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Cold virus, stem cells tested to destroy deadly brain cancer – Medical Xpress

Posted: May 26, 2017 at 8:42 am

May 25, 2017 by Kristin Samuelson Killer T cells surround a cancer cell. Credit: NIH

A first-of-a-kind neural stem cell therapy that works with a common cold virus to seek out and attack a lethal and aggressive brain cancer is being tested at Northwestern Medicine in a Phase I clinical trial for patients newly diagnosed with malignant glioma.

The novel drug to treat malignant glioma, notorious for recurring after typical bouts of standard cancer treatment, was developed by a Northwestern scientist and has been approved as an investigational drug by the U.S. Food and Drug Administration. This is only the second time the University has supported and filed an investigational new drug as a sponsor.

"We have discovered that combining stem cells with a virus causes the new drug to react like a cancer-seeking missile targeting cancerous cells in the brain" said principal investigator, Dr. Maciej Lesniak, the Michael J. Marchese Professor and chair of neurological surgery at Northwestern University Feinberg School of Medicine and a neuro-oncologist at Northwestern Medicine. "If it works in humans, it could be a powerful weapon against brain cancer and an option that our patients are desperate for."

One reason malignant glioma recurs so often is because a small subpopulation of cancer cells, often deep in the brain tissue, is highly resistant to chemotherapy and radiation.

The pre-clinical work done by Lesniak and his team has shown that the approach being tested at Northwestern Medicine can target this population of therapy resistant cells, further delaying and sometimes even preventing tumor recurrence.

The stem cells used in the research came from a collaboration of researchers from City of Hope.

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"We haven't seen significant progress in the last decade for patients with a brain tumor, and that is why it's crucial to do everything we can to find a better treatment for brain tumors," said Dr. Roger Stupp, a co-investigator who is working alongside Lesniak on this clinical trial. "Combining novel therapy with medical expertise, we are able to get one step closer to eradicating this lethal disease."

Stupp, a world-renowned neuro-oncologist, recently joined Northwestern Medicine as director of neuro-oncology and associate director for strategic initiatives at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. He is best known for developing temozolomide in combination with radiation as the standard-of-care chemotherapy for patients with glioblastoma.

Lesniak and his team of scientists are starting to test the safety and dosage of the treatment in patients at Northwestern Memorial Hospital. Lesniak began the research more than a decade ago while at the University of Chicago and completed it when he moved to Northwestern in 2015.

This investigational new drug contains neural stem cells to deliver a potent virus responsible for the common cold, oncolyotic adenovirus, which is engineered to kill brain cancer cells. The novel treatment works synergistically with chemotherapy and radiation to enhance the standard cancer treatments effectiveness.

Malignant gliomas are the most aggressive forms of cancer and are predicted to affect nearly 20,000 new patients this year, according to the American Brain Tumor Association. Sometimes called the "grow-and-go" tumors, gliomas can make their own blood supply, which fuels the tumors' rapid growth and helps them hatch satellite tumors. Each tumor sends out tentacles that infiltrate and dig deep into normal brain tissue, making complete removal of cancerous cells impossible. Any cancerous cells in the brain left over from standard of care can cause the tumor to recur.

Lesniak plans to enroll up to 36 newly diagnosed patients with glioma. These patients will be divided into two groups: those with tumors that can be removed and those where the tumors are not removable by surgery.

Next step, Northwestern Memorial will extend this research to the collaborating partners at City of Hope Comprehensive Cancer Center in Duarte, California.

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Cold virus, stem cells tested to destroy deadly brain cancer - Medical Xpress

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Bioelectricity new weapon to fight dangerous infection – Medical Xpress

Posted: May 26, 2017 at 8:42 am

May 26, 2017 How Vmem signal strengthens innate immune response: Normal tadpoles have polarized cells, with specific native amounts and distributions of melanocytes (pigment cells) and primitive myeloid cells (part of the innate immune system). Following chemical or genetic treatments that depolarize the cells' Vmem (transmembrane potential, or voltage potential caused by differences in negative and positive ions on opposite sides of a cell's membrane), pathways involving serotonin signaling induce proliferation and redistribution of both melanocytes and primitive myeloid cells, leading to an increase in the efficiency of the immune response when stimulated with a pathogen such as E. coli. Tail amputation induces a strong posterior Vmem depolarization at the site of injury, where melanocytes and primitive myeloid cells are recruited, resulting in a net increase of the latter in the embryo, leading to an enhanced innate immune response. Findings from Tufts University biologists appear in npj Regenerative Medicine on May 26, 2017. Credit: Jean-Francois Pare/Tufts University

