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UW-Madison Heart Stem Cell Study Among American Heart …

Posted: May 28, 2015 at 1:44 pm

Madison, Wisconsin - In 2009, a group of cardiovascular researchers at the University of Wisconsin School of Medicine and Public Health proved that functional human heart muscle cells can be produced from genetically reprogrammed skin cells.

According to the American Heart Association (AHA), the discovery was one of the10 most important research advances for cardiovascular disease and stroke for the year.

Timothy Kamp, MD, PhD, FACC,a UW professor of medicine, in collaboration with stem cell pioneer James Thomson, DVM, PhD,led the team that demonstrated that human induced pluripotent stem (IPS) cells could be differentiated into contracting cardiac cells. The team's findings raise the possibility that a patient's own skin cells could someday be used to repair damaged heart tissue.

"It's certainly an honor to have our research recognized by an organization devoted to the same goal we are-keeping patients' hearts healthy," says Dr. Kamp. "Much more research is needed before this type of stem cell can be used clinically, but there is significant promise that these cells may provide a powerful new treatment for heart failure and other degenerative diseases of the heart."

The AmericanHeart Associationdoesn't assign rank to the research advances on its annual list. Other notable advances included studies documenting the effectiveness of controlling calories in maintaining heart health, the effectiveness of oral blood thinners in patients with stroke and atrial fibrillation and the impact of smoke-free legislation on reducing heart attacks.

Date Published: 01/22/2010

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Marx Biotechnology A disruptive technology that saves …

Posted: May 27, 2015 at 4:47 am

A disruptive technology that saves lives and improves patient care Main menu Marx Biotechnology is developing a proprietary first-in-class molecular diagnostic kit for the early detection of Graft versus Host Disease (GVHD). GVHD is a life threatening complication of allogeneic (non-self) stem cell transplantation such as bone marrow, peripheral blood or cord blood transplantation

and solid organ transplantations. The cells from the donor react

adversely to the cells in the patient. GVHD affects approximately 50% of all such transplant patients, frequently resulting in death. https://www.youtube.com/watch?v=c_8PcfZSkrI Marx Bios approach has 5 clear advantages:

Incorporated in Jerusalem in January 2011, the Marx Bio team has completed proof of concept in animal studies, has published in a peer reviewed journal, and has filed three patents. It is commencing a Phase 1 clinical trial in humans in Tel Aviv.

Marx Bio has a clear work schedule to deliver a validated and cleared product, ready for market entry within 36 to 48 months. The company is looking for strategic partners to join in that journey.

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Roles of Amacrine Cells by Helga Kolb Webvision

Posted: May 25, 2015 at 6:45 am

Helga Kolb

1. General characteristics.

Amacrine cells of the vertebrate retina are interneurons that interact at the second synaptic level of the vertically direct pathways consisting of the photoreceptor-bipolar-ganglion cell chain. They are synaptically active in the inner plexiform layer (IPL) and serve to integrate, modulate and interpose a temporal domain to the visual message presented to the ganglion cell. Amacrine cells are so named because they are nerve cells thought to lack an axon (Cajal, 1892). Today we know that certain large field amacrine cells of the vertebrate retina can have long axon-like processes which probably function as true axons in the sense that they are output fibers of the cell (see later section on dopaminergic amacrine cells). However these amacrine axons remain within the retina and do not leave the retina in the optic nerve as do the ganglion cell axons. Figure 1 shows one of the earliest depictions of the retinal cell types including amacrine cells drawn by Ramon y Cajal (circa 1890). These retinal cell types were visualized using the anatomical silver impregnation method devised by the Italian anatomist Camillo Golgi in the nineteenth century (Fig. 2).

Fig. 1. Drawing of the retina made by Cajal

Since the time of Cajal we have known that amacrine cells come in all shapes, sizes and stratification patterns. Since those days many more morphological subtypes have and continue to be described from further Golgi studies, intracellular recordings and immunocytochemical staining. Thus, we presently have a classification of amacrine cells consisting of about 40 different morphological subtypes.

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Foundation Volume 3, Chapter 55. Molecular Genetic Basis …

Posted: May 23, 2015 at 11:47 pm

1. Rommens JR, Iannuzzi MC, Kerem BS et al: Identification of the cystic fibrosis gene: chromosomal walking and jumping. Science 245:1059, 1989

2. Hall JM, Friedman L, Guenther C et al: Closing in on a breast cancer gene on chromosome 17q. Am J Hum Genet 50:1235, 1992

3. Easton DF, Bishop DT, Ford D et al: The Breast Cancer Linkage Consortium: Genetic linkage analysis in a familial breast and ovarian cancer: results from 214 families. Am J Hum Genet 52:678, 1993

