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WISCONSIN STEM CELL SYMPOSIUM – BTC Institute

Posted: October 1, 2015 at 6:48 pm

Image courtesy of James Monaghan, Ph.D., Northeastern University, Boston, MA

BioPharmaceutical Technology Center 5445 East Cheryl Parkway Fitchburg/Madison, WI 53711 MAP & DIRECTIONS

OVERVIEW: The Symposium was coordinated by the Stem Cell & Regenerative Medicine Center, at the University of Wisconsin-Madison and the BTC Institute. It brought together leading researchers who are working in the areas of limb development and regeneration (morning session) and stem cells and tissue engineering (afternoon session).

HIGHLIGHTED ISSUES:

PRESENTERS

Jeremy Brockes, Ph.D., MRC Research Professor, Department of Structural and Molecular Biology, University College London, London, UK

David Butler, Ph.D., Emeritus Professor, Biomedical Engineering, University of Cincinnati, Cincinnati, OH

John Fallon, Ph.D., H.W. Mossman Professor Emeritus, Cell and Regenerative Biology Department, University of Wisconsin-Madison, Madison, WI (Moderator)

Johnny Huard, Ph.D., Professor, Departments of Orthopaedic Surgery, Microbiology and Molecular Genetics, Bioengineering, Pathology, Pediatrics, and Physical Medicine and Rehabilitation; Director of the Stem Cell Research Center, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA

Mayumi Ito, Ph.D., Associate Professor, The Ronald O. Perelman Department of Dermatology, Department of Cell Biology, New York University School of Medicine, New York, NY

Timothy J. Kamp, M.D., Professor, Medicine; Co-director, Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison (Welcome)

Lisa Larkin, Ph.D., Associate Professor, Molecular & Integrative Physiology, Biomedical Engineering Department, University of Michigan, Ann Arbor, MI

Wan-Ju Li, Ph.D., Assistant Professor, Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, Madison, WI

William Murphy, Ph.D., Harvey D. Spangler Professor, Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Madison, WI

David Stocum, Ph.D., Professor and Dean Emeritus, Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN

Koji Tamura, Ph.D., Professor, Laboratory of Organ Morphogenesis, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan

Panagiotis Tsonis, Ph.D., Professor, College of Arts and Sciences: Biology, and School of Engineering: Bioengineering Graduate Program; Director, Center for Tissue Regeneration and Engineering, University of Dayton, Dayton, OH

Ray Vanderby, Ph.D., Professor of Biomedical Engineering & Professor of Orthopedic Surgery, University of Wisconsin-Madison, Madison, WI (Moderator)

SCHEDULE

ABSTRACTS

POSTER SESSION ABSTRACTS Congratulations to our Poster Contest winners: Thomas Lozito (1st place), David Belair (2nd place) and Ethan Lippmann (3rd place)!

For information regarding other past symposia, please visit our ARCHIVE

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WISCONSIN STEM CELL SYMPOSIUM - BTC Institute

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1. Embryonic Stem Cells [Stem Cell Information]

Posted: October 1, 2015 at 6:48 pm

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How Stem Cells Work – HowStuffWorks

Posted: October 1, 2015 at 6:48 pm

Many diseases kill cells within organs, claiming lives or impairing a person's ability to live a normal life. For example, about 5.8 million Americans have heart failure and 670,000 people are diagnosed with it each year [source: Centers for Disease Control]. In heart failure, much of the heart muscle itself dies, so the heart cannot sufficiently pump blood.

Similarly, about 23.6 million Americans have diabetes [source: NIDDK, NIH]. Five to 10 percent of these people have Type I diabetes in which the insulin-producing cells of the pancreas are dead. Finally, about 1 million Americans live with Parkinson's disease [source: Parkinson's Disease Foundation]. In this disease, cells that make the neurotransmitter dopamine, which helps control movement, die. Patients with Parkinson's disease have tremors and uncontrollable movements. But what if these dead cells could be replaced with fresh cells? Could the patients be treated and live normal lives? That's the goal of stem cell research.

In this article, we'll look at stem cells, starting with the accompanying picture above. In the photo, the embryonic stem cell colonies are the rounded, dense masses of cells. The flat elongated cells are fibroblasts used as "feeder cells." We'll also find out how stem cells work, discover their potential to treat disease and get inside the ongoing debate surrounding their research and use. But first, let's cover some basics.