Changing the natural electrical signaling that exists in cells outside the nervous system can improve resistance to life-threatening bacterial infections, according to new research from Tufts University biologists. The researchers found that administering drugs, including those already used in humans for other purposes, to make the cell interior more negatively charged strengthens tadpoles' innate immune response to E. coli infection and injury. This reveals a novel aspect of the immune system - regulation by non-neural bioelectricity - and suggests a new approach for clinical applications in human medicine. The study is published online May 26, 2017, in npj Regenerative Medicine, a Nature Research journal.

"All cells, not just nerve cells, naturally generate and receive electrical signals. Being able to regulate such non-neural bioelectricity with the many ion channel and neurotransmitter drugs that are already human-approved gives us an amazing new toolkit to augment the immune system's ability to resist infections," said the paper's corresponding author Michael Levin, Ph.D., Vannevar Bush professor of biology and director of the Allen Discovery Center at Tufts and the Tufts Center for Regenerative and Developmental Biology in the School of Arts and Sciences. Levin is also an associate faculty member of the Wyss Institute of Biologically Inspired Engineering at Harvard University.

All vertebrates, from fish to people, have two kinds of immunity with common features. The adaptive immune system relies on the memory of previous exposure to a specific pathogen and is the basis for current vaccination strategies. The innate immune system is present from the time an egg is fertilized and provides a first line of defense against pathogens through surface barriers, antimicrobial amino acids called peptides, and certain blood cells. The innate immune system also plays a role in tissue repair and regeneration, and the interplay between regeneration and innate immunity is an emerging field of study.

Better understanding of innate immunity can advance efforts to combat new pathogens to which no adaptive memory has developed, address geographic migration of diseases, support immune-deficient patients, and develop more effective treatment of traumatic injuries.

Transmembrane potential (Vmem) - voltage potential caused by differences in negative and positive ions on opposite sides of a cell's membrane - is known to play a critical role in many essential functions in numerous cell types, and the researchers hypothesized that it also could affect innate immunity. In the study, embryonic Xenopus laevis frogs infected with human pathogenic E. coli bacteria were exposed to compounds, including some used in human medicine, to either depolarize (positively charge) or hyperpolarize (negatively charge) their cells. Developing X. laevis frogs are a popular model for regenerative, developmental, cancer and neurobiological studies.

Decreased deaths from pathogenic E. coli

Depolarization with different agents significantly increased the embryos' ability to resist the bacteria. The ratio of embryos that survived infection after receiving ivermectin, a human anti-parasitic, increased on average 32 percent compared with those not receiving the depolarizing compound. Mortality in untreated control embryos was 50 to 70 percent.

To verify that the depolarizing compounds were changing the host cells' electrical charge and not simply harming the bacteria, further experiments were conducted in which tadpole cells were injected with mRNA that encoded (provided the particular genetic language for) specific ion channels that would depolarize the frog cells directly, without affecting the bacteria. This approach validated what was observed with the depolarizing drugs.

In contrast, injecting cells with hyperpolarizing channel-encoding mRNA reduced the ratio of infected embryos that survived by about 20 percent. Similarly, embryo survival was reduced by exposure to chemical compounds that hyperpolarized the embryos or interfered with depolarization.

Experiments also found that the neurotransmitter serotonin is an intermediary between voltage and immune response, a finding consistent with other recent research from the Levin laboratory. The common anti-depressant fluoxetine, which blocks serotonin movement in and out of cell membranes, was shown to negate the beneficial effects of depolarization on embryo survival.

Analysis of the genes whose expression was altered by changing the tadpole cells' bioelectrical state found that the interplay among voltage, neurotransmitter signaling and immune function impacts many of the same genes that are involved in human immune response.

