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Oregon Stem Cell Center to focus on adult stem cells as …

Posted: November 20, 2016 at 7:45 am

Public release date: 23-Mar-2004 Contact: Jonathan Modie modiej@ohsu.edu 503-494-8231 Oregon Health & Science University

Oregon Stem Cell Center result of OHSU research strides New hub to focus on adult stem cells as organ transplant alternative PORTLAND, Ore. -- Oregon Health & Science University's fast-growing stem cell research program, which already has made significant strides in the hunt for human disease therapies, now has a place to call home. The multidisciplinary Oregon Stem Cell Center, the first of its kind in the Northwest, is studying cell and gene therapy as an alternative to organ transplantation for pancreatic and liver disorders, diabetes, cancer and a host of other human diseases. Its focus will be on adult stem cells.

Launched in January, the center is housed among several laboratories on the Marquam Hill Campus, but it will occupy a single floor in the 270,000-square-foot Biomedical Research Building now under construction and to be completed in fall 2005.

Its director, Markus Grompe, M.D., professor of molecular and medical genetics, and pediatrics in the OHSU School of Medicine, said the center is a hub for all areas of OHSU's rapidly expanding stem cell biology program. It aims to maximize the potential of various stem cells as therapies for human diseases through a rapid, "bench-to-bedside" approach involving basic research in stem cell biology and preclinical trials of therapies in animal models, followed by human trials.

"This is something we needed but didn't have," said Grompe, who has long studied gene and cell therapy for metabolic genetic diseases, as well as the molecular genetics of a rare, cancer-susceptibility syndrome called Fanconi anemia. "The consensus here at OHSU is that this is an area that is going to be important."

While the center's offerings will widen over time to cover other diseases -- Parkinson's disease and diabetes are considered "hot" areas of stem cell research -- it will concentrate on two areas for now and "build on that."

"My idea is to focus on the liver and the pancreas, and focus on adult stem cells," he said. "Our research already is advanced in liver reconstitution by stem cells and the repair of liver disease. We're clearly identified as one of the leaders in that area."

OHSU researchers like Grompe are wasting no time demonstrating the importance of stem cells. His laboratory is renowned as an international leader in cell therapy for liver and pancreas diseases as an alternative to organ transplantation.

Last year, Grompe published a study showing that bone marrow-derived stem cells from mice can combine with liver cells through cell fusion, which occurs when two or more cells combine to form one cell containing more genetic material than normal. The method reversed liver damage.

Other studies indicate bone marrow stem cells can meld with cells of other tissues, such as brain, spinal cord, lung, intestine and heart muscle.

The center's formation reflects a swell of research at OHSU involving stem cells. Scientists are conducting basic research, including molecular-level studies, in cardiology, endocrinology, genetics, hematology and oncology, neurology, neurological and general surgery, and reproduction.

"Basically all diseases which are currently being treated by organ transplantation are, at least on paper, amenable to cell therapy," Grompe said. "Our hope is that procedures as effective as whole organ transplantation will come out of (the center)."

Of particular interest to School of Medicine scientists are recently discovered clonally self-renewing stem cells. These unique cells have energized stem cell research - and are broadening the discipline's appeal to a larger group of scientists - because of their ability to generate copies of themselves and further divide into special-purpose offspring.

Clonally self-renewing stem cells come in several forms, such as mesenchymal stem cells, neural stem cells and multipotent progenitor cells, and can be used to create multiple cell types, including nerve cells, liver cells and muscle cells. They can be isolated from mice and primates, including humans, manipulated outside the living organism, and transplanted for reconstituting tissue.

"Their ability to be expanded in culture and then differentiated make them attractive for use in cell therapy," Grompe said.

Dan Dorsa, Ph.D., OHSU vice president for research and professor of physiology and pharmacology in the School of Medicine, said stem cells hold promise for treating many disorders. As a result, OHSU has the potential to make "a very broad impact."

"The use of stem cells for treating diseases will be at the forefront," Dorsa said. "The question we want to answer is: What is it about stem cells that allow them to be viable and take on the roles in the body you hope they will?"

The Oregon facility is one of only a handful of stem cell research centers around the country. Other sites include the University of Minnesota, Stanford University, the University of California, San Francisco, and the University of California, San Diego.

The heart of the center is three core facilities that provide cell development and management services for all campus research. They include:

-- A flow-sorting core to identify and isolate stem cell populations and characterize their progeny using fluorescence. Its primary tool, a fluorescence-activated cell sorter, "fishes out living stem cells and keeps them alive for transplantation and study," Grompe said.

-- A cell isolation core to culture, store and distribute specific stem cells. This will allow many researchers at OHSU rapid and easy access to professionally isolated and maintained, high-quality stem cell sources.

-- A monoclonal antibody production core to develop the large quantities of novel antibodies needed for identifying and purifying specific stem cells. Such a service has not been commercially available. "We'll be able to give cells to the core and get antibodies back for researchers," Grompe said. "And the antibodies don't have to be against stem cells to be effective."

