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Looking Back: June 9, 2017 – Fairbanks Daily News-Miner

Posted: June 9, 2017 at 9:46 am

10 YEARS AGO

June 9, 2007 Alaskas congressional delegation continues to support legislation that would give the federal government more opportunities to fund embryonic stem cell research.

Rep. Don Young voted in favor of the Stem Cell Research Enhancement Act of 2007 on Thursday, which would make federal funds available to research projects using excess embryonic stem cells that have been donated to an in vitro clinic, and would otherwise be discarded.

The House voted 247-176 in favor of the bill, which has been sent to President Bush.

25 YEARS AGO

June 9, 1992 Fairbanks Mayor Wayne Nelsons sweeping four-part plan to cut the costs of city government and generate revenues survived its introduction to the city council Monday.

The council voted unanimously to advance ordinances calling for the closure of the Fairbanks Fire Department, the creation of a city-run lottery, the appointment of a revenue commission and the opening of the citys labor negotiations to the public.

50 YEARS AGO

June 9, 1967 Fairbanks could receive live television programming from communication satellites within 18 months, Alaskas broadcasters were told yesterday.

Maj. Gen. George P. Sampson, USA-Ret., vice president for operations with Communications Satellite Corp., described the rapidly developing future of satellite communication to a luncheon meeting of the Alaska Broadcasters Association here yesterday.

75 YEARSAGO

June 9, 1942 The million miles which Al Jolson has been promising since 1909 to walk for one of his mammys smiles was never closer to an accurate figure today.

At least 900,000 miles, by his own calculation, from the spot where he knows the sun shines best the dynamic song and patter man of stage, screen, and radio strolled the streets of Fairbanks, making mental notes of his first view of life in Alaska while marking time before the first performance of his Keep em Smilin tour of the Territorys Army encampments.

Before most of the men in Uncle Sams new Army were born Al Jolson was already dubbed one of the greatest dominators in the theater. And, years before that, he had shucked off the name he brought with him to the United States from his native Russia as a boy of seven Asa Yoelson and turned his aspirations from that of becoming a cantor.

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Wolf evolution and ‘settled science’ – Phys.Org

Posted: June 9, 2017 at 9:46 am

June 9, 2017 by Ricki Lewis, Phd, Plos Blogs A coyote (Canis latrans)

Are the red and eastern wolves separate species, or hybrids with coyotes? And what has that got to do with climate change? Actually a lot, in illustrating what scientific inquiry is and what it isn't.

Comparing canid genomes

A report in this week's Science Advances questions conclusions of a 2016 comparison of genome sequences from 28 canids. The distinction between "species" and "hybrid" is of practical importance, because the Endangered Species Act circa 1973 doesn't recognize hybrids. But DNA information can refine species designationsor muddy the waters.

At first, genetic marker (SNP) studies hinted at a mixing and matching of genome segments among coyotes, wolves, and dogs. Then came full-fledged genome sequencing.

Last year Bridgett M. vonHoldt, head of Evolutionary Genomics and Ecological Epigenomics at Princeton and colleagues, scrutinized the 28 full genome sequences for signs of "lack of unique ancestry." They compared the genomes of 3 domestic dog breeds (boxer, German shepherd, and Basenji), 6 coyotes, a golden jackal from Kenya, and various wolves to 7 "reference" genomes from 4 Eurasian gray wolves (to minimize recent mutations) and 3 coyotes. The conclusion: lots of genes have flowed from coyotes and gray wolves into the genomes of the animals that became what we call red and eastern wolves, in different proportions.

A bit of background.

Classifying these animals based on geography and visible traits gets confusing, with all the overlaps and shared DNA sequences. Apparently various pairings can successfully mate but probably don't do so very much in the wild when populations are large. Tracking genomes reveals a classic cline, in the parlance of population genetics, with coyote gene introgression into wolf genomes rising from Alaska and Yellowstone (8-8.5%), to the Great Lakes (21.7-23.9%), to Ontario (32.5%-35.5%), and to Quebec (>50%). (BTW the Basenji, the barkless dog, is 61% gray wolf.)

Paul A. Hohenlohe of the University of Idaho and colleagues maintain that the 2016 findings actually support 2 hypotheses: recent admixture (hybridization) or that red and eastern wolves are distinct species. Actually it's 3: hybridization might have happened a long time ago, something that following genes with known mutation rates might reveal.

The new paper challenges the 28-genome comparison:

Dr. vonHoldt's team responded to Dr. Hohenlohe's team's comments, reiterating that the results show red wolf and eastern wolves are "genetically very similar to coyotes or gray wolves," reflecting recent hybridization.

Discussion of wolf classification goes back a quarter century, and this trio of papers is only a recent glimpse of the debate. But I love the respectful back-and-forth of the efforts to extract a compelling narrative from the data that might be what actually happened. Multiple interpretations of the same data and amending interpretations as new data accumulate is the very essence of the scientific process.

Anti-science rhetoric

Let's reframe the wolf papers using the language of the popular climate change discussion.

Are Hohenlohe and his co-workers "coyote deniers?"

Do vonHoldt and her colleagues "believe in" wolf-coyote couplings and Hohenlohe et al don't?

The science of wolf origins is clearly not "settled" for science is NEVER settled. Facts aren't proven, but instead evidence demonstrated and assessed, from both experimentation and observation. The information from tested hypotheses may be so consistent and compelling that it eventually builds to gestate a theory, or even a law, that then explains further observations. But to get there, science is all about asking questions. As I've written in all 35 or so editions of my various textbooks, science is a cycle of inquiry.

In fact the history of genetics is a chronicle of once-entrenched dogma changing with new experiments and observations. I was in grad school when Walter Gilbert's famed "Why Genes in Pieces?" was published. The classic paper introduced introns, the parts of genes that aren't represented in the encoded protein. It was an astonishing idea circa 1978, but with compelling evidence. Yet even Mendel's pea crosses sought an alternate explanation for the prevailing notion that traits simply disappear between generations.

