tired, take a nap. If youre taking a lot of Maalox, eat less acid-forming foods, such as fresh vegetables, and avoid sugar, caffeine and alcohol. You can do anything for 90 days. The results may just be worth it.

Wentz has a Facebook community where people with Hashimotos write in with questions ranging from how to combat a vitamin B12 deficiency (she recommends sublingual tablets), to whether or not sufferers should stop dyeing their hair (yes). Visit her at Facebook.com/thyroidlifestyle. Hashimotos Protocol, and Wentzs first book, Hashimotos Thyroiditis, are available at most major book retailers.

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Transitioning: Controversy, corrections and new-found peace, Misty Lane is finally finding happiness with herself – Douglas Budget

Posted: August 12, 2017 at 10:43 pm

The camper was never meant to be anyones home, but the 120-acre spread it sits on is the closest thing to a home the tenant has ever known. More importantly, it marks the place where one way of life ends, andanother begins. In most cases, a name doesnt matter.

For this story, its critical.

Start with Mark.

For the first 20 years of his life, he was a tattooed, muscled roughneck who worked oil rigs, collected muscle cars and raced mud bog trucks; a real self-described Wyoming redneck. When Mark was 21, he legally changed his name to Misty. And for the first time in his life, Mark felt he was who he is supposed to be a woman. Mark, now Misty, puts on eye shadow, wears frilly shirts and dons tennis shoes with pink laces when she climbs under the car to change the oil.

Misty is very much a mans man. In this regard, her gender identity is still at odds with her sex in that shes still very much a guy when it comes to her interests, including her preference for dating women. Ironically, the more comfortable she feels in her female body with breast implants and hormone therapy, the more ostracized she becomes in the community.

Life would be easier if Misty left Wyoming.

But just as her personal interests havent changed, she loves everything shes always loved about living out West. She doesnt expect people to understand, nor does she blame anyone for their reaction, particularly given where they live. Wyoming isnt exactly open-minded when it comes to homosexuals and transgenders. The Code of the West is pretty straightforward when it comes to gender: guys are guys.

Despite all masculine traits to the contrary, she identifies female, which she realizes is hard to explain to someone who was born with the correct body.

I dont think its an issue of want. You have to, she says, biting a corner of her blunt thumbnail. Essentially, you have the base knowledge that somethings not right. Eventually, it eats away at you like a cancer. But its not eating away at your body, its eating away at your soul.

The reverberation in her Pops garage is squint-worthy. A lit Marlboro dangling from one corner of her mouth and mirror Raybans pushed back on the top of her head, Misty smiles through the windshield of her vintage Camero and gives it another rev.

Its an original SS, she screams over the roar, rattling off a list of bits and pieces that apparently make it faster and louder. Under the white-striped ebony hood, the engine screams.

She jumps out to show off some of the original components underneath the hood, struggling with one hand to release the latch. The other hand rests idly at her side like an inflated surgical glove, swollen with a staph infection that wont seem to go away, despite the daily trips to Casper for antibiotics.

She slammed her hand under the hood of her truck last week.

This is where Misty and Mark begin to diverge. Despite the long hair and frosty pink eye shadow, her hands still belong to Mark. Thick-knuckled with half moons of grease under the nails, these are hands used to doing dirty work.

This has always been her passion. Shes a certified mechanic and, as Mark, had worked for years in the trade, even owning her own shop.

Now, as Misty, its much harder to find work. People arent exactly clamoring to hire a former man who now identifies as a female. The trouble is that though her genders changed, her skills havent.

Doors dont exactly open to a man wearing make up and pink shoelaces and introducing herself with a girls name. Usually, the employer says that she doesnt fit their company image or says there are no openings. Sometimes shes just met with abject stares and smirks.

Its funny people will hire ex-cons no problem, Misty says, flicking an ash on the ground after a deep inhale, but forget about hiring a transgender.