Unexpected finding: Injury boosts immunity

To examine the connection among bioelectrics, immunity and regeneration, the study investigated the effect of tail bud amputation on survival following infection. Surprisingly, removing embryos' tail buds increased their ability to survive E. coli infection. Instead of the added stress of tail regeneration overwhelming the embryo, the injury and the infection induced common defense mechanisms, including recruiting macrophages (a type of white blood cell that is part of the innate immune system), which appeared to increase efficiency in eliminating the bacteria.

"Components of the innate immune system such as macrophages were known to be essential to the process of regeneration, but the new study examines the opposite and equally important side of that relationship - how regeneration impacts the immune system," said Jean-Francois Pare, Ph.D., first author on the paper and a research associate in the Levin laboratory. "The interplay between response to physical injuries and infection has the potential to reveal new ways of treating both infections and severe physical injuries."

Joining Pare and Levin in authorship of the paper was Christopher J. Martyniuk of the Center for Environmental and Human Toxicology and Department of Physiological Sciences, University of Florida Genetics Institute, College of Veterinary Medicine, University of Florida, Gainesville.

Studies to extend this research to mammalian systems are now underway at Tufts University and the Wyss Institute. Further research is also needed to determine precisely which cells sense the bioelectric changes and transmit the effect to the innate immune cells involved, how infectious bacteria themselves may respond to changes in the bioelectric microenvironment, and the role of the internal microbiome in these interactions.

Explore further: Drosophila innate immunity: Another piece to the puzzle

More information: Jean-Franois Par et al, Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis, npj Regenerative Medicine (2017). DOI: 10.1038/s41536-017-0019-y

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Summer pregnancy may raise gestational diabetes risk – CNN

Posted: May 26, 2017 at 8:40 am

Gestational diabetes can also raise babies' risks of excessive birth weight, preterm birth, and type 2 diabetes later in life.

For this reason, it's been suggested that cold temperatures might protect against these conditions.

To study this potential connection in pregnant women, researchers looked at medical records of nearly 400,000 women living in the same urban area in Canada, in a region with wide temperature fluctuations throughout the year. Over a 12-year period, those women gave birth to more than 555,000 children.

When the researchers looked at average temperatures in the 30 days before these women gave birth, they found that the prevalence of gestational diabetes was 4.6% among those exposed to very cold temperatures (14 degrees Fahrenheit or lower), compared to 7.7% among those exposed to very hot temperatures (75 degrees Fahrenheit or higher).

That translates to a 6% to 9% relative increase in the risk of gestational diabetes for every increase of about 18 degrees Fahrenheit (or every 10 degrees Celsius), the researchers calculated.

The relationship held true even when the researchers compared two consecutive pregnancies in the same woman, which allowed them to cancel out factors such as income, ethnicity, and lifestyle habits that could also affect risk.

This may seem counterintuitive, says lead author Gillian Booth, MD, a researcher at St. Michael's Hospital and the Institute for Clinical Evaluative Sciences in Toronto, since people might think that pregnant women would spend more time outdoors and be more active during warmer months. But the findings fit a pattern of recent research on the potential protective effects of colder temperatures, she says.

And although the researchers only looked at a single geographic region in Canada, they say the results could likely apply to other parts of North American and the world.

"Based on the study's findings we would expect pregnancies in warmer climates to be at higher risk of gestational diabetes, although we weren't able to look at that directly," Dr. Booth told Health. "I think that's a great topic for future research."

The study also suggests that gestational diabetes -- and adult-onset diabetes, which shares the same risk factors -- could become increasingly prevalent worldwide as global temperatures continue to increase.

Because the study was not a randomized trial, it was unable to show a cause-and-effect relationship. The study also did not include information about body mass index, weight gain, physical activity, or diet of the women involved. But it does "offer fairly compelling evidence that air temperature may be a modifiable risk factor for gestational diabetes," says Dr. Booth.

Strategies like using air conditioning and avoiding excess layers in the summer might influence a pregnant woman's risk of gestational diabetes, says Dr. Booth.

These may be especially important for women who have strong non-modifiable risk factors for gestational diabetes, she adds, including non-European ethnicity, family history of type 2 diabetes, or a prior pregnancy with gestational diabetes.

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Temperature appears to have a smaller effect on gestational diabetes than these other risk factors, but "it is one factor that might be sufficient to push someone's risk over the edge," says Dr. Booth.

And while the number of women impacted globally by temperature fluctuations may be substantial, she says, the increased risk for individual women is likely small.