Before I'm hurled insults, let me assert that although my expertise isn't in climate science, I think that the evidence very strongly supports the hypothesis that the planet is warming at an accelerated rate compared to some other times. And fossil fuel use is likely a partial cause, not just a correlation or association, because the relationship is linear and a mechanism plausible. But I don't "believe" in global warming as if it is the tooth fairy or a deity.

I cringe when politicians and celebrities appoint and anoint themselves experts on climate change, then use language that illustrates profound unfamiliarity with the ways of science.

Why did Eddie Vedder begin his speech at the Rock and Roll Hall of Fame induction ceremony for Pearl Jam with "climate change is real?" He's a musician, not a meteorologist. Why not, "semi-conservative DNA replication is real?" Or "hydrogen bonds are real?" "Noble gases are real?"

I've long had a problem with the term "climate change," because of course climate changes! Why would it ever be static, given weather ups and downs?

Climate dynamics are a little like the composition of blood, or any other manifestation of biological homeostasis. Have a complete blood count at various times and, if you're healthy, results are likely to be within a narrow normal range. Ditto blood sugar, liver enzymes, serum cholesterol level. But steady blood counts don't mean that the same blood cells hang out forever. Bone marrow stem cells continually pump out blood cell progenitors as the older specialized cells die off. Natural systems change over time, with fluctuations large and small.

Climate always has and always will change.

We can learn about normal blood circulation by studying off-kilter situationsleukemia, infection, anemiawithout fear of being labeled a "denier." It's not only a scientifically inappropriate term, but one that is offensive to some, with its echoes of the Holocaust.

I'm interested in other times deep, geologic time, not the president's simplistic reference to the next century when the climate warmed at the rate that it is doing so now. How long did the warming escalate and persist? What forces or events might have precipitated warming? What factors accompanied its ultimate reversal as ice ages neared? By asking questions we can learn what we can expect from nature, so that perhaps we can better understand what we can do to counter the warming trend.

And so those who claim to believe in climate change and vilify those who ask questions might learn a lesson in what science actually is from the elegant discussion of wolf origins.

Explore further: Study doesn't support theory red and eastern wolves are recent hybrids, researchers argue

This story is republished courtesy of PLOS Blogs: blogs.plos.org.

A team led by University of Idaho researchers is calling into question a widely publicized 2016 study that concluded eastern and red wolves are not distinct species, but rather recent hybrids of gray wolves and coyotes. In ...

Research by UCLA biologists published today in the journal Science Advances presents strong evidence that the scientific reason advanced by the U.S. Fish and Wildlife Service to remove the gray wolf from protection under ...

Scientists have successfully produced hybrid pups between a male western gray wolf and a female western coyote in captivity.

Today's Great Lakes gray wolf, de-listed by U.S. officials as an endangered species, probably is a hybrid and no longer the historic animal, biologists said.

Wolves and other top predators need large ranges to be able to control smaller predators whose populations have expanded to the detriment of a balanced ecosystem.

Wolves in the eastern United States are hybrids of gray wolves and coyotes, while the region's coyotes actually are wolf-coyote-dog hybrids, according to a new genetic study that is adding fuel to a longstanding debate over ...

(Phys.org)A group of scientists from several institutions in Germany has suggested that extinct animals that are resurrected through scientific means be given a tag on their name to indicate their origins. In a Policy ...

Flatworms that spent five weeks aboard the International Space Station are helping researchers led by Tufts University scientists to study how an absence of normal gravity and geomagnetic fields can have anatomical, behavioral, ...

The diverse 'coats' which protect a deadly microbe from our immune cells are generated by a 'hotspot' of rapidly evolving genes, a study has found.

It's well known that young babies are more interested in faces than other objects. Now, researchers reporting in Current Biology on June 8 have the first evidence that this preference for faces develops in the womb. By projecting ...

Sex-changing fish exhibit differences in androgen receptor (AR) expression in muscles that are highly sensitive to androgens (male sex hormones) and essential for male courtship behavior, according to a Georgia State University ...

(Phys.org)A small team of researchers from Austria and Sweden has found that ravens are able to remember people who trick them for at least two months. In their paper published in the journal Animal Behavior, the group ...

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North Forsyth grad plans to study biotechnology – Winston-Salem Journal

Posted: June 9, 2017 at 9:46 am

As if the stress of senior year isnt enough of a headache, Michael Vega began his final chapter of high school with a serious concussion.

A soccer injury in May 2016 had mandated three months recovery time, stealing a summer of soccer training from the North Forsyth graduate.

It hit me hard that I couldnt play, coming in with a big concussion, said Vega, a two-time all-conference award recipient. I had to jump right back into it.

Vega, 17, was cleared to play in the final round of the Forsyth Cup last year, helping his team secure a victory in the championship round for the second year in a row, making school history.

Vega, who spent three years on the varsity team, said one of his favorite high school moments was scoring the conference-winning goal against Asheboro High School as a sophomore.

It was a great experience; theres nothing like it, said Vega, who plays goalie and center back. I knew half the guys from growing up, so its hard to say good-bye.

While Vega said he will not play soccer in college, he will continue playing with the Hispanic League.

Graduation is bittersweet, but Vega said he is glad to have AP Biology and AP Chemistry behind him and is applying to Forsyth Tech to study biotechnology.

Ive learned to surround myself with the right people and never give up, Vega said. Im excited for graduation.

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USA Directory of Biotechnology Companies 2017 – Research and Markets – Business Wire (press release)

Posted: June 9, 2017 at 9:46 am

DUBLIN--(BUSINESS WIRE)--Research and Markets has announced the addition of the "USA Directory of Biotechnology Companies 2017" directory to their offering.

The new USA Directory of Biotechnology Companies is one of the most comprehensive and accurate Directory of companies and executives in the biotechnology industry that have ever been published. It contains more than 2,000 biotechnology companies and 5,000 executives working in the industry throughout the USA.

