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Why people with diabetes have more UTIs and how to prevent infections – Medical News Today

Posted: October 4, 2022 at 2:21 am

Infections, especially urinary tract infections (UTIs), are common experiences for people with diabetes. UTIs are also often more severe in people with diabetes than they are in those without diabetes. UTIs may lead to serious kidney problems in those with diabetes, such as renal abscesses, emphysematous cystitis and pyelonephritis, and renal papillary necrosis.

In type 1 diabetes, the pancreas stops producing insulin that regulates blood glucose levels. In type 2, cells become less sensitive to insulin. With both types, excessive glucose levels in the blood can reduce the effectiveness of ones immune system.

Dr. Jason Ng of the University of Pittsburgh Medical Center, not involved in the study, explained to Medical News Today, The higher sugars create a series of impaired defense mechanisms which people use to protect against UTIs.

Now, a study from researchers at Swedens Karolinska Institutet investigates the mechanism behind glucoses effect.

The study finds that high glucose levels in diabetes reduce levels of one of the bodys natural antibiotics, the antimicrobial peptide psoriasin, an important barrier against infection.

Urologist Dr. S. Adam Ramin, also not involved in the research, described the usual role of psoriasin to MNT:

Its known that this particular protein is an initial line of defense against certain bacterial infections. And now, based on this study, it appears that this particular protein is downregulated meaning that it is not made at as high a concentration as in people who dont have diabetes and therefore may be one of the pathways that makes diabetic patients more susceptible to infections.

We have observed that patients with diabetes have [a] higher risk of UTIs, said Dr. Ng. So this process could further elucidate why this observation exists.

The researchers analyzed urine, urinary bladder cells, and blood serum samples from adult volunteers who were non-diabetic or who had prediabetes or diabetes. The study did not include people with current UTI diagnoses.

The analysis revealed that participants with prediabetes or diabetes had reduced levels of psoriasin.

The researchers confirmed the findings in follow-up studies using mice with type 2 diabetes and human uroepithelial cell lines.

Study principal investigator, Prof. Annelie Brauner, tells Karolinska Institutet News that such reduced levels weakens the cells protective barrier function and increases the risk of bladder infection.

Dr. Ramin explained:

Essentially, this is a protein that inhibits the binding of bacteria to epithelial cells and endothelial cells, and if these bacteria cannot bind to the epithelial cells of the bladder, then they may not grow. They will be inhibited from growth, and therefore they cant propagate inside the bladder.

When bacteria propagate, thats when infection occurs because essentially infection is an overgrowth of bacteria within an organ like the bladder, as opposed to a situation in which psoriasin would be inhibiting the growth of the bacteria.

Prof. Brauner also pointed out an interesting finding.

We found that high glucose concentrations reduce the levels of the antimicrobial peptide psoriasin, while insulin has no effect [on psoriasin levels], she said.

Previous research by Prof. Brauners group found that estrogen helps restore the protective function of bladder cells. The new study confirms that estrogen can restore psoriasin levels.

Dr. Ramin said the current studys results are consistent with earlier findings on postmenopausal women with low estrogen who are at a higher risk of developing UTIs. He said the recurrence of UTIs significantly decreased among women after using prescription estrogen vaginal creams, and this was a pathway to learning that estrogen can help prevent UTIs.

Dr. Ramin said the topical treatment is generally safe for most women.

Topical estrogen or estrogen creams in the vagina do not get absorbed systemically, so were not concerned about causing cancer or any other issues, he said. In fact, many women who have had gynecologic cancers in the past, and they have been cured, are still eligible to get estrogen vaginal cream.

Prof. Brauner also noted:

All medical treatment must be given with caution. Estrogen given locally (in the vagina) is a common treatment in postmenopausal women, and very few side effects have been observed. However, estrogen should not be given orally due to possible adverse effects and since oral administration has no proven effect in the treatment of UTI.

Prof. Brauner added that experts do not recommend treating men with estrogen.

Dr. Ng also expressed caution:

Without further research, I would not promote estrogen use to reduce the risk of UTIs via promoting psoriasin levels. We have to be careful since estrogen medications have significant side effects as well.

Well-controlled diabetes is important to prevent infections as well as other complications, said Prof. Brauner. It is of course not always easy to keep low-to-normal blood glucose levels.

Dr. Ng said the best way to prevent UTIs in patients with diabetes is to practice good hygiene habits and improve sugar control as much as possible.

Dr. Ramin offered some tips that can help people avoid UTIs:

We know that patients who are constipated, theyll get translocation of bacteria from their rectum into the bladder or from the large intestine to the bladder, so its important to avoid constipation, Dr. Ramin explained.

Women who are sexually active should exercise good hygiene, meaning that after sexual activity it is important for them to go to the bathroom and urinate relatively quickly, he added. Its important to keep good vaginal health, and keep that area clean.

Dr. Ramin also noted that some people can benefit from taking or drinking pure cranberry juice because the acid level may kill bacteria and prevent bacterial formation.

In the future, we hope to be able to target ways to locally increase psoriasin in the urinary bladders. We hope and believe that this could have positive effects on the prevention of infections in the bladder, Prof. Brauner concluded.

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NOACs or Warfarin in Atrial Fibrillation With Diabetes – DocWire News

Posted: October 4, 2022 at 2:21 am

In a recent meta-analysis, researchers found that new direct oral anticoagulants (NOACs) demonstrated lower rates of stroke or systemic embolism (SSE), ischemic stroke, and hemorrhagic stroke in patients with nonvalvular atrial fibrillation (NVAF) and diabetes mellitus compared with warfarin. Additionally, NOACs did not significantly increase the risk of major bleeding. The results were published in the Journal of Translational Medicine.

The researchers assessed 5 retrospective studies and 4 subgroup analyses of randomized controlled trials from the PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases. The pooled cohort included 267,272 patients.

According to the authors, NOACs significantly reduced SSE risk compared with warfarin (pooled hazard ratio [HR], 0.80; 95% CI, 0.74-0.85) in both types of studies. NOACs also appeared to reduce major bleeding risk for patients with atrial fibrillation and diabetes mellitus (pooled HR, 0.85; 95% CI, 0.73-0.99), though the authors noted there was significant heterogeneity among the included studies.

Additionally, the researchers found differences between NOACs and warfarin in risk for the following outcomes:

Despite limitations, including not assessing additional diabetes mellitus biomarkers, as well as potential biases across the included studies, the authors ultimately suggested NOACs may be a better choice for anticoagulation in patients with NVAF and diabetes.

Find Related Articles and Interviews at the Atrial Fibrillation Knowledge Hub

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Why Type 1 Diabetes Is Tougher on Girls Than Boys – Healthline

Posted: October 4, 2022 at 2:21 am

New research reports that type 1 diabetes may be tougher on girls than boys due to higher blood sugar levels, weight issues, and higher cholesterol.

Girls may also deal with higher rates of depression and have lower overall scores gauging quality of life.

The review of 90 previous studies done by researchers at Amsterdam University Medical Centers stated there are some consistent patterns in how type 1 diabetes affects girls and boys differently.

The findings were presented at the annual meeting of the European Association for the Study of Diabetes in Stockholm.

The review has not been published yet in a peer-reviewed journal.

In their review, the researchers reported, girls showed higher A1C levels a measure of blood sugar control over the previous three months than boys. Girls also had a higher rate of obesity and high cholesterol, along with lower scores on the quality of life surveys.

