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Stem cells shown to restore erection capability in men with erectile dysfunction – Science Daily

Posted: March 28, 2017 at 4:41 am


Medscape
Stem cells shown to restore erection capability in men with erectile dysfunction
Science Daily
In recent years several groups have worked to develop stem cell therapy as a cure for erectile dysfunction, but until now the improvements have not been sufficient to allow affected men to achieve full sexual intercourse. Results presented at the ...
Just ONE injection of stem cells from a man's stomach could be a permanent cure for impotence (and even help them to ...Daily Mail
Scientists find cure for erectile dysfunction would you do THIS for better erections?Daily Star
Erections Restored With Fat Cells After ProstatectomyMedscape
Medical Daily
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Five ways to ward off Type 2 Diabetes – Gadsden Times

Posted: March 28, 2017 at 4:40 am

Special to The Times

Diabetes affects nearly 30 million people in the United States a stunning 10 percent of the overall population. And recent research reveals that diabetes is now the third leading cause of death, not the seventh, as was previously thought. Perhaps the most concerning statistic is that one in four persons living with diabetes is unaware that they have the disease.

The American Diabetes Association sponsors Diabetes Alert Day to serve as an annual wake-up call. The organization wants to remind Americans about the seriousness and prevalence of diabetes, particularly when the disease is left undiagnosed or untreated. This year, Diabetes Alert Day is Tuesday.

Researchers estimate that, if current trends continue, one in three Americans will have diabetes by the year 2050. Left untreated, diabetes can lead to kidney failure, limb amputations, blindness and even death. Early diagnosis and treatment is critical to preventing irreversible damage to your health and longevity, so awareness and access to care are the key areas of focus.

Here are the top five ways to keep blood sugar at healthy levels, and to keep Type 2 diabetes from impacting you and your loved ones:

1. Get more physical activity. You dont have to run marathons for physical activity to add years to your life. Just 30 minutes of intentional activity, at least five times per week, can make a huge difference for insulin resistance. A mix of aerobic, heart-pumping activity with some resistance training is the best plan.

2. Get plenty of fiber. Fiber has many benefits, including improving blood sugar management. Sources of fiber include fruits, vegetables, beans, whole grains and nuts.

3. Choose whole grains. Make sure at least half of your grain intake is whole grains. Whole grains are prepared as close to the source from the Earth as possible. Look for labels that say whole grains, and opt for organic when possible.

4. Lose a little weight. Losing even 5 or 10 pounds appears to have an impact on reducing blood sugar levels and insulin resistance. Dont focus on huge goals celebrate the small wins!

5. Skip the fad diets. Yo-yo dieting and fad diets are hard on the heart, the mind, and your organs. Just make good, whole food choices 80% of the time, and your body will work the way it was designed.

If you have a family history of diabetes, you are at increased risk for developing Type 2 diabetes yourself. Also, the condition is more common in African-Americans, Hispanics, Native Americans, Asians and Pacific Islanders. Above-average body weight increases diabetes risk for people of all backgrounds.

Only your doctor can tell for sure if you are diabetic or pre-diabetic. As part of your annual health physical, be sure to talk to your doctor about the results of your fasting blood sugar and A1C tests. If your numbers are heading in the wrong direction, you can act quickly to get back on the right track.

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Type 2 diabetes reversed with new drug in mouse study – The San Diego Union-Tribune

Posted: March 28, 2017 at 4:40 am

Type 2 diabetes has been reversed in mice with a new, orally available drug, according to a study led by San Diego scientists. The study suggests a path for developing human therapies based on the drug.

The drug protected mice from high-fat induced diabetes without affecting body weight, according to the study. It also reversed signs of the disease in mice who already had it.

Type 2 diabetes is caused by insulin resistance. While the pancreatic islets still make insulin, the hormone doesnt work as well. Cells sense insulin through receptors, which become less effective in this type of diabetes.

Scientists led by Nunzio Bottini of the La Jolla Institute for Allergy & Immunology countered insulin resistance by designing a drug that restored the effectiveness of insulin receptors.

The drug inhibits an enzyme called a low-molecular-weight protein tyrosine phosphatase, or LMPTP. Its part of a family of enzymes that inactivates the insulin receptor. By inhibiting this particular enzyme in the liver, insulin receptor effectiveness was restored.

