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After losing father to cancer, Scotus graduate finds way to fight back

Posted: February 13, 2015 at 3:55 pm

OMAHA When Bill Gannon went to the doctor complaining of back pain, he wasnt expecting the news he got.

In September 2011, the former president of Scotus Central Catholic a title he held from 1997 to 2006 was diagnosed with multiple myeloma.

Although the diagnosis was hard for his family to handle, Bill stayed strong.

He was very confident he was going to beat this, not once did he waver from a setback, said Chris Gannon, who describes his father as a determined, stoic, positive and stubborn man.

The Gannons turned to the Leukemia and Lymphoma Society (LLS), searching for answers, treatment options and information on this type of cancer.

We hadnt even heard of myeloma until the doctors sat us down and had a talk with us. LLS helped us understand everything from coping assistance to travel vouchers. They even showed us educational things, said Chris, a 1999 graduate of Scotus Central Catholic.

The Gannon family learned multiple myeloma attacks white blood cells. It's also rare, as fewer than 25,000 people are diagnosed with the cancer each year.

During his treatments, Bill continued teaching in Schuyler. He planned to finish the school year, but was forced to retire in October 2012 after a failed stem-cell transplant.

He never doubted he wouldnt beat it until the last two weeks of his life. He finally realized there was nothing left they could do, Chris said. It just got too aggressive, even though we had been trying everything at that point in time.

Bill lost his battle with cancer in January 2013.

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Frozen Zoo holds key to survival for some species

Posted: February 13, 2015 at 3:52 pm

ESCONDIDO, Calif. (AP) Whenever an endangered animal dies at the San Diego Zoo, researchers race out, regardless of the hour, to remove its sperm or eggs, maybe a bit of ear or eyeball, and carefully freeze the cells in liquid nitrogen.

Today, the survival of the northern white rhinoceros and dozens of other species could hinge on the collection amassed over nearly 40 years that has become the largest gene bank of its kind: The Frozen Zoo.

The icy vials may someday even be used in experiments to resurrect recently extinct animals, like the Hawaiian Poouli bird. The stainless steel tanks hold the genetic material of more than 10,000 individual animals from more than 1,000 species and subspecies.

The Frozen Zoos work has taken on renewed urgency since the San Diego Safari Park lost 42-year-old Angalifu to cancer in December, leaving only five northern white rhinos left in the world and all unable to reproduce.

Scientists are racing against the clock to find the best way to utilize the banks frozen sperm to produce another one before the northern white goes extinct, which could happen within a decade.

Critics question whether its worth spending millions of dollars on species that are down to so few.

The bank is valued as a genetic archive that has helped advance artificial insemination, in vitro fertilization, cloning and stem cell technology. But debate is stirring over how far such research should go.

The frozen zoo is basically re-arranging the deck chairs on the Titanic, said Paul Ehrlich, a senior fellow at the Stanford Woods Institute for the Environment at Stanford University.

He noted the world needs to address the problems root causes, such as population growth and climate change.

Screwing around with science to save a white rhino might be fun and I would like to see it preserved and am all for biodiversity, but its so far down the list of things we should be doing first, he said.

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The Kitchen Sink Salad! Eat Your Natural DHT Blockers and Wake Up Your Stem Cells! Grow Your Hair! – Video

Posted: February 13, 2015 at 8:40 am


The Kitchen Sink Salad! Eat Your Natural DHT Blockers and Wake Up Your Stem Cells! Grow Your Hair!
Dee Carter shows you how to create a salad masterpiece! How to eat to grow your hair.

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Jonathan donating blood stem cells – Feb. 2014 – Video

Posted: February 13, 2015 at 8:40 am


Jonathan donating blood stem cells - Feb. 2014
Gift of Life donor Jonathan donated his blood stem cells February 2014 to a patient with Acute Lymphoblastic Leukemia!

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The Cancer Stem Cell Theory – Video

Posted: February 13, 2015 at 8:40 am


The Cancer Stem Cell Theory
The European Cancer Stem Cell Research Institute at Cardiff University believes that cancer stem cells are responsible for the spread and regrowth of tumours...

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A Pancreas in a Capsule

Posted: February 12, 2015 at 10:50 am

Stem-cell advocates pin their hopes on an artificial pancreas to treat diabetes.

Fourteen years ago, during the darkest moments of the stem-cell wars pitting American scientists against the White House of George W. Bush, one group of advocates could be counted on to urge research using cells from human embryos: parents of children with type 1 diabetes. Motivated by scientists who told them these cells would lead to amazing cures, they spent millions on TV ads, lobbying, and countless phone calls to Congress.