This powerful Directory is your connection to key decision-makers in the biotechnology industry throughout the USA.

No other directory keeps you abreast of the thousands of personnel changes taking place due to company mergers, acquisitions, consolidations, and staff turnover. This Directory is a must-have for anyone who needs to find contacts in the biotechnology throughout the USA.

This Directory will enable you to:

- Pinpoint key executives

- Profile a market

- Build new business prospects

- Generate new customers

- Discover who your competitors are

- Make vital contacts

- Save the time, money and effort of doing your own research

- Identify alternative suppliers and manufacturers

- Source up-to-date company information

- Keep track of key staff movements

- Access a wealth of quality information on companies and key personnel worldwide.

Company categories in this Directory include:

- Biotechnology

- Genomics

- Biopharmaceuticals

- Gene Mapping

- Bioinformatics

- Gene Sequencing

- Biochips

- Pharmacogenomics & SNP's

- Functional Genomics

- plus many more categories!

This Directory also covers senior personnel in key job function areas such as:

- Managing Directors/CEOs

- Strategy & Planning

- Directors

- Market Research

- Senior Management

- Regulatory & Legal Affairs

- Sales & Marketing

- Personnel

- Research & Development

- and much more!

- Business Development

Key Features of the Directory include:

- 2,000 biotechnology companies listed with description of company activities

- 5,000 senior biotechnology personnel listed with name & job title

- Full contact details including email and website addresses

- Global coverage of companies and key personnel

- Comprehensive Indexing.

For more information about this directory visit http://www.researchandmarkets.com/research/3tgbbp/usa_directory_of

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USA Directory of Biotechnology Companies 2017 - Research and Markets - Business Wire (press release)

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Cell Medicine~Cognizant Communication Corporation

Posted: June 9, 2017 at 9:46 am

Future issues are now being published by SAGE. Please visit their website for new issues.

(Scroll down to view tables of contents for all Volumes and Issues)

Volume 9, Number 1 JSOPMB Issue

Facilitating Transplantation 1 Hirofumi Noguchi

Cell Therapy for Liver Disease Using Bioimaging Rats 3 JunkoHaga, ShinEnosawa, andEiji Kobayashi

Challenges for Production of Human Transplantable Organ Grafts 9 Eiji Kobayashi

Evaluation of Serum-Free,Xeno-Free Cryopreservation Solutions for Human Adipose-Derived Mesenchymal Stem Cells 15 Chika Miyagi-Shiohira,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice 21 Yasuma Yoshizumi, Hiroshi Yukawa,Ryoji Iwaki,Sanae Fujinaka,Ayano Kanou, YukiKanou, Tatsuya Yamada, Shingo Nakagawa, TomomiOhara, KentaNakagiri, YusukeOgihara, YokoTsutsui,Yumi Hayashi, MasatoshiIshigami,Yoshinobu Baba, and Tetsuya Ishikawa

EnhancedAdipogenic Differentiation of Human Adipose-Derived Stem Cells in an In Vitro Microenvironment: The Preparation of Adipose-Like Microtissues Using a Three-Dimensional Culture 35 Yoshitaka Miyamoto, MasashiIkeuchi, Hirofumi Noguchi,Tohru Yagi, and Shuji Hayashi

The Evaluation of Islet Purification Methods That Use Large Bottles to Create a Continuous Density Gradient 45 Chika Miyagi-Shiohira,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Comparison of Purification Solutions With Different Osmolality for Porcine Islet Purification 53 Chika Miyagi-Shiohira,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Measurement of DNA Length Changes UponCpG Hypermethylation by Microfluidic Molecular Stretching 61 DaisukeOnoshima, NaokoKawakita, Daiki Takeshita,Hirohiko Niioka, Hiroshi Yukawa, Jun Miyake, andYoshinobu Baba

Volume 8, Number 3

Allogeneic Mesenchymal Stem Cell Transplantation in Dogs WithKeratoconjunctivitis Sicca 63 Maura K. W.Bittencourt, Michele A. Barros, JooFlvio P. Martins, Jose Paulo C.Vasconcellos, Bruna P.Morais, CelinePompeia, MatheusDomingues Bittencourt,Karine dos SantosEvangelho, IrinaKerkis, andCristiane V.Wenceslau

SMA Expression in Large Colonies of Colony-Forming Units-Fibroblast as an Early Predictor of Bone Marrow MSC Expandability 79 IrinaAizman, William S. Holland, Cher Yang, and Damien Bates

Stability Enhancement Using Hyaluronic Acid Gels for Delivery of Human Fetal Progenitor Tenocytes 87 A.Grognuz, C.Scaletta, A.Farron, D. P.Pioletti, W.Raffoul, and L. A. Applegate

Aggregation of Engineered Human -Cells IntoPseudoislets: Insulin Secretion and Gene Expression Profile inNormoxic and Hypoxic Milieu 99 Marie-JosLecomte,Sverine Pechberty, Ccile Machado, Sandra DaBarroca, PhilippeRavassard, RaphalScharfmann, PaulCzernichow, and BertrandDuvilli

Volume 8, Numbers 12 JSOPMB Issue

Creating a Future of Transplantation 1 Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue

Review Cryopreservation of Adipose-Derived Mesenchymal Stem Cells 3 Chika Miyagi-Shiohira, KiyotoKurima,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, Masayuki Matsushita, and Hirofumi Noguchi

Choice of Feeders Is Important When First EstablishingiPSCs Derived From Primarily Cultured Human Deciduous Tooth Dental Pulp Cells 9Issei Saitoh, Emi Inada, Yoko Iwase, Hirofumi Noguchi,Tomoya Murakami, Miki Soda, Naoko Kubota, Hiroko Hasegawa,Eri Akasaka, Yuko Matsumoto, Kyoko Oka,Youichi Yamasaki, HaruakiHayasaki, Masahiro Sato

