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Dutch Biopharma launches Phase III trial of Leukemia donor cell therapy – BioPharma-Reporter.com

Posted: February 14, 2017 at 10:42 am

Amsterdam-based Kiadis Biopharma has received Health Canada approval to initiate a global Phase III trial for an allogenic stem cell therapy for acute leukemia.

Kiadis cell therapy, ATIR101 (Allodepleted T-cell ImmunotheRapeutics) is a modified infusion of a family members donated lymphocytes Kiadis is developing to treat leukemia.

By treating the donor cells, the firm looks to reduce the risk of the patient developing severe Graft-versus-Host-Disease, a life-threatening immune response.

Using the contract research organisation (CRO) CTI Clinical Trial and Consulting Services Inc., the trial will enrol 195 patients across 40-50 clinical sites, including the US and Canada.

Kiadis has since submitted the trial protocol to the US FDA and several European regulators, with anticipated launch of ATIR101 in 2018.

The contract manufacturing organisation PCT LLC has been partnered with Kiadis for producing ATIR101 for the US and Canada since June last year, using PCTs Allendale, New Jersey facility.

For the European supply of the therapy, Kiadis will continue to work with the German Red Cross Blood Donor Service, Baden-Wrttemberg-Hessen e.V.,which provided GMP manufacturing services for the Phase II trial of ATIR101.

Manfred Rdiger, CEO of Kiadis Pharma said We have significant momentum now and the preparation of our MAA submission to EMA is progressing well.

Kiadis declined to comment further.

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Clinical cell therapy guidelines for neurorestoration (China version 2016) – Dove Medical Press

Posted: February 14, 2017 at 10:42 am

Hongyun Huang,1 Lin Chen,2 Qingyan Zou,3 Fabin Han,4 Tiansheng Sun,5 Gengsheng Mao,1 Xijing He6

1Institute of Neurorestoratology, General Hospital of Armed Police Forces, 2Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, 3Guangdong 999 Brain Hospital, Guangzhou, 4Centre for Stem Cells and Regenerative Medicine, Affiliated Hospital of Taishan Medical University, Liaocheng, Shandong, 5Department of Orthopedics, Beijing Army General Hospital, Beijing, 6Second Department of Orthopedics, The Second Affiliated Hospital of Xian Jiaotong University, Xian, Peoples Republic of China

On behalf of the Chinese Association of Neurorestoratology and Chinese Branch of the International Association of Neurorestoratology

Abstract: Cell therapy has been shown to be a key clinical therapeutic option for central nervous system disease or damage, and >30 types of cells have been identified through preclinical studies as having the capacity for neurorestoration. To standardize the clinical procedures of cell therapy as one of the strategies for treating neurological disorders, the first set of guidelines governing the clinical application of neurorestoration was completed in 2011 by the Chinese Branch of the International Association of Neurorestoratology. Given the rapidly advancing state of the field, the Neurorestoratology Professional Committee of Chinese Medical Doctor Association (Chinese Association of Neurorestoratology) and the Chinese Branch of the International Association of Neurorestoratology have approved the current version known as the Clinical Cell Therapy Guidelines for Neurorestoration (China Version 2016). We hope this guideline will reflect the most recent results demonstrated in preclinical research, transnational studies, and evidence-based clinical studies, as well as guide clinical practice in applying cell therapy for neurorestoration.

Keywords: cell therapy, neurorestoration, China, clinical application

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Real Madrid’s Nacho Fernandez feared diabetes would end football dreams – ESPN FC

Posted: February 14, 2017 at 10:42 am

Nacho Fernandez came through the ranks at Real Madrid.

Real Madrid defender Nacho Fernandez has said he was told at the age of 12 that he would not be able to have a career in football because of his type one diabetes.

Nacho, 27, made his 100th senior appearance for the Liga leaders in Saturday's win at Osasuna.

But it once seemed his dream of playing professionally would never happen, he told UEFA in quotes reported by Madrid's official website.

"I had been playing for two years at Real Madrid and it was a tough time," he said. "I remember, when I went into the hospital, the doctor who saw me wasn't the one who should have seen me.

"That doctor told me that I couldn't continue playing football and it was a really bad weekend for me.

