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Closing the Diabetes Disparities Gap – Huffington Post

Posted: May 1, 2017 at 4:40 am

When it comes to diabetes in the United States, minority populations are hardest hit.

African Americans and Hispanics are almost twice as likely as non-Hispanic whites to be diagnosed with diabetes by a physician, according to the U.S. Department of Health and Human Services Office of Minority Health and national examination surveys. African American and Hispanic Americans have higher rates of end-stage renal disease (ESRD) caused by diabetes and start ESRD treatment 2.4 and 1.6 times more often, respectively, compared with non-Hispanic whites.

Income, stable and affordable housing, access to healthy food, quality education and a host of other factors influence a person's health status and longevity. These factors, what public health professionals recognize as social determinants of health, contribute to higher rates of diabetes and associated illness in African American and Hispanic American communities.

During National Minority Health Month each April, the U.S. Department of Health and Human Services Office of Minority Health (OMH) leads the nation in raising awareness about these disparities, their causes and the impact they have on minority communities and the nation as a whole.

The theme of this years National Minority Health Month observance Bridging Health Equity Across Communities, emphasizes the collaborative, community-level work being done across the

nation to help achieve health equity. Dannons partnership with WIC and Lenox Hill Hospitals partnership with leading health providers are two examples of collaborative efforts to bridge the health equity gap.

One way Dannon is helping to achieve health in minorities is by working to make healthier food choices readily available to WIC participants. The addition of yogurt to the WIC food packages, which began on April 1, 2015, brings important nutrients to pregnant women, breastfeeding mothers and young children at critical life stages.

Yogurt is especially well suited for the WIC audience. Most yogurts provide three out of the four nutrients of concern -- calcium, potassium and vitamin D -- and eating yogurt regularly is associated with less weight gain over time. Overweight and obesity are two major risk factors for diabetes. Yogurt is also a source of high quality protein, which can help support bone and muscle strength, and most yogurts contain live and active cultures that help with lactose digestion.

Dannon offers a variety of WIC eligible products to meet WIC participants needs and preferences which can be found here.

Lenox Hill Hospital Partnership

The Gerald J. Friedman Diabetes Institute at Lenox Hill Hospital in New York along with a coalition of other leading health care providers, government officials, public- and private-sector companies, and community-based organizations, recently pledge to help build a sustainable path to health and wellness for the thousands of New Yorkers living with diabetes.

The coalitions new program Vida SI, Diabetes NO! (Life YES! Diabetes NO!), is a bilingual, long-term health initiative that will take a comprehensive and systematic look at diabetes among Latinos with the goal of uncovering the root causes, leading to more effective and efficient delivery of prevention, education, testing, and treatment.

Participants of Vida SI, Diabetes NO! (Life YES! Diabetes NO!) have access to bi-lingual diabetes educators, nutritionists, social workers, exercise trainers and other diabetes specialists to help improve the management of their diabetes and help them live longer healthier lives.

You can learn more about Vida SI, Diabetes NO! (Life YES, Diabetes NO!) on social media including Facebook https://www.facebook.com/VidaSIDiabetesNO on https://twitter.com/VSIDNO and on Instagram under user name @vsidno.

Dannons partnership with WIC and Lenox Hills Vida SI, Diabetes NO! (Life YES! Diabetes NO!) program are national and community level partnerships that will help close the diabetes disparities gap in African Americans and Hispanics.

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Diabetes, weight gain can alter your brain, says study – WLWT Cincinnati

Posted: May 1, 2017 at 4:40 am

(CNN)

It's well-known that type 2 diabetes can cause medical complications in certain organs, including the brain. But overweight and obese people with early-stage type 2 diabetes have more severe abnormalities in brain structure and cognition than normal-weight people with type 2 diabetes, according to a new study in Diabetologia, the journal of the European Association for the Study of Diabetes.

Having type 2 diabetes and being overweight, then, can combine to have a greater effect on brain structures.