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SPERMATOGENESIS University of Wyoming

Posted: October 1, 2015 at 6:48 pm

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Natural Breast Augmentation Scottsdale | Stem Cell Breast …

Posted: October 1, 2015 at 6:48 pm

Stem Cell Breast Augmentation fees estimate between $18,000.00 to $22,000.00. There are several factors that determine the fee schedule such as the number of areas being treated, procedure time and overall goals.

Click Here to Read FAQ's

Dr Malan's Stem Cell Enhanced Natural Breast Augmentation uses a patients's fat tissue, which is a rich source of stem cells and regenerative cells, to provide women the option of enlarging their breast without the use of unnatural implants. These stem cells are not the controversial embryonic stem cells.

First, the Body-Jet liposuction device utilizes streaming water to gently harvest the fat. The fat is then processed to extract and activate the stem cells. The stem cells are then concentrated with the fat and injected in the breast. The injection of the fat along with the stem cells results in a permanent 250cc to 500cc overall breast size increase, which is a 1 or 2 bra cup size increase. A pressure splint is sometimes used after the procedure to ensure that the fat remains in place and assists in promoting regeneration of the transferred fat and stem cells.

The end result is enlarged breasts that are very natural in appearance and feel without the complications associated with implants. Unlike traditional implants, this procedure will not interfere with future Mammograms or breastfeeding. The technique does not require general anesthesia, typically requires only 48 hour recovery period and leaves permanent results.

Dr. Todd Malan - First in U.S. to perform Stem Cell Enhanced Breast Augmentation! READ FULL ARTICLE

Using Stem Cells in Breast Augmentation - Interview with Dr. Todd Malan READ FULL ARTICLE

Q: I have heard that this procedure is controversial? A: For 20 years the major U.S. Cosmetic Surgery society denounced Fat Transfer to the Breast as a dangerous procedure. This decision was based on technology and techniques used 20 years ago. Recent developments and results from our patients prompted the recent lift on this ban in March 2009. Many Cosmetic Surgeons are unaware of the new and improved techniques or of the recent lifting of this ban and still advise patients against this procedure. The common myths you will hear from doctors who have not followed these recent changes are;

Q: Who is the ideal candidate? A: Anyone who desires a permanent increase in breast size that is natural in appearance. The Natural Breast Augmentation is ideal for the person who has lost fullness in her breast due to age, weight fluctuations, and breast feeding. A 1-2 cup size increase and more fullness are expected from this procedure. However the person who would not be happy with anything less that a 2-3 cup size increase should consider Breast Implants.

Q: I read most of the fat doesn't survive so more than one surgery is needed? A: New techniques have proven an 85-90% fat survival. Stem cell techniques in Europe and Japan have shown fat survival to be even higher. The alternative breast implants need to be replaced every 10 years and problems such as scarring and rupture are common.

Q: I heard calcifications caused by the surgery can interfere with mammograms? A: Studies have proven that newer digital mammograms can easily evaluate calcifications in the breast whereas the alternative enhancement procedure, Breast Implants, block more than half of the breast from the view of mammograms.

Q: Is this similar to the Stem Cell Breast Augmentations being used in Japan? A: Yes, we offer stem cell enhanced fat transfer which has been proven in Europre and Japan to improve fat survival.

Q: Why should I chose Dr. Todd Malan? A: Since the recent lifting of the ban on this procedure many doctors have begun offering fat transfer to the breast surgery. The lift on the ban was due in part to Dr. Malan's improved technique and Dr. Malan trains doctors world wide in his procedure. In fact Dr. Malan is the first certified training course for doctors in the U.S. Unless the doctor has been trained by Dr. Malan they are likely using old techniques that caused the ban 20 years ago.

Q: What if I don't really need liposuction but still want a Natural Breast (Stem Cell) Augmentation? A: Dr. Todd Malan is dedicated to not only giving you natural looking breasts but also great liposuction results. Patients travel from all over the world to have their liposuction procedure performed by Dr. Malan. The stem cell procedure allows Dr. Malan to use far less fat to achieve great results.

1: Body-Jet Water Liposuction gently removes fat, regenerative, and stem cells from abdomen. 2: Cells go into the Stem Cell processing system. 3: The Stem Cell processing system separates regenerative and stem cells from fat cells. The regenerative and stem cells are then washed and concentrated. 4: The concentrated stem cell mixture is combined with the fat cells. 5: The final mixture is injected into the breast, where it replaces tissue volume.

