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Case Western Reserve University Researchers Develop Therapeutic to Enhance Tissue Repair and Regeneration – Newswise (press release)

Posted: August 8, 2017 at 6:42 pm

Newswise Rodeo Therapeutics, a new drug development company created by two highly regarded Case Western Reserve University School of Medicine researchers, has raised $5.9 million to develop small-molecule drugs that promote the bodys repair of diseased or damaged tissues.

The company is based on discoveries by its three scientific founders, Sanford Markowitz, MD, PhD, Markowitz-Ingalls Professor of Cancer Genetics and Distinguished University Professor at CWRU; Stanton L. Gerson, MD, Asa and Patricia Shiverick- Jane Shiverick (Tripp) Professor of Hematological Oncology and director of the Case Comprehensive Cancer Center; and Joseph Ready, PhD, professor of biochemistry at University of Texas Southwestern. The Rodeo moniker is intended to invoke the western in Case Western Reserve and University of Texas Southwestern, home universities of the firms three co-founders.

The company will build on its founders research expertise to develop drugs to help the body heal itself by inhibiting a prostaglandin-degrading enzyme called 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Prostaglandins are hormone-like substances crucial for many important activities within the body.

In a 2015 publication in Science, Markowitz, Gerson, and Ready showed that prostaglandins stimulate the ability of tissue stem cells to repair tissue injury, and that this activity could be potently activated by small molecules they developed to inhibit 15-PGDH. In mice models, the 15-PGDH inhibitors stimulated healing of colitis, stimulated recovery of the liver following liver surgery, and markedly accelerated the recovery of bone marrow after a bone marrow transplant.

The body has enormous potential to heal itself through actions such as tissue regeneration, Markowitz said. Our goal was to develop a drug that could recruit these tissue regeneration capacities to assist in treatment of human diseases where tissue damage is often the principal cause of death or significant illness.

Accelerator Corporation, a Seattle-based life science investment and management firm, led the effort in obtaining a $5.9 million Series A financing for Rodeo Therapeutics. Investors include AbbVie, Alexandria Venture Investments, Arch Venture Partners, Eli Lilly & Company, Johnson & Johnson Innovation JJDC, Inc., Watson Fund, L.P., WRF Capital, and WuXi AppTec. Accelerator will help manage the new firm along with Rodeos three scientific founders.

Rodeo Therapeutics founding scientists have achieved a level of biology and medicinal chemistry for their lead product candidate that is advanced beyond what we would typically see in an academic setting, said David M. Schubert, chief operating officer of Accelerator. We believe that this Series A investment will provide the financial resources to rapidly advance the companys development program toward human trials, opening the door to an exciting new therapeutic approach that has significant clinical and commercial potential.

Inflammatory diseases often result in serious tissue damage and impairment, Gerson said. We have developed a drug that has stimulated tissue regeneration, repairing damage to the colon, liver, and bone marrow in animal models, paving the way to apply our findings to human diseases.

Rodeo will focus on increasing tissue levels of prostaglandin E2, or PGE2. Research has shown that PGE2 supports production of many types of tissue stem cells, which are crucial for healing to occur. Markowitz and University of Kentucky Professor Hsin-Hsiung Tai earlier showed that 15-PGDH degrades and reduces the amount of PGE2 in the body and that inhibiting 15-PGDH leads to more PGE2 being produced, resulting in tissue regeneration and healing.

Markowitzs laboratory developed a test for identifying drugs that could bind to 15-PGDH. Ready and his UT Southwestern colleague, James Willson, MD, (former director of the Case Comprehensive Cancer Center), used the test to examine a repository of over 230,000 chemicals, finding one SW033291that incapacitated 15-PGDH when added at one part in 10 billion in a test-tube-based mixture, raising the possibility that it could be administered as a drug.

Markowitz, Gerson and their colleagues then studied mice that had received lethal doses of radiation, followed by a partial bone marrow transplant. Without SW033291, all the animals died. With it, they all recovered. Additional studies showed that mice given the drug regained normal blood counts six days faster than mice that were transplanted without receiving the drug.

In addition, the researchers found that SW033291 accelerated tissue recovery in other diseases, for example, healing virtually all ulcers associated with ulcerative colitis. In mice that had two-thirds of their livers surgically removed, SW033291 accelerated re-growth of new liver nearly twice as fast as typically happens without the medication. Crucially, there were no adverse side effects, even at doses much higher than needed for inhibiting 15-PGDH.

