Posted: March 28, 2015 at 11:47 pm
Jeunesse Global Finiti
FINITI contains the only proprietary blend of natural ingredients known to safely lengthen short telomeres and maintain healthy stem cells. It also protects your DNA, telomeres, and cells...
By: FM CLUB
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Jeunesse Global Finiti - Video
Posted: March 28, 2015 at 11:47 pm
What is regenerative medicine
Siddharth Tambar MD discusses regenerative medicine treatments for arthritis and tendinitis, including prp and stem cells.
By: Chicago Arthritis
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What is regenerative medicine - Video
Posted: March 28, 2015 at 11:47 pm
AALLFRED STEM CELL RESEARCH Alex Sandoval
Finding cure and protecting life.
By: Alex Sandoval
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AALLFRED STEM CELL RESEARCH Alex Sandoval - Video
Posted: March 27, 2015 at 9:41 pm
EVEN without surgery, one can now experience a dramatic improvement and even cure on health concerns such as diabetes, cancer, HIV, and cardiovascular diseases. This is through the stem cell technology and telomere science.
Dr. Marc Lavaro Jr., an expert on general & ocular oncology, general & ocular pharmacology, pediatric ophthalmic medicine, and Science of Epigenetics said these new technology are considered as breakthrough which repairs and rejuvenates the cells.
Lavaro, head of a molecular biology research in Gifu Prefecture, Japan and Osato Research Institute, Tokyo Japan stressed that stem cell is a kind of cell that can duplicate all kinds of cell which is why it can repair a damaged heart for instance.
In his book entitled 278+ Growth Factors which he is set to publish, he also mentioned that there are also certain organs which do not regenerate like the heart and brain but through stem cells it can revitalize.
Growth factors are stem cell stimulators that address medical conditions including diseases. Each growth factor is equivalent to 1 disease. For example, in a tumor kidney problem, stem cells produce growth factors to combat it.
Another technology is the telomere science under science of Epigenetics. Telomere is part of the chromosome and it protects it. It is responsible for the cell division and daily produces new cell to replace the dead cells.
Ang cell natin is designed to last forever but and pag-ikli ng telomere ang cause of sickness. Pero pwede na siyang marepair. Activator enzyme siya kaya reverse telomere rejuvenate cell, Lavaro explained.
The good news is the stem technology is now in the market and it comes in the form of liquid gel, capsule, and syrup. This is produced by Jeunesse , an exclusive patent pending stem cell technology advance technology, science of epigenetics, and stem cell science technology. It is also cheaper compared to the old stem technology wherein one has to pay for at least 700,000 to more than one million pesos per shot.
Jeunesse is a product of medical research conducted by Dr. Nathan Newman, the father of stem cell technology and world renowned for his cosmetic surgery and innovator of stem cell lift cutting edge cosmetic surgery, without cutting.
Dapat conscious tayo sa health natin at alamin ang tinatake natin if nagwowork talaga o hype lamang ng company, Lavaro added.
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Sungduan: Growth factors
Posted: March 27, 2015 at 5:56 pm
Imaging tests like mammograms or CT scans can detect tumors, but figuring out whether a growth is or isn't cancer usually requires a biopsy to study cells directly. Now results of a Johns Hopkins study suggest that MRI could one day make biopsies more effective or even replace them altogether by noninvasively detecting telltale sugar molecules shed by the outer membranes of cancerous cells.
The MRI technique, so far tested only in test tube-grown cells and mice, is described in a report published March 27 in the online journal Nature Communications.
"We think this is the first time scientists have found a use in imaging cellular slime," says Jeff Bulte, Ph.D., a professor of radiology and radiological science in the Institute for Cell Engineering at the Johns Hopkins University School of Medicine. "As cells become cancerous, some proteins on their outer membranes shed sugar molecules and become less slimy, perhaps because they're crowded closer together. If we tune the MRI to detect sugars attached to a particular protein, we can see the difference between normal and cancerous cells."
Bulte's research builds on recent findings by others that indicate glucose can be detected by a fine-tuned MRI technique based on the unique way it interacts with surrounding water molecules without administering dyes. Other researchers have used MRI but needed injectable dyes to image proteins on the outside of cells that lost their sugar. In this study, Bulte's research team compared MRI readings from proteins known as mucins with and without sugars attached to see how the signal changed. They then looked for that signal in four types of lab-grown cancer cells and detected markedly lower levels of mucin-attached sugars than in normal cells.