Staying cool during hot weather is probably a smart idea, says Dr. Booth, but women can also protect themselves from gestational diabetes by following strategies that have been proven to lower their risk -- like achieving a healthier body weight before they conceive, and avoiding excess weight gain during pregnancy by consuming a healthy diet and being physically active.

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Gaston 5-year-old lobbying Congress for Type 1 diabetes cure – Gaston Gazette

Posted: May 26, 2017 at 8:40 am

Eric Wildstein Gazette staff TheGazetteEric

Hes only 5 years old, but hes preparing to advocate for juvenile diabetes research before Congress.

Miles Bone spent Wednesday morning engaged in a wild, water war with his pre-kindergarten classmates at Gaston Day School to celebrate the end of the year. After toweling off, he readied to eat a chicken nuggets lunch from Chick-fil-A with everyone.

But first, he had to prick his finger with a needle to test his blood glucose level, a ritual he must repeat several times each day as a Type 1 diabetic. He entered his glucose number into an insulin pumpwhich he wears basically 24/7that injects him with the correct amount of insulin through a tube attached to his arm to keep his blood glucose stable after eating.

We talked about last night how he wants to show people what its like to have Type 1 diabetes because a lot of people dont know, said Sara Bone, Miless mother. A lot of people dont understand what Type 1 diabetes is and how much it affects his life and how hard he has to work to take care of himself.

Type 1 diabetes, also known as juvenile diabetes, is an autoimmune disease in which a persons pancreas stops producing insulin, a hormone people need to get energy from food. Children and adults can be diagnosed suddenly at any age. It cannot be prevented and there is no cure.

Miles, who lives in Dallas with his parents and older brother, will advocate for Type 1 diabetes research on Capitol Hill in late July. He applied and was selected to be part of a delegation of about 160 children from each U.S. state and several countries representing the Juvenile Diabetes Research Foundation 2017 Childrens Congress, a bi-annual event.

The delegates will be lobbying their representatives of Congress to remind them of the vital need to continue supporting Type 1 diabetes research that could reduce the burden of the disease and ultimately find a cure.

CC 2015 Highlights from JDRF on Vimeo.

These childrenages 4 to 17will participate in a number of activities on the Hill, including a Congressional Committee hearing to share personal testimonies that highlight the daily struggles of living with Type 1 diabetes and the need for continued funding for research projects such as the Special Diabetes Program, which provides $150 million annually for Type 1 diabetes research at the National Institutes of Health.

I want Miles to one day be able to eat some pizza and not feel bad three hours later for doing it, said Sara Bone. I think that were almost there and I want him to actually know a day where he doesnt have to worry about it.

Miles was diagnosed with Type 1 diabetes just three days after his first birthday. His parents noticed he was feeling ill and scheduled a visit with his pediatrician. Miles was hospitalized with diabetic ketoacidosis, a potentially-deadly result of extremely high blood glucose and remained there for three days before his release. It was a scary time for his parents and brother, who had no family history of Type 1 diabetes and were new to caring for the condition.

It was the scariest thing that first day we brought him home, said Sara Bone. You just think how am I ever going to do this.

They would learn to balance the high and low blood glucose fluctuations that result from diabetes and how to maintain them with a proper diet. That includes keeping a close eye on what Miles eats, delivering insulin at the proper times and boosting low blood glucose with juice boxes, glucose tablets or another form of carbohydrate.

At school, Miless teachers help him to keep track of his health, though hes already handling a lot of the heavy lifting on his own. Sara Bone says its a constant balancing act and it causes Miles to miss out on or delay certain activities so that he can care for his diabetes. But she feels its already made him a stronger person.

Its made him more compassionate, she said. Its made his brother a compassionate kid. He really cares about Miles and wants to see him OK and cares about his future.

And Miles will work toward that brighter future by joining a long list of other advocates with Type 1 diabetes, such as celebrities including the NHL Hall of Fame hockey player Bobby Clarke, musicians Bret Michaels and Nick Jonas, and the late actress Mary Tyler Moore.

NASCAR Xfinity series driver Ryan Reed, 23, was diagnosed with Type 1 diabetes in 2011. He later began his nonprofit organization, Ryan's Mission, which advocates and raises money for Type 1 diabetes research.