The monoclonal antibody production core will be especially useful to cancer researchers, said Grover Bagby Jr., M.D., professor of molecular and medical genetics, OHSU School of Medicine, and director of the OHSU Cancer Institute.

"Having the capacity to make antibodies is going to be a nice core to have," he said. "I think a good number of cancer researchers will come to use that core. It'll be used right out of the gate."

And that could help scientists better track the progression of cancer, most forms of which are mutant outgrowths of stem cells.

"Understanding the cause of cancer definitely leads squarely into the ballpark of stem cells. We know it's true of leukemia and I suspect it's probably true of all other tissues," Bagby said. "There are a lot of things we can learn about stem cells that can lead to an understanding of how to protect them."

Dorsa and Grompe hope the center bolsters the development of OHSU-born spinoff companies while enhancing the university's partnerships with local and national biotechnology firms. It also could make OHSU more of a target for federal grants.

"There are very likely new industries that will be created by virtue of the new activity of the center," Dorsa said. The antibody core, for example, "will be attractive to commercialization."

The Oregon Stem Cell Center is funded by a three-year, $4.5 million grant from the Oregon Opportunity, the statewide, $500 million biomedical research funding initiative supported by public and private dollars. Three faculty members specializing in stem cell research also will be hired during the next two years.

Dorsa believes the Oregon Stem Cell Center fits in well with the National Institutes of Health's "Roadmap" initiative, which strives to accelerate fundamental discovery and translation of that knowledge into effective prevention strategies and new treatments.

"NIH dollars will be attracted by the stem cell center and the investments it will create," Dorsa said. "We think this one will be well positioned to compete for those dollars."

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### To access all OHSU news releases, visit http://www.ohsu.edu

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Bioheart, Inc. and Global Stem Cells, Inc. Announce New …

Posted: November 20, 2016 at 7:44 am

Global Stem Cells Group, Inc.

Miami, FL (PRWEB) November 30, 2013

Bioheart Inc., a biotech company focused on the discovery, development and commercialization of autologous cell therapies, has announced that it has initiated a new clinical site in collaboration with Global Stem Cell Group, Inc. in Cozumel, Mexico. The two companies successfully treated their first congestive heart failure patient at the new clinical site last week, using Biohearts AdipoCell (adipose derived stem cells).

The therapy involved the use of stem cells derived from the patients own fat (adipose tissue) obtained using liposuction. The recovered stem cells were injected into the patients heart with Biohearts MyoCath needle injection catheter which allows for introduction of the cells directly into the heart without invasive surgery.

Rafael Moguel, M.D., Head of the Cardiac Program at the Centro Medico de Cozumel, was the treating interventional cardiologist for the Bioheart therapy procedure.

"Our center is very excited to participate in the cutting edge programs at Bioheart," Moguel says. "We can offer new hope to patients suffering from debilitating diseases by utilizing regenerative medicine, and delivering them non-invasively into the heart."

The MyoCath catheter was introduced using a radial artery approach, the first such documented stem cell case using this delivery method. The benefit of a radial artery approach is that it does not require the patient to lie flat for up to six hours, as in a femoral artery approach. Patients are able to sit up, walk and eat immediately following the procedure, and the risk of internal bleeding is eliminated.

Bioheart and Global Stem Cells Group have designed several different protocols to be utilized at the center in Cozumel, offering treatments to patients for a variety of different indications.

About Bioheart, Inc.:

Bioheart is committed to maintaining its leading position within the cardiovascular sector of the cell technology industry delivering cell therapies and biologics that help address congestive heart failure, lower limb ischemia, chronic heart ischemia, acute myocardial infarctions and other issues. Biohearts goals are to cause damaged tissue to be regenerated, when possible, and to improve a patient's quality of life and reduce health care costs and hospitalizations.

Specific to biotechnology, Bioheart is focused on the discovery, development and, subject to regulatory approval, commercialization of autologous cell therapies for the treatment of chronic and acute heart damage and peripheral vascular disease. Its leading product, MyoCell, is a clinical muscle-derived cell therapy designed to populate regions of scar tissue within a patient's heart with new living cells for the purpose of improving cardiac function in chronic heart failure patients. For more information on Bioheart, visit http://www.bioheartinc.com, or visit us on Facebook: Bioheart and Twitter @BioheartInc.

About the Global Stem Cell Group

Global Stem Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products and solutions. Founded in 2012, the company combines dedicated researchers, physician and patient educators and solution providers with the shared goal of meeting the growing worldwide need for leading edge stem cell treatments and solutions. With a singular focus on this exciting new area of medical research, Global Stem Cells Group and its subsidiaries are uniquely positioned to become global leaders in cellular medicine.

Global Stem Cells Groups corporate mission is to make the promise of stem cell medicine a reality for patients around the world. With each of GSCGs six operating companies focused on a separate research-based mission, the result is a global network of state-of-the-art stem cell treatments.

To learn more about Global Stem Cells Group, Inc., and for investor information, visit the Global Stem Cell Group website, email bnovas(at)regenestem(dot)com, or call 305-224-1858.

