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GK-12 : STEM Activities and Resources for K-12 Teachers …

Posted: November 29, 2016 at 8:41 am

For All Grades (K-12) From AAAS

BEN (BiosciEdNet) Digital Library Portal for Teaching and Learning in the Biological Sciences Teaching and learning resources for undergraduate and graduate students from collaborating organizations in the biological sciences

Science NetLinks Standards-based lesson plans for teachers that incorporate reviewed Internet resources and that are searchable by Project 2061 Benchmarks

Science Update A daily, 60-second feature radio show covering the latest discoveries in science, technology and medicine since 1988. Science Update answers listeners science questions, phoned in to our toll-free answer line, 1-800-WHY-ISIT (949-4748), or submitted to our online form. A weeks worth of Science Update news briefs is available for download as the Science Update Podcast

The Secret Lives of Wild Animals Fascinating website for children (and the kid in all of us) that features special creature camsvideos from the animals viewpoint. Modern technologies like global tracking systems and ultraminiaturized sensors now provide researchers with intimate glimpses of rarely seen behaviors of wild animals

Practical Uses of Math and Science (PUMAS) A collection of one-page examples of how math and science topics taught in K-12 classes can be used in interesting settings. The examples are written primarily by scientists and engineers.

Treasures in the Sea A new resource book, available online, provides teachers of students in grades 3-6 with scientific information and engaging, hands-on activities related to marine conservation. These resources will help students understand life cycles, critical habitats, cultural and economic connections and the urgency of marine wildlife conservation and management. Produced by the American Museum of Natural History Center for Biodiversity and Conservation; the Bahamas National Trust; and the Bahamas Ministry of Education, Youth, Sports and Culture. Funded in part by NSF.

Idaho State UniversityPhysical and life sciences, and robotics activities for grades 5-12

Kent State Geoscience activities and lesson plans developed by Fellows, and links to and reviews of activities from the Digital Library for Earth System Education (DLESE)

Michigan State UniversityLessons in general science, biology, ecology, earth science, chemistry, and physics. Arranged by grade level.

North Carolina State University Hands-on lessons with engineering applications

Penn State University Multi-day standards-aligned instructional modules using the theme of advanced transportation technologies. Topics, for grades 6-12, include air bags, fuel cells, hybrid electric vehicles, and memory metals

University of Colorado Lessons and activities on the TeachEngineering.org Digital Library Collection that use engineering as a vehicle for hands-on integration of science and math learning. Engineering GK-12 programs are encouraged to utilize this mechanism to publish and disseminate curriculum

University of Montana Ecological inquiries for K-12 and natural history guide for teachers and students

Ohio State University Science investigations for grades 3-5

St. Josephs University Natural science units for grades K-5

University of Alaska Activities focused on earth, life, and physical sciences developed by GK12 fellows

University of South Carolina Inquiry-based engineering, science and math activities for elementary and middle school classroom

University of South Florida Lessons, experiments, and modules (genetic engineering, biosensors, robotics, nanotechnology) based on Sunshine State Standards for grades 3-5

Colorado School of Mines Hands-on middle school mathematics and science activities with connections to engineering

Cornell University Resources for science projects developed by graduate and undergraduate students in collaboration with middle and high school teachers

Emory Problem-based lessons for middle and high school science and math

Illinois State University Biology, chemistry, and math lessons

Texas A&M Curriculum materials that support students in grades 6-12 in their use of spatial thinking, GIS, and remote sensing

University of Alaska Activities focused on earth, life, and physical sciences developed by GK12 fellows

University of Arkansas Math and science lessons for middle school students (primarily grades 6 & 7)

University of Central Florida Inquiry-based and geared for upper middle and lower high school students

University of Illinois Urbana-Champaign Inquiries involving water; and geology units featuring visualization of earthquakes and plate tectonics

California State University Northridge Mathematics activities for middle school and high school studetns

Cornell University Resources for science projects developed by graduate and undergraduate students in collaboration with middle and high school teachers

Emory Problem-based lessons for middle and high school science and math

Illinois State University Biology, chemistry, and math lessons

Texas A&M Curriculum materials that support students in grades 6-12 in their use of spatial thinking, GIS, and remote sensing

University of Central Florida Inquiry-based and geared for upper middle and lower high school students

University of Illinois Urbana-Champaign Chemistry units featuring visualization and models; American history units; and geology units featuring visualization of earthquakes and plate tectonics

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GK-12 : STEM Activities and Resources for K-12 Teachers ...

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World Stem Cell Summit

Posted: November 29, 2016 at 8:41 am

Cellular Dynamics

Cellular Dynamics International (CDI), a FUJIFILM company, is a leading developer and manufacturer of human cells used in drug discovery, toxicity testing, stem cell banking, and cell therapy development. The Company partners with innovators from around the world to combine biologically relevant human cells with the newest technologies to drive advancements in medicine and healthier living. CDIs technology offers the potential to create induced pluripotent stem cells (iPSCs) from anyone, starting with a standard blood draw, and followed by the powerful capability to develop into virtually any cell type in the human body. Our proprietary manufacturing system produces billions of cells daily, resulting in inventoried iCell products and donor-specific MyCell Products in the quantity, quality, purity, and reproducibility required for drug and cell therapy development. Founded in 2004 by Dr. James Thomson, a pioneer in human pluripotent stem cell research, Cellular Dynamics is based in Madison, Wisconsin, with a second facility in Novato, California. For more information, please visit http://www.cellulardynamics.com, and follow us on Twitter @CellDynamics. FUJIFILM Holdings Corporation, Tokyo, Japan brings continuous innovation and leading-edge products to a broad spectrum of industries, including: healthcare, with medical systems, pharmaceuticals and cosmetics; graphic systems; highly functional materials, such as flat panel display materials; optical devices, such as broadcast and cinema lenses; digital imaging; and document products. These are based on a vast portfolio of chemical, mechanical, optical, electronic, software and production technologies. In the year ended March 31, 2015, the company had global revenues of $20.8 billion, at an exchange rate of 120 yen to the dollar. Fujifilm is committed to environmental stewardship and good corporate citizenship. For more information, please visit: http://www.fujifilmholdings.com.