"But three days later I saw Dr Ramirez, someone I'm very fond of. He told me the opposite -- that I had not finished with football at all."

Asked whether being diabetic meant there were limits on what he could do, Nacho said: "I am lucky to play football, I like to play all kinds of sports, exactly because of that, because it is very important to do physical activity.

"I have no limitations. There are meals that I have to be a little more careful with but I eat everything and I am lucky to have it well controlled.

"It makes you be a more responsible person and take more care of yourself."

Nacho has spent his whole career at the Bernabeu after coming through the ranks and said that meant "you know that when you wear this shirt you have that responsibility."

"You are playing for the best team in the world and, from a young age, you are learning things that the club teaches you," he added.

"When you reach the first team, the dimensions are much greater and people look at you through a magnifying glass."

He praised coach Zinedine Zidane, saying he was doing "a very good job."

"I like him because he's a bit like me, a quiet person that does not get bothered when a problem comes along," he said. "Thanks to him we have achieved important things, and I hope it continues this way."

Dermot Corrigan is a Madrid-based football writer who covers La Liga and the Spain national team for ESPN FC. Follow him on Twitter @dermotmcorrigan

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Study: Air Pollution & Heightened Risk Of Type 2 Diabetes Tied Together (In Obese Latino Children, & Possibly Others … – CleanTechnica

Posted: February 14, 2017 at 10:42 am

Published on February 14th, 2017 | by James Ayre

February 14th, 2017 by James Ayre

A new study led by USC researchers has found that Latino children who live in places with high levels of air pollution are more likely to develop Type 2 diabetes as a result of high levels of air pollution apparently working to make insulin-creating cells less efficient.

While the research was focused solely on low-income Latino children, the findings are very likely to have relevance to others living in areas with high levels of air pollution in particular, in areas with high levels of nitrogen dioxide (NOx) and particulate matter 2.5 (PM2.5) in the air, the pollutants that were especially high in the regions in question.

Exposure to heightened air pollution during childhood increases the risk for Hispanic children to become obese and, independent of that, to also develop Type 2 diabetes, stated Michael Goran, co-director of the Diabetes and Obesity Research Institute at the Keck School of Medicine of USC. Poor air quality appears to be a catalyst for obesity and diabetes in children, but the conditions probably are forged via different pathways.

The press release provides more:

Scientists tracked childrens health and respective levels of residential air pollution for about 3.5 years before associating chronic unhealthy air exposure to a breakdown in beta cells, special pancreatic cells that secrete insulin and maintain the appropriate sugar level in the bloodstream.

By the time the children turned 18, their insulin-creating pancreatic cells were 13% less efficient than normal, making these individuals more prone to eventually developing Type 2 diabetes, researchers said.

Additionally, as might be expected, the fully functioning beta cells were overworking themselves to make up for the less efficient ones, but then that burns them out. Going on:

As the cells failed to secrete insulin efficiently, regulation of sugar in the bloodstream overwhelmed the system, heightening the risk of Type 2 diabetes.

Each year the participants fasted and then came to the Childhood Obesity Research Center at USC for a physical exam and to have their glucose and insulin levels measured over a span of 2 hours. When they turned 18, the participants had nearly 27% higher blood insulin after having fasted for 12 hours. During their 2-hour glucose test, they had about 36% more insulin than normal, indicating that the body was becoming less responsive to insulin. This observation illustrated that increased exposure to air pollution was associated with increased risk factors for Type 2 diabetes.

Interestingly, when the data was adjusted for socioeconomic status and body fat, the effect of long-term exposure to air pollution (as measured at age 18) was greater than that of a 5% gain in body weight. Thats pretty amazing, and makes it clear that the modern diabetes epidemic is notsimply a matter of drinking too much branded sugar water.

Using data provided by the Centers for Disease Control and Prevention, we can see that diabetes occurrence in the US has roughly quadrupled during just the last 4 decades. If this trend was to continue, then 1 out of every 3 US residents would have diabetes by 2050. Thats 1 out of every 3 US residents, not just 1 out of every 3 adult residents kids, babies, everyone.

Diabetes is occurring in epidemic proportion in the US and the developed world, commented Frank Gilliland, senior author and a professor of preventive medicine at the Keck School of Medicine. It has been the conventional wisdom that this increase in diabetes is the result of an uptick in obesity due to sedentary lifespans and calorie-dense diets. Our study shows air pollution also contributes to Type 2 diabetes risk.