Review Islet Culture/Preservation Before Islet Transplantation 25 Hirofumi Noguchi, Chika Miyagi-Shiohira, KiyotoKurima,Naoya Kobayashi,Issei Saitoh, Masami Watanabe,Yasufumi Noguchi, and Masayuki Matsushita

Efficient Gene Transduction of Dispersed Islet Cells in Culture Using Fiber-Modified Adenoviral Vectors 31HiroyukiHanayama, KazuoOhashi,Rie Utoh, Hirofumi Shimizu, KazuyaIse,Fuminori Sakurai, Hiroyuki Mizuguchi, Hiroyuki Tsuchiya,Teruo Okano, andMitsukazu Gotoh

Human Laminin Isotype Coating for Creating Islet Cell Sheets 39Shingo Yamashita, KazuoOhashi,Rie Utoh,Teruo Okano, and Masakazu Yamamoto

Spheroid Formation and Evaluation of Hepatic Cells in a Three-Dimensional Culture Device 47Yoshitaka Miyamoto, MasashiIkeuchi, Hirofumi Noguchi,Tohru Yagi, and Shuji Hayashi

Fluorescence Quenching ofCdSe/ZnS Quantum Dots by Using Black Hole Quencher Molecules Intermediated With Peptide forBiosensing Application 57Sreenadh Sasidharan Pillai, Hiroshi Yukawa, DaisukeOnoshima,Vasudevanpillai Biju, andYoshinobu Baba

Volume 7, Number 3

Immature Dental Pulp Stem Cells ShowedRenotropicandPericyte-Like Properties in Acute Renal Failure in Rats 95 Michele A. Barros, Joao FlavioPanattoniMartins,DurvaneiAugusto Maria,CrisitianeValverdeWenceslau,DenerMadeiroDe Souza, AlexandreKerkis, Niels Olsen S.Camara, Julio Cesar C.Balieiro, and IrinaKerkis

A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium 109

Micha Sam BrickmanRaredon,MahboobeGhaedi, Elizabeth A.Calle, and Laura E.Niklason

A Combination of Low-Intensity Pulsed Ultrasound andNanohydroxyapatiteConcordantly Enhances Osteogenesis of Adipose-Derived Stem Cells From Buccal Fat Pad 123 Rika Nagasaki,YoshikiMukudai,YasumasaYoshizawa, Masahiro Nagasaki,SunaoShiogama, Maiko Suzuki, Seiji Kondo, SatoruShintani, and Tatsuo Shirota

Review

Disease and Stem Cell-Based Analysis of the 2014 ASNTR Meeting 133 David J. Eve

Volume 7, Number 2

JSOPMB Issue

Basic and Clinical Science for Organ Biology

Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue

Synergistic Effects ofCalcineurinInhibitors and Steroids on Steroid Sensitivity of Peripheral Blood Mononuclear Cells Hironori Takeuchi, Hitoshi Iwamoto, Yuki Nakamura, Toshihiko Hirano, Osamu Konno, YuKihara,NaokazuChiba, Takayoshi Yokoyama,KiminoriTakano,TatsunoriToraishi, KiyoshiOkuyama, Chie Ikeda, Sachiko Tanaka, KenjiOnda, Akiko Soga, Yukiko Kikuchi, Takashi Kawaguchi, ShigeyukiKawachi, SakaeUnezaki, andMotohideShimazu

Improvement of Infusion Process in Cell Transplantation: Effect of Shear Stress on Hepatocyte Viability Under Horizontal and Vertical Syringe Orientation

SandiSufiandi,HiromichiObara, ShinEnosawa,Huai-CheHsu, NaotoMatsuno, and HiroshiMizunuma

Three-Dimensional In Vitro Hepatic Constructs Formed Using Combinatorial Tapered Stencil for Cluster Culture (TASCL) Device

Yoshitaka Miyamoto, MasashiIkeuchi, Hirofumi Noguchi,TohruYagi, andShujiHayashi

Influence ofAutofluorescenceDerived From Living Body on In Vivo Fluorescence Imaging Using Quantum Dots

Hiroshi Yukawa, Masaki Watanabe,NoritadaKaji, andYoshinobuBaba

Potential Factors for the Differentiation of ESCs/iPSCsInto Insulin-Producing Cells

TakakoTsugata,NaruoNikoh, Tatsuya Kin,IsseiSaitoh,YasufumiNoguchi, Hideo Ueki, Masami Watanabe, Andrew M. James Shapiro, and Hirofumi Noguchi

Volume 7, Number 1

Review

Application of InducedPluripotent Stem Cells in Liver Diseases 1Yue Yu, Xuehao Wang, and Scott L. Nyberg

Original Contribution

Integration-Free Human InducedPluripotent Stem Cells From Type 1 Diabetes Patient Skin Fibroblasts Show Increased Abundance of Pancreas-SpecificmicroRNAs 15 Jun Liu, Mugdha V. Joglekar, Huseyin Sumer, Anandwardhan A. Hardikar, Halena Teede, and Paul J. Verma

Human Menstrual Blood-DerivedMesenchymal Cells as New Human Feeder Layer System for Human Embryonic Stem Cells 25Danubia Silva dos Santos, Vanessa Carvalho Coelho de Oliveira, Karina Dutra Asensi, Leandro Vairo, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho, and Regina Coeli dos Santos Goldenberg

Preculturing Islets With Adipose-DerivedMesenchymal Stromal Cells Is an Effective Strategy for Improving Transplantation Efficiency at the Clinically PreferredIntraportal SiteChloe L. Rackham, Paramjeet K. Dhadda, Aurelie M. Le Lay, Aileen J. F. King, and Peter M. Jones

Volume 6, Number 3

Original Contribution

Autologous Skeletal Myoblast Sheet Therapy for Porcine Myocardial Infarction Without Increasing Risk of Arrhythmia Yutaka Terajima, Tatsuya Shimizu, Shinpei Tsuruyama, Hidekazu Sekine, Hikaru Ishii, Kenji Yamazaki, Nobuhisa Hagiwara, and Teruo Okano