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World Stem Cell Summit

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7th International Conference on Stem Cells and Cancer …

Posted: November 27, 2016 at 8:45 pm

Dear Colleagues and Students,

We cordially invite you to attend the 7th International Conference on Stem Cells and Cancer (ICSCC-2016): Proliferation, Differentiation and Apoptosis, Goa, India from 21-23 October 2016.

Registration and abstract submission is open now, please click on the Registration or Abstracts menu above to know more.

Conference Starts at: 9:00am, 21 Oct 2016 Conference Ends at: 6:30pm, 23 Oct 2016

Venue: Ravindra Bhavan, Margao, Goa, (www.ravindrabhavanmadgao.org)India.

You can also register and attend the conference without submitting an abstracts.

We look forward to welcoming you to the 7th ICSCC-2016 in Goa, India.

Organizer: Dr. Sheo Mohan Singh MSc(UK), PhD(Germany), PDF(USA,UK) Director, International Center for Stem Cells, Cancer and Biotechnology (ICSCCB), Pune, India (http://www.icsccb.org/)

Co-organizers: Dr. Keith Humphries Director, Terry Fox Laboratory,BC Cancer Agency, Vancouver, Canada

Dr. Christian Buske Director, Institute of Experimental Cancer Research,Comprehensive Cancer Center, University Hospital Ulm,Ulm, Germany

Dr. Laxman Gangwani Associate Professor, Department of Biomedical Sciences,Texas Tech University Health Sciences Center,El Paso, USA

Dr. Rajani Kanth Vangala Director of Research, Thrombosis Research Institute,Bangalore,India

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7th International Conference on Stem Cells and Cancer ...

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Non-Surgical – The New Jersey Orthopaedic Institute

Posted: November 27, 2016 at 8:44 pm

From strains to sprains and more, the vast majority of sports related injuries respond well with non-surgical care.

That is why it is always the first approach at NJOI. The NJOI orthopaedists, and in particular its primary care physicians specializing in sports medicine, offer a variety of non-surgical services for musculoskeletal care. NJOIs vast experience with athletes of all ages and levels emphasizes both injury care and prevention with these services.

Nonsteroidal anti-inflammatory drugs (NSAIDs) include aspirin, ibuprofen (e.g., Advil), naproxen (e.g., Aleve) and nabumetone (e.g., Relafen). These medications address an injury by helping reduce pain and inflammation. However, they can have negative effects if used improperly and it is important than the experts at NJOI assess and recommend these medications for each individual so that they can be taken safely and effectively.

NJOI also offers various injections, including cortisone. These injections are designed to help with chronic, painful inflammation. Delivering cortisone by injection provides very high concentrations of the medication directly to the affected area, while minimizing potential side effects. These injections usually work within a few days, and the effects can last up to several weeks and sometimes even permanently.

Its extensive sports medicine experience means NJOI can provide all of its patients with the best advice for an athletic or active lifestyle. This includes such important areas as strength training and conditioning, flexibility exercises, sports nutrition, and concussion management.

While taping and bracing should not be used in place of personalized medical care when indicated (such as for ongoing pain or serious injury), nor as a substitute for important rehabilitation exercises, these methods can provide extra support for joint instability or for rehabilitating injuries. Both taping and bracing are a common feature of all sports participation. The experts at NJOI understand the concepts and techniques of these methods, and are particularly experienced due to their numerous positions as youth, collegiate and professional sports team physicians.

Platelet-rich plasma (PRP) has become a treatment option for a wide variety of athletes, from recreational to avid amateurs to professionals. This procedure is particularly useful for persistent partial tendon problems, such as tennis elbow, plantar fasciitis, quadriceps and patellar tendon tears; partial muscle tears and ligament tears as well as utilized in conjunction with surgical procedures to increase the chances of healing. While its success rate may vary, PRP holds out hope as a non-invasive potential solution to healing.

In addition to its plasma component, blood also contains red and white cells, as well as platelets. Besides their role in clotting blood, platelets also contain healing properties due to their growth factors (which are the proteins in the blood). For PRP, blood is drawn from the patients. The platelets are separated in a centrifuge process, increasing their concentration from 5 to 10 times greater than normal. They are then combined with the remaining blood and injected into injured tissues in order to facilitate more rapid healing. PRP is a non-surgical treatment, and the risks of PRP are minimal.

Among the ranks of those who have been treated with PRP are professional athletes, like Tiger Woods, Kobe Bryant and Rafael Nadal, as well as two injured NFL players before winning a Super Bowl. Countless weekend warriors have also found relief through this treatment.

While much publicity surrounds use of PRP for athletes, the procedure actually began in the 1990s in connection with plastic surgery. At NJOI, we use PRP for a variety of conditions. A number of studies have demonstrated that PRP injections have lessened pain and improved function in joints, including the elbow, wrist, shoulder, hip, knee, and ankle.

