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UMN research team fixes broken hearts with 3D-printed tissue patch – Minnesota Daily

Posted: April 27, 2017 at 10:47 am

A research team at the University of Minnesota found a way to heal broken hearts.

Researchers used a 3D printer to create protein patches that mimic heart tissue to treat post-heart attack scars. The research is in collaboration with the University of Wisconsin-Madison and the University of Alabama-Birmingham.

Brenda Ogle, a University biomedical engineering professor and lead researcher for the project, said she and her team have investigated proteins that surround cells in the body for 15 years. The team has been studying how the proteins also called the extracellular matrix influence stem cell behavior.

For many years, weve been trying to develop optimum formulation that can support stem cells in new cardiac [cell] types, Ogle said, adding that theyve focused on cardiac cell types to figure out a way to strengthen them after the muscle cells are damaged and die during a heart attack. Its one of the cell types in the body that cant be recovered.

The team successfully treated mice with the patches and is now planning to test the method on larger animals.

Molly Kupfer, a doctoral student who is part of Ogles team, said a heart attack occurs when there is a blockage in a primary blood vessel that delivers oxygen and nutrients to the heart.

When that happens, you have cell death in the area of the heart that doesnt receive the appropriate oxygen and nutrients, Kupfer said. Those cells that die arent able to recover."

Typically, after a heart attack, the blood clot in the heart is removed at a hospital, and if the heart has not been damaged too badly, doctors monitor the heart long-term, prescribe medicine and regularly check for signs of heart failure, Ogle said.

What you get instead after a heart attack is scar tissue forming, and that scar tissue ultimately fails, Ogle said.

Associate Professor Brenda Ogle places a 3D printed biopatch on a mouse heart in Nils Hasselmo Hall on Tuesday, April 25, 2017. Her research team induces heart attacks in mice, which causes a dead area of cardiac cells. The patch is placed in this dead zone and mimics the cells of the native heart that aren't able to be replenished on their own.

Kupfer said she worked with Paul Campagnola and his lab at the University of Wisconsin to print the patches; the cells were prepared at the University of Minnesota.

Campagnola, a biomedical engineering professor, said he initially developed the underlying printing technology in 2000.

"The idea of the patch is it could actually behave like native cardiac tissue and assist the function of the heart, Kupfer said, adding that the method used to print the patches results in extremely high resolution structures.

Ogle said before applying the patch to the animal hearts theyre currently testing on, they take a scan of the scarred tissue and create a digital template for the 3D-printer to follow and print the proteins in the same pattern.

Campagnola said the patch provides a stable space for cells to grow and be implanted in damaged areas.

Cardiac cells are also added to the patch when it covers a damaged area. Ogle said it not only provides a support structure, but transplants healthy cells that will eventually become integrated into the heart, stabling it structurally and functionally.

A huge aha moment was when [the cardiac cells] started to beat on this patch synchronously and spontaneously, she said. When that happened, we realized that this could be a viable therapy for the heart, a way to replace those lost muscle cells.

Through the research group at the University of Alabama, Ogle said a study was conducted where the patch was tested on dead or dying tissue in mice hearts and the group saw improvement in the mice after four weeks.

The project was funded through a series of grants from the National Institutes of Health, the National Science Foundation with support from the University, she said.

The group has since received larger funds from the NIH to run a study using the patch on larger animals within the next year.

Ogle said it would take about 10 years until the patch can be used on human patients in a clinical setting.

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Bengals set to hold onto McCarron for at least 1 more year | Sports … – Newsexaminer

Posted: April 27, 2017 at 10:47 am

CINCINNATI Bengals backup quarterback AJ McCarron is looking at another year of barely getting on the field, and maybe longer.

With the draft a few days away, Cincinnati has given no indication its willing to trade him to a team that would give him a bigger role. Its a challenging situation for McCarron, who proved he could lead a team into the playoffs in 2015 if given the opportunity.

As a competitor, you always want your chance to play, McCarron said Monday. But it will happen. I just have to wait my time. I believe that, and I trust in my ability to keep showcasing what I can do and then get my opportunity.

The two-time national champion at Alabama got his chance when Andy Dalton broke the thumb on his passing hand late in the 2015 season. McCarron, a fifth-round pick, started the last three games and won two of them. His late touchdown pass to A.J. Green had Cincinnati ahead in the closing minutes of a playoff game against Pittsburgh before a pair of defensive penalties helped the Steelers move in range for the winning field goal.

