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Stem Cell Therapy | South Florida Orthopedic Surgery …

Posted: June 9, 2015 at 10:43 am

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Source: Research by Tim Friend and Dan Vergano, USA TODAY By Frank Pompa and Julie Snider, USA TODAY

Although the general public considers stem cell therapy an innovative, cutting-edge treatment, the fact is that this kind of therapy already has a lengthy history. In the past, however, stem cells were difficult and very expensive to obtain. Luckily, the advent of improved equipment and techniques has meant that stem cells can now be acquired through a simple procedure.

Stem cells can be characterized as the bodys repairmen. The most common type is the hematopoietic stem cell (HSC-CD 34+). The old thinking was that the hematopoietic stem cells were not that important. We now know that these are the cells that are the true drivers of tissue regeneration. The good news about these cells is that their numbers do not diminish with age. The other type of stem cell associated with tissue healing is the mesenchymal stem cell (MSC), which usually travels to injured areas of the body via the bloodstream. The mesenchymal stem cell is still a very important stem cell but not as important as it once was. It prepares the area for the other stem cells to do their work.

If the area in question has an insufficient blood supply, this is termed an area of hypoxia, otherwise known as low oxygen content. Hypoxia areas can include the rotator cuff, the joints, meniscus tissue, and other spots with tendon injuries. Typically, these areas are unable to heal properly without help, as the body does not send enough repair cells to the afflicted areas. The inadequate supply of blood in these areas means that the body fails to sense the injury. Fortunately, we are generally able to treat the area, if the injury isnt severe, with platelet-rich plasma. This works by effectively mimicking a blood supply, allowing the platelets to sense the injury and release growth factors, which then prompt the body to send various stem cells to the area.

Stem cells are gathered by aspirating (removing through suction) bone marrow from the back of a patients pelvis. This bloody substance is removed from the patients pelvis with a tiny needle. Since the patient is given a local anesthetic, only minimal discomfort results from the procedure.

In most cases, 2 oz. (60 cc) of bone marrow aspirate is required. The aspirate includes platelets, mesenchymal stem cells, and other kinds of stem cells used in adult stem cell therapy. After aspiration, the bone marrow is placed inside a special container, which in turn is placed into a machine known as a centrifuge. The centrifuge spins the material at a high rate of speed, and this process separates the platelets and stem cells from the remainder of the blood products. It is this concentration of bone marrowcalled BMAC, or bone marrow aspiration concentratethat is reintroduced to the injured area during stem cell therapy.

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Recovery of sensory function by stem cell transplants

Posted: June 9, 2015 at 3:40 am

New research from Uppsala University shows promising progress in the use of stem cells for treatment of spinal cord injury. The results, which are published in the scientific journal Scientific Reports, show that human stem cells that are transplanted to the injured spinal cord contribute to restoration of some sensory functions.

Traffic accidents and severe falls can cause ruptures of nerve fibers that enter/exit the spinal cord. Most commonly, these avulsion injuries affect the innervation of the arm and hand, and lead to paralysis, loss of sensation and cause chronic pain. Surgical interventions can help the patient regain some muscle function, but there is currently no treatment able to restore sensory functions. The reason for this is the emergence of a "barrier" at the junction between the ruptured nerve fibers and the spinal cord which prevents them from growing into the spinal cord and restore lost nerve connections.

In a new study the PhD students Jan Hoeber, Niclas Knig and Carl Trolle, working in Dr.Elena Kozlova's research group transplanted human stem cells to an avulsion injury in mice with the aim to restore a functional route for sensory information from peripheral tissues into the spinal cord.

The results show that the transplanted stem cells act as a "bridge" which allows injured sensory nerve fibers to grow into the spinal cord, rebuild functional nerve connections, and thereby achieve long term restoration of major parts of the lost sensory functions. The transplanted stem cells differentiated to different types of cells with variable level of maturation, specific for the nervous system. No signs of tumor development or any functional abnormalities from the transplants were observed in the study, outcomes which are important in view of potential risks with transplantation of embryonic stem cells.

The results encourage further research on the use of stem cells for treatment of injury and disease in the spinal cord, and may contribute to the development of novel treatment strategies in these disorders.

Explore further: Trigger mechanism for recovery after spinal cord injury revealed

More information: "Human embryonic stem cell-derived progenitors assist functional sensory regeneration after dorsal root avulsion injury." Scientific Reports, 2015.