In separate trials done in 2011, PRP lowered blood loss in 81 patients with knee replacements, and lessened pain for 21 with tennis elbow.* *http://www.bloomberg.com/news/2012-08-24/blood-therapy-used-by-tiger-woods-lures-everyday-athletes.html

Over a million U.S. patients have been treated with stem cells in the past decade and a half. Currently, there are over 70 proven therapies using adult stem cells. Stem cell therapy at NJOI, done via ultrasound guidance, has the potential to help accelerate healing in tendon/ligament injuries, and to augment the sub-optimal healing from other techniques or surgeries.

The process of receiving stem cell therapy starts with harvesting your own stem cells from the bone marrow. Stem cells are harvested from the iliac crest (hip bone) using AN anesthetic and a special small biopsy needle. These stem cells- called Mesenchymal Stem Cells (MSC)- areautologous, meaning they are the patients own stem cells.

Harvesting MSCs for injection therapy is done in our office and only takes a short amount of time.The skin and hip bone are numbed. A special needle is then passed through the cortex of the bone into the marrow cavity. This is apainlessprocedure in most cases.The liquid marrow is then very slowly drawn into a syringe.

Then your bone marrow gets spun in a centrifuge for 15 minutes allowing the undifferentiated mesenchymal stem cells to separate from the platelets and blood. Our experienced surgeon will then inject your own stem cells into the joint or damaged tissue.

These mesenchymal stem cells have the ability to turn into cartilage, ligament, tendon, bone, nerve tissue, blood vessels, or muscle tissue. These cells find the area of damage, connect to your DNA and determine the code that tells them into what to reproduce. Stem cells can only grow the same tissue you would have had before the damage.

This procedure is particularly useful for persistent partial tendon tears, such as tennis elbow, plantar fasciitis, quadriceps and patellar tendon tears; partial muscle tears; meniscus tears in the knee and chondromalacia patella (patellofemoral syndrome).

Arthritis afflicts about 50 million people of all ages throughout the country. Osteoarthritis is the most common form of this disease, characterized by deteriorated cartilage surrounding the joints. Healthy cartilage serves to cushion and protect the bones in joints preventing friction and allowing for fluid movement.

Viscosupplementation is a minimally invasive, therapeutic treatment for those who have not seen improvements through medication or other traditional treatments. Hyaluronic acid, a naturally occurring gel-like substance found in the synovial fluid of the joints, is injected into the affected joint and acts as a lubricant. Individuals with osteoarthritis typically have less of this naturally occurring acid, so the treatment works to supplement for the lack of fluid. Viscosupplementation at NJOI is primarily used on the knee, but can also be done on the hip or shoulder.

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Non-Surgical - The New Jersey Orthopaedic Institute

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Juice Beauty STEM CELLULAR Anti-Wrinkle Solutions Kit

Posted: November 27, 2016 at 8:44 pm

Stem Cellular Anti-Wrinkle Moisturizer: Juice Beauty proprietary blend of fruit stem cells, apple buds, grape buds & lemon bark. Organic juices of Pyrus Malus (Organic Apple Juice)*, Vitis Vinifera (Organic White Grape Juice)*, Citrus Medica Limonum (Organic Lemon Juice)*, Aloe Barbadensis (Organic Aloe Juice)*, Caprylic/Capric Triglyceride, Simmondsia Chinensis (Organic Jojoba Seed Oil)*, Cetearyl Alcohol, Vegetable Glycerin, Glyceryl Stearate, Stearic Acid, Helianthus Annuus (Organic Sunflower Seed Oil)*, Ethylhexyl Palmitate, Xanthan Gum, Butyrospermum Parkii (Organic Shea Butter)*, Malus Sylvestris (Apple Buds), Vitis Vinifera (Grape Buds) & Citrus Limonum (Lemon Bark), Tocopherol (Vitamin E), Organic Essential Fatty Acids Of Oenothera Biennis (Organic Evening Primrose)*, Linum Usitatissimum (Organic Linseed Oil)*, Borago Officinalis (Organic Borage Seed Oil)*, Sodium Benzoate, Potassium Sorbate, Ethylhexylglycerin, Magnesium Ascorbyl Phosphate (Vitamin C), Panthenol (Vitamin B5), Allantoin, Citrus Reticulata (Mandarin), Litsea Cubeba (May Chang) And Cinnamomum Camphora (Ho Wood) Pure Essential Oils.

Stem Cellular Anti-Wrinkle Booster Serum: Juice Beauty proprietary blend of fruit stem cells, apple buds, grape buds & lemon bark. Organic juices of Pyrus Malus (Organic Apple Juice)*, Vitis Vinifera (Organic White Grape Juice)*, Citrus Medica Limonum (Organic Lemon Juice)*, Aloe Barbadensis (Organic Aloe Juice)*, Vegetable Glycerin, Xanthan Gum, Glyceryl Stearate, Butyrospermum Parkii (Organic Shea Butter)*, Ethylhexyl Palmitate, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Helianthus Annus (Organic Sunflower Seed Oil)*, Malus Sylvestris (Apple Buds), Vitis Vinifera (Grape Buds) & Citrus Limonum (Lemon Bark), Organic Plant Oils Of Simmondsia Chinensis (Organic Jojoba Seed)*, Oenothera Biennis (Organic Evening Primrose Oil)*, Linum Usitatissimum (Organic Linseed Oil)*, Borago Officinalis (Organic Borage Seed Oil)*, Sodium Benzoate, Potassium Sorbate, Ethylhexylglycerin, Tocopherol (Vitamin E), Magnesium Ascorbyl Phosphate (Vitamin C), Panthenol (Vitamin B5), Stearic Acid, Allantoin, Sodium Hyaluronate (Vegetable Hyaluronic Acid), Citrus Reticulata (Mandarin), Litsea Cubeba (May Chang) And Cinnamomum Camphora (Ho Wood) Pure Essential Oils.

