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Educational seminar on stem cell therapy to be featured at lunch meeting in Abilene – Salina Post

Posted: February 13, 2017 at 4:40 am

Kansas Regenerative Medicine Center (KRMC) staff will be the guest speakers at the next Healthwise 55 luncheon. Speakers Frank Lyons, MD; John Farley (Founder); and Kate Farley will define stem cells and explain their many therapeutic uses. The KRMC staff will also share how stem cell therapy is a potential alternative to joint replacements or other medical therapies.

The event will be on Thursday, February 23, from noon to 1 p.m. in the Conklin Conference Center at Memorial Hospital, located at 511 N.E. 10th, Abilene. The cost is $5.00 to cover the price of the meal. Please call Michelle McClanahan, MHS Director of Volunteer Services, at (785) 263-6692 by Monday, February 20, to make a reservation.

Healthwise 55 is a luncheon and health information program hosted by the MHS Volunteer Corps. It is open to the public for individuals ages 55 and older. It includes a meal followed by a health care professional(s) speaking on a health-related topic.

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Educational seminar on stem cell therapy to be featured at lunch meeting in Abilene - Salina Post

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Can banking baby teeth treat diabetes? – Fox News

Posted: February 13, 2017 at 4:40 am

When she was just 11 months old, Billie Sue Wozniaks daughter Juno was diagnosed with type 1 diabetes, an autoimmune disease that affects 1.25 million people and approximately 200,000 children under age 20 in the United States.

The disease had affected several members of Billie Sues family, including her uncle, who passed away at the age of 30.

My first thought was, Her life is going to be short, the 38-year-old from Reno, Nevada recalled. The more that I learned, the more I found that many people with type 1 live longer and the treatment advances are really exciting.

While looking for treatments, Wozniak learned about encapsulation therapy, in which an encapsulated device containing insulin-producing islet cells derived from stem cells is implanted under the skin. The encapsulation device is designed to protect the cells from an autoimmune attack and may help people produce their own insulin.

After learning of the therapy through JDRF, Wozniak saw an ad on Facebook for Store-A-Tooth, a company that offers dental stem cell banking. She decided to move forward with the stem cell banking, just in case the encapsulation device became an option for Juno.

In March 2016, a dentist extracted four of Junos teeth, and sent them to a lab so her stem cells could be cryopreserved. Wozniak plans to bank the stem cells from Junos molars as well.

Its a riskI dont know for sure if it will work out, Wozniak said.

Dental stem cells: a future of possibilities

For years, stem cells from umbilical cord blood and bone marrow have been used to treat blood and bone marrow diseases, blood cancers and metabolic and immune disorders.

Although there is the potential for dental stem cells to be used in the same way, researchers are only beginning to delve into the possibilities.

Dental stem cells are not science fiction, said Dr. Jade Miller, president of the American Academy of Pediatric Dentistry. I think at some point in time, were going to see dental stem cells used by dentistson a daily practice.

Dental stem cells have the potential to produce dental tissue, bone, cartilage and muscle. They may be used to repair cavities, fix a tooth damaged from periodontal disease or bone loss, or even grow a tooth instead of using dental implants.

In fact, stem cells can be used to repair cracks in teeth and cavities, according to a recent mouse study published in the journal Scientific Reports.

Theres also some evidence that dental stem cells can produce nerve tissue, which might eliminate the need for root canals. A recent study out of Tufts University found that a collagen-based biomaterial used to deliver stem cells to the inside of damaged teeth can regenerate dental pulp-like tissues.

Dental stem cells may even be able to treat neurological disorders, spinal cord and traumatic brain injuries.

I believe those are the kinds of applications that will be the first uses of these cells, said Dr. Peter Verlander, Chief Scientific Officer for Store-A-Tooth.

When it comes to treating diseases like type 1 diabetes, dental stem cells also show promise. In fact, a study in the Journal of Dental Research found that dental stem cells were able to form islet-like aggregates that produce insulin.

Unlike umbilical cord blood where theres one chance to collect stem cells, dental stem cells can be collected from several teeth. Also, gathering stem cells from bone marrow requires invasive surgery and risk, and it can be painful and costly.

The stem cells found in baby teeth, known as mesenchymal cells, are similar to those found in other parts of the body, but not identical.

There are differences in these cells, depending on where they come from, Verlander said.