Last year, he was relegated to a backup role again, getting into only one game without throwing a pass.

Although theres great demand in the NFL for starting quarterbacks, the Bengals havent shown an inclination to trade him. Theyre content having him as the backup in case Dalton gets hurt again.

Its great to be wanted, it really is, McCarron said.

Even so, its difficult to go back to being the backup after leading a team to the playoffs. Dalton has been extremely durable during his six-year career the broken thumb was his only significant injury so the odds are against McCarron getting much chance to play until his contract ends.

Hes in a situation similar to Jimmy Garoppolo in New England, which hasnt shown an inclination to trade Tom Bradys backup.

McCarrons original deal runs through this season, but theres a catch. He showed up for training camp with a sore shoulder as a rookie in 2014 and was unavailable for most of the season, which could affect his status. Instead of being an unrestricted free agent, the Bengals think he should be a restricted free agent after the 2017 season because he missed most of his rookie season.

As a restricted free agent, McCarron could wind up spending the 2018 season in Cincinnati as well.

Were still going through all that, McCarron said. And its probably going to go into next year. Its just something theyre going to fight on their side and something Im going to fight on my side to prove why I shouldnt have to have another year.

McCarrons eagerness to move into a starters role is tempered by his appreciation for how the Bengals drafted him. They stuck with him after he missed most of his rookie season because of the sore shoulder, which improved after he got stem cells injected. In a year or two, hell get his chance.

There were some quarterbacks that got some pretty nice pay days this offseason, McCarron said. Hopefully in my future, one of those days is coming up.

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Improving Joint Health with Putative Therapeutics at Matis, Iceland’s Food & Biotechnology Research Institute – SelectScience

Posted: April 27, 2017 at 10:47 am

Use of cell imaging technology enables cutting-edge research into the assessment of bioactive compounds in cell lines

Matis is a leading food and biotechnology research institute in Iceland. Matis vision is to increase the value of food processing and food production, and to ensure the safety and quality of food and food products. SelectScience spoke to Dr. Eva Kuttner, to learn more about the technology the company is using in its research.

SS: Could you briefly introduce yourself and your place of work?

EK: My name is Dr. Eva Kuttner, Im a Project Leader in the Analysis and Structure division at Matis (mat=food + is=Iceland). Matis is a government owned, non-profit, independent research company in Iceland. The main focus of Matis is research and development, aligned to the food and biotechnology industries, as well as providing Iceland's leading food analytical testing service for public and private authorities.

I personally am German, and I hold a Diploma (equal to an MSc) in Botany, from the Universitt Braunschweig in Germany. I received my PhD in Integrative Biology (2007-2012) from the University of Guelph (Ontario, Canada).

SS: Could you describe your job role and work at Matis?

EK: My job title is Regional Manager, which means I am responsible for the 2 locations of Matis in the North of Iceland, Saurkrkur and Akureyri. My main work is that of a project leader (bioactives) in the Analysis and Structure Division and I am specialized in screening for bioactive secondary metabolites using in vitro chemical and cell-based assays.

Our laboratory focus is on identifying and describing compounds regarding antioxidant activity for healthcare (anti-diabetes, anti-inflammatory) and skin care. We now have a fully equipped cell laboratory (currently working with two cell lines), and we routinely run chemical and cell-based assays to identify and describe the bioactivity properties of extracted and fractionated compounds.

Testing putative therapeutics

SS: Please tell us about your marine compounds project that you are working on, and the main challenges involved?

EK: We are currently looking into how marine compounds influence the mineralization in a murine chondrocyte cell line (ATDC5). The aim of the project is to test putative therapeutics, to improve joint health. Specifically, we are interested in seeing how they affect differentiation of these cells.

SS: Which methods do you use to investigate this project and how does the BioTek Cytation 5 play a part in this?

EK: We are exposing the cells to different concentrations of fractionated marine compounds in a 96-well microplate format. After 24 days of incubation we stain the cells both with calcein and Alizarin Red to quantify calcium deposition. This is when the Cytation 5 from BioTek comes in: we have a workflow set up that images (magnification 4x) each well in phase contrast and fluorescence (we are using a GFP filter cube for this assay), and also carries out a read of the fluorescence signal. We then perform the Alizarin Red staining, take more pictures and extract the bound color after several washing steps. A further reading step quantifies the Alizarin Red using an absorbance read.