Unfortunately for Misty, she falls into both categories. Worse, she bears the label of a registered sex offender given that she went to jail after a lusty night of heavy petting with a 14 year old an encounter that landed her two years in prison and another year of probation. Shes been out for less than 10 months.

Misty is stoic when it comes to defending that charge. She screwed up, plain and simple. The girl lied about her age, Misty says, and she didnt think to check her ID.

Thats completely on me and Ive served my time.

Misty shrugs. Shit happens.

I may have a shitty reputation as a person, she says, squinting as she tightens a bolt, but Im a damned good mechanic.

Smart, too, she adds, not afraid to admit she has an IQ of 142. She loves working on cars and would prefer spending her days in a garage away from people. Cars make sense to her, people dont.

That includes herself.

All her life she felt that something wasnt quite right but it took her years to realize that it was her gender.

Shed always felt more comfortable as a female, beginning with her earliest memory of her sister and cousin dressing her up in their clothing, but how, as a boy, do you admit that out loud? Especially when its clear your parents disapprove. Misty remembers being confused when her father beat the hell out of her after finding Mark wearing a dress, berating his sisters for trying to turn him into some kind of sissy.

Clothing plays a big part in Marks gender identity, both as a haven and a form of torture. She prefers feminine clothing and always has. Mistys worst childhood memories revolve around holidays and being forced to wear suits and ties. She had no idea why it made her miserable.

Her confusion, too, was compounded as a teenager, when she went to see the doctor about a bladder infection, and according to Misty, found out she also had a uterus and was therefore considered innersex, the term for a person born with the sexual or reproductive anatomy of both a female and male. Oddly, innersex births are more common that one might think. According to the Intersex Society of North America, it occurs in nearly one in every 2,000 births.

The fact that she had a uterus didnt exactly make the situation any better.

How do you approach a person with that statement, Misty laughs, bitterly. She didnt have anyone to talk to about this when she was younger, so she just tried to live with it and do her best to fit in.

Trying to do anything outside of the social norm as a teenager is hard enough, she says. It doesnt matter what it is. Its not met well.

This grin-and-bear-it strategy didnt work, however, and after two suicide attempts in her early twenties, she realized she only had one choice: Become a woman or die.

Theres no way to explain how it feels to be born with the wrong body. You either get it or you dont. What Misty can tell you, however, is that the day she buried Mark and became Misty was the moment she realized what it felt like to breathe.

First the name change, then came breast implants, hormone replacement therapy, make up and female clothing.

Its hard to explain, Misty says, but when you start to transform physically, the mental follows. These thoughts and feelings have always been inside her but up until now shes worked hard to hide it. With every step toward transition, she feels a weight being lifted.

Its kinda like being on deadline, Misty pauses. Like theres so much stress and pressure trying to get the work done, but the second that you meet that deadline, you instantly feel a sense of relief.

There are a lot of people who dont get what it means to be transgender, she adds. People think its some kind of fetish, guys who like to put on make up and dresses and pretend to be a girl.

For Misty, it means living in a body where she feels she finally belongs. Its real. The make up and clothing reinforce her sense of femininity. Shes not doing this for attention.

Believe her. Theres nothing fun about being stared at or having obscenities yelled at you or otherwise being treated like some kind of freak, especially here.

Look around you, she shrugs. Lets face it, Wyoming hasnt exactly evolved a lot. If you want to experience the old West, just go outside.

Regardless of geography, Misty chooses to live as a woman with the goal of saving enough money to have gender reassignment surgery, a procedure that involves turning her penis into a vagina. The hefty price tag$22,000 just for the surgery alonekeeps it a faraway dream, but shes determined to make it happen. Shes met the criteria, talked to several doctors and has done the research. Now, its just a matter of when.

Im not going to cave, Misty says, slamming the hood as she reaches into her back pocket for another smoke. Its not in my nature. Id be more afraid of meeting my maker and telling him why I didnt have the courage to do what I needed to do.

Theres an official process involved when it comes to switching genders. In order to officially become a woman, surgically speaking, Misty had to first prove she has lived in a female role for over a year and had to do so many months of hormone therapy replacement treatment. She also had to have a psychological evaluation that validated, that yes, she identified as a female.