Type 1 diabetes usually occurs in childhood and affects more than 1.45 million people in the United States

It involves a persons immune system mistakenly attacking pancreatic cells that produce insulin a hormone responsible for moving food sugar into body cells for energy. Without insulin, sugar builds up in the blood, starving body cells. That requires people with type 1 diabetes to take synthetic insulin.

In terms of this research about type 1 diabetes being tougher on girls than boys, when it comes to weight gain and blood sugar levels, this information is new to the medical community, but its not necessarily surprising Dr. Abiona Redwood, an instructor in the Family Medicine residency Program at Community Health of South Florida, told Healthline. Thats because when it comes to weight gain, girls and women experience three periods of weight gain: puberty, which the report touched on, pregnancy, and menopause. Its a lot harder for girls and women to lose weight when they go through those things.

Just imagine adding to that type 1 diabetes and the different hormonal changes caused by menstruation that can also have an effect and happens 12 times a year for girls and women with ordinary period cycles, Redwood added. Girls also arrive at puberty two years before boys do, and as early as age eight.

Girls, especially during puberty, experience frequent hormonal changes, whereas with boys, hormonal changes tend to be gradual, and they dont experience these monthly changes, Redwood noted. A lot of this is physical, especially when the hormonal changes affect blood sugar. The up-and-down hormonal movements are going to prove a significant factor when it comes to weight gain.

Also, historically, girls have had greater issues about body image, she added. What I have seen among my patients, is that as girls with type 1 diabetes enter their teens the pressures of family and social obligations can make them prone to neglecting their diabetes treatment. Too often parents assume, as their girls enter their teens, they will be more responsible about their diabetes, but quite often its the opposite and this is precisely the time when these girls need extra parental support when it comes to maintaining medication discipline. This is a time of increasing and competing concerns for these girls, after all.

Dana Ellis Hunnes a senior clinical dietitian at UCLA Medical Center and assistant professor at UCLA Fielding School of Public Health, told Healthline that women and girls have typically not received as much attention as study subjects as men.

That could explain why girls having more difficulty with type 1 diabetes is only now coming to light.

I believe there are more pressures on girls, even at a younger age, to appear in certain ways or behave in certain ways, Hunnes said. There is, of course, also the biological component, girls according to this study had higher BMI at diagnosis and poorer glucose control so some of that may be biological insulin/hormone production -and some of it may be psychological.

Girls may have earlier onset of beta-cell destruction the cells that secrete insulin than boys do, which is why they are diagnosed at a younger age, she added. It may also be that they live with the condition longer before diagnosis and so that could leave them with higher blood sugar levels. It may also be psychological in the sense that girls may want to fit in more at a younger age than boys and so, may be more willing to assimilate their eating habits to the crowd.

Dr. Eva Shelton, a physician at Brigham and Womens Hospital in Seattle, told Healthline there could also be a body composition issue.

Women tend to have more adipose tissue (used for fat storage) as opposed to lean muscle, compared to men, Shelton said. Women are also more likely to eat as a coping mechanism than boys. The increase in adipose tissue and lipid content in women predisposes to insulin resistance, and that combined with uncontrolled snack eating leads to high blood sugars and more severe diabetes.

Dr. Robin Dickinson is a family practitioner in Englewood, Colorado. Shes also the founder of Dr. Robins School, a human biology program for children in third to eighth grade.

Dickinson told Healthline that teaching kids about type 1 diabetes stands out to her, and not just because she pokes her finger with a lancet to demonstrate how kids check their blood sugar.

More than any other condition, the kids with diabetes are constantly receiving messages from people around them teachers, friends parents, other kids about what they should and should not be doing, Dickinson said. Kids with diabetes, especially girls, are often told that they shouldnt eat particular foods or shouldnt be exercising or should worry about their blood sugar or weight by anyone who knows they are diabetic or sees them checking their sugars.

Dickinson said its important not to alienate children who do develop diabetes.

As in so many other areas, girls come in for more of this, Dickinson said. People worry more, try to limit their physical activity more, try to limit their eating more. Yes, they need to watch their sugars, but that isnt everyones business. The best way to be a friend to a girl with diabetes is to treat them like a normal kid and not invade their privacy with lots of shoulds and shouldnts.

Hunnes added that the research shows doctors should treat girls with type I diabetes differently than boys.

We know from adults that women experience heart attacks differently than men do and, as such, should be treated differently, as far as determining the diagnosis, she said. We know that women have menstrual cycles each month (on average) that can affect hormones all over their body, and as such, may need different varieties of treatment than boys, psychologically, and possibly medically/biologically as well.

If there are psychological components to higher blood sugars, then I also think it is important for the doctor to understand what is happening there as well. Medicine cannot be one-size-fits-all, Hunnes added.

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Improve Diagnosis of Type of Heart Failure Common in Diabetes – Medscape

Posted: October 4, 2022 at 2:21 am

STOCKHOLM Recent study results confirm that two agents from the sodium-glucose cotransporter 2 (SGLT2) inhibitor class can significantly cut the incidence of adverse cardiovascular events in patients with heart failure with reduced ejection fraction (HFpEF), a disease especially common in people with type 2 diabetes, obesity, or both.

And findings from secondary analyses of the studies including one reported last week during the European Association for the Study of Diabetes (EASD) 2022 Annual Meeting show that these SGLT2 inhibitors work as well for cutting incident adverse events (cardiovascular death or worsening heart failure) in patients with HFpEF and diabetes as they do for people with normal blood glucose levels.

But delivering treatment with these proven agents, dapagliflozin (Farxiga) and empagliflozin (Jardiance), first requires diagnosis of HFpEF, a task that clinicians have historically fallen short in accomplishing.

When a year ago, results from the EMPEROR-Preserved trial with empagliflozin and when a few weeks ago results from the DELIVER trial with dapagliflozin established the efficacy of these two SGLT2 inhibitors as the first treatments proven to benefit patients with HFpEF, they also raised the stakes for clinicians to be much more diligent and systematic in evaluating people at high risk for developing HFpEF because of having type 2 diabetes or obesity, two of the most potent risk factors for this form of heart failure.

"Vigilance for HFpEF needs to increase because we can now help these patients," declared Lars H. Lund, MD, PhD, speaking at the meeting. "Type 2 diabetes dramatically increases the incidence of HFpEF," and the mechanisms by which it does this are "especially amenable to treatment with SGLT2 inhibitors," said Lund, a cardiologist and heart failure specialist at the Karolinska Institute, Stockholm.

HFpEF has a history of going undetected in people with type 2 diabetes, an ironic situation given its high incidence as well as the elevated rate of adverse cardiovascular events when heart failure occurs in patients withtype 2 diabetes compared with patients who do not have diabetes.

The key, say experts, is for clinicians to maintain a high index of suspicion for signs and symptoms of heart failure in people with type 2 diabetes and to regularly assess them, starting with just a few simple questions that probe for the presence of dyspnea, exertional fatigue, or both, an approach not widely employed up to now.

Clinicians who care for people with type 2 diabetes must become "alert to thinking about heart failure and alert to asking questions about signs and symptoms" that flag the presence of HFpEF, advised Naveed Sattar, MBChB, PhD, a professor of metabolic medicine at the University of Glasgow, United Kingdom.

Soon, medical groups will issue guidelines for appropriate assessment for the presence of HFpEF in people with type 2 diabetes, Sattar predicted in an interview.