The figure below shows an example read of the calcein stain: first picture, phase contrast, second picture, fluorescence channel (GFP filter cube) and the third picture, overlay of both:

Image courtesy of Dr. Eva Kuttner

SS: What are your main research findings so far?

EK: We have identified several possible inhibitors of mineralization, but we are still in the process of improving the assay protocol to make the quantification of the mineralization more reproducible. The Alizarin Red stain has proven to represent more accurate calcium deposition into the cells, when testing the assay protocol using standard inhibitors like levamisole, so we are using the calcein stain to visualize mineralization, and Alizarin Red to quantify.

SS: What is the future of your research?

EK: We are looking into setting up assays investigating blood pressure. Our project partner developed a product line based on fish protein hydrolysate using trimmings from cod (Gadus morhua). The proteins are extracted and broken down to smaller peptides that have been shown to inhibit a key enzyme involved in increasing blood pressure (ACE). For this research we will develop and perform cell-based assays.

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250598 Shares in Puma Biotechnology Inc (PBYI) Acquired by Norges Bank – The Cerbat Gem

Posted: April 27, 2017 at 10:46 am

250598 Shares in Puma Biotechnology Inc (PBYI) Acquired by Norges Bank
The Cerbat Gem
Puma Biotechnology logo Norges Bank acquired a new position in Puma Biotechnology Inc (NYSE:PBYI) during the fourth quarter, according to its most recent Form 13F filing with the SEC. The firm acquired 250,598 shares of the biopharmaceutical ...
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3D Systems and United Therapeutics partner to 3D print organ scaffolds for human transplants – TCT Magazine

Posted: April 27, 2017 at 10:46 am

3D Systems has announced a bioprinting agreement with United Therapeutics which will see the two companies develop solid-organ scaffolds for human transplants with 3D printing.

Combining their respective expertise in 3D printing and regenerative medicine and organ manufacturing, the collaboration will remain for a number of years.

The agreement will pit 3D Systems personnel alongside professionals from a United Therapeutics subsidiary, Lung Biotechnology PBC. Since the collaboration will primarily focus on the development of 3D printing systems for solid-organ lung scaffolds, Lung Biotechnology PBC is seen as best placed to work with 3D Systems.

The printing system will target collagen, and other building block proteins, as scaffold raw materials. Lung Biotechnology PBC will cellularize the scaffolds with patient-specific biological material, including re-differentiated stem cells.

Our partnership with 3D Systems is a major step forward in creating an unlimited supply of tolerable transplanted organs, said Martine Rothblatt, Ph.D., Chairman and Chief Executive Officer of United Therapeutics. By cellularizing scaffolds created with 3D Systems printers with a patients own cells, there will no longer be a need for immunosuppression and a vastly greater number of patients can extend their enjoyment of life through organ transplantation.

3D Systems is a company with a wealth of experience in the medical sector. Its precision healthcare capabilities include simulation, virtual surgical planning, and the printing of medical and dental devices. Two of 3D Systems leading executives are not only confident in their companys own knowledge of the medical 3D printing sector, but also of United Therapeutics own expertise. Though conceding the challenge is not straight forward, the pair foresee new solutions being born from the partnership.

As a global leader in healthcare solutions, we are part of many developments and applications for 3D printing coming together including bioprinting, said Vyomesh Joshi, Chief Executive Officer, 3D Systems. We believe bioprinting is a powerful opportunity and we are uniquely positioned with the broadest portfolio of technologies to partner with companies of the calibre of United Therapeutics to provide healthcare solutions of the future.

Chuck Hull, Executive Vice President, Chief Technology Officer, 3D Systems, added: Combining the resources of United Therapeutics and 3D Systems transforms our capability to tackle this difficult challenge. This project will be based out of our new bioprinting lab in San Diego, CA, and will rely on expertise across many technical disciplines within 3D Systems as well as the domain knowledge of our technical partners at Lung Biotechnology PBC.

Meanwhile, the collaboration and joint development will add another technology alternative to United Therapeutics pursuit of an unlimited supply of organs for human transplantation.

Dr Rothblatt concludes: Our Lung Biotechnology public benefit corporation is taking personal regenerative medicine to its highest level yet with this practical, economic solution to a major health care program. Indeed, we expect one personalised organ transplant will avoid years of health care spending on palliative medical therapies.