That part, logistically speaking, was easy.

The harder part comes now as she leaves Marks world behind in order to become Misty. One doesnt ever get to easily dispose of a body, even if just in name only.

First there are a few demons to exorcise, starting with teenage Mark, a tough guy with a chip on his shoulder.

I wasnt a very nice person back then, Misty says, shrugging.

And those who knew him in high school, like Maria Bromley, would agree. Though Maria hated Mark in high school, shes since fallen in love with Misty, who shes learned to see in an entirely new light.

He was pretty much a total a**hole, Maria says, cuddling now against Mistys shoulder.

Its fair to say I wasnt a very nice person, Misty says with a tight-lipped grin. As Misty, shes still trying to get used to pubic affection and other social niceties like smiling.

You think? Maria jokes. Mark pretty much told you exactly what he thought.

Back then Mark was pumped up with muscles and enjoyed going to school drunk and doing everything he could to mess with teachers.

He was also pretty violent. A lot of this anger stemmed from hating his life and his circumstances.

Its hard to be happy when you feel like every part of your life is a lie, Misty says, staring through the kitchen window. Outside, the finger-like branches of a maple tree bend in the gusty wind as if clenching together in a fist.

Marks also left behind some causalities, including three daughters from two different women from relationships in his late teens. Misty doesnt have too many good things to say about one of the moms, Katie, who cleared out his checking account one day while he was at work and refuses to let her see her girls, despite the fact they have joint custody.

Mistys youngest girl was given up for adoption when Misty was working out of the country on a drilling rig. Misty didnt know the daughter was hers until a year after she returned.

Nonetheless, its a sore spot.

My children mean everything to me, Misty says defiantly, when pressed to remember the last time shes seen or talked to any of them.

Shes vague about their lives. Misty repeats how much she loves them. Marks oldest daughter picked her new name Misty, she quietly recalls.

She has no idea when shell see them again.

This is a common refrain in Mistys life: people who have wronged her or dislike her leaving unseen emotional scars.

Nonetheless, Misty makes it clear that she doesnt put up with anyones crap or abuse.

She tells a story about an elderly woman who lived in a trailer park near her years ago and how this woman would always complain about Mistys truck being too loud. So Misty checked the local noise ordinance and set her engine to two decibels below the max. When she worked on her truck, it sounded like a drag strip. The woman called the police who came out to test the decibel levels, which were always within the legal range. The woman finally sold her trailer and moved, Misty says, smiling.

The lesson is clear: hurt me, and Ill hurt you. Leave me alone, and Ill be cool to you.

Shes still dealing with a lot of anger, Misty confesses. Its going to take some time.

Maria needs a cigarette.

Theyre in my purse, babe, Misty says, twisting in her chair to grab a small glittery bag off the floor near Marias feet.

The door shuts behind Maria and soon a cloud of smoke fills the window behind Mistys head.

They are in her grandfather Gale Lane, or Pops, kitchen, the one home where Mistys always been welcome. For the past decade, Pops has been slowly declining with Alzheimers and at present has little recollection of his earlier life.

Pops and Bonnie, Marks step-grandmother, have been the only people in her life who have half-way understood, or at least accepted Misty, no matter what. For that, she loves them deeply.

Theres a lot of pain in Mistys past, starting with Marks relationship with his dad, which deteriorated even more when he began dressing in his sisters clothes.

Picture a six-foot something mans man, Misty describes her father. The fact that Misty mainly takes after her motherwho left the family when Mark was 9was another sore point for her father. Basically, my dad had a lot of reasons for beating the shit out of me.

That was just the start of Marks problems, which culminated in him getting into lots of trouble at school, and, finally, for reasons Misty refuses to disclose, eventually landed Mark in a juvenile facility at age 13.

After shuffling throughout several facilities throughout the state, he ended up in a group home in Douglas, which left some good memories. The woman who ran the place was kind, Misty says. Life there wasnt too bad.

