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Stem Cell Treatment for Epilepsy | eHow

Posted: December 12, 2014 at 1:05 pm

Ann Murray

Ann Murray has been writing since 1990, with her work now appearing on various websites. She holds a Bachelor of Arts in writing and history from Bard College and is pursuing her Doctor of Philosophy in biology.

Epilepsy is a brain disorder involving repeated and spontaneous seizures. Epilepsy is also called seizure disorder. A seizure occurs when a surge of electrical activity affects part of the brain. Seizures can have many symptoms and can last from a few seconds to several minutes. They are typically characterized by a loss of consciousness and convulsions. Embryonic stem cells can contribute to brain tissue regeneration and can reduce the frequency and severity of seizures, according to a study presented to the European Congress on Epileptology in Vienna, Austria.

Stem Cell Treatment for Epilepsy. Epilepsy is a brain disorder involving repeated and spontaneous seizures. Epilepsy is also called seizure disorder.

Brain stem tumors, ... Benign tumors don't include cancerous cells, ... These seizures are often followed by a day's worth of nausea...

Now that Pres. Obama has revoked the Bush administration's restrictions on federal funding of embryonic stem cell research, patients everywhere are wondering...

Stem Cell Treatment for Epilepsy. Epilepsy is a brain disorder involving repeated and spontaneous seizures. Epilepsy is also called seizure disorder.

Medical science has held that when lung tissue dies, it cannot be replaced. But now it just might be regenerated, according to...

Though all seizures are caused by abnormal activity in the brain, not all seizures are related to epilepsy. In addition, one particular...

Epilepsy is a disorder that has a range of intensities. Refractory seizures are a symptom of a certain type of epilepsy called...

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Stem Cell Malaysia Blog

Posted: December 12, 2014 at 1:05 pm

Updates from the recent annual scientific conference organised by the Society for Anti-Ageing, Aesthetics and Regenerative Medicine Malaysia.

THE Society for Anti-Ageing, Aesthetics and Regenerative Medicine Malaysia (SAAARMM) had its annual scientific conference recently, and I would like to share some of the updates.

You will notice that the society has a long name. It started as just an anti-ageing society. Then aesthetics was added because the demand for aesthetic therapies actually exceeds that of anti-ageing therapies. While most people want to look young, not all of them are concerned about being young (ie healthy). Finally, regenerative medicine was added.

Anti-ageing medicine implies the slowing down or reversal of ageing in an otherwise healthy person, while regenerative medicine implies the restoration of health and functions in the unhealthy or diseased person. Once health is restored, any further gain would be anti-ageing. These are strategies applied at different points of the health spectrum.

I try not to miss the annual convention because I always get to meet two of the pioneers and leading researchers/proponents in this field. Both are from the US.

Dr Bob Goldman is the chairman and co-founder of the American Academy of Anti-Aging Medicine (A4M), which is hugely responsible for popularising and promoting anti-ageing medicine throughout the world. He also holds the world record for hand-stand push-ups (doing push-ups with the body vertically up, head down).

Dr Nick Delgado is one of my mentors. He worked with the famous Pritikin Longevity Centre and also with top performance coach Anthony Robbins. Among other things, he taught me the goodness of whole-food juicing. He has his own range of supplements and anti-ageing strategy The Delgado Protocol. At the age of 54, he is the world champion for vertical lifts (repetitive lifting of 25-pound weights on alternate arms) and continues to defend his title. He is also pioneering the use of stem cells for rejuvenation, and uses himself as a guinea-pig, getting the injections every month. Already he has more hair than last year. He hopes to live to 150!

The three of us are of the same age (so is Dr Ronald Klatz, President and co-founder of A4M). So it will be interesting to see how we age over the years. All three of us rely on hormone optimisation/balancing and nutritional supplements. They are super-fit and super-strong individuals, while I only go to the gym whenever possible. I have to rely on my qigong to keep up with them. And soon I will have to start injecting stem cells into myself too.

Rejuvenation strategies

The basis of health and rejuvenation has always been a healthy lifestyle, a nutritious diet, and adequate exercise. And may I add, enough life-force, or qi. Every other strategy is additional to these basic requirements.

