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With diabetes under control, pitcher Dylan Covey tries to stick with White Sox – Chicago Tribune

Posted: March 7, 2017 at 8:44 am

White Sox pitching prospect Dylan Covey is among the many players in spring training who have no idea where they will head when the teams pack up for the regular season.

A Rule 5 draft pick in December, Covey would have to make the big-league roster out of spring training or be put on waivers and offered back to the Athletics, per major-league rules.

But at 25, Covey already is a pro at dealing with the unpredictable.

His biggest life-altering twist came in 2010 after the Brewers drafted the right-hander 14th overall one spot behind Chris Sale out of his California high school. Covey was nearing the signing deadline when a blood test from a team physical revealed he had Type 1 diabetes.

That gave him just days to figure out how to proceed.

Covey said the Brewers offered him the slot value of $1.7 million, less than what he asked for before the diagnosis, but he and his family decided to turn it down. He instead attended the University of San Diego, closer to home and his physician, while he learned to manage his disease.

"Maybe not financially speaking, but as far as my health, which is obviously more important, I think it was the right decision," Covey said. "I had all of the resources there. I'm sure the Brewers would have been great with it too, but just being so unfamiliar with it all, it was really a comfort thing. I didn't know what to expect."

When the Sox asked about Covey this offseason, he told them the diabetes "is not even an issue anymore." He knows how to eat and has an insulin pump to manage it, and he said his body is "like a normal person's now."

It took a while to get there.

The first year and a half after his diagnosis were "really tough," he said. Covey learned about counting carbohydrates and taking insulin. He lost weight before the diagnosis, and after putting it back on, he worked to turn it into muscle.

Meanwhile, he pitched 34 1/3 innings as a freshman at San Diego, though in retrospect he said he should have redshirted.

"Learning to do that at first is tough because you don't really think about how many carbohydrates you're eating every time you take a bite of food," said Covey, who is 6-foot-2 and weighs 195 pounds. "It was definitely an adjustment period I had to go through."

After three seasons at San Diego, the A's drafted Covey in the fourth round in 2013, and he signed for $370,000. He worked his way to Double A in 2016 and had a 1.84 ERA in six starts before an oblique injury. He returned to pitch in the Arizona Fall League, going 4-0 with a 4.74 ERA, before the Sox picked him up at the winter meetings in December.

It has been a more difficult journey than Covey could have imagined as a teenager.

"Who knows what would have happened if I had signed in 2010," Covey said. "It has been a little bit longer of a path, but I'm happy for the situation I am in right now with the White Sox."

The Sox are giving Covey a shot to show what he can do this spring.

He gave up two earned runs on three hits in his first one-inning appearance against the Rockies last month, an outing pitching coach Don Cooper chalked up to "anxiousness."

But he pitched two scoreless innings on 16 pitches in his start against the Padres on Friday, and he's scheduled to start again Saturday.

"He had a nice outing the other night, got nothing but ground balls," Cooper said. "He's a two-seam guy, so he's real strong with his sinker, arm-side, down and in to righties, down and away to lefties. ... I told him, now we're on the move, and now we've got to see if he can carry it into the next one."

The Sox rotation is full, barring a trade, but the club could keep Covey as a long reliever or spot starter. They also could try to strike a trade with the A's if they like what they see this spring.

Covey said he is staying focused amid the "little bit of pressure."

"If I don't make the team, I go back to the situation I was in before," Covey said. "I've just got to go out and do my best every time, and hopefully my actions prove to them that I'm worth the pick they used to get me."

Intention to start: Pitching prospect Reynaldo Lopez has made it known he hopes to remain a starter when he reaches the majors, and manager Rick Renteria reiterated Monday the Sox are sticking with that plan for now.

Renteria said he was happy with how Lopez located in his second start Sunday, when he allowed one earned run on three hits with a walk and three strikeouts in three innings.

"First inning was a little rough, but obviously he settled down and did a nice job," Renteria said. "He was commanding all of his pitches and looked very good."