Eventually, Mark graduated from high school, enrolled in college, then headed to the oil field. Misty got a commercial drivers license and went to mechanic school.

The door opens and Maria is back. She wants to clear the air about Marks violent past. Mark was dealing with a lot of anger because he couldnt be the person he needed to become, she insists.

Maria likens it to being in an abusive relationship. Her voice gets soft as she describes how that life becomes your reality and when youre stuck in the middle of it, you know that anything you do can never be right because youll never be able to please that person. You become somebody youre not.

Thats how Misty felt, she says. She couldnt find any glimmer of happiness in herself, so how on earth could she find happiness anywhere else?

The waitress at the Village Inn does a double take when Misty, in a male voice, orders a double cheeseburger and a Coke with fries. Up until that point, Misty and Maria had been just two more attractive blonde women in a morning when she already seen plenty. Now, the waitress takes a closer look at the woman with the male voice.

Sometimes, Misty softens her voice to blend in, but only when she wants to.

A couple of middle-aged cowboys at a nearby table swivel in their seats to eyeball Misty with prolonged stares. Blondes always turn a few heads, but theres something about her face that doesnt quite fit. Much like a face can either look 20 or 50, gender too is revealed in the bones. The men smirk.

This is typical of the range of reactions Misty gets in public: stares, smirks, double takes, name calling, or, conversely, the conscious effort to pretend that shes not transgender.

The waitress immediately falls into the latter, overdoing the pronouns with too many self-conscious references to ladies and girls, even joking with Maria about Mistys ability to eat like a man without putting on weight.

Shes a skinny bitch, Maria laughs, playfully slapping Misty.

Right? the waitress answers, joking at how just looking at Mistys lunch makes her fat.

Misty smiles indulgently before lifting her burger in both hands and taking a big bite. She cant control the way people react to her, nor does she care. She doesnt expect people to understand.

And though people in Wyoming are less open to diversity, they tend to be pretty laid back when it comes to minding their own business. And while in the urban circles of the hyper-politically correct, transgenders are fighting for pronoun equalitypreferring to be referred to in the third-person as them and they in effort to embrace both sides of their sexMisty isnt carrying any flags.

That said, shes less sympathetic to the name-calling and blatant attempts to pick a fight. She willand hasfought back.

I always tell them that I may look silly but theyre going to look even sillier when they get their ass kicked by a tranny.

Misty, unlike Mark, stays out of the bars. That helps avoid fights, though not entirely.

Misty doesnt exactly mince words. Social skills in general can be a problem for her, she concedes. She blames her Aspergers Syndrome for being too blunt. She sees things as strictly black or white, very little gray; success or failure, nothing in-between.

Misty drops a pen on the table, then lifts it in the air. You either have the ability to pick up or not, she says.

Maria covers her face and shakes her head. Trying means nothing?

Nope.

Maria gives up.

Misty rubs her thumb over a clump of mascara thats fallen under Marias left eye. She holds her chin and rubs gently.

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Transitioning: Controversy, corrections and new-found peace, Misty Lane is finally finding happiness with herself - Douglas Budget

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Top five misconceptions about menopause – Starts at 60

Posted: August 12, 2017 at 10:43 pm

Going through menopause is usually a difficult time for women and there are a lot of physical changes that take place. So often we hear about the hot flushes, sleepless nights and lowered libido. But is it really that bad and what actually happens? Specialist Clinics of Australia owner and clinical director Dr Garry Cussell debunks the top five myths of menopause and sheds light on how to make this time of transition as easy and as possible.

Whilst the average age that women hit menopause is 51 to 52 years old, it can in fact happen to women in their 40s (early menopause) or even younger (premature menopause). Surgery or medical treatments that affect hormones such as chemotherapy and radiation therapy can bring on early menopause or premature menopause. Genetic factors also play a role in determining the age a woman will hit menopause but every woman has her own moment, says Dr Cussell.