It should probably be noted here that there are an estimated ~8.1 million people in the US whohave diabetes buthavent been diagnosed for whatever reasons. So, essentially, roughly 28% of people who have diabetes in the US may not know it (having not been diagnosed by a medical professional).

The new research was published in the journal Diabetes.

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Tags: air pollution, diabetes, NOx, PM 2.5, USC

James Ayre 's background is predominantly in geopolitics and history, but he has an obsessive interest in pretty much everything. After an early life spent in the Imperial Free City of Dortmund, James followed the river Ruhr to Cofbuokheim, where he attended the University of Astnide. And where he also briefly considered entering the coal mining business. He currently writes for a living, on a broad variety of subjects, ranging from science, to politics, to military history, to renewable energy. You can follow his work on Google+.

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Study: Air Pollution & Heightened Risk Of Type 2 Diabetes Tied Together (In Obese Latino Children, & Possibly Others ... - CleanTechnica

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Nurse’s Notes: The state of diabetes in America – The Missoulian

Posted: February 14, 2017 at 10:42 am

A recent study reported that diabetes is the third leading cause of death in the United States, up from seventh in 2010.

This study also reported that life expectancy has slowed down or even decreased, mainly due to the rise of diabetes and obesity in our country. Per recent Centers for Disease Control statistics, 21.95 million people in the United States, or 9.3 percent of the population, in 2014 had diabetes. In those 65 years old and older, more than 25 percent have diabetes, and that percentage is expected to double by 2050 if current trends continue.

If glucose levels are high over long periods of time, heart disease, blindness, kidney disease, nerve damage and other complications can result. But prevention of these complications is possible. The American Diabetes Association recommends that most non-pregnant adults with diabetes maintain a hemoglobin A1c (a 3-month blood sugar average) less than 7 percent, with daily blood sugars less than 130 mg/dl after fasting and less than 180 mg/dl two hours after eating.

Diabetes costs $245 billion a year; $69 billion of those costs are indirect, such as lost productivity and increased absenteeism from work. Patients with diabetes have medical costs twice as much as those without diabetes. The risk of death in adults with diabetes is 50 percent higher than for adults without diabetes. Prediabetes (often a precursor to type 2 diabetes) currently has a prevalence of 86 million, or 30 percent of the population, and nine out of 10 of those folks are unaware they have it. In the Medicare population, more than half have prediabetes, based on estimates from the Centers for Disease Control.

Recent statistics estimate that 90 percent of the cases of type 2 diabetes can be prevented through lifestyle change, specifically Diabetes Prevention Programs. Structured DPPs are effective interventions lasting one year and taught by a lifestyle coach. Participants in the DPP learn about healthy eating, ways to incorporate exercise, how to manage stress and set up their environment and life for success.

The goal of the DPP is to have participants lose 7 percent of their body weight over the course of a year through nutrition interventions and exercising at least 150 minutes per week. The results from the DPP suggest over a 50 percent reduction in acquiring type 2 diabetes for those at risk. In 2018, Medicare will pay for the DPP as long as the program goes through the CDC accreditation process.

The potential is there to slow the rate of type 2 diabetes in our country. If you or someone you love is concerned about having prediabetes, ask your doctor to do a simple blood test such as a hemoglobin A1C or take the CDC risk test found at cdc.gov/diabetes/prevention/pdf/prediabetestest.pdf.

We can turn the tide of diabetes in our country by screening all people with risk factors for diabetes and getting them into a DPP. Such opportunities exist in Missoula and Western Montana. As Robert Ratner, M.D., chief scientific officer for the American Diabetes Association once said, We must prevent diabetes or our health system will be consumed by it. Now is the time!

Jennifer Troupe, MS, RD, is the manager of Providence Endocrinology, Diabetes and Nutrition Center

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Diabetes in your DNA? Scientists zero in on the genetic signature of risk – Medical Xpress

Posted: February 14, 2017 at 10:42 am

February 13, 2017 A depiction of the double helical structure of DNA. Its four coding units (A, T, C, G) are color-coded in pink, orange, purple and yellow. Credit: NHGRI

Why do some people get Type 2 diabetes, while others who live the same lifestyle never do?