"You can't simply ask patients with type 2 diabetes whether they have shortness of breath or exertional fatigue and stop there," because often their first response will be no.

"Commonly, patients will initially say they have no dyspnea, but when you probe further, you find symptoms," noted Mikhail N. Kosiborod, MD, co-director of Saint Luke's Cardiometabolic Center of Excellence in Kansas City, Missouri.

These people are often sedentary, so they frequently don't experience shortness of breath at baseline, Kosiborod said in an interview. In some cases, they may limit their activity because of their exertional intolerance.

Once a person's suggestive symptoms become known, the next step is to measure the serum level of N-terminal pro-B-type natriuretic peptide (NT-proBNP), a biomarker considered to be a generally reliable signal of existing heart failure when elevated.

Any value above 125 pg/mL is suggestive of prevalent heart failure and should lead to the next diagnostic step of echocardiography, Sattar said.

Elevated NT-proBNP has such good positive predictive value for identifying heart failure that it is tempting to use it broadly in people with type 2 diabetes. A consensus report from the American Diabetes Association that was published earlier this year says that "measurement of a natriuretic peptide [such as NT-proBNP] or high-sensitivity cardiac troponin is recommended on at least a yearly basis to identify the earliest HF [heart failure] stages and implement strategies to prevent transition to symptomatic HF."

But because of the relatively high current price for an NT-proBNP test, the cost-benefit ratio for widespread annual testing of all people with type 2 diabetes would be poor, some experts caution.

"Screening everyone may not be the right answer. Hundreds of millions of people worldwide" have type 2 diabetes. "You first need to target evaluation to people with symptoms," advised Kosiborod.

He also warned that a low NT-proBNP level does not always rule out HFpEF, especially among people with type 2 diabetes who also have overweight or obesity, because NT-proBNP levels can be "artificially low" in people with obesity.

Other potential aids to diagnosis are assessment scores that researchers have developed, such as the H2FPEF score, which relies on variables that include age, obesity, and the presence of atrial fibrillation and hypertension.

However, this score also requires an echocardiography examination, another test that would have a questionable cost-benefit ratio if performed widely for patients with type 2 diabetes without targeting, Kosiborod said.

A prespecified analysis of the DELIVER results that divided the study cohort on the basis of their glycemic status proved the efficacy of the SGLT2 inhibitor dapagliflozin for patients with HFpEF regardless of whether or not they had type 2 diabetes, prediabetes, or were normoglycemic at entry into the study, Silvio E. Inzucchi, MD, reported at the EASD meeting.

Treatment with dapagliflozin cut the incidence of the trial's primary outcome of cardiovascular death or worsening heart failure by a significant 18% relative to placebo among all enrolled patients.

The new analysis reported by Inzucchi showed that treatment was associated with a 23% relative risk reduction among those with normoglycemia, a 13% reduction among those with prediabetes, and a 19% reduction among those with type 2 diabetes, with no signal of a significant difference among the three subgroups.

"There was no statistical interaction between categorical glycemic subgrouping and dapagliflozin's treatment effect," concluded Inzucchi, director of the Yale Medicine Diabetes Center, New Haven, Connecticut.

He also reported that among the 6259 people in the trial with HFpEF, 50% had diabetes, 31% had prediabetes, and a scant 19% had normoglycemia. The finding highlights once again the high prevalence of dysglycemia among people with HFpEF.

Previously, a prespecified secondary analysis of data from the EMPEROR-Preserved trial yielded similar findings for empagliflozin that showed the agent's efficacy for people with HFpEF across the range of glucose levels.

The DELIVER trial was funded by AstraZeneca, the company that markets dapagliflozin (Farxiga). The EMPEROR-Preserved trial was sponsored by Boehringer Ingelheim and Eli Lilly, the companies that jointly market empagliflozin (Jardiance). Lund has been a consultant to AstraZeneca and Boehringer Ingelheim and to numerous other companies, and he is a stockholder in AnaCardio. Sattar has been a consultant to and has received research support from AstraZeneca and Boehringer Ingelheim, and he has been a consultant to Eli Lilly, Afimmune, Amgen, Hammi, Merck Sharpe & Dohme, Novartis, Novo Nordisk, Pfizer, Roche, and Sanofi-Aventis. Kosiborod has been a consultant to and has received research funding from AstraZeneca and Boehringer Ingelheim and has been a consultant to Eli Lilly and numerous other companies. Inzucchi has been a consultant to and has given talks on behalf of AstraZeneca and Boehringer Ingelheim. He has also been a consultant to or has served on trial committees for Abbott, Esperion, Lexicon, Merck, Novo Nordisk, Pfizer, and vTv Therapetics.

European Association for the Study of Diabetes (EASD) 2022 Annual Meeting:Presented September 22, 2022.

Mitchel L. Zoler is a reporter with Medscape and MDedge based in the Philadelphia area. @mitchelzoler

For more diabetes and endocrinology news, follow us on Twitter and Facebook.

You can also follow Medscape on Instagram, YouTube and Linkedin.

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Diabetes: TXNIP involved in increased secretion of glucagon from pancreatic alpha cells – University of Alabama at Birmingham

Posted: October 4, 2022 at 2:21 am

Knockout of TXNIP improves diabetes-associated hyperglycemia and hyperglucagonemia.

Anath Shalev, M.D.In groundbreaking diabetes research over the past two decades, Anath Shalev, M.D., has shown that the protein TXNIP regulates survival and function of beta cells, the pancreatic cells that produce the hormone insulin to lower levels of glucose in the blood. Downregulation or inhibition of TXNIP in beta cells protects against diabetes in mouse models, and a repurposed clinical drug that inhibits TXNIP shows promising results in people with recent-onset Type 1 diabetes.

Beta cells play a key role in the pathogenesis of both Type 1 and Type 2 diabetes. However, pancreatic islets also have alpha cells that produce the hormone glucagon, which acts to raise glucose blood levels. Together, insulin and glucagon keep blood glucose levels stable.

To further understand the role of TXNIP in pancreatic islet biology and glucose control, Shalev and colleagues at the University of Alabama at Birmingham now report the effect of knocking out TXNIP in alpha cells.

While not as dramatic as beta-cell TXNIP knockouts, the alpha-cell knockout improved diabetes-associated hyperglycemia and hyperglucagonemia in a mouse model of streptozotocin-induced diabetes. Hyperglycemia and hyperglucagonemia excess levels of glucose and glucagon in the blood are hallmarks of diabetes.

The alpha-cell knockouts, known as aTKO mice, had normal glucose homeostasis and no gross abnormalities when fed on regular chow food. However, when the aTKO mice were fed a high-fat diet for 30 weeks to create glucose intolerance, they had a reduced high-fat diet-induced glucose intolerance compared to control mice on the high-fat diet. Glucose intolerance is an impaired ability to respond to a surge of dietary glucose.

In the knockout mice, there was no change in the architecture of the aTKO islets and the alpha cell numbers were unchanged. Furthermore, the expression levels of the glucagon gene and key islet transcription factors showed no change. However, glucagon secretion was decreased more than twofold in the aTKO islets compared to controls.

Out of five proteins recently reported to be involved in alpha cell glucagon expression, only one, Grp78, had significantly changed expression in the aTKO islets. This protein was recently confirmed to interact with glucagon in secretory granules, and it acts as a molecular chaperone in the cells endoplasmic reticulum, the transportation system of the cell where proteins are produced.