Now the first test of a type 1 diabetes treatment using stem cells has finally begun. In October, a San Diego man had two pouches of lab-grown pancreas cells, derived from human embryonic stem cells, inserted into his body through incisions in his back. Two other patients have since received the stand-in pancreas, engineered by a small San Diego company called ViaCyte.

Its a significant step, partly because the ViaCyte study is only the third in the United States of any treatment based on embryonic stem cells. These cells, once removed from early-stage human embryos, can be grown in a lab dish and retain the ability to differentiate into any of the cells and tissue types in the body. One other study, since cancelled, treated several patients with spinal-cord injury (see Geron Shuts Down Pioneering Stem-Cell Program and Stem-Cell Gamble), while tests to transplant lab-grown retina cells into the eyes of people going blind are ongoing (see Stem Cells Seem Safe in Treating Eye Disease).

Type 1 diabetes is especially hard on children. If they dont manage their glucose properly, they could suffer nerve and kidney damage, blindness, and a shortened life span.

Type 1 patients must constantly monitor their blood glucose using finger pricks, carefully time when and what they eat, and routinely inject themselves with insulin that the pancreas should make. Insulin, a hormone, triggers the removal of excess glucose from the blood for storage in fat and muscles. In type 1 diabetics, the pancreas doesnt make it because their own immune system has attacked and destroyed the pancreatic islets, the tiny clusters of cells containing the insulin-secreting beta cells.

The routine is especially hard on children, but if they dont manage their glucose properly, they could suffer nerve and kidney damage, blindness, and a shortened life span. Yet despite years of research, there is still just nothing to offer patients, says Robert Henry, a doctor at the University of California, San Diego, whose center is carrying out the surgeries for ViaCyte.

Henry slightly overstates the case, but not by much. There is something called the Edmonton Protocol, a surgical technique first described in the New England Journal of Medicine in 2000. It used islets collected from cadavers; by transplanting them, doctors at the University of Alberta managed to keep all seven of their first patients off insulin for an entire year.

Early hopes for the Edmonton Protocol were quickly tempered, however. Only about half of patients treated have stayed off insulin long-term, and the procedure, which is still regarded as experimental in the U.S., isnt paid for by insurance. It requires recipients to take powerful immune-suppressing drugs for life. Suitable donor pancreases are in extremely short supply.

The early success of the Edmonton Protocol came only two years after the discovery of embryonic stem cells, in 1998. Those pressing for a diabetes cure quickly set a new goal: pair something like the Edmonton Protocol with the technology of lab-grown beta cells, the supplies of which are theoretically infinite.

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A Pancreas in a Capsule

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Creation Of Rejuvenated Cell By Stem Cell Therapy – The Line Clinic – Video

Posted: February 12, 2015 at 10:43 am


Creation Of Rejuvenated Cell By Stem Cell Therapy - The Line Clinic
Stem cell therapy has become reality which was just possibilities and thoughts of science few days before. This amazing innovation makes life more secured an...

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Stem Cells from Placenta Show Promise for Treating Heart Failure

Posted: February 12, 2015 at 5:59 am

Durham, NC (PRWEB) February 11, 2015

Stem cells collected from placenta, which is generally discarded after childbirth, show promise as a treatment for heart failure. Found in the latest issue of STEM CELLS Translational Medicine, a new study using mice determined that human-derived adherent cells (PDAC cells) significantly improved cardiac function when injected into the heart muscle.

Currently, about 6 million people in the United States alone suffer from heart failure, which is when the hearts pumping power is weaker than normal. Despite intensive medical care, almost 80 percent of people die within eight years of diagnosis, making it the worlds leading cause of death. Heart failure can be the result of coronary artery disease, heart attack and other conditions such as high blood pressure and valve disease.

Cell therapies for cardiac repair have generated considerable interest in recent years. While earlier studies using autologous bone marrow transplantation (that is, stem cells collected from the patients own bone marrow) helped improve cardiac function after myocardial infarction (MI), more recent studies showed no benefit in the early stages after MI. This has led researchers to question whether mesenchymal stem cells from sources other than bone marrow, such as cord blood and placenta tissue, might yield better results.

Among those interested in this is an international team co-led by Patrick C.H. Hsieh of Taiwans Institute of Biomedical Sciences, Academia Sinica, Taipei, and Uri Herzberg of Celgene Cellular Therapeutics, Warren, New Jersey, U.S. They recently undertook a study to test the therapeutic effects of PDA-001, an intravenous formulation of PDAC cells, in mice. The researchers were also testing the best way to deliver the therapy.