Xiaolei Song, Ph.D., the lead author on the study and a research associate in Bulte's laboratory, explains that this is the first time a property integral to cancer cells, rather than an injected dye, has been used to detect those cells. "The advantage of detecting a molecule already inside the body is that we can potentially image the entire tumor," she says. "This often isn't possible with injected dyes because they only reach part of the tumor. Plus, the dyes are expensive."
Bulte cautions that much more testing is needed to show that the technique has value in human cancer diagnosis. His team's next step will be to see if it can distinguish more types of cancerous tumors from benign masses in live mice.
If further testing does show such success, Bulte and Song suggest the technique could be used to detect cancer at an early stage, monitor response to chemotherapy, guide biopsies to ensure sampling of the most malignant part of a tumor and eventually make at least some biopsies unnecessary.
Other authors on the paper are Raag D. Airan, Dian R. Arifin, Amnon Bar-Shir, Deepak K. Kadayakkara, Guanshu Liu, Assaf A. Gilad, Peter C.M. van Zijl and Michael T. McMahon, all of The Johns Hopkins University.
This project was supported by the National Institute of Biomedical Imaging and Bioengineering (grant numbers R01 EB015032 and R01 EB015031), the National Cancer Institute (grant number U54 CA151838), the Maryland Stem Cell Research Foundation (grant number MSCRFII-0042), and the Pearl and Yueh-Heng Yang Foundation.
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MRI based on a sugar molecule can tell cancerous from noncancerous cells
Posted: March 27, 2015 at 5:54 pm
REGENERATIVE MEDICAL SOLUTIONS is a subsidiary of LAB DOM (SUISSE) INC.
Anti-Aging, Regeneration and Longevity are emergent fields in spa, vacation and leisure care, cosmetics and beauty services. Our team has alchemized a series of techniques, trainings, tools and products that are turn-key trend generators.
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Stem Cells Thailand - Stem Cell Therapy Thailand
Posted: March 27, 2015 at 5:54 pm
Dr. Marc Darrow Stem Cell Therapy
There is so much research centered on stem cell therapy for osteoarthritis because doctors have long known that fixing diseased or damaged articular cartilage in patients is still a challenge despite advances in surgery and MRI diagnosis. This is why mesenchymal stem cells (mesenchymal stem cells that create soft tissue ) are being studied for their regenerative properties and why research like that above is so exciting . In related research not only did injected stem cells begin the healing process, but they also mobilized the native stem cells in the knee to start repairing damage the healing environment of the whole joint was swicthed on.
Traditional treatments for the patient / athlete with osteoarthritis are designed to reduce pain and symptoms. They are not designed to rebuild the natural joint.This is why many of the treatments fail the patients expectations. NSAIDs, nonsteroidal anti-inflammatory drugs and/or surgical treatments may only temporary relief if not further complication and weakening as outlined in many articles on this blog.
In our practicewe specialize in treatments that rebuild, rejuvenate, and strengthen joints effected by osteoarthritis.Not only do Mesenchymal stem cells (MSCs) have the potential to stop the degenerative process of Osteoarthritis theyhave the ability to rebuild articular cartilage, tendons, ligaments, and other soft tissue.
With an aging population, the prevalence of osteoarthritis has increased.Mesenchymal Stem Cells (MSCs) have been proposed to be an attractive alternative candidate in the tissue engineering of articular cartilageprimarily due to its abundant source, reduced cartilage donor site morbidity, and strong capacity for proliferation and potential to differentiate toward a chondrogenic phenotype (make cartilage). 1
Adult stem cells are extracted from the patients own body and used to create a healing solution containing platelet-rich plasma and stem cells. This is done in accordance with FDA guidelines that prohibit manipulation of the stem cells. Once injected into degenerated joints and ligaments, your own newly activated stem cells go to work causing a dynamic self-repair response on the cellular level.
Adult Stem Cell Therapy has the potential to provide joint, tendon, ligament, and muscle regeneration, and is the next frontier for Prolotherapy and PRP.Treat painful back and joint problems with Adult Stem Cell Therapy. Learn more today!
