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Ohio Stem Cell Knee Arthritis Treatment-Regenexx

Posted: February 23, 2015 at 2:59 pm

Can we take a procedure that was invented in Colorado and have it workon a patient who is a Michigan physician,performed by a doctor in Ohio? One of the hallmarks of a good medical procedure is that it can be taught to others and that it works as well in their hands as it did in the inventors. However, accomplishing that in medicine isnt always easy, as medical history is rife with procedures that worked well in early studies and then were abandoned because they didnt easily translate.

Our focus on having our procedure technology work well in the hands of others is why we spend so much time and energy making sure that only physicians with a specific skill set can join our exclusive network. This why our acceptance rate for that stem cell treatment network is lower than getting into Harvard. This is also why we have the worlds most comprehensive educational program for physicians wanting to use stem cells for knee, shoulder, or hip arthritis, bar none. In order to be certified in these areas our physicians must undergo both didactic and hands on training in musculoskeletal ultrasound, fluoroscopy, stem cell harvest techniques, and body part specific techniques (i.e. for knee arthritis). Each of these body areas has a CORE skills checklist of various procedures they must master. When you do all of that, you get great practitioners like Roger Kruse, M.D. in Ohio who know their stuff.

Roger was already an ACE in musculoskeletal ultrasound before he joined up with the RegenexxNetwork. He was team physician for 3 Olympic games and head team physician for the US Olympic Team, Nagano, Japan. He is head physician for the University of Toledo and a assistant clinical professor at their medical school. He also runs a sports medicine fellowship program and is team physician for U.S. Figure Skating. Suffice it to say that Roger is no ordinary doctor.

Dr. Kruse recently sent me a letter from a physician patienthe treated that illustrates the above point. In addition, the other mark of a procedure that works is when physicians begin referring themselves for the treatment. Weve treated many health care providers through the years including many physicians. Suffice it to say that they have been to the puppet show and seen the strings, meaning when it comes to their own healthcare they tend to choose less invasive options. They also do their homework and look for things like research data that supports the procedure. They dig deep before trying something, as they have the knowledge to sort out the real deal from quackery.

Heres the very wonderful letter from one of Rogers physician patients:

November 18, 2014

Thanks Dr. Kruse.But first I have to thank Paul Shapiro MD, my prolo Doc in Ann Arbor Michigan who told me about Regenexx. Without his advice I might have been seduced by some of the stem cell quackery found all around Southeast Michigan.

I was discouraged, though, because of my past surgical history. In 1974 I had a left medial menisectomy for a traumatic bucket-handle tear. I was sure by 2014 with all my competitive triathloning, hiking and walking I would have severe arthritis that would make me a non candidate. Nevertheless, I sent my MRI CD and paperwork to the Regenexx facility in Toledo, Ohio. Lucky for me, Dr. Kruse believed I was a candidate. Glad he did as in 2001, I had a debridement of right medial and lateral meniscus tears from doing extreme yoga. and over the past 5 years I was having difficulty even walking my usual4-5 miles a day. I went to Toledo in July 2014 thinking I would have theprocedure only on my left knee but Dr. Kruse expertly and painlessly injected both my knees. While I am a little uncertain about the results of my left knee, but it seems to be true I have about 60% improvement in my right knee.

Finally, many thanks to Christopher J. Centeno MD who developed and perfected the Regenxx procedure from its roots in equine Veterinary Medicine making this procedure what it is today-a treatment to stop pain and disability for many without extensive traditional orthopedic surgery.

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Ohio Stem Cell Knee Arthritis Treatment-Regenexx

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New York City Pain Specialists Introduce New Treatment for Knee Pain; First Physicians in Northeast to Offer iovera …

Posted: February 23, 2015 at 2:58 pm

Redwood City, CA (PRWEB) February 23, 2015

The iovera system, cleared by the FDA to treat peripheral nerve pain, utilizes its patented Focused Cold TherapyTM delivery system to direct a controlled cold dosage via closed-end probes to specific nerves for precise, predictable, drug-free pain relief.

The iovera treatment provides my knee pain patients with a very effective, natural option that provides relief precisely at their point of pain allowing them, in many cases, to avoid or reduce their need for systemic painkillers, said Sudhir Diwan, M.D., Manhattan Spine and Pain. My patients are excited to have a minimally-invasive, drug-free treatment that enables them to walk out of my office pain-free and stay that way for up to 3 months.