Whats more, mesenchymal stem cells themselves differ from hematopoietic, or blood-forming stem cells. Unlike hematopoietic stem cells, mesenchymal stem cells can expand.

From one tooth, we expect to generate hundreds of billions of cells, Verlander said.

Yet the use of dental stem cells is not without risks. For example, theres evidence that tumors can develop when stem cells are transplanted. Theres also a chance of an immune rejection, but this is less likely if a person uses his own stem cells, Miller said.

The process for banking stem cells from baby teeth is relatively simple. A dentist extracts the childs teeth when one-third of the root remains and the stem cells are still viable. Once the teeth are shipped and received, the cells are extracted, grown and cryopreserved.

Store-A-Tooths fees include a one-time payment of $1,749 and $120 per year for storage, in addition to the dentists fees for extraction.

For families who are interested in banking dental stem cells, they should know that theyre not necessarily a replacement for cord blood banking or bone marrow stem cells.

Theyre not interchangeable, we think of them as complementary, Verlander said.

Although the future is unclear for Junowho was born in 2008her mom is optimistic that shell be able to use the stem cells for herself and if not, someone else.

Ultimately, however, Wozniak hopes that if dental stem cells arent the answer, there will be a biological cure for type 1 diabetes.

I hold out hope that somewhere, someone is going to crack the code, she said.

Julie Revelant is a health journalist and a consultant who provides content marketing and copywriting services for the healthcare industry. She's also a mom of two. Learn more about Julie at revelantwriting.com.

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Local doctors encouraged by new diabetes treatment – SFGate

Posted: February 13, 2017 at 4:40 am

In this Wednesday, Jan. 11, 2017 photo, diabetes educator Kimberly P. Miller, BSN, RN, CDE, holds a Medtronic Minimed diabetes insulin pump in her office at CHI Memorial, in Chattanooga, Tenn. (Tim Barber/Chattanooga Times Free Press via AP) less In this Wednesday, Jan. 11, 2017 photo, diabetes educator Kimberly P. Miller, BSN, RN, CDE, holds a Medtronic Minimed diabetes insulin pump in her office at CHI Memorial, in Chattanooga, Tenn. (Tim ... more Photo: Tim Barber, AP In this Wednesday, Jan. 11, 2017 photo, diabetes educator Kimberly P. Miller, BSN, RN, CDE, talks about location options for new diabetes insulin pumps in her office at CHI Memorial, in Chattanooga, Tenn. (Tim Barber/Chattanooga Times Free Press via AP) less In this Wednesday, Jan. 11, 2017 photo, diabetes educator Kimberly P. Miller, BSN, RN, CDE, talks about location options for new diabetes insulin pumps in her office at CHI Memorial, in Chattanooga, Tenn. (Tim ... more Photo: Tim Barber, AP In this Wednesday, Jan. 11, 2017 photo, diabetes educator Kimberly P. Miller, BSN, RN, CDE, holds a Medtronic Minimed diabetes insulin pump in her office at CHI Memorial, in Chattanooga, Tenn. (Tim Barber/Chattanooga Times Free Press via AP) less In this Wednesday, Jan. 11, 2017 photo, diabetes educator Kimberly P. Miller, BSN, RN, CDE, holds a Medtronic Minimed diabetes insulin pump in her office at CHI Memorial, in Chattanooga, Tenn. (Tim ... more Photo: Tim Barber, AP

Local doctors encouraged by new diabetes treatment

CLARKSVILLE, Tenn. (AP) While the number of Tennesseans fighting diabetes continues to grow, doctors are encouraged by new treatment options they say may help prevent, or at least lessen, the impact of the chronic disease.

About 9 percent of the U.S. population has diabetes but the rate in Tennessee is close to 15 percent, said Kimberly Miller, a nurse and diabetes educator in CHI Memorial's Diabetes and Nutrition Center. Tennesseans are fatter than the national average and get less exercise, two factors that often lead to Type 2 diabetes, the most common form of the disease.

Untreated, diabetes can cause eye, kidney, and heart problems, or even death.

But diabetes specialists hope new technology and improvements in some old-fashioned techniques will help lower the number of people who get the disease and make it easier for those who have it to control their illness.

Diabetes is caused when the body is unable to manufacture sufficient insulin, or becomes resistant to it. Insulin is needed to break down sugars in food to provide energy to the cells in the body.