WBC update: Sox minor-leaguer Alex Katz pitched a scoreless inning in Team Israel's 2-1, 10-inning victory over South Korea to open the World Baseball Classic. Katz hit one batter and had one strikeout in the seventh.

ckane@chicagotribune.com

Twitter @ChiTribKane

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Diabetes in pregnancy tied to altered fat cells in adult offspring – Fox News

Posted: March 7, 2017 at 8:44 am

When pregnant mothers have diabetes, their children may have altered fat cells that make metabolic diseases in adulthood more likely, a small Danish study suggests.

Babies of mothers with diabetes may be exposed to high blood sugar levels in the womb, a condition known as fetal hyperglycemia.

"Fetal hyperglycemia affects fat stem cells and these defects can be detected several years later," said lead study author Ninna Schioler Hansen of the University of Copenhagen in Denmark.

In lab tests, adult offspring of women who had diabetes during pregnancy appeared to have larger fat cells and more leptin, a protein made by fat cells that influences hunger.

"If (high blood sugar) or diabetes is present during pregnancy, our study supports the importance of aiming at normal blood glucose levels to reduce the negative impact on the cells of the unborn baby," Hansen added by email

"Women who are lean and fit before pregnancy have a reduced risk of developing gestational diabetes during pregnancy," Hansen said.

Hansen's team studied 206 adults, including some whose mothers had diabetes before pregnancy, others whose mothers developed a condition known as gestational diabetes during pregnancy, and a control group with mothers who didn't have diabetes at all.

Adult offspring of women with diabetes in pregnancy showed "fundamental changes" in the size of their fat cells, their ability to store fat as well as the way their bodies produced the hormone leptin, which influences appetite regulation in the brain, Hansen said.

It's possible that differences between adults with and without mothers who had diabetes during pregnancy might be explained by other factors that happened during fetal development, the authors note in the Journal of Clinical Endocrinology and Metabolism.

Even so, the results offer clues to explain the increased diabetes risk among children born to mothers with diabetes, said Dr. Joachim Dudenhausen, an obstetrics and gynecology researcher at Weill Cornell Medicine in New York who wasn't involved in the study.

Changes induced by hyperglycemia in the mother "can be responsible for diabetes of the child in later life," Dudenhausen said by email.

The best prevention is for women to start pregnancy at a normal weight and gain a healthy amount of weight while they're growing their babies.

Women who start out at a normal healthy weight should gain 25 to 35 pounds during pregnancy, while women who are overweight to start should gain no more than 25 pounds, according to the U.S. Centers for Disease Control and Prevention.

"One of the highest risk factors for gestational diabetes is being overweight before and during pregnancy," Dudenhausen said.

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Early periods associated with risk of gestational diabetes – Science Daily

Posted: March 7, 2017 at 8:44 am


Medical News Today
Early periods associated with risk of gestational diabetes
Science Daily
"A large proportion of women who develop diabetes during pregnancy are overweight or obese, and encouraging those with an early start of puberty to control their weight before pregnancy may help to lower their risk of gestational diabetes," she said.
Early period may indicate risk of diabetes during pregnancyMedical News Today
Early Periods May Increase Women's Risk of Gestational DiabetesNDTV
Early period may up gestational diabetes riskThe Tribune
TheHealthSite
all 20 news articles »

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UNL’s new College Diabetes Network hopes to raise awareness, connect students – Daily Nebraskan

Posted: March 7, 2017 at 8:44 am

Most people can think of one person they know who suffers from diabetes, and yet not everyone knows about the disease.

The University of Nebraska-Lincolns College Diabetes Network is setting out to bring awareness to the disease and to promote a supporting environment for diabetics. College Diabetes Network is a nationally Recognized Student Organization that got its start at UNL after Haley Schepers, president and founder of UNLs chapter, decided to bring it here in December 2016. The club was approved in January 2017.

Type 1 diabetes is a disease in which the pancreas stops working, affecting the production of insulin, a hormone that breaks down sugars in the body. Diabetics must use insulin shots or pumps to regulate their blood sugar levels all day every day. Type 1 is an autoimmune disease that has no known cause or cure, although has some hopethere is a cure.

Schepers and the vice president of UNLs College Diabetes Network Ansley Alberts have similar stories about why theyre dedicated to diabetes. Both have younger siblings who were diagnosed at a young age with Type 1 diabetes. Schepers sister was diagnosed at age 12, and Alberts brother was diagnosed at age 11.