Thus, it appears that downregulation of alpha cell TXNIP can inhibit alpha cell glucagon secretion, which in turn may help explain the improvement in hyperglucagonemia and hyperglycemia observed in diabetic aTKO mice.

Interestingly, we recently found that pharmacological inhibition of TXNIP with a small molecule inhibitor also resulted in decreased alpha cell glucagon secretion in vitro in alphaTC1-6 cells and in vivo in different diabetes mouse models, said Shalev, director of the UAB Comprehensive Diabetes Center and professor in the Department of Medicine Division of Endocrinology, Diabetes and Metabolism. These findings strongly support our current results using genetic TXNIP deletion and together suggest that alterations in TXNIP regulate alpha cell glucagon secretion.

Co-authors with Shalev on the paper, Alpha cell TXNIP deletion improves diabetes-associated hyperglycemia and hyperglucagonemia, published in the journal Endocrinology, are Brian Lu, Junqin Chen, Guanlan Xu, Truman B. Grayson, Gu Jing and SeongHo Jo, all members of the UAB Comprehensive Diabetes Center and the UAB Department of Medicine, Division of Endocrinology, Diabetes and Metabolism.

Support came from National Institutes of Health grants DK078752 and Human Islet Research Network DK120379.

At UAB, Shalev holds the Nancy R. and Eugene C. Gwaltney Family Endowed Chair in Juvenile Diabetes Research. Medicine is a department in the Marnix E. Heersink School of Medicine.

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Insights on the Next Generation Diabetes Therapy and Drug Delivery Global Market to 2030 – Rising Incidences of Diabetes Globally and Increase in the…

Posted: October 4, 2022 at 2:21 am

DUBLIN, Sept. 30, 2022 /PRNewswire/ -- The "Next Generation Diabetes Therapy and Drug Delivery Market By Product, By Demographic, By Indication, By End User: Global Opportunity Analysis and Industry Forecast, 2020-2030" report has been added to ResearchAndMarkets.com's offering.

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The global next generation diabetes therapy and drug delivery market was valued at $7,080.6 million in 2020 and is projected to reach $28,044.23 million by 2030, registering a CAGR of 14.28% from 2021 to 2030.

The next generation diabetes therapy and the drug delivery devices are the advanced form of diabetic products that improve the quality of life of diabetic patients. These products help in the management of the blood glucose level of diabetic patient in minimally invasive manner. Oral and inhalable insulin introduce a different mode of insulin delivery in diabetic patients. It is a painless mode of introducing insulin than the injectable insulins, reducing the risk of skin irritation caused due to needles.

In addition, the dose volume is easily calculated in oral & inhalable insulin and helps to maintain the dosage time. Advanced diabetic therapy in the form of insulin patches, continuous glucose monitoring systems (CGMS), and artificial pancreas helps to improve management of blood sugar level and reduces the risk of any diabetic-related complications.

The main factors that drive the growth of the next generation diabetes therapy and the drug delivery market include, the benefits of using these advanced devices over conventional products and rise in the healthcare expenditure.

In addition, rise in incidences of diabetes globally and increase in the disposable income among the diabetic patients, further supplement the global next generation diabetes therapy and drug delivery market growth.

Conversely lack of awareness, cost restrains in the developing regions, and less variability in products are expected to obstruct the growth of the market during forecast years. On the other hand, development of affordable products with fewer side effects and presence of undiagnosed diabetic patients globally are expected to offer profitable opportunities for the growth of the market during the forecast period.

The global next generation diabetes therapy and drug delivery market is segmented based on product, demographic, indication, end user, and region. On the basis of product, it is classified into inhalable insulin, oral insulin, insulin patches, CGM systems, and artificial pancreas. On the basis of demographics, it is bifurcated into adult population (>14 years) and child population (?14 years). By indication, it is divided into type 1 diabetes and type 2 diabetes. On the basis of end users, it is categorized into diagnostics/clinics, ICUs, and home healthcare. Region-wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA.

The key market players profiled in the report include Abbott Laboratories, Medtronic, Inc., Sanofi S.A., Novo Nordisk, MannKind Corporation, Eli Lilly and Company, Dexcom, Inc., Senseonics Holding, Inc., Glysens Incorporated, and Johnson & Johnson.

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Key Benefits For Stakeholders

This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the next generation diabetes therapy and drug delivery market analysis from 2020 to 2030 to identify the prevailing next generation diabetes therapy and drug delivery market opportunities.

The market research is offered along with information related to key drivers, restraints, and opportunities.

Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.

In-depth analysis of the next generation diabetes therapy and drug delivery market segmentation assists to determine the prevailing market opportunities.

Major countries in each region are mapped according to their revenue contribution to the global market.

Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.

The report includes the analysis of the regional as well as global next generation diabetes therapy and drug delivery market trends, key players, market segments, application areas, and market growth strategies.

Key Topics Covered:

CHAPTER 1: INTRODUCTION

CHAPTER 2: EXECUTIVE SUMMARY

CHAPTER 3: MARKET OVERVIEW3.1. Market definition and scope3.2. Key findings3.2.1. Top investment pockets3.3. Porter's five forces analysis3.4. Top player positioning3.5. Market dynamics3.5.1. Drivers3.5.2. Restraints3.5.3. Opportunities3.6. COVID-19 Impact Analysis on the market

CHAPTER 4: NEXT GENERATION DIABETES THERAPY AND DRUG DELIVERY MARKET, BY PRODUCT4.1 Overview4.1.1 Market size and forecast4.2 Inhalable Insulin4.2.1 Key market trends, growth factors and opportunities4.2.2 Market size and forecast, by region4.2.3 Market analysis by country4.3 Oral Insulin4.3.1 Key market trends, growth factors and opportunities4.3.2 Market size and forecast, by region4.3.3 Market analysis by country4.4 Insulin Patches4.4.1 Key market trends, growth factors and opportunities4.4.2 Market size and forecast, by region4.4.3 Market analysis by country4.5 CGM Systems4.5.1 Key market trends, growth factors and opportunities4.5.2 Market size and forecast, by region4.5.3 Market analysis by country4.6 Artificial Pancreas4.6.1 Key market trends, growth factors and opportunities4.6.2 Market size and forecast, by region4.6.3 Market analysis by country

CHAPTER 5: NEXT GENERATION DIABETES THERAPY AND DRUG DELIVERY MARKET, BY DEMOGRAPHIC5.1 Overview5.1.1 Market size and forecast5.2 Adult Population (>14years)5.2.1 Key market trends, growth factors and opportunities5.2.2 Market size and forecast, by region5.2.3 Market analysis by country5.3 Child Population (14years)5.3.1 Key market trends, growth factors and opportunities5.3.2 Market size and forecast, by region5.3.3 Market analysis by country

CHAPTER 6: NEXT GENERATION DIABETES THERAPY AND DRUG DELIVERY MARKET, BY INDICATION6.1 Overview6.1.1 Market size and forecast6.2 Type 1 Diabetes6.2.1 Key market trends, growth factors and opportunities6.2.2 Market size and forecast, by region6.2.3 Market analysis by country6.3 Type 2 Diabetes6.3.1 Key market trends, growth factors and opportunities6.3.2 Market size and forecast, by region6.3.3 Market analysis by country