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Lonza US cell therapy plant slapped with FDA warning letter – FiercePharma

Posted: April 27, 2017 at 10:44 am

Swiss CDMO leader Lonza has had its cell therapy facility in the U.S. slapped with a warning letter after halting some production there two months ago because of sterility problems with a product it was producing for a client.

The company acknowledged the FDA action in its first-quarter earnings report Tuesday, saying that the warning letter was issued Monday for its facility in Walkersville, Maryland. The FDA had concerns about issues including validation and aseptic process simulations, the drugmaker said.

Lonza takes this issue seriously, and has already started to address all issues raised by the FDA, the company said.

Lonza first learned about the issue in December after product end-user notified the FDA of the issue, Lonza spokeswoman Constance Ward said in an email Tuesday. Lonza opened an investigation after confirming the sterility issue. She said the plant halted production of the product in the affected manufacturing area in early February, while also quarantining the inventory it had on hand.

"After inspecting both the customer of the product and the Walkerville operations, the FDA issued Lonza a warning letter that identified issues involving validation, aseptic process simulations, corrective and preventive actions, and environmental monitoring, Ward explained.

She said the company expects to have the problems resolved and FFM media manufacturing back online by mid-2017. The company had already begun a $7.6 million manufacturing upgrade at the facility, which Ward said is slated to be finished in 2018.

While the drugmaker said it expects the latest FDA action to have minimal impact on revenues of its Pharma & Biotech segment, it reported sales in the segment were softer in the first quarter because of the action. Without providing specific numbers, the contract manufacturer Tuesday reported that growth in that segment was driven by demand in mammalian manufacturing, as well as in clinical development and licensing.

This is not the first time that Lonza has faced FDA concerns about its biologics operations in the U.S. An API plant it had in Hopkinton, Massachusetts, was cited in 2011 over a plethora of problems, creating supply problems for a drug it manufactured there at the time for French drugmaker Ipsen. After struggling to get issues resolved, Lonza simply closed the plant and concentrated its biologics work at its extensive site in Visp, Switzerland.

Lonza is preparing to expand its Visp biologics capability further. It will break ground in the second half of the year on a new large-scale biologics production facility that it is building in partnership with Frances Sanofi. The companies announced in February that they would share the cost, and capacity, of a 270 million ($286.3 million) plant at Lonzas site in Visp.

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HemaCare Will Attend International Society of Cell Therapy in … – Business Wire (press release)

Posted: April 27, 2017 at 10:44 am

LOS ANGELES--(BUSINESS WIRE)--HemaCare Corporation (OTCBB: HEMA), a leader in cell and tissue collection, processing and cell therapy solutions, will be exhibiting at the annual meeting of the International Society of Cell Therapy (ISCT) in London, UK, May 3-6, 2017. This year marks the 25th anniversary of the ISCT, a global society that unites clinicians, researchers, regulators, technologists and industry partners with a shared vision to translate cellular therapy into clinical practice. HemaCare will meet with its customers and European distributors at the conference and showcase its growing portfolio for cell therapy developers around the world.

Attending this meeting enables us to capture the latest developments in cell therapy and better serve our customer needs, said Pete van der Wal, Chief Executive Officer for HemaCare.The field of cell therapy is rapidly evolving. Our products and services are embedded in some of the most critical phases of translational research, enabling scientists to work with high quality human cells from our well-characterized donor pool.

The conference is being held at ExCel London Conference Center. Look for us there, or view our products and services at http://www.hemacare.com.

About HemaCare

HemaCare specializes in the customization of human-derived biological products and services for customers research and cell therapy protocols. HemaCares network of FDA-registered, GMP/GTP-compliant collection centers ensures donor material is available for fresh shipment to customers, as well as for internal use within HemaCares isolation laboratory. In this laboratory, human biological material such as peripheral blood, bone marrow, and cord blood from donor and patient subjects is isolated into various primary cell types for distribution to customers in fresh and frozen formats. HemaCare's extensive registry of well-characterized repeat donors provides consistent primary human cells and biological products for advanced biomedical research and cellular therapy process development.

For 39 years, HemaCare has provided human-derived primary blood cells and tissues for biomedical research, supported cell therapy clinical trials and commercialization with apheresis collections, and provided a wide range of consulting services. HemaCare directly supports benchtop immunology and oncology research, compound screening for drug discovery, and assay development and qualification, as well as enables customers to advance both autologous and allogeneic cellular therapies. For more information, please visit http://www.hemacare.com.