The new funding for Rodeo will enable the founders to conduct studies aimed at showing the safety of SW033291-related compounds in larger animals, part of the pathway needed to secure approval from the U.S. Food and Drug Administration for trials in humans. The first focus is on developing 15-PGDH inhibitors for inflammatory bowel disease and promoting the reconstitution of blood cells following bone marrow transplant.

This team and this program provide a blueprint for what can be accomplished with translational research in Cleveland, said Michael Haag, Case Western Reserves executive director of technology management at CWRUs Technology Transfer Office. We are indebted to several advisors who provided world-class guidance and mentorship.

Translational Research Support for the founders research on developing 15-PGDH inhibitor drugs came from Case Western Reserves Council to Advance Human Health, University Hospitals Cleveland Medical Centers Harrington Discovery Institute. Also contributing to the technology development to date was a grant from the NIH Center for Accelerated Innovation Cleveland Clinic (NCAI-CC), a multi-institutional NIH-funded technology development program focused on translating promising research to commercial development and eventual use in the diagnosis and treatment of patients.

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About Case Western Reserve UniversityCase Western Reserve University is one of the country's leading private research institutions. Located in Cleveland, we offer a unique combination of forward-thinking educational opportunities in an inspiring cultural setting. Our leading-edge faculty engage in teaching and research in a collaborative, hands-on environment. Our nationally recognized programs include arts and sciences, dental medicine, engineering, law, management, medicine, nursing and social work. About 5,100 undergraduate and 6,200 graduate students comprise our student body. Visitcase.eduto see how Case Western Reserve thinks beyond the possible.

For more information about Case Western Reserve University School of Medicine, please visit: case.edu/medicine.

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Case Western Reserve University Researchers Develop Therapeutic to Enhance Tissue Repair and Regeneration - Newswise (press release)

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Cancer survivor meets bone marrow donor days before wedding – WBNG-TV

Posted: August 8, 2017 at 6:42 pm

BINGHAMTON (WBNG) -- Thursday, a cancer survivor met her bone marrow donor for the first time, just days before her wedding.

"They told me that without a transplant I really only had about six months to a year," said Vivian Nolan, a bone marrow transplant recipient.

In 2008, Vivian Nolan was diagnosed with a rare form of cancer called multiple myeloma. Later on, she was diagnosed with leukemia.

Doctors tried a bone marrow transplant with her own stem cells. When that didn't work, they said she needed a donor.

"The only cure or chance of holding it off at all is a bone marrow transplant," Nolan said.

Lucky for Nolan, doctors found a match.

A stranger volunteered to save her life. Scott Durbin is Nolan's donor. He lives in Kentucky, over 850 miles away.

Thursday, Durbin and Nolan met for the first time.

Nolan is getting married on Saturday.Durbin and his family flew in to support her in her next phase of life, a life that she wouldn't have without him.

"This is the man who gave me my life back. So I'm really happy," Nolan said.

For Durbin, the decision to help someone in need was second nature.

"I signed up. 7 months later I got that phone call saying they was gonna fly me to Atlanta," bone marrow donor Scott Durbinsaid.

Nolan was still in shock that someone would do something so kind for a person he had never met.

"I just couldn't believe that there was someone out there that I never knew that would go through that for me," she said.

After the transplant, Nolan wanted to meet the man who now is a part of her.

Today, she was able to introduce her family to its newest member.

"Now I've got this whole new life and he's got this whole big new family."

For Durbin, it's a choice he'd make over and over.

"I would do it again to give you a second chance," Durbin said.

Nolan remains forever grateful for that second chance.

Since her bone marrow transplant, Nolan's leukemia is virtually gone. She says she feels great, and can't wait for her new lease on life.

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Cancer survivor meets bone marrow donor days before wedding - WBNG-TV

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Dramatic Burn-Healing Through Stem Cell Treatment – Fox Weekly

Posted: August 8, 2017 at 6:41 pm

A med-tech startup has developed a fast and easy way to treat certain burn wounds with stem cells. This technology is developed by German researcher Dr. Jrg Gerlach. He is the worlds first ever person who use a patients stem cells to directly heal the skin. The technique is meant to reduce the healing time and minimize complications, with aesthetically and functionally satisfying outcomes. There are no scars, no residual pain and its like there wasnt any burn to start with. Its not less than a miracle.