"There's a general agreement that type 2 diabetes is a risk factor for various types of both structural and functional abnormalities in the brain," said Dr. Donald C. Simonson, a co-author of the study and an endocrinologist specializing in diabetes. "Simple obesity also shows the same type of abnormalities ... in a milder stage. You can see where it's not quite exactly normal but not quite as bad as someone with diabetes.

"So, if you have both, will it be worse than if you have them alone? That's what we looked at in this particular study," said Simonson, who teaches at Harvard's T.H. Chan School of Public Health.

Dr. In Kyoon Lyoo, lead author and a professor at the Ewha Brain Institute at Ewha Womens University in Seoul, South Korea, wrote in an email, "As obesity has been known to be associated with metabolic dysfunction, inflammation, and brain changes independently of diabetes, we expected that brain alterations might be more pronounced in overweight/obese participants with type 2 diabetes."

Effects on the brain

Lyoo, Simonson and their colleagues designed a study around 50 overweight or obese people age 30 to 60 who had been diagnosed with type 2 diabetes.

Fifty normal-weight people diagnosed with type 2 diabetes and 50 normal-weight people without diabetes also participated. These additional participants were age and sex matched to the original group. Those diagnosed with diabetes were also matched for disease duration. Standard body mass index ranges defined "overweight" (having a BMI of 25 to 29.9), "obese" (greater than 30) and "normal weight" (18.5 to 25).

The researchers used magnetic resonance imaging to examine each participant's brain structure, including the thickness of the cerebral cortex and white matter connectivity. Gray matter in the brain contains the neuron cell bodies, whereas white matter contains bundles of nerve fibers and its job is to process and send signals along the spinal cord.

The researchers chose to study thickness and connectivity "because these could be sensitive markers of diabetes-related brain changes, and could be reliably quantified by using magnetic resonance imaging," Lyoo explained.

Participants also were tested for memory, psychomotor speed and executive function, since these are known to be affected in people with type 2 diabetes.

The results aligned with the researchers' initial assumptions, Lyoo said.

Clusters of gray matter were significantly thinner in the temporal, prefrontoparietal, motor and occipital cortices in the brains of diabetic participants than in the non-diabetic group, the study found. More thinning of the temporal and motor cortices could be seen in the overweight/obese diabetic group compared with normal-weight diabetics. Separately and collectively, these areas of the brain impact motor control, executive function, body awareness, concentration and other cognitive functions.

"Most of the things we looked at, you could see that there was a progression, and the obese patients with diabetes were worse than the lean patients with diabetes, and they were both worse than the age-matched controls," Simonson said.

In particular, the temporal lobe appears vulnerable to the combined effects of type 2 diabetes and being overweight or obese, the researchers say. The temporal lobe is implicated in language comprehension and long-term memory.

The brain has been the last frontier in the study of complications of diabetes, Simonson said.

Similarities to Alzheimer's disease

"Diabetic retinopathy, eye disease, is reasonably well-understood," he said. "The same is true of kidney disease, amputations -- we understand much better what causes them and how to prevent them.

"But the brain has been the proverbial black box. It's incredibly complicated, and you can't directly study it. You can't go in and take samples," he said. "The last several years, the techniques of MRI got good enough that we could really look carefully at the brain."

Most of the initial work in the very late 1990s was done in Alzheimer's, schizophrenia, depression and other classic psychiatric diseases, but then scientists began to look at other diseases including diabetes, explained Simonson. At this point, researchers around the world began to see connections.

"You can see a person with depression has thinning of the surface of the brain in certain areas, and you go in and do the same study with somebody with diabetes, and they have thinning in the exact same areas," Simonson said. And diabetes may be a predisposing or risk factor for developing Alzheimer's, he said.

"You see the same types of abnormalities in a milder form in the brain in people with diabetes that you see in people with Alzheimer's disease," Simonson said.

According to Dr. William T. Cefalu, chief scientific, medical and mission officer of the American Diabetes Association, the study is consistent with previous research.

