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Group medical visits key with managing diabetes – Williamsburg Yorktown Daily

Posted: April 2, 2017 at 4:43 am

WYDaily.com is your source for free news and information in Williamsburg, James City & York Counties.

Healthier lifestyles, including regular exercise and better eating habits are all goals most diabetes patients are striving for.

Kendra Robinson, a certified diabetes educator at Old Towne, believes these goals, plus learning from each other in a group setting is essential in managing the disease.

At Old Towne Medical Center, group medical visits are an option for patients with Type 2 diabetes a program that has been successful for the past eight years.

Robinson follows 400 diabetes patients, and said those who do group visitswhich include four to five patientshave better outcomes than those who are seen individually by doctors.

These patients tend to follow through more than patients we are seeing one on one, Robinson said.

During group visits, doctors and nurses give patients information about medications and nutrition, but the patients learn how to manage the disease from each other, Robinson added.

Ultimately, diabetes is a disease that is self-managed, Robinson said. Lifestyle modification is the number one treatment.

Type 2 diabetes, distinct from type 1 diabeteswhich is caused by genetic mutations or virusesoften develops from lifestyle factors, namely obesity.

March 28th marked the American Diabetes Association (ADA)s nation-wide Alert Day, in which it invites all Americans to take a diabetes risk test on its web site: http://www.diabetes.org/are-you-at-risk/diabetes-risk-test/?loc=alertday

According to the ADA, the biggest risk factor for diabetes is becoming overweight by overeating.

Not surprisingly, dietary changes are the biggest obstacle diabetics need to overcome, Robinson added. Access to healthy food is a challenge. Changing age-old eating habits is very difficult.

With that in mind, Old Towne also offers cooking classes and grocery store tours for diabetes patients.

During the classes, they make healthy meals, and then send everyone home with a bag of groceries and healthy recipes. They also go to the grocery stores where patients are most likely to shop.

We teach them how to get the most bang for buck; read a food label; use a coupon, Robinson said.

Its a big hit because at the end of the tour, everyone gets a little gift card to buy some things they learned about on the tour that they never tried before.

This spring Old Towne plans to launch an eat out program, which will target older men who are either widowed or single and tend to eat out a lot.

The idea is to go to the restaurants where they regularly eat and help them select healthy food items.

Old Towne also has a medications assistance program that provides diabetes medications for free, Robinson said, and the Sentara Williamsburg Regional Medical Center provides discounted rates for diabetes-related testing.

This financial help is significant because diabetes can be an expensive disease to manage. At Old Towne 76 percent of patients are uninsureda number that is rising, according to Janis C.L. MacQueston, Old Towne Director of Development.

The patient population also tends to be fairly transient. Of the 400 diabetes patients that Robinson follows, between 250 and 300 come regularly, meaning every three to six months.

For those who stick around for a while, control is pretty good, Robinson said.

But the attrition rate is high, and they constantly get new patientsespecially young adults who were obese in childhood and carried that into adulthood, she continued.

According to the Virginia Atlas of Community Health, six percent of the population over age 19 in Williamsburg has type 2 diabetes, and 25 percent of the population between the ages of 14 and 19. In James City County, ten percent of the adult population has diabetes, and 37 percent of teenagers.

Many patients test for diabetesat one of Old Townes free walk-in clinicswhen they already have tell-tale signs of the disease, like blurry vision or frequent sweating, Robinson said.

We check their blood sugar, and its off the charts, she added.

Another program in Williamsburg at the Peninsula YMCA called the Diabetes Prevention Program tries to help people before they even get to that point. It enrolls people with prediabetes, which can morph into diabetes, usually within five years, if left untreated.

The program is nationwide, has beenimplemented in 252 YMCAs throughout the U.S., and follows CDC guidelines, saidMichael Bennett, the regional director of operations and chronic diseases at the Peninsula YMCA.

Bennett said theyve enrolled 32 people locally.

So far weve had really good stories, he said. The facilitator gives them tools, and the participants help each other out. They become a support system for each other.

The goal is for people to lose five to seven percent of their body weight, and engage in 150 minutes of physical activity each week.

The Williamsburg Health Foundation gave the YMCA a $45,000 grant to sign up 75 new people by the end of the year, Bennett said.

Were trying to encourage people to nip it in the bud, he said.

For more information on the YMCA program, people can call 757-342-5338, or visit the YMCA web site: http://www.peninsulaymca.org/diabetes/.