In its early stages, diabetes can be treated with exercise and changes in diet. But for certain types of diabetics, where the body is producing little or no insulin or has become resistant, a more aggressive approach is needed.

The normal way of treating full-blown diabetes is for patients to inject insulin before every meal and at bedtime. To gauge the proper dose, patients must test their blood sugar levels using a blood sample inserted into a device. Then they must inject insulin through a syringe, normally in the stomach or abdomen.

The process is time-consuming, painful and awkward. But new medical devices show promise for getting rid of at least some of the blood work, although they are not appropriate for all diabetics.

One category of device measures blood sugar levels automatically. The patient wears a patch or has a small tube (a catheter) inserted under the skin that measures blood sugar on a regular basis and transmits readings to a larger piece of equipment that displays the levels.

With a monitor, a patient can see their blood sugar, or glucose, levels rising or falling in time to take preventive action, Miller said. Some devices also transmit data remotely so family members or friends can help monitor patients and call for help if their blood sugar levels are getting out of line and the patient is doing nothing to correct them.

"The devices have been around for some time, but they used to be very inaccurate and difficult to use," said Dr. Ashley Shoemaker, a Vanderbilt University Medical Center professor whose clinic treats some 2,500 diabetic children annually. "Now they have become accurate enough that people are allowed to make medical decisions based on their numbers."

But once the patient gets a reading, he or she still needs to measure the proper amount of insulin and inject it. And until recently, patients also needed to take a blood sample a couple of times a day to be certain the device was working properly, Shoemaker said.

Being able to constantly monitor blood sugar levels is particularly important for people with Type 1 diabetes, sometimes referred to as juvenile diabetes, she said. Type 1 diabetes is rarer than Type 2, occurring in only about 5 percent of the population, but it can be harder to control because the pancreas does not produce any insulin at all, so regulating the insulin level artificially is critical.

Some Type 1 diabetics are now using a pump that can inject insulin on a regular basis. By giving regular small doses instead of irregular large doses, the pump can level out a patient's blood sugar levels.

"They are really small," said Dr. Asma Khan, an endocrinologist and diabetes specialist with Erlanger hospital. "The needle that goes under the skin is very thin, and then there is a tube that goes into the pump, that then goes into their pocket."

But not every patient likes the pump, she said. "Having something attached to their body, for some people that is strange," she said. "Some people feel that an injection is easier than working with the pump, which has buttons, and takes some working with."

The Holy Grail of a self-contained unit that would constantly monitor a patient's blood sugar level and adjust the insulin injections automatically, with no need of calibration, is still several years away, diabetes specialists agreed.

A new device from Medtronics set to go on sale in March, the MiniMed 670G, is getting a lot of attention, because it promises to combine the glucose monitor with the insulin pump. Other manufacturers are expected to offer their own comparable gear in a few months, Shoemaker said.

"I don't think we're that close to a cure or anything that's going to completely take the patient out of the loop," said Vanderbilt's Shoemaker. "As the technology continues to advance, we are hopeful that the human factor will become less and less burdensome."

But University of Tennessee College of Medicine diabetes specialist Dr. Jim Bailey believes that an increased focus on traditional ways of dealing with the disease may have a greater impact, although he wants to combine those old-fashioned ways with a modern twist.

Bailey agrees that devices such as the sensor patch and insulin pump are important for some people whose body is producing no insulin or is rejecting it. But he believes most diabetics should spend more time focusing on their diet and exercise.

"The most important cures for diabetes are ways to support people changing their lifestyle around healthy eating and physical activity," he said. "Those are the only real cures for diabetes."

Bailey knows that if doctors just tell people to eat more broccoli and fewer french fries, it is unlikely that patients will comply they need more incentive to change bad habits. So he has been testing two alternative approaches: one using text messages and the other a live person, a health coach.

First, the patient discusses his goals with his doctor. Then the doctor's office sends out regular text messages, as many as twice a day, asking patients how they are doing in meeting those goals. "They are motivational text messages tailored to the patient's interests," he said, "whether it is working on weight loss and healthy eating or in increasing a patient's activity or in taking their medicines correctly."

The health coaches take a similar approach.

"Doctors only have time for a short little visit and only a little bit of time to work on goal setting and working on lifestyle changes and how patients are taking their medicines," Bailey said. But the health coach can spend much more time with the patient. "What has been shown is that coaches really can help people increase their vegetable intake, decrease sugary food intake, increase their physical activity and get better control of their diabetes and feel better as well," he said.