4. Fishel R, Loscoe MK, Rao MRS et al: The human mutator gene homolog MSH2 and its association with hereditary polyposis colon cancer. Cell 75:1027, 1993

5. The Huntington's Disease Collaborative Research Group: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72:971, 1993

6. Saunders AM, Strittmatter WJ, Schmechel D et al: Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43:1467, 1993

7. Frezal J, Abule MS, De Fougerolle T: Gene atlas: A catalogue of mapped genes and other markers, 2nd ed, p 1013. Paris, Inserm/John Libbey, 1991

8. Frezal J, Kaplan J, Dolifus H: Mapping the eye diseases. Ophthalmic Paediatr Genet 13:37, 1992

9. Musarella MA: Gene mapping of ocular diseases. Surv Ophthalmol 36:285, 1992

10. Jay B, Jay M: Molecular genetics in clinical ophthalmology. In Davidson SI, Jany B (eds): Recent Advances in Ophthalmology, Vol 8, pp 185206. New York, Churchill Livingstone, 1992

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TOLweb: what is phylogeny? – Tree of Life Web Project

Posted: May 23, 2015 at 11:47 pm

Biologists estimate that there are about 5 to 100 million species of organisms living on Earth today. Evidence from morphological, biochemical, and gene sequence data suggests that all organisms on Earth are genetically related, and the genealogical relationships of living things can be represented by a vast evolutionary tree, the Tree of Life. The Tree of Life then represents the phylogeny of organisms, i. e., the history of organismal lineages as they change through time. It implies that different species arise from previous forms via descent, and that all organisms, from the smallest microbe to the largest plants and vertebrates, are connected by the passage of genes along the branches of the phylogenetic tree that links all of Life (Figure 1).

Figure 1: All organisms are connected by the passage of genes along the branches of the phylogenetic Tree of Life.

The organisms that are alive today are but the leaves of this giant tree, and if we could trace their history back down the branches of the Tree of Life, we would encounter their ancestors, which lived thousands or millions or hundreds of millions of years ago (Figure 2).

Figure 2: Living organisms sit like leaves at the tips of the branches of the Tree of Life. Their evolutionary history is represented by a series of ancestors which are shared hierarchically by different subsets of the organisms that are alive today.

The notion that all of life is genetically connected via a vast phylogenetic tree is one of the most romantic notions to come out of science. How wonderful to think of the common ancestor of humans and beetles. This organism most likely was some kind of a worm. At some point this ancestral worm species divided into two separate worm species, which then divided again and again, each division (or speciation) resulting in new, independently evolving lineages. Little did these worms know, those hundreds of million years ago, that some of their number would end up evolving into beetles, while their brothers and sisters would end up as humans or giraffes.

Organisms have evolved through the ages from ancestral forms into more derived forms. New lineages generally retain many of their ancestral features, which are then gradually modified and supplemented with novel traits that help them to better adjust to the environment they live in. Studying the phylogeny of organisms can help us explain similarities and differences among plants, animals, and microorganisms. The Tree of Life thus provides a rigorous framework to guide research in all biological subdisciplines, and it is therefore an ideal model for the organization of biological knowledge.

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What Is Stem Cell Research? (with pictures) – wiseGEEK

Posted: May 23, 2015 at 11:46 pm

anon950526 Post 156

Is there any impact due to this?

Obviously, some of you dont have kids. The life of a child is worth so much more than any adult. You got to live. What if that embryo happened to be you? Would you then feel that it is OK to conduct this research?

I am a mother of two, soon to be three. I don't care about any of that just long as my kids at least get a chance at living and there is a God. I had a 50 percent chance of having babies because of a huge benign tumor that grew on my left ovary and killed my left fallopian tube.

I prayed for my babies and got them every time. Besides that, everybody has their

I watched this gruesome abortion video and the lady was 12 weeks along. You could see the child trying to fight for its life. Murder is murder. Helping to save other people or not -- that's like you seeing a man trying to rape a woman and you shoot him dead. It's the same if you were trying to save her life but you get persecuted and convicted for taking matters into your own hands. I am sorry for those people who are sick and have sick babies. I know what it is like to lose loved ones over untreatable diseases. Im against embryo research and I'm not thinking about me. It is about a baby. Sure, it isnt completely formed, but it's still a child, or at least will grow into one, I wish harm on nobody. There is no harm meant and Im not trying to make someone mad. Im just trying to throw some new views into the situation.

Stem cell research can only benefit society and advance us as a species. If your argument is religious, the you are not thinking. You are letting your emotions and beliefs speak for you, not your logic or common sense. A bunch of cells is not a baby, and helping the living is not against "God's will". This is a good thing and it will continue regardless of religious views, because it makes sense.