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Stem Cell Malaysia Blog

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Seeing Is Believing

Posted: December 12, 2014 at 1:05 pm

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Newswise If seeing is believing, C.K. Choi has a passion for clarityin a very tiny world. The assistant professor of mechanical engineering's research lies at the micro-scale, in channels no thicker than a strand of hair.

Chois first visualization breakthrough came more than 10 years ago when his team, for the first time in the world, used a confocal microscope to observe velocity fields in a micro-channel, in a space with a diameter smaller than a pin.

His next pioneering move was an innovative use of a technology Choi describes as beautiful, the Total Internal Reflection Fluorescence Microscope. He integrated this system with other optical devices to help researchers literally see in the dark, creating fluorescent images clear enough to examine nanoparticles and proteins near the surface.

Choi sought practical applications for his optical devices and found them in biomedical engineering. Researchers were using electrical measurements to analyze physiological changes of cells inside blood vessels, but needed an optical way to verify the data. He proposed using indium tin oxide (ITO), a common coating used in modern electronics. His hunch worked: the ITO biosensor offered the perfect marriage of optical transparency and electrical conductivity, allowing both electrical measurements and visual observation simultaneously.

The ITO biosensor led to other inter-disciplinary workand a lot more questions. In the human body, cells are subjected to different environments: lung cells to the flow of oxygen, heart cells to pulses of blood, brain cells to electrical charges, etc. Given these radically different environments, Choi asked himself, If I grow cells outside their normal living conditions, will they really be the same type of cells? If companies test their drugs on cells grown here [in the static environment of the lab], will their results be accurate?

He knew that he couldnt mimic all the bodys natural conditions, but he could at least create a device that allowed medical researchers to examine their cell lines under appropriate flow conditions.

Actually very low flow conditions, as is the case with lung cells. In his search for a device that could create ultra-low flows, Choi realized that neither direct current (DC) nor syringe pumps could be used: most mechanical pumps cannot produce consistent flow in micro-channels, and DC can physiologically affect the cells being studied. Exposure to DC can alter the metabolism and nutrients, especially problematic for stem cells which are highly sensitive to environmental changes.

Choi and his collaborators proposed using diodes, which are cheap, reliable components, to drive the current in their electro-osmosis diode pumping device (EOS). It worked. The EOS creates low, consistent flows in a way that does not affect cell growth and contains optical elements to visually track the fluorescent particles.

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Seeing Is Believing

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Exploring Stem Cell Therapy for Cerebral Palsy | See the Seitz

Posted: December 12, 2014 at 1:03 pm

When Hudsyn was first given the label cerebral palsy, Dan and I sat in that tiny doctors office and listened as the neurologist explained what the medical term actually meant. We nodded our heads partially in disbelief, yet also having a large amount of relief that we finally had a diagnosis.

The tough part came when he began talking about what we do next. Some part of me was really hopeful. Surely because this diagnosis is so common, there are a variety of things we can do to help our little girl live a full life. But after hearing the statements, We cannot repair brain damagethere is no cure for this outcome. So what we do now is treat symptoms and make her as comfortable and happy as possible by encouraging the healthy cells she has left to work hard and operate at maximum potential.

I felt like Id been punched in the stomach.

No cure? No way we can repair her brain to go back to what God had created for her in my womb? This wasnt supposed to be the way it ended. Give me the path, docanything. Ill do anything to help her get better. Will it take thousands of dollars to get a treatment that Id have to go to China to receive? Ill do it. But saying theres nothing you can dosome part of me refused to accept that. And Im very grateful I didnt. Because with hope and determination comes solutions.

We began prayinga lot. Then I began to researchanything I could get my hands on to help understand CP and what our life was going to be like in the future. It hurt because some of it was unbelievably difficult to imagine. I asked other parents. I found treatments like Cuevas Medek Exercise therapy, Hyperbaric Oxygen Therapy (HBOT), and a host of alternative treatments which I wrote about last May. But none of these proved to improve her condition significantly on their own.