Forward-Looking Statements: Except for historical matters contained herein, statements made in this press release are forward-looking statements. Without limiting the generality of the foregoing, words such as "may," "will," "to," "plan," "expect," "believe," "anticipate," "intend," "could," "would," "estimate," or "continue" or the negative other variations thereof or comparable terminology are intended to identify forward-looking statements.

Forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Also, forward-looking statements represent our management's beliefs and assumptions only as of the date hereof. Except as required by law, we assume no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future.

The Company is subject to the risks and uncertainties described in its filings with the Securities and Exchange Commission, including the section entitled "Risk Factors" in its Annual Report on Form 10-K for the year ended December 31, 2012, and its Quarterly Report on Form 10-Q for the quarter ended September 31, 2013.

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Stem Cell Research | Central Kentucky Right to Life

Posted: November 20, 2016 at 7:43 am

http://www.stemcellresearch.org

The ethical controversy surrounding human embryonic stem cell research (hESCR) arises from one fact: the research requires the destruction of a living human embryo in order to acquire the stem cells. That the human embryo is a human life is agreed upon by all sides. Indeed, if the human embryo were not a human life, and recognized as such, the research would be ethically non-contentious.

Proponents of the research base their support for it on a utilitarian proposition: the benefits such research may produce in treating numerous diseases and conditions diabetes, spinal cord injuries, Alzheimers, heart disease and Parkinsons are among the most frequently cited outweighs and justifies the necessary destruction of the embryo. The embryo is here recognized as a form of human life that is worthy of respect and the ethical concerns to which its destruction give rise are acknowledged. Nonetheless, this form of human life does not rise to a level that would require its protection whatever the potential benefits that might result from its destruction.

This outlook on embryo-destructive research was enshrined in the conditions first laid out for publicly funding such research in the United States. In its final report before he left office, President Clintons National Bioethics Advisory Committee first recommended federal funding for hESCR. But it did so conditionally: In our judgment, the derivation of stem cells from embryos remaining following infertility treatments is justifiable only if no less morally problematic alternatives are available for advancing the researchThe claim that there are alternatives to using stem cells derived from embryos is not, at the present time, supported scientifically. We recognize, however, that this is a matter that must be revisited continually as science advances.[1]

That is, the research admittedly is morally problematic precisely because it requires destroying a human life. However, the destruction of human life at the embryonic stage is justifiable because the value of that life is outweighed by the researchs potential benefits. Thus, proponents of the research begin with the possibility of therapeutic benefits to make the fact of human embryonic life conditional and therefore of lesser value than other human life.

Opponents of the research, on the other hand, begin with the fact that the human embryo, from a purely scientific perspective, is unconditionally a human life, as attested by every standard textbook on embryology. The human embryo at conception is a fully integrated, genetically unique self-directed human life that can only develop into a more mature member of the species Homo sapiens and no other. Thus, as a unique human life it has an inherent dignity and therefore cannot be used as a means to another persons ends much less another persons merely potential ends however nobly those ends are cast. In this view, human life cannot be used or manipulated to become a condition for the good of another human life.

Many who take this position, though not all, ground this inherent human dignity in the belief that the human being is created by God and possesses an eternal soul, and this dignity of the individual is thus inviolate from those who would use others as means to their own ends. Theological perspectives are legitimate and have a necessary place in considering issues of bioethics. But in addition, there are nonsectarian grounds for rejecting destructive human embryonic stem cell research, as such research represents the commodification and commercialization of human life.

Throughout the public policy debate in the United States, the main point of contention has been government funding of destructive hESCR (contrary to widespread belief, such research was never banned in the United States; the private sector was always free to pursue it and public funding at the state level was always at the discretion of the states.) The main public policy debate in the United States was whether the federal government, as a matter of national policy, should endorse embryo research by funding such ethically contentious research.) Senator Sam Brownback, a leading opponent of federal funding for hESCR, would raise the question of whether the human embryo was a person or property. From a non-sectarian standpoint, this is a crucial question in confronting the ethics of hESCR. If human life is viewed as property, than it becomes a mere commodity to be exploited for whatever purposes one deems worthy (and worthy can be as mundane as desiring smoother skin, as some cosmetic companies now boast the use of fetal cells in their preparations). This commodification and commercialization of some human life has the very real potential to degrade and diminish our sense of the inherent value of the human individual throughout all of society. For example, the pursuit of hESCR has been closely related to human cloning in order to produce embryos for stem cells theoretically genetically matched to patients. Creating and destroying a human embryo is one form of commodification of human life to produce a potential medical product. But human cloning requires human eggs, thus raising the very real specter of some women donors almost certainly lower-income and disadvantaged women being exploited as producers of a needed commodity, just as in some areas of the world the poor are exploited as donors of organs.

Nor are there any guarantees that such commodification will remain limited to embryonic life at seven days or less after conception (the time at which embryonic stem cells are usually harvested). This is because while science may be competent to tell us what we are able to do, and the most efficient way to do it, it not within the competence of science to tell us what we should or should not do. Science is a method for obtaining a specific form of knowledge about the natural world, a way of observing and learning about the physical properties of the natural world. When it comes to questions of value it is inherently neutral. Value judgments as to which avenues of medical research should or should not be pursued must come from disciplines outside of science. For example we may find that tissue taken from embryos beyond the seven-day point have greater therapeutic potential than embryonic stem cells. If that is the case, why not grow the embryo to 14 days, or 21 days, or even beyond, if from a purely scientific viewpoint that is the most efficient way to obtain the tissue most promising for treating disease? Most of us would cringe at this scenario not because of scientific reasons, but rather for ethical ones.