For decades, scientists have tried to solve this mystery - and have found more than 80 tiny DNA differences that seem to raise the risk of the disease in some people, or protect others from the damagingly high levels of blood sugar that are its hallmark.

But no one "Type 2 diabetes signature" has emerged from this search.

Now, a team of scientists has reported a discovery that might explain how multiple genetic flaws can lead to the same disease.

They've identified something that some of those diabetes-linked genetic defects have in common: they seem to change the way certain cells in the pancreas "read" their genes.

The discovery could eventually help lead to more personalized treatments for diabetes. But for now, it's the first demonstration that many Type 2 diabetes-linked DNA changes have to do with the same DNA-reading molecule. Called Regulatory Factor X, or RFX, it's a master regulator for a number of genes.

The team reporting the findings in a new paper in the Proceedings of the National Academy of Sciences comes from the University of Michigan, National Institutes of Health, Jackson Laboratory for Genomic Medicine, University of North Carolina, and the University of Southern California.

They report that many diabetes-linked DNA changes affect the ability of RFX to bind to specific locations in the genomes of pancreas cell clusters called islets. And that in turn changes the cells' ability to carry out important functions.

Islets contain the cells that make hormones, including insulin and glucagon, which keep blood sugar balanced in healthy people. In people with diabetes, that regulation goes awry - leading to a range of health problems that can develop over many years.

"We have found that many of the subtle DNA spelling differences that increase risk of Type 2 diabetes appear to disrupt a common regulatory grammar in islet cells," says Stephen C.J. Parker, Ph.D., an assistant professor of computational medicine and bioinformatics, and of human genetics, at the U-M Medical School. "RFX is probably unable to read the misspelled words, and this disruption of regulatory grammar plays a significant role in the genetic risk of Type 2 diabetes."

Parker is one of four co-senior authors on the paper, which also includes Michael Boehnke, Ph.D., of the U-M School of Public Health's Department of Biostatistics, Francis Collins, M.D., Ph.D., director of the National Institutes of Health, and Michael L. Stitzel, Ph.D. of the Jackson Laboratory.

Prior to their current faculty positions Parker and Stitzel worked in Collins' lab at the National Human Genome Research Institute. Parker's graduate student, Arushi Varshney, is one of the paper's co-first authors with Laura Scott, Ph.D., and Ryan Welch, Ph.D., of the U-M School of Public Health's Department of Biostatistics and Michael Erdos, Ph.D., of the National Human Genome Research Institute.

They performed an extensive examination of DNA from islet samples isolated from 112 people. They characterized differences not just in DNA sequences, but also in the way DNA was packaged and modified by epigenetic factors, and the levels of gene expression products that indicated how often the genes had been read and transcribed.

This allowed them to track the "footprints" that RFX and other transcription factors leave on packaged DNA after they have done their job.

RFX and other factors don't bind directly to the part of a gene that encodes a protein that does a cellular job. Rather, they bind to a stretch of DNA near the gene - a runway of sorts.

But when genetic changes linked to Type 2 diabetes are present, that runway gets disrupted, and RFX can't bind as it should.

Each DNA change might alter this binding in a different way, leading to a slightly different effect on Type 2 diabetes risk or blood sugar regulation. But the common factor for many of these changes was its effect on the area where RFX is predicted to bind, in the cells of pancreatic islets.

So, says Parker, this shows how the genome - the actual sequence of DNAcan influence the epigenome, or the factors that influence gene expression.

The researchers note that a deadly form of diabetes seen in a handful of babies born each year may be related to RFX mutations. That condition, called Mitchell-Riley syndrome, involves neonatal diabetes and malformed pancreas, and is known to be caused by a rare autosomal recessive mutation of one form of RFX.

Explore further: Unique mapping of methylome in insulin-producing islets

More information: Genetic regulatory signatures underlying islet gene expression and type 2 diabetes, PNAS, http://www.pnas.org/cgi/doi/10.1073/pnas.1621192114

Throughout our lives, our genes are affected by the way we live. Diet, exercise, age and diseases create imprints that are stored in something called methylome. Now, for the first time, researchers at the Lund University ...