The medical technology startup has now transformed the proof-of-concept device from a complicated prototype into a user-friendly product called a SkinGun, which it hopes doctors will be able to use outside of an experimental setting. RenovaCare CEO Thomas Bold believes, the SkinGun can compete with, or even replace, todays standard of care. The sprayer allows us to have a generous distribution of cells on the wound, explained Roger Esteban-Vives, director of cell sciences at RenovaCare.

RenovaCares SkinGun sprays a liquid suspension of a patients stem cells onto a burn or wound in order to re-grow the skin without scars. Stem-cell methods helped cut this risk by quickening healing and providing a source of new skin from a very small area. Cell Mist method gets a greater yield from its harvest than mesh grafting, a more common way to treat burns. At a maximum, grafting can treat six times the size of its harvest area. Cell Mist can cover 100 times its harvest area.

When dispensing cells over a wound, its important that they make the transition without any damage. Damaged cells reduce the effectiveness of the treatment.

High cell viability also contributes to faster healing. When a wound heals naturally, cells migrate to it to build up the skin. That process can take weeks.

Stem cells have tremendous promise to help us understand and treat a range of diseases, injuries and other health-related conditions.

There is still a lot to learn about stem cells, however, and their current applications as treatments are sometimes exaggerated by the media and other parties who do not fully understand the science and current limitations

Beyond regulatory matters, there are also limitations to the technology that make it unsuitable for competing with treatments of third-degree burns, which involve damage to muscle and other tissue below the skin.

When burn victims need a skin graft they typically have to grow skin on other parts of their bodies. This is a process that can take weeks. A new technique uses stem cells derived from the umbilical cord to generate new skin much more quickly.The umbilical cord consists of a gelatinous tissue that contains uncommitted mesenchymal stemcells (MSC)

Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenertive diseasesand conditions such as diabetes, heart disease, and other conditions.

Tens of thousands of grafts are performed each year for burn victims, cosmetic surgery patients, and for people with large wounds having difficulty healing. Traditionally, this involves taking a large patch of skin (typically from the thigh) and removing the dermis and epidermis to transplant elsewhere on the body. Burns victims are making incredible recoveries thanks to a revolutionary gun that sprays stem cells on to their wounds, enabling them to rapidly grow new skin. Patients who have benefited say their new skin is virtually indistinguishable from that on the rest of the body.

Thomas Bold, chief executive of RenovaCare, the company behind SkinGun, said: The procedure is gentler and the skin that regrows looks, feels and functions like the original skin.

If you are planning to have stem cell treatments dont forget to remember these points

Stem cell researchers are making great advances in understanding normal development. They are trying to figure out what goes wrong in disease and developing and testing potential treatments to help patients. They still have much to learn. However, about how stem cells work in the body and their capacity for healing. Safe and effective treatments for most diseases, conditions and injuries are in the future.

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Stem cells: science prepares to take the first sip from the real fountain of youth – Catholic Online

Posted: August 8, 2017 at 6:41 pm

Theoretically, eternal youth is now within our grasp.

Doctors are close to discovering a real life fountain of youth that could theoretically enable patients to live forever. Advances in stem cell treatments and now, tissue nanotransfection (TNT), which is a new technique, can theoretically provide patients with the benefits of youth for life.

The fountain of youth is within the grasp of science, but so far, only for mice. Human trials come next year.

LOS ANGELES, CA (California Network) -- The quest for eternal life is ancient. It is mentioned in the first and oldest story we have, the Epic of Gilgamesh. In that ancient Sumerian tale, only Utnapishtim, a man who built and ark and survived a great flood in a story that is almost identical to the story of Noah's ark, knows the secret to eternal life, which ultimately proves elusive. In the centuries that followed, people have tried every remedy imaginable to prolong life. They searched for the fabled fountain of youth, and according to some legends, bathed in the blood of virgins and children.

Today, we know none of these endeavors would work because ageing is carried on in the genes. The only way to reverse ageing is to manipulate the genes. And this is precisely what doctors are looking to do in order to produce new cells, and even whole organs.

Researchers now know the primary difference between a young person and an old person is the number of stem cells in their body. Young people have many times more stem cells. This is the basic, underlying reason why young people are so youthful. A young body can repair itself more rapidly and thoroughly than an older one because of the number of stem cells. But if stem cells could be injected into an older body, in quantities similar to those enjoyed by a young person, what would happen then?