In a new study, researchers at Karolinska Institutet in Sweden show that the scar tissue formed by stem cells after a spinal cord injury does not impair recovery; in fact, stem cell scarring confines the damage. The findings, ...

A new study has found that transplantation of stem cells from the lining of the spinal cord, called ependymal stem cells, reverses paralysis associated with spinal cord injuries in laboratory tests. The findings show that ...

One of the most common causes of disability in young adults is spinal cord injury. Currently, there is no proven reparative treatment. Hope that neural stem cells (NSCs) might be of benefit to individuals with severe spinal ...

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Global Stem Cells Group, Stem Cell Training and Anti-aging …

Posted: June 8, 2015 at 10:44 pm

MIAMI (PRWEB) June 08, 2015

Global Stem Cells Group and its subsidiary Stem Cell Training, Inc. have announced plans to conduct a hands-on, two day intensive stem cell training course for physicians and qualified medical professionals Sept. 18 -19, 2015. The training course will be led by anti-aging specialist John P. Salerno, M.D. in Midtown Manhattan.

The founder of The Salerno Center, Salerno practices integrative medicine, combining traditional and alternative healing methods. The course will focus on stem cell therapies for a variety of conditions and treatments including anti-aging therapies. Salerno trained in anti-aging medicine and has opened more than 20 anti-aging medical centers worldwide, including 10 in Japan, three in Brazil and two in Korea.

The Adipose and Bone Marrow Stem Cell Training Course was developed for physicians and high-level practitioners to learn the process through an intensive, hands-on training session that arms participants with clinical protocols and state-of-the-art techniques for isolating and re-integrating adipose- and bone marrow-derived stem cells.

The objective of the training is to teach effective regenerative medicine techniques that can be used to treat patients in-office.

Global Stem Cells Groups Stem Cell Training, Inc. courses have been extended to approximately 35 countries, allowing a global community of physicians to learn how to apply these new stem cell technologies. For more information, visit the Stem Cell Training, Inc. website, email info(at)stemcelltraining(dot)net, or call 305-224-1858.

About Global Stem Cells Group:

Global Stem Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products and solutions. Founded in 2012, the company combines dedicated researchers, physician and patient educators and solution providers with the shared goal of meeting the growing worldwide need for leading edge stem cell treatments and solutions.

With a singular focus on this exciting new area of medical research, Global Stem Cells Group and its subsidiaries are uniquely positioned to become global leaders in cellular medicine.

Global Stem Cells Groups corporate mission is to make the promise of stem cell medicine a reality for patients around the world. With each of GSCGs six operating companies focused on a separate research-based mission, the result is a global network of state-of-the-art stem cell treatments.

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prp stem cell hair treatment for rs 3000 per session …

Posted: June 8, 2015 at 2:43 am

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Tag louisville Archives – Advance Stem Cell …

Posted: June 7, 2015 at 4:47 am

Posted on October 31st, 2013 Krystal Deutsch

The University of Louisvilles Suzanne Ildstad is shown with research coordinator Thomas Miller. Ildstad, her company Regenerex, UofL and Novartis recently signed a global licensing pact to develop her facilitating cell therapy that could make

UofL enters licensing agreement to develop stem cell therapy

LOUISVILLE, Ky., Oct. 30, 2013 /PRNewswire-USNewswire/ The University of Louisville today announced that researcher Dr. Suzanne Ildstad, representing Regenerex LLC, has entered into a license and research collaboration agreement with Novartis to provide access to stem cell technology that has the potential to help transplant patients avoid taking anti-rejection medicine for life and could serve as a platform for treatment of other diseases.

(Photo: http://photos.prnewswire.com/prnh/20131030/DC07303)

The University of Louisville and Regenerex LLC announced the research collaboration agreement which will significantly enhance the universitys Institute for Cellular Therapeutics ability to carry out cutting edge research related to the Facilitating Cell, a novel cell discovered by Ildstad, a professor of surgery and director of the institute at UofL as well as CEO of Regenerex. Underpinning this collaboration is an exclusive global licensing and research collaboration agreement between Regenerex and Novartis.

Ildstad published results in a March 2012 Science Translational Medicine demonstrating the efficacy of this process, known as Facilitating Cell Therapy, or FCRx which is currently undergoing Phase II trials. Five of eight kidney transplant patients were able to stop taking about a dozen pills a day to suppress their immune systems. It was the first study of its kind where the donor and recipient did not have to be biologically related and did not have to be immunologically matched.