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Drink This to Stop a Drastic Blood Sugar Spike – Men’s Health

Posted: April 2, 2017 at 4:43 am


Men's Health
Drink This to Stop a Drastic Blood Sugar Spike
Men's Health
The glucose builds up in your blood, which can lead to prediabetes or diabetes. But consuming the black tea polyphenols seems to reduce the blood sugar spike you'd normally experience after drinking something sugary. That may be because the black tea ...

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‘U’ Needs Type 2 Diabetes Sufferers For GRADE Study – CBS Minnesota / WCCO

Posted: April 2, 2017 at 4:43 am

April 1, 2017 11:04 PM By Susan-Elizabeth Littlefield

MINNEAPOLIS (WCCO) Good news for some locals who suffer from a common chronic disease.

Diabetes patients can get free medicine and more care as part of a University of Minnesota research study.

Doctors are trying to figure out which medication combinations best fight Type 2 Diabetes.

Its called GRADE: Glycemia Reduction Approach to Diabetes: Effectiveness Study.

Participants meet with entire teams of experts monthly. Hugo resident Larry Bock is a participant of the program. He has lost 90 pounds since enrolling and has his blood sugar under control.

My journey with the GRADE study has been nothing short of amazing, Bock said. The study has not only taught me how to manage my diabetes, but has taught me to manage a life style living with diabetes. I hope the GRADE study will be embraced by others wanting to make a change.

Dr. Betsy Seaquist is behind the program.

Im very excited about this study because it will really change clinical practice, and it is wonderful seeing all of these people enrolling in this study losing weight, getting their blood sugars down to normal and remaining that way for years, Seaquist said. Its a very exciting thing to do.

Click here for more information on the GRADE study.

Susan-Elizabeth Littlefield never imagined she'd be in the Twin Cities, but this is exactly where she says she wants to be. She says in her travels as a journalist, one common denominator was that she always really liked the people she met from...

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Legumes may lower risk of type 2 diabetes – Medical News Today

Posted: April 2, 2017 at 4:43 am

Type 2 diabetes is a serious health concern in the United States and across the globe. New research shows that a high consumption of legumes significantly reduces the risk of developing the disease.

The legume family consists of plants such as alfalfa, clover, peas, peanuts, soybeans, chickpeas, lentils, and various types of beans.

As a food group, they are believed to be particularly nutritious and healthful. One of the reasons for this is that they contain a high level of B vitamins, which help the body to make energy and regulate its metabolism.

Additionally, legumes are high in fiber and contain minerals such as calcium, magnesium, and potassium. They also comprise a variety of so-called phytochemicals - bioactive compounds that further improve the body's metabolism and have been suggested to protect against heart disease and diabetes.

Finally, legumes are also considered to be a "low glycemic index food," which means that blood sugar levels increase very slowly after they are consumed.

To make people aware of the many health benefits of legumes, the year 2016 has been declared the International Year of Pulses by the Food and Agriculture Organization of the United Nations. Pulses are a subgroup of legumes.

Because of their various health benefits, it has been suggested that legumes protect against the onset of type 2 diabetes - a serious illness that affects around 29 million people in the U.S. and more than 400 million adults worldwide. However, little research has been carried out to test this hypothesis.

Therefore, researchers from the Unit of Human Nutrition at the Universitat Rovira i Virgili in Tarragona, Spain, together with other investigators from the Prevencin con Dieta Mediterrnea (PREDIMED) study, set out to investigate the association between legume consumption and the risk of developing type 2 diabetes in people at an increased risk of cardiovascular disease.

The study also analyzes the effects of substituting legumes with other foods rich in proteins and carbohydrates, and the findings were published in the journal Clinical Nutrition.

The team investigated 3,349 participants in the PREDIMED study who did not have type 2 diabetes at the beginning of the study. The researchers collected information on their diets at the start of the study and every year throughout the median follow-up period of 4.3 years.

Individuals with a lower cumulative consumption of legumes had approximately 1.5 weekly servings of 60 grams of raw legumes, or 12.73 grams per day. A higher legume consumption was defined as 28.75 daily grams of legumes, or the equivalent of 3.35 servings per week.

Using Cox regression models, the researchers analyzed the association between the incidence of type 2 diabetes and the average consumption of legumes such as lentils, chickpeas, dry beans, and fresh peas.

Overall, during the follow-up period, the team identified 266 new cases of type 2 diabetes.