Its a complete life cycle change, so being a sister to someone with diabetes is really about being a support system, Alberts said. Its always on your mind.

Now, both students are making it their goal to raise awareness about Type 1 diabetes and to change the culture on campus. They want the club to be a place where students with diabetes can talk to each other. This is especially important for freshmen who have never lived alone with the disease.

Schepers said she hopes the group can get upperclassmen to mentor underclassmen on how to live with diabetes in college. This includes learning how to handle the drinking culture as well as eating in the dining hall and regulating their blood pressure.

Students are given this freedom and they dont know what to do with it, Schepers said, Theyre thrown into this crazy culture and theyre not regulating it, and people around them dont know how to help them.

Jacinta Benton, a member of College Diabetes Network, said the group has supported her by being a place where she can have personal interactions with others who have Type 1 diabetes. Benton was diagnosed with the disease last year when she was a freshman.

Benton said she quickly learned to take diabetes one day at a time. She said she hopes students will be educated on the science behind diabetes. Benton also said she thinks its important for UNL students to know what to do in a situation when a diabetics blood pressure is too low or too high.

Students should know how to check a students blood pressure and when to give more sugar if its at dangerous levels, she said.

Benton said that reaching out to other people with diabetes helps you learn specific accommodations you can get in college.

I would recommend to people who get diagnosed to do your research and reach out to people early, she said. If you do it early, later on in your life its simpler - not easier - but simpler.

Schepers said she hopes the group can get the word out about College Diabetes Network and attract new members. She said in the future she wants students who get diagnosed to get sent straight to College Diabetes Network so they can help with the transition.

The club accepts students who have diabetes, students who know someone who has it or students who just want to help the cause. Schepers said to go to their Facebook page CDN-Lincoln to learn more about meeting times and upcoming events like an awareness campaign and their first annual Walk to Cure Diabetes on April 2 with a fraternity on campus, Delta Tau Delta.

Schepers said there is also a GoFundMe page for the event if someone cannot attend but would like to help.

We are very close to a cure for Type 1 right now, Alberts said. I think that cure can come in my brothers lifetime.

news@dailynebraskan.com

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D-backs’ De La Rosa counting on stem-cell therapy to avoid second Tommy John – Arizona Sports (registration) (blog)

Posted: March 6, 2017 at 2:46 am

Rubby De La Rosa had already undergone Tommy John surgery. So when his right elbow became an issue again, he had a tough decision to make.

He could have the surgery again and risk that it might not be as effective the second time around. Or he could venture down another avenue.

Either way, his career was at stake.

De La Rosa was in his second season as a Diamondback when it was interrupted in September by a familiar pain in his elbow.

His rookie season with the Dodgers in 2011 was cut short for the same reason. He ended up having his first Tommy John procedure.

So when the issue arose again last season, he and Dr. James Andrews who performed De La Rosas first Tommy John surgery discussed the options. They decided stem-cell therapy would be more effective than a second surgery. De La Rosa then received one stem cell injection in late September and another in December.

He has been playing catch and said he feels 100-percent healthy, but he will not begin throwing off the mound until mid-March.

What I see from it right now, its working, said De La Rosa, who will be 28 years old March 4. No more pain, no more soreness. Just waiting for my time.

Dr. Keith Jarbo is an orthopedic surgeon with OrthoArizona who specializes in elbow surgery. Jarbo, who has performed many Tommy John surgeries to repair the ulnar collateral ligament, said the procedure is less effective the second time around.

Stem-cell therapy has become more popular in orthopedics over the past five to 10 years, Jarbo said. Some doctors even use it in addition to Tommy John surgery to accelerate the healing process. He said stem cells are used because they are pluripotent, meaning they can develop into every type of cell that makes up the body.

They have a lot of the growth factors that are necessary for healing, Jarbo said. We think they can be important adjuncts for healing.

However, there is a risk. Jarbo said there is no research that compares the efficacy of stem-cell therapy to that of Tommy John surgery. With the lack of research, Jarbo said one doctor may be using different types of stem cells than another.

He said he doesnt use stem cells and wont until there is more research that shows it is effective. Until then, he cant assure his patients that stem-cell therapy will produce a ligament that has similar characteristics to what it did before the injury.