Early studies have shown that both text messages and health coaches can work. Bailey won a $5 million grant last year to test the two approaches with diabetics in West Tennessee to see which approach works better.

"For the vast majority of diabetics, they can get control of their diabetes without insulin if they have enough support and the ability to change their diet and their physical activity," he said. "But it is hard."

___

Information from: Chattanooga Times Free Press, http://www.timesfreepress.com

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Giving the messages from fat cells a positive spin to prevent diabetes – Science Daily

Posted: February 13, 2017 at 4:40 am


Science Daily
Giving the messages from fat cells a positive spin to prevent diabetes
Science Daily
Losing weight appears to reset the chemical messages that fat cells send to other parts of the body that otherwise would encourage the development of Type 2 diabetes, substantially reducing the risk of that disease, a team led by Children's National ...

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McHenry Culver’s to host fundraiser for diabetes research – Northwest Herald

Posted: February 13, 2017 at 4:40 am

McHENRY The Culvers in McHenry is partnering with JDRF Illinois to host a fundraiser Thursday to help raise money for type 1 diabetes research.

The fundraising event, called The Family Mini Mix Up, will be from 4 to 8 p.m. at 1101 Adams Drive, McHenry.

Along with collecting donations from guests, Culvers will offer specially priced $2 mini concrete mixers, with $1 from each mixer sold benefiting JDRF.

According to the Illinois chapter of JDRF, guests who have dined at Chicago-area Culvers restaurants since mid-January have donated their spare change to the organization.

Were grateful to the entire Culvers team for all of their support and encourage the community to dine with us on Feb. 16, JDRF Illinois Executive Director Mimi Crabtree said. Living with type 1 diabetes is difficult and even life-threatening. Those affected serve as an inspiration by facing the diseases challenges with courage and perseverance, and they dont let it stand in the way of achieving their goals.

McHenry is one of several participating Culvers restaurants across the state. Other participating locations include Island Lake, Arlington Heights and Lake Zurich.

For information about JDRF or type 1 diabetes, visit http://www.jdrf.org.

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California woman with rare cancer to conquer world’s highest free-standing mountain – Fox News

Posted: February 11, 2017 at 5:48 pm

Nancy Dziedzic, of Sacramento, California, enjoyed hiking in her 20s, but she had never tackled any major mountains. Now 51 and more than three years after being diagnosed with a rare blood cancer, Dziedzic is preparing to conquer Mount Kilimanjaro, the highest mountain in Africa, towering at 19,340 feet, and the highest free-standing mountain in the world.

Dziedzic and five other multiple myeloma patients start their 11-day quest on Feb. 17. The Kilimanjaro hike is part of Moving Mountains for Multiple Myeloma, a collaboration between CURE Media Group, Takeda Oncology and the Multiple Myeloma Research Foundation (MMRF). Together, the groups send patients, as well as their family members, caregivers, and myeloma doctors and nurses on hikes with challenging terrain, including the Grand Canyon and Machu Picchu.

Multiple myeloma develops in the plasma cells found in the bone marrow. These plasma cells are critical for maintaining the immune system, but abnormal antibodies turn them into malignant melanoma cells. The cancer typically occurs in the spine, pelvic bones, ribs and areas of the shoulders and hips the bone marrow with the most activity. According to the American Cancer Society, about 30,280 new cases of multiple myeloma will be diagnosed this year, resulting in 12,590 deaths. The lifetime risk of getting multiple myeloma is 1 in 143 (.7 percent).

Dziedzic, who works for the state of California in housing and community development, first heard of Moving Mountains through a Facebook myeloma support group post about the 2016 climb. Because she was doing well on her treatment, her doctor encouraged her to apply, and she was accepted in February.

Id always dreamed of going to Africa, so I was really interested, Dziedzic told Fox News. I followed the trek last year and was really excited and inspired by them.

Dziedzic was diagnosed with multiple myeloma in September 2014 after feeling pain in her midsection. After several months of seeking a diagnosis, doctors identified multiple lesions and fractures on her ribs. These lesions form when groups of myeloma cells cause other cells in the bone marrow to remove the solid part of the bone. They do not occur in all myeloma patients.

