Posted: February 7, 2015 at 2:41 pm
STEM CELLS EMBRYOS: ABC Lateline: Alan Trounson David van Gend - 14/8/2002
ABC TV LATELINE "Stem cells: science and ethics clash" - 14/8/2002 TRANSCRIPT at http://www.abc.net.au/lateline/stories/s649062.htm A debate just prior to th...
By: David van Gend
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STEM CELLS & EMBRYOS: ABC Lateline: Alan Trounson & David van Gend - 14/8/2002 - Video
Posted: February 7, 2015 at 2:41 pm
Luminesce Uses Stem Cells for Anti-Aging Skin
By: Karina Palmer
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Luminesce Uses Stem Cells for Anti-Aging Skin - Video
Posted: February 7, 2015 at 2:41 pm
FAQ Part 2: MEsenchymal Stem cell therapy for CAnadian MS patients (MESCAMS)
The Multiple Sclerosis Society of Canada and the Multiple Sclerosis Scientific Research Foundation have announced a $4.2 million grant in support of the MEsenchymal Stem cell therapy for CAnadian.
By: MSSocietyCanada
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FAQ Part 2: MEsenchymal Stem cell therapy for CAnadian MS patients (MESCAMS) - Video
Posted: February 7, 2015 at 6:52 am
STEM CELLS EMBRYOS: ABC Lateline: Alan Trounson David van Gend - 14/8/2002
ABC TV LATELINE "Stem cells: science and ethics clash" - 14/8/2002 TRANSCRIPT at http://www.abc.net.au/lateline/stories/s649062.htm A debate just prior to th...
By: David van Gend
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STEM CELLS & EMBRYOS: ABC Lateline: Alan Trounson & David van Gend - 14/8/2002 - Video
Posted: February 7, 2015 at 6:52 am
HIROSHIMA In a world first, a team at Hiroshima University Hospital on Friday conducted regenerative knee surgery using a technique that employs magnets to concentrate iron-laced stem cells around damaged cartilage, it said.
The endoscopic surgery is less arduous for the patient, said the team led by Mitsuo Ochi, a professor at the hospital. Conventional treatment requires two operations to repair cartilage.
It will take at least a year to determine the effectiveness of the regenerative technique, though previous tests on animals have proven successful, it said.
The team plans to conduct further operations to reaffirm the regenerative surgerys safety in clinical research.
In the operation, the team extracted mesenchymal stem cells from bone marrow of an 18-year-old female high school student and cultivated them with a dash of iron powder to create magnetic stem cells that can develop into various tissues.
The team injected the iron-laced stem cells into the patients right knee joint and used the magnet to concentrate them in areas where cartilage was lost. The stem cells are expected to develop into cartilage.
Cartilage absorbs shock and reduces friction between bones so everything moves smoothly, but its regenerative abilities are limited.
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Hospital pioneers Magneto-style stem cell surgery
Posted: February 7, 2015 at 6:44 am
Knee arthritis; 2 years after stem cell therapy by Harry Adelson, N.D.
By: Harry Adelson, N.D.
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Knee arthritis; 2 years after stem cell therapy by Harry Adelson, N.D. - Video
Posted: February 6, 2015 at 12:40 pm
For patients with brain cancer, radiation is a powerful and potentially life-saving treatment, but it can also cause considerable and even permanent injury to the brain. Now, through preclinical experiments conducted in rats, Memorial Sloan Kettering Cancer Center researchers have developed a method to turn human stem cells into cells that are instructed to repair damage in the brain. Rats treated with the human cells regained cognitive and motor functions that were lost after brain irradiation. The findings are reported in the February 5 issue of the journal Cell Stem Cell.
During radiation therapy for brain cancer, progenitor cells that later mature to produce the protective myelin coating around neurons are lost or significantly depleted, and there is no treatment available to restore them. These myelinating cells--called oligodendrocytes--are critical for shielding and repairing the brain's neurons throughout life.
A team led by neurosurgeon Viviane Tabar, MD, and research associate Jinghua Piao, PhD, of the Memorial Sloan Kettering Cancer Center in New York City, wondered whether stem cells could be coaxed to replace these lost oligodendrocyte progenitor cells. They found that this could be achieved by growing stem cells--either human embryonic stem cells or induced pluripotent stem cells derived from skin biopsies--in the presence of certain growth factors and other molecules.
Next, the investigators used the lab-grown oligodentrocyte progenitor cells to treat rats that had been exposed to brain irradiation. When the cells were injected into certain regions of the brain, brain repair was evident, and rats regained the cognitive and motor skills that they had lost due to radiation exposure. The treatment also appeared to be safe: none of the animals developed tumors or inappropriate cell types in the brain.
"Being able to repair radiation damage could imply two important things: improving the quality of life of survivors and potentially expanding the therapeutic window of radiation," said Dr. Tabar. "This will have to be proven further, but if we can repair the brain effectively, we could be bolder with our radiation dosing, within limits." This could be especially important in children, for whom physicians deliberately deliver lower radiation doses.
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The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.