Its high-risk in the sense that we dont know exactly what its going to do, Jarbo said. We think that it promotes healing, but we dont know exactly what growth factors are within or whats going to happen.

I dont think youre necessarily getting a new, better tissue as if youre developing a robot. Youre really just trying to get good healing and strong appropriate tissue, whether thats with surgery or not.

Jarbo estimated Andrews conducts over 100 Tommy John surgeries per year. He said doctors like Andrews may be helpful in researching stem-cell therapys effectiveness if they can use stem cells on half of their patients and compare the results with the half that received Tommy John surgery.

De La Rosa is part of a group of trendsetters. Last season, Los Angeles Angels of Anaheim pitchers Garrett Richards and Andrew Heaney both received stem cell injections to stave off Tommy John surgery. Heaney ended up needing the surgery anyway.

D-backs manager Torey Lovullo said De La Rosa seems encouraged by his health.

We just know that Rubby is in a really good place, hes been throwing the ball really well hes smiling, and hes back to himself, which is always a good sign for him, he said.

Diamondbacks pitching coach Mike Butcher said stem-cell therapy is unpredictable, but seems to helping De La Rosa.

Its obviously helped out Rubby, Butcher said. The results have been good so far; he feels great. Now its just a matter of working toward the progression of where we can get him off the mound.

Jarbo said the largest risk with using stem-cell therapy may be that players are rushed back to action through an accelerated rehab program.

However, De La Rosa has been patient throughout his now five-month recovery.

He hopes it means the end of his elbow pain.

Its frustrating because sometimes you want to pitch but you cannot pitch because theres a lot of soreness, he said. When you do it right and you get hurt and everything switches, now you cant pitch with your whole motion and you have to limit a lot of things.

You get bad pitching.

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Trump’s coal council to drill down on advanced technology – Washington Examiner

Posted: March 6, 2017 at 2:45 am

President Trump's clean coal agenda could get some much-needed clarity as federal advisers take a hard look at advanced technologies to make coal plants more competitive and climate-friendly, as Trump's plan to repeal regulations will only go so far toward restoring the industry.

Some of the experts slated to lead the discussion at this year's spring meeting of the National Coal Council, a federal advisory committee, are skeptical about how much Trump can actually do over the next four years to help the coal industry beyond removing regulations.

Eliminating regulations is only a short-term remedy for what ails the coal industry. Removing Obama-era climate regulations would stop some of the planned coal plant retirements while allowing for the construction of newer, more efficient coal plants, which are considered a variant of clean coal technology.

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Top consultants say the Trump agenda needs to be paired with a longer-term strategy that looks at more advanced technology such as carbon capture and storage, or CCS, which strips carbon pollution from coal plant emissions.

Amid Trump's promise to roll back climate change rules and withdraw from the Paris climate accord, much of the talk at the March 14-15 meeting will be on ways to make the coal industry more climate-friendly through the use of CCS. But even that isn't a sure fix, and it won't have job benefits for years to come, which is Trump's primary goal.

"I think everything that drives [Trump's] policy decisions is geared at the top level, first and foremost, to jobs," said Andy Roberts, research director for energy consultants Wood Mackenzie. "He wants to restore better economic health to the energy industry."

Roberts will deliver the keynote address, aptly named "Opportunities for Coal in the Trump Administration," at the coal council meeting, according to the official agenda.

When it comes to Trump's jobs priorities, Roberts doesn't see "clean coal" technologies that Trump continues to tout offering much in the way of putting miners back to work, at least not quickly.

Also from the Washington Examiner

"At the very least you can imagine them playing a provocative role," said Rep. Peter Roskam, R-Ill.,

03/06/17 12:01 AM

"In the short-term, that means unburdening the industry from regulations to the extent [coal] competes on a level playing field," Roberts said. But clean coal technologies, primarily carbon capture and storage, "don't really impact employment in the industry in the short term and medium term at all."

"It's not economic," Roberts added. "It's never going to be economic versus other forms of energy production." But it may still be necessary, he said, "depending on what the world decides it's going to do about topics like climate change."