1. Tang QO, Carasco CF, Gamie Z, Korres N, Mantalaris A, Tsiridis E. Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering. Expert Opin Biol Ther. 2012 Oct;12(10):1361-82. Epub 2012 Jul 12. 2.
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Stem Cell Institute Los Angeles Chronic Pain Treatments
Posted: March 27, 2015 at 5:52 pm
A promising new treatment for breast cancer being developed at Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine (VIMM) has been shown in cell culture and in animal models to selectively kill cancer stem cells at the original tumor site and in distant metastases with no toxic effects on healthy cells, including normal stem cells. Cancer stem cells are critical to a cancers ability to recur following conventional chemotherapies and radiation therapy because they can quickly multiply and establish new tumors that are often therapy resistant.
The study, published in the International Journal of Cancer, focuses on a gene originally cloned in the laboratory of primary investigator Paul B. Fisher, M.Ph., Ph.D. The gene, melanoma differentiation associated gene-7 (mda-7), also known as interleukin (IL)-24, has been shown to directly impact two forms of cell suicide known as apoptosis and toxic autophagy, regulate the development of new blood vessels and also play a role in promoting cancer cell destruction by the immune system. In the present study, the researchers used a recombinant adenovirus vector, an engineered virus with modified genetic material, known as Ad.mda-7 to deliver the mda-7/IL-24 gene with its encoded protein directly to the tumor.
Therapy with the mda-7/IL-24 gene has been shown to be safe in a phase I clinical trial involving patients with advanced cancers, and prior studies in my laboratory and with collaborators have shown that the gene could also be effective against breast, prostate, lung, colorectal, ovarian, pancreatic and brain cancers, says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics program at VCU Massey, chairman of VCU School of Medicines Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine (VIMM). Our study demonstrates that this therapy may someday be an effective way to eradicate both early and advanced stage breast cancer, and could even be used to reduce the risk of cancer recurrence.
The researchers found that infection of human breast cancer cells with the adenovirus decreased the proliferation of breast cancer stem cells without affecting normal breast stem cells. It was also shown to induce a stress response in the cells that led to apoptosis by disrupting Wnt/B-catenin signaling, a process cells rely upon to transmit signals that initiate biological functions critical to survival. In mouse models, the therapy profoundly inhibited the growth of tumors generated from breast cancer stem cells and also killed cancer cells in distant, uninjected tumors.
Since discovering the mda-7/IL-24 gene, Fisher and his team have worked to develop better ways to deliver it to cancer cells, including two cancer terminator viruses known as Ad.5-CTV and Ad.5/3-CTV. Cancer terminator viruses are unique because they are designed to replicate only within cancer cells while delivering immune-modulating and toxic genes such as MDA-7/IL-24. Coupled with a novel stealth delivery technique known as ultrasound-targeted microbubble destruction (UTMD), researchers can now systemically deliver viruses and therapeutic genes and proteins directly to tumors and their surrounding tissue (microenvironment) at both primary and metastatic tumor sites. UTMD uses microscopic, gas-filled bubbles that can be paired with viral therapies, therapeutic genes and proteins, and imaging agents and can then be released in a site and target-specific manner via ultrasound. Fisher and his colleagues are pioneering this approach and have already reported success in experiments utilizing UTMD technology and mda-7/IL-24 gene therapy in prostate and colorectal cancer models.
We are hopeful that this targeted gene therapy could be safely combined with conventional chemotherapies to significantly improve outcomes for patients with breast cancer and potentially a variety of other cancers, says Fisher. When paired with promising new delivery techniques such as UTMD, physicians may one day be able to better target site-specific cancers and also monitor the effectiveness of these types of therapies in real time.
Fisher collaborated on this study with Paul Dent, Ph.D., member of the Developmental Therapeutics program at VCU Massey, professor in the Department of Neurosurgery at VCU School of Medicine and member of VIMM; Xiang-Yang Wang, Ph.D., member of the Cancer Molecular Genetics program at VCU Massey, associate professor in the Department of Human and Molecular Genetics and associate scientific director of immunology and infectious diseases of VIMM; Devanand Sarkar, M.B.B.S., Ph.D., Harrison Scholar and member of the Cancer Molecular Genetics program at VCU Massey, associate professor in the Department of Human and Molecular Genetics at VCU School of Medicine, and associate scientific director of cancer therapeutics at VIMM; Belal Azab, Ph.D., and Michelle E. Menezes, Ph.D., both postdoctoral scientists from the Department of Human and Molecular Genetics at VCU School of Medicine; and Sujit K. Bhutia, Ph.D., Department of Human and Molecular Genetics at VCU School of Medicine, now an assistant professor in the Department of Life Science, National Institute of Technology, Rourkela, India.