Variations in non-coding sections of the genome might be important contributors to type 2 diabetes risk, according to a new study.

Problems with insulin secretion experienced by people with Type 2 diabetes, parallel similar problems with insulin-secreting beta cells in many individuals with Down syndrome. A new study, published on May 19 in PLOS Genetics ...

Personalized treatment for people with diabetes could be a step closer after researchers discovered how a single gene mutation fundamentally alters pancreatic development.

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Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have discovered a new protein that may play a critical role in how the human body regulates blood sugar levels. Reporting ...

Why do some people get Type 2 diabetes, while others who live the same lifestyle never do?

It is now possible to reprogram cells from the liver into the precursor cells that give rise to the pancreas by altering the activity of a single gene. A team of researchers at the Max Delbrck Center for Molecular Medicine ...

Keeping blood sugar levels within a safe range is key to managing both type 1 and type 2 diabetes. In a new finding that could lead to fewer complications for diabetes patients, Yale School of Medicine researchers have found ...

Latino children who live in areas with higher levels of air pollution have a heightened risk of developing Type 2 diabetes, according to a new USC-led study.

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DAR Awards Tea honors local youths, diabetes coalition president – The Gleaner

Posted: February 14, 2017 at 10:42 am

John Marshall, Natalie Haley and Maleeyah Grumbs were honored at Saturday's DAR tea.(Photo: Beth Smith)

Henderson County high school student Maleeyah Gumbs had one piece of information -- the topic of the essay.

With that, the 17-year-old senior sat down and composed an award winning essay entitled, "How Do the Combined Actions of Many Good Citizens Keep Our Nation Moving Forward."

Gumbs, the daughter of Angelyn Gumbs, was honored Saturday for her essay by the Daughters of the American Revolution General Samuel Hopkins Chapter. The essay alone wouldn't be enough though to present her with the Good Citizen Award. In fact, Gumbs was also honored forliving as an example of a good citizen through activities such as being part of the Family, Career and Community Leaders of America, Colonelette Dance Team, Rise and Mentor, and being an active member of her youth group at First United Methodist Church.

"I didn't get the topic until I was in the room and about to write the essay," she said. "I was nervous."

"I was surprised," Gumbs said when she was notified that she'd won the award.

Gumbs was one of three Henderson County residents to be lauded by the DAR at the organization's 121st annual tea and award ceremony.

Natalie Haley, an eighth-grader at Holy Name School and the daughter of Tracy and Jenny Haley, was named the winner of the American History Essay.

The topic of Haley's essay was "Celebrating a Century: America's National Parks" which worked out well since she visited Yellowstone National Park for fall break in October of 2016.

Haley said her favorite part of the trip to Yellowstone was visiting "the hot springs. They smelled like sulphur. I didn't like that part because it didn't smell very good, but they are really pretty, and I got a lot of good pics."

The HNS student said winningthe American History Essay Award was a "surprise, because our whole class had done it and there's a lot of good writers in the class. It's such an honor to win."

Finally on Saturday, the DAR presented John Marshall, a local pharmacist and president of the Henderson County Diabetes Coalition, with the Community Service Award.

In presenting the award, Karen Goldie, the chairman of the community service committee, said that Marshall has volunteered many hours with the diabetes coalition which exists "to advocate, educate and support those with diabetes."

He has also spent numerous hours, she said, volunteering with the Hunting Down Diabetes 10K run and the 5K run/walk.

"John has worked many hours on this run. He's been diligent about signing people up as sponsors, arranging for awards and countless other tasks too numerous to even detail here ... He rolls with the punches. If there are any problems, he works through them and keeps going."

Marshall is also a Lions Club member and serves during the club's auction and the Arts and Crafts Fair.

"I was floored to receive this award," Marshall said. "I never really thought I was ever really considered for it."

Working with the diabetes coalition, he said, "is a passion. I want to help people find ways to pay for their insulin and diabetic supplies and to work with the kids (with diabetes) and make sure they have everything they need."

Read or Share this story: http://www.thegleaner.com/story/news/2017/02/13/dar-awards-tea-honors-local-youths-diabetes-coalition-president/97844860/

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Ballplayer’s sacrifice saves his little sister – Rio Rancho Observer

Posted: February 13, 2017 at 4:44 am

Rio Rancho High School senior baseball standout Garrett Gouldsmith knows the meaning of sacrifice, not only as it pertains to baseball but also in life.