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Overcoming diabetes through churches in Columbia’s African-American community – Columbia Missourian

Posted: April 27, 2017 at 10:43 am

COLUMBIA Verna Laboy's paternal grandmother lost both legs to diabetes complications. Very recently, one of her cousins lost a leg also to diabetes. Yet another cousin is on dialysis, a complication of the same disease.

"This is personal for me," she says.

She doesn't pretend to be an expert that's not where the passion comes from. She, herself, was "on the fast track" to diabetes and has found it hard to stick with an exercise or diet.

All of that has made Laboy a passionate force behind Live Well By Faith, a wellness program launched one year ago through the Columbia/Boone County Health and Human Services Department for black churches in Boone County.

Data from a county-wide survey in 2013 showed that of the 9,300 people living with diabetes in Boone County, black people were four times more likely to die from complications related to the disease than their white counterparts. Nationally, black women are just under two times more likely than white women to die from diabetes complications, while black men are about one and a half times more likely than white men to die from diabetes complications, according to the Centers for Disease Control and Prevention.

Type 2 diabetes the more common form of the chronic disease occurs when the level of blood glucose (sugar) in a person's body is higher than normal because insulin ceases to be produced properly, according to theAmerican Diabetes Association. As a result, the body's cells are starved for energy and the eyes, kidneys, nerves and heart can be effected. Factors associated with diabetes include obesity, a family history of the disease and race and ethnicity.

Verna Laboy saves leftover food April 2 after the Live Well By Faith cooking class. Laboy runs the Live Well By Faith wellness program through St. Luke United Methodist Church in Columbia, which aims to address health disparities in minority communities through church programs.

Laboy, a self-proclaimed "health evangelist" and community activist, has been working with black churchgoers since April 2016 to educate people about the consequences of unhealthy lifestyles, to encourage healthy eating and to provide programsfor long-term success in health management.

"Food is important to this culture, and it's cooked the wrong way. It's a lethal digestion," Laboy said. "It's an addiction that needs to be addressed, a very unhealthy addiction. We need to increase our health literacy."

Laboy uses the word "bulldozer" to describe how she's paving the way towards bringing down the rates of diabetes and heart disease among blacks in Boone County.

"I don't have a health background. I'm not a personal trainer. I'm not a nutritionist," she said.

Her own struggle to change her lifestyle has been a source of insight.

"But I've been on this journey for years, unable to stay consistent," she said.

She and other "health ministers" at the Live Well By Faith-accredited churches are "looking for people that are dealing with the challenges themselves to adopt (healthy) behaviors and see the changes and take people on the journey with them," she said.

Laboy enthusiastically and passionately evangelizes on a healthy lifestyle.

"Verna's not doing the work," she said, slipping into third person, as she often does. "You have to do the work. This is your church. This is your congregation. This is your family. This is your life."

Diabetes can lead to high blood pressure, heart disease, amputations and death if not managed well, according to the American Diabetes Association.

Lifestyle factors and genetics are the primary influences of type 2 diabetes, according to a study published in 2012. Type 2 diabetes involves insulin resistance and declining insulin production and components of the disease include physical inactivity, sedentary lifestyle, cigarette smoking and a generous consumption of alcohol.

Maintaining a healthy diet for the prevention or treatment of diabetes combined with physical activity is associated with lowered risks of diabetes, according toa study published by the Journal of Education and Health Promotion. Eating smaller serving sizes and cutting calories improves insulin sensitivity, and regular physical activity helps with weight loss and may also decrease blood pressure.

Increasinghealth literacy entails learning about what types of foods are recommended for healthful living, what types of food to avoid and fitness.Focusing meal planning around nutrient dense foods such as vegetables, beans, whole grains, fruit, non-fat dairy, fish and lean meats is one way to decrease the risk of diabetes, according to theAmerican Diabetes Association.

But the church is an especially important institution for many black Americans.

From left, Frances Logan, Shae Brown and Mary B. Warren wash their hands during the Live Well By Faith cooking class April 2 in Columbia. Each attendee washed their hands for 20 seconds, which was a technique they reviewed at the start of the workshop.

Annabelle Simmons, a health minister at St. Luke United Methodist Church, joined the Live Well By Faith team . After she took a healthy lifestyle class through the program, she said her eyes were opened about health.