In a standard kidney transplant, the donor agrees to donate a kidney. In the approach being studied, the individual is asked to donate part of their immune system as well. The process begins about one month before the kidney transplant, when bone marrow stem cells are collected from the blood of the kidney donor using a process called apheresis. The donor cells are then processed, where they are enriched for developing facilitating cells believed to help transplants succeed. During the same time period, the recipient undergoes pre-transplant conditioning, which includes radiation and chemotherapy to suppress the bone marrow so the donors stem cells have more space to grow in the recipients body.

One day after the kidney is transplanted into the recipient, the donor stem cells engraft in the marrow of the recipient and give rise to other specialized blood cells, like immune cells. The goal is to create an environment where two bone marrow systems co-exist and function in one person. Following transplantation, the recipient takes anti-rejection drugs which are decreased over time with the goal to stop a year after the transplant.

In 1998, Ildstad was one of the first recruits to the University of Louisville under the Commonwealths Bucks for Brains initiative, advanced by former Gov. Paul Patton. As the Jewish Hospital Distinguished Chair in Transplantation Research, Ildstad brought a team of 25 families from Philadelphia to join the University of Louisville. In the following years the team has continued to examine the facilitating cell (FCRx) platform technology for the treatment of kidney transplant recipients as well as considering its potential for the treatment of red blood cell disorders, inherited metabolic storage disorders of childhood, and autoimmune disorders.

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Healthy stem cells donated by German man give Kerala girl …

Posted: June 5, 2015 at 7:49 pm

A 16-year-old girl from Kerala has got a new lease of life, thanks to a benevolent gesture from a 55-year-old German man. The teenage girl was suffering from an advanced stage of leukaemia or bone marrow cancer and underwent a transfusion of healthy stem cells donated by the German national.

She surely is lucky: Even though doctors treating her could not find matching stem cells among more than 70,000 donors registered in India, they finally could locate with the help of an international agency the only one donor whose stem cells matched perfectly with those of the girl patient.

"This is perhaps one of the rarest transnational stem cell donation cases in the country. As there was no matching stem cells from among more than 70,000 listed in a registry in India, we sought help from German-based international registry DKMS," Neeraj Sidharthan, head of stem cell transplant unit at Amrita Institute of Medical Sciences and Research Centre here, told IANS.

"We have been told that this person was the only one whose stem cells matched with the girl's," he said.

After receiving the healthy stem cells from the 55-year-old German man, the girl has since been completely cured of the life-threatening ailment.

"She comes to me for routine check-up and she is doing perfectly fine," said Sidharthan.

Recalling the case, Sidharthan said the girl had a relapsed acute myeloid leukaemia and her chances of survival were slim.

"We suggested allogenic stem cell transplantation, or transfer of stem cells from a healthy person, to save the patient. It's easy since the donar stem cells come either from a sibling or parents. However, in this girl's case, it did not happen," said the doctor.

The doctor finally contacted Germany-based international registry DKMS, and as luck would have it, just one perfectly matching donar stem cells were found.

Once the donor was finalised, the girl was admitted to the institute for pre-transplant tests and administeration of chemotherapeutic drugs to prevent side effects, since the stem cells were to come from an international donor of the opposite sex.

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Information on Stem Cell Research: National Institute of …

Posted: June 5, 2015 at 12:42 am

Introduction Stem Cells are unique in that they have the potential to develop into many different cell types in the body, including brain cells, but they also retain the ability to produce more stem cells, a process termed self renewal. There are multiple types of stem cell, such as embryonic stem (ES) cells, induced pluripotent stem (iPS) cells, and adult or somatic stem cells. While various stem cells can share similar properties there are differences as well. For example, ES cells are able to differentiate into any type of cell, whereas adult stem cells are more restricted in their potential. The promise of all stem cells for use in future therapies is exciting, but significant technical hurdles remain that will only be overcome through years of intensive research.

The NINDS supports a diverse array of research on almost all stem cells, from studies of the basic biology of stem cells in the developing and adult mammalian brain to studies focusing on nervous system disorders such as ALS or spinal cord injury. For example, investigators are looking at how ES cells can be used to derive dopamine-producing neurons that might alleviate symptoms in patients with Parkinsons disease or how somatic stem cells can generate myelin producing oligodendrocytes for remyelination following acute and chronic brain injury. Although there is much promise for using stem cells to treat neurological diseases in humans, there is much work to be done before stem cell-based therapies are ready for the clinic.