Reviews

Estrogen Replacement Therapy for Stroke Mibel Pabon, Cyrus Tamboli, Sarosh Tamboli, Sandra Acosta, Ike De La Pena, Paul R. Sanberg, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan

Oligodendrocytes Engineered With Migratory Proteins as Effective Graft Source for Cell Transplantation in Multiple Sclerosis Ike De La Pena, Mibel Pabon, Sandra Acosta, Paul R. Sanberg, Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan

Disease and Stem Cell-Based Analysis of the 2013 ASNTR Meeting David J. Eve

Volume 6, Numbers 12

Organ BiologyNew Development Hirofumi Noguchi, Guest Editor in Chief, JSOPMB Issue

Comparison of New Preservation Solutions, HN-1 and University of Wisconsin Solution, in Pancreas Preservation for Porcine Islet Isolation Akihiro Katayama, Hirofumi Noguchi, Takashi Kuise, Atsuko Nakatsuka, Daisho Hirota, Hitomi Usui Kataoka, Takashi Kawai, Kentaro Inoue, Noriko Imagawa, Issei Saitoh, Yasufumi Noguchi, Masami Watanabe, Jun Wada, and Toshiyoshi Fujiwara

Comparison of Incubation Solutions Prior to the Purification of Porcine Islet Cells Takashi Kawai, Hirofumi Noguchi, Takashi Kuise, Atsuko Nakatsuka, Akihiro Katayama, Noriko Imagawa, Hitomi Usui Kataoka, Issei Saitoh, Yasufumi Noguchi, Masami Watanabe, and Toshiyoshi Fujiwara

Maintenance of Viability and Function of Rat Islets With the Use of ROCK Inhibitor Y-27632 Yasuhiro Kubota, Hirofumi Noguchi, Masayuki Seita, Takeshi Yuasa, Hiromi Sasamoto, Shuhei Nakaji, Teru Okitsu, Toshiyoshi Fujiwara, and Naoya Kobayashi

Development of Canine Models of Type 1 Diabetes With Partial Pancreatectomy and the Administration of Streptozotocin Masayuki Seita, Hirofumi Noguchi, Yasuhiro Kubota, Hironobu Kawamoto, Shuhei Nakaji, Naoya Kobayashi, and Toshiyoshi Fujiwara

Quality of Air-Transported Human Islets for Single Islet Cell Preparations Shingo Yamashita, Kazuo Ohashi, Rie Utoh, Tatsuya Kin, A. M. James Shapiro, Masakazu Yamamoto, Mitsukazu Gotoh, and Teruo Okano

Comparison of the Pharmacological Efficacies of Immunosuppressive Drugs Evaluated by the ATP Production and Mitochondrial Activity in Human Lymphocytes Hiroyasu Sasahara, Kentaro Sugiyama, Mahoto Tsukaguchi, Kazuya Isogai, Akira Toyama, Hiroshi Satoh, Kazuhide Saitoh, Yuki Nakagawa, Kota Takahashi, Sachiko Tanaka, Kenji Onda, and Toshihiko Hirano

Peripheral Lymphocyte Response to Mycophenolic Acid In Vitro and Incidence of Cytomegalovirus Infection in Renal Transplantation Kentaro Sugiyama, Hiroyasu Sasahara, Mahoto Tsukaguchi, Kazuya Isogai, Akira Toyama, Hiroshi Satoh, Kazuhide Saitoh, Yuki Nakagawa, Kota Takahashi, Sachiko Tanaka, Kenji Onda, and Toshihiko Hirano

Experimental Nonalcoholic Steatohepatitis Induced by Neonatal Streptozotocin Injection and a High-Fat Diet in Rats Huai-Che Hsu, Masaharu Dozen, Naoto Matsuno, Hiromichi Obara, Ryou Tanaka, and Shin Enosawa

Electron Therapy Attenuated Elevated Alanine Aminotransferase and Oxidative Stress Values in Type 2 Diabetes-Induced Nonalcoholic Steatohepatitis of Rats Shin Enosawa, Masaharu Dozen, Yuki Tada, and Keisuke Hirasawa

STO Feeder Cells Are Useful for Propagation of Primarily Cultured Human Deciduous Dental Pulp Cells by Eliminating Contaminating Bacteria and Promoting Cellular Outgrowth Tomoya Murakami, Issei Saitoh, Emi Inada, Mie Kurosawa, Yoko Iwase, Hirofumi Noguchi, Yutaka Terao, Youichi Yamasaki, Haruaki Hayasaki, and Masahiro Sato

Induced Pluripotent Stem Cell Labeling Using Quantum Dots Hiroshi Yukawa, Kaoru Suzuki, Yuki Kano, Tatsuya Yamada, Noritada Kaji, Tetsuya Ishikawa, and Yoshinobu Baba

Adipose Tissue-Derived Stem Cell Imaging Using Cadmium-Free Quantum Dots Yoshiyuki Miyazaki, Hiroshi Yukawa, Hiroyasu Nishi, Yukihiro Okamoto, Noritada Kaji, Tsukasa Torimoto, and Yoshinobu Baba

Volume 5, Numbers 2-3 Japan Society for Organ Preservation and Medical Biology (JSOPMB) Long-Expected New Start Hirofumi Noguchi, Guest Editor-in-Chief, JSOPMB Issue Reviews

Bioimaging of Transgenic Rats Established at Jichi Medical University: Applications in Transplantation Research Takumi Teratani and Eiji Kobayashi

ER Stress and b-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation Hitomi Usui Kataoka and Hirofumi Noguchi

A Review of Autologous Islet Transplantation Michihiro Maruyama, Takashi Kenmochi, Naotake Akutsu, Kazunori Otsuki, Taihei Ito, Ikuko Matsumoto, and Takehide Asano

