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CPRIT Awards Faculty $11.5 Million for Recruitment and Research in Brain and Bone Cancer, Biology, and Immunotherapy

Posted: March 7, 2015 at 5:06 am

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Newswise DALLAS March 6, 2015 The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded UTSouthwestern Medical Center researchers more than $7.5 million in research grants to improve diagnostic and therapeutic services and research relating to cancers of the brain, breast, throat, and bone, as well as to improve scientific understanding of cancer biology.

UTSouthwestern received an additional $4 million for recruiting emerging cancer scientists. The February awards bring the total awarded by CPRIT to UTSouthwestern for cancer research, recruitments, and prevention efforts to $34 million in fiscal year 2015, more than any other Texas institution.

New research grants were awarded to seven UTSouthwestern researchers at the Harold C. Simmons Comprehensive Cancer Center as part of CPRITs Individual Investigator Research Awards.

The projects by these researchers underscore the vitality of the collaborative effort we value and encourage at the Simmons Cancer Center, and the diversity of approaches that are needed to expand opportunities for those facing a cancer diagnosis, said Dr. James Willson, Associate Dean of Oncology Programs at UTSouthwestern, and Professor and Director of the Simmons Cancer Center, the only National Cancer Institute-designated cancer center in North Texas and one of just 68 in the country. Dr. Willson holds The Lisa K. Simmons Distinguished Chair in Comprehensive Oncology.

Dr. Luis Parada, Chairman of Developmental Biology, Director of the Kent Waldrep Foundation Center for Basic Neuroscience Research, and holder of the Diana K. and Richard C. Strauss Distinguished Chair in Developmental Biology and the Southwestern Ball Distinguished Chair in Nerve Regeneration Research, was awarded $900,000 to study a small chemical compound that stops stem cell growth in gliomas (brain cancer). His lab has been instrumental in identifying molecules that inhibit nerve regeneration after injury.

Dr. Craig Malloy, Professor with the Advanced Imaging Research Center, Internal Medicine, and Radiology, who holds the Richard A. Lange, M.D. Chair in Cardiology, was awarded $897,311 in partnership with Texas A&M University to develop new technologies to study metabolism in breast cancer. This collaboration leverages the strengths in human metabolism at UTSouthwestern, electrical engineering expertise at Texas A&M, and the distinctive 7 Tesla magnetic resonance imaging (MRI) device at the Bill and Rita Clements Advanced Medical Imaging Building at UTSouthwestern. MR images at 7T allow investigators to observe small anatomical structures and to monitor tissue biochemistry without biopsies or radiation.

Dr. Zhijian Chen, Professor of Molecular Biology and with the Center for the Genetics of Host Defense, who holds the George L. MacGregor Distinguished Chair in Biomedical Science, was awarded $889,185 to study how to improve cancer immunotherapy through a pathway called the Cytosolic DNA Sensing Pathway. The pathway induces type-I interferons, which are important for activating cytotoxic T cells to kill tumors.

Dr. Steve Jiang, Professor and Vice Chairman of Radiation Oncology, Chief of the Division of Medical Physics and Engineering, and holder of the Barbara Crittenden Professorship in Cancer Research, was awarded $858,356 to study how to take online adaptive radiotherapy technologies developed in the lab into clinical practice. Online adaptive radiotherapy allows real-time adjustments to provide individualized cancer radiotherapy that can help reduce unwanted exposure to healthy tissues.

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CPRIT Awards Faculty $11.5 Million for Recruitment and Research in Brain and Bone Cancer, Biology, and Immunotherapy

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Twins: Rule 5 pick J.R. Graham feeling 'like I'm back'

Posted: March 7, 2015 at 5:02 am

PORT CHARLOTTE, Fla. -- J.R. Graham will never forget the moment his career flashed before his eyes.

It was Friday the 13th, May 2013, as he warmed up for the start of the third inning on a warm night in Mississippi. The stocky right-hander had entered that season as the third-ranked prospect in the Atlanta Braves system, but something wasn't right after he threw a changeup.

"I felt it start in the back of my shoulder," Graham recalled. "It was just kind of a numb tingling that shot down my arm. It felt like a pinched nerve. I went, 'Ooh.' My fingers were tingling."

He threw another pitch. This time it was a fastball that didn't even reach home plate.

"I just stood there in shock. It was just a moment of panic.

Twins third baseman J.R. Graham throws against Tampa Bay in the seventh inning at Charlotte Sports Park in Port Charlotte, Fla. on Friday, March 6, 2015. The Ray beat the Twins, 2-1. (Pioneer Press: John Autey)

He stood frozen on the mound, staring at catcher Christian Bethancourt. Throughout his career at Livermore (Calif.) High School and Santa Clara University, Graham, 23 at the time, had never had any arm trouble. But the next day, he couldn't even lift his arm.

The official diagnosis was a strained rotator cuff. He was treated with injections of stem cells and platelet-rich-plasma.

"We did both of them, just to make sure," he said. "We weren't messing around."

Typically, such treatments are reserved for elbow injuries. Dr.

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Twins: Rule 5 pick J.R. Graham feeling 'like I'm back'

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Topeka retailer honored as 'business of the year'

Posted: March 7, 2015 at 5:01 am

A downtown Topeka store will be honored as one of 16 businesses of the year by the Kansas Small Business Development Center.

The Merchant, 913 S. Kansas, sells used clothing, accessories, collectibles, art and books. Owner Lisa Boyd will be honored with the owners of the other 15 winning businesses Tuesday before the Kansas House of Representatives and Senate.

Each of the eight regional small business development centers was allowed to recognize an existing business that had been around for at least four years and an emerging one that had existed between two and four years.

Karl Klein, director of the Washburn University SBDC affiliate, said they chose Boyd as one of the winners for the region because of her commitment to her business and efforts to implement advice from the SBDC counselors she worked with, as well as her success continuing the business during construction that limited customer access on Kansas Avenue.

Its been a challenging environment and shes overcome a lot of those challenges, he said. I think theyve done well with attracting business.

Boyd said she started out renting a space in a building at 718 S. Kansas in 2009, and the Washburn University Small Business Development Center helped her develop her plans and get a loan in 2011 to buy the building where the business currently is located. The SBDC also helped with accounting questions as she learned on the job, she said.

I dont really look at it as Ive had challenges, she said. I just look at it as running a business and learning as I go.

The other winner for the region was Manhattan-based Kansas Regenerative Medicine, Klein said.

The clinic uses adult stem cells derived from a patients fat to attempt to treat degenerative diseases and was chosen because of its innovative concept, he said.

Kansas Regenerative Medicine is researching whether the therapy helps a variety of conditions, including joint problems, Parkinsons disease, strokes, lupus, Crohns disease and macular degeneration. The U.S. Food and Drug Administration hasnt approved that type of stem cell treatment for the conditions Kansas Regenerative Medicine is researching, so it cant make claims that the treatment will help, according to the businesss website.

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Topeka retailer honored as 'business of the year'

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Stem Cell Sound Bites: Duchenne Muscular Dystrophy – Video

Posted: March 7, 2015 at 4:51 am

Stem Cell Sound Bites: Duchenne Muscular Dystrophy
Visit: http://www.uctv.tv/) Carrie Miceli and Stanley Nelson of UCLA describe their efforts to use stem cell-based strategies to find a drug treatment for d...

By: University of California Television (UCTV)

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Stem Cell Sound Bites: Duchenne Muscular Dystrophy - Video

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