The NIH Stem Cell Information Web page provides additional information about stem cell research at NIH. Also, see MedlinePlus for more health information regarding stem cells.

To learn more about investigational therapies, including stem cells, one can search the National Institutes of Health (NIH) online clinical trials database, which has information about federally and privately funded clinical research studies on a wide range of diseases and conditions. You can access this database at ClinicalTrials.gov to learn about the location of research studies in need of participants, as well as their purpose and criteria for patient participation. The NIH also maintains a clinical research website that has additional information and can be found here: NIH Clinical Research Trials and You

NINDS Repository The NINDS also supports a repository that offers human induced pluripotent stem cell (iPSC) lines for research on neurological disorders. A list of available cell lines can be found here: Human Induced Pluripotent Stem Cells

NINDS Stem Cell Research on CampusThe Intramural Research Program of NINDS is one of the largest neuroscience research centers in the world. Investigators in the NINDS intramural program conduct research in the basic, translational, and clinical neurosciences. Their specific interests cover a broad range of neuroscience research including stem cell biology. Listings of NINDS intramural researchers by laboratory affiliation and research areas are available online.

NIH Policy and ImplementationThe Director of the NINDS, Dr. Story Landis is the Chair of the NIH Stem Cell Task Force, which was created to enable and accelerate the pace of stem cell research and to seek the advice of scientific leaders in stem cell research. For comprehensive information on NIH policies related to stem cell research, visit the NIH Stem Cell Information web page.

NIH Center for Regenerative Medicine (NIH CRM)NIH CRM is a community resource that works to provide the infrastructure to support and accelerate the clinical translation of stem cell-based technologies, and to develop widely available resources to be used as standards in stem cell research. The Center provides services and information to both the intramural and extramural NIH communities that facilitate the use of stem cell technologies for therapeutic purposes and for screening efforts. Further information about NIH CRM can be found here: NIH Center for Regenerative Medicine

Funding OpportunitiesNINDS supports a wide array of stem cell research, both basic and disease-related. Funding mechanisms supported by NINDS can be found here: Funding Mechanisms

Additionally, those interested in targeted funding solicitations can search the NIH Guide for Grants and Contracts. One can do key word searches for entries such as neurological disease and stem cell or regenerative medicine. A link to the NIH Guide can be found here: NIH Guide for Grants and Contracts

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Adimarket Named Latin American Distributor for Bioquark …

Posted: June 4, 2015 at 10:45 pm

Adimarket, a Global Stem Cells Group subsidiary, has been named distributor in Latin America for Bioquark Biologic regenerative medicine products, developed for tissue and organ repair and regeneration.

MIAMI (PRWEB) June 02, 2015

Global Stem Cells Group subsidiary Adimarket has been named the Latin America distributor for Bioquark, Inc.s biologic products for the regeneration and repair of human organs and tissues. The announcement is the latest in Global Stem Cells Groups ambitious expansion plans in Latin America, a commitment made to meet the regions growing demand for access to regenerative medicine and stem cell therapies.

Bioquark Inc. is focused on the development of biologics that have the ability to alter the regulatory state of human tissues and organs, with the goal of curing a range of chronic diseases, as well as affecting complex tissue regeneration. The biologic regulatory states of human cells, tissues and organs represent the central control processes behind disease, degeneration and aging.

Bioquarks core program focuses on developing a singular class of substances, termed combinatorial biologics, which take a different approach to reversing underlying disease, degeneration or aging processes, as opposed to only effecting only the symptoms of these conditions.

Combinatorial biologics work at the level of the regulatory genome and are modeled off of biochemical dynamics found in various species that can naturally modify biologic regulatory states to achieve beneficial outcomes, such as complex tissue and organ regeneration, disease reversion, and even biological age reversal.

The revolutionary work that Bioquark is performing is a perfect fit for Global Stem Cells Groups vision of the potential that stem cell therapies hold, now and in the future, says Ricardo DeCubas, Global Stem Cells Group co-founder and Regenestem CEO.

The collaboration between Global Stem Cells Group, Adimarket and Bioquark is another step toward GSCGs commitment to expanding its presence in communities that need and deserve access to cutting-edge regenerative medicine, not only in Latin America but also worldwide.