CHAPTER 7: NEXT GENERATION DIABETES THERAPY AND DRUG DELIVERY MARKET, BY END USER7.1 Overview7.1.1 Market size and forecast7.2 Diagnostic/Clinics7.2.1 Key market trends, growth factors and opportunities7.2.2 Market size and forecast, by region7.2.3 Market analysis by country7.3 ICUs7.3.1 Key market trends, growth factors and opportunities7.3.2 Market size and forecast, by region7.3.3 Market analysis by country7.4 Home Healthcare7.4.1 Key market trends, growth factors and opportunities7.4.2 Market size and forecast, by region7.4.3 Market analysis by country

CHAPTER 8: NEXT GENERATION DIABETES THERAPY AND DRUG DELIVERY MARKET, BY REGION

CHAPTER 9: COMPANY LANDSCAPE9.1. Introduction9.2. Top winning strategies9.3. Product Mapping of Top 10 Player9.4. Competitive Dashboard9.5. Competitive Heatmap9.6. Key developments

CHAPTER 10: COMPANY PROFILES10.1 Abbott laboratories10.1.1 Company overview10.1.2 Company snapshot10.1.3 Operating business segments10.1.4 Product portfolio10.1.5 Business performance10.1.6 Key strategic moves and developments10.2 Dexcom, Inc10.2.1 Company overview10.2.2 Company snapshot10.2.3 Operating business segments10.2.4 Product portfolio10.2.5 Business performance10.2.6 Key strategic moves and developments10.3 Eli Lilly and Company10.3.1 Company overview10.3.2 Company snapshot10.3.3 Operating business segments10.3.4 Product portfolio10.3.5 Business performance10.3.6 Key strategic moves and developments10.4 Glysens Incorporated10.4.1 Company overview10.4.2 Company snapshot10.4.3 Operating business segments10.4.4 Product portfolio10.4.5 Business performance10.4.6 Key strategic moves and developments10.5 Johnson & Johnson10.5.1 Company overview10.5.2 Company snapshot10.5.3 Operating business segments10.5.4 Product portfolio10.5.5 Business performance10.5.6 Key strategic moves and developments10.6 MannKind Corporation10.6.1 Company overview10.6.2 Company snapshot10.6.3 Operating business segments10.6.4 Product portfolio10.6.5 Business performance10.6.6 Key strategic moves and developments10.7 Medtronic plc10.7.1 Company overview10.7.2 Company snapshot10.7.3 Operating business segments10.7.4 Product portfolio10.7.5 Business performance10.7.6 Key strategic moves and developments10.8 Novo Nordisk A/S10.8.1 Company overview10.8.2 Company snapshot10.8.3 Operating business segments10.8.4 Product portfolio10.8.5 Business performance10.8.6 Key strategic moves and developments10.9 Sanofi S.A.10.9.1 Company overview10.9.2 Company snapshot10.9.3 Operating business segments10.9.4 Product portfolio10.9.5 Business performance10.9.6 Key strategic moves and developments10.10 Senseonics Holdings, Inc.10.10.1 Company overview10.10.2 Company snapshot10.10.3 Operating business segments10.10.4 Product portfolio10.10.5 Business performance10.10.6 Key strategic moves and developments

For more information about this report visit https://www.researchandmarkets.com/r/1ixrhs

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Peanut Butter and Diabetes: Can They Work Together? – Taste of Home

Posted: October 4, 2022 at 2:21 am

A registered nurse explains how peanut butter and diabetes can coexist in a healthy meal plan. In fact, the salty snack may even help you control your blood sugar.

Rich and creamy with the right amount of salty sweetness, peanut butter is a staple for a reason. It adds a punch of protein to quick snacks and keeps you full until dinnertime.

Its also a high-calorie food, so it can be confusing for people with diabetes. Here are a few tips to keep in mind before scooping up a spoonful of healthy peanut butter.

Yes, in moderation. Natural peanut butter is considered safe for people with diabetes. Its best to avoid the low-fat varieties of peanut butter. They sound healthybut most brands simply add more sugar to make up for less fat. This can spike blood sugar levels and leads to more daily carbohydrates.

Studies have shown that when people with type 2 diabetes follow a low-carb diet, they can reap health benefits from adding peanuts to their diets. By replacing certain foods with peanuts or natural peanut butter, its possible to lose weight, improve blood sugar control and regulate the amount of fat in the blood (also known as blood lipid level).

Peanut butter also helps control blood sugar in those who dont have diabetes. In fact, eating peanut butter may even lower the risk of developing type 2 diabetes. Peanut butter is rich in unsaturated fats that help the body regulate insulin and blood sugar levels. Peanuts are also rich in magnesium. Research shows that diets rich in magnesium can be protective against diabetes.

Not a fan of peanut butter? You can reap many of the same benefits with almond butter.

Peanut butter can get a bad rap for being high in calories. A two-tablespoon serving of peanut butter contains about 188 calories, 7.7 grams of protein, 6.9 grams of carbohydrates and 2.4 grams of saturated fat. When enjoyed in moderation, peanut butter can be a healthy part of your diabetes-friendly meal plan.

No, natural peanut butter will not raise blood sugar. In fact, it could stabilize your numbers.

A 2018 study found that eating two tablespoons of peanut butter with white bread and apple juice led to a significantly lower blood glucose spike when compared with white bread and juice alone. The protein and healthy fats in peanut butter help our bodies avoid a blood sugar spike (and eventual crash).

Adding peanut butter to your breakfast routine may aid in blood sugar control throughout the day. A 2012 study found that when women with obesity ate peanuts or peanut butter in the morning, they were more likely to be able to manage their blood sugar levels throughout the day.

Peanut butter is a high-calorie food, so its important to enjoy in moderation. Try replacing some refined carbs or processed meats with peanut butter. This will help avoid adding too many calories to your healthy eating plan.

When choosing peanut butter at the store, opt for a natural variety with as few ingredients as possible. Avoid any brands that add sugar or other sweeteners. Ditch any low-fat varieties because they are typically loaded with sugar. Some brands use partially hydrogenated oils in their peanut butter. These oils have been linked to heart disease, so skip those as well.

To choose the best peanut butter for you and your health, start by reading the ingredient list. Crazy Richards 100% Peanuts Peanut Butter has one ingredient: peanuts! Learn more about how to shop for healthy peanut butter.

You can eat peanut butter with all kinds of healthy diabetes snacks. Here are a few of our favorite ideas:

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Prevalence of Microalbuminuria and Cardiovascular Risk Factors in Patients With Diabetes Mellitus Type-II in Al-Khobar, Kingdom of Saudi Arabia -…

Posted: October 4, 2022 at 2:21 am

Background

Type 2 diabetes mellitus (T2DM) is a common disorder worldwide. Impaired control of glucose levels predisposes to renal dysfunction, detected by a diagnosis of microalbuminuria. Several other risk factors have been identified in the development of microalbuminuria, such as hypertension, smoking, dyslipidemia, and obesity.

Assessment of microalbuminuria and cardiovascular risk factors in type-II diabetic patients who attended the outpatient clinic for the internal medicine department at King Fahd University Hospital, Al-Khobar.

A retrospective cross-sectional and an observational study included data from 2014 to 2022 collected from medical records. Patients with diabetes type-II and aged 18 years were included. The following were reviewed (age, sex, height, weight, body mass index, waist, hip, waist-hip ratio, systolic and diastolic blood pressure, smoking, sedentary lifestyle, diagnosis of dyslipidemia/hypertension, diabetes duration in years) and laboratory results (fasting blood glucose, HbA1C%, estimated glomerular filtration rate, serum creatinine, serum cholesterol, low-density lipoprotein, high-density lipoprotein, and triglycerides). Microalbuminuria was measured by the urine albumin to creatinine ratio and was diagnosed if levels were 30-300 mg/g.