The study revealed that those with a higher intake of legumes were 35 percent less likely to develop type 2 diabetes than their counterparts who consumed a smaller amount of legumes. Of all the legumes studied, lentils had the strongest association with a low risk of type 2 diabetes.

In fact, individuals with a high consumption of lentils (defined as almost one weekly serving) were 33 percent less likely to develop diabetes compared with their low-consumption counterparts - that is, the participants who had less than half a serving per week.

Additionally, the researchers found that replacing half a serving per day of legumes with an equivalent portion of protein- and carbohydrate-rich foods including bread, eggs, rice, or potatoes also correlated with a reduced risk of diabetes.

The authors conclude that:

"A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk."

Learn how a healthful vegetarian diet could substantially reduce type 2 diabetes risk.

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Cone Health clinic fights diabetes in Rockingham County – Greensboro News & Record

Posted: April 2, 2017 at 4:43 am

REIDSVILLE Since Fall 2015, the Cone Health Nutrition and Diabetes Management Center in Reidsville has been tackling diabetes head on as the first clinic of its kind in Rockingham County.

We provide education to patients that have diabetes and other medical problems, said Penny Crumpton, registered dietician and certified diabetes educator with the center. Our goal is to try to help provide knowledge and education to those who need assistance in helping improve their diabetes and reducing the complications that we know diabetes can cause.

According to Crumpton, diabetes is a serious issue in Rockingham County.

The rates of diabetes are extremely high in Rockingham County so the need is very great in terms of reaching out to those who are most in need, Crumpton said. While we educate patients with diabetes, we also try to reach out and address the epidemic of pre-diabetes that certainly puts patients at high risk for developing diabetes down the road.

Uncontrolled diabetes can lead to long time and irreversible problems, including damage to the eyes and kidneys, cardiovascular complications and peripheral vascular disease.

In the year and a half since the center opened, Crumpton and Gebre Nida, the centers endocrinologist, have been working with patients to help address those problems.

At the office, patients can come for one-on-one counseling sessions to discuss their situation or guests can attend free community education classes at 9 a.m. on the first and third Monday of the month at Annie Penn Hospital.

Yet with diabetes a prevalent problem in the area, Crumpton and Nida are pushing for awareness through the diabetes task force. This task force unites local health care providers and other community stakeholders around making a change.

Were working through the diabetes task force to try to increase the public awareness of the rates of diabetes and getting the resources more visible to the community and being able to connect patients with resources, Crumpton said.

For Norbert Hector, the center has already made a difference in his life after visiting the center for the first time in February.

According to Hector, he was diagnosed with diabetes about 20 years ago and has been on insulin for about 11 years.

About two months ago, my readings became very erratic, and so I called (my primary care provider) and tried to do some self-adjusting and really messed it up, he said.

His doctor referred him to Nida at the Cone Health Nutrition and Diabetes Management Center in Reidsville.

As a diabetic, I had been concerned about it, Hector said. I know its a progressive disease, and Ive watched other diabetics including my brother get progressively worse and my brother eventually died.

By following the directions given to him by Nida and Crumpton and with the support of his wife, Hector has already seen improvements in his condition.

I feel a lot more optimistic now than I did two months ago, he said.

As the center creates more stories like Hectors and the practice builds, they will consider adding another endocrinologist and diabetes educator to widen the centers impact and reach the growing population affected by diabetes.

For more information about the Cone Health Nutrition and Diabetes Management Center in Reidsville, call 336-951-6070 or visit the center at 1107 S. Main St., Reidsville.

You have nothing to lose and whole lot to gain, Hector said. Give it a shot.

Contact JustynMelrose at (336) 349 -4331, ext. 6140 and follow@jljmelrose on Twitter.

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Brexit triggered, preprint push and a stem-cell first : Nature News … – Nature.com

Posted: April 1, 2017 at 8:48 am

Policy | Facilities | Publishing | Events | People | Research | Funding | Announcement | Trend watch | Coming up

Brexit triggered The UK government made good on its promise to trigger Article 50 on 29March and formally began the process of leaving the European Union. In the run up, Stephen Metcalfe, chair of the House of Commons science select committee, released a report on 22March, produced with scientific and industry groups and research charities, setting out science priorities for the upcoming negotiations over the future relationship between Britain and the EU. These include providing certainty for non-UK EU scientists working in the United Kingdom and maintaining funding levels for research.