That's why the primary thrust of the coal meeting will be focused on CCS and enhancing "the efficiency and emissions profile of our coal fleet," according to the agenda. However, the focus of the advisory panel in Trump's first year has not been determined, Janet Gellici, the National Coal Council's CEO, said before Rick Perry was confirmed as energy secretary Thursday. The coal council reports to the secretary.

The coal council under former President Barack Obama focused on legislative and policy recommendations for advancing CCS and even more advanced technologies that use the carbon to generate additional revenue stream for power plants.

One of the technologies that will be highlighted at this month's meeting will come from a company that has been collaborating with Exxon Mobil to commercialize a form of CCS technology for reducing emissions at natural gas power plants. The company sees fuel cells as a solution to the next big challenge for cutting carbon dioxide emissions, which is anticipated to be focused on natural gas power plants.

Also from the Washington Examiner

With Trump in the White House and a GOP Congress, financial firms are well-positioned for looser regulation.

03/06/17 12:01 AM

Currently, natural gas-fired plants are taking market share from coal, since they release 60 percent fewer emissions than coal plants. Gas plants, according to Exxon Mobil, are the reason the nation's emissions are at their lowest in 25 years.

Nevertheless, any advancements in cutting carbon pollution further will stem from advancements that will come from developing CCS at coal plants, said officials with the company FuelCell Energy, which is collaborating with Exxon on CCS. Capturing carbon from natural gas is slightly different than capturing it from coal, but advancements on either would help the other fuel.

Officials with FuelCell Energy will be discussing its projects with the Energy Department, as well as the joint venture it has with Exxon. They say Trump's focus on manufacturing is good for clean coal, but also for cleaner forms of natural gas that they anticipate being needed further down the road.

"One aspect that we're certainly encouraged with is the focus on American manufacturing," said Kurt Goddard, head of investor relations for the company. "Because fuel cells represent American innovation, they represent American manufacturing."

Fuel cells had support in previous Republican administrations. Former president George W. Bush created the hydrogen fuel cell initiative to wean the nation off its "addiction to oil." But it's not clear if Trump might do something similar.

Fuel cells are a highly efficient means of producing electricity. Rather than burning a fuel, like a standard power plant does, they produce electricity through a chemical process using an electrolyte similar to a battery. But instead of charging it as a battery, the electrolyte is refilled. FuelCell Energy's device concentrates the carbon dioxide from a coal-fired power plant as part of its electricity-generation process. The process reduces carbon emissions and other pollutants.

It's also a form of clean energy that is completely made in America, Goddard said. "Our manufacturing facility is actually in Connecticut, whereas some other forms of clean power generation aren't necessarily made in the U.S.," he said, explaining why he believes Trump is supportive of CCS. It's a technology that is evolving, he said, with interest coming from Exxon, the Canadian oil sands and Europe.

Anthony Leo, the company's vice president for technology and applications, will discuss its fuel cell clean coal project at this month's meeting, in addition to the natural gas work he is doing with Exxon Mobil. The coal and gas projects are both being done at Southern Co.'s Barry Plant in Alabama.

The projects are in the engineering phase, with construction not expected to begin for about two years. Exxon CEO Darren Woods underscored the project in a blog post last month.

"Our role as the country's largest producer of natural gas which emits up to 60 percent less CO2 than coal for power generation has helped bring CO2 emissions in the United States to the lowest level since the 1990s," said Woods, who took over after predecessor Rex Tillerson was appointed secretary of state.

"But the world also will need breakthrough clean-energy technologies such as carbon capture and storage," he said, noting that the company is "investing heavily in CCS, including research in a novel technology that uses fuel cells that could make CCS more affordable and expand its use."

An Exxon official emphasized to the Washington Examiner that the company's piece of the project has received no funding or support from the government.

Roberts observed that the future of CCS could very well resemble what is being demonstrated between the fuel cell company and Exxon. He also said the "model" for clean coal could follow what is happening between SpaceX and NASA, where a private company "is driving a lot of our national space exploration activities, right now, at the direction of NASA but with cooperation."

Roberts sees demand for clean coal technology coming from Europe, where the continent's climate change policies require the technologies, even if Trump succeeds in exiting from the Paris climate agreement.