Our findings suggest that LMPTP activity plays a key role in the development of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes, the study stated.

While the role of protein tyrosine phosphatases in Type 2 diabetes has been known for years, many enzymes in this family perform other functions,and drugs against these enzymes may also affect other targets. The drug arising from the research is exceptionally selective in its activity, the researchers said, reducing the chance of side effects.

The study was published Monday in Nature Chemical Biology. It can be found at j.mp/diabetestyr. Bottini was senior author. Stephanie M. Stanford, also of the La Jolla institute, was first author. Other local authors are from UC San Diego and Sanford Burnham Prebys Medical Discovery Institute.

We envision that the information we collected about its mechanism of action and binding mode will pave the way for development of LMPTP inhibitors suitable for therapeutic testing in human diabetes, the study stated.

Since LMPTP has also been proposed to promote heart failure and tumor growth, such inhibitors are predicted to have a wide range of therapeutic applications.

Stroke, Alzheimers disease, cognitive decline and polycystic ovary syndrome are among the other diseases that have been linked to insulin resistance.

A researcher not involved in the study told New Scientist that the research is promising.

The elegant studies here provide proof of concept that targeting LMPTP in the liver improves glucose control and liver insulin signalling in animals, Daniel Drucker, a senior investigator at the Lunenfeld-Tanenbaum Research Institute in Toronto, Canada, said in the New Scientist article.

Researchers started their search by screening 364,168 small-molecule compounds from the National Institutes of Health Molecular Libraries Small Molecule Repository. They found three hits, or molecules active against the target. One was selected for further study because of its potency and specificity.

Using medicinal chemistry, the researchers tweaked the molecule to make it more potent. One of the resulting compounds was then tested in live mice.

The La Jolla Institute for Allergy and Immunology and Sanford Burnham Medical Discovery Institute hold a pending patent on the discovery.

The researchers were funded by grants from the National Institutes of Health and the American Diabetes Association.

bradley.fikes@sduniontribune.com

(619) 293-1020

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Diabetes Risk and the Early Stages of Schizophrenia – Psychology Today (blog)

Posted: March 28, 2017 at 4:40 am

Diabetes Risk and the Early Stages of Schizophrenia
Psychology Today (blog)
Past research has shown that people with schizophrenia have higher risk of developing type 2 diabetes. Type 2 diabetes is a progressive disease in which the body either can't use its own insulin efficiently or doesn't make enough insulin, a hormone ...

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Why Climate Change Is Hiking Diabetes Rates | Reader’s Digest – Reader’s Digest

Posted: March 28, 2017 at 4:40 am

bikeriderlondon/ShutterstockClimate change isalready behind a surprising number ofadverse environmental and health effects, including malaria and dengue fever, and new research suggests that it could also be at the center of climbing diabetes rates. But it has nothing to do with melting ice caps, rising sea levels, shrinking crop yields, and a surge in mosquito populations. Instead, it has to do with a type of fat we have in our body called brown fat.

For the study, published in the journal BMJ Open Diabetes Research and Care, researchers from Leiden University Medical Center analyzed the number of diabetes diagnoses between 1993 and 2013 using data provided by the Centers for Disease Control in the United States, and discovered that with a rise in average temperature came an increase in the instances of diabetes. Data showed that as the annual temperature rose by 1 degree Celsius (or 1.8 degrees Fahrenheit), the number of diabetes cases rose by 3.1 per 10,000 people.

One of the studys researchers, Lisanne L. Blauw, BSc, of Leiden University Medical Center, told MedPage Today: We were surprised by the magnitude of the effect size, as we calculated that a 1 degree Celsius rise in environmental temperature could account for more than 100,000 new diabetes cases per year in the U.S. alone.

Researchers couldnt explain exactly why the bump in temperature caused an increase in diabetes, but they believe that it could be due to a lack of brown adipose tissue (BAT), a natural fat the body relies on to keep warm in cooler temperatures. In warmer climates, BAT is not as necessary in the body, and its lack of activation could contribute to insulin resistance and diabetes.

Our data is consistent with the hypothesis that a decrease in BAT activity with increasing environmental temperature may deteriorate glucose metabolism and increase the incidence of diabetes, the study authors write.

Based on their findings in the United States, researchers then analyzed their data on a global scale and found similar results: As the temperature rose by 1 degree Celsius around the world, the number of diabetes cases rose by nearly 0.2% and obesity rates rose by 0.3%.