Reed will host the Lilly Diabetes #DriveYourHealth Track Walk from 2 to 4 p.m. Friday at the Charlotte Motor Speedway. Lilly Diabetes will make a donation to the American Diabetes Association Charlotte Chapter for each participant who reaches the finish line.

Reed will also sport the Lilly Diabetes logo on his No. 16 Ford Mustang at the NASCAR Xfinity series events at the speedway this weekend.

Miles and his family have already been doing their part. The family has participated in five Juvenile Diabetes Research Foundation One Walks and mentored several families who are new to Type 1 diabetes.

As for what Miles hopes his talks with Congress will yield for type 1 diabetes, he says optimistically a cure.

You can reach Eric Wildstein at 704-869-1828 or Twitter.com/TheGazetteEric.

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Nutrition Corner: Control diabetes with low-carbohydrate vegetable – The Sunday Dispatch

Posted: May 26, 2017 at 8:40 am

Nutrition Corner Mary R. Ehret

The number of people affected by diabetes and pre-diabetes continues to grow. In our area, 11 percent of the population more than one out of 10 people have diabetes. How many are undiagnosed? Nationwide, 9.3 million, or 21 percent of the population has diabetes. According to the America Diabetes Association, another 8.1 million, or 28 percent, could be undiagnosed.

Diabetes is a disease that occurs when blood glucose, also called blood sugar, is too high. Over time, having too much glucose in blood can cause health problems like heart disease, nerve damage, eye problems and kidney disease. Steps can be taken to prevent diabetes or manage it.

Some key symptoms of diabetes include pain or numbness in the hands and feet, feeling very thirsty, extreme fatigue, blurry vision and slow healing cuts or bruises. See a health care provider if even a mild case of any symptom occurs.

Hearing the diagnosis of diabetes may make one feel like theyve had something taken away a favorite food, going out to eat and eating dessert all may be standing in the way of good health. Seeing a dietitian may help get over some of these obstacles. Attending a Diabetes Self-Management Education Program may increase knowledge of how food, physical activity and medication all work together to maintain a healthy blood-glucose level.

One of the food groups closely monitored and balanced with medication is carbohydrates. Whether it comes from fruit, vegetables or a sweet dessert, carbohydrates require insulin to be absorbed into the body. If a sufficient amount of insulin or low-quality insulin is available, the carbohydrate will stay in the blood stream. That is where the saying sugar, or high sugar, comes from.

Fruits and vegetables are healthy because they contain fiber, vitamins and minerals. However, they are carbohydrates and counted in the meal plan like any other food. Fruits and vegetables also contain water, which gives a filling effect, so low-carbohydrate vegetables are a great addition to any diet. Its also a dietary component people arent getting enough of.

Here are some examples of low-carbohydrate vegetables: cucumbers, peppers, yellow squash, carrots, celery, cabbage, broccoli, cauliflower, tomatoes and green beans.

Include more of these vegetables every day. They have between two-to-six grams of carbohydrates per half-cup serving, which is much less than the 15-gram carbohydrate exchange suggestion for a serving of starchy vegetables or breads.

For a free copy of Pennsylvania Produce Guide, which lists all the fruits and vegetables food labels, call 570-825-1701.

This recipe uses two low-carbohydrate vegetables: summer squash and tomatoes.

Summer Squash Medley

1 onion, small

1 tablespoon olive oil (or canola oil)

1 1/2 yellow summer squash, small and sliced (can use 1-2 squash)

1 1/2 zucchini, small and sliced (can use 1-2 zucchini)

1/4 teaspoon garlic powder

pepper (to taste, optional)

1 can diced Italian tomatoes (14.5 ounces)

2 tablespoons Parmesan cheese (grated)

In large skillet, heat oil. To heated oil, add squash and onion. Cook on medium heat until tender, about 10 minutes, stirring often. Add tomatoes and simmer 5 minutes.

Season with garlic powder to taste. Add pepper (optional), if desired. Serve warm, top with Parmesan cheese. Enjoy!

Nutrition Corner Mary R. Ehret

http://psdispatch.com/wp-content/uploads/2017/05/web1_Ehret.CMYK_-3.jpgNutrition Corner Mary R. Ehret

Mary Ehret is the Penn State Extension Nutrition Links Supervisor in Luzerne, Lackawanna, Monroe, Carbon, Sullivan and Bradford counties. Reach her at 570-825-1701 or at [emailprotected]

.