We have already witnessed the chilling results when some human life comes to be seen as a scientific commodity useful for conducting experiments. Researchers conducting the Tuskegee syphilis experiment (begun in 1932) believed they were acting on a sound scientific basis when they refused African-American men with syphilis the standard treatment, which then was risky and of questionable value. But they continued to deny treatment even after penicillin proved available and beneficial for syphilis patients, and they did so because of the scientific knowledge they believed they could gain from observing the diseases progression. Again, while it may have been scientifically sound for the Tuskegee researchers to carry on their study this way, we now have laws against such research because we understand it to be ethically unsound.

One final point brings us back to the condition laid down by the NBAC for conducting hESCR: that it should be pursued only if there were no less morally problematic alternatives to achieve the research goals those goals being the curing or alleviating of various diseases and conditions. Of course, opponents of the research reject any scenario for destroying human life, however noble the stated goal. But of those who would agree to such a condition, the question goes begging: is it ethically acceptable to continue such research if such ethically non-contentious alternatives are discovered? In terms of actually providing therapeutic benefits to patients, the advance of science shows adult stem cells to be far more efficacious than embryonic. To date, adult stem cells have provided therapeutic benefits to patients for some 73 diseases and conditions, while embryonic stem cells provide none.[2] And the discovery of the method to produce induced pluripotent stem cells (iPSCs) from ordinary somatic cells has given researchers an easily obtainable and virtually inexhaustible supply of fully pluripotent, embryonic-like stem cells to work with without having to destroy embryos or resort to human cloning.[3] We would argue that in light of these developments, and with these ethically non-contentious alternatives readily available, it is unethical for proponents to continue hESCR. In continuing to do so, and in devising other rationales for the research, proponents of hESCR are providing an apt illustration of how easily, once one set of ethical boundaries on scientific research are reasoned away, others soon follow.

[1] Ethical Issues in Human Stem Cell Research, National Bioethics Advisory Commission, September, 1999, p. 55

[2] Prentice DA and Tarne G, Adult versus embryonic stem cells: Treatments. Science 316, 1422-1423, 2007; also see stemcellresearch.org/facts/asc-refs.pdf for a list of sample references.

[3] Takahashi K et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell 131, 861-872, 2007; Yu J et al., Induced pluripotent stem cell lines derived from human somatic cells, Science 318, 1917-1920, 2007

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Division of Cardiovascular Medicine School of Medicine …

Posted: November 20, 2016 at 7:43 am

NewsBeat

November 4, 2016 - Dr. Gary Gibbons,Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health presented the 2016 Leonard Leight Lecture - Read More | Photos

October 24, 2016 - Drs. Rakesh Gopinathannair and Michael Flaherty lead newly approved WATCHMAN Left Atrial Appendage Closure (LAAC) Implant program at Jewish Hospital - Read More

September 29, 2016 - Dr. Aruni Bhatnagar, other health experts make case against e-cigs, hookah - Read More

August 9, 2016 - Dr. Ali. Marian tabbed to deliver the 2016 Leonard Leight Lecture - Read More

June 1, 2016 - Bradford Hill, Ph.D., was awarded a $1.8 million grant from the NIH to study the role of metabolism in cardiac cell therapy.

June 1, 2016 - Steven Jones, Ph.D., was awarded a $2.1 million grant from the NIH to study the regulation of metabolic genes in the heart.

May 18, 2016 - Aruni Bhatnagar, Ph.D., and the UofL Diabetes & Obesity Center are part of an air pollution reduction project - Read More

Oct. 29, 2015 - Roberto Bolli, M.D., FAHA, honored with the Schottenstein Prize in Cardiovascular Sciences from The Ohio State University - Read More

Incredible! That's how Mike Jones describes his life three and a half years after receiving stem cells as part of Dr. Roberto Bolli's groundbreaking SCIPIO trial. The study, in which twenty patients received their own cardiac stem cells, has transformed Mike Jones' life.Read more.

November 15, 2016 - Dr. Emma Birks presents evidence showing that an artificial heart assist device along with medications may actually help heal the heart - Read More

October 25, 2016 -UofL research team co-authors American Heart Association Rapid Access Journal Report on air pollution linked to blood vessel damage in healthy young adults - Read More

September 27, 2016 - Dr. Aruni Bhatnagar part of Mayor's forum on possible e-cigarette, hookah ban - Read More

August 12, 2016 - Participants sought by UofL for FACTT trial researching e-cigarette flavors. For more information, e-mail ATRAC@louisville.edu - Read More

April 25, 2016 - Dr. Lorrel Brown earns American College of Cardiology award for CPR training at the Kentucky State Fair - Read More

April 12, 2016 - Dr. Andrew DeFilippis was recently honored with the Multi-Ethnic Study of Atherosclerosis (MESA) Early Career Investigator Award - Read More

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Stem Cell Therapy – Honolulu Hawaii – Infinity Life Center

Posted: November 20, 2016 at 7:43 am

Infinity Life Center and the Hawaii Stem Cell Treatment Center in Honolulu are proud to provide public access to regenerative stem cell based medicine. The Hawaii Stem Cell Treatment Center currently follows an in office, out patient, strict sterile closed surgical procedure to harvest and process fat into differentiated stem cells under local anesthesia. These protocols are set forth by the Cell Surgical Network, an international group of highly qualified and credentialed physicians committed to clinical research for the advancement of regenerative medicine.