Among 301 studied patients, the prevalence of microalbuminuria was found at 36.8%. The mean age was 57.8 12.6 years, and females were 45%. The mean SD fasting blood glucose was 165.9 71.9 mg/dL, while HbA1C% was 8.8 5.6. Microalbuminuria was significantly associated with age, diabetes duration, systolic blood pressure, HbA1C%, fasting blood glucose, and triglyceride levels (p0.05).

Microalbuminuria in T2DM patients was high in this study, which emphasizes the need for early detection of microalbuminuria. The study suggests the need for effective diabetes control and the prevention of associated cardiovascular risk factors.

Microalbuminuria is an early representative of renal damage or nephropathy in diabetic patients. Microalbuminuria is defined as the increase in urine albumin excretion (30-300 mg/day) or (20-200 mg/day). Urine albumin/creatinine ratio (urine ACR) is the preferred screening approach. Microalbuminuria is diagnosed when urine ACR levels range from 30 to 300 mg/g [1]. Diabetic nephropathyaffects around one-third ofpatients with type 2 diabetes mellitus (T2DM) in Saudi Arabia [2].It has the highest rate when compared to the global incidence of end-stage renal disease caused by diabetic nephropathy [3]. Hence, screening for microalbuminuria in diabetic patients can help in the early detection of diabetic nephropathy and the prevention of further complications.

Hypertension, smoking, hyperglycemia, dyslipidemia, and overweight or obesity are all cardiovascular risk factors that have been associated with the development ofmicroalbuminuria [4]. Glycation of the glomerular basement membrane can occur as a consequence of chronic hyperglycemia and inadequate glycemic management. This, in turn, leads to the progression of diabetic nephropathy as a result of a high glomerular filtration rate and low filtration capacity [5]. Hypertension has been associated with a higher risk of cardiovascular disease. As a result, it causes proteinuria and reduced renal function. Albumin exertion in the urine has been linked to hydrostatic pressure alterations in the afferent glomerulus, increased leakage of the glomerular basal membrane, and poor tubular function in hypertensive patients [6].

Recent studies have concluded that diabetic nephropathy progression is associated with dyslipidemia. High levels of blood total cholesterol (TC), low-density lipoprotein (LDL), serum triglycerides (TG), and low levels of high-density lipoprotein (HDL) characterize diabetic dyslipidemia [7]. Since albuminuria is substantially related to high levels of total cholesterol, the presence of dyslipidemia can be used as an assessment tool for microalbuminuria among patients with T2DM[8]. Cigarette smoking has an independent association with increasing levels of urine albumin. When compared to non-smokers, patients with T2DM who were current smokers had an increased incidence of microalbuminuria per year [9].

Body mass index (BMI) and waist-to-hip ratio (WHR) have been significantly associated with microalbuminuria[10]. The specific pathogenesis regarding obesity-related glomerulopathy is hyperfiltration, which is mediated by excessive protein and salt intake, high blood insulin levels, and increased feedback of the tubuloglomerular component. Central obesity is associated with the secretion of active proteins and proinflammatory cytokines, which play a role in renal injury [11]. Although the previously mentioned metabolic irregularities contribute to renal impairment, there is little evidence regarding the relationship between WHR and microalbuminuria in patients with T2DM as has been established in one study [12]. Hence, studying the association between central obesity and microalbuminuria is one of the main goals of our research. The current study aims to estimate microalbuminuria prevalence and assess the related cardiovascular risk factors among patients with T2DM in Al-Khobar, Saudi Arabia.

This study is a retrospective, cross-sectional study conducted on patients with T2DM who attended the department of internal medicine at King Fahd University Hospital (KFUH) Al-Khobar, Eastern Province, Saudi Arabia from January 2014 to December 2021. Ethical approval from the Imam Abdulrahman Bin Faisal University Institutional Review Board was obtained.

The study comprised 301 patients with T2DM. Inclusion criteria: patients diagnosed with T2DM, aged 18 years, both males and females were included. Exclusion criteria: patientsaged <18 years, previously diagnosed with diabetes type-I, congestive heart failure, chronic kidney disease, or nephrotic syndrome, any patient with a history of steroid use, exposure to radiocontrast agents, active urinary tract infection, fever or pregnancy at the time of urine ACR test was excluded from the study.

Demographic, anthropometric, clinical and laboratorical information for the included patients were reviewed and retrieved from the KFUH database, Quadra Med Computerized Patient Record (QCPR).Past medical history including the duration of diabetes and the diagnosis of hypertensionand dyslipidemia were taken from outpatient clinic visit notes. Age, gender, height, weight, and body mass index (BMI), which was calculated and classified into normal (<25), overweight (25-29.9), obese (30-39.9), and morbidly obese (>40), the circumference of waist and hip, waist-hip ratio, smoking status, sedentary lifestyle (inactive) [13]. The readings included were systolic blood pressure, diastolic blood pressure, and pulse pressure. HbA1C% and fasting blood glucose (FBG) were used for the assessment of glucose control. HbA1C% was classified as controlled (<7%) and uncontrolled (7%), while fasting blood glucose readings were divided into normal (<130 mg/dL) and abnormal ( 130 mg/dL) [14]. Patients lipid profiles for dyslipidemia assessment included total cholesterol, LDL, HDL, and triglycerides. Other important laboratory data for renal profile were serum creatinine and estimated glomerular filtration rate (eGFR), which were calculated by the Modification of Diet in Renal Disease (MDRD) study equation (175 standardized Scr 1.154 age0.203 1.212 (if black) 0.742 (if female)) [15]. eGFR results were classified by the National Kidney Foundation into the following (normal/high 90, mildly decreased 60-80, mildly-moderately decreased 45-59, moderately-severely decreased 30-44) [16]. Microalbuminuria was detected according to hospital policy by using a random spot urine sample. The urine albumin-creatinine ratio was calculated by dividing albumin concentration in milligrams by creatinine concentration in grams. A value of 30-300 mg/g was considered positive microalbuminuria [17]. Statistical analysis was performed by using SPSS Statistics for Windows, version 26.0 (IBM SPSS Statistics for Windows, IBM Corp, Armonk, NY).

Table 1shows the demographic features and associated variable characteristics of all 301 included patients. The mean age was 57.76 12.64 years. Males (55.1%) were slightly more than females in number. The majority of the patients never smoked, while (25.6%) were smokers. Most of the patients (64.1%) had dyslipidemia. About 57% had hypertension, which is less than expected. Sedentary lifestyle was noticed among more than half of the patients. Most of the participants had high BMI readings. The mean waist-hip ratio was 0.9, which is in the high-risk category for metabolic complications. As for the T2DM duration, most of the patients (64.1%) had been diagnosed with T2DM for more than five years. While diastolic and pulse pressure were in the normal range with values of 78.91 11.55 and 55.38 18.21, respectively. The mean systolic blood pressure was high at 136.2 19.43. For blood glucose control, the majority had uncontrolled diabetes (HbA1C of 7%) with a mean level of 8.82 5.58. While fasting blood glucose was abnormal at 66.1%, with a mean level of 165.9 71.94. The mean urine albumin, urine creatinine, and urine ACR were in accordance with microalbuminuria findings. While serum creatinine was within the normal range for most of the patients, about 43.5% had a mildly decreased (60-80) eGFR (mL/min/body surface area (BSA)) with a mean level of 81.11 25.33. More than half of the patients (64.1%) had high cholesterol, LDL, TG levels, and low HDL levels.