After receiving her diagnosis, Dziedzic was immediately admitted to the hospital for about a week and started chemotherapy. Doctors then put her on five months of a three-drug cocktail, including Takedas Velcade, which led to drop in her cancer cells down to negligible amounts. In April 2015, Dziedzic underwent a stem cell transplant to replace healthy cells damaged by chemo, and, four months later, she started on a daily maintenance drug of an oral chemotherapy.

Im in complete response they dont call it remission my levels are at very low, negligible amounts, and havent really changed at all since my stem cell transplant, Dziedzic said. Right now Im feeling pretty normal, as much as you can.

Dziedzics care is now down to blood work once a month and a visit to the oncologist every two months.

The importance of being active

Climbing through the six different ecosystems cultivated areas, rain forest, heath, moorland, alpine desert and the summit of the mountain poses challenges for healthy individuals and even more so for multiple myeloma patients. However, conquering the mountain is possible, and even beneficial, for people like Dziedzic, said Dr. Betsy ODonnell, an oncologist and researcher at Massachusetts General Hospital, and a fellow Kilimanjaro hiker.

Theres nothing to limit Nancy or any of these other climbers in any of their efforts on Kilimanjaro, ODonnell told Fox News. There is tremendous data that exercise is beneficial at any stage of therapy. Its important for patients to engage in physical activity. In her research work, ODonnell often partners with Takeda on clinical trials.A triathlete, she joined the Moving Mountains trip after being contacted by Takeda employees who knew about her active lifestyle.

Takeda manufactures multiple myeloma drugs, including Velcade, a type of chemotherapy thats the standard of care for first-line melanoma treatment, ODonnell said.

Pretty much every patient with a multiple myeloma diagnosis will see it, she said. The standard, backbone therapies come from a handful of drug companies.

While imperative, staying active during treatment for multiple myeloma or any other cancer can also be challenging, noted ODonnell, who is also the director of the Lifestyle Medicine Clinic at Mass General. The American Cancer Association recommends most cancer patients engage in 150 minutes of moderately intense exercise every week, plus two strength and conditioning sessions. Patients should consult their health care providers to ensure their fitness plan is appropriate.

After receiving a diagnosis, patients typically receive the treatment Dziedzic had: a three-drug combination and, depending on the patients age, a stem cell transplant, which requires a high dose of chemotherapy and hospitalization. During that time, doctors encourage patients to walk, but the recovery time after discharge can have a significant impact on patients cardiovascular health.

During the recovery period, where youre mostly at home laying low for a month after, its a long period of time, ODonnell said. On top of that, most multiple myeloma treatments include four to eight months of steroids, which often leads to a loss of lean muscle mass and increased visceral fat.

Taking steroids definitely made a difference, Dziedzic said. I gained weight, and you have these highs and lows because the days youre taking steroids, you are just going 100 percent. Its really hard to sleep on those days, so it disrupts your whole week.

Prior to her diagnosis, Dziedzic walked as her main form of exercise, and skipped the gym when she got sick to avoid exposing her immune system to germs. After she was accepted for the hike, her doctor encouraged her to return to the gym, where shes been working on cardiovascular and strength training, as well as hiking outdoors on the weekend and after work.

Ready for the climb

Once they reach Tanzania, the team will hike from four to six hours a day and will spend a few days doing acclimatization hikes, going up high and then back down to adjust to the altitude.

The 16-member team of patients, family members and supporters includes a mix of ages and fitness levels. Participants costs are fully covered by Takeda and CURE Magazine and the teams fundraising efforts go toward MMRF to fast-track research on multiple myeloma treatments. ODonnell estimated the trip costs $3,000-$4,000 for each hiker, plus transportation and donated gear.

On July 9, 2016, the Kilimanjaro teammates had a practice hike on Mount Bierstadt in Colorado, climbing the 14,065 foot mountain.

Dziedzic hopes her experience will raise awareness and inspire other multiple myeloma patients the way the previous expedition team did for her.

They can resume a normal life, and even do incredible things like climb Kilimanjaro or whatever is in their capabilities, she said. Shell take her first vacation since her stem cell transplant, eight days on safari, after the hike is complete.

Dziedzic is nervous but hopes her training has been enough.

I feel very mentally prepared, and I think thats a big hurdle that in some ways is even more important than the physical, she said. I feel ready mentally for it hopefully my body follows along with that.