Stem cell therapy has clinical applications and the potential to treat several degenerative conditions, diseases and injuries. Stem cells are currently being used for cosmetic application as well as to treat orthopedic injuries, heart & lung disease, autoimmune disease, neurologic disease, urological disease and ophthalmological disease.

Many of these treatments are in their infancy but there is very strong support, data and experience to indicate the efficacy of stem cell therapy in several areas.

To enlist in our treatment program or find out if your a good candidate for stem cell therapy contact us for a consultation.

Stem Cells & the FDA

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Stem Cell Therapy - Honolulu Hawaii - Infinity Life Center

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Nanobiotechnology – Wikipedia

Posted: November 19, 2016 at 3:43 pm

Nanobiotechnology, bionanotechnology, and nanobiology are terms that refer to the intersection of nanotechnology and biology.[1] Given that the subject is one that has only emerged very recently, bionanotechnology and nanobiotechnology serve as blanket terms for various related technologies.

This discipline helps to indicate the merger of biological research with various fields of nanotechnology. Concepts that are enhanced through nanobiology include: nanodevices (such as biological machines), nanoparticles, and nanoscale phenomena that occurs within the discipline of nanotechnology. This technical approach to biology allows scientists to imagine and create systems that can be used for biological research. Biologically inspired nanotechnology uses biological systems as the inspirations for technologies not yet created.[2] However, as with nanotechnology and biotechnology, bionanotechnology does have many potential ethical issues associated with it.

The most important objectives that are frequently found in nanobiology involve applying nanotools to relevant medical/biological problems and refining these applications. Developing new tools, such as peptoid nanosheets, for medical and biological purposes is another primary objective in nanotechnology. New nanotools are often made by refining the applications of the nanotools that are already being used. The imaging of native biomolecules, biological membranes, and tissues is also a major topic for the nanobiology researchers. Other topics concerning nanobiology include the use of cantilever array sensors and the application of nanophotonics for manipulating molecular processes in living cells.[3]

Recently, the use of microorganisms to synthesize functional nanoparticles has been of great interest. Microorganisms can change the oxidation state of metals. These microbial processes have opened up new opportunities for us to explore novel applications, for example, the biosynthesis of metal nanomaterials. In contrast to chemical and physical methods, microbial processes for synthesizing nanomaterials can be achieved in aqueous phase under gentle and environmentally benign conditions. This approach has become an attractive focus in current green bionanotechnology research towards sustainable development.[4]

The terms are often used interchangeably. When a distinction is intended, though, it is based on whether the focus is on applying biological ideas or on studying biology with nanotechnology. Bionanotechnology generally refers to the study of how the goals of nanotechnology can be guided by studying how biological "machines" work and adapting these biological motifs into improving existing nanotechnologies or creating new ones.[5][6] Nanobiotechnology, on the other hand, refers to the ways that nanotechnology is used to create devices to study biological systems.[7]

In other words, nanobiotechnology is essentially miniaturized biotechnology, whereas bionanotechnology is a specific application of nanotechnology. For example, DNA nanotechnology or cellular engineering would be classified as bionanotechnology because they involve working with biomolecules on the nanoscale. Conversely, many new medical technologies involving nanoparticles as delivery systems or as sensors would be examples of nanobiotechnology since they involve using nanotechnology to advance the goals of biology.

The definitions enumerated above will be utilized whenever a distinction between nanobio and bionano is made in this article. However, given the overlapping usage of the terms in modern parlance, individual technologies may need to be evaluated to determine which term is more fitting. As such, they are best discussed in parallel.

Most of the scientific concepts in bionanotechnology are derived from other fields. Biochemical principles that are used to understand the material properties of biological systems are central in bionanotechnology because those same principles are to be used to create new technologies. Material properties and applications studied in bionanoscience include mechanical properties(e.g. deformation, adhesion, failure), electrical/electronic (e.g. electromechanical stimulation, capacitors, energy storage/batteries), optical (e.g. absorption, luminescence, photochemistry), thermal (e.g. thermomutability, thermal management), biological (e.g. how cells interact with nanomaterials, molecular flaws/defects, biosensing, biological mechanisms s.a. mechanosensing), nanoscience of disease (e.g. genetic disease, cancer, organ/tissue failure), as well as computing (e.g. DNA computing)and agriculture(target delivery of pesticides, hormones and fertilizers.[8] The impact of bionanoscience, achieved through structural and mechanistic analyses of biological processes at nanoscale, is their translation into synthetic and technological applications through nanotechnology.