Military research The Science Council of Japan (SCJ) on 24 March called on Japans government to keep military research out of universities and institutions. The statement by the SCJ, an independent body that represents 830,000 Japanese scientists and acts as an advisory body to the cabinet, was prompted by recent efforts to involve Japans universities and research institutes in military research. The declaration refers directly to the Acquisition, Technology and Logistics Agency, set up in the defence ministry in 2015 to fund dual-use research. The statement reflects on Japans history of mobilizing science in military efforts a reference to the Second World War and says that scientists must maintain their freedom and autonomy.

GM impasse Crop companies seeking to grow genetically modified varieties of maize (corn) in the European Union were disappointed on 27 March. In a vote, the European Commission failed once more to gain the required majority from the EUs 28 member states to authorize cultivation of two new varieties of maize from Pioneer and Syngenta, and to renew authorization for Monsantos MON810 variety, the only GM crop so far approved in the EU. The European Food Safety Authority has deemed all three varieties safe. The outcome means that the Commission will now make the final decisions on the authorizations itself. But, exploiting 2015 rules that allow member states to opt out of cultivating individual GM crops, 19 have already stated they will ban cultivation of these varieties in all or part of their territories, whatever the Commission decides.

Environmental fears halt India detector The India-based Neutrino Observatory (INO), a facility to be built underground in the southern state of Tamil Nadu, must seek new environmental clearances. The long-delayed INO was finally given budgetary approval in 2015, and is to study masses and other properties of neutrinos. On 20March, the National Green Tribunal in Chennai deemed that the 15-billion rupee (US$220-million) project needs a higher standard of environmental clearance because of the sites proximity to a national park. The projects leaders must now make a new proposal and seek permission from the National Board for Wildlife. Environmentalists are concerned about potential effects on the biodiverse Western Ghats. In 2009, a proposed site was rejected because it was deemed too close to a tiger reserve and an elephant corridor.

Frans Lanting/National Geographic Creative

An aerial view of the Nilgiri Hills in Indias Western Ghats.

Open-access push Four California universities have formally committed themselves to the goal of making all scholarly publishing open access. On 20 March, the University of California (UC) Berkeley, UCDavis, UC San Francisco and California State University, Northridge, signed up to an international initiative called OA2020, launched by Germanys Max Planck Society in 2015. Its aim is to push publishers towards open-access business models. The universities are the first academic institutions in the United States to sign up to the initiatives expression of interest, now endorsed by 82 universities and scholarly organizations worldwide.

Preprint policy For the first time, researchers applying for grants from the US National Institutes of Health (NIH) will be allowed to cite their studies published on preprint servers, including draft manuscripts, in applications. The NIH said on 24 March that the change is intended to speed up the review process and enhance the rigour of researchers work. Open-access advocates have applauded the policy. But critics worry that grant reviewers will not be able to distinguish between peer-reviewed research and early data, and that the policy will promote hype of incomplete results.

Post-Brexit plans A survey of 201 Spanish scientists working in Britain finds that 30% of them have changed their plans because of Brexit. Another 43% are putting off decisions until the outcome of the negotiations that will determine Britains future relationship with the European Union, according to the survey. The poll, of members of the Society of Spanish Researchers in the United Kingdom, was carried out in late 2016. Access to European funds and immigration policy are among the main concerns of the researchers, half of whom do not qualify for permanent residency. An estimated 5,000Spaniards work at public and private UK research institutions.

Pipeline approved The government of US President Donald Trump issued a permit for the construction of the contentious KeystoneXL pipeline on 24March, reversing the decision of the previous administration to block the project. The pipeline would transport crude oil from tar sands in Canada to the Gulf of Mexico and is controversial in part because tar-sands oil is more polluting than conventional crude.

CRISPR patent The European Patent Office announced on 23March that it intends to grant the University of California a key patent on the gene-editing technique CRISPRCas9. The patent would cover the use of the technology in both prokaryotic cells, such as bacteria, and eukaryotic cells, including those of plants and animals potentially the most lucrative application of the technique. By contrast, in February the US Patent and Trademark Office decided that the universitys US patent application did not adequately specify applications of CRISPRCas9 in eukaryotes, and thus did not overlap with another patent from the Broad Institute in Cambridge, Massachusetts, that covers eukaryotic uses of the technology. The scope of the University of Californias European patent could still be narrowed in response to challenges by outside parties.