But she wasn't sure exactly which of the possible Life Well by Faith courses she would teach.

There it was: "Cooking Matters." She thought to herself, "I know how to cook," but had to become certified to teach it. That entailed learning about how to hold a knife properly, how to slice correctly, among other kitchen skills.

The healthy cooking and eating topics changed her habits: learning how to read food labels, how much food is in a serving, the calorie count, the protein count, etc. "And now, every time I go shopping, I'm looking at the labels, so I know it works," she said.

The class also teaches people how to cook healthy food on a budget, Laboy said: "They can see how cheap they can cook good food, healthy food."

In addition to what she learned in "Cooking Matters," Simmons also learned how to take a blood pressure reading, which she does on Sundays free if church members ask her to do so. The health ministers at St. Luke also signed off on a water policy, requiring that water be offered with every meal offered at a church event.

"People were going, 'But I want punch, I want coffee,'" Simmons said.

A "no fried foods" policy is also in place.

And yet, people still gather around the table.

"We get to fellowship with one another around food, preparing the food together," Simmons said.

Dee Campbell-Carter, a lifestyle coach for the health ministry at Friendship Missionary Baptist Church, said the church will start a "Cooking Matters" class later this year. The health ministry at Friendship Baptist offers blood pressure checks every second and fourth Sunday before and after service lets out as well as "SweatSuit Sundays," when the congregation stops in the middle of service to do high- and low-impact exercises to gospel music.

"The thing we're doing is building a faith community that's cross-pollinating," Laboy said. This means that if a class is offered at one church, all the other churches are invited to send participants.

Dee Campbell-Carter, left, and Dorothy Slaughter tend to a garden plot April 17 at Friendship Baptist's community garden. Campbell-Carter is in charge of the garden, which came to fruition in January.

As the sun set last week, Campell-Carter strolled between garden plots behind Friendship Missionary Baptist filled with budding greens, tomatoes and peppers while bees hovered over dandelion-covered grass. Campbell-Carter and community member Dorothy Slaughter tilled the soil, pulling weeds and watering mustard and collard greens and kale.

The garden is called "Friendship Gardens," and the food harvested in the plots will be used in the "Cooking Matters" class when it begins.

Half-built garden beds lay ready for the next stage: being raised on stilts for planting. They will be waist high to accommodate children or those who are wheelchair bound, Cambell-Carter said.

The garden is a placewhere church memberscan grow healthy produce to take home and cook.

Cambell-Carter described Slaughter as the go-to gardener. She taught the community how to dig weeds out from their root with a simple tools like a plastic knife, and that coffee grounds are a good fertilizer and deterrent for some pests.

Calvin Miles, another member of Friendship Baptist Church, is the handy man on site. He put the finishing touches on the community garden sign his son painted that will stand over their "harvest trailer." He also built the raised flats for youth or those with disabilities.

Healthy food fits with his spiritual life, Miles said: "Body, mind and spirit. They all come together."

Calvin Miles paints Friendship Missionary Baptist's Friendship Garden sign on April 17. Miles' son painted the majority of the sign, while Miles added the finishing touches.

"When I see things like (Friendship Gardens) take offit's just everything," Laboy said.

But not every health ministry takes root as easily nor does every program.

Paula Williams chaired the board for the Boone County Minority Health Network until it disbanded last year. The network began in 2005 with the purpose of addressing health disparities. It ultimately died due to lack of funding.

"There was no full-time, dedicated staff to keep up with the grant writing," Williams said.

Live Well By Faith is on a two-year grant from the Boone County Commission, and Laboy is optimistic about getting it renewed. "I'm letting anyone out there that's doing this kind of work know that Verna is available to take this to the next level," she said.

There's one year left on the grant. Then, the Columbia/Boone County Department of Public Health and Human Services will re-apply. "We are just getting started," Laboy said.

She recognizes that it takes time to change a culture.

"We have to make different choices," she said. "We're living longer. Do you want to live in a nursing home? Do you want illness to take you out in such a way where someone who doesn't want to take care of you is forced to take care of you? It's a tough conversation to have, but someone has to put it out there."

Churches around Boone County are having that conversation. Laboy hopes "Cooking Matters" will be offered in 15 African-American churches in the upcoming year. Urban Empowerment Ministries has a Weight Watchers program with 22 members representing five different church communities.

