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Seven days: 39 October 2014

Posted: October 9, 2014 at 3:49 am

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Nobel prizes Three neuroscientists share this years Nobel Prize in Physiology or Medicine for their insights into the neural basis of spatial navigation. John OKeefe was honoured for his discovery of place cells, which are activated when a rat passes particular spots; May-Britt Moser and Edvard Moser discovered grid cells, which help to create a coordinate system in the brain. The physics prize was awarded to Isamu Akasaki, Hiroshi Amano and Shuji Nakamura for their invention of blue light-emitting diodes (LEDs), which enabled todays bright, energy-efficient white LEDs. See pages 152, 153 and 154 for more. Nature went to press before the chemistry prize was awarded, but full details will be available at go.nature.com/ygtzbs.

Corey Accardo/NOAA

Walruses seek shelter on land A lack of sea ice has driven more than 35,000Pacific walruses (Odobenus rosmarus divergens) onto land at Point Lay, Alaska, the US Geological Survey said on 1 October. The animals normally spend summers resting on ice floes, occasionally diving to the ocean floor to feed on clams, snails and worms. But with ice levels low in the Chukchi Sea this summer, walruses have come ashore in record numbers (pictured). The animals are easily spooked, so scientists say that the risk of fatal stampedes is high. The US Fish and Wildlife Service is considering whether to protect the Pacific walrus under the Endangered Species Act owing to harm from hunting and sea-ice loss; a decision is expected in 2017. See page 140 for more.

Ebola exported A health worker in Spain has tested positive for Ebola, the countrys health minister said on 6 October. The worker, the first person thought to have contracted the virus outside Africa, had treated a missionary who had returned to Spain from Sierra Leone. On 30 September, health officials confirmed the first case of Ebola diagnosed in the United States a man who arrived in Dallas, Texas, from Liberia on 20 September. On 6October, the US Centers for Disease Control and Prevention said that the man may have exposed up to 48people to the virus. See page139 for more.

Animal care A UK government report released on 2October cleared Imperial College London of nearly all allegations of animal cruelty raised by an animal-rights group in 2013. But the Home Office investigation noted persistent shortcomings in the management of animal care, and five instances of non-compliance since addressed by the university that were symptomatic of a widespread poor culture of care in the universitys animal-research laboratories. See go.nature.com/wyc2vz for more.

Telescope turns on A 12-metre radio telescope on Kitt Peak in Arizona has begun observations, scientists at the University of Arizona in Tucson said on 2 October. The telescope is one of three prototypes originally made for the Atacama Large Millimeter/submillimeter Array (ALMA) in Chile, and will be used to study phenomena such as molecules in interstellar space and supermassive black holes. The university lost a bid for another of the prototype dishes in 2011; that antenna is destined for Greenland (seepage 147).

Stem-cell saga ends Italys health ministry will not support a trial of a controversial stem-cell therapy that it had promised last yearmarking the end of a two-year battle between the therapys inventor and Italian scientists who had declared the treatment ineffective and possibly dangerous. Health minister Beatrice Lorenzin announced her final decision on 2October, on the basis of conclusions from an expert committee that was convened after a court ruled a previous committee had been illegally biased. See go.nature.com/zlryhz for more.

PNAS rules tighten The Proceedings of the National Academy of Sciences (PNAS) closed one of its avenues to publication on 1October. Editor-in-chief Inder Verma said that the journal will discontinue its pre-arranged editor process, whereby authors could submit manuscripts through a member of the academy. See go.nature.com/szpjio for more.

USIndia space pact The US and Indian space agencies signed an agreement on 30September to increase their collaborative efforts. A working group will coordinate observations between NASAs MAVEN mission and the Mars Orbiter Mission of the Indian Space Research Organisation which arrived at Mars on 21and 24September, respectively and explore cooperative efforts on future Mars missions. They will also jointly launch an Earth-observing satellite in 2020.

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Hamish Gilbert – Development of a Stem Cell Therapy forRepair of the Degenerate Intervertebral Disc – Video

Posted: October 9, 2014 at 3:41 am


Hamish Gilbert - Development of a Stem Cell Therapy forRepair of the Degenerate Intervertebral Disc
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Ageless Derma Anti Aging Skin Care – Video

Posted: October 8, 2014 at 9:52 pm


Ageless Derma Anti Aging Skin Care
This active ingredient won the Best Active Ingredient prize in European Innovation in 2008. Stem Cells derived from a rare Swiss Apple are part of the revolutionary technological designed...

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Stem cell treatments surging into the clinic

Posted: October 8, 2014 at 9:45 am

Michael Scott, a ViaCyte vice president, holds the VC-01 device that holds progenitor cells that will mature to make insulin and other hormones.

More than ever before, stem cell therapies appear poised to transform medicine potentially curing heart disease, diabetes and paralyzing injuries, among other ailments.

But its also clear that such innovations will be very expensive.

How the government, insurers and patients will pay for what could be a flood of these new treatments drew the attention of more than 700 biomedical and health-care executives Tuesday at the 2014 Stem Cell Meeting on the Mesa.