"Maybe if the U.S. steps back for a while, the driving factors happen in Europe," Roberts said.

Coal use is projected to grow globally, and there will be an increasing need for coal power plants to be made more efficient and with fewer emissions, said Benjamin Sporton, the head of the World Coal Association. He was in Washington last month to discuss advancements on coal technology with congressional staffers.

He was also in the U.S. as part of an International Energy Agency industry advisory team meeting with coal companies to get a sense of where they are on technology development, he told the Washington Examiner in an interview.

"For me it's a continuum," he said. "It's not saying let's leap to CCS today, because CCS is not a technology that is viable for widescale deployment today. It's about saying how we start on that pathway to get to somewhere further down the track."

Expanding federal incentives for carbon capture technologies was an idea supported by both parties last year. And a lobbying push by unlikely bedfellows, major coal companies and environmentalists, is gaining steam to move a similar bill in this Congress.

"When utilities, coal companies and environmental groups come together to support your bill, you know you're onto something that could work," Democratic Sen. Heidi Heitkamp of North Dakota said last year in introducing her bill to expand the coal incentives. Senate Majority Leader Mitch McConnell of Kentucky was a co-sponsor of the legislation.

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WATCH: Helping farmers through agricultural biotechnology – Rappler – Rappler

Posted: March 6, 2017 at 2:45 am

The UP Genetic Researchers and Agricultural Innovators Society strives to uphold awareness on the ways, means, and science behind agricultural biotechnology to help students and farmers alike

Published 6:59 AM, March 06, 2017

Updated 9:19 AM, March 06, 2017

MANILA, Philippines How can agricultural biotechnology help and serve farmers and students alike?

These students from the University of the Philippines Genetic Researchers and Agricultural Innovators Society or UP GRAINS found a way.

We think its important to promote biotechnology because its one of the most advanced fields of science and we think it is also neglected in the Philippines," founding Vice-President of UP Grains Kohlin Lallaban said.

UP GRAINS, which was formed in 2014 in UP Los Baos, is an academic organization that promotes agricultural biotechnology. The group helps farmers make a living. Its programs allow students from Batangas, Laguna, and Camarines Norte provinces learn about techniques in biotechnology and how they can apply these to their research.

They bring experts and professors from different universities in Laguna and Batangas to communities, teaching farmers how to grow their crops better.

The student organization has touched lives through its programs which include academic tutorials (Chem 40: Basic Organic Chemistry Tutorials), educational discussions (AgriBioTalk Series), inter-high school information drives (Lakbay-Bioteknolohiya Workshops), farmer-oriented extension programs (Ugnayan Series), interactive advocacy campaigns (#EveryButilCounts, Free Demo Shirt Printings), and even a nationwide junior research conference (Project BT).

There was this one time that we did an extension activity in Laguna. We pushed the farmers to establish an irrigation system for their farm. Right now, theyre producing almost 40% more of cavans of rice than they were able to produce before, Lallaban shared.

One of the greatest ironies in the Philippines is that food producers like farmers and fishermen are the most vulnerable to hunger. UP GRAINS wants to change this situation in rural communities. By change, they mean continuous innovation for a better future, according to Lallaban.

"We think that the biggest lesson that our organization learned from our immersions is that there are bigger things than us, there are bigger things that we have to do, there are bigger things that we have to think about and that there is no better time to do that than now." Rappler.com

UP GRAINS is a partner organization of Rappler's civic engagement arm MovePH. For more information on how you can help or be part of UP GRAINS, check out their stories on X. Know more about our other organization partners:

Do you want your organization to be part of MovePH's X Network? Email us at move.ph@rappler.com!

At Rappler, we believe there are many freedoms: to speak, to choose, to love, or just to be. #InspireCourage is our campaign to encourage people to speak up, engage in issues, and continue fighting for the change they want to see. Be part of the conversation

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Why Puma Biotechnology Inc. Got Hammered Today – Motley Fool

Posted: March 6, 2017 at 2:45 am

What happened

Puma Biotechnology (NASDAQ:PBYI) ended the day down 13.8% after Roche (NASDAQOTH:RHHBY) reported that its rival breast cancer drug, Perjeta, had passed its phase 3 trial, dubbed "Aphinity."