Original Contributions Culture Conditions for Mouse Pancreatic Stem Cells Hirofumi Noguchi, Issei Saitoh, Hitomi Usui Kataoka, Masami Watanabe, Yasufumi Noguchi, and Toshiyoshi Fujiwara

Isolation Efficiency of Mouse Pancreatic Stem Cells Is Age Dependent Takashi Kuise, Hirofumi Noguchi, Issei Saitoh, Hitomi Usui Kataoka, Masami Watanabe, Yasufumi Noguchi, and Toshiyoshi Fujiwara

Use of Mesenchymal Stem Cell-Conditioned Medium to Activate Islets in Preservation Solution Naoya Kasahara, Takumi Teratani, Junshi Doi, Yuki Iijima, Masashi Maeda, Shinji Uemoto, Yasuhiro Fujimoto, Naohiro Sata, Yoshikazu Yasuda, and Eiji Kobayashi

Inhibition of Hepatic Ischemic Reperfusion Injury Using Saline Exposed to Electron Discharge in a Rat Model Masaharu Dozen, Shin Enosawa, Yuki Tada, and Keisuke Hirasawa

Observation of Positively Charged Magnetic Nanoparticles Inside HepG2 Spheroids Using Electron Microscopy Yoshitaka Miyamoto, Yumie Koshidaka, Hirofumi Noguchi, Koichi Oishi, Hiroaki Saito, Hiroshi Yukawa, Noritada Kaji, Takeshi Ikeya, Satoshi Suzuki, Hisashi Iwata, Yoshinobu Baba, Katsutoshi Murase, and Shuji Hayashi

Improved Recovery of Hepatocytes Isolated From Warm Ischemic Rat Liver by Citrate Phosphate Dextrose (CPD)-Supplemented Euro-Collins Solution Huai-Che Hsu, Naoto Matsuno, Noboru Machida, and Shin Enosawa

Volume 5, Number 1

ReviewHuman Liver Progenitor Cells for Liver Repair Catherine A. Lombard, Julie Prigent, and Etienne M. Sokal

Original Contributions

Transplantation of Human Adipose Tissue-Derived Mesenchymal Stem Cells Restores the Neurobehavioral Disorders of Rats With Neonatal Hypoxic-Ischemic Encephalopathy Dongsun Park, Sun Hee Lee, Dae Kwon Bae, Yun-Hui Yang, Goeun Yang, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Jin Tae Hong, Il Seob Shin, Sung Keun Kang, Jeong Chan Ra, and Yun-Bae Kim

Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells Wanja Wolber, Ruhel Ahmad, Soon Won Choi, Sigrid Eckardt, K. John McLaughlin, Jessica Schmitt, Christian Geis, Manfred Heckmann, Anna-Leena Siren, and Albrecht M. Muller

Volume 4, Number 3

Simple Machine Perfusion Significantly Enhances Hepatocyte Yields of Ischemic and Fresh Rat LiversMaria-Louisa Izamis, Candice Calhoun, Basak E. Uygun, Maria Angela Guzzardi, Gavrielle Price, Martha Luitje, Nima Saeidi, Martin L. Yarmush, and Korkut Uygun

Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem CellsTomoko Shofuda, Daisuke Kanematsu, Hayato Fukusumi, Atsuyo Yamamoto, Yohei Bamba, Sumiko Yoshitatsu, Hiroshi Suemizu, Masato Nakamura, Yoshikazu Sugimoto, Miho Kusuda Furue, Arihiro Kohara, Wado Akamatsu, Yohei Okada, Hideyuki Okano, Mami Yamasaki, and Yonehiro Kanemura

Brief Communication

Cell Persistence of Allogeneic Keratinocytes and Fibroblasts Applied in a Fibrin Matrix to Acute, Full Thickness WoundsJaime E. Dickerson Jr., John V. Planz, Barry T. Reece, Kathy A. Weedon, Sandy D. Kirkpatrick, and Herbert B. Slade

Volume 4, Number 2

Nestin Overexpression Precedes Caspase-3 Upregulation in Rats Exposed to Controlled Cortical Impact Traumatic Brain InjuryYuji Kaneko, Naoki Tajiri, SeongJin Yu, Takuro Hayashi, Christine E. Stahl, Eunkyung Bae, Humberto Mestre, Nicholas Franzese, Antonio Rodrigues Jr., Maria C. Rodrigues, Hiroto Ishikawa, Kazutaka Shinozuka, Whitney Hethorn, Nathan Weinbren, Loren E. Glover, Jun Tan, Anilkumar Harapanahalli Achyuta, Harry van Loveren, Paul R. Sanberg, Sundaram Shivsankar, and Cesar V. Borlongan

The Effect of CXCR4 Overexpression on Mesenchymal Stem Cell Transplantation in Ischemic StrokeOh Young Bang, Kyung Sil Jin, Mi Na Hwang, Ho Young Kang, Byoung Joon Kim, Sang Jin Lee, Sangmee Kang, Yu Kyeong Hwang, Jong Seong Ahn, and Ki Woong Sung

Use of Magnetocapsules for In Vivo Visualization and Enhanced Survival of Xenogeneic HepG2 Cell TransplantsThomas W. Link, Dian R. Arifin, Christopher M. Long, Piotr Walczak, Naser Muja, Aravind Arepally, and Jeff W. M. Bulte

Improved Hepatocyte Engraftment After Portal Vein Occlusion in LDL Receptor-Deficient WHHL Rabbits and Lentiviral-Mediated Phenotypic Correction In VitroSylvie Goulinet-Mainot, Hadrien Tranchart, Marie-Thrse Groyer-Picard, Panagiotis Lainas, Papa Saloum Diop, Delphine Holopherne, Patrick Gonin, Karim Benihoud, Nathalie Ba, Olivier Gauthier, Dominique Franco, Catherine Guettier, Danile Pariente, Anne Weber, Ibrahim Dagher, and Tuan Huy Nguyen

Behavior of Human Articular Chondrocytes During In Vivo Culture in Closed, Permeable ChambersIigo Martinez-Zubiaurre, Tuija Annala, and Martin Polacek

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Abused pup receives cutting-edge stem cell therapy | fox5sandiego … – fox5sandiego.com

Posted: June 9, 2017 at 9:45 am

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SAN DIEGO Abused orphan pup "Dwyane," who has severe disfigurements, is on the road to recovery after stem cell therapy by a Poway-based company.