Patients are relieved when they realize that there is a minimally-invasive, non-systemic option that can give them instant knee pain relief, said Halland Chen, M.D., of Dr. Halland Medical. Theres something familiar and comforting to patients about using the simple power of cold to eliminate pain, and with iovera we can now use cold in a very high-tech, precise way to block specific nerve signals temporarily.

Frequent knee pain limits function and mobility, and impairs quality of life for approximately 25% of adults.1 Peripheral nerves treated with the iovera system are temporarily stopped from signalling for a period of time, followed by a restoration of function - results may vary per patient*. Because peripheral nerve function is disrupted rather than destroyed, the results are safe, effective and temporary.

We are so pleased that these pain specialists have seen the unique value of the Focused Cold Therapy delivery system for patients with knee pain, said Jeff Gold, myoscience CEO. The iovera treatment allows physicians to target a patients pain directly at the source by treating the specific peripheral nerves involved with a natural, safe dose of cold that temporarily stops the nerves from signalling and delivers immediate pain relief.

The iovera system delivers liquid nitrous oxide from a convenient and powerful handheld device to the closed-end probes of the Smart Tip during treatment. While this highly pressurized liquid travels from the handpiece to the Smart Tip, it undergoes a phase change becoming very cold, drawing in heat energy from the surrounding tissue and forming a precise zone of cold at thetargeted nerve. The gaseous nitrous oxide returns into the handpiece, leaving nothing behind in the body. This precise cold treatment causes a reversible nerve block based on a process called Wallerian degeneration. Pain is relieved in sensory nerves, which send messages to the central nervous system. The nerve re-innervates 1-2 mm per day, which gives a predictable restoration of nerve function.

About iovera The Food and Drug Administration (FDA) cleared the iovera system for use in peripheral nerves in January 2013. iovera is being used most frequently for knee pain but can be used to treat pain in any peripheral nerve. The iovera system is specifically cleared to destroy tissue during surgical procedures by applying cold temperature. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain. The iovera system is not indicated for treatment of central nervous system tissue.

About the Manhattan Spine and Pain Medicine Manhattan Spine and Pain Medicine physicians listen and treat pain without surgery. Their passion is improving patients quality of life. Pain management is the medical specialty focused solely on treating patients in acute and chronic pain. The practices goal is to restore function and improve the quality of life for those in pain. The board-certified physicians at Manhattan Spine and Pain listen diagnose and treat pain from head to toe using a range of non-surgical treatment options. For more information about the Manhattan Spine and Pain Medicine please visit: https://treatingpain.com/mspm. Patients interested in iovera treatment at Manhattan Spine and Pain can call 877-463-7264.

About Dr. Halland Medical Dr. Halland Chen specializes in pain management. His practice is focused on non-surgical knee and spine treatments, with a special emphasis on regenerative medicine and organic options through the use of PRP, Stem Cells and natural supplements. Dr. Halland Medical applies its unique techniques for patients to address sports injuries, pain management conditions, and cosmetic anti-aging. Dr. Halland specializes in injection therapy and minimally invasive techniques. For more information about Dr. Halland Medical please visit: http://drhalland.com. Patients interested in iovera treatment at Dr. Halland Medical can call: 212-464-8772.

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New York City Pain Specialists Introduce New Treatment for Knee Pain; First Physicians in Northeast to Offer iovera ...

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PowerPoint Presentation

Posted: February 23, 2015 at 2:53 pm

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PowerPoint Presentation

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CIRM's Klein proposes $100B biomed program

Posted: February 23, 2015 at 2:52 pm

Bob Klein describes his vision of how to increase biomedical funding to hasten discovery and commercialization of disease treatments. He spoke Thursday, Feb. 19, at the annual UCSD Moores Cancer Center symposium.

Bob Klein, the main backer of California's 2004 stem cell initiative has proposed a $100 billion international bond program in life sciences, to speed up research and clinical testing of disease therapies. The program would be focused on stem cells and genomics.

The United States and a few other countries would jump-start the program, and other countries would join, said Klein, a real estate investor, at last Thursday's UCSD Moores Cancer Center symposium.

Klein likened the participation to that already taking place in the stem cell cell program, the California Institute for Regenerative Medicine, created by the 2004 initiative, Proposition 71. CIRM has partnered with 14 other countries to co-fund international research projects. Foreign partners fund scientists in their own countries, while CIRM funds California-based scientists. Klein was CIRM's first chairman. Although he left the agency's governing board in 2011, he remains involved in advancing the agency's objectives.