Image source: Getty Images.

In Roche's trial, patients either took Perjeta and Herceptin with chemotherapy or just Herceptin with chemotherapy, and then took Perjeta and Herceptin, or just Herceptin, for an additional year. Roche didn't release the full data from the clinical trial, but it did say the triple combination reduced the risk of recurrence of invasive disease or death compared to Herceptin and chemotherapy alone.

The potential to establish a new standard of care where patients take Herceptin and Perjeta for a year could be problematic for Puma Biotechnology because its drug candidate, neratinib, was tested after just Herceptin use, the current standard of care.

Without any data, doctors will likely wonder whether neratinib helps patients that have received Herceptin and Perjeta. And the relapse rate for patients on the current standard of care is already quite low; if adding Perjeta decreases it further, doctors and their patients may decide taking another drug after that isn't worth it, especially given neratinib's side-effect profile.

Investors will have to wait for the full data from Aphinity -- perhaps at the American Society of Clinical Oncology meeting in June -- to know how much better Herceptin plus Perjeta is than Herceptin alone, and how that might affect neratinib's sales, assuming it's approved later this year.

Brian Orelliand The Motley Fool have no positions in any of the stocks mentioned. The Motley Fool has adisclosure policy.

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Thursday’s Biotech Insights: Aurinia Pharmaceuticals Inc (AUPH), Puma Biotechnology Inc (PBYI) – Smarter Analyst

Posted: March 6, 2017 at 2:45 am

Aurinia Pharmaceuticals Inc (NASDAQ:AUPH) shares skyrocketed over 65% this morning, after the drug maker announced top-line results from its AURA-LV Phase IIb study with voclosporin (VCS) in patients with lupus nephritis (LN) that showed at 48 weeks, the study met its complete remission (CR) and partial remission (PR) endpoints.

FBR analyst Vernon T. Bernardino commented, We are impressed with the results, as CRs and PRs at 48 weeks exceeded CRs and PRs at 24 weeks, with one exception. As a reminder, each study arm included standard of care mycophenolate mofetil (MMF) as background therapy and a forced steroid taper. There were no unexpected safety signals or deaths observed in VCS-treated patients. Thus, in addition to strong efficacy, VCS appears to allow safe steroid sparing. We think the results are robust and bode well for a successful Phase III trial, which could make VCS the first approved therapy for LN.

As of this writing,the 4 analysts polled by TipRanks (in the past 6months) rate Aurinia stock a Buy. With a return potential of 39%, the stocks consensus target price stands at $8.50.

Puma Biotechnology Inc (NASDAQ:PBYI) shares lost one-quarter of their value today, after competitor Roche announced positive top-line results from the highly anticipated APHINITY trial,which explores usefulness of Perjeta in adjuvant breast cancer. Recall, Puma has US/EU regulatory applications under review for neratinib in the extended adjuvant setting based on positive Phase 3 ExteNET data.

J.P Morgan Cory Kasimov commented, Todays PR is expectedly light on details, so well have to wait for ASCO to get the full picture. In our view, the future of neratinib in this indication largely rests on the nuances of the data, namely: 1) the magnitude of benefit, 2) the subgroups that drive this benefit (HR+ and/or HR-), and 3) details of the safety profile. The ultimate impact on Puma remains to be seen, but this outcome has obviously taken the near-term best-case scenario off the table. Our prevailing expectation was that on positive APHINITY results, PBYI shares could initially lose roughly 1/3 of their value. That said, investor feedback weve been getting has suggested that this potential dip could provide an opportunity ahead of the ASCO details as well as a number of pending neratinib data points in 1H17.

Out of the 8 analysts polled by TipRanks (in the past 12 months), 6 rate Puma Biotechnology stock a Buy, while 2 rate the stock a Hold. With a return potential of 180%, the stocks consensus target price stands at $79.

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Thursday's Biotech Insights: Aurinia Pharmaceuticals Inc (AUPH), Puma Biotechnology Inc (PBYI) - Smarter Analyst

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Diabetes Smackdown seminar – Kozi Radio

Posted: March 6, 2017 at 2:43 am

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Diabetes Smackdown seminar - Kozi Radio

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