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Diabetic student’s service dog makes Stafford High’s yearbook – Fredericksburg.com

Posted: May 26, 2017 at 8:40 am

When Stafford High School students flip through the yearbook for the first time, they get to page 220 and gasp with surprise, Its Alpha!

Although Alpha goes to school every day like all the other students featured in the recently released yearbook, he is also a little different: Alpha is a service dog.

Alpha belongs to Andrew AJ Schalk, a 16-year-old junior at Stafford High who has Type 1 diabetes. The service dog alerts him when his blood sugar levels are too high or low by giving Schalk his paw.

He lets me know my blood sugar is fluctuating through smell anywhere from 20 to 40 minutes before I even know anything is wrong, Schalk said.

Grace Fuller, a 17-year-old junior who is on the yearbook staff, featured Alpha in a small profile in last years annual. As she sorted through this years student headshots, a photo of Alpha popped up and she knew it needed to be included.

AJ has always talked about how much he liked having Alpha at school, and he is here all the timewe see him in class and in the hallways, she said. He is a part of this school now.

A Stafford student tweeted about Alphas inclusion in the yearbook, and that post was shared thousands of times and prompted a Buzzfeed story on Wednesday that has been shared widely on social media.

Schalk started bringing his service dog to school with him last year. At first, he would take him only one day a week to get him acclimated to the new environment. Now, Alpha goes everywhere with him, including on the bus and to class.

When Alpha first started coming to school, Schalk observed many students turning their heads and saying, Wait, is that a dog? But, over the past few months, the unfamiliarity has faded, and most of the students recognize him now.

Schalk said everyone has been very accepting of having a service dog around the school. So, he wasnt surprised when he and Fuller went to his teachers and school administrators with the idea to include his four-legged friend in the yearbook and they were all for it.

Everyone has been a hundred percent supportive of him from the very beginning, Schalk said.

Schalk uses a number of tools to manage his diabetes, but Alpha has made the biggest difference in helping him to live a normal, full life.

It has turned my disability into a positive experience, Schalk said.

Alphas presence in the school has not only helped Schalk, but also other students, as well.

Schalk said his furry companion instantly lights up the school environment when they walk through the doors in the morning, and everyone looks happy to see them. Students wave and smile, and teachers say hello when the inseparable pair walk into class.

Alpha brightens the school atmosphere for all of the studentsnot just me, Schalk said. I love knowing that were having that effect on so many people.

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HRRMC receives grant for diabetes prevention outreach – Chaffee County Times

Posted: May 26, 2017 at 8:40 am

Heart of the Rockies Regional Medical Center Foundation was one of seven local nonprofit organizations awarded a grant by the Climax Area Community Investment Fund on May 3. The fund supports programs and projects that promote health and wellness.

The $41,500 grant will support a unique partnership between Heart of the Rockies Regional Medical Center in Chaffee County and St. Vincent Hospital in Lake County to implement the National Diabetes Prevention Program, a nationally recognized diabetes prevention program. Education and improved access to quality health care can help individuals at risk for diabetes. The funds will also be used to increase the availability of fitness, nutrition and other health education in the region.

The National Diabetes Prevention Program is the most effective intervention for lifestyle change that I've seen in my 20-year career, said HRRMC Wellness Supervisor Jon Fritz.The group class is led by a trained coach and encourages increased activity and decreased caloric intake. The answers are simple but the process is challenging and that's why trained coaches follow an evidence-based curriculum which has proven effective.

Chaffee County has had an NDPP program since 2013. Lake County and St. Vincent Hospital have identified diabetes prevention as a focus in their community. HRRMC will offer assistance in starting an NDPP program while expanding classes throughout Chaffee County.

HRRMC Foundation director Kimla Robinson accepted the award along with Fritz on behalf of the hospital. We are so honored to receive the Freeport-McMoRan Climax Area Community Investment Fund Grant and partner with St. Vincent Hospital to implement a diabetes prevention program, she said.

The Climax Area Community Investment Fund was established in 2011 to focus on programs and projects that help create sustainability and reduce dependency on any single industry. Eligible programs and projects include those in the areas of education, community and economic development, environmental stewardship, and health and wellness. A committee comprised of community leaders representing diverse organizations and two Freeport-McMoRan representatives governs the Fund.