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Stem cell Icarus – BioEdge

Posted: February 11, 2017 at 5:47 pm

Landscape with the Fall of Icarus, attributed to Pieter Brueghel the Elder

What happened to the disgraced Italian surgeon who dazzled the world with artificial tracheas built up with stem cells, Paolo Macchiarini? Despite all the hype, several of his patients eventually died; others are still seriously ill. The ensuing debacle dragged Swedens Karolinska Institute into the mire and Swedish police are investigating whether he should be charged with involuntary manslaughter.

At the moment Macchiarini is the head of a research team in bioengineering and regenerative medicine at the University of Kazan, in Tatarstan, about 800 kilometers east of Moscow. But Russian authorities do not allow him to do clinical work. Instead he is confined to doing research on baboons.

Unfortunately, the story of the Italian Icarus is the story of many research projects with stem cells noisily rising and rising and rising and then silently falling out of sight. Very few stem cell therapies have reached stage IV of clinical trials.

As journalist Michael Brooks points out in the BMJ, stem cell research is a field plagued by unrealistic expectations. One study showed that 70% of newspaper articles about stem cell research have stated that clinical applications are just around the corner, in the near future, or within 5 to 10 years or sooner.

This is not simply a problem of media hype, writes Brooks. In a surprisingly large number of cases, the source of these unrealistic expectations can be traced back to the scientists themselves.

Another source of false hope is the very success of some treatments. In clinics all over the world, doctors are using unproven techniques to treat patients and sometime they appear to work. But despite grandiose claims, these successes are not documented properly and could even be spontaneous remissions. There need to be rigorous clinical trials.

A major figure in the growth of the stem cell field, Alan Trounson of the Hudson Institute in Victoria, Australia, who used to head the California Institute for Regenerative Medicine, told Brooks that Fame and fortune is seductive and stem cells is one of those areas which can provide this. Close supervision is needed to keep researchers on the straight and narrow.

Finally, one cause of the stem cell hype is simply pride. The Karolinska succumbed to this temptation. According to its internal investigation, protecting its reputation led to a risk of inadequacies and shortcomings not coming to light.

Perhaps, says Brooks, The Macchiarini affair might have a silver lining for stem cell research as a whole. He quotes a man who should know, Alan Trounson: I believe the field will move on with a little more carewe certainly need to.

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Sequim lab looks to find the best biofuel in algae – The Daily Herald

Posted: February 11, 2017 at 5:47 pm

By MATTHEW NASH

Peninsula Daily News

SEQUIM Scientists at the Pacific Northwest National Laboratorys Marine Sciences Laboratory are turning algae inside out to find the best biofuel possible.

Dr. Michael Huesemann, a lead researcher, said algae is a promising clean energy but expensive to harness effectively.

The price of biofuel is largely tied to growth rates, he said. Our method could help developers find the most productive algae strains more quickly and efficiently.

Huesemann, who has worked with algae for 16 years, started on the $6 million, three-year algae DISCOVR project (Development of Integrated Screening, Cultivar Optimization and Validation Research) in October 2016 with a small team of senior and junior scientists in Sequim, reported the Peninsula Daily News.

What were really interested in are carbon-neutral biofuels that can be grown in the United States, he said.

We havent found any algae that grows fast enough or provides enough biofuel, so were trying to find microalgae that grows fast to make biofuels.

Huesemann said there are millions of strains in nature to sort through, so rather than a shotgun approach and randomly screening they are doing an organized, rational screening.

Finding the best algae is broken into a process of five tiers among labs in Sequim, three other Department of Energy labs Los Alamos National Laboratory, National Renewable Energy Laboratory, Sandia National Laboratories and Arizona State Universitys Arizona Center for Algae Technology and Innovation.

Previously, researchers tried to evaluate algae in test tubes but find lab results dont always mirror outdoor ponds, laboratory officials said.

In Tier I, scientists in Sequim and New Mexico test up to 30 different algae strains to see how weather-tolerant they are, and the top third will go to Tier II, Huesemann said.

In Tier II, Sequim houses a unique climate-simulating system called LEAPS (Laboratory Environmental Algae Pond Simulator) that simulates climates and seasons around the world inside glass cylinder photobioreactors.

Two other labs will evaluate the algae to see if there is any value in its compounds that could be used for products like food dye phycocyanin, which could make algae biofuel production more cost-effective, Huesemann said.

Scientists also will research how resilient certain algae strains are to predators, like protozoans, and other competing algae.

Huesemann anticipates Tier I and II being conducted this year, he said.