Moon mission China and Saudi Arabia have signed a memorandum of understanding to collaborate on Chinas Change 4 Moon mission. Change 4 will be the first landing on the far side of the Moon and could offer a peek at a suspected volcanic structure, the history of which has intrigued scientists. Chinas Change 3 mission landed a rover on the Moon in 2013, but the machine lost mobility, disappointing scientists who had hoped for a wide survey of the lunar surface. Saudi Arabia also has an active satellite-launching programme and is partnering with Russia on plans to build an international space station.

Jemal Countess/Getty Images for TIME

AI researchers Andrew Ng, a leading machine-learning researcher, announced on 22 March that he plans to leave the Chinese technology giant Baidu. Ng has been chief scientist at the firms Silicon Valley research lab since 2014, while retaining a role at Stanford University in California. Ng says that he plans to continue to work in artificial intelligence (AI), and hopes to shepherd in the important societal change it offers. The departure is one of two key staff losses at Baidu: on 23 March, Tencent, the Chinese firm behind the social-media application WeChat, announced that it had hired the head of Baidus Big Data Lab, Zhang Tong, to lead its growing AI research efforts.

iPS cell trial A Japanese man in his 60s has become the first person to receive cell transplants derived from another persons induced pluripotent stem (iPS) cells. A team led by Masayo Takahashi at the RIKEN Center for Developmental Biology in Kobe reprogrammed anonymous donor skin cells into retinal cells, and on 28March transplanted them into the retina of the man, who has the eye disease age-related macular degeneration. In a similar 2014 trial by the team the first to use iPS cells in humans a Japanese woman received iPS-derived retinal tissue created from her own skin cells. The latest surgery is expected to pave the way for more applications of iPS cell technology, which offers the versatility of embryonic stem cells with fewer ethical difficulties.

Canadas freeze Canadas budget on 22 March presented scientists with an unexpected freeze on their main basic-research funding streams. Prime Minister Justin Trudeaus government made good on its promises to emphasize innovation and to encourage links between industry and academia, promising to establish Innovation Canada, a platform to coordinate support for Canadian entrepreneurs. But Canadas three major research councils, for the natural, health and social sciences, were given no budget increases. The plan did set aside Can$2million (US$2.5million) to fund the post of chief government science adviser, a key campaign promise of Trudeaus Liberal party.

Gates open access The Bill & Melinda Gates Foundation in Seattle, Washington, will launch its own open-access publishing venture this year, it announced on 23March. The initiative, Gates Open Research, will be modelled on a service begun last year by the Wellcome Trust in London. The Gates Foundations platform is intended to accelerate the publication of articles and data from research funded by the charity. The foundation implemented a publishing policy in January that mandates that the research it funds must be open access as soon as it is published.

Standing up for science Nominations are invited for the John Maddox Prize, which rewards an individual in any country who has promoted sound science and evidence on a matter of public interest. The 2,000 prize puts emphasis on those who have faced difficulty or hostility for their efforts. It is awarded by Nature, the London-based charity Sense about Science and the Kohn Foundation. The deadline for nominations is 31 July.

Around 85% of Natures readers are plagued weekly by invitations from apparently bogus and potentially predatory journals, an online poll answered by more than 5,300 people suggests. Most (52%) reported receiving 15 nuisance invites in the week of the survey; 17% received 10 or more. The invites, usually by e-mail, often ask scientists to publish papers with the journals or to become editors. Predatory journals are those that charge fees to publish papers without providing expected publishing services.

116 AprilThe information age is the focus of the Edinburgh International Science Festival.

26 AprilThe American Chemical Society holds its spring national meeting in San Francisco, California.

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Some restoration drama at the Big A as Dodgers top Angels, 3-1 – Los Angeles Times

Posted: April 1, 2017 at 8:47 am

Dodgers left-hander Rich Hill put some distance between himself and his spring of discontent Friday night, while Angels right-hander Garrett Richards put the finishing touches on his spring time of renewal.

Hill allowed four hits in 3 2/3 scoreless innings in a 3-1 exhibition victory at Angel Stadium, striking out two and walking one, a marked contrast from the 8.03 earned-run average he posted in five Cactus League starts, when he walked 14 and struck out 13 in 12 1/3 innings.

Hill said he was not particularly worried about his spring numbers. After all, he posted an 11.25 ERA last spring, then a 2.12 ERA during the season. Still, he was pleased with his performance Friday.

Everything is going in the right direction, he said. Today was a good outing, a good way to finish up spring training.

He said his curve and slider were the sharpest they had been all spring.

It was pretty weak contact throughout the game, he said. I think thats an indication of how the ball is coming out of your hand.