Table 2 shows a prevalence of 36.8% for microalbuminuria. Patients with older age, T2DM duration of more than 15 years, elevated systolic BP, high HbA1C (7%), abnormal FBG (130 mg/dL), and high TG levels were found to have a significantly higher percentage of microalbuminuria (p 0.05). Whereas the relationship between microalbuminuria and other patients socio-demographic or disease-related characteristics was found to be non-significant (p 0.05).

Table 3 represents the correlation of urine ACR levels and microalbuminuria with all the numerical variables. A correlation with age, T2DM duration, pulse pressure, FBG, HbA1C, and TG levels was found to be significantly positive (p 0.05).

Table 4 represents the correlation of FBG and HbA1C levels with all the numerical variables. A correlation with T2DM duration, hip-waist-ratio, urine creatinine, urine albumin, total cholesterol, and TG was found to be significantly positive (p 0.05).

Detection of microalbuminuria is one of the crucial steps in managing diabetic patients as it is considered an early sign of renal impairment and subsequent diabetic nephropathy [1]. In this study, 301 diabetic patients were investigated for microalbuminuria and its associated risk factors. The screening for microalbuminuria was conducted using a random sample of urine to test for urine ACR, which is the recommended screening method for microalbuminuria [1]. This studys microalbuminuria prevalence was 36.8%. Previous studies showed a similar result, which was reported in multiple cross-sectional studies in Saudi Arabia ranging from 33.2% to 41.3%, 31.8% to 34.2% in Egypt, and 39% in the DEMAND study globally [17-22].

Despite the similar microalbuminuria prevalence in the current study, there is a possibility of variation in prevalence based on a number of factors related to differences in the population characteristics, microalbuminuria definition, measurement methods, and collection of urine [17]. Gender-specific association with microalbuminuria has been reported in several studies. However, there were a few studies that reported no statistical significance between gender and microalbuminuria [19,22-24]. Our study shows a similar result, in which there was no statistical significance between gender and microalbuminuria. A male predominance in the prevalence of microalbuminuria was reported [8,25,26]. While many other studies reported that the female gender was associated with microalbuminuria [17,18,21,27].

Multiple cross-sectional studies found no association between age and microalbuminuria [17,19,23-26,28]. On the contrary, a few studies reported a statistical significance betweenage and microalbuminuria [8,21]. In the present study, age was observed to be significantly related to microalbuminuria. The present study showed a significant association of longer diabetes duration with the presence of microalbuminuria, which was similar to a previous study [18]. This could be justified by how theperpetuation of hyperglycemia would result in the build-up of glycosylation end products and the presence of protein in urine [5].

Chronic hyperglycemia leads to a decline in renal function by glycation of glomerular basement membranes and stiffening of efferent arterioles. This will adversely increase the glomerular filtration rate, regress filtration capacity and give rise to diabetic nephropathy [5]. HbA1C 7% is an indicator of poor glycemic control. The mean value of HbA1C% for the microalbuminuria group was (8.95 1.79) compared to (8.4 1.84) in patients with normal urine ACR. This study showed a significant association of uncontrolled HbA1C with microalbuminuria similar to a study done in Taif, Saudi Arabia [23]. The mean value of abnormal FBG 130 among patients with microalbuminuria was (176.5 71.87) while for non-microalbuminuria patients it was (159.99 81.63). A significant relationship was noticed among the microalbuminuria group as it was found in other studies [19,20]. Poor glycemic control is a widely known cause of diabetic nephropathy. Our findings were consistent with a previous study [25].

Hypertension is a recognized risk factor for renal impairment [6]. This study has shown a nonsignificant relationship between hypertension diagnosis and microalbuminuria. A similar finding was noted in Alzaid et al., where hypertension had no significance on microalbuminuria [19]. While the contrary was found in several studies [21,23,25,29]. On the other hand, high systolic blood pressure was found to be significantly associated with the presence of microalbuminuria in this study, as seen in a similar study [29]. Increased systolic blood pressure negatively impacts renal function by affecting the systemic arterioles and constant insult to the glomerular filtration membrane resulting in microalbuminuria [30].

Dyslipidemia is a well-studied risk factor for diabetic nephropathy [7]. Previous studies demonstrated a statistical significance regarding the high levels of LDL with the occurrence of microalbuminuria [17,27]. Showail et al. reported a statistical significance between the high levels of total cholesterol, triglycerides, and microalbuminuria [8]. Our study shows a similar result in which high levels of triglycerides were statistically significant with microalbuminuria. However, many studies showed non-statistical significance between lipid profile parameters and microalbuminuria [17,19,23,24,28].

Obesity-related glomerulopathy has been associated with hyperfiltration, which is mediated by excessive protein and salt intake, high blood insulin levels, and increased feedback on the tubuloglomerular component [11]. A few earlier studies demonstrated a statistical significance between BMI and microalbuminuria [17,21,28,26]. Many studies, on the contrary, have not reported statistical significance. This finding was seen in the DEMAND study globally, which was possibly supported by the fact that the Asian population had the lowest BMI despite the highest rates of microalbuminuria [22]. Other studies done in the Middle East showed a similar result of non-significance [8,18,19,23-26]. In the present study, BMI and microalbuminuria did not have a statistically significant relationship.

Central obesity, measured by waist-to-hip ratio, is associated with the secretion of active proteins and proinflammatory cytokines that have a role in renal injury [11]. Based on the literature review, only one study showed a statistical significance between high WHR and microalbuminuria in females with T2DM[12]. Most of the participants in the study were in the higher risk group for WHR. Our study failed to show an association of WHR with microalbuminuria.

Tobacco smoking is one of the independent risk factors for increasing levels of urine albumin [9]. Our study has shown a non-significant relationship with microalbuminuria as seen in other studies [22,24]. On the contrary, many studies reported tobacco use as a risk factor and had linked smoking to the development of microalbuminuria [21,22,25]. Our controversial findings could be attributed to the small sample size and low prevalence of female smokers.

Despite thegood preparation of this study, there were a few limitations. The study participants were from a single hospital in the Al-Khobar area. Due to time restrictions, the sample size was very small to represent the prevalent number of diabetic patients in society. Furthermore, the data collection was clinic-based, so the result was exclusively observed for patients who were following up on a regular basis.

Microalbuminuria is one of the important tests for early renal damage in T2DMpatients. A prolonged duration of diabetes, an increase in age, poor diabetes control, an increased level of triglycerides, and high systolic blood pressure were associated with microalbuminuria. Thus, annual screening for microalbuminuria, maintaining good glycemic control, and managing cardiovascular risk factors can help in reducing microalbuminuria and the progression into diabetic nephropathy. This study encourages regular and early screening of microalbuminuria and the prevention of irreversible kidney damage that results from poor diabetic control. Moreover, the renal injury could be exacerbated by other cardiovascular risk factors such as dyslipidemia and hypertension. This study implements educational material to enhance patient awareness and understanding of their condition and how crucial diabetic control is for reducing complications.

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Nancy and Geoffrey Stack Family Foundation give $2 million to UCI Health – UCI News

Posted: October 4, 2022 at 2:20 am

Oct. 3, 2022, Irvine, Calif. UCI Health is pleased to announce a $2 million gift that will benefit the emergency department in the new $1.3 billion UCI Health Irvine medical campus being built on the corner of Jamboree Road and Birch Street in Irvine.