The Stem Cells when injected may the help to:

*Regenerative and Stem Cell information presented is based on clinical studies conducted in Europe and Asia. Current U.S. studies are underway.

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HCG Diet | How Does the HCG Diet Work | HCG Diet Dangers

Posted: October 1, 2015 at 6:47 pm

UPDATE: See our interview: hCG Diet Reviewed by FullBars Dr. Michael Snyder

You wont see me promoting quick fixes or fad diets anytime soon. But every once in awhile something comes along that seems so dangerous I have to call it out. Thats why Im going to help reveal the truth behind the HCG diet.

What it is: HCG (human chorionic gonadotropin) is a hormone produced during pregnancy by the cells that form the placenta. This hormone is detected in the blood around 11 days after conception; it is detected in the urine around 12-14 days after conception. While it is most commonly associated with pregnancy, it is present in both genders.

What it does in the body: HCG signals the hypothalamus (area of the brain that affects metabolism) to mobilize fat stores. In pregnancy, this helps the body bring nutrients into the placenta, fueling the fetus with the energy to grow.

The weight loss claim: The HCG diet (using daily hcg injections) will help you lose 1-3 pounds per day. The HCG-diet combines the daily injections with a very low-calorie diet (500 calories per day).

500-calories per day is severely restrictive! In fact, it is not enough calories to support normal brain function. Your body will compensate by using stores of glycogen, protein (muscle) and some fat, which lowers your resting metabolism. Before you can lose true weight, you will be so irritable, lightheaded, and cranky that youll reach for whatever food you can get your hands on and have a field day.

Scientific evidence: There is no scientific evidence supporting HCG injections as a weight loss strategy. In addition, these injections have not been approved by the FDA for use in weight loss. In fact, since 1975 the FDA has required all marketing and advertising of HCG to state the following: HCG has not been demonstrated to be effective adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or normal distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets.

HCG is a hormone extracted from urine of pregnant women. It is approved by FDA for treatment of certain problems of the male reproductive system and in stimulating ovulation in women who have had difficulty becoming pregnant. No evidence has been presented, however, to substantiate claims for HCG as a weight-loss aid. via the FDA

HCG ban: The hormone was recently added to the list of banned substances in Major League Baseball, as it was becoming increasingly popular among steroid users. Athletes turned to this, among other performance enhancing drugs because it mitigates the side effects of ending a cycle of steroids.

Negative side effects: The common side effects include headaches, mood swings, depression, blood clots, confusion, and dizziness. Some women also develop a condition called Ovarian Hyperstimulation Syndrome (OHSS); symptoms of this include pelvic pain, swelling of the hands and legs, stomach pain, weight gain, shortness of breath, diarrhea, vomiting/nausea, and/or urinating less than normal.

Remember, if it sounds too good to be true, it usually is. Weight loss is hard work and it wont come in a potion, pill, or injection. The most dangerous thing you should be doing to your body is trying a new exercise that intimidates you like rock climbing or completing a marathon.

Sources: Banned in MLBHCG Side EffectsFDA CalorieLab : Weight loss is hard, and human pregnancy hormone wont change that Associated Content : HCG Marketed by convicted fraud, Kevin Trudeau Diet Scam Watch : HCG Worthless as a weight-loss aid

July 28th, 2009

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HCG Diet | How Does the HCG Diet Work | HCG Diet Dangers

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Hormone Replacement Therapy Doctor | Genemedics

Posted: October 1, 2015 at 6:47 pm

Genemedics Health Institute is the national leader in bioidentical hormone replacement therapy for men (BHRT for men) and bioidentical hormone replacement therapy for women (BHRT for women). Led by nationally renowned Dr. George Shanlikian, M.D., Genemedics Health Institutes physician experts specialize in natural bioidentical hormone replacement therapy (BHRT), personalized nutrition programs, nutritional supplements, and fitness for both men and women.

Genemedics bioidentical hormone programs are customized for each individual to alleviate symptoms associated with:

Bioidentical hormones that may need to be balanced include:

All of our physicians are board-certified in Anti-Aging and Regenerative Medicine through the American Academy of Anti-Aging Medicine (A4M). Our expert physicians have passed written and oral exams and are among the most knowledgeable physicians in the field of anti-aging and natural hormone replacement therapy. Our natural hormone replacement therapy doctors have also completed advanced fellowships in Anti-Aging and Regenerative Medicine, completing hundreds of hours of additional training in anti-aging medicine and bioidentical hormone replacement therapy.