For more information visit the Global Stem Cells Group website, email bnovas@stemcellsgroup.com, or call 305-224-1858.

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Global Stem Cells Group and Marina Medical Announce …

Posted: June 4, 2015 at 10:43 pm

Global Stem Cells Group and Marina Medical, Inc. announce plans to conduct joint stem cell training courses worldwide. GSCG subsidiary Adimarket will distribute stem cell products to Latin America in conjunction with the joint training program.

MIAMI (PRWEB) June 04, 2015

MIAMI, June 4, 2015Global Stem Cells Group and Marina Medical, Inc. have announced plans to conduct joint stem cell training courses for physicians and qualified medical professionals worldwide. Sunrise, Florida-based Marina Medical is an established leader in design, manufacture and distribution of medical devices for OBGYN, plastic and aesthetic surgery, regenerative medicine and urogynecology.

Marina Medicals recently launched Koume Cannalus division manufactures instruments for regenerative medicine procedures. Teaming with GSCG for the stem cell training courses will help to further stem cell education among those medical professionals who use Marina Medical instruments.

Global Stem Cells Group subsidiary Adimarket will provide regenerative medicine equipment and supplies for the joint training session held in Latin America.

The Adipose and Bone Marrow Stem Cell Training Course was developed for physicians and high-level practitioners to learn the process of isolating and re-integrating adipose- and bone marrow-derived stem cells through an intensive, hands-on training session. The objective is to arm participating physicians with clinical protocols and state-of-the-art techniques so that they can bring regenerative medicine therapies to their patients in-office.

Global Stem Cells Groups Stem Cell Training, Inc. courses have been extended to approximately 35 countries, allowing a global community of physicians to learn how to apply these new stem cell technologies. For more information, visit the Global Stem Cells Group website, email bnovas(at)stemcellsgroup(dot)com, or call 305-224-1858.

About Global Stem Cells Group:

Global Stem Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products and solutions. Founded in 2012, the company combines dedicated researchers, physician and patient educators and solution providers with the shared goal of meeting the growing worldwide need for leading edge stem cell treatments and solutions.

With a singular focus on this exciting new area of medical research, Global Stem Cells Group and its subsidiaries are uniquely positioned to become global leaders in cellular medicine. Global Stem Cells Groups corporate mission is to make the promise of stem cell medicine a reality for patients around the world. Each of GSCGs six operating companies focus on a separate research-based mission; the result is a global network of state-of-the-art stem cell treatments and facilities.

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Stem Cells: Thematic Research Areas

Posted: June 4, 2015 at 10:43 pm

Information on this page is excerpted from the UConn Health Stem Cell website.

Responding to the federal restrictions on the creation of new stem cell lines for research, the Connecticut General Assembly passed legislation that was signed into law by then Gov. M. Jodi Rell, authorizing the use of public funds to finance human stem cell research. The law commits $100 million over a period from 2007 to 2017 to support this highly promising area of bioscience research.

While five states have passed similar legislation, Connecticut, has set a new standard by becoming the first state to actually implement a structured, ongoing research grant program of this type. The law established a competitive process for awarding research grants. An impartial Stem Cell Research Advisory Committee, chaired by the Connecticut Commissioner of Public Health, was appointed to distribute the funds based on the scientific, legal and ethical integrity of the research being done.

Fifteen of the 21 research proposals funded were awarded to UConn faculty. Collectively, they amounted to nearly $12 million, or about 60 percent of the total disbursal. The funding supports investigators engaged in a wide range of research projects designed to unlock the secrets of stem cells and turn them into effective treatments for a host of diseases and disorders as quickly as possible.

Below is a listing of UConn Health faculty who received State of Connecticut Stem Cell Awards along with a brief description of their research projects.

Hector Leonardo Aguila

FACS isolation of progenitors and generation novel cell surfaces antibodies.

In order for researchers to use stem cells for regenerative therapies, the design of methods for the correct identification of stem cells is crucial. One of the best approaches not only to characterize different cell types, but also to isolate them - is the generation of antibodies against cell surface molecules. The Project 2 group has developed unique tracking systems for musculoskeletal development to visualize progenitor cells with the ability to develop into cartilage, bone, fat and muscle. These systems employ genetic techniques that add genetic information to embryonic stem cells to make them express fluorescent protein at defined stages of their development.

Gordon G. Carmichael and Asis Das

DsRNA and epigenetic regulation in embryonic stem cells.

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