The gift, funded by the Nancy and Geoffrey Stack Family Foundation, will name the patient welcome areas in the emergency department of the planned acute care hospital and at the Chao Family Comprehensive Cancer Care and Ambulatory Care building.

UCI Health is grateful for the friendship and generosity of Nancy and Geoffrey Stack, said UCI Health CEO Chad Lefteris. With their support, we continue to improve access to the clinical innovation, lifesaving research, and world class care of Orange Countys only academic health system.

In November, UCI and the universitys health enterprise, UCI Health, officially broke ground on the medical complex, which will include a 144-bed general acute care hospital with an emergency department, the Chao Family Comprehensive Cancer Center and Ambulatory Care center and the Joe C. Wen & Family Center for Advanced Care.

The UCI Health Irvine complex will support the systems growing primary and specialty care network in coastal and south Orange County, Lefteris said.

UCI Health is a beacon of hope in Orange County, said Nancy Stack. The new medical complex will bring hope and healing to our region and will save lives. Jeff and I are honored to support such a worthwhile cause.

The Stacks are longtime supporters of UCI Health. The couple has made previous philanthropic gifts to support UCI Medical Center in Orange. They have continued their legacy of giving by investing in healthcare through the UCI Health Irvine medical campus.

The new UCI Health Irvine medical campus will complement the UCI Medical Center in Orange and will be a key part to providing the region with the advanced care available only from a health system that is part of a leading, premier academic research institution. The hospital will include a 24-hour emergency department and focus on leading clinical programs including oncology, neurology, neurosurgery, orthopedics, and digestive health. The first patients are expected in 2023 at the Joe. C. Wen & Family Center for Advanced Care. The Chao Family Comprehensive Cancer Care and Ambulatory Care building, and the hospital will begin serving patients in 2023 and 2025, respectively.

Nancy and Geoffrey Stack Family Foundation was created by the longtime Orange County residents to support education, health and other vital community-based programs in Orange County and beyond. Geoffrey Stack is one of the founding partners of the Sares-Regis Group, a commercial and residential real estate development and management firm. Nancy Stack is founder and president of the Cystinosis Research Foundation, which supports medical research including stem cell research seeking a cure for the rare disease cystinosis.

If you want to learn more about supporting this or other activities at UCI, please visit the Brilliant Future website athttps://brilliantfuture.uci.edu. Publicly launched on Oct. 4, 2019, the Brilliant Future campaign aims to raise awareness and support for UCI. By engaging 75,000 alumni and garnering $2 billion in philanthropic investment, UCI seeks to reach new heights of excellence instudent success,health and wellness, research and more. UCI Health plays a vital role in the success of the campaign. Learn more by visiting https://brilliantfuture.uci.edu/uci-health/

About UCI Health:UCI Healthis the clinical enterprise of the University of California, Irvine. Patients can access UCI Health at primary and specialty care offices across Orange County and at its main campus,UCI Medical Center in Orange, Calif. The 459-bed acute-care hospital, listed among Americas Best Hospitals byU.S. News & World Reportfor 22 consecutive years, provides tertiary and quaternary care, ambulatory and specialty medical clinics, as well as behavioral health and rehabilitation services. UCI Medical Center is home to Orange Countys onlyNational Cancer Institute-designated comprehensive cancer center,high-risk perinatal/neonatal programandAmerican College of Surgeons-verified Level I adult and Level II pediatric trauma centerandregional burn center. It is the primary teaching hospital for theUCI School of Medicine. UCI Health serves a region of nearly 4 million people in Orange County, western Riverside County and southeast Los Angeles County. Follow us onFacebookandTwitter.

About the University of California, Irvine:Founded in 1965, UCI is the youngest member of the prestigious Association of American Universities and is ranked among the nations top 10 public universities byU.S. News & World Report. The campus has produced three Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 36,000 students and offers 224 degree programs. Its located in one of the worlds safest and most economically vibrant communities and is Orange Countys second-largest employer, contributing $7 billion annually to the local economy and $8 billion statewide. For more on UCI, visitwww.uci.edu.

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Bidens transhumanist EO calls for natural biology to be programmed …

Posted: October 4, 2022 at 2:19 am

by Ramon Tomey, Natural News:

An executive order (EO) by President Joe Biden calledfor natural biologyto be programmed like computers a clear push for transhumanism under the guise of public health.

On Sept. 12,Biden signed EO 14081that sought to bolster the U.S. biotechnology industry. It proposed the use of biotechnology to aid human health, citing the role of such biotechnologies during the Wuhan coronavirus (COVID-19) pandemic.

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The COVID-19 pandemic has demonstrated the vital role of biotechnology and biomanufacturing in developing and producing life-saving diagnostics, therapeutics and vaccines that protect Americans and the world, the EO stated. The power of these technologies is most vivid at the moment in the context of human health.

Given this, EO 14081 called on the secretary of health and human services to submit a report assessing how to use biotechnology to achieve medical breakthroughs, reduce the overall burden of disease, and improve health outcomes. According to the edict, the report shall identify high-priority basic research and technology development needs [alongside] recommendations for actions to enhance biosafety and biosecurity to reduce risk throughout the biotechnology R&D and biomanufacturing lifecycles.

The EO also mandated the establishment of a Data for the Bioeconomy Initiative, which requires biological data sets including gene-related information deemed critical for social advances. In line with this, it called for a plan to fill any data gaps and to make new and existing public data findable and accessible.

EO 14081 tried to allay the fears of critics by implementing adata-protection plan to mitigatesecurity and privacy risks. However, the initiative raises the question of whether and how individuals genomic information might be publicly disclosed, and whether it would be done so only with informed consent.

Bidens call for the programming of biology the way we program software, if applied to humans, would facilitate [the] transhumanist vision of the creation of superhumans through various kinds of technology, including biotechnology, wroteEmily Mangiaracina forLifeSiteNews.

Bidens transhumanist EO 14081 oddly echoed the concept of hackable humans promoted by Israeli intellectual Yuval Noah Harari.

Today, we have the technology to hack human beings on a massive scale, said Harari, a lead advisor for the World Economic Forum (WEF).Everything is being digitalized [and] monitored.

According to Harari, the pandemic serves asa chance to bring hackable humans closer to reality thanks to the COVID-19 vaccines, which he branded as tools to facilitate surveillanceunder the skin.

The vaccine will help us, of course. It will make things more manageable, [such as] surveillance. People could look back in a hundred years and identify the [COVID-19] pandemic as the moment when a regime of surveillance took over especially surveillance under the skin, he said.(Related:Yuval Noah Harari: Humans are now HACKABLE ANIMALS thanks to vaccines.)

This ability to hack human beings, to go under the skin, collect biometric data, analyze it and understand people better than they understand themselves is the most important event of the 21st century.

During a separate lecture, the WEF advisor explained how this ability to hack humans can be achieved.

Biological knowledge, multiplied by computing power, multiplied by data equals the ability to hack humans.If you know enough biology and you have enough computing power and data you can hack my body, my brain and my life, he said.

In the past, many tyrants and governments wanted to do it. But nobody understood biology well enough, and nobody had enough computing power and data to hack millions of people. Neither the Gestapo nor the KGB could do it. But soon, at least some corporations and governments will be able tosystematically hack all the people.

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