This partnership leverages funding to create a much greater total impact, Klein said in an on-stage interview with Rep Scott Peters, D-San Diego. Peters, one of the post prominent supporters of federal biomedical funding in Congress, represents much of San Diego's biotech heartland of La Jolla and Sorrento Valley. Beside the financing issues, they also discussed ways to increase political support for biomedical research.

Klein, a real estate developer, drew from his knowledge of crafting bonds to describing how the program would work. The bond program would be seeded by a much smaller amount of seed funding through government-supported agencies, creating leverage.

"Just to give you (an idea) of the multiple effect of bringing critical funds upfront in the process, $100 million (a year) in bonds at the World Bank borrowing rate creates about $2.5 billion in bonds that are supported," Klein said. "At a time of scarce resources for Congress, if they would appropriate on a long term commitment to support international bonds, we could really leverage up to maybe a $100 billion program."

Under that program, each participating country would be allocated an amount of upfront financing to pay.

"Because the borrowing is so much cheaper than anything a country can do, from the surplus funds we raise, which are about 35 percent to 40 percent more than most countries can raise from the same amount of money, we can have an international pool, where we can collaborate and compete through peer review," Klein said.

Klein pointed to the International Finance Facility for Immunization as an international public-private partnership as a financial model. Using long-term government pledges as collateral, the agency can raise capital as needed from the bond markets.

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CIRM's Klein proposes $100B biomed program

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Can stem cell therapy save a beloved coach?

Posted: February 23, 2015 at 2:40 pm

The Facebook post late Thursday night landed like a punch to the gut to everyone who knows Jeff Dienhart.

The beloved Central Catholic girls assistant basketball coach, who has been waging a fierce struggle against the suffocating ravages of cystic fibrosis, abruptly announced that the end is now near.

"I was sent home today from the hospital on hospice care. I received the sacrament of confession and the anointing of the sick last night from father Daniel garland. I am at home under medication. Could have days could have weeks could have months no one knows. Just know I am at peace. I am scared and dont want to leave this place on earth.. I have fought so hard for so long. I am so tired and have suffered so much this year .please pray for my wife Valerie my daughter Alicia and my son drew during this tough time."

My husband and I came to the conclusion that he is a fighter. Odds don't mean anything to him.

It was not supposed to end this way. Dienhart was, in fact, just days away from an experimental stem cell treatment that he hoped would extend his life. Friends, family and the community had raised more than $70,000 to cover the costs.

And Dienhart, 44, had beaten so many odds before.

The statistics suggest, for example, that many men with cystic fibrosis are infertile, yet Dienhart fathered two children.

Central Catholic assistant girls basketball coaches Jeff Dienhart, foreground, and Dave Crandall watch the action as the Knights host Guerin Catholic on Jan. 30. It was the first game for Dienhart in quite a while, as he had spent the better part of the month of January in the hospital. Dienhart is set to receive stem cell treatment in the Dominican Republic to hopefully assist in his battle with cystic fibrosis. (Photo: John Terhune/Journal & Courier)

Nor were CF sufferers supposed to be able to play marathon rounds of golf.

"I would tell the doctor he played 36 holes of golf in 90-degree heat," said Dienhart's mother, Kathy Dienhart. "The doctor would tell me I made that up. My husband and I came to the conclusion that he is a fighter. Odds don't mean anything to him."

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Can stem cell therapy save a beloved coach?

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The Future of Treating Heart Disease Is Now (2015) – Video

Posted: February 23, 2015 at 10:45 am


The Future of Treating Heart Disease Is Now (2015)
At the Texas Heart Institute, the future of preventing, diagnosing, and treating heart disease is now. A look at the many ways including regenerative medicine, stem cells, genetics, imaging,...

By: Texas Heart Institute

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The Future of Treating Heart Disease Is Now (2015) - Video

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Stem Cell Research & Therapy | Full text | Aromatic …

Posted: February 22, 2015 at 3:42 pm

Abstract Introduction

Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative disease. Furthermore, the effects of ar-turmerone on neural stem cells (NSCs) remain to be investigated.

We exposed primary fetal rat NSCs to various concentrations of ar-turmerone. Thereafter, cell proliferation and differentiation potential were assessed. In vivo, nave rats were treated with a single intracerebroventricular (i.c.v.) injection of ar-turmerone. Proliferative activity of endogenous NSCs was assessed in vivo, by using noninvasive positron emission tomography (PET) imaging and the tracer [18F]-fluoro-L-thymidine ([18F]FLT), as well as ex vivo.