This study was supported by National Cancer Institute grants R01 CA097318 and P01 CA104177.
The full manuscript of this study is available at: http://onlinelibrary.wiley.com/doi/10.1002/ijc.28289/abstract;jsessionid=EAF95F3253E44B492D50B8E862E1F55E.d03t03
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Targeted viral therapy destroys breast cancer stem cells ...
Posted: March 27, 2015 at 5:48 pm
While most of us recover from influenza after a week, it can be a very severe disease, and even fatal in rare cases, with no reason for physicians to have expected such an outcome. By analysing the genome of a little girl who contracted a severe form of influenza at the age of two and a half years, researchers at the Laboratory of Human Genetics of Infectious Diseases (a joint French-American international laboratory), which brings together researchers from Inserm, Paris Descartes University, and physicians from the Paris public hospitals (AP-HP; Necker Hospital for Sick Children), working at the Imagine Institute, and from The Rockefeller University in New York, have discovered that she has a genetic mutation, unknown until now, that causes a subtle dysfunction in her immune system. More generally, these results show that genetic mutations could be the root cause of some severe forms of influenza in children, and indicate in any event that immune mechanisms missing in this little girl are needed for protection against this virus in humans. These results are published in the journal Science.
Seasonal influenza is an acute viral infection caused by the influenza virus. It is characterised by high fever, headaches, sore muscles, etc. Apart from vaccination, there is no treatment for it other than symptomatic (pain) treatment. In most cases, patients recover after a week, but in more vulnerable people influenza can cause acute respiratory distress, which is potentially fatal.
The main known risk factors for severe forms of influenza are some acquired comorbidities, such as chronic lung disease. However, the cause of most fatal cases remains unexplained, especially in children.
The absence of cases of severe influenza in patients with known acquired immunodeficiencies, which usually increase susceptibility to infections, is also surprising.
Given these different observations, the researchers at Jean-Laurent Cassanova's and Laurent Abel's laboratory, in Paris and New York, therefore formulated a hypothesis whereby severe influenza in healthy children might be the result of genetic errors.
To test this hypothesis, they sequenced the entire genome of a 7-year-old child who had contracted a severe form of influenza (influenza A virus strain H1N1), requiring her admission to a paediatric intensive care unit in January 2011, at the age of two and a half years. At the time, she showed no other known pathology that might have suggested greater vulnerability to the virus than that of other children.
This analysis, combined with analysis of her parents' genomes, made it possible to show that the little girl had inherited a mutated allele of the gene encoding interferon regulatory factor (IRF7) from both of her parents. The latter is a transcription factor known to amplify the production of interferons in response to viral infection in mice and humans.
In contrast to her parents, in whom the mutation of a single allele of the gene is of no consequence, in the little girl, mutation of both alleles of the gene encoding IRF7 has led to its inactivation. The result: failure to produce interferons, disrupting her system of defence against influenza virus infection in a cascading manner.
By carrying out a comprehensive series of experiments on blood cells, particularly dendritic cells, and by generating lung cells from stem cells taken from the young girl, the researchers provided proof that the mutations observed in this little girl explain the development of severe influenza. Furthermore, this discovery demonstrates that interferon amplification dependent on IRF7 expression is needed for protection against influenza virus in humans. They now need to search for mutations in this or other genes in other children recruited following an episode of unexplained severe influenza.
Based on these initial observations, the researchers at Inserm believe that therapeutic strategies based on recombinant interferons, available in the pharmacopoeia, could help to combat severe forms of influenza in children.
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What if the severity of our seasonal influenza were related to our genetic background?
Posted: March 27, 2015 at 5:45 pm
Developing stem cell therapy as an alternative to corneal transplants.
Professor Julie Daniels talks about her tissue engineering research.
By: Fight for Sight
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Developing stem cell therapy as an alternative to corneal transplants. - Video