Stem Cellular Lifting Neck Cream: Juice Beauty proprietary blend of fruit stem cells, apple buds & grape buds. Organic juices of Pyrus Malus (Organic Apple Juice)*, Vitis Vinifera (Organic Grape Juice)*, Aloe Barbadensis (Organic Aloe Juice)*, Vegetable Glycerin, Ethylhexyl Palmitate (Plant Derived), Helianthus Annus (Organic Sunflower Seed Oil)*, Glyceryl Stearate (Plant Derived), Diheptyl Succinate (Plant Derived), Sucrose Stearate (Plant Derived), Stearyl Alcohol, Sucrose Polystearate (Plant Derived), Cetearyl Olivate (Plant Derived), Sorbitan Olivate (Plant Derived), Caprylyl Glycol, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Malus Sylvestris (Apple Buds), Vitis Vinifera (Grape Buds), Borago Officinalis (Organic Borage Seed Oil)*, Linum Usitatissimum (Organic Linseed Oil)*, Rosa Canina (Organic Rosehip Fruit Oil)*, Camellia Sinensis (Organic White Tea Leaf Extract)*, Chamomilla Recutita (Organic Chamomile Extract)*, Lavandula Angustifolia (Organic Lavender Extract)*, Arnica Montana (Organic Arnica Flower Extract)*, Vitis Vinifera (Grapeseed Oil), Lonicera Caprifolium (Honeysuckle Extract), Algae Extract, Squalane (Plant Derived), Magnesium Ascorbyl Phosphate (Vitamin C), Panthenol (Vitamin B5), Tocopherol (Vitamin E), Carya Ovata (Hickory Extract), Stearic Acid (Plant Derived), Ethylhexylglycerin (Plant Derived), Pullulan, Allantoin, Xanthan Gum, Sodium Phytate (Plant Derived), Menthyl Lactate, Capryloyl Glycerin/Sebacic Acid Copolymer, Isomalt (Plant Derived), Sodium Hydroxide, Litsea Cubeba (May Chang) And Cinnamomum Camphora (Ho Wood) Essential Oils.

Stem Cellular Eye Treatment: Juice Beauty proprietary blend of fruit stem cells, apple buds, grape buds & lemon bark. Organic juices of Pyrus Malus (Organic Apple Juice)*, Vitis Vinifera (Organic White Grape Juice)*, Citrus Medica Limonum (Organic Lemon Juice)*, Aloe Barbadensis (Organic Aloe Juice)*, Vegetable Glycerin, Xanthan Gum, Glyceryl Stearate, Ethyhexyl Palmitate, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Organic Plant Oils Of Helianthus Annuus (Organic Sunflower Seed Oil)*, Simmondsia Chinensis (Organic Jojoba Seed Oil)*, Oenothera Biennis (Organic Evening Primrose Oil)*, Linum Usitatissimum (Organic Linseed Oil)*, Borago Officinalis (Organic Borage Seed Oil)*, Malus Sylvestris (Apple Buds), Vitis Vinifera (Grape Buds) & Citrus Limonum (Lemon Bark), Sodium Benzoate, Potassium Sorbate, Ethylhexylglycerin, Tocopherol (Vitamin E), Magnesium Ascorbyl Phosphate (Vitamin C), Stearic Acid, Butyrospermum Parkii (Organic Shea Butter)*, Panthenol (Vitamin B5), Allantoin, Sodium Hyaluronate (Vegetable Hyaluronic Acid)

*certified organic ingredient

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Juice Beauty STEM CELLULAR Anti-Wrinkle Solutions Kit

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small carpenter bees, Ceratina spp. – UF/IFAS

Posted: November 27, 2016 at 8:43 pm

common name: small carpenter bees scientific name: Ceratina spp. (Insecta: Hymenoptera: Apidae: Xylocopinae) Introduction - Synonymy and Taxanomy - Distribution - Identification - Biology - Economic Importance - Selected References Introduction (Back to Top)

In America, north of Mexico, the small carpenter bees, Ceratina, comprise one of two genera of the subfamily Xylocopinae. The other genus contains the large carpenter bees, Xylocopa. Of the 21 species of Ceratina in America north of Mexico, only two are known to occur in Florida: Ceratina cockerelli H.S. Smith, and Ceratina dupla Say.

Figure 1. Differences in wing venation between the small carpenter bees, Ceratina spp., and the large carpenter bees, Xylocopa spp. Drawings by Division of Plant Industry.

Mitchell (1962) described the subspecies Ceratina dupla floridanus from Florida, but Daly (1973) synonymized it simply as a more densely punctate, and brighter blue population of the typical eastern Ceratina dupla.

At various times, carpenter bees have been placed in the families Anthophoridae, Xylocopidae or Apidae. Hurd and Moure (1963) traced the taxonomic history of these bees, with the most recent placement within Apidae (Krombein 1967). This family is characterized, in part, by the jugal lobe of the hindwing being absent or shorter than the submedian cell and by the forewing having three submarginal cells.