Nobody knows for certain because the experiment hasn't been conducted, but the hypothesis is that the older person would become more youthful, healthier, and longer lived.

As stem cells enter the medical mainstream, and may become a standard part of medical treatment in the near future, there is another development that could make stem cells irrelevant. Nanotransfection, abbreviated as TNT, is a new method whereby skin cells can be turned into any other cell in the body using a special microchip and electricity.

The device, called a nanochip, is loaded with genetic material essential to turning cells into other kinds of cells. The electrical current enables the device to inject the genetic material into the skin where it ends up inside the cells. These cells can then travel though the body and take on the properties of healthy cells around damaged tissue, facilitating repair. On other words, a damaged liver or heart can be repaired with this tiny device. The advantage of this method is that stem cells are not required. Your skin cells simply become whether other kind of cells they are told to become by the injected genetic material.

A study affirming the effectiveness of this approach was published in the journal, Nature Nanotechnology. It has been tested on mice and was successful in restoring function to non-functioning limbs. It will be tested on humans within the next year.

Scientists have known they can reprogram cells into other kinds of cells for a long time now, but only recently have they developed the method to do so cheaply and efficiently. The actual procedure requires a chip that is as small as a penny, and takes only a second to work.

If the procedure works on humans, then doctors may have a cheap and efficient way to repair and even replace organs. The discovery is so dramatic is it difficult to believe. More testing is required, but it shows just how far we have come in our ability to edit genes and reprogram cells to grow specific forms of tissue within the body.

In a generation or less, it is reasonable that we will have unlocked the secret to reversing ageing. Of course, this discovery opens a whole host of ethical and philosophical questions, but that's for the ethicists and politicians to work out. For now, science is about to take the first sip from the fountain of youth, and we await the result.

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Pope Francis Prayer Intentions for JULY 2017Lapsed Christians. That our brothers and sisters who have strayed from the faith, through our prayer and witness to the Gospel, may rediscover the merciful closeness of the Lord and the beauty of the Christian life.

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Stem cells: science prepares to take the first sip from the real fountain of youth - Catholic Online

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Epigenetics and Cancer 2017 | Epigenetics Conferences …

Posted: August 8, 2017 at 6:41 pm

Sessions & Tracks

Track 1 : Cancer

Canceris an abnormal growth of cells which have a tendency to multiply in an uncontrolled way. They have a property to metastasize. The branch of medicine that deals with the prevention, diagnosis and treatment of Cancer is called Oncology.

RelatedOncology Conferences|Cancer Conferences|Cancer meetings

16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK.

Track 2 : Types of Cancer

Cancers are classified and named depending upon the type of cell they originated and have different forms. Some examples are as follows:

RelatedCancer meetings |Oncology Conferences|Cancer Conferences

9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; 16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK.

Track 3 : Cancer Genetics

Certain changes to genes can alter and control the functioning of the body cells, their growth and division. This causesCancer.

Cancercausing genetic changes :

RelatedCancer Conferences|Cancer meetings|Oncology Conferences

Track 4 : Cancer : Diagnostics and Staging

Canceris suspected in a view of a persons symptoms ,screening tests. Affirmation thatCanceris present requires diagnostic tests which is followed by staging. Staging is way of analysing the tumor, its size, location and the treatment depending on theCancerstage.It helps to determine the Prognosis of the patient i,e treatment prediction ,disease outcome and patients recovery chances.

RelatedCancer Conferences|Cancer meetings|Oncology Conferences

Track 5 : Cancer: Treatment and Therapy

There are many sorts ofCancertreatment. The treatment varies depending on the type of Cancer and its stage.The following are the main types ofCancertreatment :

Related Oncology Conferences|Cancer Conferences|Cancer meetings

InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK;16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA;.

Track 6 : Cancer Stem Cells

Cancer Stem Cells areCancercells present in the tumors. They possess the normal stem cells characteristics i,e their ability to proliferate into different cell types by differentiation.Cancer stem cells are tumorigenic and develops tumors. They also lead to metastasis and relapse thus giving rise to the formation of new tumor cells.Hence there is a need to develop specific therapies targeted at Cancer stem cells to increase the chances of survival of Cancer patients.