Richards allowed one run and two hits in four innings, striking out three and walking one in a 57-pitch tuneup for his regular-season debut Wednesday in Oakland.

His only blemish was a 1-and-1 slider that Justin Turner lined over the left-field wall in the fourth for a solo home run, giving the Dodgers third baseman, who is batting .385, a team-leading four homers and 16 runs batted in for the spring.

That Richards will open the season in the rotation is something of a miracle considering his setback last spring. He tore the ulnar collateral ligament in his right elbow in May and seemed headed for Tommy John ligament-replacement surgery.

Instead, he opted for stem-cell therapy, in which stem cells from his own bone marrow were injected into his elbow. A procedure that didnt work for teammate Andrew Heaney worked for Richards, who pitched in the instructional league last fall and has looked strong this spring, his fastball clocked in the 96-mph range.

I just feel very blessed, very thankful, for my teammates, who stood by me the whole time, for our training staff and doctors, Richards said. Everybody did such a great job with me, and I really appreciate it. Its been a long time, and Ive got to watch a lot of baseball, so its good to be out there competing again.

Richards said any doubts about the integrity of his elbow were eliminated in the instructional league. He had to overcome a similar mental hurdle in the spring of 2015 when he returned from major left-knee surgery.

I feel normal, Richards said. My body is finally feeling complete again. Im over the knee, my arm feels good.

Richards only concession to the elbow injury will be a pitch limit that the Angels hope to keep at around 100. A workhorse by nature, Richards threw 118 pitches and 115 pitches in consecutive April games last season.

I dont think well see 110-pitch outings from Garrett, but theres nothing to say he wont pitch deep into games, Angels Manager Mike Scioscia said. I think the extremes with Garret are something well avoid. Early in the season, were not going to see him throw 115 pitches. It just doesnt make sense.

The Dodgers were encouraged by Hills command Friday night, when he walked one of 16 batters after walking 14 of 58 batters in Arizona. He struck out Albert Pujols looking at a looping curve to end the first. He pitched out of a two-on, two-out jam in the second and retired the side in order in the third.

Left fielder Andrew Toles helped Hill with a running, lunging catch of Jefry Martes drive to the wall in the fourth, and Hill finished his night by striking out Danny Espinosa looking at a full-count curve.

The Dodgers scored twice off Angels reliever Kirby Yates in the eighth when Erick Mejia and Franklin Gutierrez led off with doubles and Cody Bellinger hit a two-out RBI double.

Angels right-hander Blake Parker may have solidified a bullpen spot when he struck out the side in the ninth, extending his consecutive strikeout string to 17 batters.

Dodgers closer Kenley Jansen struck out two of three in the fifth, and probable Angels closer Cam Bedrosian retired the side in order in the seventh, giving him nine scoreless innings this spring.

mike.digiovanna@latimes.com

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Some restoration drama at the Big A as Dodgers top Angels, 3-1 - Los Angeles Times

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Can a beating heart tissue grow on a spinach leaf? Yes, and WPI did it. – The Boston Globe

Posted: April 1, 2017 at 8:47 am

Scientists have made progress toward solving a fundamental challenge in the quest to engineer human tissue. They have a colleague who likes spinach to thank.

A team from Worcester Polytechnic Institute joining researchers from the University of Wisconsin-Madison, and Arkansas State University has grown a piece of heart tissue on a leaf of spinach that beats and sends fluids through the vascular system just like a human heart would.

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Their findings are being published this May in the scientific journal Biomaterials.

Researchers stripped the spinach of its plant cells and cultured human heart tissue in its place. The hope is that by using plants naturally occurring network of veins scientists will be able to grow organs vastly more complex than what current 3D technology allows, said Tanja Dominko, associate professor of biology and biotechnology at Worcester Polytechnic Institute.

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One of the broadest challenges for tissue engineering is how to make [the tissue] clinically viable, Dominko said. To do that, it needs to be big. But engineered tissues dont survive well at large sizes. So we looked to where these kinds of circulatory systems exist in nature.

It turns out that plants have a very similar system and thought how much engineering would be needed to grow tissue on a plant? It turns out, not much, she said.

The idea to use spinach came about because someone in the office always had it for lunch, Dominko said.

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Dominko said the hope is that tissues could be grown on plants before being grafted onto damaged organs inside the human body. While this is very exciting news, Dominko said, it could still be a long time before that becomes a reality.