Ceratina cockerelli is found throughout Florida and most of the southern coastal states from Texas to Georgia (Daly 1973). Specimens have not been reported from Alabama or Mississippi, but probably occur there. Ceratina dupla is found throughout Florida as well as most of the eastern United States (Daly 1973).

Within the family Apidae, carpenter bees are distinguished most easily by the triangular second submarginal cell, and by the lower margin of the eye almost in contact with the base of the mandible (i.e., the malar space is absent).

The easiest method of separating Ceratina from Xylocopa is by size: Ceratina are less than 8 mm in length whereas Xylocopa are 20 mm or larger. In addition, in Ceratina the second submarginal cell is about as high as it is wide basally, whereas in Xylocopa it is about half as high as it is wide basally.

Small carpenter bees are black, bluish green, or blue, and often have yellowish or whitish markings on the clypeus, pronotal lobes, and legs. The two Florida species of Ceratina may be separated as follows:

Figure 2. Small carpenter bee, Ceratina dupla Say, dorsal and side views. Photograph by Division of Plant Industry.

In general, members of this genus use their mandibles to excavate nests in the pith of broken or burned plant twigs and stems. Females overwinter as adults in partially or completely excavated stems. In the spring, this resting place (hibernaculum) is modified into a brood nest by further excavation. Rau (1928) reported several nests of Ceratina calcarata Robertson that ranged from 20 to 30 cm deep. Daly (1966) measured 126 nests of Ceratina dallatorreana Friese that ranged from 3 to 19 cm deep. When a desired depth is reached, the female collects pollen and nectar, places this mixture at the base of the burrow, lays an egg on the provision, and then caps off the cell with masticated plant material. Several cells are constructed end to end in each plant stem, the absolute number depending upon the depth to which the nest was excavated. Daly (1966) found a range of two to 12 cells (19 completed nests examined) for Ceratina dallatorreana.

Figure 3. Nest diagrams of the small carpenter bees, Ceratina spp. Left: overwintering nest (hibernaculum); Right: active brood nest with (A) bee larva and (B) provisions. Drawing by Division of Plant Industry.

The female works at a single stem until it is filled with cells, each of which contains provisions and an egg or larva, except for the last cell near the nest entrance. Here the bee rests and, according to Malyshev (1936) and Daly (1966), defends her nest from intruders. The female bee remains with the nest until her progeny emerge. Since the nest has been under construction for some time, the oldest progeny (at the base of the nest) mature and begin to gnaw their way out before the others above them are ready. This poses a special problem because the bees do not emerge laterally through the side of the stem, but vertically through all the other cells. Rau described this process thoroughly for Ceratina calcarata (1928).

Essentially the oldest bee chewed apart the cell cap above and packed it at the base of its own cell. If the bee above was not mature it was carefully moved down to rest on the new "floor." If the bee above was mature, the eldest passed it by and worked on the cell cap above, passing the pithy material to the younger bee or bees beneath. These bees packed the material at the base of the nest, moving and adjusting any remaining pupae. Thus the mature bees at the base of the nest gained freedom by "... a process of displacement, gradually shifting the material behind them as they make their way to the top" (Rau 1928). In the process observed by Rau, the eldest bees took eight days to make their way to the entrance; several days later, all the bees emerged.

Special biological references to the Ceratina occurring in Florida are scarce. Extensive flower visitation records were given by Mitchell (1962) and Daly (1973). The only biological record forCeratina cockerelli was given by Daly (1973) who cited Sage (in litt.) as reporting nests "... in dead, cut stems of sea-oats, Uniola paniculata L., on the beach of Mustang Island, Texas." The more important papers, though wholly inadequate, are Ashmead (1894), Comstock and Comstock (1895), and Graenicher (1905).

Unlike their larger relatives in the genus Xylocopa, the small carpenter bees in the genus Ceratina are not known to be of economic importance.

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small carpenter bees, Ceratina spp. - UF/IFAS

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Stemonix, a stem cell research firm, wins Minnesota Cup …

Posted: November 27, 2016 at 8:43 pm

Ping Yeh, the leader of the disease-testing company that just won the Minnesota Cup, is a mechanical engineer who decided to shift to health products from electronics after a bout with cancer.

We are just thankful to be part of this entrepreneurial community, Yeh said Friday, a day after his firm, Stemonix, took the grand prize in the states biggest business competition.

The company is improving production, growth and manufacture of human heart and brain cells for drug toxicity and efficacy testing. It already is selling the results to several unspecified pharmaceutical companies, Yeh said.

The graduate of the University of California, San Diego said he started Stemonix in 2014, after recovering from Hodgkins lymphoma that was diagnosed in 2012. After receiving a maximum-toxicity treatment that cured his cancer, Yeh learned the only way to test for heart damage as a result of the treatment was after, not before the treatment. That prompted him to use his knowledge of nanotechnology to start Stemonix.

We sell human minibrains and human heart tissue, samples and human stem cells that are derived from skin or blood or teeth, he said. I want to help cure the toughest diseases of our society. Our technology, in addition to being helpful to drug companies, eventually will help physicians understand the disease and optimal treatments.

Yeh, who earned an MBA from the University of Minnesota, leads a team of 18 employees and consultants at downtown Minneapolis-based Stemonix. He said the company previously has raised about $5 million in equity, mostly from individual angel investors in Minnesota, North Dakota and San Diego. He declined to name drug-company customers or discuss financial projections of fledgling Stemonix.