And then, a glimmer of hope surfaceda mom on one of my support groups pointed me to a hospital in Panama City that was doing something called Stem Cell Therapy for kids with brain damageespecially those with the diagnosis of Cerebral Palsy. So I dug a little deeper and found videos like these:

Obviously, I was skeptical and so was Dan. I think his first statement after hearing that I was suggesting we take our daughter to Panama City to get stem cell injections was, Im sorry honey, but theres no way in hell were doing that.

I continued to research despite his skepticism and mine. I wanted to know more facts. Maybe we couldnt do it right now, but I wondered if this was a future possibility for her once it was approved in the U.S.

Cord banks in the U.S. are talking about itabout their healing and regenerative potential. As the master cells of the body, stem cells are the building blocks of blood, tissue, and organs. Cord blood stem cells are being used today to treat serious diseases like leukemia and sickle cell anemia. Theyre also being researched as treatment for conditions like cerebral palsy, traumatic brain injury (TBI), and hearing loss in clinical trials and lab research.

I continued my thirst of information by reading several books, articles, case studies and medical journals. I watched even more videos, presentations, listened to podcasts and audio recordings anything I could get my hands on to learn more about this type of therapy, but especially if it applied to kids and those with cerebral palsy. Below is a summary of the biggest points I pulled out of each resource:

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Exploring Stem Cell Therapy for Cerebral Palsy | See the Seitz

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Stem Cell Therapy For Autism In USA – World Stem Cells, LLC

Posted: December 12, 2014 at 1:02 pm

Autism Spectrum Disorder (ASD) Characteristics

Autism spectrum disorder (ASD) includes individuals with a range of symptoms, abilities, and levels of impairment. Some children with autism are very high-functioning, communicating with others and performing well at school, while others experience significant impairment and remain highly dependent on caregivers.

Symptoms

Exact traits may vary by child, but autism is characterized by the following symptoms:

Social impairment. Kids with autism tend to make less eye contact, fail to respond to people in their environment, avoid sharing enthusiasm about activities by pointing or showing toys to others, and have atypical responses to others emotions. They often fail to reciprocate others emotions and avoid interacting socially with peers or adults.

Communication difficulties. For many children with autism, communication abilities remain a challenge. Early signs of autism include failure to develop age-appropriate gestures (e.g., pointing or waving), slowness in responding to their name, and a sudden stop in babbling after age one. Children show general language delays, having difficulty using complete sentences, substituting special made-up words in conversation, or repeating the same phrase over and over.

Repetitive behaviors. One of the hallmark symptoms of autism spectrum disorder is repetitive behaviors. This might include hand flapping, rocking, or finger flicking. Some children with autism may develop highly focused interests that have an obsessive quality. For example, some kids feel driven to learn as much as possible about trains, dinosaurs, or Star Trek. Interrupting these preoccupations, such as moving a favorite toy train, can be extremely upsetting for a child with autism.

Neurological and Physiological Changes

Researchers continue to explore the neurobiological changes associated with ASD. MRI studies have found that children with autism have some brain areas that are larger than neurotypical children, while other brain areas are smaller. During development, abnormal neuronal growth and problems with pruning of growing neurons may contribute to these differences.

Specifically, many children with autism have changes in the temporal lobe. This lobe is important for language processing, attention, empathy, facial processing, and social abilities. Changes in the structure and function of the temporal lobe may underlie autistic kids difficulties connecting socially, showing appropriate emotions, and communicating with others.

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Bone Marrow and Stem Cell Transplant UF Health Cancer …

Posted: December 12, 2014 at 1:02 pm

Bloodand Marrow Transplant Program (352)733-0972

The Blood and Marrow Transplant Program at UF Health is comprised of a specialized, comprehensive team that is available to assist you with your care throughout your transplant experience. The Program began in 1981 and is the states longest established transplant program. We have performed more than 2000 transplants for both adults and pediatrics for diseases such as leukemia, multiple myeloma, lymphomas, neuroblastoma, myelodysplastic syndromes, testicular cancer, aplastic anemia, certain genetic disorders and immunodeficiency syndromes.

The Blood and Marrow Transplant Program is part of the UF Health Cancer Center, an interdisciplinary initiative connecting clinicians and scientists who perform original scientific research as well as conduct research protocols to enhance strategies for the diagnoses, treatment and prevention of cancer. You may be invited to participate in clinical trials which offer new tests or treatments that are appropriate for your disease.