"The presence of overweight and obesity have been shown in other studies to be associated with early structural changes in the brain, and may contribute to cognitive issues," said Cefalu, who was not involved in the new study. "The current study implies that obesity/overweight status in individuals with diabetes may also contribute."

That said, longer-term and more definitive studies are needed to evaluate that aspect.

In the end, Simonson said, another question is more important: "What can you do to prevent it? That's the big question."

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Diabetes, weight gain can alter your brain, says study - WLWT Cincinnati

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UMD loses student athlete to diabetes-related complications – SouthCoastToday.com

Posted: May 1, 2017 at 4:40 am

Aimee Chiavaroli achiavaroli@s-t.com

UMASS DARTMOUTH A UMass Dartmouth male student and lacrosse player died Saturday due to complications related to Type 1 Diabetes, according to a news release.

Sean Peters was a Crime and Justice major and four-year member of the mens lacrosse team, according to the universitys athletics website. He was 22 years old and went to UMass Dartmouth from Medway High School.

Our hearts are broken by Seans passing, Interim Chancellor Peyton R. Helm wrote to students, faculty, and staff Saturday. There are no words that can adequately express the profound loss being felt today by his family, friends, teammates, and classmates. All we can do is hold close those who loved Sean and support them in the difficult days ahead.

We are deeply saddened by the loss of Sean, said Amanda Van Voorhis, athletic director, in a statement. Sean was a four-year letter winner for the Corsairs, and was in the midst of the most prolific season of his career. He had just been recognized on Senior Day last Saturday. This is incomprehensible and a tremendous loss for our athletic community. The UMass Dartmouth Athletics family extends our condolences to the Peters family and loved ones.

According to the news release, Peters was the epitome of a Corsair who balanced the challenging demands of being a student and an athlete.

Peters appeared in 49 career games, starting 24 and all 13 of his contests during his senior campaign. This year, he had 23 goals and 14 assists for 37 points. He registered four goals in a game twice this season, including a career-high seven-point performance in UMass Dartmouths 19-5 win over Becker College April 10. In his final game April 22, he tallied two goals and two assists versus Western Connecticut State University in a 14-8 win, according to the university.

"We encourage friends, teammates, and community members who were close to Sean, and there were many, to come together to support each other and his family at this most difficult time, said David Milstone, associate vice chancellor for student affairs, in a statement. We will ask the family if they are amenable to holding a campus memorial. Our counseling staff is available to meet with members of the community as individuals or as groups."

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Advent France Biotechnology Holds First Close of Biotechnology Fund I, at 64.75M – FinSMEs (blog)

Posted: April 29, 2017 at 5:51 pm


FinSMEs (blog)
Advent France Biotechnology Holds First Close of Biotechnology Fund I, at 64.75M
FinSMEs (blog)
Paris, France based Advent France Biotechnology has held the first close of Advent France Biotechnology Seed-Fund I, at 64.75m (USD68.5m). Supported in by the National Seed-Fund (Fonds National d'Amorage) managed by Bpifrance under the ...

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How Yogurt Science Could Lead To A Cure For Sickle Cell Anemia – WBUR

Posted: April 29, 2017 at 5:50 pm

wbur Commentary

April 28, 2017

By Dr. Julie Losman

Dr. Julie Losman, a physician-scientist at Dana-Farber Cancer Institute and Brigham and Womens Hospital, told a memorable tale of sickle cell anemia and science at a Harvard rally before Boston's March for Science. It echoed a common theme, that support for basic science is crucial because it's not clear where the next great cure will come from. Her speech, lightly edited:

Sickle cell anemia has a very special place in the history of medicine: It was the first human disease that was understood on a molecular level.

Sickle cell anemia is caused by a single mutation in a gene, the hemoglobin gene, that produces a mutant protein with an abnormal structure. This abnormal hemoglobin disrupts the function of red blood cells.

The mutation was discovered in 1949 by a scientist named Linus Pauling. Pauling was not a medical doctor. He was a chemical engineer, a basic scientist. In fact, he won the Nobel Prize in 1954 for helping to invent the field of quantum chemistry, which is the study of how atoms and molecules interact. He was as fundamental and "basic" a scientist as you can be.

