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UCSD scientists awarded $2.7M grants for stem cell research

Posted: February 3, 2015 at 3:59 am

LA JOLLA (CNS) - Two scientists with UC San Diego were awarded a combined $2.7 million in grants from the California Institute for Regenerative Medicine to pursue their studies on stem cell therapies, the school announced Monday.

Shyni Varghese, an associate professor in the Department of Bioengineering and director of the Bio-Inspired Materials and Stem Cell Engineering Laboratory, received a $1.4 CIRM grant to improve the function of transplanted stem cells.

Shaochen Chen, a professor in the Department of Nanoengineering in the Jacobs School of Engineering and a member of UCSD's Institute of Engineering in Medicine, received $1.3 million to develop three-diminensional bioprinting techniques that use heart muscle cells derived from human embryonic stem cells to create new cardiac tissue.

The awards were part of almost $30 million in grants announced at CIRM's monthly meeting in San Francisco, according to UCSD.

"Sometimes even the most promising therapy can be derailed by a tiny problem," said Jonathan Thomas, chairman of the CIRM Board of Directors. "These awards are designed to help find ways to overcome those problems, to bridge the gaps in our knowledge and ensure that the best research is able to keep progressing and move out of the lab and into clinical trials in patients."

Varghese's lab focuses on the interactions of cells with their surrounding micro-environment, and how the conditions necessary to promote normal, healthy survival and growth occur, according to UCSD.

Chen's studies focus on using stem cells to create new heart tissue that would help patients when transplants aren't immediately available.

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UCSD scientists awarded $2.7M grants for stem cell research

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Blue Skies the future of regenerative medicine – Video

Posted: February 2, 2015 at 10:50 am

Blue Skies the future of regenerative medicine
Dr. Stephen Minger, Chief Scientist of GE Healthcare Life Sciences, is one of the world #39;s leading experts on stem cells. In this London Futurists talk, he reviews the state of play with stem...

By: London Futurists

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Christian singer Carman shares testimony of cancer victory

Posted: February 2, 2015 at 6:00 am

(Photo: Facebook/Carman)

Carman during and after cancer treatment.

Platinum recording artist Carman shared before and after photos with his Facebook fans on Tuesday following his successful cancer treatment.

Carman, born Carmelo Licciardello, was diagnosed with myeloma in February 2013, and given only a few years to live. This week, he reflected on how far he has come, and thanked God that he remains cancer-free.

"I remember so well washing my hair after the 3rd week of chemotherapy and seeing it all come off in my hands in clumps," Carman wrote. He shared a photo of himself bald and receiving chemo juxtaposed with a photo of himself nine months later, healthy and with a full head of hair.

"I remember the agony of that giant needle in my sternum to draw out stem cells," he continued.

"The ports they planted in my chest to daily inject drugs. The mind numbing pain of my bones expanding to produce stem cells. Sleeping in the bathroom for days because I'd throw up so often."

The singer also detailed the extreme weight loss and weight gain he experienced while receiving chemotherapy, and nearly dying after catching pneumonia. Through it all, Carman said he never questioned God.

"But I also remember God's grace," he said. "I remember never getting angry or depressed. Never feeling abandoned or hopeless. It was the valley of the shadow of death but I feared no evil."

Now, the 59-year-old is "strong and cancer free," and gearing up for the second leg of the "No Plan B" tour which begins in Alabama on February 12. He encouraged others to put their faith in God when they face trials.

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Christian singer Carman shares testimony of cancer victory

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Types of Stem Cells – Biology Slideshow – Biology …

Posted: February 2, 2015 at 5:53 am

Types of Stem Cells Stem cells can be categorized into five types based on their ability to differentiate or their potency. The stem cell types are as follows: Totipotent Stem Cells These stem cells have the ability to differentiate into any type of cell in the body. Totipotent stem cells develop during sexual reproduction when male and female gametes fuse during fertilization to form a zygote. The zygote is totipotent because its cells can become any type of cell and they have limitless replicative abilities. As the zygote continues to divide and mature, its cells develop into more specialized cells called pluripotent stem cells. Pluripotent Stem Cells These stem cells have the ability to differentiate into several different types of cells. Specialization in pluripotent stem cells is minimal and therefore they can develop into almost any type of cell. Embryonic stem cells and fetal stem cells are two types of pluripotent cells.