In August, Stemonix and seven other division winners won $30,000 apiece in seed capital, as the monthslong Minnesota Cup competition progressed to Thursday nights presentation by the eight finalists.

Over the past 12 years more than 11,000 aspiring entrepreneurs have participated in this competition, and gone on to raise more than $225 million to foster innovation and job creation in Minnesota, said Melissa Kjolsing, executive director of Minnesota Cup. The finalists were:

Activated Research Co., in energy/clean tech/water category;

SelfEco Garden in food/ag/beverage;

Berd Spokes in general

Vugo in high-tech;

Stemonix in life science/health IT;

Asiya in social entrepreneurship;

Minnealloy Magnetics in student;

ExpressionMed in youth.

In addition to the grand prize, the Carlson Family Foundation awarded $25,000 to Asiya, the top female-led business.

Meda, the economic-development counselor that nurtures minority-owned businesses, also gave $10,000 to Asiya, as the minority entrepreneur with the most innovative business concept.

A record 1,500 entrepreneurs participated in the Minnesota Cup competition, which this year introduced a youth division for budding entrepreneurs 18 and younger.

A record 38 percent of entries were from female-led teams. More information: mncup.org.

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Pan Pacific Surgical Hawaii Plastic Surgery Symposium

Posted: November 27, 2016 at 8:42 pm

Why go to Hawaii? is not a question often asked since you may already have the answer. No one would question that Hawaii is one the most beautiful destinations on earth if not the earthly paradise. We can spend hours praising the spiritual beauty of its dance (hula) and its unique music heard over the emerald valleys and golden sands as well as the visceral power of its active volcanos with a constantly flowing river of molten red lava. Our next biennial and 33rd Hawaii Plastic Surgery Symposium is conveniently planned on Saturday and Sunday of February 17 and 18, 2018 (not 2017) to coincide with the ugly weather that prevails in most parts of the northern hemisphere where the cold, the ice and blizzard paralyze outdoor activities. So put on your imaginary lei and perhaps mix yourself a real Mai Tai and plan attending our next symposium in February 2018.

We present another great program with world-renowned speakers in 2018. We will be fortunate to have among the guest Faculty, Melvin Spira, Professor Emeritus and former Chairman of Plastic Surgery at Baylor-Houston; Mark Granick, Professor and Chair at Rutgers-NJ; Ernie Manders, Professor University of Pittsburg Med School; Dan Del Vecchio of Harvard/MGH; Angela Pratt, Professor and Chief of Ob/Gyn at University of Hawaii-Honolulu; Professor Wong C Choi of Seoul, South Korea; Frank Lista (Toronto-Canada); Maurice Nahabedian, Professor and Chairman, Georgetown University; Reza Jarrahy of UCLA; Ash Ghavami (Beverly Hills); Charles Lee, Clin. Prof. Seoul- S.Korea, and a host of other well-recognized authorities. The topics will include: what I did right and wrong as a plastic surgeon; Understanding metaphysics of Beauty; Fat Grafting; Stem Cells and their Future; Breast Implants; Rhinoplasty; Cosmetic Surgery of Genitalia; Face, Eye and Future of Transplantation; Breast Reconstruction; Gynecomastia; Patient Selection and a 2 hours course on Hormone Treatment. CME Category I pending up to 17 hours.

Registration fees: $550 for Surgeons ($500 for registrations before September 1, 2017); $200 for Allied Health; $200 for spouses; No registration fee for residents and medical students. The Registration fee includes all meals and a dinner reception on Saturday evening on February 17, 2018.

Best wishes and see you in February 2018!

Tom Kosasa, F. Don Parsa, Paul Faringer, Robert Peterson, Ash Ghavami, Tom Crabtree

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Pan Pacific Surgical Hawaii Plastic Surgery Symposium

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Stormy Chamberlain – Faculty Directory UConn Health