For Tier III, researchers in New Mexico will further test top-performing algae strains, Huesemann said, which includes forcing cells to grow faster or generate more oils, using state-of-the-art laboratory techniques such as directed evolution and fluorescence-assisted cell sorting.

Afterward, strains will travel to outdoor ponds in Arizona for study as part of Tier IV to compare biomass output with earlier steps. Lastly, scientists will study the algae strains that performed the best in different lighting and temperature conditions for Tier V.

Data will go into the Pacific Northwest National Laboratories Biomass Assessment Tool to help researchers generate maps that illustrate the expected biomass productivity of each algae species grown in outdoor ponds all over the U.S. in different seasons on any day of the year, Huesemann said.

Once the study is complete, research will be made public for companies and other researchers.

Laboratory officials said work that could stem from this project includes converting harvested algae into biofuels, examining operational changes such as crop rotation to further increase biomass growth and assessing the technical feasibility and economic costs of making biofuel from algae selected through this process.

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Stanford team is growing healthy skin for ill patients – The Mercury News

Posted: February 11, 2017 at 5:47 pm

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Small sheets of healthy skin are being grown from scratch at a Stanford University lab, proof that gene therapy can help heal a rare disease that causes great human suffering.

The precious skin represents growing hope for patients who suffer from the incurable blistering disease epidermolysis bullosa and acceleration of the once-beleaguered field of gene therapy, which strives to cure disease by inserting missing genes into sick cells.

It is pink and healthy. Its tougher. It doesnt blister, said patient and research volunteer Monique Roeder, 33, of Cedar City, Utah, who has received grafts of corrected skin cells, each about the size of an iPhone 5, to cover wounds on her arms.

More than 10,000 human diseases are caused by a single gene defect, and epidermolysis bullosa is among the most devastating. Patients lack a critical protein that binds the layers of skin together. Without this protein, the skin tears apart, causing severe pain, infection, disfigurement and in many cases, early death from an aggressive form of skin cancer.

The corrected skin is part of a pipeline of potential gene therapies at Stanfords new Center for Definitive and Curative Medicine, announced last week.

The center, a new joint initiative of Stanford Healthcare, Stanford Childrens Health, and the Stanford School of Medicine, is designed to accelerate cellular therapies at the universitys state-of-the-art manufacturing facility on Palo Altos California Avenue. Simultaneously, itisaiming to bring cures to patients faster than before and boost the financial value of Stanfords discoveries before theyre licensed out to biotech companies.

With trials such as these, we are entering a new era in medicine, said Dr. Lloyd B. Minor, dean of the Stanford University School of Medicine.

Gene therapy was dealt a major setback in 1999 when Jesse Gelsinger, an Arizona teenager with a genetic liver disease, had a fatal reaction to the virus that scientists had used to insert a corrective gene.

But current trials are safer, more precise and build on better basic understanding. Stanford is also using gene therapy to target other diseases, such as sickle cell anemia and beta thalassemia,a blood disorder that reduces the production of hemoglobin.

There are several diseases that are miserable and worthy of gene therapy approaches, said associate professor of dermatology Dr. Jean Tang, who co-led the trial with Dr. Peter Marinkovich. But epidermolysis bullosa, she said, is one of the worst of the worst.

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It took nearly 20 years for Stanford researchers to bring this gene therapy to Roeder and her fellow patients.

It is very satisfying to be able to finally give patients something that can help them, said Marinkovich.In some cases, wounds that had not healed for five years were successfully healed with the gene therapy.

Before, he noted, there was only limited amounts of what you can do for them. We can treat their wounds and give them sophisticated Band-Aids. But after you give them all that stuff, you still see the skin falling apart, Marinkovich said. This makes you feel like youre making a difference in the world.

Roeder seemed healthy at birth. But when her family celebrated her arrival by imprinting her tiny feet on a keepsake birth certificate, she blistered. They encouraged her to lead a normal childhood, riding bicycles and gentle horses. Shes happily married. But shes grown cautious, focusing on photography, writing a blog and enjoying her pets.

Scarring has caused her hands and feet digits to become mittened or webbed. Due to pain and risk of injury, she uses a wheelchair rather than walking long distances.

Every movement has to be planned out in my head so I dont upset my skin somehow, she said. Wound care can take three to six hours a day.