- Induced pluripotent stem cells (iPS cells) are genetically altered adult stem cells that are induced or prompted in a laboratory to take on the characteristics of embryonic stem cells. Although iPS cells behave like and express some of the same genes that are expressed normally in embryonic stem cells, they are not exact duplicates of embryonic stem cells.

- Mesenchymal stem cells are multipotent cells of bone marrow that have the ability to differentiate into several types of specialized cells related to, but not including blood cells. These stem cells give rise to cells that form specialized connective tissues, as well as cells that support the formation of blood.

Sources:

Photo Credit: Image: Nissim Benvenisty (PLoS Biol 3(7): e234. doi:10.1371/journal.pbio.0030234)

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California Stem Cell Report: California Stem Cell CEO …

Posted: February 2, 2015 at 5:52 am

Speculation surfaced this week but was quickly squelched that Mahendra Rao, until recently the head of the federal Center for Regenerative Medicine, is a candidate to become the new president of the $3 billion California stem cell agency.

She wrote,

In the wake of the story, the California Stem Cell Report learned that Rao is not a current candidate for the California stem cell agency position. He is also not expected to take a fulltime research position in California. Rao did not respond to an email inquiry about the matter. (The New York Stem Cell Foundation announced later that it has hired Rao as vice president for regenerative medicine.)

Meanwhile, the agency is still on schedule to hire a new CEO by the end of May, according to Kevin McCormack, senior director of public communications. The current president, Alan Trounson, announced last fall that he was leaving to return to his family in Australia.

The agency's presidential search committee has scheduled a two-day, closed-door meeting for next Tuesday and Wednesday to screen candidates. According to the agency's timetable, the teleconference session is intended to produce the finalists for the job, who will undergo additional interviews either late this month or early next month. A vote by the agency's 29-member governing board is expected at its meeting in San Diego May 29.

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TiGenix: TiGenix participates in key conferences in the first half of 2015

Posted: February 2, 2015 at 5:51 am

PRESS RELEASE

TiGenix participates in key conferences in the first half of 2015

Leuven (BELGIUM) - 30 January, 2015 - TiGenix NV (Euronext Brussels: TIG), an advanced biopharmaceutical company focused on developing and commercialising novel therapeutics from its proprietary platform of allogeneic, expanded adipose-derived stem cells, or eASC's, in inflammatory and autoimmune diseases, announced today the conferences in which it is participating during the first half of 2015.

12-14 January Biotech Showcase 2015, San Francisco, USA Presenter: Eduardo Bravo, Chief Executive Officer

26-28 January Phacilitate Cell and Gene Therapy Conference, Washington, USA Presenter: Wilfried Dalemans, Chief Technical Officer

3 February Biotech and Money London 2015, London, UK Presenter: Eduardo Bravo, Chief Executive Officer

9-10 February Bio CEO and Investor Conference, New York, USA Presenter: Eduardo Bravo, Chief Executive Officer

18-21 February ECCO Inflammatory Bowel Diseases Congress, Barcelona, Spain Participants: Marie-Paule Richard, Chief Medical Officer; Maria Pascual, Vice President Regulatory Affairs and Corporate Quality; Mary Carmen Diez, Vice President Medical Affairs and New Product Commercialisation

9-11 March Bio Europe Spring 2015, Paris, France Participant: Claudia Jimenez, Senior Director Business Development

11 March Petercam Belgium Investor Day, Milan, Italy Participant: Claudia D'Augusta, Chief Financial Officer

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TiGenix: TiGenix participates in key conferences in the first half of 2015

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The miraculous healing powers of oxygen

Posted: February 2, 2015 at 5:51 am

Paratrooper Ben Parkinson, who lost both legs aged just 22, meets Princess Anne

The course of treatment depends on the individual patient, explains Prof James. It can be extremely arduous and is no quick fix. Ben will probably have 20 one-hour sessions over the next month and then be reviewed.

Prof James, 73, emeritus professor of hyperbaric medicine at the University of Dundee, is one of the UKs foremost experts in the subject, having spent most of his professional life involved in deep sea diving, where high levels of oxygen are routinely used for brain and spinal cord injuries.