Lack of estrogen can cause symptoms such as itchiness, decreased lubrication, and pain during sexual intercourse and incontinence of urine. These symptoms generally appear a few years after the onset of menopause and affect up to 50% of post-menopausal women. Many women believe that the only way to treat these symptoms is with invasive surgery or Hormone Replacement Therapy but these days there are a lot of safe alternatives out there. GynaeLase is a quick, non-invasive and relatively painless laser procedure that relieves these symptoms without surgery or HRT. It encourages renewed functional activity in the treated sections of tissue through a special heat effect. Optimum results are usually achieved after three treatments as the process of collagen neogenesis takes time to develop, with the effect of tissue tightening and collagen build-up increasing after each treatment.

Laxity and atrophy can be bothersome conditions and impact on happiness and sexual function. Even the healthiest of women will experience the natural process of laxity, and this can be exacerbated by child birth or weight gain. GynaeLase helps treat these symptoms and the vast majority of patients at Specialist Clinics of Australia who have undergone the treatment have reported improved sexual activity.

Although hot flushes are one of the most common symptoms experienced by women going through menopause, not all women get them. Its still not clear exactly what actually causes hot flushes but its estimated that four out of five postmenopausal women will experience them. The usual treatment for these is using oestrogen tablets and patches, however these have potential side effects and there are alternative treatments.

Decreased oestrogen levels can impact on your bodys metabolic rate but this doesnt necessarily mean youll gain weight post-menopause. Keeping a balanced diet and exercising regularly will help you manage your weight. If you notice a sudden change in your weight, despite maintaining a healthy lifestyle, talk to your doctor.

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Science and technology to get boost from CRS-12 mission – SpaceFlight Insider

Posted: August 12, 2017 at 10:43 pm

Jim Siegel

August 12th, 2017

A SpaceX Dragon capsule is grappled by the space stations roboticCanadarm2 onApril 10, 2016. (Click for full view) Photo Credit: NASA

CAPE CANAVERAL, Fla. The cargo aboard NASAs scheduled Aug. 14, 2017, commercial resupply mission to the International Space Station (ISS) could help more people than just the six astronauts and cosmonauts currently living there. With more than three tons of experiments and materials being ferried, SpaceXs Dragon capsule promises to benefit people ranging from those suffering from Parkinsons disease, to those seeking bio-engineered organs, to soldiers on the battlefield.

NASA Astronaut Jack Fischer works within the Japanese Experiment Module on CASIS PCG 6. CASIS PCG 7 will utilize the orbiting laboratorys microgravity environment to grow larger versions of Leucine-rich repeat kinase 2 (LRRK2), implicated in Parkinsons disease. Photo & Caption Credit: NASA

In 2008, NASA awarded two contracts one to Orbital Sciences (now Orbital ATK) and one to SpaceX for commercial resupply services to the orbiting lab. At the time of the award, NASA ordered eight flights from Orbital, valued at about $1.9 billion, and 12 flights from SpaceX, valued at approximately $1.6 billion. SpaceX flew its first mission under the contract in October 2012 (Orbital flew its first mission a little over a year later in January of 2014).

The CRS-12 missionis currentlytargeted to launch at 12:31 p.m. EDT (16:31 GMT) on Aug. 14. When it flies, it will mark the 12th ISS resupply mission that SpaceX has carried out (one Commercial Orbital Transportation Services mission and 11 Commercial Resupply Services missions have successfully traveled to the Space Station).

The companys Dragon spacecraft will ride a Full Thrust Falcon 9 rocket, roaring away from Kennedy Space Centers Launch Complex 39A. Assuming an on-schedule launch, the spacecraft should arrive at the ISS on Aug. 16 with some 6,415 pounds (2,910 kilograms) of cargo. Only about a quarter of the manifest will be crew supplies, vehicle hardware, spacewalk equipment, and computer resources.

The remainder of the spacecrafts manifest is comprised of hardware and supplies to support dozens of the approximately 250 science and research investigations that will occur on current and upcoming ISS missions.NASA hosted an Aug. 8 pre-flight science briefing featuring the principal investigators of five of these experiments.