Genemedics' physician-supervised health program consists of natural bioidentical hormone replacement therapy, along with a nutrition plan, nutritional supplement regimen, and exercise program customized to help you reach your health and fitness goals.We have seen astonishing results in the lives of our patients, who are healthier, happier, and have dramatically improved quality of life. We incorporate functional testing such as body fat assessment, fitness testing, and stretch testing to gauge patient progress. We pay close attention to detail and routinely follow up with complete lab panels to make sure you have obtained and maintain hormone balance, along with optimal health and wellness. Our comprehensive natural bioidentical hormone replacement therapy programs, combined with proper nutrition and exercise, will return you to the optimal physical, sexual, and emotional health you experienced in your twenties and thirties. Contact us today and get started on the path to a younger, healthier you!

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Hormone Replacement Therapy Doctor | Genemedics

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News | Mormon Transhumanist Association

Posted: October 1, 2015 at 6:46 pm

The Mormon Transhumanist Association is pleased to announce that it has appointed Dorothy Deasy to serve as Chief Humanitarian Officer. Dorothy will continue to serve in her positions as board member and secretary of the board. Humanitarian managers, Hank Pellissier and Roger Hansen, will also continue to serve in their positions.

The Association engages in humanitarian efforts for a variety of reasons. Partly it is because the projects reflect the motivations and passions of their respective project leaders, such Hank Pellissier's desire to help people in Uganda to reach their potential, Kathy Wilson's hope to ease the hardship of dalits in India, or Roger Hansen's work to bring joy to children growing up in poverty in Africa. The over-arching reason is that we are inspired by the idea of transfiguration and aspire to follow the example of Christ by reaching out with love.

Dorothy believes that transfiguration calls us both to traditional expressions of charity and to more. Her hope is that the Association will influence many to imagine the promise of transhuman advances and technology as an opportunity to provide greater access to those on the margins, and to position anticipation of the Technological Singularity as an urgent reason for work to ensure that all human potential matters.

The Mormon Transhumanist Association is eager to work with others on projects that enable people to participate in their own transformation and that of their communities for the better. We need your help, resources, passions, and projects. Join us to ensure emerging technologies are applied where and how they are most needed in our society, culture, and world.

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News | Mormon Transhumanist Association

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Nick Bostrom's Home Page

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Epigenetics: Fundamentals | What is Epigenetics?

Posted: October 1, 2015 at 6:46 pm

Technical Readership Level:

What is Epigenetics?

The term epigenetics refers to heritable changes in gene expression (active versus inactive genes) that does not involve changes to the underlying DNA sequence; a change in phenotype without a change in genotype. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. Or, epigenetic change can have more damaging effects that can result in diseases like cancer. At least three systems including DNA methylation, histone modification and non-coding RNA (ncRNA)-associated gene silencing are currently considered to initiate and sustain epigenetic change. New and ongoing research is continuously uncovering the role of epigenetics in a variety of human disorders and fatal diseases.

The Evolving Landscape of Epigenetic Research: A Brief History

What began as broad research focused on combining genetics and developmental biology by well-respected scientists including Conrad H. Waddington and Ernst Hadorn during the mid-twentieth century has evolved into the field we currently refer to as epigenetics. The term epigenetics, which was coined by Waddington in 1942, was derived from the Greek word epigenesis which originally described the influence of genetic processes on development. During the 1990s there became a renewed interest in genetic assimilation. This lead to elucidation of the molecular basis of Conrad Waddingtons observations in which environmental stress caused genetic assimilation of certain phenotypic characteristics in Drosophila fruit flies. Since then, research efforts have been focused on unraveling the epigenetic mechanisms related to these types of changes. Currently, DNA methylation is one of the most broadly studied and well-characterized epigenetic modifications dating back to studies done by Griffith and Mahler in 1969 which suggested that DNA methylation may be important in long term memory function. The renewed interest in epigenetics has led to new findings about the relationship between epigenetic changes and a host of disorders including various cancers, mental retardation associated disorders, immune disorders, neuropsychiatric disorders and pediatric disorders.

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Epigenetics: Fundamentals | What is Epigenetics?

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