His book, Oxygen and the Brain, which took him 20 years to write, was published at the end of last year . He passionately believes that hyperbaric oxygen therapy (HBOT), still regarded with suspicion by much of the medical establishment, can be used to improve the treatment of a range of disorders, from traumatic brain injury like Bens to multiple sclerosis (MS).

Hyperbaric oxygen therapy is still regarded as quackery by many doctors because it is not taught in our medical schools he says. But it is simply a means of giving more of the oxygen we all breathe. We need to use more oxygen in medical practice and especially in the treatment of brain disorders, which remains in the dark ages.

There is now overwhelming evidence from advanced imaging of brain injured patients that confirms the brain cells may not be dead but sleeping or dormant, rather, and can be revived after injury.

A second important discovery is that stem cells that form in the brain as we grow in the womb are still present in our brains as adults and retain the ability to grow new nerve cells, Prof James adds.

His book, which charts our understanding of the importance of oxygen, takes in the adventures of 19th century balloonists, vital work on the nature of gases by the Scottish physiologist J.S. Haldane, the pre-war popularity of compressed air baths, and the opening in Cleveland in 1928 of the renowned hyperbaric hotel for patients with a variety of conditions.

Prof Philip James, author of the book Oxygen and the Brain

Oxygen, he points out, is a key component of the natural healing process, although we seldom think of it that way. The oxygen we breathe normally is involved in repairing and regenerating tissue all the time he explains.

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The miraculous healing powers of oxygen

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Tampa stem cell clinic is long on promises, not evidence

Posted: January 31, 2015 at 11:44 pm

TAMPA Dr. Burton Feinerman has spent more than a decade using stem cell therapies that are banned in the United States, sending desperate families to Peru seeking treatments for their babies' terminal conditions like Tay-Sachs disease.

The therapies are costly and unproven, and no insurer will cover them. But there is no law against a U.S. doctor recommending them, as long as they aren't performed here.

Now the 85-year-old pediatrician is focusing on a stem cell therapy he can perform in Tampa, for seniors with such incurable lung conditions as chronic obstructive pulmonary disease, or COPD.

Feinerman, medical director of the Tampa-based Lung Institute, says lung patients tend to get the most benefit from stem cell therapies. And he can treat them in the United States because he is re-infusing patients with their own stem cells, a legal process under certain circumstances.

But it's not approved as a lung disease therapy in this country. Neither the American Lung Association nor the International Society for Stem Cell Research have endorsed it. Medicare won't cover it.

So Feinerman's patients must pay cash between $7,500 and $12,000 for a three-day treatment, plus $4,500 for additional "boosters'' of cells extracted from their blood or abdominal fat.

The Lung Institute has produced a slick website and an advertising campaign, and it puts on seminars at which prospects can hear the testimonials of satisfied patients.

But there are no clinical data showing stem cell therapies benefit patients with lung disease, said Dr. Daniel Weiss, a professor at the University of Vermont College of Medicine and a leading lung disease researcher. Further, studies of mice suggest that if the therapies work, it likely would help only acute lung conditions like respiratory distress syndrome, not chronic conditions like COPD.

"I do not recommend any type of cell therapy (for lung disease) at this point," Weiss said.

Feinerman insists the doubters are wrong. "Just go to Google," he told a Times reporter who asked him for clinical research to back his claims. Lung Institute employees later provided citations for three journal articles, but none showed the treatments worked. In fact, Weiss wrote two of the articles.

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Tampa stem cell clinic is long on promises, not evidence

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cgi animation – Stem cell science takes a new leap in India – Video

Posted: January 31, 2015 at 11:40 pm

cgi animation - Stem cell science takes a new leap in India
Medical 3d animation explaining how the stem cells are harvested and how it can help future generations. we worked on the 3d animation part, was a cool project!!!! Presenting Babycell - The...

By: Lycodon FX

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cgi animation - Stem cell science takes a new leap in India - Video

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Sleep apnea surgery using Stem Cells week1 post-op – Video

Posted: January 31, 2015 at 11:40 pm

Sleep apnea surgery using Stem Cells week1 post-op
The healing process after stem cells implanted.

By: darrell cee

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Sleep apnea surgery using Stem Cells week1 post-op - Video