Related Cancer Conferences|Cancer meetings|Oncology Conferences

Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK;16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain;

Track 7 : Cancer Epigenetics

The study of epigenetic modifications to theCancercells genome is calledCancer Epigenetics, that does not bring a change in the nucleotide sequence. Risk expectation and prediction andCancerprevention, growth counteractive action are also promising and encouraging areas of Epigenetics.A high adequacy of demethylating agents were accounted for essentially in hematological malignancies in view of new conventions with low dose and long exposure, and their utilization is presently being striven for strong tumors.

During the cellstransformation to Cancerous cell, Epigenetic modifications are also mor important like genetic mutations. Their manipulation brings a great promising approach to for preventing , detecting and therapy of Cancer.

RelatedOncology Conferences|Cancer Conferences|Cancer meetings

19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France;16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK.

Track 8 : Epigenetics

Epigeneticsdeals with the study of heritable changes in gene , that does not include changes to the basic DNA arrangement an adjustment in phenotype without an adjustment in genotype which influences how cells read the genes.Epigeneticschange is a normal, natural and characteristic occurence yet can likewise be affected by a few factors including age, the environment/lifestyle, and illness state. Epigeneticsmodifications can show as normally as the way in which cells terminally separate to differentiate as liver cells, skin cells, etc.Alternately, epigenetic change can have all the more harming impacts that can bring illnesses, disease.

example :Cancer.

RelatedCancer Conferences|Cancer meetings|Oncology Conferences

Track 9 : Developmental and Nutritional Epigenetics

Epigeneticfactors are also called as epigenetic marks control many functions of cells in our bodies. From time to time,Epigeneticmarks cause certain genes to be turned on or off at various phases of the body's development and growth in a way that prompts to a disease onset

In this way, researchers and scientists have been able to find the thin line which is connecting the following diseases to Epigenetics

This track also deals with the modifications and changes that greatly affects the processes such as DNA methylation and histone modifications like embryonic development, aging, and carcinogenesis

Epigenetics plays a key role in wide range of diseases like type 2 Diabetes Mellitus, Obesity, inflammation, and neurocognitive disorders. Nutritional Epigenetics can be considered as an attractive tool to anticipate and prevent Cancer and pediatric developmental diseases

Related Cancer Conferences|Cancer meetings|Oncology Conferences

16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan; 15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK.

Track 10 : Transgenerational Epigenetic inheritance

Transgenerational epigenetic inheritance is the transmittance of information from one generation to another ,for example :from a parent to child.This affects the offspringstraits without changing the primary structure of DNA.In multicellular organisms the epigenetic inheritance has different mechansisms.

RelatedOncology Conferences|Cancer Conferences|Cancer meetings

Track 11 : Epigenetics - Neurodevelopmental and Neurodegenerative disease

Neurodegenerative disorders are among the major difficulties and among the most medical issues that should be withstanded by the world, particularly in light of expanding population age. They cause the degeneration and death of nerve cells as they form incurable conditions for treatment. According to a collaborative study of the WHO, the World Bank and the Harvard School of Public Health by 2020 neurodegenerative diseases,dementia will be the eighth cause of disease among developed regions.It is also estimated that they will occupy the worlds second leading cause of death by 2050, overtaking Cancer During embryogenesis and for differentiation of neural cells Epigenetic mechanisms are essential required. Thus, precise understanding of epigenetic mechanisms, including DNA methylation and histone modification, is important to elucidate the pathogenic pathways in neurodevelopmental disorders

Most common neurodegenerative diseases

RelatedCancer meetings|Oncology Conferences|Cancer Conferences

Track 12 : Epigenetic Diseases, Clinical Applications , Pharmacogenomics

This particular track deals with the onset of diseases and the required clinical applications and theraphy related to those diseases.

Pharmacogenomics is a combination of pharmacology and genomics.this branch of study is concerned with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacodynamics and pharmacokinetics. The genetic disorder occurrence is quite rare in polutaion.Some might be hereditary while the others are caused by mutations.

