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Knee problems and stem cell therapy – Video

Posted: January 30, 2015 at 9:40 pm

Knee problems and stem cell therapy
Dr. Scott Greenberg discusses stem cell procedures for the knee and his experience with athletes, torn meniscus issues, and arthritis.

By: scott greenberg

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Knee problems and stem cell therapy - Video

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13 ABC: Advancements in stem cell therapy – 1/27/15 – Video

Posted: January 30, 2015 at 9:40 pm

13 ABC: Advancements in stem cell therapy - 1/27/15
ProMedica Physician Roger Kruse, MD, discusses use of stem cell therapy in orthopedic care.

By: ProMedica In The News

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13 ABC: Advancements in stem cell therapy - 1/27/15 - Video

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Gordie Howe's stem cell therapy raises concerns among medical experts

Posted: January 30, 2015 at 9:40 pm

Sheryl Ubelacker, The Canadian Press Published Thursday, January 29, 2015 6:49AM EST

TORONTO -- Gordie Howe's son says the hockey legend's stroke symptoms have improved since his treatment with stem cells at a Mexican clinic in early December and he wants him to repeat the procedure.

But regenerative medicine experts say there's no scientific evidence such therapies work, and in some cases they can be seriously harmful or even deadly.

The 86-year-old Howe suffered two disabling strokes late last year. In December, the family took him to a Tijuana clinic where he received stem cell injections as part of a clinical trial being run under a licensing agreement with Stemedica Cell Technologies of San Diego, Calif.

The experimental treatment involved injecting neural stem cells into Howe's spinal canal, along with intravenous infusions of mesenchymal stem cells, which are found in bone marrow, fat and umbilical cord blood.

Marty Howe said his father can walk again, his speech is improving and he is regaining some of the weight he lost following the strokes.

"After his stem cell treatment, the doctor told us it was kind of an awakening of the body, and it was all that," he told The Canadian Press while in Calgary for a hockey promotion event Tuesday. "They call it the miracle of stem cells and it was nothing less than a miracle."

However, experts in the field question whether stem cells are responsible for Howe's improvement and caution that most so-called stem cell therapies have not gone through rigorous scientific trials, nor have they been approved as treatments by Health Canada or the U.S. Food and Drug Administration.

Mick Bhatia, director of McMaster University's Stem Cell and Cancer Research Institute, said there are many unknowns in Howe's case, such as how many stem cells were administered, were tests done to see whether they migrated to the targeted area of the body, and did they take up residence where they might have some effect or simply disappear?

"Is this a transient effect, or is it really a perceived or somewhat of a placebo effect and is there something really happening? Scientifically and biologically that is important," Bhatia said Wednesday from Hamilton.

Trial to test stem cells in MS patients

Posted: January 30, 2015 at 9:40 pm

By Sheryl Ubelacker, The Canadian Press

TORONTO - Two Canadian research centres are gearing up for a clinical trial to determine if a type of stem cell can help alleviate the symptoms of multiple sclerosis.

Researchers at the Ottawa Hospital and Winnipeg's Health Sciences Centre will each recruit 20 MS patients for the trial that will test whether mesenchymal stem cells can reduce inflammation and even help repair damage already caused by the disease.

MS is thought to be an autoimmune disease that creates inflammation in the central nervous system, resulting in injury to myelin, the protective sheath that covers nerves. This damage can create a host of symptoms, leading to varying degrees of physical disability and cognitive impairment.

Mesenchymal stem cells, which are found in bone marrow, fat, skin tissue and umbilical cord blood, have the ability to modify the immune system and reduce inflammation, said neurologist Dr. Mark Freedman of the Ottawa Hospital Research Institute, who is leading the clinical trial.

Freedman said researchers want to determine if these stem cells can demonstrate anti-inflammatory properties in patients with MS.

"But that's not why we're doing it," he said of the study, called MESCAMS ("MEsenchymal Stem cell therapy for CAnadian MS patients"). "We have lots of drugs that can control inflammation in multiple sclerosis that's what all the new medicines do."

"The ultimate hope is that we will be able to exploit some of their other very important biological properties, which is to promote repair."

The two research centres are ready to begin enrolling patients for the trial, which has specific acceptance criteria. While most of those accepted will likely have the relapsing-remitting form of the disease, Freedman said some people with more severe primary- or secondary-progressive MS may also be eligible if they fit the criteria.

The study protocol can be accessed at http://www.clinicaltrials.gov/show/NCT02239393. It will later be posted on the website of the MS Society of Canada, which along with the Multiple Sclerosis Scientific Research Foundation has provided a $4.2-million grant for the study.

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Trial to test stem cells in MS patients

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