She heard about the Stanford research shortly after losing her best friend, who also had epidermolysis bullosa, to skin cancer, a common consequence of the disease. Roeder thought: Why dont you try? She didnt get the chance.

The team of Stanford experts harvested a small sample of skin cells, about the size of a pencil eraser, from her back. They put her cells in warm broth in a petri dish, where they thrived.

To this broth they added a special virus, carrying the missing gene. Once infected, the cells began producing normal collagen.

They coaxed these genetically corrected cells to form sheets of skin. The sheets were then surgically grafted onto a patients chronic or new wounds in six locations. The team reported their initial results in Novembers Journal of the American Medical Association.

Historically, medical treatment has had limited options: excising a sick organ or giving medicine, said Dr. Anthony E. Oro of Stanfords Institute for Stem Cell Biology and Regenerative Medicine. When those two arent possible, theres only symptom relief.

But the deciphering of the human genome, and new tools in gene repair, have changed the therapeutic landscape.

Now that we know the genetic basis of disease, we can use the confluence of stem cell biology, genome editing and tissue engineering to develop therapies, Oro said.

Its not practical to wrap the entire body of a patient with epidermolysis bullosa in vast sheets of new skin, like a mummy, Oro said.

But now that the team has proved that gene therapy works, they can try related approaches, such as using gene-editing tools directly on the patients skin, or applying corrected cells like a spray-on tan.

A cure doesnt take one step, said Tang. It takes many steps towards disease modification, and this is the first big one. Were always looking for something better.

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Stanford team is growing healthy skin for ill patients - The Mercury News

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Stem cell registry drive at SAU Feb. 14-15 – SAU

Posted: February 11, 2017 at 5:46 pm

When three Southern Arkansas University nursing students started organizing next weeks stem cell registry drive more than three months ago, they were not aware that a member of the Mulerider family is one of more than 1,400 whose life could be saved.

The stem cell/bone marrow registry drive is scheduled for 9 a.m.-3:30 p.m. on February 14-15 both in the Reynolds Center Rotunda and the SAU Baptist Collegiate Ministry. For more information, contact Dr. Becky Parnell at (870)235-4365 or at bbparnell@saumag.edu.

The SAU BSN students initially behind the project are Renee Langley, Tabitha Elliott and Courtney Owens. Parnell explained that while attending the Arkansas Student Nurses Association annual meeting in Little Rock, the students were introduced to the need for bone marrow donors. They even registered to be possible donors themselves. She said they realized this project was a perfect example of how nurses can impact the care of people outside the normal hospitalized patient.

They recognized how many people this could potentially impact and wanted to recruit more people (to register), said Parnell. I have seen the bone marrow process it is truly a life-saving intervention for many people that are devastated by leukemia.

When Parnell began promoting the registry event on campus, it was brought to her attention that the daughter of Magnolia native, 1984 SAU alum and Board of Governors Chair Beth Galway, Sydney, is suffering with acute myeloid leukemia and in dire need of a bone marrow transplant.

When Sydney was diagnosed with acute myeloid leukemia, the doctors told us that Sydneys only cure would come from a bone marrow transplant. The doctors were, and are, confident of the success of her treatment due to the fact that she has a high chance to find a perfect bone marrow donor, said Galway.

Her increased chance of finding a match, Galway explained, is simply because she is a Caucasian female which has one of the highest bone marrow donor rates. She has a 97% chance to find a donor.

Of course, the first donor they looked at was her sister. A sibling has only a 25% chance to be a match; a parent even less. Sydneys sister was not a match, said Galway.

Donor matches are generally based on race. With todays diverse community, the need for bone marrow donors from minority and mixed race groups is high. An African American patient has only a 66% chance to find a match.

The doctors and nurses that I have talked to indicate that the need is huge for African Americans as well as donors from India, said Galway.

She said that the treatment for Sydney, who is a sophomore in college, is now in phase 3. Her next step is a bone marrow transplant.

We hope to have a perfect match for her and pray that the donor will be willing to do all that is necessary for providing the blood or bone marrow needed for the transplant, said Galway.

The drive is being sponsored by SAUs Department of Nursing and University Health Services. Junior and senior BSN students will also be assisting in the bone marrow drive as a professional development activity.

Becoming a member of a stem cell/bone marrow registry only requires that you provide a swab of the cells inside your cheek. To register is a painless and fast way to possibly save a life.

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Stem cell registry drive at SAU Feb. 14-15 - SAU

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