Posted: November 27, 2016 at 8:41 pm

Using induced pluripotent stem cells to model Angelman syndrome Lecture Wentworth Institute of Technology 2015 Boston, MA Using induced pluripotent stem cells to study Angelman syndrome. Lecture Angelman Syndrome Foundation 2015 Induced pluripotent stem cell models of Dup15q Talk Dup15q Alliance 2015 Orlando, FL Induced pluripotent stem cell models to study Dup15q Talk Dup15q Alliance 2015 Orlando, FL Induced pluripotent stem cell (iPSC) models of Angelman syndrome Plenary Lecture Fighting Angels Foundation 2015 Bridgeport, CT Genetics 101 Lecture Angelman Syndrome Foundation 2015 Schaumberg, IL You can do it: starting an academic career and family Talk Graduate Women in Science and Medicine 2015 Farmington, CT Induced pluripotent stem cell models to study Angelman syndrome Talk ORSA (Organizzazione di sindrome d'Angelman) 2015 Trevi, Italy Using induced pluripotent stem cells to study 15q imprinting disorders Plenary Lecture Societa Italia di Genetica Umana (SIGU) 2015 Remini, Italy Induced pluripotent stem cell models of Angelman and Dup15q syndromes Talk Simons Foundation for the Social Brain 2014 Cambridge, MA Using induced pluripotent stem cells to model Angelman syndrome Talk Angelman Syndrome International Meeting 2014 Paris, France Making sense of an antisense transcript Talk Illumina Connecticut User Group meeting 2014 New Haven, CT Induced pluripotent stem cell models of Angelman and Dup15q syndromes Talk Angelman Syndrome Foundation and Dup15q Alliance Joint Scientific Symposium 2014 Cambridge, MA Induced pluripotent stem cell models of Autism Spectrum Disorders Talk Pediatric Translational Research Seminar Series 2014 Farmington, CT Induced pluripotent stem cell (iPSC) models of Angelman Syndrome Talk Canadian Angelman Syndrome Society Biannual Meeting 2014 Ottawa, Ontario, Canada Induced pluripotent stem cells and disease modeling Lecture Albertus Magnus College 2014 North Haven, CT iPSCs to study Angelman Syndrome and 15q Duplication associated autism Talk John D. Wiley Seminar Series, Waisman Center, U of Wisconsin-Madison 2013 Madison, Wisconsin Human induced pluripotent stem cell models of chromosome 15q imprinting disorders Talk University of Florida Genetics Institute Seminar Series 2013 Gainesville, FL Induced Pluripotent Stem Cell Models to Study Dup15q Talk Dup15q Family Meeting 2013 Bloomington, MN Induced Pluripotent Stem Cell Models of Dup15q syndrome Talk Dup15q Scientific Meeting 2013 Sacramento, CA Neuronal Synaptic and Circuit Dysfunction in the Autism Spectrum Disorders Talk ARC Symposium 2013 Storrs, CT iPSC models of 15q duplication syndrome Talk UCHC Human Genetics Seminar Series 2013 Farmington, CT Lessons Learned from Induced pluripotent Stem Cell Models of Angelman Syndrome Talk ORSA Angelman Syndrome International Scientific Symposium 2013 Rome, Italy Lessons Learned from Human Induced Pluripotent Stem Cell Models of Angelman Syndrome Talk ORSA Angelman Syndrome International Family Meeting 2013 Trevi, Italy Induced Pluripotent Stem Cell Models of Angelman and Dup15q Syndromes Talk UCHC Dept of Neuroscience Seminar Series 2013 Farmington, CT Human iPSCs to model chromosome 15q11-q13 imprinting disorders Talk Tri-Institutional Stem Cell retreat 2012 Wesleyan University, Middletown, CT iPSC models of Angelman syndrome and autism Talk Human Genetics Seminar Series 2012 Farmington, CT iPSC models of Angelman syndrome and autism Talk UMass Amherst Dept. of Veterinary and Animal Sciences 2012 Amherst, MA iPSC models of chromosome 15q imprinting disorders Talk University of North Carolina Neuroscience Center 2012 Chapel Hill, NC Induced pluripotent stem cell models of Angelman syndrome Talk Angelman Syndrome Foundation/Donor's dinner 2012 Rockville, MD iPSC models of chromosome 15q imprinting disorders Talk Center for Vascular Biology 2012 Farmington, CT Using Induced Pluripotent Stem Cells (iPSCs) to Study 15q Imprinting Disorders Talk Connecticut Children's Medical Center 2012 Farmington, CT Using an induced pluripotent stem cell (iPSC) model of Angelman syndrome to study the mechanism of genomic imprinting of UBE3A. Talk Angelman Syndrome Foundation 2012 Rockville, MD Human induced pluripotent stem cell (iPSC) models of chromosome 15q imprinting disorders Talk Gatlinburg Conference 2012 Annapolis, MD Human induced pluripotent stem cell (iPSC) models of Dup15q Talk Dup15q Alliance Scientific Symposium 2012 Boston, MA An induced pluripotent stem cell (iPSC) model of Angelman syndrome to study genomic imprinting at human chromosome 15q11-q13 Talk NIH/NICHHD 2011 Bethesda, MD Human iPS cell models of chromosome 15q11-q13 genomic imprinting disorders Talk Wesleyan Huges Summer Lecture Series 2011 Wesleyan University, Middletown, CT Using an iPSC model of Angelman syndrome to study genomic imprinting of UBE3A Talk Angelman syndrome foundation 2011 Salt Lake City, UT Induced pluripotent stem cell models of Angelman syndrome and autism Talk Society for Neuroscience 2011 Washington, DC iPSC models of 15q imprinting disorders Talk Center for Molecular Medicine 2011 Farmington, CT Induced pluripotent stem cell models of Angelman syndrome and autism Talk Child Neurological Society 2011 Savannah, GA iPSC models of 15q imprinting disorders Talk Rutgers University Stem Cell Center 2011 New Brunswick, NJ Stem cells to model human diseases Lecture Trinity College 2011 Hartford, CT iPSC models of chromsome 15q imprinting disorders Talk UCONN Pathobiology 2011 Storrs, CT Generation and characterization of live Angelman syndrome neurons Talk American Society for Human Genetics 2010 Washington, DC

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Stormy Chamberlain - Faculty Directory UConn Health

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Dermal fibroblast – Wikipedia

Posted: November 27, 2016 at 8:41 pm

Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury.[1] Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers.[2] Furthermore, these dermal fibroblasts produce the protein molecules including laminin and fibronectin which comprise the extracellular matrix. By creating the extracellular matrix between the dermis and epidermis, fibroblasts allow the epithelial cells of the epidermis to affix the matrix, thereby allowing the epidermal cells to effectively join together to form the top layer of the skin.