Nano-biotechnology takes most of its fundamentals from nanotechnology. Most of the devices designed for nano-biotechnological use are directly based on other existing nanotechnologies. Nano-biotechnology is often used to describe the overlapping multidisciplinary activities associated with biosensors, particularly where photonics, chemistry, biology, biophysics, nano-medicine, and engineering converge. Measurement in biology using wave guide techniques, such as dual polarization interferometry, are another example.

Applications of bionanotechnology are extremely widespread. Insofar as the distinction holds, nanobiotechnology is much more commonplace in that it simply provides more tools for the study of biology. Bionanotechnology, on the other hand, promises to recreate biological mechanisms and pathways in a form that is useful in other ways.

Nanomedicine is a field of medical science whose applications are increasing more and more thanks to nanorobots and biological machines, which constitute a very useful tool to develop this area of knowledge. In the past years, researchers have done many improvements in the different devices and systems required to develop nanorobots. This supposes a new way of treating and dealing with diseases such as cancer; thanks to nanorobots, side effects of chemotherapy have been controlled, reduced and even eliminated, so some years from now, cancer patients will be offered an alternative to treat this disease instead of chemotherapy, which causes secondary effects such as hair loss, fatigue or nausea killing not only cancerous cells but also the healthy ones. At a clinical level, cancer treatment with nanomedicine will consist on the supply of nanorobots to the patient through an injection that will seek for cancerous cells leaving untouched the healthy ones. Patients that will be treated through nanomedicine will not notice the presence of this nanomachines inside them; the only thing that is going to be noticeable is the progressive improvement of their health.[9]

Nanobiotechnology (sometimes referred to as nanobiology) is best described as helping modern medicine progress from treating symptoms to generating cures and regenerating biological tissues. Three American patients have received whole cultured bladders with the help of doctors who use nanobiology techniques in their practice. Also, it has been demonstrated in animal studies that a uterus can be grown outside the body and then placed in the body in order to produce a baby. Stem cell treatments have been used to fix diseases that are found in the human heart and are in clinical trials in the United States. There is also funding for research into allowing people to have new limbs without having to resort to prosthesis. Artificial proteins might also become available to manufacture without the need for harsh chemicals and expensive machines. It has even been surmised that by the year 2055, computers may be made out of biochemicals and organic salts.[10]

Another example of current nanobiotechnological research involves nanospheres coated with fluorescent polymers. Researchers are seeking to design polymers whose fluorescence is quenched when they encounter specific molecules. Different polymers would detect different metabolites. The polymer-coated spheres could become part of new biological assays, and the technology might someday lead to particles which could be introduced into the human body to track down metabolites associated with tumors and other health problems. Another example, from a different perspective, would be evaluation and therapy at the nanoscopic level, i.e. the treatment of Nanobacteria (25-200nm sized) as is done by NanoBiotech Pharma.

While nanobiology is in its infancy, there are a lot of promising methods that will rely on nanobiology in the future. Biological systems are inherently nano in scale; nanoscience must merge with biology in order to deliver biomacromolecules and molecular machines that are similar to nature. Controlling and mimicking the devices and processes that are constructed from molecules is a tremendous challenge to face the converging disciplines of nanotechnology.[11] All living things, including humans, can be considered to be nanofoundries. Natural evolution has optimized the "natural" form of nanobiology over millions of years. In the 21st century, humans have developed the technology to artificially tap into nanobiology. This process is best described as "organic merging with synthetic." Colonies of live neurons can live together on a biochip device; according to research from Dr. Gunther Gross at the University of North Texas. Self-assembling nanotubes have the ability to be used as a structural system. They would be composed together with rhodopsins; which would facilitate the optical computing process and help with the storage of biological materials. DNA (as the software for all living things) can be used as a structural proteomic system - a logical component for molecular computing. Ned Seeman - a researcher at New York University - along with other researchers are currently researching concepts that are similar to each other.[12]

DNA nanotechnology is one important example of bionanotechnology.[13] The utilization of the inherent properties of nucleic acids like DNA to create useful materials is a promising area of modern research. Another important area of research involves taking advantage of membrane properties to generate synthetic membranes. Proteins that self-assemble to generate functional materials could be used as a novel approach for the large-scale production of programmable nanomaterials. One example is the development of amyloids found in bacterial biofilms as engineered nanomaterials that can be programmed genetically to have different properties.[14]Protein folding studies provide a third important avenue of research, but one that has been largely inhibited by our inability to predict protein folding with a sufficiently high degree of accuracy. Given the myriad uses that biological systems have for proteins, though, research into understanding protein folding is of high importance and could prove fruitful for bionanotechnology in the future.