The annual conference, held on La Jolla's Torrey Pines Mesa, will run through Thursday. It brings together the business and academic worlds of cell therapy, including but not limited to stem cell treatments.

In California alone, 131 clinical trials are taking place with stem cells, according to Clinicaltrials.gov, a government website that tracks clinical trials. Patients are being treated for conditions such as blindness from retinal diseases, HIV, leukemia, sickle cell disease, stroke and aging of skin.

The recent proliferation of clinical trials marks great progress toward the ultimate goal of getting new treatments to patients, said stem cell researcher Jeanne Loring, who directs the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla.

Its been a sea change from last year, said Loring, who is working with some colleagues in planning their own stem cell trial to treat Parkinsons disease.

Theyre developing replacement neurons grown from artificial embryonic stem cells called induced pluripotent stem cells. The process begins with cells derived from the skin of patients to be treated.

Home-grown milestone

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5-D stem cell movie: neural stem cells in their vascular niche – Video

Posted: October 8, 2014 at 8:45 am


5-D stem cell movie: neural stem cells in their vascular niche
This movie is a 5-D image sequence. The first three dimensions are (x,y,z). Time is dimension number four. The fifth dimension is the microscope imaging ch...

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Characteristics of stem cells / part 4 (. ) – Video

Posted: October 8, 2014 at 8:45 am


Characteristics of stem cells / part 4 (. )

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Reconstruction of Phrenic Identity in Embryonic Stem Cell-Derived Motor Neurons in Rap – Video

Posted: October 8, 2014 at 8:45 am


Reconstruction of Phrenic Identity in Embryonic Stem Cell-Derived Motor Neurons in Rap
Science paper by Dr. Carolina Barcellos Machado et al., published in Development journal: http://dev.biologists.org/content/141/4/784.abstract. Rap written and performed by Phil Day, author...

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Stem cells and nanofibers – Video

Posted: October 8, 2014 at 8:45 am


Stem cells and nanofibers
Nanofiber tendons in a 3 year old frisian mare.

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Obama Cloning Connection to Ancient Egypt? – Video

Posted: October 8, 2014 at 8:45 am


Obama Cloning Connection to Ancient Egypt?
President Obama and theories of cloning and stem cell research linking him to ancient Egypt are explored. Is Obama a clone of Akhenaten? Freeman Fly looks at Michelle Obama, Queen Tiye, secret...

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How did the Berlin patient become cured of HIV?

Posted: October 7, 2014 at 8:53 pm

By Jon Cohen October 6

Researchers are closer to unraveling the mystery of how Timothy Ray Brown, the only human cured of HIV, defeated the virus, according to a new study. Although the work doesnt provide a definitive answer, it rules out one possible explanation.

Brown remains one of the most studied cases in the HIV epidemics history. In 2006, after living with the virus for 11 years and controlling his infection with antiretroviral drugs, he learned that he had developed acute myeloid leukemia. (The leukemia has no known relationship to HIV infection or treatment.) Chemotherapy failed, and the next year Brown received the first of two bone marrow transplants a common treatment for this cancer and ditched his antiretrovirals. (An American then living in Berlin, Brown has been known to researchers for years as the Berlin patient.

When HIV-infected people stop taking these drugs, levels of HIV typically skyrocket within weeks. Yet researchers scouring Browns blood over the past seven years have found only traces of the viral genetic material, none of which can replicate.

Today, researchers point to three factors that might independently or in combination have ridden Browns body of HIV. The first is the process of conditioning, in which doctors destroyed Browns immune system with chemotherapy and whole-body irradiation to prepare him for his bone marrow transplant.

Second, his oncologist, Gero Htter, took an extra step that he thought might not only cure the leukemia but also help rid Browns body of HIV. He found a bone marrow donor who had a rare mutation in a gene that cripples a key receptor on white blood cells that the virus uses to establish an infection.

The third possible explanation is that Browns new immune system attacked remnants of his old one that held HIV-infected cells, a process known as graft vs. host disease.

In the new study, a team led by immunologist Guido Silvestri of Emory University in Atlanta designed an unusual monkey experiment to test these possibilities.

Bone marrow transplants work because of stem cells. Modern techniques avoid actually aspirating bone marrow and instead can sift through blood and pluck out the stem cells needed for a transplant to engraft. So the researchers first drew blood from three rhesus macaque monkeys, removed stem cells and put the cells in storage. They then infected these animals and three control monkeys with a hybrid virus, known as SHIV, that contains parts of the simian and human AIDS viruses. All six animals soon began receiving antiretroviral drugs, and SHIV levels in the blood quickly dropped below the level of detection on standard tests, as expected.

A few months later, the three monkeys with stored stem cells underwent whole-body irradiation to condition their bodies and then had their own stem cells reinfused. After the cells engrafted, a process that took a few more months, the researchers stopped antiretrovirals in the three animals and in the three controls. SHIV quickly came screaming back in the three controls and two of the transplanted animals. (One of the transplanted monkeys did not have the virus rebound, but its kidneys failed and the researchers euthanized it.)

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