RelatedCancer meetings|Oncology Conferences|Cancer Conferences

Track 13 : Biomarkers and Bioinformatics Development in Epigenetics

Histones and DNA are chemically altered with epigenetic markers. They influence chromatin structure by changing the electrostatic nature of the chromatin or by altering the affinity of chromatin-binding proteins. DNA can be modified by methylation of cytosine bases

This track also deals with Bioinformatics role inEpigenetics.This branch is expected to make significant contributions to Epigenetics research. Studies in computational Epigeneticsinvolves the improvement and utilization of bioinformatics strategies for resolving the epigenetic questions, and in addition computational information examination and hypothetical displaying with regards to Epigenetics. This incorporates the effects of histone and DNA CpG island methylation.

Related Oncology Conferences|Cancer Conferences|Cancer meetings

15th WorldCongress on Cancer Therapy(977th Annual Conference) December 05-07, 2016 Philadelphia, Pennsylvania, USA; 8th International Clinical Research andBiomarkers Conference, December 05-07, 2016 Philadelphia, Pennsylvania, USA; InternationalConference on Epigenetics2017, November 13-15, 2017 Frankfurt, Germany; 19thWorld Cancer Conference, Nov 21-23, 2017 London, UK; 11th InternationalConference on Leukemiaand Hematologic Oncology December 04-05, 2017 Madrid, Spain; Medical ExpoCongress on Cancer Drugsand Therapeutics, Sep 11-13, 2017 Paris, France; Global Expertsmeeting on OncologyCase Reports Aug 29-31, 2017 London, UK; 2ndCancer Diagnostics Conference& Expo, May 8-10, 2017 Barcelona, Spain; 9th InternationalConference Cancer BiomarkersAugust 23-24, 2017 Birmingham, UK; 16th Global AnnualOncologistsMeeting, April 24-25, 2017 Dubai, UAE; Global Summit onOncology & Cancer, May 25-27, 2017 Osaka, Japan,; InternationalConference on Cancer Diagnostics, November 27- 28, 2017 Dubai, UAE;9th InternationalCancer Biomarkers Conference, August 07-09, 2017 Osaka, Japan.

Track 14 : Epigenomic Effects of Environmental Exposures

Environmental contaminants and toxicants are far reaching all through the world, and can incorporate different materials and chemicals, from by results of ignition to contaminationg trace metals and organic natural mixes utilized as a part of day by day life. Presentation to changing sums and sorts of these contaminants is connected to impacts on human wellbeing .The fields of natural wellbeing and toxicology have concentrated on bettering the comprehension of how these contaminants affect biological prcocesses so that their wellbeing effects can be lessened or anticipated.

Numerous diseases are brought about by various types of alterations among dfifferent genes. Some of these progressions are hereditary changes that are passed along in families while some are mutations that happen due various hazardous environmental factors .

RelatedOncology Conferences|Cancer Conferences|Cancer meetings

Track 15 : World Cancer Market

Oncology Market is increasing and will be paced on a wide scale.The world wide oncology market is expected to grow in upcoming years due to expanded industry R&D and high investments by multinational companies in the Cancer research.

Related Oncology Conferences|Cancer Conferences|Cancer meetings

Track 16 : Entreprenuers Investment Meet

A stage planned to associate Entrepreneurs, Proposers and the Investors around the world. It's expected to make and encourage the most streamlined and reasonable meeting place for drawing in individuals in worldwide business disdcussions, assessment and execution of promising business thoughts. A financial specialist might discover the most astounding potential venture openings all around, which give great quantifiable profit. For business visionaries, this would be a perfect place to discover appropriate speculators and accomplices to begin or potentially extend their business. Hence it is an impeccable place to associate Entrepreneurs, Business Owners, Early Stage Companies and Established Corporates with National or International Investors, Corporate Investors and Potential Business Partners.

Related|Oncology Conferences|Cancer Conferences|Cancer meetings

In the last few years, the market forCancerprofiling in Asia-Pacific region has seen huge development as a result of increasing incidence ofCancer, high demand for better healthcare services .

High prevalence ofCancer; expanding R&D subsidizing; expanding power of research exercises; expanding application for non-oncology illnesses; and developing organization between scholarly, biotechnology and pharmaceutical organizations are driving components of theCancergenomics and epigenetics market

CancerProfiling Market is divided by Application ,Diagnosis, Technique, Technology etc.

ByApplicationit consists of :

Diagnostic,

Personalized Medicine,

Research.

By Technique, it consists of :

Genomics,

Proteomics,

Metabolomics,

Epigenetics.