For more information on the NDPP program, call the HRRMC Wellness Department at 530-2057.

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Giraffe ‘sneakers’ in use at the Cheyenne Mountain Zoo! – KKTV 11 News

Posted: May 24, 2017 at 7:47 pm

COLORADO SPRINGS, Colo. (Cheyenne Mountain Zoo) - The Zoos veterinary and animal care teams have utilized both stem cell transfusion therapy and custom-made urethane sneakers to treat giraffe here at the Zoo. The efforts are led by Dr. Liza Dadone, vice president of mission and programs and head veterinarian for Cheyenne Mountain Zoo.

Dr. Dadone and staff of the Colorado State University James L. Voss Veterinary Teaching Hospital were able to grow stem cells from giraffe blood to then inject back into the giraffe a treatment for giraffe that is believed to be the first of its kind in the world.

Giraffe "sneakers, Cheyenne Mountain Zoo."

Mahali, the 14-year-old male giraffe treated, suffered from chronic lameness and had not been moving well, despite a number of medications and additional treatments the animal care and veterinary teams gave him. Dr. Dadone decided on a ground-breaking stem cell injection treatment plan. In scientific studies, stem cell therapy has proven to repair damaged tissue at the cellular level.

Its been nearly a month since the procedure, when Dr. Dadone and the Zoo team, along with the partnership of the CSU veterinary medicine program, injected Mahali with around 100 million stem cells. The success of the procedure was determined by Dr. Dadone when she reviewed and compared thermographic images taken of Mahalis front legs before and after the procedure. The photos show a considerable decline in inflammation in Mahalis front left leg, which is the one he had been having issues with for some time.

This is meaningful to us not only because it is the first time a giraffe has been treated with stem cells, but especially because it is bringing Mahali some arthritis relief and could help other giraffe in the near future, Dr. Dadone said.

Dr. Dadone said she is not sure if Mahalis positive results are simply due to the stem cell therapy or are a combination of different treatments, but shes pleased and assured his quality of life has dramatically improved.

Prior to the procedure, he was favoring his left front leg and would lift that foot off the ground almost once per minute, Dr. Dadone said. During the immobilization, we did multiple treatments that included hoof trims, stem cell therapy and other medications. Since then, Mahali is no longer constantly lifting his left front leg off the ground and has resumed cooperating for hoof care. A few weeks ago, he returned to life with his herd, including yard access. On the thermogram, the marked inflammation up the leg has mostly resolved.

Another Zoo giraffe, 14-year-old female Twiga, has advanced arthritis and osteoporosis in her feet. Dr. Dadone and the veterinary team have been monitoring and treating her condition for some time, but were hopeful when they heard of a farrier specialist who had an idea to make custom shoes for her. Weve had Twiga on medicine to help reverse her osteoporosis, but we wanted to do more to protect her feet. So with the help of the farriers, we gave her giraffe sneakers to help give her some extra cushion, said Dr. Dadone.

To get the sneakers onto Twigas feet, the keepers cued Twiga to place her hoof on a specially-designed hoof block, then farriers Steve Foxworth and Chris Niclas of the Equine Lameness Prevention Organization (ELPO) did a routine hoof trim to the foot, a procedure Foxworth performs monthly. Once her foot was clean and ready, the shoe was placed on her sole by Niclas with quick-drying glue. The sneakers are divided on the undersides and were designed by Niclas to adjust to Twigas individual digits.

Dr. Dadone said the change in Twigas behavior was immediate. Twiga instantly shifted her weight off of her right foot, indicating she was comfortable and her pain had considerably lessened. The shoes help to stabilize Twiga and will likely stay on for around six weeks. Dr. Dadone says they will reassess Twigas progress at that time. She is eager to share information regarding this treatment option so that other veterinary teams at fellow zoos can use this technique to help benefit their animals as well.

Large animals like giraffe are susceptible to issues like arthritis and osteoporosis, mainly stemming from their sheer size. Like all animals, these issues are exacerbated as they age. So much of it just relates to the pure mechanics of weighing a ton, Dr. Dadone said.

Other regular veterinary treatments include X-ray imaging, laser therapy, hoof care and more.