In vitro, ar-turmerone increased dose-dependently the number of cultured NSCs, because of an increase in NSC proliferation (P<0.01). Proliferation data were supported by qPCR-data for Ki-67 mRNA. In vitro as well as in vivo, ar-turmerone promoted neuronal differentiation of NSCs. In vivo, after i.c.v. injection of ar-turmerone, proliferating NSCs were mobilized from the subventricular zone (SVZ) and the hippocampus of adult rats, as demonstrated by both [18F]FLT-PET and histology (P<0.05).

Both in vitro and in vivo data suggest that ar-turmerone induces NSC proliferation. Ar-turmerone thus constitutes a promising candidate to support regeneration in neurologic disease.

Curcumin and ar-turmerone are the major bioactive compounds of the herb Curcuma longa. Although many studies have demonstrated curcumin to possess antiinflammatory and neuroprotective properties (reviewed by [1]), to date, the effects of ar-turmerone remain to be elucidated. For example, antitumor properties, exerted via the induction of apoptosis [2] and inhibition of tumor cell invasion [3], have been attributed to ar-turmerone. Park et al. [4,5] recently suggested that ar-turmerone also possesses antiinflammatory properties resulting from the blockade of key signaling pathways in microglia. Because microglia activation is a hallmark of neuroinflammation and is associated with various neurologic disorders, including neurodegenerative diseases [6,7] and stroke [8,9], ar-turmerone constitutes a promising therapeutic agent for various neurologic disorders.

The regenerative potential of endogenous neural stem cells (NSCs) plays an important role in neurodegenerative disease and stroke. Endogenous NSCs are mobilized by cerebral ischemia [10] as well as by various neurodegenerative diseases [11,12], although their intrinsic regenerative response is insufficient to enable functional recovery. The targeted (that is, pharmacologic) activation of endogenous NSCs has been shown to enhance self-repair and recovery of function in the adult brain in both stroke [13,14] and neurodegeneration [15]. Importantly, NSCs and microglia relevantly interact with each other, thereby affecting their respective functions [16,17].

Thus, with the perspective of ar-turmerone as a therapeutic option in mind, we investigated the effects of ar-turmerone on NSCs in vitro and in vivo.

NSCs were cultured from fetal rat cortex at embryonic day 14.5, as described previously [18]. Cells were expanded as monolayer cultures in serum-free DMEM/F12 medium (Life Technologies, Darmstadt, Germany) with N2 supplement (Gibco, Karlsruhe, Germany) and fibroblast growth factor (FGF2; 10ng/ml; Invitrogen, Karlsruhe, Germany) for 5days and were replated in a 24-well plate at 10,000 cells per cm2. FGF2 was included throughout the experiments.

Ar-turmerone (Fluka, Munich, Germany) was added to cultures at replating at concentrations of 0, 1.56, 3.125, 6.25, 12.5, and 25g/ml. All experiments were performed in triplicate. After 72hours, representative pictures were taken by using an inverted fluorescence phase-contrast microscope (Keyence BZ-9000E). Three images were taken per well, and cells were counted by using the software ImageJ with a threshold of 20 px (National Institutes of Health, Bethesda, MD, USA, Version 1.47k).

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Stem Cell Research & Therapy | Full text | Aromatic ...

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Why Stem Cell Therapy? – Video

Posted: February 22, 2015 at 3:40 pm


Why Stem Cell Therapy?
Dr. Bryn J. Henderson (DO, JD, FACPE, CIME) is visionary physician executive leading RMG. In this amazing education video, he is explaning clearly why patients should choose Stem Cell Therapy...

By: iManifestart

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Why Stem Cell Therapy? - Video

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Nature : Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells – Video

Posted: February 22, 2015 at 6:41 am


Nature : Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Dagmar Walter et al (2015), Nature http://dx.doi.org/10.1038/nature141...

By: KeSimpulan

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Nature : Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells - Video

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Stem Cell Therapy for Liver Failure Cirrhosis Kidney Damage – 6 Months After Stemcell Transplant – Video

Posted: February 22, 2015 at 6:41 am


Stem Cell Therapy for Liver Failure Cirrhosis Kidney Damage - 6 Months After Stemcell Transplant
Bruce from Perth Australia give us an update 6 Months After his cord Mesenchymal stem cell treatment for Iiver cirrhosis, kidney complications in Thailand: More here: http://stemcellthailand.org/th...

By: Regeneration Center of Thailand

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Stem Cell Therapy for Liver Failure Cirrhosis Kidney Damage - 6 Months After Stemcell Transplant - Video

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