By Technology, it consists of :

It is estimated that the worldwide Cancer Profiling business sector is ready to achieve USD 61.87 Billion by 2021 from USD 25.82 Billion in 2016 according to the "Cancer Profiling Market".The following graph depicts the data pictorially.

Central point powering market development are increasing number of malignancy cases over the globe.

Components, for example, the expanding interest for personalized medicine and point-of-care diagnostic tests inCancerprofiling are required to offer an extensive variety of development open doors for players in the tumor profiling market. The personalized medicine segment to represent the biggest share of the worldwide cancer profiling application showcase in 2016.

Across the board continuous research in the part ofEpigeneticsin diseases and disorders in humans is fuelling the worldwide epigenetics drugs, diagnostic technologies and indicative advances.

In light of research territories, the market for Epigenetics is fragmented into developmental biology, drug discovery, oncology and other research areas. Other research areas include genome-wide regulatory mechanisms and research related to several metabolic and genetic diseases.

In light of geology, the market of Epigenetics is divided into North America, Europe, Asia, and the Rest of the World. North America is further sub-segmented into U.S. furthermore, Canada. In Asia, the degree for this present market's development is extending quickly. Asia represents about a large portion of all cancer cases analyzed around the world. This makes helpful conditions for the development of the Epigenetic medications and diagnostics advertise in Asian nations, particularly China, Japan, Australia, and South Korea, with Japan in theprevailing position.

As per the National Cancer Institute, malignancy is among the main sources of death around the world, for which according to a recent review, epigenetic inhibitors comprise of the attributes and capacities which have the potential in cancer prevention and control. This element has given an impulse to the examination directed on epigenetics in the oncology business

In the estimated period between 2015 to 2020 the Epigenetics market is relied upon to stay as the quantity of new participants in this market will continue ascending with the consistent appearance of new innovations combined with upgraded highlights.

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Epigenetics and Cancer 2017 | Epigenetics Conferences ...

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Epigenetics 2017 | Epigenetics | Epigenetics Conference | CME …

Posted: August 8, 2017 at 6:41 pm

Session/ Tracks

Conference series LLC invites all the participants and attendees from all over the world to attendThe 2nd International Congress onEpigenetics & ChromatinduringNovember 06 - 08, 2017which is the only bench to bedside review of the drug discovery and development process.

The live format of this educational activity will be accredited with CME and CPD Credits

It will help scientific leaders from academia, pharma and biotech drive advances in novel epigenetic based therapeutics through the latest updates in pre-clinical and clinical translational research from oncology to new exciting disease areas.

Join us inFrankfurt, Germanyto delve deeper into mechanistic understanding, lead compound discovery and development, and methods for forging and promoting collaboration to achieve the translational progression of the next wave of epigenetic therapeutics.

Attendance at this meeting will enable you to:

Be part of a rich scientific programme incorporating the latest developments in preclinicalGenetic Disorders

Understand the shift towards prevention and early diagnosis ofGenetic Disordersas the future of research in the field

Join key opinion leaders in discussing regulatory and ethical implications of this research in clinical practice.

Network with speakers and other leading experts across disciplines.

Track 1.Epigenetics

Epigeneticsrefers to heritable changes in gene expression that occur without alteration in DNA sequence. These changes may be induced spontaneously, induced by environmental factors or as a consequence of specific mutations. There are two primary and interconnected epigenetic mechanisms:DNA methylationand covalent modification of histones.

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World Congress onHuman GeneticsNovember 07- 08, 2016 Barcelona, Spain; 12th EuroBiotechnologyCongress November 7-9, 2016 Alicante, Spain; 13thBiotechnologyCongress November 28-30, 2016 San Francisco, USA; Global Congress onTissue Engineering and Regenerative MedicineDecember 01-02, 2016 San Antonio, USA; International Conference on Clinical andMedical GeneticsDecember 01-02, 2016 Atlanta, USA; International Conference onGenetic CounsellingandGenomic MedicineDecember 07-08, 2016 Madrid, Spain; 8th World Congress and Expo on Cell &Stem Cell ResearchMarch 20-22, 2017 Orlando, Florida, USA; 7th International Conference onPlant GenomicsJuly 03-05, 2017 Bangkok, Thailand; 3rd International Conference on Systems andSynthetic BiologyJuly 20-21, 2017 Munich, Germany; 3rd International Conference & Exhibition onTissue PreservationandBio bankingAugust 23-24, 2017 San Francisco, USA