Its almost impossible to say with things like this, she said. You look at things like stem cell therapy. That was discovered 20 years ago, but its still rare. It might take a long time, but Im hopeful that it wont.

The next step is to take some plant-grown tissue in mammal subjects and see how the body reacts, Dominko said.

Weve designed an experiment to see how a mammalian system reacts to the new tissue. Well watch for any kind of adverse reaction like system failure and what happens when the plant structure eventually gives out, she said.

While getting a plant-grown heart, lung, or muscle may be years away, there is no doubt that seeing what was a once-green spinach leaf beat with life is exciting.

As the researchers wrote in their study, The development of decellularized plants ... opens up the potential for a new branch of science.

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Beating Human Heart Tissue Grown on Spinach – Anti Aging News

Posted: April 1, 2017 at 8:47 am

Posted on March 29, 2017, 6 a.m. in Cardio-Vascular Bioengineering

Researchers have cultured beating human heart cells on spinach leaves that were stripped of plant cells.

Research teams from Worcester Polytechnic Institute (WPI), the University of Wisconsin-Madison, and Arkansas State University-Jonesboro are trying to take human tissue generation to a new level to treat disease and serious injuries. The hope is to soon generate working tissue, organs, and bones to implant into patients. The main problem is how to efficiently deliver oxygen and nutrients deep into developing tissue. Current technology like 3D printing has not yet matured to do this, so researchers are trying to solve this problem by decellularizing plants and using the plants scaffolding to grow human tissue on. This new technology could unlock a new branch of bioengineering. In addition to the University researchers, specialists in plant biology and human stem cell research joined in on the project. This interdisciplinary research is expected to deliver novel solutions. Cardiac Tissue Grown on Spinach Leaves

Decellularized plants could be the answer to solving a host of limitations that tissue engineering has had to face in the past, and there are abundant plant species to choose from. The team of researchers conducted a series of experiments on decellularized spinach leaves stripped of all the cells leaving just the scaffolding. They were able to get fluids flowing through the plant's network of vessels and seeded the scaffold with functioning human heart cells. The hope is to use this technique to build layers of new heart tissue for heart patients.

Using spinach leaves, the researchers designed a technique called perfusing using a solution of detergents which is pressed through the veins of the leaves. The acidic solution dissolves the cells of the leaf leaving behind the scaffolding made of cellulose which is biocompatible with humans. This method has been used successfully before in regenerative applications to grow bone and cartilage tissue.

Plants Could Generate Arteries and Bone Tissues

The team of researchers are also experimenting on other plant species and expect successful results. The spinach leaf is unique for heart-cell generation applications because of the intricate network of vessels that mimic cardiac tissue. But other plants with hollow cylindrical tubes could be used to graft arteries or even generate bone tissue.

Tissue generation using plants may prove to be very cost-effective and environmentally friendly. Compared to the limitations and higher cost of composite or synthetic materials, plants are a sustainable source of scaffolding for tissue engineering. Research is continuing with the goal of optimizing the process of plant decellularization. Further research is needed to determine how different human tissues cells will grow and how they will be nourished on the scaffold of various plants. Finally, work is continuing on improving the vascular network necessary for the flow of blood in the human tissue.

Joshua R. Gershlak, Sarah Hernandez, Gianluca Fontana, Luke R. Perreault, Katrina J. Hansen, Sara A. Larson, Bernard Y.K. Binder, David M. Dolivo, Tianhong Yang, Tanja Dominko, Marsha W. Rolle, Pamela J. Weathers, Fabricio Medina-Bolivar, Carole L. Cramer, William L. Murphy, Glenn R. Gaudette. Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds. Biomaterials, 2017; 125: 13 DOI: 10.1016/j.biomaterials.2017.02.011

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BioShares Biotechnology Clinical Trials Fund(NASDAQ:BBC … – ETF Daily News (blog)

Posted: April 1, 2017 at 8:45 am

March 31, 2017 9:38am NASDAQ:BBC

From Zacks: After being stressed by the twin attacks of higher drug pricing and increased regulatory scrutiny, the biotech sector has made a strong comeback in the first quarter of 2017.

In fact, BioShares Biotechnology Clinical Trials ETF (BBC Free Report) tops the list of the best performing ETFs of the quarter, with impressive returns of about 27.4%. BBC carries a Zacks ETF Rank of 3 or Hold rating with a High risk outlook.