You see, Gouldsmith, 17, once donated bone marrow to his younger sister Gabby (now 13 and a student at Lincoln Middle School); that sacrifice saved her life. The family was living in Reno at the time; Buddy and Heather Gouldsmith moved their family to Rio Rancho in August 2015.

Five years ago my sister was diagnosed with severe aplastic anemia, he said, sounding like Doogie Howser.

Aplastic anemia occurs when bone marrow does not produce enough stem cells due to damage. These stem cells develop into the different types of blood cells, including red blood cells, which deliver oxygen to other cells of the body. Mild to moderate cases may not need treatment, but severe cases may result in death and require emergency care.

It is genetic, Gouldsmith said. Its a one-in-five million chance of developing this. It is a super-rare disorder.

Originally, there wasnt really a plan for her treatment, other than a sibling bone marrow (transplant), and they had to be a perfect seven-out-of-seven HLA (human leukocyte antigen) match, which basically means that they have to have the same seven blood-marker identifiers.

So me and my brother (Gunner) got tested. Gunner was a six-out-of-seven match; I was a seven-out-of-seven match, which was a major blessing, a dream come true, he said. So about a week later, after they went through some testing and I finished up playing in Little League districts, I went and donated bone marrow on July 15, 2011. And that was after she went through her rigorous chemo treatment.

After she received the bone marrow, her numbers in terms of T cells, her white blood cells, her red-blood cells all the numbers started to go up, he explained. Everythings been going in a positive way and this past December, right before Christmas, we got the greatest Christmas present of all time: She was officially considered out of remission and cured.

If the baseball future pales, he said, theres no plan to enter the medical field: It was five years of talking about this stuff every single day, he said, that led to his expertise on the subject.

What about that bone marrow donation?

In terms of my baseball career, Id take my sisters life over my baseball career every single day, Gouldsmith said. At the time, it was just, Hey, lets do what we have to do to so that my sister can get healthy again and we can get back to as normal a life as possible.

I was sedated for about two-and-a-half, three hours, he recalled. The treatment itself is three little tiny holes in your lower back, and then they fan with a needle about 150 times in each hole and extract bone marrow.

Being sedated at the time, the bone-marrow removal was painless, but, he said, I felt it later, for about the next week.

After they do that, they put it in a little bag, send it off in an ambulance to a lab so they can do what they need to do in terms of filtering it, he said. And then its put into an IV bag and it just goes into her like an IV.

At the time, back in Nevada, She lost all her hair; she had to wear a mask for the better part of two years, wherever she went, he said. Inside, in terms of our house lifestyle, she could only eat certain foods, if it was packaged, frozen.

The survival rate for patients with aplastic anemia under age 20 who have a bone marrow or stem cell transplant is 80 percent, according to St. Jude Childrens Research Hospital.

With that nightmare and its happy ending behind him, Gouldsmith said hed love to get back to the Class 6A championship game at Isotopes Park in what would be his final game as a Ram.

Thats where he played his last game with the Rams, stranded on second base in the bottom of the ninth, the potential tying run when Wille Baez looked at a third strike to end the extra-inning 2-1 loss to Carlsbad.

The 2016 season was Gouldsmiths first in New Mexico, but it wont be his last: He was an early signer to play at the University of New Mexico, where his father is an assistant coach. Last years District 1-6A Player of the Year, he said he chose UNM over Nevada (back in his hometown of Reno), UCLA and Arizona because of the Lobos success on the field and their success in developing players and moving them on to the next level.

Thats right: Gouldsmith would love to play Major League Baseball, like his shortstop idol, Derek Jeter.

We play the same position, Gouldsmith said. I love the way he did things, both on and off the field. He kept to himself, stayed out of trouble off the field and was a superstar on the field.

Obviously, we dont have the same body type (The Lobos list their recruit at 5-foot-9, 160 lbs.), he said, then likening himself to Houston Astros shortstop Jose Altuve (5-6, 165; the shortest player in the majors).