Five other churches are interested in the upcoming "Eat Healthy, Be Active" program, Laboy said. She and six trained lifestyle coaches from those health ministries will be meeting to talk about bringing the curriculum to those five churches. The Columbia/Boone County Department of Public Health and Human Services has a "Shazzy Fitness" program that brings community members together to work out to gospel music.

"These are small ways we're chipping away at the health literacy and health consciousness of people," Laboy said.

Dorothy Slaughter removes weeds from her garden plot on the evening of April 17. The garden, a part of the Live Well By Faith program at Friendship Missionary Baptist Church, is open to community members to grow healthy produce to use in their meals.

"This is the hardest work I've ever done," Laboy said. "And it's taking care of myself. Why is that so hard to do? Because we're going against the grain; it's going against the culture," she said. "Great-grandma made the biscuits this way. Grandma made the greens this way. Mom makes the cobbler this way. So our tastes have adjusted, but it's killing us."

There are healthier ways of doing things, Simmons said. "You start developing a habit of being healthy rather than choosing the cake. It's been a long time since I've had cake, now. I want cake; I love cake! But it's an unhealthy choice."

Laboy shared similar sentiments. "You've got to be able to tell yourself no," she said.

"This is a lifestyle transformation change for me and I have to do it. If no one else does it, Verna has to show up for Verna."

Laboy shares her experiences on the Live Well By Faith Facebook page regularly, reminding those who are on the journey with her that they can succeed even if some days are hard. "Victory I make it to the gym this morning and boy was it a struggle. I wanted to quit!" she shared in a recent post.

"Setbacks are set-ups for a come back!" she wrote in an earlier post.

Campbell-Carter faced a setback as well. "I had to creatively regroup my workout plan when my (Activity and Recreation Center) membership expired last December," she said. Her insurance stopped reimbursing her for the membership, but she said she knew she wanted to stay active.

Campbell-Carter ultimately chose to start budgeting for weekend classes, and during the week she does yoga, gardening or goes on a "PRAYER walk," which is the term used in the Friendship Baptist health ministry to describe a neighborhood walk a group or individual can participate in. "It's great to feel increases in my muscle strength and tone. Also, I sleep so good at night," she said.

Laboy sees the proof at the gym, not just in herself but in others.

"When I'm at the gym working out and I see some of my diabetes self-management folks walking around on the track or working out on the equipment, my heart just smiles," she said.

But there's so much more to do."I can't just plant the seed and leave," Laboy said. "I have to keep coming back and watering it, and when I come, I'm coming with a tank of water and fertilizer."

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Smartphone-Controlled Cells Keep Diabetes In Check – IEEE … – IEEE Spectrum

Posted: April 27, 2017 at 10:43 am

Smartphones can already control homes and cars, anddiagnosediseases. Chinese and Swiss researchers now show that a smartphone can command engineered cells implanted in diabetic mice to produce insulin.

The researchers demonstrated a clever closed-loop system in which a digital glucometer transmits data on the rodents blood glucose levelsto a smartphone, which processes the data and then signals the implanted cells to deliver insulin.This is a step towards a new era of personalized, digitalized precision medicine, says Haifeng Ye of East China Normal University,who led the work reported in Science.

Cell-based therapies are a radical new medical treatment option being investigated by researchers. The idea is to turn cells into disease-fighting weapons by engineering them to produce therapeutic chemicals and proteins that they would churn out once implanted in the body. Living white blood cells, for instance, have been designed to fight cancer, HIV, and other diseases.Hundreds of cell therapies are undergoing clinical trials. But none can be controlled from outside the body.

Ye and his colleagues have come up with an innovative way to add smarts to cell-based therapy. They chose diabetes as the target disease.

They initially inserted light-sensitive bacterial proteins into mammalian cells. When exposed to far-red light (wavelength of about 730 nanometers), the protein activateda genetic pathway that causedthe cells to produce insulin.

After that success, they team made dime-sizedevices in which circular power-receiving coils surround a hydrogel that is embedded with the engineered cells and far-red LEDs. These devices were implanted under the skin of diabetic mice. When an external transmitting coil wirelessly switches on the LEDs via electromagnetic induction, their light triggers the cells to produce insulin in the animals.

The team made three things to remotely control the engineered cells: a custom-engineered Bluetooth-active glucometer,an Android-based smartphone app,and an intelligent control box that controls the power-transmitting coil.