Three weeks after chronic heart failure was induced in the animals they were treated with the stem cells by either direct intramyocardial (IM) or intravenous (IV) injection, Dr. Hsieh said. The results showed that the IM injections significantly improved the left ventricle systolic and diastolic functions compared with injection of vehicle or IV injection of PDA-001.

The IM injections also decreased cardiac fibrosis in the vicinity of the injection sites. We repeatedly observed improvement of cardiac function in the injected sites following IM PDA-001 treatment, Dr. Herzberg added. Based on these results, we want to continue our investigations to optimize the effect through controlling the dose, timing and delivery.

In this animal model of progressive heart injury, stem cells isolated from placenta showed promise as an off-the-shelf therapy for cardiac repair, warranting the need for testing in additional models," said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine.

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The full article, Human Placenta-derived Adherent Cells Improve Cardiac Performance in Mice with Chronic Heart Failure, can be accessed at http://stemcellstm.alphamedpress.org/content/early/2015/02/09/sctm.2014-0135.full.pdf+html.

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"Frozen Zoo" is some species' last hope for survival

Posted: February 12, 2015 at 5:55 am

ESCONDIDO, Calif. -- Whenever an endangered animal dies at the San Diego Zoo, researchers race out, regardless of the hour, to remove its sperm or eggs, maybe a bit of ear or eyeball, and carefully freeze the cells in liquid nitrogen.

Today, the survival of the northern white rhinoceros and dozens of other species could hinge on the collection amassed over nearly 40 years that has become the largest gene bank of its kind: The Frozen Zoo.

The icy vials may someday even be used in experiments to resurrect recently extinct animals, like the Hawaiian Po'ouli bird. The stainless steel tanks hold the genetic material of more than 10,000 individual animals from more than 1,000 species and subspecies.

The Frozen Zoo's work has taken on renewed urgency since the San Diego Safari Park lost 42-year-old Angalifu to cancer in December, leaving only five northern white rhinos left in the world - and all unable to reproduce.

Scientists are racing against the clock to find the best way to utilize the bank's frozen sperm to produce another one before the northern white goes extinct, which could happen within a decade.

Critics question whether it's worth spending millions of dollars on species that are down to so few.

The bank is valued as a genetic archive that has helped advance artificial insemination, in vitro fertilization, cloning and stem cell technology. But debate is stirring over how far such research should go.

11 Photos

The annual animal count at the London Zoo

"The frozen zoo is basically re-arranging the deck chairs on the Titanic," said Paul Ehrlich, a senior fellow at the Stanford Woods Institute for the Environment at Stanford University.

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Stem Cell Transplants May Work Better than Existing Drug for Severe Multiple Sclerosis

Posted: February 12, 2015 at 5:44 am

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Newswise MINNEAPOLIS Stem cell transplants may be more effective than the drug mitoxantrone for people with severe cases of multiple sclerosis (MS), according to a new study published in the February 11, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

The study involved 21 people whose disability due to MS had increased during the previous year even though they were taking conventional medications (also known as first-line treatments). The participants, who were an average age of 36, were at an average disability level where a cane or crutch was needed to walk.

In MS, the bodys immune system attacks its own central nervous system. In this phase II study, all of the participants received medications to suppress immune system activity. Then 12 of the participants received the MS drug mitoxantrone, which reduces immune system activity. For the other nine participants, stem cells were harvested from their bone marrow. After the immune system was suppressed, the stem cells were reintroduced through a vein. Over time, the cells migrate to the bone marrow and produce new cells that become immune cells. The participants were followed for up to four years.

This process appears to reset the immune system, said study author Giovanni Mancardi, MD, of the University of Genova in Italy. With these results, we can speculate that stem cell treatment may profoundly affect the course of the disease.

Intense immunosupression followed by stem cell treatment reduced disease activity significantly more than the mitoxantrone treatment. Those who received the stem cell transplants had 80 percent fewer new areas of brain damage called T2 lesions than those who received mitoxantrone, with an average of 2.5 new T2 lesions for those receiving stem cells compared to eight new T2 lesions for those receiving mitoxantrone.

For another type of lesion associated with MS, called gadolinium-enhancing lesions, none of the people who received the stem cell treatment had a new lesion during the study, while 56 percent of those taking mitoxantrone had at least one new lesion.

Mancardi noted that the serious side effects that occurred with the stem cell treatment were expected and resolved without permanent consequences.

More research is needed with larger numbers of patients who are randomized to receive either the stem cell transplant or an approved therapy, but its very exciting to see that this treatment may be so superior to a current treatment for people with severe MS that is not responding well to standard treatments, Mancardi said.

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