I'm still kind of learning about this topic, but abortion is something I feel strongly against, but if a baby was taken from it's mother with the mother's okay and they were trying to save people's lives, I would be completely okay with that.

I believe that God does not exist, and that stem cell research is truly phenomenal. This research should not be controversial, nor should it be banned; it is helping the living.

Most of the people who say that stem cell research is bad are religious, but people living in the real world and believe in this thing called 'science' actually make a difference. Religion has only held back society and science. I wonder how many religious people would get angry if they knew that I was a homosexual, atheist physicist who believes in evolution and the big bang theory.

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Stem Cell Treatment Stem Cell Therapy Stem Cell Research

Posted: May 23, 2015 at 11:46 pm

Stem Cell Therapy

Stem cell treatment and stem cell therapy may be considered controversial and are, perhaps, viewed as akin to science fiction by some people. However, stem cell treatments have been used regularly in veterinary practice since 2003 for the repair of bone and tissue damage, and have a wealth of research highlighting their efficacy in both humans and other animals. Stem cells are found in plentiful supply in embryonic tissue, but are also found in adult tissues. These cells have the ability to self-renew, giving rise to countless generations of new cells with varying abilities to differentiate into specific cell types. By introducing stem cells into an area of damage or pathology, the body can be encouraged to repair and renew regardless of how old the trauma is. Stem cells also show application for inhibiting the death of cells (apoptosis) through disease, making them candidates for use in treating degenerative illnesses such as Lou Gehrigs disease, Multiple Sclerosis, Parkinsons disease and Alzheimers.

Stem cells from embryos are considered more flexible in terms of their ability to become either new liver cells, new neurons, new skin cells, and so on, whereas adult stem cells tend to be more restricted to the tissue type from which they were taken. New research is showing that this might not necessarily have to remain the case however, with the plasticity of adult stem cells now under investigation. Stem cell use carries little risk of the resulting tissues being rejected, it appears safe, efficient, and almost endless in its possibilities for application.

Potential Stem Cell Treatments

Conditions such as cardiovascular disease, diabetes, spinal cord injury, and cancer, among others, are considered possible candidates for stem cell treatment. Cures for some of these diseases could be closer than previously thought with clinical trials already showing impressive results where stem cells have been used in cases thought intractable. The rapid rate of progression in research and clinical use means that some of the controversial issues, such as the use of embryos as a source of stem cells, have been overcome, with governments around the globe subtly altering their legal policies in order to accommodate new scientific advances. In the US, Bill Clinton was the first president to have to consider the legal issues surrounding stem cells, and subsequent presidents have been forced to readdress the issues time and again in line with medical discoveries. Worldwide, governments have remained generally cautious over the use of this technology but are gradually improving funding access, whilst keeping an eye on the ethics of stem cell treatment, in order to explore the tremendous benefits that appear possible. The credibility of research remains a concern, with some stem cell studies discredited by ethics committees after initial general acceptance of their veracity.

Stem cells may be garnered from living adult donors and, indeed, already are in the case of bone marrow transplants. More usually they are taken from discarded embryos leftover after IVF treatment, or from the placenta after birth. Previously the removal of stem cells resulted in the destruction of these embryos, but now it is possible for scientists to remove the stem cells without this occurring. This development negates some of the criticism faced by the technology from religious groups and ethical bodies over the sanctity of life and the attribution of sentience and autonomy to embryos, gametes, and the foetus. Clearly, some debate remains about these issues in relation to stem cell research, but recent improvements in methodology may remove the need for these considerations completely. Clinicians have demonstrated the possibility of taking adult stem cells and seemingly teaching them to become cells of a different type to their site of removal, effectively returning them to a similar state to that of the embryonic stem cell. Whilst stem cells from embryos remain more reliable and more economical to work with, the use of adult tissue-derived stem cells could revolutionize the research in this field.

As well as stem cell use in pathology and disease, there are also applications in personal aesthetics such as the regeneration of hair follicles and an end to baldness through stem cell treatment. Stem cells are also considered useful in regenerating the skin after injury, without the scarring usually associated with repair. There are reports of paralyzed patients becoming mobile after years in a wheelchair through the use of stem cells injected into the spinal cord, and the rapid disappearance of tumors in brain tissue after stem cells were injected.

Stem cell treatment provides an exciting possibility to change the face of modern medicine, alleviating pain and suffering, and improving the prognosis for millions withe diseases previously thought incurable.