Our multidisciplinary treatment team consists of experienced University of Florida transplant physicians, RN transplant coordinators, physician assistants, registered nurses, social workers, pharmacists, and support staff. Our interdisciplinary team meets weekly to carefully review patient information and develop the best possible treatment plan for each individual. Our team works together to provide a comprehensive evaluation and determine the best course of treatment available. To augment the services of our multidisciplinary team, our patients benefit from numerous services including:

A pre-transplant evaluation with all tests done at Shands at UF usually takes three to five days to complete. You will undergo pre-BMT evaluation and counseling before you are admitted to the Shands at BMT unit. Your BMT evaluation typically consists of the following:

For more information, or to schedule an appointment, please call (352)733-0972

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Co-author of controversial acid STAP stem cell papers in …

Posted: December 12, 2014 at 1:01 pm

A co-author of two papers claiming to have shown how to create stem cells simply and easily has requested their retraction, the Wall Street Journal is reporting:

Teruhiko Wakayama of Yamanashi University in Japan, a co-author of both papers published in Nature, said he has asked the lead author of the papers, Haruko Obokata, to retract them.

There is no more credibility when there are such crucial mistakes, he said in an email to The Wall Street Journal. He didnt elaborate on what the mistakes were.

Nature told the WSJ that it was still investigating the matter. As Natures news section reported last month, lead author

biologist Haruko Obokata, who is based at the institutionshot to fame as the lead author of two papers1, 2 published in Nature last month that demonstrated a way to reprogram mature mouse cells into an embryonic state by simply applying stress, such as exposure to acid conditions or physical pressure on cell membranes.

But the studies, published online on January 29, soon came under fire. Paul Knoepfler has had a number of detailed posts on the matter, as has PubPeer.

The controversy is the latest for the field of stem cells, both embryonic and adult. Among other cases:

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FlGraft Therapy | Arizona Pain Stem Cell Institute

Posted: December 12, 2014 at 1:00 pm

History

During pregnancy, a fetus is surrounded a fluid, known as amniotic fluid, that serves to both protect the fetus and aid in its growth. Amniotic fluid has been used in medical treatments as far back as the 1930s.1

Doctors discovered that amniotic fluid was beneficial in treatments such as the healing of wounds. Over time, this treatment has been developed thanks to advancements in the ability to screen donors and amniotic fluid for safety, as well as the ability to safely preserve these tissues at very low temperatures until they are ready for use.

FlGraftTM Therapy is an Applied BiologicsTM tissue product obtained from healthy donors during planned caesarian births. Donors are carefully screened on the basis of medical history, blood tests and tests of communicable diseases. Amniotic tissues are then collected at birth without harm to the mother or baby. These tissues are screened for safety and preserved in a tissue bank until they are needed for treatment. Patients receiving FLOW TherapyTM undergo an injection derived from amniotic fluid into the body part being treated.

We are offering FlGraftTM Therapy at a subsidized rate through research studies. One study will assess the efficacy of this treatment in alleviating the pain caused by degeneration of joints in the lower back. Another study will measure the efficacy of FlGraftTM Therapy for treating degeneration of joints of the upper and lower extremities (e.g., shoulders, elbows, hips, knees). Patients qualifying for one of these studies will receive a substantial reduction in the treatment price, as Applied Biologics and the Arizona Pain Stem Cell Institute are subsidizing the price for the purpose of the study. Patients pain scores, activities of daily living, and medication usage will be assessed both before treatment and over the six months after treatment.

FlGraftTM Therapy uses tissues that have been thoroughly tested according to standards that exceed those required by regulatory agencies to insure their safety. Additionally, the immune privileged nature of amniotic fluid makes these tissues safe for injection. However, like any injection therapy, there are risks associated with the injection, including irritation or pain at the injection site or possibly infection. Discuss these with your health care provider prior to getting this procedure.

Because many patients painful conditions are adequately addressed by conservative treatments, we recommend that patients pursue this treatment only if they continue to experience moderate to extreme pain after trying conservative treatments such as rest, physical therapy and non-steroidal anti-inflammatory drugs (e.g., ibuprofen).