Lipid nanotechnology is another major area of research in bionanotechnology, where physico-chemical properties of lipids such as their antifouling and self-assembly is exploited to build nanodevices with applications in medicine and engineering.[15]

Meanwhile, nanotechnology application to biotechnology will also leave no field untouched by its groundbreaking scientific innovations for human wellness; the agricultural industry is no exception. Basically, nanomaterials are distinguished depending on the origin: natural, incidental and engineered nanoparticles. Among these, engineered nanoparticles have received wide attention in all fields of science, including medical, materials and agriculture technology with significant socio-economical growth. In the agriculture industry, engineered nanoparticles have been serving as nano carrier, containing herbicides, chemicals, or genes, which target particular plant parts to release their content.[16] Previously nanocapsules containing herbicides have been reported to effectively penetrate through cuticles and tissues, allowing the slow and constant release of the active substances. Likewise, other literature describes that nano-encapsulated slow release of fertilizers has also become a trend to save fertilizer consumption and to minimize environmental pollution through precision farming. These are only a few examples from numerous research works which might open up exciting opportunities for nanobiotechnology application in agriculture. Also, application of this kind of engineered nanoparticles to plants should be considered the level of amicability before it is employed in agriculture practices. Based on a thorough literature survey, it was understood that there is only limited authentic information available to explain the biological consequence of engineered nanoparticles on treated plants. Certain reports underline the phytotoxicity of various origin of engineered nanoparticles to the plant caused by the subject of concentrations and sizes . At the same time, however, an equal number of studies were reported with a positive outcome of nanoparticles, which facilitate growth promoting nature to treat plant.[17] In particular, compared to other nanoparticles, silver and gold nanoparticles based applications elicited beneficial results on various plant species with less and/or no toxicity.[18][19] Silver nanoparticles (AgNPs) treated leaves of Asparagus showed the increased content of ascorbate and chlorophyll. Similarly, AgNPs-treated common bean and corn has increased shoot and root length, leaf surface area, chlorophyll, carbohydrate and protein contents reported earlier.[20] The gold nanoparticle has been used to induce growth and seed yield in Brassica juncea.[21]

This field relies on a variety of research methods, including experimental tools (e.g. imaging, characterization via AFM/optical tweezers etc.), x-ray diffraction based tools, synthesis via self-assembly, characterization of self-assembly (using e.g. MP-SPR, DPI, recombinant DNA methods, etc.), theory (e.g. statistical mechanics, nanomechanics, etc.), as well as computational approaches (bottom-up multi-scale simulation, supercomputing).

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Integrative Medicine > Lee Health

Posted: November 19, 2016 at 3:43 pm

Why Choose Us We Believe in a World of Wellness

Our Integrative Medicine specialists take a whole person approach to health and wellness. We believe that health is dynamic, continually influenced by how we live our lives and how we relate to the world around us. And, we believe that healing starts from within.

From the moment you walk through our doors, you sense that the integrative approach is unlike any other. We blend evidence-based complementary and alternative therapies with conventional Western medicine in a best of both worlds approach to treating disease, healing, and improving health.

Because there is no magic pill for health and well-being, the road to healing requires a diverse, collaborative team of integrative medicine professionals dedicated to treating mind, body and spirit.

With a fellowship trained physician and our licensed and certified practitioner in allopathic and alternative medicine, the centers specialists are at the forefront of integrative medicine.

We care for people with diabetes, womens health issues, stress, and many other health concerns.

We empower you to promote your own healing with a full range of conventional and complementary treatments and therapies. Through clinical research, education, prevention, and lifestyle changes, youll discover powerful new ways to take control of your health.

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Integrative Medicine: Trends and Beliefs – decodedscience.org

Posted: November 19, 2016 at 3:43 pm

Ayurvedic Medicine has been practiced in India for thousands of years. Image by GaborfromHungary

How does Western medical philosophy combine with less-traditional medical beliefs? Thanks to multiculturalism, Integrative Medicine is becoming more mainstream among practitioners.

During the second half of the twentieth century, the concept of multiculturalism (i.e.- the coexistence of cultural and religious diversity) as a positive influence on society became widespread.

Westerners, in particular, began exploring many aspects of other cultures, and many developed an open-minded approach to adopting such cultural artifacts and practices as styles of music and fashion, yoga, meditation, and non-Western traditional medical systems.

With the expansion of globalization in the late twentieth century, non-Western medical practices such as Traditional Chinese Medicine started to enter the mainstream. Thus, in the late 1990s, the field of Integrative Medicine (also called Integrated Medicine)became established in the USA.

Integrative Medicineis based on the principle that no single medical system is perfect, and that combining elements of various medical systems in an intelligent and informed manner achieves and maintains better health.

CAM is the acronym for Complementary and Alternative Medicine. It is the most frequently used term in the USA to denote the combined use of Western (conventional) medicine with different medical systems.

The terms CAM and Integrative Medicine (or Integrated Medicine) express the most basic principle of this approach to health: that of using or integrating several medical systems in a complementary manner. Conventional Western medicine is not rejected, nor are alternative medical systems used uncritically.

The basic principles of Integrative Medicine include the beliefthat health and well-being are the most natural conditions, and that the human body has an inborn ability to heal itself. Practitioners believe that medical intervention should support and facilitate that ability. The most effective treatments, they say, are therefore those that are most natural and least invasive.