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Stritch School of Medicine Department of Preventive …

Posted: May 23, 2015 at 8:42 am

Public Health Sciences is an academic department within Loyola Stritch School of Medicine. While the discipline of public health has traditionally been disconnected from clinical medicine it is now widely accepted that to meet the challenges of the 21st century we must create a health system where research, education and patient care function as a fully integrated whole. To achieve this goal we envision an array of multi-disciplinary programs that are capable of monitoring health trends and identifying disease-causing agents, assessing the medical care needs of populations, providing high quality preventive and curative treatment for everyone in our society, and measuring the outcomes of these interventions in the population and for individual patients. Reaching this goal is a formidable challenge for the United States, given our historically limited investment in public health, the fragmented system of health care currently in place, and our weak capacity to monitor quality and outcomes.

The Loyola Department of Public Health Sciences seeks to play a role in helping us reach this goal of a universal, integrated health system through research and teaching. In particular, we believe the need to address health inequalities among racial, ethnic and other marginalized populations is the most urgent challenge the US health system faces. Since its inception the Departments research and service has been largely focused on that challenge. Health inequalities do not stop at national borders and our Department also has a long tradition of global health research and education in public health.

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Cell Isolation Products, Cell Culture Media, Cell Research

Posted: May 23, 2015 at 12:40 am

Product Type Please Select Specialized cell culture media Cell isolation products Antibodies Primary cells Mammalian cloning products Small molecules Contract services Cryopreservation media Cytokines Cell culture substrates and matrices Other cell culture media, reagents & supplies Instruments Software Stem cell detection kits Training & education Proficiency testing T-shirts

Cell Type Please Select B cells Brain tumor stem cells Bronchial epithelial cells CHO cells Dendritic cells Embryonic stem cells & iPS cells (Human) Embryonic stem cells & iPS cells (Mouse) Granulocytes & subsets Hematopoietic stem & progenitor cells Hybridomas Lymphocytes Mammary epithelial cells Mesenchymal stem cells Monocytes Myeloid cells Neural stem & progenitor cells Neurons Natural killer (NK) cells Other cells Prostate epithelial cells Regulatory T cells T cells

Area of Interest Please Select Cancer Cell line development Chimerism analysis Cord blood banking Embryonic stem cell & induced pluripotent stem cell research Endothelial & angiogenic cell research Hematologic malignancies Hematopoietic stem cell research HIV HLA Hybridoma generation Immunology Immunology (Mouse) Intestinal research Mammary cell research Mesenchymal stem cell research Neuroscience Pharmacology, toxicology & drug discovery Prostate cell research Respiratory research Semi-solid cloning Stem cell biology

Popular Product Lines Please Select AggreWell ALDECOUNT ALDEFLUOR CFU-Hill Medium ClonaCell CollagenCult EasySep EpiCult EPO-ELISA ES-Cult IntestiCult MammoCult MegaCult MesenCult MethoCult mTeSR1 and Family MyeloCult NeuroCult PneumaCult Primary cells ProstaCult RoboSep RosetteSep SepMate STEMdiff StemSep StemSpan STEMvision

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Stem Cell Therapy for Arthritis and Injuries | Regenexx

Posted: May 23, 2015 at 12:40 am

Welcome to Regenexx Stem Cell Therapy for Arthritis & InjuriesChris Centeno2015-05-11T15:25:31+00:00

The Regenexx Procedures are the nations most advanced non-surgical stem cell and blood platelet treatments for common injuries and degenerative joint conditions, such as osteoarthritis and avascular necrosis. These stem cell procedures utilize a patients own stem cells or blood platelets to help heal damaged tissues, tendons, ligaments, cartilage, spinal disc, or bone.

The list below represents the most commonly treated conditions using Regenexx stem cell or platelet procedures. It is not a complete list, so please contact us or complete the Regenexx Candidate Form if you have questions about whether you or your condition can be treated with these non-surgical procedures. The type of procedure used (stem cell or blood platelet) to treat these conditions is largely dependent upon the severity of the injury or condition.

0

AND COUNTINGMORE THAN 16,000 REGENEXX PROCEDURES HAVE BEEN PERFORMED AS OF FEBRUARY 2015 (SINCE 2005)

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THE PUBLISHED RESEARCH ON REGENEXX PROCEDURES ACCOUNTS FOR APPROX. 30% OF THE WORLDS ORTHOPEDIC STEM CELL LITERATURE (cumulative n of patients published and treated with bone marrow stem cells)

Regenexx and the Centeno-Schultz Clinic is theoriginalstem cell based musculoskeletal practice in the United States, with more stem cell orthopedics experience than any other clinic. Regenexx and the Regenexx Network are physician leaders in stem cell treatments for osteoarthritis, joint injuries and spine conditions, in terms of research presentations, publications, and academic achievements.

As our Regenexx Physician Network grows, so does the nationwide awareness of our next-generation regenerative procedures. This video selection is comprised of recent local news stories, media coverage and hit television show appearances, featuring Regenexx doctors and patients from around the network, sharing their stories. For more Regenexx videos, please visit our videos page or YouTube Channel.

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