The one-year-old puppy was reportedly kicked, beaten and forced to wear a wire muzzle before he was rescued in Tijuana.

Last month, he was taken to Helen Woodward Animal Center in Rancho Sante Fe. Since then, the dog has undergone several procedures, including a hip surgery Tuesday.

Animal hospital officials said Dwaynes work isnt over yet, as he still needs major reconstruction to his elbow and additional facial surgeries to help him breathe easier.

There is no risk involved because we use the dog's own tissue to isolate the stem cell, said Dr. Jeffrey Schaffer with VetStem of Poway.

Today, we gave the injection of the stem cells in the hip and then a slow one through the vein," said Dr. Patricia Carter, chief veterinarian at Helen Woodward Animal Center. "Then we gave him something that made him unsleepy, but hes still recovering from the surgery two days ago.

Dwayne is a warrior and shows his love to those who have love to give.

He is adorable, sweet and with everything that is going on, he wants to give you kisses and love, Schaffer said.

Over $40,000 has been donated to Dwayne for medical costs from around the world, including Paris. He also has had plenty of people giving well wishes and dropping off toys at the animal hospital.

The animal center posts updates on Dwayne and other orphan pets on itswebsite.

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Chinese cell therapy effective in small multiple myeloma trial | Reuters – Reuters

Posted: June 9, 2017 at 9:45 am

By Deena Beasley | CHICAGO

CHICAGO A small trial conducted in China found that an experimental therapy using altered cells to recruit the body's immune system to attack cancer can induce remission in most patients with advanced multiple myeloma, a blood plasma cancer.

The study of 35 patients tested a chimeric antigen receptor T-cell (CAR-T) therapy developed by China's Nanjing Legend Biotech Co.

The drug candidate, known as LCAR-B38M, targets a protein called BCMA found on cancerous blood plasma cells - the same target being pursued by Bluebird Bio Inc and Celgene Corp with their CAR-T called bb2121.

CAR-T therapies require a complicated process of extracting immune system T cells from an individual patient, altering their DNA to sharpen their ability to spot and kill cancer cells, and infusing them back into the same patient.

The American Society of Clinical Oncology, which featured the data here at its annual meeting, said that out of 19 trial patients followed for more than four months, 14 reached complete remission. One patient had a partial response and four patients reached "very good partial remission," but the cancer did get worse in one of those patients.

Multiple myeloma "is a disease you can treat pretty well with other drugs, but this could be long-term remission," said Dr. Bruce Johnson, chief clinical research officer at Boston's Dana-Farber Cancer Institute and ASCO's incoming president.

Eighty five percent of trial patients experienced cytokine release syndrome (CRS), a potentially life-threatening inflammatory condition, but researchers said the side effect was temporary and manageable in most patients. Two people had severe CRS, but recovered after treatment with Actemra, an anti-inflammatory drug.

The study is being conducted at Second Affiliated Hospital of Xi'an Jiaotong University in Xi'an, China.

The largest investor in Nanjing Legend Biotech is Genscript Biotech, a multinational provider of contract research services to pharmaceutical companies and others, according to Dr. Frank Fan, chief scientific officer at Nanjing Legend.

He said the company plans to enroll a total of 100 patients in the Chinese trial and to start a similar trial in the United States in early 2018.

"At ASCO I will hope to find collaborators in the U.S.," Fan told Reuters. "We are open for collaboration at different levels."

So far two companies have filed for U.S. approval of CAR-T drugs targeting a different protein called CD19. Kite Pharma Inc expects the Food and Drug Administration to decide by Nov. 29 whether to approve axicabtagene ciloleucel for advanced non-Hodgkin lymphoma, a cancer that starts in white blood cells.

The FDA is also reviewing Novartis AG's tisagenlecleucel-T for pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia.

(Reporting by Deena Beasley; Editing by Phil Berlowitz)

SINGAPORE Singapore on Friday confirmed two cases of locally transmitted infections of the mosquito-borne Zika virus, bringing the total number of reported cases in the city-state this year to eight.

TOKYO Japan has dropped proposals on price cuts for prescription drugs aimed at boosting the use of generic drugs, underscoring the government's struggle to rein in bulging social security costs for a rapidly ageing nation.

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Lexicon 3-for-3 in PhIII for a new diabetes pill, racking up a clean sweep under $1.7B Sanofi pact – Endpoints News

Posted: June 9, 2017 at 9:45 am

Lexicon Pharmaceuticals $LXRX is now three-for-three in its Phase III program for sotagliflozin, setting up regulatory applications for this Sanofi-partnered therapy as the first pill to help Type 1 diabetics with glycemic control. And it positions the Texas biotech for its late-stage effort aimed at proving it can do the same for Type 2 diabetes.

Investigators tested this add-on drug in 1,402 patients with A1C levels between 7% and 11%, with a 400 mg dose beating a placebo in pushing a significant number of patients below the 7 mark the magic number for glycemic control in diabetes. But well have to wait for a scientific conference to get the details from inTandem3.

The important point for now is that Lexicon appears poised to pursue marketing approval for a novel drug that targets both SGLT-1 and SGLT-2. SGLT-2 drugs like Jardiance, Invokana and Farxiga have already made their mark on the market, blocking glucose absorption in the kidneys. But this therapy adds another target in the intestinal tract.

This may not revolutionize therapy, but in diabetes R&D developing drugs for a mass audience of millions around the globe every incremental step forward marks blockbuster potential.

Sanofi saw the promise and came in to bag the worldwide rights to the drug leaving Lexicon with US co-promotion rights with a $300 million upfront payment and $1.4 billion in potential milestones.