This study could be a positive step forward in further treatment and research for the more than 29 million Americans that the Center for Disease Control report have diabetes. The researchers plan to continue their studies further. Heres one diet that can help you reverse and avoid diabetes risk factors.

Since cold exposure may not be the optimal strategy to prevent and/or treat type 2 diabetes, we are currently exploring pharmacological strategies with drugs that mimic the beneficial effect of cold exposure, Blauw said.

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Diabetes: Nutrition | myfox8.com – myfox8.com

Posted: March 28, 2017 at 4:40 am

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Normally, our bodies break down the food we eat into sugars, or glucose, which is a necessary nutrient for our cells. When you have diabetes, the glucose doesnt move into your cells as quickly, causing a backup of sugar in the blood, commonly known as high blood sugar. To manage your blood sugar levels, its important to understand which foods will raise your levels and to spread them out throughout the day to avoid a spike.

Taking steps to treat or manage diabetes doesnt mean living in deprivation; it just means eating a balanced diet. The biggest difference in a diabetics eating plan and a healthy diet for non-diabetics is that you need to pay more attention to some of your food choicesmost notably the carbohydrates you eat such as starches, fruits and milk products. The body needs carbohydrates as an energy source, but they turn completely into glucose and can spike your blood sugar if they arent spread out. Vegetables, meat and fat have less of an impact on your blood sugar levels and should be part of your daily intake.

Food labels are an extremely important tool when managing diabetes. The very first thing you should look at is the serving size, as serving sizes vary greatly among different foods. The serving size serves as your reference point when reviewing the rest of the nutritional information on the label. For carbohydrates, it helps to consider a serving size as about fifteen grams, and decide from there how well the food will fit in your nutritional plan. The team of registered dieticians and diabetes educators at the Cone Health Nutrition and Diabetes Management Center is dedicated to educating diabetic patients throughout the community how to manage their disease through proper diet and exercise.

Spokesperson Background:

Beverly Paddock is a registered dietitian and certified diabetes educator at Cone Health Nutrition and Diabetes Management Center. Paddock received a Bachelor of Science from the University of Georgia in 1979. She became a registered dietician through a work-study program in Florida in 1982 and became a certified diabetes educator in 1983.

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Scientists discover new class of anti-diabetes compounds that reduce liver glucose production – Science Daily

Posted: March 28, 2017 at 4:40 am

Scientists discover new class of anti-diabetes compounds that reduce liver glucose production
Science Daily
Suppressing this overproduction makes PGC-1 a target ripe for exploitation in anti-diabetes treatments. "After the screening process found several potential candidates, the TSRI team designed derivatives of those initial hits," Griffin said. "We ...

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The mystique of the invisible: Understanding mental illness – Glens Falls Post-Star

Posted: March 27, 2017 at 3:44 am

GLENS FALLS It was on the back porch of Annies Baltimore group home that she, while pausing from pulling in the inhaled vapors of a Pall Mall, recited without announcement or ceremony the Gettysburg Address.

And it was in this moment that Michael Mack made sense of it all. Made sense of his mothers life. Made sense of her years of living with schizophrenia, her electroshock therapy, her lengthy hospitalizations, her arrests, her time living on the streets.

I was stunned by it, he said in a phone interview Thursday from his Cambridge, Massachusetts home. It was a testimony to her life. When I think of all of the others who had mental illness, these people have not died in vain.

Mack, an award-winning poet, playwright and actor, now weaves the Gettysburg Address into his poems, his full-length play about how his family waded through life with his mothers mental illness and her eventual recovery.

In his poem, Heart, Mack writes, At the words from these honored dead we take increased devotion I imagined the tens of thousands of mental patients before her who died locked up, forgotten, nameless, these words her call to the unfinished work of finding in their memory a purpose that these dead shall not have died in vain. She closed her textbook circuit road trip of the Gettysburg Address with a drag on her cigarette.

On April 8, Mack will join other writers, poets, artists and musicians for an evening of sharing at the Charles R. Wood Theater for the Come As You Are performance. Through staged readings and songs by area and national writers and musicians, affected in some way by mental illness, the audience gets a first-hand glimpse of how mental illness winds into and around our lives.

And organizers hope the performance begins to dispel the myths and stigma associated with mental illness.