About a third of the CRS-12 cargo mass will be a refrigerator-size package designed to measure dangerous, life-threatening cosmic rays. This project, called the Cosmic-Ray Energetics and Mass investigation (CREAM), features instruments to measure the charges of cosmic rays ranging from hydrogen nuclei up through iron nuclei, over a broad energy range. According to principal investigator Eun-Suk Seo of the University of Maryland Institute for Physical Science and Technology, once the ISS astronauts unpack it, the modified balloon-borne device will be placed on the Japanese Exposed Facility for a period of at least three years.

According to NASA, humans aboard long-duration, deep-space explorations such as those to the planet Mars are thought to likely face serious health consequences from exposure to high-energy galactic cosmic rays, including direct damage to DNA and changes in the biochemistry of cells and tissues.Seo said that people on Earth are protected from these rays by the Earths atmosphere and magnetic field; to the extent that some solar radiation does get through, it is roughly the same as that of starlight.

Mice for NASAs Rodent Research 9 experiment will reside in a Rodent Habitat module while aboard Dragon and the International Space Station. Photo Credit: Dominic Hart / NASA

Even astronauts aboard the ISS are somewhat protected by the Earths magnetic field. However, beyond the outer zone of the Van Allen radiation belt extending 8,100 to 37,300 miles (13,000 to 60,000 kilometers) from Earth long-term exposure is thought to be very serious, according to the space agency.

CREAM experiments conducted in six balloon flights at 25-mile (40-kilometer) altitudes over Antarctica have yielded a limited understanding of galactic cosmic rays. The three-year CREAM mission aboard the space station will significantly expand knowledge of cosmic radiation and what it might take to protect interplanetary travelers in the future.

As many as 1 million Americans live with Parkinsons disease, with a worldwide total thought to exceed 10 million. One of the experiments aboard CRS-12 is aimed at helping to find a cure for this affliction.

One aspect of Parkinsons under investigation involves a protein called LRRK2. Defining the shape and morphology of this protein would help scientists better understand the pathology of the disease and aid in the development of effective therapies that might slow or stop the progression of this neurodegenerative disorder. Unfortunately, according to Marco Baptista, director of research and grants for the Michael J. Fox Foundation, Earth-grown versions of the LRRK2 protein are too small and too compact to study.

However, Baptista and other principal investigators from the University of Oxford, Goethe-University (Frankfort), and the University of San Diegobelieve that versions of the protein grown in microgravity may be larger and better-defined, lending themselves to detailed analysis. Aboard the ISS, a CASIS PCG 7 automated biotechnology device will produce samples of the LRRK2 protein.

The project hardware includes a Microlytic Crystal Former Optimization Chip (16 Channel) plate. It will be launched frozen and then transitioned to ambient temperature on the ISS to start the nucleation and crystallization process. Following a growth period of up to 21 days, the hardware will be moved to refrigerated storage for the return flight to Earth for detailed laboratory analysis.

Another experiment aboard CRS-12 is focused on helping solve health problems, this one relates to the use of stem cells to grow replacement lung tissue in patients with lung diseases or conditions.

Joan Nichols, a professor of internal medicine and infectious diseases and Associate Director of the Galveston National Laboratory at the University of Texas Medical Branch (Galveston), provided a brief explanation. According to Nichols, the cells will be flown live in tissue culture bags to the ISS via conditioned stowage assets at 98.6 degrees Fahrenheit (37 degrees Celsius) within BioCell Habitat containers. Once on board, the BioCell habitats will be placed inside chambers that should provide temperature and carbon dioxide control for the cell cultures.