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Human stem cells repair damage caused by radiation therapy for brain cancer in rats
Posted: February 6, 2015 at 7:47 am
Norm Drives Nearly 4 Hours For Stem Cell Treatments From Dr Baumgartner in Minnesota
http://www.RejuvMedical.com/pages/stemcelltreatments This patient was willing to drive further to avoid a knee surgery. Stem Cell Treatments on his knee have...
By: Rejuv Medical
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Norm Drives Nearly 4 Hours For Stem Cell Treatments From Dr Baumgartner in Minnesota - Video
Posted: February 5, 2015 at 10:50 pm
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Newswise La Jolla, Calif., February 5, 2015 Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered a precise stem cell signaling process that can lead to intestinal tumors if disrupted. The findings add to our understanding of how stem cells give rise to tumors and identify specific stem cell molecules that may be targeted to prevent the onset, progression, and recurrence of intestinal cancers. The results of the study appear online in Cell Reports today.
Accumulating evidence suggests that cancer stem cells are responsible for cancer initiation, progression, metastasis, recurrence, and drug resistance, said Jorge Moscat, Ph.D., program director of the Cell Death and Survival Networks Program at Sanford-Burnham. Our new research provides a better understanding of the signaling cascades that regulate stem cells and is essential for the design of new and more-efficacious therapies for cancer.
We have shown that protein kinase C-zeta (PKC-zeta) normally inhibits stem cell activity through downregulation of two signaling pathways: beta-catenin and Yap, said Maria Diaz-Meco, Ph.D., senior co-author of the paper and professor in the Program. Previously, our lab showed that PKC-zeta acts as a tumor suppressor that maintains homeostasis of intestinal stem cells. The current study reveals the mechanism by which this occurs.
The intestine is covered by a single layer of epithelial cells that are renewed every 3 to 5 days. The pool of cells that replace these epithelial cellsintestinal stem cellsneeds to be regulated to maintain homeostasis.
Disturbing the homeostasis of the stem cell pool can go two waysit can either reduce intestinal epithelial cell regeneration or increase the proliferation of stem cells, said Diaz-Meco. Cancer is produced by the accumulation of mutations in critical genes that control central mechanisms of cell growth. Stem cells are a permanent population in the intestine and a reservoir for those mutations. Therefore, if stem cell activity is increased, as in the case of intestines deficient in PKC-zeta, then the likelihood of developing tumors is much higher, and when the tumor is initiated it becomes more aggressive.
Using a genetically engineered mouse model for intestinal cancer, the research team found that this process is kept under control by direct phosphorylation by PKC-zeta of two essential tumor promoters: beta-catenin and Yap.
Importantly, we confirmed the tumorigenic profiles of PKC-zeta, beta-catenin, and Yap in human colon adenocarcinoma samples. The correlation of human results with our in-vivo mouse studies strongly suggests that Yap and beta-catenin are potential targets of PKC-zeta function and potential targets for new anti-cancer therapies.
"Our results offer new possibilities for the prevention and treatment of intestinal cancers by blocking the pathways that lead to tumors, said Moscat. "They also highlight a new strategy to promote intestinal regeneration after acute or chronic damage, such as that triggered by chemotherapy and radiation.
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New Study Sheds Light on Cancer Stem Cell Regulation
Posted: February 5, 2015 at 10:49 pm
04.02.2015 - (idw) University of Gothenburg
New studies by Swedish researchers at institutions including the University of Gothenburg and Karolinska Institute are questioning the notion that infertility can be treated with stem cells. Whether or not infertility can be treated with stem cells has been a matter of debate for many years.
The classical theory is based on the idea that the eggs a woman has are the ones she has had from birth, but there are researchers who claim that stem cell research could lead to the creation of new eggs. If so, this would mean that infertile women, such as those who have entered the menopause, could be given new eggs.
New studies done by researchers at the University of Gothenburg and Karolinska Institute now show that the dream of successfully treating infertility with stem cells will probably not be realised. These new research studies have been published in the renowned journal Proceedings of the National Academy of Sciences (PNAS).
"Ever since 2004, the studies on stem cell research and infertility have been surrounded by hype. There has been a great amount of media interest in this, and the message has been that the treatment of infertility with stem cells is about to happen. However, many researchers, including my research group, have tried to replicate these studies and not succeeded. This creates uncertainty about whether it is at all possible to create new eggs with the help of stem cells, says Kui Liu, a researcher at the Department of Chemistry and Molecular Biology at the University of Gothenburg.
This shows not only that the use of stem cell research in the clinical treatment of childlessness is unrealistic but also that clinics should focus on using the eggs that women have had since birth in treating infertility, says Professor Kui Liu.
Dr. Kui Liu is a Professor at the Department of Chemistry and Molecular Biology at the University of Gothenburg. His group specialises in the study of the genetic and epigenetic regulation of female germ cell development. Research in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.
For more information, please contact: Professor Kui Liu: Tel. (+46) 70-8887793; kui.liu@gu.se
Link to the article in the Proceedings of the National Academy of Sciences: http://www.pnas.org/content/early/2014/11/25/1421047111.abstract Weitere Informationen:http://www.gu.se/english/about_the_university/news-calendar/News_detail/?languag...
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Swedish Researchers Question Treatment of Infertility with Stem Cells