Doctors have had success with FlGraftTM Therapy in closing chronic wounds and healing damage to tissues such as muscles, tendons and joints. After receiving FlGraftTM Therapy, healing will take between several weeks and a few months to notice the results. Many patients get healing and pain relief after a single injection. However, based on an individual patients condition and symptoms and their doctors assessment, additional injections may be advised. Further, as with any treatment for pain, not every patient will have success with this treatment.

1. Shimberg M. The use of amniotic fluid concentrate in orthopaedic conditions. J Bone Joint Surg Am 1938;20:167-177.

2. Aagaard-Tillery KM, Silver R, Dalton J. Immunology of normal pregnancy. Semin Fetal Neonatal Med 2006 Oct;11(5):279-95.

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Enrollment in the Cord Blood and Cord Tissue Stem Cell …

Posted: December 12, 2014 at 1:00 pm

Enrolling in Cryo-Cell's Cord Blood and Cord TissueStem Cell Service is easy!

Alternative ways to Enroll

1Fee schedule subject to change without notice. If a client has received a kit anddiscontinues services prior to collection, a $150 non-refundable discontinuation fee applies.Add $50 for medical courier service from Alaska, Hawaii and Puerto Rico. Subtract $50 for medical courier service from Tampa Bay, Florida area. Applies to 1-year plan only. After the first year, an annual storage fee will apply. If in-house financing is provided; first payment will be billed upon enrollment.

In order to preserve more types and quantity of umbilical cord stem cells and to maximize possible future health options, Cryo-Cells umbilical cord tissue service provides expectant families with the opportunity to cryogenically store their newborns umbilical cord tissue cells contained within substantially intact cord tissue. Should umbilical cord tissue cells be considered for potential utilization in a future therapeutic application, further laboratory processing may be necessary. Regarding umbilical cord tissue, all private blood banks activities for New York State residents are limited to collection, processing, and long-term storage of umbilical cord tissue stem cells. The possession of a New York State license for such collection, processing and long-term storage does not indicate approval or endorsement of possible future uses or future suitability of these cells.

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Canadian-led team of researchers shows how stem cells can be reprogrammed

Posted: December 11, 2014 at 7:53 pm

TORONTO A Canadian-led international team of researchers has begun solving the mystery of just how a specialized cell taken from a persons skin is reprogrammed into an embryonic-like stem cell, from which virtually any other cell type in the body can be generated.

The research is being touted as a breakthrough in regenerative medicine that will allow scientists to one day harness stem cells to treat or even cure a host of conditions, from blindness and Parkinsons disease to diabetes and spinal cord injuries.

Besides creating the reprogramming roadmap, the scientists also identified a new type of stem cell, called an F-class stem cell due to its fuzzy appearance. Their work is detailed in five papers published Wednesday in the prestigious journals Nature and Nature Communications.

Dr. Andras Nagy, a senior scientist at Mount Sinai Hospital in Toronto, led the team of 50 researchers from Canada, the Netherlands, South Korea and Australia, which spent four years analyzing and cataloguing the day-by-day process that occurs in stem cell reprogramming.

The work builds on the 2006-2007 papers by Shinya Yamanaka, who showed that adult skin cells could be turned into embryonic-like, or pluripotent, stem cells through genetic manipulation, a discovery that garnered the Japanese scientist the Nobel Prize in 2012.

Nagy likened the roughly 21-day process to complete that transformation to a black box, so called because scientists did not know what went on within the cells as they morphed from one cell type into the other.

It was just like a black box, Nagy said Wednesday, following a briefing at the hospital. You start with a skin cell, you arrive at a stem cell but we had no idea what was happening inside the cell.

Nagys team set about cataloguing the changes as they occurred by removing cells from culture dishes at set points during the three-week period, then analyzing such cellular material as DNA and proteins present at that moment.

The result is a database that will be available to scientists around the world, which the team hopes will spur new research to advance the field of stem cell-based regenerative medicine.

Co-author Ian Rogers, a scientist in Nagys lab, said the database will allow researchers to identify various properties of the developing stem cells, which could mean improving their ability to treat or cure disease.

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