Murphy and Gouldsmith are thankful the season opener is still a few weeks away (Feb. 23 in El Paso; the starting shortstop was injured at of all places a Lobo baseball camp.

Playing in a scrimmage, I just dove for a backhand, he explained. I didnt think anything of it at the time. I originally came out of the game because I jammed my thumb diving for that ball.

I just kind of sat out, then went home and tried to grab a water out of the fridge and couldnt lift my left arm, he said. Doctor said that nothing surgical needs to go on so I just have to give it some time before we head off to El Paso for our first tournament of the year.

Gouldsmith was expected to get the doctors clearance to practice and play this past Thursday.

Gouldsmith knows theres a lot of hard work ahead of him, to make that MLB dream come true.

Murphy terms him the best five-tool player hes ever had, although Gouldsmith downplays the power tool of that description.

He batted .562 with three home runs, 12 doubles and five triples, with just three errors in 108 total chances.

My goal for this season, obviously, is to win a state championship, but over and above that is to raise money to give back to the community for all the help they gave us and our family during that time.

My plan for this season, to kind of give back to the community in ways the community gave to us when we were going through this, is to have people donate money in terms of a pledge donation or just a flat donation for every base I steal to the Jessie Rees Foundation (negu.org).

(Jessie Rees was a beautiful, athletic, smart and compassionate 12-year-old girl who bravely fought two brain tumors for 10 months and two days. Her fight started March 3, 2011, and ended Jan. 5, 2012, when she lost her battle. During her courageous fight, Jessie decided to focus on helping other kids fighting cancer that couldnt leave the hospital.)

Their phase is Never Ever Give Up, he said. (Ill) donate all the proceeds I receive to them.

Our plan is to, obviously, respect the game first (He sounds like Jeter here.) and steal when necessary and helpful to the team first, he said. Our coaching staff and players have been really supportive of what Im trying to do, and Ive been very grateful to them.

Garrett almost lost his sister, Murphy said. It becomes real personal for the whole team, because now it hits home this is one of us.

It makes it that much more important for us to help him out, he said. We tell these kids all the time that playing baseball is a very small part of this program We really pride ourselves in the community work we do work with the policemen, work with the fire department, doing things for people in the community and this is just another way for us to prove that.

Baseballs still a game. There are so many things in life that are so much more important than baseball, like this, Murphy said. This is what we want our kids to learn about. You can use baseball not only to have fun and play the game, maybe get a college scholarship out of it, but you can also use it for a lot of other good things, like this cause.

To contribute to Gouldsmiths Steal 4 Joy fund, make a one-time pledge or pledge-per-stole-base via head coach Ron Murphy at ron.murphy@rrps.net.

Gouldsmith swiped 31 bases last season, but Murphy wont be giving him the green light every time No.8 is on base.

What you have to understand is were not out there, just trying to steal mucho bases, its still underneath my guidelines, me coaching third and the steal sign and the green light.

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ECO VIEWS: Advertising is not just for humans – Tuscaloosa News

Posted: February 13, 2017 at 4:43 am

By Whit Gibbons

Back when a phone booth was where Clark Kent went to don his Superman costume, inside each booth hung a phone directory. At the back of the directory was an alphabetical list of advertisements collectively known as the Yellow Pages. Today, few people have access to printed Yellow Pages. But advertisements are ubiquitous, which means you can still play what I call the Yellow Pages Game.

The rules are simple. How many advertised services and products can you find that parallel activities in nature? In other words, what advertisements targeted for people mirror the actions of plants and animals? A few, such as ads for legal services, are uniquely human, but not many.

We need not look beyond ads for the home to find countless examples. Heating and cooling, home security, house construction, all these are represented in the natural world. Take, for example, air-conditioning. Definitely not restricted to humans. Honeybees are the consummate climate control experts, maintaining the hive at a near constant temperature year-round. During hot weather, selected worker bees place water droplets in the hive and wave their wings in unison. Fanning the hive in that way can lower the temperature several degrees. During winter, workers become heater bees, continually flexing their muscles isometrically to warm the hive.