Dermal fibroblasts are derived from mesenchymal stem cells within the body.[3] Like corneal fibroblasts, dermal fibroblast proliferation can be stimulated by the presence of fibroblast growth factor (FGF).[3] Fibroblasts do not appear to be fully differentiated or specialized. After examining the CD markers of the fibroblast cells, researchers at BioMed Central discovered that these cell lack "distinctive markers" confirming that these cells can be further differentiated.[3]

One example of further differentiation of dermal fibroblasts is that upon injury, dermal fibroblasts can give rise to myofibroblasts, fibroblast cells with smooth muscle characteristics. Dermal cells differentiate into myofibroblasts by altering their actin gene expression (which is silenced in dermal fibroblasts).[4] When dermal fibroblasts express actin,the cells can slowly contract. This contraction plays a critical role in wound healing and fibrosis. By pulling tissues closed differentiated myofibroblasts, seal the skin after an injury (thereby, preventing infection but inducing scar formation.[4] Interestingly, myofibroblasts can also be derived from non-fibroblast sources. Based on evidence of -SMA expression from lung injuries, myofibroblasts can "arise de novo" directly from mesenchymal stem cells.[5]

Unlike other fibroblast cell types, dermal fibroblasts are far less likely to change into other cell types.[4] For example, when a dermal fibroblast and a corneal fibroblasts are placed in the same concentrations of fibroblast growth factor, dermal fibroblast will not differentiate or change. As noted by Dr. J. Lewis and Dr. A. Johnson authors of Microbiology of the Cell, "fibroblasts from the skin are different" and behave differently from other fibroblast cells to identical chemical stimuli.[4]

Furthermore, dermal fibroblasts are less likely to replicate in either in vivo and in vitro environments than are other fibroblast types. Dermal fibroblasts require far higher concentrations of fibroblast growth factor (FGF) in order to undergo cell replication.[4]

Dermal fibroblasts are responsible for creating the ECM which organizes the stratified squamous epithelial cells of the epidermis into a unified tissue. Furthermore, dermal fibroblasts create long fibrous bands of connective tissue which anchor the skin to the fascia of the body. Therefore, without dermal fibroblasts, the largest and heaviest organ would not tightly adhere to body's frame.

Since dermal fibroblasts play a critical role in wound healing, researchers are attempting to generate mature dermal fibroblasts to repair second and third degree burns.[6] When the body sustains a third degree burn, the skin's dermal layer is completely destroyed by heat (and the all fibroblast cells within the wound site perish. Without fibroblasts, the wound site cannot regenerate extracellular matrix and epidermis skin cells cannot proliferate over the wound site.[6] Therefore, without dermal fibroblasts the skin cannot properly recover from injury. Yet, by differentiating mesenchymal stem cells from other regions of the body and injecting them into the wound site, scientists can restore dermal fibroblasts to burned regions of the body. By restoring fibroblasts to the burned regions, the body can restore the ECM within the wound site and recover from the injury.[7] As noted "The injured dermis is also repaired by the recruitment and proliferation of fibroblasts producing extracellular matrix and keratinocyte growth promoting factors." [7]

Similarly, FGF is being inserted into fibrin sealants to enhance the long term repair and sealing of tissue.[6] FGF-1 has been experimentally shown to encourage the bodys own adhesive tissue to develop and effectively seal the wound (thereby stymieing infection and mitigating scar formation).[6] Using FGF stimulate fibroblast activity is a more effective means of sealing tissue than current tissue sealants due to the robust nature of collagen which makes up connective tissue. A study conducted by researchers at the University of Alabama examined the adhesive properties of fibrin tissue adhesives. The tests found that fibrin adhesives even at its intended medical concentration (29mg/mL at the wound site) had shear strength of only 17.6 kiloPascals.[8] Furthermore, another study performed at the University of California determined that the modulus (the stress/strain) of fibrin adhesives was on average 53.56 kPA.[9] To seal together tissues the human body uses collagen and elastin to obtain superior shear strength. Type I collagen which includes collagen strands bundled into strong fibrils has a unique tri-helical structure which increases the proteins structural integrity. In fact, a study performed by the Department of Medicine in University College London experimentally determined that pure type I collagen has a modulus of 5 GPa to 11.5 GPa.[10] Therefore, pure type I collagen has nearly one million times greater structural integrity than fibrin. Collagen is therefore much harder to deform than fibrin, and collagen fibers create much stronger bonds between tissues than strands of fibrin polymer.

By generating adhesive proteins like fibronectin, fibroblasts are used within research laboratories to help to culture cells which typically demonstrate low survival rates in vitro. For example, fibroblasts have been utilized to increase the survival rate for human stem cells which easily undergo cell apoptosis. As noted by researchers at the Harvard Stem Cell Institute, dermal cell "human keratinocyte [stem cells] could be propagated in vitro when culture on fibroblast feeder cells."[7]

In addition to improving the culture and proliferation of stem cells, dermal fibroblasts can also become stem cells. Although dermal cells demonstrate less plasticity than other fibroblast cell types, researchers can still turn these cells into induced pluripotent cells (IPCs).[7]

As noted by researchers within the Harvard Stem Cell Institute, researchers obtained fibroblasts from a mouse with sickle cell anemia and, using a virus, "reprogrammed these cells into pluripotent [stem cells], corrected the genetic deficiency by homologous recombination, and redirected these pluripotent cells toward the hematopoietic lineages, and transplanted these engineered cells to a lethally irradiated mice."[7] The animals which received the fibroblast stem cell treatment exhibited increased activity levels, indicating recovery from the disorder.[7]

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Dermal fibroblast - Wikipedia

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