Kestrel Eye will test the possibility of building and launching clusters of small, relatively inexpensive satellites that have sufficient optical capability to provide useful, real-time information over an extended period of time. Photo Credit: U.S. Army

The cells will be cultured for approximately five weeks with periodic sampling. Once the cultures have grown for a predetermined amount of time, a 4.5-milliliter sample will be pulled from the bag and frozen at minus 176 degrees Fahrenheit (minus 80 degrees Celsius) for the remainder of the flight and then minus 68 degrees Fahrenheit (minus 20 degrees Celsius) or colder for return. The cells remaining within the bags will also be stored for the return flight.

The stem cells wont be the only live cargo aboard CRS-12. As was explained by Michael Delp, principal investigator for Rodent Research-9 from the Florida State University, 20 mice will be the focus of an investigation related to musculoskeletal and neurovascular systems of astronauts in long-term interplanetary travel. Delp noted how this experiment is aimed at three particular biomedical aspects: visual impairment caused by lack of sufficient movement of fluids in the brain; fluid movement into and out of the brain; and biomechanical movement, especially in cartilage tissue.

Delp said that rather than collecting data from the mice, the plan will be to observe their behavior with video monitoring. Further, he said the mice would be brought back alive for a splashdown in the Pacific Ocean and then rushed for observation and evaluation to the office of Xiao Wen Mao, one of the co-investigators, at Loma Linda University.

One final project covered during the Aug. 8 science briefing involves space-based support for the military.

Chip Hardy, Kestrel Eye program manager for the U.S. Army Space and Missile Defense Command Army Forces Strategic Command, presented an overview of providing real-time information to ground troops regarding enemy location and movement. Currently, there are military satellites that can provide fairly detailed visual images or video. However, these satellites are very expensive, relatively few in number, and provide useful information only if in the proper orbital attitude.

The NanoRacks-SMDC-Kestrel Eye IIM project will test the possibility of building and launching clusters of small, relatively inexpensive satellites that have sufficient optical capability to provide useful, real-time information over an extended period of time. According to the NASA media briefing release, it is a monolithic design, with dimensions of 15 inches 15 inches 38 inches (38 centimeters 38 centimeters 96.5 centimeters) with integrated command data and handling system, attitude controls and solar arrays for power. The primary payload is a medium resolution electro-optical imaging system, an element of which is a commercial off-the-shelf (COTS) telescope.

Following an anticipated October 2017 deployment using the ISS NanoRacks Kaber deployer, the NanoRacks-KE IIM will begin its nominal mission operations limited by its expected six-month orbital lifetime.

There may also be civilian applications for this potential optical platform, such as to monitor the weather or natural disasters.If this test is successful, Hardy noted that the next step might be one of a number of alternatives, including a low-volume production run or the substitution of a different optical technology.

Many organizations and teams of students have seen their experiments fly to the International Space Station, one of them, DASA, is looking forward to having their experiment travel to the International Space Station as part of CRS-12s payload.

To see an idea that started a few months ago as a sketch on a piece of paper actually takeshape and fly to space is a rare opportunity, DASA team member KatherineStecher said via a release. The anticipation has definitely built, and I cant wait to see what answers ourexperiment brings back.

Video courtesy of the Center for the Advancement of Science In Space

Tagged: CRS-12 Dragon International Space Station Lead Stories NASA SpaceX

Jim Siegel comes from a business and engineering background, as well as a journalistic one. He has a degree in Mechanical Engineering from Purdue University, an MBA from the University of Michigan, and executive certificates from Northwestern University and Duke University. Jim got interested in journalism in 2002. As a resident of Celebration, FL, Disneys planned community outside Orlando, he has written and performed photography extensively for the Celebration Independent and the Celebration News. He has also written for the Detroit News, the Indianapolis Star, and the Northwest Indiana Times (where he started his newspaper career at age 11 as a paperboy).Jim is well known around Celebration for his photography, and he recently published a book of his favorite Celebration scenes. Jim has covered the Kennedy Space Center since 2006. His experience has brought a unique perspective to his coverage of first, the space shuttle Program, and now the post-shuttle era, as US space exploration accelerates its dependence on commercial companies. He specializes in converting the often highly technical aspects of the space program into contexts that can be understood and appreciated by average Americans.

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