Featured cast members include Mack and Marya Hornbacher, an award-winning journalist, bestselling author, and Pulitzer-nominee for her book Wasted: A Memoir of Anorexia and Bulimia.

Organizer and director Logan Beth Fisher, who has experienced mental illness in her family and she herself has struggled with clinical depression, said this years theme is Embrace.

Doing these shows is a way to do something, to feel a little less helpless. This is my way to contribute of doing something to make the taboo less, she said. When you share stories, there is an inspiration (for people to know,) I am not alone.

We hope people will understand and realize that people with mental illness are your neighbors, co-workers. They are really successful human beings, she said in an interview on Wednesday. It doesnt have to be taboo. One in five people this year will experience some kind of mental illness.

The proceeds from the show will support the services of the Warren-Washington Association for Mental Health. They do such incredible work, Fisher said.

WWAMH serves thousands of individuals in the area. There are 12,000 visits to our outpatient clinic in Hudson Falls, said Nicole Casey, human resources director and community relations manager of WWAMH. Part of our mission is to talk about mental illness in the community. We are hoping the public embraces this event and it puts mental illness on the map.

The brain, with its 100 billion neurons, 900 billion glial cells, 100 trillion branches and 1,000 trillion receptors, reacts to stimuli in a series of electrical bursts, spanning a complex map of connections.

And these synaptic connections fire in ways that are not always easy to explain and in ways that scientists are starting to understand as they study what makes us do what we do.

We study the synaptic connections in brains and our goal is to understand electrical activity during behavior. But understanding the brain is not the same as understanding the heart, we know that is a pump, said Linda Overstreet-Wadiche, an associate professor at the University of Alabama School of Medicine, Department of Neurobiology, who studies learning, memory and synaptic plasticity. We havent been that successful because we dont understand how the electrical activity and synapses between neurons work.

In a study published in February, Overstreet-Wadiche and fellow scientists reported that stem cells in the hippocampus the part of the brain where memories are made make newborn neurons.

These newborn neurons can make new memories, and change older memories which can be altered or disappear.

While this science is still very new and evolving, Overstreet-Wadiche said it has been known for some time that our brain maps can be altered. And contrary to those who believe that we cannot change our brains, we can.

To simplify: We have a comfortable rut worn in our brain that we travel each day. And even if the behaviors tied to this rut are not healthy, we keep doing them because it is familiar.

The good news is, because our brains are malleable, we can alter these ruts or paths to create new ones.

And the same is true for people with mental illness; new roads can be formed.

Nonetheless, forging a new way of doing things is often painful and uncomfortable, but recovery can happen.

Connections are changing and new connections are being made, said Overstreet-Wadiche.

Come As You Are director Fisher said that her awareness came about through 20 years of therapy. And in a Wednesday afternoon interview just after her Big Cross Street School fourth-graders left for the day, Fisher discusses her own journey.

For me, its the unraveling of what was dysfunctional and learning new strategies to survive. The road is painful to let go for me it was managing the black, she said. I am a living example of that constant hard work.

Mack was a little boy when his mother was first diagnosed with schizophrenia.

Her presence was so big in our family, each of us struggled with the effects of growing up with that chaos, he said. And Mama herself endured more than any of us. She spent a lot of time in state hospitals, in jail. She was on the streets, at halfway houses.

And while Mack admits it was very sad to see her in these situations, he said things started to change for her, and the 1990s is when the family marks her recovery.

The way he explained it, two group homes she stayed in helped.

But one in particular, that focused on the aspect of community and doing things together, really helped his mother thrive. Everyone helped out with chores, they had a say in how things were done and my Mom flourished, he said. They cared for her and about her my message is about recovery, about the reality of recovery.

A few years ago, Fisher performed as a cast member in Listen to Your Mother on Broadway, and in 2015 she was invited to co-direct This is My Brave in Boston.

Representatives from the area WWAMH saw her Boston show and asked her if she would bring it to this community, and last year the show at the Wood Theater sold out, she said.

For the 2017 performance, after inviting several nationally known cast members, Fisher held auditions for the local cast at Crandall Public Library. We had 21 audition and we chose five, she said, adding that for those who did not make it, they will use excerpts and quotes from the essays not chosen as part of the evening event.

Fisher said the show has some very funny and memorable moments. Anna Rose Johnson her essay is in list form, and it is so funny, she said. Last night at rehearsal, it is brilliant, its not to be missed.