The surge in the fund was largely driven by cheap valuation, robust earnings results and a slew of positive actions taken by the President. In particular, Trump promised to reduce federal regulations by 7580% and streamline the Food & Drug Administration (FDA) approval process. This would make it easier for biotech companies to bring new products to the market. Trumps proposed tax reforms and cash repatriation policy are also supporting the rally (read: Top ETF Stories of Q1 from Wall Street).

Apart from these, encouraging industry trends including the possibility of increased M&A activity, an accelerated pace of innovation, promising drug launches, growing importance of biosimilars, cost-cutting efforts, an aging population, expanding insurance coverage, the growing middle class, an insatiable demand for new drugs, and ever-increasing health care spending are fueling growth in the sector.

Lets take a closer look at the fundamentals of BBC and its performance.

BBC in Focus

This fund has a novel approach to biotechnology investing with exposure to companies that are in the clinical trials stage. This can easily be done by tracking the LifeSci Biotechnology Clinical Trials Index. BBC is a small cap centric fund, having amassed $24.4 million in its asset base. It charges 85 bps in fees per year from investors and trades in light average daily volume of around 14,000 shares.

Holding 70 stocks in its basket, it is widely spread out across various components with none holding more than 3.34% share. Though almost all the stocks in the funds portfolio delivered strong returns, a few were the real stars that more than doubled their size (read: Hit ETFs & Stocks from the Top Sector of February).

Below we have highlighted those five best-performing stocks in the ETF with their respective positions in the funds basket:

Best Performing Stocks of BBC

Esperion Therapeutics Inc. (ESPR Free Report) : The stock has surged about 185% so far this year and carries a Zacks Rank #3 with solid Industry rank in the top 39%. Most of the gains came on hopes of the Food and Drug Administrations (FDA) approval to the cholesterol-lowering medicine bempadoic acid. However, Esperion saw its earnings estimates deteriorating from a loss of $3.46 to a loss of $6.27 for this year over the past 90 days. It also has an unfavorable VGM Style Score of F. ESPR occupies the top spot in the funds basket with 3.3% of the total assets (see: all the Health care ETFs here).

Global Blood Therapeutics Inc. (GBT Free Report) : This stock takes the second position in the funds basket with 2.8% allocation. It has also delivered incredible returns of 169% in the first quarter on rumors of the takeover of a big pharma name like Novo Nordisk (NVO). The stock saw its earnings estimates moving from a loss of $2.89 to a loss of $2.83 for this year over last the 90 days. Further, it belong to a solid Industry with a Zacks Rank in the top 43%. The stock has a Zacks Rank #3 with a VGM Style Score of F.

TG Therapeutics Inc. (TGTX Free Report) : It currently has a Zacks Rank #3 with a VGM Style Score of F. The stock soared nearly 150% in the first quarter with most upside coming after positive study results from its phase 3 clinical trial of treatment for high-risk leukemia patients. However, TG Therapeutics saw negative earnings estimate revision of a nickel for the current year over the past 30 days and has an ugly Zacks Industry rank in the bottom 32%. The stock is the third firm and accounts for 2.7% share in BBC (read: Trump Tweet on Drug Pricing Hits Biotech and Pharma ETFs).

Cara Therapeutics Inc. (CARA Free Report) : The stock has been climbing since the start of the year and has gained about 105.5% this quarter on the pending trial results of its lead drug candidate. It hit a new one-year high of $20.90 in the last trading session after the company announced positive results from part A of a phase 2/3 trial for chronic kidney disease-associated pruritus. Cara Therapeutics has a solid Zacks Industry rank in the top 43%. However, it has a Zacks Rank #4 (Sell) with a VGM Style Score of F. The stock occupies the fourth position in the funds portfolio, making up for 2.5% share.

NewLink Genetics Corporation (NLNK Free Report) : This stock takes the seventh spot in the funds basket with 2.2% of assets. It has doubled this quarter but saw negative earnings estimate revision of $1.21 for this year over the past 90 days. NewLink Genetics currently has a Zacks Rank #3 with a VGM Style Score of F and solid Zacks Industry rank in the top 43%.

The BioShares Biotechnology Clinical Trials Fund (NASDAQ:BBC) was unchanged in premarket trading Friday. Year-to-date, BBC has gained 25.75%, versus a 5.59% rise in the benchmark S&P 500 index during the same period.

BBC currently has an ETF Daily News SMART Grade of A (Strong Buy), and is ranked #23 of 36 ETFs in the Health & Biotech ETFs category.

This article is brought to you courtesy of Zacks Research.

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