Cheyenne Mountain Zoo is not only a leader in the training and health of giraffe in human care, but they are also making a huge difference in conservation of giraffe in the wild. The status of giraffe was recently changed by the International Union for Conservation of Nature (IUCN) from least concern to vulnerable, acknowledging the fact that their population in the wild has plummeted by 40 percent in the last 30 years.

Last year, Cheyenne Mountain Zoos guests and members used their Quarters for Conservation (Q4C) admission contributions to send $26,000 to the Giraffe Conservation Foundation (GCF) and its efforts to help the Rothschilds giraffe in Murchison Falls National Park in Uganda.

Cheyenne Mountain Zoo is home to the worlds most prolific captive reticulated giraffe herd, with 199 births at the Zoo since 1954. Guests can get up close and hand-feed them on special indoor and outdoor elevated platforms anytime during the day, 365 days a year.

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Giraffe 'sneakers' in use at the Cheyenne Mountain Zoo! - KKTV 11 News

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For the first time ever, researchers produced lab-grown blood stem cells – Colorado Springs Gazette

Posted: May 24, 2017 at 7:47 pm

Caption + Shutterstock By SebGross

In two separate studies, researchers have successfully created blood stem cells in a laboratory setting for the first time. These types of cells are found in bone marrow and can be depleted by diseases like leukemia and even by the treatments for those diseases, such as chemotherapy.

George Daley, Dean of the Faculty of Medicine at Harvard, and his team started with pluripotent stem cells, which can give rise to just about any type cell in our anatomy. By looking at what proteins controlled the genes in bone marrow cells, they were able to isolate several that were essential to cell differentiation (the process by which stem cells become a specific kind of cell). They then applied them to the pluripotent cells in order to encourage them to turn into the cells found in bone marrow.

Another team lead by Raphael Lis, Instructor in Medicine at Weill Cornell Medical College, took cells from the lungs of animals, and found four factors that encourage the lung stem cells to make blood stem cells. In their report they demonstrate a tractable approach for fully reprogramming adult mouse endothelial cells to haematopoietic stem cells. The next steps for Lis are to streamline the conceived [] reproducible approach to manufacture engraftable durable blood cells, so they can be produced on a larger scale.

Read the full story at Futurism.com.

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For the first time ever, researchers produced lab-grown blood stem cells - Colorado Springs Gazette

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Chattanooga Student Surprised to be a Gift of Life Donor – WDEF News 12

Posted: May 24, 2017 at 7:47 pm

Most of us like to give gifts to others. Sometimes theyre small or sentimental-but they can be once in a lifetime events. At the top of the list is the gift of life, and a UTC student had the chance to do that. Page McCoy had developed leukemia-some didnt give her much hope.

M.C. She needed a stem cell transplant and fortunately there was exactly one match in the world. And it was a donor in the Gift of Life register. Her transplant took place in January 2016 in Denver. Colorado. She had a long and difficult recovery but today she is here and she is real excited to meet the donor who saved her life.

That was the way this story unfolded last week in New York as the Gift of Life foundation honored Americans who were registered donors and the people they helped. The donor in this case was a 22-year old student at UTC who registered two years ago in Knoxville two years ago, and promptly forgot all about it. Thomas Davis was surprised to get the call but he didnt hesitate to go through with the STEM cell transplant.

THOMAS DAVIS, UTC STUDENT AND DONOR Followed all the steps, and eventually I was outside D.C.with two needles in the arms, donating the stem cells.

Thomas was invited to the Gala last week where he would actually meet Page for the first time.

(WALKS UP AND HUGS HER )

THOMAS DAVIS out of nowhere, hearing, o.k. Shes on track to recovery..its awesome and the opportunity to actually meet heruhit was wonderful.

Both Thomas and Page McCoy got to make a few comments on stage.

THOMAS Thank you, to the generous men and women whose financial contributions make Gift of Life possible, really..I wouldnt be on stage without you guys, we wouldnt be here together if it wasnt for you guys who made Gift of Life a reality.

PAGE MCCOY, STEM CELL RECIPIENT My donor gave me back my life..but he also gave me my future. Im leukemia free and 100% engrafted because of himapplause.

Thomas wants to build that donor list for Gift of Life.

THOMAS Theres nothing to be afraid of..no reason not to.

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