This has been a watershed year for Lexicon. Just a few months ago the biotechcompleted a marathon development program with anFDA approvalof telotristatethyl (which will be sold as Xermelo and was formerly known as LX1032) for carcinoid syndrome, which is linked with severe diarrhea.

Lonnel Coats

These positive results represent an important milestone, further supporting sotagliflozins differentiated profile as a novel, oral anti-diabetic agent with potential to benefit people with type 1 diabetes, said Lonnel Coats, Lexicons president and chief executive officer, in a prepared statement. Sotagliflozin is the first-ever oral anti-diabetic drug candidate to have achieved success in now three consecutive Phase III clinical trials in this population.

News reports for those who discover, develop, and market drugs. Join 16,000+ biopharma pros who read Endpoints News articles by email every day. Free subscription.

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Diabetes drugs linked to higher risk for rare but deadly complication … – CBS News

Posted: June 9, 2017 at 9:45 am

A new class of type 2 diabetes drugs called SGLT2 inhibitors could increase the risk of a rare, life-threatening complication of the disease called ketoacidosis, a new study warns.

SGLT2 inhibitors include prescription medications such as canagliflozin, dapagliflozin and empagliflozin. Brand names are Invokana, Invokamet, Farxiga, Xigduo XR, Jardiance and Glyxambi.

These drugs first became available in 2013, but in 2015 the U.S. Food and Drug Administration issued a warning about an increased risk for diabetic ketoacidosis when SGLT2 inhibitors are used.

The condition typically occurs in people with type 1 diabetes. And while it is uncommon in people with type 2 diabetes, case reports have shown it can occur with type 2 disease, according to the study authors.

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Some diabetes patients are begging doctors for free samples of life-saving insulin because of costs. Between 2002 and 2013, the price of insulin ...

Ketoacidosis can cause vomiting, abdominal pain, shortness of breath and swelling in the brain. Left untreated, the condition can be fatal, the researchers said.

The new study "essentially confirms what doctors had already suspected," said diabetes expert Dr. Stanislaw Klek, an endocrinologist at NYU Winthrop Hospital in Mineola, N.Y.

"Fortunately, the rate of diabetic ketoacidosis is still very low and should not prevent the usage of this medication class," he added. "It is important to be aware of this potential complication and monitor for symptoms of diabetic ketoacidosis, particularly during periods of illness."

In the new study, researchers at Brigham and Women's Hospital in Boston analyzed data from 40,000 people with type 2 diabetes. They found that those taking SGLT2 inhibitors were twice as likely to develop diabetic ketoacidosis than those taking another class of diabetes drugs called DPP4 inhibitors (drugs such as Januvia and Onglyza).

Still, the risk to any one patient remains very slim, the researchers stressed. They estimated that among patients taking an SGLT2 inhibitor, only about 1 in every 1,000 patients would develop ketoacidosis.

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A new World Health Organization report says that cases of diabetes have skyrocketed, quadrupling from 108 million worldwide in 1980 to over 420 m...

The findings were published June 8 in theNew England Journal of Medicine.

Even though diabetic ketoacidosis is uncommon, doctors need to closely monitor type 2 diabetes patients for signs and symptoms of the complication, said study author Dr. Michael Fralick. He's from Brigham and Women's division of pharmacoepidemiology and pharmacoeconomics.

"This is a side effect that's usually seen in patients with type 1 diabetes mellitus -- not type 2 -- so doctors are not 'on the lookout' for it," Fralick said in a hospital news release. "That means that the risk of this side effect might actually be even higher than what we found due to misdiagnosis/under-recording."

Dr. Minisha Sood is an endocrinologist at Lenox Hill Hospital in New York City. Reviewing the findings, she explained that SGLT2 inhibitors "have been a welcome addition to the arsenal of glucose [blood sugar]-lowering medications. They lower blood glucose by increasing the amount of glucose eliminated through the urine."

But the drugs may interfere with levels of a particular hormone, glucagon, which in turn leads to an unhealthy rise in acids called ketones. "When ketone acids build up in the system, this can lead to diabetic ketoacidosis," Sood explained.

She agreed that patients and doctors should be alert to the rare but potential risk for diabetic ketoacidosis, especially in the early weeks after a person starts taking an SLGT2 inhibitor.

But Sood believes the study findings are not reason for patients to immediately switch to another form of diabetes medication.

"SLGT2 inhibitors work extremely well to control diabetes [and they have the added benefit of lowering blood pressure and weight as well] so the benefits definitely outweigh the risks of therapy," she said.

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Diabetes drugs linked to higher risk for rare but deadly complication ... - CBS News

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WSU gets $3 million NIH grant for improving diabetes care in youth – Crain’s Detroit Business

Posted: June 9, 2017 at 9:45 am

Wayne State University has received a $3.05 million grant from the National Institute of Health for a five-year trial focused on helping parents and other caretakers assist diabetic adolescents to complete their daily care.

The trial is aimed at African-American young people diagnosed with Type 1 diabetes, because they are considered to be at higher risk for poor diabetes management, according to Wayne State's website.

The five-year trial will study a computer-delivered intervention during doctor visits that reminds and motivates parents to stay involved in their child's care, the university said in a statement. During visits to the clinic, caretakers will be given a tablet on which an avatar will take them through a sort of multimedia course that includes informational video clips, testimonials, motivational content and goal-setting strategies. Test trials have already been conducted and indicate that the intervention is effective.

"Research has shown that maintaining high levels of parental involvement and supervision of daily diabetes care is a critical predictor of youth diabetes management," said Deborah Ellis, Ph.D., professor of family medicine and public health sciences in Wayne State's School of Medicine. "However, physicians do not always have time to discuss parenting behaviors during busy clinic visits."

It will be rolled out in October at the Children's Hospital of Michigan as well as three sites in Chicago, Ellis said. Between 200 and 250 African-American adolescents will be included in this trial.

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