I wanted to add outside elements to keep the audience entertained, she said.

Mack said he does not charge for his performance for this event because of the important work being done.

Overcoming the stigma is part of the great work they are doing, he said about the April show.

Casey, of WWAMH, said people often look at mental illness negatively. The more the conversation opens up and these community members are so brave, facing people they know (for the performance), she said. Logan (Beth Fisher) is the creative mind behind it. Were so grateful.

In trying to explain the stigma, Casey said it is not like a broken arm. A mental illness is often invisible. And because it is invisible, it is hard for people to understand that it is real.

People are often afraid to talk about it, she said. Our work is to help people be part of the community.

Fisher hopes the April show will open minds and hearts.

Find out someones story before you make a judgment with a diagnostic twist, Fisher said. This kind of show shows you this is what mental illness looks like.

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Henrietta Lacks’ legacy collision of medicine, ethics and race – nwitimes.com

Posted: March 27, 2017 at 3:41 am

GARY Immortality comes with a catch. Something may be taken without your say. Even your loved ones wont learn about it until decades later.

So it was for the family of Henrietta Lacks, a poor black tobacco farmer. But theyre making up now.

In 1951, doctors removed cells from Lacks cancer-stricken body without her knowledge or permission. Generations later, those cells continue to be valuable tools in biomedical research.

Bad things happen to good people, so great things can be done, said Veronica Robinson, Lacks great-granddaughter. You can be part of science and see its not all that bad.

Robinson and Shirley Lacks, Henrietta Lacks daughter-in-law, addressed this collision of medicine, ethics, and race Wednesday at Indiana University Northwest. The Lacks family legacy, Robinson said, is not about what happened, but how we overcame it.

With recognition for Henrietta Lacks now coming nationally, Shirley Lacks noted, Henrietta has helped all mankind. Theres not one person who hasnt been touched or doesnt know someone touched by the HeLa cell.

Henrietta Lacks, who died in 1951 at age 31, was the unwitting donor of cells from a cancerous tumor biopsied during treatment for cervical cancer at Baltimores Johns Hopkins Hospital. Of the two samples removed from Lacks cervix, one was healthy tissue, but the other sample was cancerous. Dr. George Otto Gey, a cancer researcher at Johns Hopkins, cultured the cancerous sample into what became known as the HeLa immortal cell line.

HeLa has since been used in the polio vaccine, gene mapping, and in vitro fertilization research benefiting countless numbers of patients.

Although family members did not learn of their matriarchs contribution until 1975, today they are sharing Henrietta Lacks story, which has also been chronicled in the best-selling book The Immortal Life of Henrietta Lacks by Rebecca Skloot. An HBO movie about Lacks starring Oprah Winfrey will air April 22.

Robinson said the Lacks family today has a cordial relationship with Johns Hopkins Hospital, which has not financially compensated the family. Although she feels the family should receive something for Henrietta Lacks, she also believes the world got her best part.

When asked about race, Robinson is convinced that race was a factor in the 1951 medical procedure, while Shirley Lacks believes the issue is not about race per se, but rather about a doctor searching for a cancer cure.

The biggest impact of the Henrietta Lacks story, Robinson noted, has to do with medical ethics and humanity. These people (patients) are somebody who matters, she said. You need to treat them like you want to be treated. You need to tell them exactly what youre doing to them. Give them the right to understand.

The March 22 program concluded this years One Book One Campus One Community reading initiative at IUN. Attending were nursing students, including sophomore Amanda Pogue, who focused on ethics in the Skloot book.

Pogue, from Portage, said, Looking back 50 years ago, people are asking, 'How could they ethically do that?' Looking ahead, what will future generations say about what we do?

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Animal Clinic of Council Bluffs and Glenwood Veterinary Clinic Offer Stem Cell Therapy for Pets – P&T Community

Posted: March 27, 2017 at 3:41 am

Animal Clinic of Council Bluffs and Glenwood Veterinary Clinic Offer Stem Cell Therapy for Pets
P&T Community
COUNCIL BLUFFS, Iowa, March 26, 2017 (GLOBE NEWSWIRE) -- MediVet stem cell therapy, offered at Animal Clinic of Council Bluffs and Glenwood Veterinary Clinic, provides pets and owners with a way to address health concerns in cats and dogs.

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