And yet it was Pauling's work on how small molecules bond together that led him to study how very big molecules, like proteins, bond together. This, in turn, led him to try and understand how a mutation in a gene could change the structure of a protein and alter the way that the protein bonds to other proteins.

That is how a chemical engineer who began his career studying protons and electrons made the first discovery of a human disease caused by a specific mutation.

The importance of this discovery to modern medicine cannot be overstated. Linus Paulings work laid the foundation for the entire field of medical genetics, which has absolutely revolutionized how we think about human disease.

For many, many, years, and even today, for many, many patients, the treatment for sickle cell anemia is palliative: Avoid things that trigger pain crises, treat pain crises when they happen, and try to protect organs from the damage that a crisis can cause. That is basically it.

A very few people with sickle cell anemia have successfully been cured with a transplant. Stem cell transplants are complicated, dangerous and very, very expensive. Undergoing a stem cell transplant requires absolute dedication from the patient, their families, their friends, their communities and their medical teams. Unfortunately, not everyone with sickle cell anemia has that kind of support or the access to exceptional medical care. A stem cell transplant for them is simply not an option.

But there is basic research going on right now --here in Boston and in labs across the United States and around the world --that has the potential to revolutionize how we treat sickle cell anemia. Right now, scientists are working on how to use an extraordinary new discovery called CRISPR to fix genetic mutations like the mutation that causes sickle cell anemia.

When this technique is perfected --not if it is perfected, but when it is perfected --it will be possible to take the stem cells of a patient, correct their mutation, and give them back their own stem cells. Because these reinfused stem cells would be perfectly at home in the patients body, there would be no need for months and months of post-transplant recovery.

Instead of being a leap of faith, a transplant would be a simple and safe procedure. It could even be done in young children with sickle cell anemia, before they ever have their first excruciating pain crisis.

The discovery of CRISPR and gene editing was not made by a geneticist or a stem cell biologist. CRISPR was discovered by a bunch of microbiologists, scientists who study bacteria and viruses.

In fact, much of the foundational work in CRISPR was done by nutritional microbiologists who wanted to understand how the bacteria we use to make cheese and yogurt are able to fight off viral infections. Imagine that! The future of gene therapy began in a yogurt vat.

The lesson we need to take away from Linus Pauling and these yogurt scientists is that basic fundamental research --the kind of research that is being done not just by the National Institutes of Health, but also by the National Science Foundation, the Department of Energy, NASA, the Environmental Protection Agency, the Department of Defense --is all absolutely crucial to advancing human health.

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AJ Foyt undergoes stem cell therapy, toe surgery – USA TODAY

Posted: April 29, 2017 at 5:50 pm


USA TODAY
AJ Foyt undergoes stem cell therapy, toe surgery
USA TODAY
Foyt, whose list of injuries is almost as long as that of his legendary racing achievements, had right foot toe surgery Wednesday just days after stem cell therapy in Mexico. So the winner of Phoenix Raceway's debut event in 1964 won't be at ...

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AJ Foyt undergoes stem cell therapy, toe surgery - USA TODAY

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Stem cell therapy treats man with muscle degeneration – Zee News

Posted: April 29, 2017 at 5:50 pm

New Delhi: A 20-year-old man named Aditya Bhatia was suffering from Facioscapulohumeral Muscular Dystrophy (FSHD) -- a condition which slowly weakens and degenerates all the muscles of the body leading to disability was treated using stem cell therapy.

Aditya was diagnosed with Facioscapulohumeral Muscular Dystrophy (FSHD) in 2012. It started after he found it difficult to lift his arms over the head -- one of the main and strongest symptoms. Consultations with several doctors did not find Bhatia any solution, and his condition grew severe and started affecting other parts of the body such as face.

FSHD usually begins before age 20, with weakness and atrophy of the muscles around the eyes and mouth, shoulders, upper arms and lower legs. Later, weakness can spread to abdominal muscles and sometimes hip muscles.