When the researchers placemice blood samples on the glucometer, it sends measurements to the smartphone via Bluetooth. The phone app compares these levels to a pre-set threshold, then signals the control box to turn on the power-transmitter coil, which switches on the LEDs long enough for the cell implant to deliver the right amount of insulin.

The animals blood glucose typically went down to nondiabetic levels within two hours of irradiation. The system maintained the blood glucose concentration in mice for 15 days without any side effects. After that it could be replaced, Ye says, but a much longer performance or replacement frequency of the implant needs to be further investigated in humans.

One big limitation of the system is that it needs manual blood draws. Another is that the animals need to be close to the transmitting coil and be exposed to EM radiation to switch on the LEDs.

But a bit more engineering could yielda diabetesmonitoring-and-treatment system that isfully automatic and portable. A continuous glucose monitorcould send blood sugar measurements to the users phone. The phone would trigger a battery-powered LED wristband to shine light on the implanted insulin-producing cells.

IEEE Spectrums biomedical engineering blog, featuring the wearable sensors, big data analytics, and implanted devices that enable new ventures in personalized medicine.

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Smartphone-Controlled Cells Keep Diabetes In Check - IEEE ... - IEEE Spectrum

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Type 1 Diabetes Mellitus Forecast in 12 Major Markets 2017-2027 … – Yahoo Finance

Posted: April 27, 2017 at 10:43 am

DUBLIN--(BUSINESS WIRE)--

Research and Markets has announced the addition of the "Type 1 Diabetes Mellitus Forecast in 12 Major Markets 2017-2027" report to their offering.

Type 1 Diabetes Mellitus (T1DM) is a multisystem disease that progressively destroys the pancreas' ability to produce insulin. This leads to a chronic condition of defective metabolism of fat, carbohydrates and proteins due to the lack of insulin. It occurs mainly in childhood and adolescents, however a rising number of latent autoimmune diabetes of adulthood (LADA) cases have been reported mainly due to a better understanding and diagnosis of the disease.

This report provides the current prevalent population for Type 1 Diabetes Mellitus across 12 Major Markets (USA, Canada, France, Germany, Italy, Spain, UK, Brazil, Japan, India, China and Russia) split by gender and 5-year age cohort. Along with the current prevalence, the report also contains a disease overview of the risk factors, disease diagnosis and prognosis along with specific variations by geography and ethnicity.

Providing a value-added level of insight from the analysis team, several of the main symptoms and co-morbidities of Type 1 Diabetes Mellitus have been quantified and presented alongside the overall prevalence figures. These sub-populations within the main disease are also included at a country level across the 10-year forecast snapshot.

Reasons to Buy:

- Able to quantify patient populations in global Type 1 Diabetes Mellitus market to target the development of future products, pricing strategies and launch plans.

- Gain further insight into the prevalence of the subdivided types of Type 1 Diabetes Mellitus and identify patient segments with high potential.

- Delivery of more accurate information for clinical trials in study sizing and realistic patient recruitment for various countries.

- Provide a level of understanding on the impact from specific co-morbid conditions on Type 1 Diabetes Mellitus prevalent population.

- Identify sub-populations within Type 1 Diabetes Mellitus which require treatment.

- Gain an understanding of the specific markets that have the largest number of Type 1 Diabetes Mellitus patients.

Key Topics Covered:

1. Introduction

2. Cause of the Disease

3. Risk Factors & Prevention

4. Diagnosis of the Disease

5. Variation by Geography/Ethnicity

6. Disease Prognosis & Clinical Course

7. Key Comorbid Conditions/Features associated with the disease

8. Methodology for quantification of patient numbers

9. Top-line Prevalence for Type 1 Diabetes Mellitus

10. Features of Type 1 Diabetes Mellitus Patients

10.1 Comorbidities and Sequelae in T1DM Patients

10.2 T1DM patients with Retinopathy

10.3 Prevalence of T1DM defining antibodies

11. Abbreviations used in the report

12. Patient-Based Offering

13. Online Pricing Data and Platforms

14. References

15. Appendix

For more information about this report visit http://www.researchandmarkets.com/research/j3bqpv/type_1_diabetes

View source version on businesswire.com: http://www.businesswire.com/news/home/20170427005670/en/

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Type 1 Diabetes Mellitus Forecast in 12 Major Markets 2017-2027 ... - Yahoo Finance

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