Home security is essential throughout the plant and animal kingdoms. Honeybees, wasps and hornets are on constant guard against intruders and have the weapons to defend their homes. A plants home is the plant itself, and numerous plants produce toxins or thorns that ward off many of their predators. Sensitive mimosa plants have what is equivalent to an alarm system. When a stem is disturbed by a hungry insect, the leaves can rapidly fold up, which may startle the insect into leaving. Some acacia trees of Africa have an association with ants that live on them and protect the trees from plant-eating insects. The ants attack an invading beetle or aphid that plans to make a meal of acacia leaves. The ants meanwhile get their nutrients from the acacia tree, much like a homeowner might feed his Doberman. Either is a good security system.

Home construction is common to innumerable animals. Honeybees come to mind again, with their elaborate combs of hexagonal cells that serve as storage for honey and for developing larvae and pupae. The American beaver is not to be outdone in home building, with its dams and lodges, and most avian species build something humans would have difficulty duplicating -- bird nests. Prairie dog colonies consist of tunnels, passageways and side chambers, the quintessential underground estate.

And what about advertising itself? Do plants and animals advertise? Absolutely. The phenomenon is all around us. As spring arrives we will see myriad examples in flowers with their colorful displays designed to attract pollinating insects. Lots of fish and lizards are also more brightly colored during mating season. Males of many of the usually drab darters, small fish that have their greatest biodiversity in Alabama, are noted for their spectacular color displays during the breeding season. As with humans, sound is a common advertising tool. Frogs and birds give mating calls in an effort to attract mates. Fireflies, both males and females, use lights to advertise their availability to procreate.

As with our own commercials, false advertising must constantly be guarded against. The deep-sea angler fish produces a light that dangles in front of its mouth and means sure death for a would-be predator trying to grab a morsel in the dark. Pitcher plants use sweet-smelling aromas to lure unsuspecting insects into the trumpet-shaped tube filled with liquid. Bola spiders have their own scam, producing chemicals that mimic the perfume-like pheromones that female moths use to attract mates.

Advertising is a part of life worldwide, and most human merchandise and trades that are advertised are duplicated in nature. Finding analogies can be a fun and enlightening exercise at home or in the classroom.

Whit Gibbons, professor emeritus of ecology, University of Georgia, grew up in Tuscaloosa. He received bachelors and masters degrees from the University of Alabama and his Ph.D. from Michigan State University. Send environmental questions to ecoviews@gmail.com.

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ECO VIEWS: Advertising is not just for humans - Tuscaloosa News

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Large Outflow of Money Witnessed in iShares Nasdaq Biotechnology Index Fund – Highland Mirror

Posted: February 13, 2017 at 4:43 am

iShares Nasdaq Biotechnology Index Fund (IBB) traded higher in the last at $284.75, gaining 0.19 points or 0.07%. From the data available, it can be said that the stock did not make an impact in the money flow department with the net figure coming to be $(-2.92) million. The composite uptick value of $19.32 million was eclipsed by the accrued downtick value of $22.25 million, thereby ensuring the up/down ratio of 0.87. For the week, the shares have posted returns of 0.6%.

iShares Nasdaq Biotechnology is having a Relative Strength Index of 61.82 which indicates the stock is not yet over sold or over bought based on the technical indicators.

Based on the Stock Research reports from financial advisors, there are Analysts recommending as a Strong Buy, and Analysts recommending as a Moderate Buy. Investors should also note that Stock brokerage firms are recommending to Hold the stock for short term. Stock Research experts are recommending to Sell based on the growth. There are Analysts recommending as a Strong Sell.

iShares Nasdaq Biotechnology Index Fund (NASDAQ:IBB) witnessed a decline in the market cap on Friday as its shares dropped 0.07% or 0.19 points. After the session commenced at $284.48, the stock reached the higher end at $285.88 while it hit a low of $283.55. With the volume soaring to 764,100 shares, the last trade was called at $284.37. The company has a 52-week high of $301.8. The company has a market cap of $8,332 million and there are 29,300,000 shares in outstanding. The 52-week low of the share price is $240.3.

The ISHARES NASDAQ BIOTECHNOLOGY INDEX FUND seeks investment results that correspond generally to the price and yield performance, before fees and expenses, of companies primarily engaged in the biotechnology industry, as represented by the NASDAQ Biotechnology Index.

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Large Outflow of Money Witnessed in iShares Nasdaq Biotechnology Index Fund - Highland Mirror

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