Experts says that FSHD can be divided into adult-onset and infantile-onset forms.

Bhatia's parents had heard about the stem cell treatment which had proved effective in many diseases such as spinal diseases.

Accordingly, they consulted doctors on stem cell therapy and decided to give it a try.

All the procedures were followed and he was tested for hyper sensitivity reactions with stem cells, also known as Human Embryonic Stem Cell Therapy.

Doctors said that during the treatment procedure, Bhatia was injected with 0.05 ml stem cells.

(With IANS inputs)

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Diabetes, weight gain can alter your brain, says study – WYFF Greenville

Posted: April 29, 2017 at 5:49 pm

(CNN)

It's well-known that type 2 diabetes can cause medical complications in certain organs, including the brain. But overweight and obese people with early-stage type 2 diabetes have more severe abnormalities in brain structure and cognition than normal-weight people with type 2 diabetes, according to a new study in Diabetologia, the journal of the European Association for the Study of Diabetes.

Having type 2 diabetes and being overweight, then, can combine to have a greater effect on brain structures.

"There's a general agreement that type 2 diabetes is a risk factor for various types of both structural and functional abnormalities in the brain," said Dr. Donald C. Simonson, a co-author of the study and an endocrinologist specializing in diabetes. "Simple obesity also shows the same type of abnormalities ... in a milder stage. You can see where it's not quite exactly normal but not quite as bad as someone with diabetes.

"So, if you have both, will it be worse than if you have them alone? That's what we looked at in this particular study," said Simonson, who teaches at Harvard's T.H. Chan School of Public Health.

Dr. In Kyoon Lyoo, lead author and a professor at the Ewha Brain Institute at Ewha Womens University in Seoul, South Korea, wrote in an email, "As obesity has been known to be associated with metabolic dysfunction, inflammation, and brain changes independently of diabetes, we expected that brain alterations might be more pronounced in overweight/obese participants with type 2 diabetes."

Effects on the brain

Lyoo, Simonson and their colleagues designed a study around 50 overweight or obese people age 30 to 60 who had been diagnosed with type 2 diabetes.

Fifty normal-weight people diagnosed with type 2 diabetes and 50 normal-weight people without diabetes also participated. These additional participants were age and sex matched to the original group. Those diagnosed with diabetes were also matched for disease duration. Standard body mass index ranges defined "overweight" (having a BMI of 25 to 29.9), "obese" (greater than 30) and "normal weight" (18.5 to 25).

The researchers used magnetic resonance imaging to examine each participant's brain structure, including the thickness of the cerebral cortex and white matter connectivity. Gray matter in the brain contains the neuron cell bodies, whereas white matter contains bundles of nerve fibers and its job is to process and send signals along the spinal cord.

The researchers chose to study thickness and connectivity "because these could be sensitive markers of diabetes-related brain changes, and could be reliably quantified by using magnetic resonance imaging," Lyoo explained.

Participants also were tested for memory, psychomotor speed and executive function, since these are known to be affected in people with type 2 diabetes.

The results aligned with the researchers' initial assumptions, Lyoo said.

Clusters of gray matter were significantly thinner in the temporal, prefrontoparietal, motor and occipital cortices in the brains of diabetic participants than in the non-diabetic group, the study found. More thinning of the temporal and motor cortices could be seen in the overweight/obese diabetic group compared with normal-weight diabetics. Separately and collectively, these areas of the brain impact motor control, executive function, body awareness, concentration and other cognitive functions.

"Most of the things we looked at, you could see that there was a progression, and the obese patients with diabetes were worse than the lean patients with diabetes, and they were both worse than the age-matched controls," Simonson said.

In particular, the temporal lobe appears vulnerable to the combined effects of type 2 diabetes and being overweight or obese, the researchers say. The temporal lobe is implicated in language comprehension and long-term memory.

The brain has been the last frontier in the study of complications of diabetes, Simonson said.

Similarities to Alzheimer's disease

"Diabetic retinopathy, eye disease, is reasonably well-understood," he said. "The same is true of kidney disease, amputations -- we understand much better what causes them and how to prevent them.