Doctors who practice various alternative medicine techniquesbelieve that medical caregiversshould individualize and personalize all treatment. There is a strong belief that no one-size-fits-all treatment exists for any medical condition or illness. Medical treatment should treat the person, rather than the disease, and therefore the doctor should base treatmenton the unique individual traits and needs of the patient.

Furthermore, both doctors of Western Medicine (MDs) and doctors of Oriental Medicine (OMDs) agree thata healthy diet and lifestyle maintains and supports good health, so the individual needs to take an active role in the prevention of illness.

Integrative Medicine holds that, since the mind andthe body are not separate entities, emotional and social factors influence ones health.

Whereas, in the past, people viewed the doctor as the only genuine medical authority, Integrative Medicine holdsthat the patient seeking help is the authentic expert on his/her own health, having lived inside his/her own body for a whole lifetime.

Supporters of Integrative Mediconetherefore consider thepatient and the medical professional as partners in the healing process. The role of the medical professional is to diagnose and recommend possible treatments, rather than to maintain that only one treatment is available or desirable. The patient thus has the ultimate control in deciding which treatment would be most appropriate and beneficial. This is known as patient empowerment.

Traditional Chinese Medicine takes the various meridians of the human body into account for health and massage. Image by KVDP

Throughout the 1990s, experts conducted research on the use of CAM/Integrative Medicine in the USA. One survey, published in theJournal of the American Medical Association, indicated that visits to alternative medicine practitioners increased from 427 million in 1990 to 629 million in 1997. This was greater than the number of visits to all US primary care physicians.

The Osher Center for Integrative Medicine at the University of California, San Francisco, provides the following information on the development of integrative medicine in the USA from 1992 to 2004:

In 1992, the Office of Alternative Medicine (OAM) was founded as part of the National Institutes of Health (NIH). Its annual budget was $2 million. In 1998, the OAM was renamed the National Center for Complementary and Integrative Health(NCCIH). NCCIHs budget for research in 2005 was $121 million, reflecting the growing popularity and acceptance of CAM/Integrative Medicine.

In 2002, a survey of 31,000 American adults revealed that 38% 62% used CAM during the preceding year (depending on the types of treatmentsincluded in the definition of CAM).

Not only has the popularity of Integrative Medicine grown among patients, but the acceptance of various integrated medical practices has become widespreadamong Western medical professionals in recent years, as well. For example, in 2005, the Institute of Medicine of the National Academies recommended that health profession schools should incorporate information about CAM into the standard curriculum, so that licensed professionals would be able to advise their patients about it.

Integrative Medicine acknowledges that medicinemustbe based on scientific inquiry. Many non-Western medical systems have developed outside of a rigorous scientific context.

Nowadays, the National Center for Complementary and Integrative Health(NCCIH) requires the testing of non-Western medical practices by Western research standards. This is meant to guarantee that non-Western medical treatments are both safe and effective.

The backbone of Western medicine is research thatprofessionalscan replicate and validate over and over again by objective standards.

Nowadays, the various medical traditions that comprise the field of Integrative Medicine are all being subjected to this kind of objective analysis. The results of current research will pave the way to greater integration of the various medical traditions in the future. In this way, doctors will tailor health practicesto meet the very specific needs of each individual patient.

Dr. Andrew Weill is a medical doctor, teacher, and writer of many books and articles on holistic health. He is the founder and director of the Arizona Center for Integrative Medicine at the University of Arizona, where he teaches. Weill defines Integrative Medicine as the intelligent combination of Western and alternative medicine He views it as the best of both worlds.

Brad Lemley sums up the philosophy of Integrative Medicinewhen he saysthat this approach to medicine cherry picks the best scientifically validated therapies that conventional Western and alternative medical systems have to offer.

When it comes to your health, shouldnt every person should have to right to choose and enjoy the best resourcesgathered and perfected throughout human history?

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Integrative Medicine – sciencenewsbooks.science

Posted: November 19, 2016 at 3:43 pm

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Integrative Medicine Clinic in Churchton, MD

Posted: November 19, 2016 at 3:43 pm

Integrative Medical Approach

Integrative medicine places the patient at the center of a holistic approach to medical care. Patient's individual needs, risks, and goals are the main driving forces of any integrative therapy. Physicians practicing integrative medicine emphasize that treatment of every aspect of a person's health is crucial to the success of the healing process:

To request more information, please contact our Churchton integrative medicine clinic today! Call (410) 567-0667 or contact Annapolis Integrative Medicine Clinic online.

Integrative medicine is a multi-disciplinary approach that combines the scientific advances and a variety of effective therapies to treat disease.

Integrative medicine combines conventional and complementary treatment options to achieve optimal health for the patient. It is based on the research which demonstrates that the human body has an innate healing mechanism. Illness occurs when the regenerative processes in the body are disturbed, and the body can no longer keep itself healthy.

Integrative medicine emphasizes the use of the least invasive treatment options necessary to bring the body to a healthy state.

Integrative medicine physicians focus on health optimization and often combine a variety of methods to optimize their patients' health:

To request more information, please contact our Churchton integrative medicine clinic today! Call (410) 567-0667 or contact Annapolis Integrative Medicine Clinic online.

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