"But the brain has been the proverbial black box. It's incredibly complicated, and you can't directly study it. You can't go in and take samples," he said. "The last several years, the techniques of MRI got good enough that we could really look carefully at the brain."

Most of the initial work in the very late 1990s was done in Alzheimer's, schizophrenia, depression and other classic psychiatric diseases, but then scientists began to look at other diseases including diabetes, explained Simonson. At this point, researchers around the world began to see connections.

"You can see a person with depression has thinning of the surface of the brain in certain areas, and you go in and do the same study with somebody with diabetes, and they have thinning in the exact same areas," Simonson said. And diabetes may be a predisposing or risk factor for developing Alzheimer's, he said.

"You see the same types of abnormalities in a milder form in the brain in people with diabetes that you see in people with Alzheimer's disease," Simonson said.

According to Dr. William T. Cefalu, chief scientific, medical and mission officer of the American Diabetes Association, the study is consistent with previous research.

"The presence of overweight and obesity have been shown in other studies to be associated with early structural changes in the brain, and may contribute to cognitive issues," said Cefalu, who was not involved in the new study. "The current study implies that obesity/overweight status in individuals with diabetes may also contribute."

That said, longer-term and more definitive studies are needed to evaluate that aspect.

In the end, Simonson said, another question is more important: "What can you do to prevent it? That's the big question."

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Messy litter box could mean diabetes for indoor cats – Palm Beach Post

Posted: April 29, 2017 at 5:49 pm

Question: My cat is suddenly making a mess in his litter box. It is full of pee spots and really large-sized ones. He used to only pee in one small spot a day; now it is several large spots.

He acts fine and is eating good. He has always been a chunky cat, but I think he has lost a little weight recently.

Answer: I am glad that you are monitoring your kittys litter box so well. It is important to know what is normal for your cat. Most cats only urinate once or twice a day. When the amount in the litter box suddenly increases, it is a good indication that there is a problem. Please monitor his water and food intake as well. He is probably drinking a good bit more water.

Your kitty will need a trip to his veterinarian to check a urine sample and do a thorough physical examination. Many times, blood testing will be necessary to fully diagnose the problem. Things that can cause increased urination are: diabetes, kidney disease, infection, tumor, crystals or stones in the bladder, and thyroid disease. All of these can be serious, if left untreated.

Diabetes is most often seen in indoor cats that are overweight. The sooner they are diagnosed and treated, the better they tend to do. Diabetes occurs when blood sugar levels get too high and the body cannot utilize it. Insulin is needed to help absorb blood sugar and get nutrition to the cells that need it. When too much glucose (sugar) is in the bloodstream, it is flushed out in the urine and takes excess water with it this causes your cat to drink larger amounts of water and urinate at larger volumes. Diabetes in cats can be treated with insulin injections and a special diet high in protein, with little or no carbohydrates.

Cats are true carnivores, so too much carbohydrates in the diet are not tolerated well. Diabetes in cats can be reversed if caught quickly, however, changes must be made to control blood sugar, weight and diet.

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Extension offering free diabetes education – WJBC News

Posted: April 29, 2017 at 5:49 pm

The local University of Illinois Extension is giving people a chance to become more educated about diabetes. (WJBC File Photo)

By Cynthia Grau/WJEZ News

EUREKA The local University of Illinois Extension is providing information to get a handle on diabetes.

The Extension is offering I on Diabetes, a four-part series beginning May 1 in Eureka.

Jenna Smith, nutrition and wellness educator and registered dietician for the Extension, explained how the class works.

It is really designed to help you manage diabetes, and if you dont have diabetes, its really a good program to help you think about ways to prevent diabetes, because no one wants that. Its a great program that usually costs money, and this year, it is absolutely free, because we got a grant. So Im super excited about that, Smith said.

To register, call 309-467-3789 or visit go.illinois.edu/lmw.

Cynthia Grau can be reached at cynthia.grau@cumulus.com

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